-- dump date   	20140619_153254
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
164756000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
164756000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756000003	Walker A motif; other site
164756000004	ATP binding site [chemical binding]; other site
164756000005	Walker B motif; other site
164756000006	arginine finger; other site
164756000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
164756000008	DnaA box-binding interface [nucleotide binding]; other site
164756000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
164756000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
164756000011	putative DNA binding surface [nucleotide binding]; other site
164756000012	dimer interface [polypeptide binding]; other site
164756000013	beta-clamp/clamp loader binding surface; other site
164756000014	beta-clamp/translesion DNA polymerase binding surface; other site
164756000015	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756000016	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
164756000017	recombination protein F; Reviewed; Region: recF; PRK00064
164756000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
164756000019	Walker A/P-loop; other site
164756000020	ATP binding site [chemical binding]; other site
164756000021	Q-loop/lid; other site
164756000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756000023	ABC transporter signature motif; other site
164756000024	Walker B; other site
164756000025	D-loop; other site
164756000026	H-loop/switch region; other site
164756000027	hypothetical protein; Provisional; Region: PRK03195
164756000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
164756000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756000030	Mg2+ binding site [ion binding]; other site
164756000031	G-X-G motif; other site
164756000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
164756000033	anchoring element; other site
164756000034	dimer interface [polypeptide binding]; other site
164756000035	ATP binding site [chemical binding]; other site
164756000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
164756000037	active site
164756000038	putative metal-binding site [ion binding]; other site
164756000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
164756000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
164756000041	CAP-like domain; other site
164756000042	active site
164756000043	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
164756000044	protein-splicing catalytic site; other site
164756000045	thioester formation/cholesterol transfer; other site
164756000046	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
164756000047	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
164756000048	DNA gyrase subunit A; Validated; Region: PRK05560
164756000049	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
164756000050	primary dimer interface [polypeptide binding]; other site
164756000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
164756000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
164756000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
164756000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
164756000055	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
164756000056	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
164756000057	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
164756000058	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
164756000059	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
164756000060	active site
164756000061	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
164756000062	putative septation inhibitor protein; Reviewed; Region: PRK00159
164756000063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
164756000064	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
164756000065	Glutamine amidotransferase class-I; Region: GATase; pfam00117
164756000066	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
164756000067	glutamine binding [chemical binding]; other site
164756000068	catalytic triad [active]
164756000069	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
164756000070	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756000071	active site
164756000072	ATP binding site [chemical binding]; other site
164756000073	substrate binding site [chemical binding]; other site
164756000074	activation loop (A-loop); other site
164756000075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
164756000076	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
164756000077	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
164756000078	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
164756000079	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
164756000080	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756000081	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756000082	active site
164756000083	ATP binding site [chemical binding]; other site
164756000084	substrate binding site [chemical binding]; other site
164756000085	activation loop (A-loop); other site
164756000086	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
164756000087	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
164756000088	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
164756000089	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
164756000090	active site
164756000091	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
164756000092	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
164756000093	phosphopeptide binding site; other site
164756000094	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
164756000095	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
164756000096	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
164756000097	phosphopeptide binding site; other site
164756000098	HsdM N-terminal domain; Region: HsdM_N; pfam12161
164756000099	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
164756000100	Methyltransferase domain; Region: Methyltransf_26; pfam13659
164756000101	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
164756000102	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
164756000103	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
164756000104	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
164756000105	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756000106	ATP binding site [chemical binding]; other site
164756000107	putative Mg++ binding site [ion binding]; other site
164756000108	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
164756000109	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
164756000110	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
164756000111	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
164756000112	ligand binding site [chemical binding]; other site
164756000113	active site
164756000114	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
164756000115	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756000116	active site
164756000117	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
164756000118	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
164756000119	active site
164756000120	catalytic tetrad [active]
164756000121	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000122	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000123	hypothetical protein; Validated; Region: PRK07581
164756000124	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
164756000125	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000126	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000127	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
164756000128	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
164756000129	putative NADP binding site [chemical binding]; other site
164756000130	putative substrate binding site [chemical binding]; other site
164756000131	active site
164756000132	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000133	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756000134	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000135	active site
164756000136	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000137	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000138	active site
164756000139	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
164756000140	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756000141	active site
164756000142	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
164756000143	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756000144	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
164756000145	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756000146	NAD(P) binding site [chemical binding]; other site
164756000147	active site
164756000148	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
164756000149	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
164756000150	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
164756000151	DNA binding residues [nucleotide binding]
164756000152	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
164756000153	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
164756000154	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
164756000155	phosphopeptide binding site; other site
164756000156	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
164756000157	Domain of unknown function (DUF385); Region: DUF385; pfam04075
164756000158	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
164756000159	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756000160	PHB binding site; other site
164756000161	CoenzymeA binding site [chemical binding]; other site
164756000162	subunit interaction site [polypeptide binding]; other site
164756000163	Predicted acetyltransferase [General function prediction only]; Region: COG2388
164756000164	hypothetical protein; Provisional; Region: PRK02268
164756000165	DivIVA domain; Region: DivI1A_domain; TIGR03544
164756000166	DivIVA domain; Region: DivI1A_domain; TIGR03544
164756000167	Transcription factor WhiB; Region: Whib; pfam02467
164756000168	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
164756000169	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
164756000170	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
164756000171	EspG family; Region: ESX-1_EspG; pfam14011
164756000172	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
164756000173	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756000174	Walker A motif; other site
164756000175	ATP binding site [chemical binding]; other site
164756000176	Walker B motif; other site
164756000177	arginine finger; other site
164756000178	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
164756000179	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
164756000180	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756000181	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
164756000182	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756000183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756000184	Walker A motif; other site
164756000185	ATP binding site [chemical binding]; other site
164756000186	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
164756000187	PPE family; Region: PPE; pfam00823
164756000188	Proteins of 100 residues with WXG; Region: WXG100; cl02005
164756000189	Proteins of 100 residues with WXG; Region: WXG100; cl02005
164756000190	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
164756000191	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
164756000192	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
164756000193	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
164756000194	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
164756000195	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
164756000196	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
164756000197	active site
164756000198	catalytic residues [active]
164756000199	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
164756000200	dimerization domain swap beta strand [polypeptide binding]; other site
164756000201	regulatory protein interface [polypeptide binding]; other site
164756000202	active site
164756000203	regulatory phosphorylation site [posttranslational modification]; other site
164756000204	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
164756000205	active site
164756000206	phosphorylation site [posttranslational modification]
164756000207	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
164756000208	active site
164756000209	P-loop; other site
164756000210	phosphorylation site [posttranslational modification]
164756000211	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
164756000212	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
164756000213	putative substrate binding site [chemical binding]; other site
164756000214	putative ATP binding site [chemical binding]; other site
164756000215	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
164756000216	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
164756000217	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
164756000218	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
164756000219	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
164756000220	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
164756000221	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
164756000222	Pirin-related protein [General function prediction only]; Region: COG1741
164756000223	Pirin; Region: Pirin; pfam02678
164756000224	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
164756000225	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
164756000226	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000227	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000228	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000229	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000230	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756000231	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
164756000232	Leucine carboxyl methyltransferase; Region: LCM; cl01306
164756000233	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756000234	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
164756000235	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
164756000236	NAD(P) binding site [chemical binding]; other site
164756000237	catalytic residues [active]
164756000238	short chain dehydrogenase; Provisional; Region: PRK07791
164756000239	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
164756000240	NAD binding site [chemical binding]; other site
164756000241	homodimer interface [polypeptide binding]; other site
164756000242	active site
164756000243	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
164756000244	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
164756000245	NAD(P) binding site [chemical binding]; other site
164756000246	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
164756000247	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756000248	motif II; other site
164756000249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756000250	S-adenosylmethionine binding site [chemical binding]; other site
164756000251	Protein of unknown function (DUF456); Region: DUF456; pfam04306
164756000252	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
164756000253	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
164756000254	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000255	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000256	active site
164756000257	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000258	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000259	active site
164756000260	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
164756000261	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
164756000262	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
164756000263	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
164756000264	ligand binding site [chemical binding]; other site
164756000265	homodimer interface [polypeptide binding]; other site
164756000266	NAD(P) binding site [chemical binding]; other site
164756000267	trimer interface B [polypeptide binding]; other site
164756000268	trimer interface A [polypeptide binding]; other site
164756000269	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
164756000270	short chain dehydrogenase; Provisional; Region: PRK07806
164756000271	glucose-1-dehydrogenase; Provisional; Region: PRK06947
164756000272	NAD(P) binding site [chemical binding]; other site
164756000273	active site
164756000274	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
164756000275	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
164756000276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756000277	dimer interface [polypeptide binding]; other site
164756000278	conserved gate region; other site
164756000279	putative PBP binding loops; other site
164756000280	ABC-ATPase subunit interface; other site
164756000281	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
164756000282	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756000283	substrate binding pocket [chemical binding]; other site
164756000284	membrane-bound complex binding site; other site
164756000285	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
164756000286	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
164756000287	Walker A/P-loop; other site
164756000288	ATP binding site [chemical binding]; other site
164756000289	Q-loop/lid; other site
164756000290	ABC transporter signature motif; other site
164756000291	Walker B; other site
164756000292	D-loop; other site
164756000293	H-loop/switch region; other site
164756000294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000296	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000297	active site
164756000298	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
164756000299	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
164756000300	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
164756000301	NAD(P) binding site [chemical binding]; other site
164756000302	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
164756000303	active site
164756000304	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
164756000305	putative hydrophobic ligand binding site [chemical binding]; other site
164756000306	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756000307	DNA-binding site [nucleotide binding]; DNA binding site
164756000308	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
164756000309	FCD domain; Region: FCD; pfam07729
164756000310	Restriction endonuclease; Region: Mrr_cat; pfam04471
164756000311	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
164756000312	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756000313	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756000314	acyl-activating enzyme (AAE) consensus motif; other site
164756000315	putative AMP binding site [chemical binding]; other site
164756000316	putative active site [active]
164756000317	putative CoA binding site [chemical binding]; other site
164756000318	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756000319	Permease; Region: Permease; pfam02405
164756000320	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756000321	Permease; Region: Permease; pfam02405
164756000322	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000323	mce related protein; Region: MCE; pfam02470
164756000324	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756000325	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000326	mce related protein; Region: MCE; pfam02470
164756000327	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756000328	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000329	mce related protein; Region: MCE; pfam02470
164756000330	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
164756000331	mce related protein; Region: MCE; pfam02470
164756000332	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000333	mce related protein; Region: MCE; pfam02470
164756000334	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000335	mce related protein; Region: MCE; pfam02470
164756000336	RDD family; Region: RDD; pfam06271
164756000337	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
164756000338	Phosphotransferase enzyme family; Region: APH; pfam01636
164756000339	Fructosamine kinase; Region: Fructosamin_kin; cl17579
164756000340	PE-PPE domain; Region: PE-PPE; pfam08237
164756000341	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756000342	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
164756000343	Predicted membrane protein [Function unknown]; Region: COG2261
164756000344	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
164756000345	Pirin-related protein [General function prediction only]; Region: COG1741
164756000346	Pirin; Region: Pirin; pfam02678
164756000347	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756000348	MarR family; Region: MarR_2; pfam12802
164756000349	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
164756000350	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
164756000351	NAD binding site [chemical binding]; other site
164756000352	catalytic Zn binding site [ion binding]; other site
164756000353	substrate binding site [chemical binding]; other site
164756000354	structural Zn binding site [ion binding]; other site
164756000355	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
164756000356	putative active site [active]
164756000357	RNA polymerase factor sigma-70; Validated; Region: PRK08241
164756000358	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756000359	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756000360	DNA binding residues [nucleotide binding]
164756000361	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756000362	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
164756000363	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756000364	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
164756000365	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
164756000366	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
164756000367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756000368	S-adenosylmethionine binding site [chemical binding]; other site
164756000369	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756000370	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
164756000371	Domain of unknown function (DUF305); Region: DUF305; pfam03713
164756000372	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
164756000373	putative homodimer interface [polypeptide binding]; other site
164756000374	putative homotetramer interface [polypeptide binding]; other site
164756000375	putative allosteric switch controlling residues; other site
164756000376	putative metal binding site [ion binding]; other site
164756000377	putative homodimer-homodimer interface [polypeptide binding]; other site
164756000378	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
164756000379	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
164756000380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756000381	putative substrate translocation pore; other site
164756000382	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
164756000383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
164756000384	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
164756000385	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
164756000386	MoxR-like ATPases [General function prediction only]; Region: COG0714
164756000387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756000388	Walker A motif; other site
164756000389	ATP binding site [chemical binding]; other site
164756000390	Walker B motif; other site
164756000391	arginine finger; other site
164756000392	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
164756000393	Protein of unknown function DUF58; Region: DUF58; pfam01882
164756000394	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
164756000395	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
164756000396	active site
164756000397	Zn binding site [ion binding]; other site
164756000398	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
164756000399	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
164756000400	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
164756000401	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
164756000402	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756000403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756000404	active site
164756000405	phosphorylation site [posttranslational modification]
164756000406	intermolecular recognition site; other site
164756000407	dimerization interface [polypeptide binding]; other site
164756000408	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756000409	DNA binding site [nucleotide binding]
164756000410	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756000411	HAMP domain; Region: HAMP; pfam00672
164756000412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756000413	phosphorylation site [posttranslational modification]
164756000414	dimer interface [polypeptide binding]; other site
164756000415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756000416	ATP binding site [chemical binding]; other site
164756000417	Mg2+ binding site [ion binding]; other site
164756000418	G-X-G motif; other site
164756000419	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
164756000420	Predicted integral membrane protein [Function unknown]; Region: COG0392
164756000421	Domain of unknown function DUF20; Region: UPF0118; pfam01594
164756000422	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
164756000423	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756000424	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756000425	active site
164756000426	MMPL family; Region: MMPL; pfam03176
164756000427	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
164756000428	MMPL family; Region: MMPL; pfam03176
164756000429	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
164756000430	LabA_like proteins; Region: LabA_like; cd06167
164756000431	putative metal binding site [ion binding]; other site
164756000432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756000433	S-adenosylmethionine binding site [chemical binding]; other site
164756000434	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
164756000435	active site
164756000436	substrate-binding site [chemical binding]; other site
164756000437	metal-binding site [ion binding]
164756000438	GTP binding site [chemical binding]; other site
164756000439	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756000440	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
164756000441	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756000442	acyl-activating enzyme (AAE) consensus motif; other site
164756000443	putative AMP binding site [chemical binding]; other site
164756000444	putative active site [active]
164756000445	acyl-activating enzyme (AAE) consensus motif; other site
164756000446	putative CoA binding site [chemical binding]; other site
164756000447	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756000448	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756000449	substrate binding site [chemical binding]; other site
164756000450	oxyanion hole (OAH) forming residues; other site
164756000451	trimer interface [polypeptide binding]; other site
164756000452	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
164756000453	classical (c) SDRs; Region: SDR_c; cd05233
164756000454	NAD(P) binding site [chemical binding]; other site
164756000455	active site
164756000456	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
164756000457	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
164756000458	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
164756000459	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000460	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000461	active site
164756000462	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
164756000463	putative active site [active]
164756000464	putative catalytic site [active]
164756000465	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756000466	active site 2 [active]
164756000467	active site 1 [active]
164756000468	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756000469	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
164756000470	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756000471	active site
164756000472	Ion channel; Region: Ion_trans_2; pfam07885
164756000473	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
164756000474	tetramer interface [polypeptide binding]; other site
164756000475	active site
164756000476	Mg2+/Mn2+ binding site [ion binding]; other site
164756000477	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
164756000478	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
164756000479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756000480	NAD(P) binding site [chemical binding]; other site
164756000481	active site
164756000482	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
164756000483	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756000484	DNA-binding site [nucleotide binding]; DNA binding site
164756000485	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
164756000486	short chain dehydrogenase; Provisional; Region: PRK12829
164756000487	classical (c) SDRs; Region: SDR_c; cd05233
164756000488	NAD(P) binding site [chemical binding]; other site
164756000489	active site
164756000490	Phosphotransferase enzyme family; Region: APH; pfam01636
164756000491	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
164756000492	substrate binding site [chemical binding]; other site
164756000493	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
164756000494	putative hexamer interface [polypeptide binding]; other site
164756000495	putative hexagonal pore; other site
164756000496	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
164756000497	putative hexamer interface [polypeptide binding]; other site
164756000498	putative hexagonal pore; other site
164756000499	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
164756000500	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
164756000501	Hexamer interface [polypeptide binding]; other site
164756000502	Hexagonal pore residue; other site
164756000503	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
164756000504	Hexamer/Pentamer interface [polypeptide binding]; other site
164756000505	central pore; other site
164756000506	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
164756000507	putative hexamer interface [polypeptide binding]; other site
164756000508	putative hexagonal pore; other site
164756000509	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
164756000510	putative hexamer interface [polypeptide binding]; other site
164756000511	putative hexagonal pore; other site
164756000512	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
164756000513	putative catalytic cysteine [active]
164756000514	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
164756000515	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756000516	inhibitor-cofactor binding pocket; inhibition site
164756000517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756000518	catalytic residue [active]
164756000519	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
164756000520	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756000521	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756000522	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000523	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000524	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000525	active site
164756000526	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
164756000527	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756000528	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756000529	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756000530	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756000531	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
164756000532	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756000533	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756000534	substrate binding pocket [chemical binding]; other site
164756000535	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756000536	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756000537	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
164756000538	putative acyl-acceptor binding pocket; other site
164756000539	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
164756000540	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
164756000541	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
164756000542	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000543	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000544	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000545	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000546	active site
164756000547	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756000548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756000549	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
164756000550	RibD C-terminal domain; Region: RibD_C; cl17279
164756000551	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000552	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000553	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
164756000554	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756000555	NAD binding site [chemical binding]; other site
164756000556	catalytic residues [active]
164756000557	Methyltransferase domain; Region: Methyltransf_11; pfam08241
164756000558	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756000559	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
164756000560	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
164756000561	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756000562	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
164756000563	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756000564	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756000565	putative AMP binding site [chemical binding]; other site
164756000566	putative active site [active]
164756000567	acyl-activating enzyme (AAE) consensus motif; other site
164756000568	putative CoA binding site [chemical binding]; other site
164756000569	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
164756000570	active site
164756000571	substrate binding pocket [chemical binding]; other site
164756000572	homodimer interaction site [polypeptide binding]; other site
164756000573	Transmembrane secretion effector; Region: MFS_3; pfam05977
164756000574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756000575	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
164756000576	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
164756000577	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
164756000578	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756000579	Ligand Binding Site [chemical binding]; other site
164756000580	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
164756000581	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
164756000582	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
164756000583	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
164756000584	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756000585	catalytic residue [active]
164756000586	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
164756000587	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756000588	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
164756000589	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
164756000590	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756000591	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
164756000592	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
164756000593	putative dimer interface [polypeptide binding]; other site
164756000594	putative active site [active]
164756000595	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
164756000596	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
164756000597	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
164756000598	putative active site [active]
164756000599	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000600	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000601	O-methyltransferase; Region: Methyltransf_2; pfam00891
164756000602	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756000603	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756000604	active site 2 [active]
164756000605	active site 1 [active]
164756000606	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
164756000607	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756000608	NAD(P) binding site [chemical binding]; other site
164756000609	active site
164756000610	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
164756000611	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756000612	dimer interface [polypeptide binding]; other site
164756000613	active site
164756000614	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
164756000615	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
164756000616	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
164756000617	FAD binding site [chemical binding]; other site
164756000618	substrate binding site [chemical binding]; other site
164756000619	catalytic residues [active]
164756000620	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
164756000621	GAF domain; Region: GAF; cl17456
164756000622	ANTAR domain; Region: ANTAR; pfam03861
164756000623	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
164756000624	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756000625	active site
164756000626	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
164756000627	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756000628	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
164756000629	KR domain; Region: KR; pfam08659
164756000630	NADP binding site [chemical binding]; other site
164756000631	active site
164756000632	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756000633	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
164756000634	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756000635	active site
164756000636	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756000637	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
164756000638	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756000639	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
164756000640	Enoylreductase; Region: PKS_ER; smart00829
164756000641	NAD(P) binding site [chemical binding]; other site
164756000642	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
164756000643	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
164756000644	putative NADP binding site [chemical binding]; other site
164756000645	active site
164756000646	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756000647	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
164756000648	acyl-CoA synthetase; Validated; Region: PRK05850
164756000649	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
164756000650	acyl-activating enzyme (AAE) consensus motif; other site
164756000651	active site
164756000652	PE-PPE domain; Region: PE-PPE; pfam08237
164756000653	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
164756000654	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
164756000655	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
164756000656	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756000657	catalytic loop [active]
164756000658	iron binding site [ion binding]; other site
164756000659	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
164756000660	L-aspartate oxidase; Provisional; Region: PRK06175
164756000661	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
164756000662	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
164756000663	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
164756000664	tetramer interface [polypeptide binding]; other site
164756000665	active site
164756000666	Mg2+/Mn2+ binding site [ion binding]; other site
164756000667	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
164756000668	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
164756000669	putative dimer interface [polypeptide binding]; other site
164756000670	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
164756000671	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756000672	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
164756000673	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
164756000674	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
164756000675	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
164756000676	GAF domain; Region: GAF_2; pfam13185
164756000677	ANTAR domain; Region: ANTAR; pfam03861
164756000678	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
164756000679	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
164756000680	putative active site [active]
164756000681	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
164756000682	putative active site [active]
164756000683	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
164756000684	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
164756000685	active site
164756000686	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
164756000687	DNA binding site [nucleotide binding]
164756000688	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
164756000689	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756000690	Coenzyme A binding pocket [chemical binding]; other site
164756000691	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756000692	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756000693	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
164756000694	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
164756000695	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
164756000696	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
164756000697	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
164756000698	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
164756000699	intersubunit interface [polypeptide binding]; other site
164756000700	short chain dehydrogenase; Provisional; Region: PRK08267
164756000701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756000702	NAD(P) binding site [chemical binding]; other site
164756000703	active site
164756000704	Lysine efflux permease [General function prediction only]; Region: COG1279
164756000705	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756000706	Permease; Region: Permease; pfam02405
164756000707	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756000708	Permease; Region: Permease; pfam02405
164756000709	mce related protein; Region: MCE; pfam02470
164756000710	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756000711	mce related protein; Region: MCE; pfam02470
164756000712	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000713	mce related protein; Region: MCE; pfam02470
164756000714	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756000715	mce related protein; Region: MCE; pfam02470
164756000716	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000717	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000718	mce related protein; Region: MCE; pfam02470
164756000719	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756000720	mce related protein; Region: MCE; pfam02470
164756000721	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756000722	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756000723	CoenzymeA binding site [chemical binding]; other site
164756000724	subunit interaction site [polypeptide binding]; other site
164756000725	PHB binding site; other site
164756000726	3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837
164756000727	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756000728	Predicted transcriptional regulators [Transcription]; Region: COG1695
164756000729	Transcriptional regulator PadR-like family; Region: PadR; cl17335
164756000730	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
164756000731	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
164756000732	active site
164756000733	FMN binding site [chemical binding]; other site
164756000734	substrate binding site [chemical binding]; other site
164756000735	putative catalytic residue [active]
164756000736	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756000737	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756000738	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756000739	classical (c) SDRs; Region: SDR_c; cd05233
164756000740	NAD(P) binding site [chemical binding]; other site
164756000741	active site
164756000742	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845
164756000743	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756000744	short chain dehydrogenase; Provisional; Region: PRK12828
164756000745	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756000746	NAD(P) binding site [chemical binding]; other site
164756000747	active site
164756000748	SnoaL-like domain; Region: SnoaL_4; pfam13577
164756000749	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756000750	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
164756000751	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756000752	hydrophobic ligand binding site; other site
164756000753	short chain dehydrogenase; Provisional; Region: PRK12828
164756000754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756000755	NAD(P) binding site [chemical binding]; other site
164756000756	active site
164756000757	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756000758	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756000759	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756000760	hypothetical protein; Validated; Region: PRK07121
164756000761	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756000762	classical (c) SDRs; Region: SDR_c; cd05233
164756000763	short chain dehydrogenase; Provisional; Region: PRK08267
164756000764	NAD(P) binding site [chemical binding]; other site
164756000765	active site
164756000766	classical (c) SDRs; Region: SDR_c; cd05233
164756000767	NAD(P) binding site [chemical binding]; other site
164756000768	active site
164756000769	enoyl-CoA hydratase; Provisional; Region: PRK09245
164756000770	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756000771	substrate binding site [chemical binding]; other site
164756000772	oxyanion hole (OAH) forming residues; other site
164756000773	trimer interface [polypeptide binding]; other site
164756000774	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
164756000775	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756000776	NAD binding site [chemical binding]; other site
164756000777	catalytic residues [active]
164756000778	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
164756000779	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756000780	catalytic Zn binding site [ion binding]; other site
164756000781	structural Zn binding site [ion binding]; other site
164756000782	tetramer interface [polypeptide binding]; other site
164756000783	acyl-CoA synthetase; Validated; Region: PRK08316
164756000784	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756000785	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756000786	acyl-activating enzyme (AAE) consensus motif; other site
164756000787	putative AMP binding site [chemical binding]; other site
164756000788	putative active site [active]
164756000789	putative CoA binding site [chemical binding]; other site
164756000790	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756000791	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756000792	human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338
164756000793	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
164756000794	NAD(P) binding site [chemical binding]; other site
164756000795	homodimer interface [polypeptide binding]; other site
164756000796	active site
164756000797	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
164756000798	putative allyl alcohol dehydrogenase; Provisional; Region: PLN03154
164756000799	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756000800	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756000801	substrate binding pocket [chemical binding]; other site
164756000802	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756000803	Transcriptional regulator [Transcription]; Region: IclR; COG1414
164756000804	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
164756000805	Bacterial transcriptional regulator; Region: IclR; pfam01614
164756000806	hypothetical protein; Validated; Region: PRK07121
164756000807	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756000808	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
164756000809	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
164756000810	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
164756000811	active site
164756000812	Fe binding site [ion binding]; other site
164756000813	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000814	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000815	active site
164756000816	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
164756000817	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
164756000818	FAD binding pocket [chemical binding]; other site
164756000819	FAD binding motif [chemical binding]; other site
164756000820	phosphate binding motif [ion binding]; other site
164756000821	beta-alpha-beta structure motif; other site
164756000822	NAD(p) ribose binding residues [chemical binding]; other site
164756000823	NAD binding pocket [chemical binding]; other site
164756000824	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
164756000825	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756000826	catalytic loop [active]
164756000827	iron binding site [ion binding]; other site
164756000828	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756000829	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756000830	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
164756000831	classical (c) SDRs; Region: SDR_c; cd05233
164756000832	NAD(P) binding site [chemical binding]; other site
164756000833	active site
164756000834	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756000835	classical (c) SDRs; Region: SDR_c; cd05233
164756000836	NAD(P) binding site [chemical binding]; other site
164756000837	active site
164756000838	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
164756000839	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
164756000840	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000841	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000842	metabolite-proton symporter; Region: 2A0106; TIGR00883
164756000843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756000844	putative substrate translocation pore; other site
164756000845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756000846	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
164756000847	NAD(P) binding site [chemical binding]; other site
164756000848	active site
164756000849	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756000850	Ligand Binding Site [chemical binding]; other site
164756000851	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756000852	Ligand Binding Site [chemical binding]; other site
164756000853	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756000854	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756000855	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756000856	classical (c) SDRs; Region: SDR_c; cd05233
164756000857	NAD(P) binding site [chemical binding]; other site
164756000858	active site
164756000859	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000860	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000861	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756000862	Cytochrome P450; Region: p450; cl12078
164756000863	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
164756000864	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
164756000865	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756000866	classical (c) SDRs; Region: SDR_c; cd05233
164756000867	NAD(P) binding site [chemical binding]; other site
164756000868	active site
164756000869	short chain dehydrogenase; Provisional; Region: PRK12827
164756000870	classical (c) SDRs; Region: SDR_c; cd05233
164756000871	NAD(P) binding site [chemical binding]; other site
164756000872	active site
164756000873	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000874	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000875	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
164756000876	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756000877	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756000878	active site
164756000879	Transcriptional regulators [Transcription]; Region: GntR; COG1802
164756000880	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756000881	DNA-binding site [nucleotide binding]; DNA binding site
164756000882	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
164756000883	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
164756000884	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
164756000885	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
164756000886	Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551
164756000887	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
164756000888	active site
164756000889	hypothetical protein; Provisional; Region: PRK06062
164756000890	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756000891	inhibitor-cofactor binding pocket; inhibition site
164756000892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756000893	catalytic residue [active]
164756000894	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
164756000895	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
164756000896	tetrameric interface [polypeptide binding]; other site
164756000897	NAD binding site [chemical binding]; other site
164756000898	catalytic residues [active]
164756000899	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
164756000900	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
164756000901	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756000902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756000903	dimer interface [polypeptide binding]; other site
164756000904	phosphorylation site [posttranslational modification]
164756000905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756000906	ATP binding site [chemical binding]; other site
164756000907	Mg2+ binding site [ion binding]; other site
164756000908	G-X-G motif; other site
164756000909	Response regulator receiver domain; Region: Response_reg; pfam00072
164756000910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756000911	active site
164756000912	phosphorylation site [posttranslational modification]
164756000913	intermolecular recognition site; other site
164756000914	dimerization interface [polypeptide binding]; other site
164756000915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
164756000916	PAS domain; Region: PAS_9; pfam13426
164756000917	putative active site [active]
164756000918	heme pocket [chemical binding]; other site
164756000919	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
164756000920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
164756000921	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
164756000922	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756000923	anti sigma factor interaction site; other site
164756000924	regulatory phosphorylation site [posttranslational modification]; other site
164756000925	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
164756000926	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
164756000927	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
164756000928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756000929	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
164756000930	dimerization interface [polypeptide binding]; other site
164756000931	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
164756000932	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756000933	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756000934	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756000935	metal binding site [ion binding]; metal-binding site
164756000936	active site
164756000937	I-site; other site
164756000938	Putative transcription activator [Transcription]; Region: TenA; COG0819
164756000939	Methyltransferase domain; Region: Methyltransf_24; pfam13578
164756000940	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756000941	anti sigma factor interaction site; other site
164756000942	regulatory phosphorylation site [posttranslational modification]; other site
164756000943	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
164756000944	nucleotide binding site [chemical binding]; other site
164756000945	acyl-CoA synthetase; Validated; Region: PRK07788
164756000946	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756000947	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756000948	acyl-activating enzyme (AAE) consensus motif; other site
164756000949	acyl-activating enzyme (AAE) consensus motif; other site
164756000950	putative AMP binding site [chemical binding]; other site
164756000951	putative active site [active]
164756000952	putative CoA binding site [chemical binding]; other site
164756000953	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
164756000954	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
164756000955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756000956	putative substrate translocation pore; other site
164756000957	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
164756000958	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000959	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756000960	active site
164756000961	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756000962	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
164756000963	FAD binding site [chemical binding]; other site
164756000964	substrate binding site [chemical binding]; other site
164756000965	catalytic base [active]
164756000966	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756000967	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756000968	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
164756000969	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756000970	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
164756000971	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
164756000972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756000973	Walker A motif; other site
164756000974	ATP binding site [chemical binding]; other site
164756000975	Walker B motif; other site
164756000976	arginine finger; other site
164756000977	Protein of unknown function (DUF690); Region: DUF690; cl04939
164756000978	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
164756000979	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756000980	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
164756000981	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756000982	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756000983	PE family; Region: PE; pfam00934
164756000984	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
164756000985	PPE family; Region: PPE; pfam00823
164756000986	Transposase; Region: DEDD_Tnp_IS110; pfam01548
164756000987	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
164756000988	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
164756000989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
164756000990	EspG family; Region: ESX-1_EspG; pfam14011
164756000991	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
164756000992	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
164756000993	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
164756000994	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
164756000995	active site
164756000996	catalytic residues [active]
164756000997	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
164756000998	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
164756000999	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
164756001000	NAD(P) binding site [chemical binding]; other site
164756001001	LDH/MDH dimer interface [polypeptide binding]; other site
164756001002	substrate binding site [chemical binding]; other site
164756001003	pyruvate kinase; Provisional; Region: PRK14725
164756001004	active site
164756001005	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
164756001006	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756001007	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
164756001008	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
164756001009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756001010	S-adenosylmethionine binding site [chemical binding]; other site
164756001011	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
164756001012	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
164756001013	CysD dimerization site [polypeptide binding]; other site
164756001014	G1 box; other site
164756001015	putative GEF interaction site [polypeptide binding]; other site
164756001016	GTP/Mg2+ binding site [chemical binding]; other site
164756001017	Switch I region; other site
164756001018	G2 box; other site
164756001019	G3 box; other site
164756001020	Switch II region; other site
164756001021	G4 box; other site
164756001022	G5 box; other site
164756001023	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
164756001024	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
164756001025	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
164756001026	ligand-binding site [chemical binding]; other site
164756001027	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
164756001028	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
164756001029	Active Sites [active]
164756001030	Stf0 sulphotransferase; Region: Sulphotransf; pfam09037
164756001031	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
164756001032	Sulfatase; Region: Sulfatase; pfam00884
164756001033	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
164756001034	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
164756001035	active site
164756001036	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
164756001037	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
164756001038	active site
164756001039	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
164756001040	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
164756001041	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756001042	putative DNA binding site [nucleotide binding]; other site
164756001043	putative Zn2+ binding site [ion binding]; other site
164756001044	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
164756001045	putative hydrophobic ligand binding site [chemical binding]; other site
164756001046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
164756001047	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
164756001048	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
164756001049	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756001050	iron-sulfur cluster [ion binding]; other site
164756001051	[2Fe-2S] cluster binding site [ion binding]; other site
164756001052	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756001053	nucleotide binding site [chemical binding]; other site
164756001054	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
164756001055	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
164756001056	putative di-iron ligands [ion binding]; other site
164756001057	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756001058	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756001059	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
164756001060	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
164756001061	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
164756001062	GAF domain; Region: GAF; pfam01590
164756001063	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
164756001064	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
164756001065	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
164756001066	DXD motif; other site
164756001067	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756001068	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
164756001069	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756001070	anti sigma factor interaction site; other site
164756001071	regulatory phosphorylation site [posttranslational modification]; other site
164756001072	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
164756001073	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
164756001074	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001075	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001076	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
164756001077	PE-PPE domain; Region: PE-PPE; pfam08237
164756001078	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
164756001079	active site
164756001080	catalytic residues [active]
164756001081	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
164756001082	PE-PPE domain; Region: PE-PPE; pfam08237
164756001083	PE-PPE domain; Region: PE-PPE; pfam08237
164756001084	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
164756001085	heme-binding site [chemical binding]; other site
164756001086	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
164756001087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756001088	NAD(P) binding site [chemical binding]; other site
164756001089	active site
164756001090	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756001091	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
164756001092	NAD(P) binding site [chemical binding]; other site
164756001093	active site
164756001094	Secretory lipase; Region: LIP; pfam03583
164756001095	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
164756001096	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
164756001097	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756001098	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756001099	active site
164756001100	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756001101	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756001102	dimerization interface [polypeptide binding]; other site
164756001103	DNA binding residues [nucleotide binding]
164756001104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756001105	S-adenosylmethionine binding site [chemical binding]; other site
164756001106	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
164756001107	trimer interface [polypeptide binding]; other site
164756001108	active site
164756001109	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
164756001110	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756001111	Cytochrome P450; Region: p450; cl12078
164756001112	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
164756001113	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
164756001114	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756001115	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
164756001116	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
164756001117	substrate binding site; other site
164756001118	tetramer interface; other site
164756001119	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
164756001120	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
164756001121	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
164756001122	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
164756001123	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
164756001124	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
164756001125	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756001126	catalytic loop [active]
164756001127	iron binding site [ion binding]; other site
164756001128	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
164756001129	YibE/F-like protein; Region: YibE_F; pfam07907
164756001130	aminotransferase AlaT; Validated; Region: PRK09265
164756001131	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756001132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756001133	homodimer interface [polypeptide binding]; other site
164756001134	catalytic residue [active]
164756001135	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
164756001136	4Fe-4S binding domain; Region: Fer4; cl02805
164756001137	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
164756001138	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
164756001139	4Fe-4S binding domain; Region: Fer4; pfam00037
164756001140	Cysteine-rich domain; Region: CCG; pfam02754
164756001141	Cysteine-rich domain; Region: CCG; pfam02754
164756001142	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756001143	dimerization interface [polypeptide binding]; other site
164756001144	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756001145	DNA binding residues [nucleotide binding]
164756001146	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756001147	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
164756001148	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
164756001149	G1 box; other site
164756001150	GTP/Mg2+ binding site [chemical binding]; other site
164756001151	G2 box; other site
164756001152	Switch I region; other site
164756001153	G3 box; other site
164756001154	Switch II region; other site
164756001155	G4 box; other site
164756001156	G5 box; other site
164756001157	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
164756001158	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
164756001159	G1 box; other site
164756001160	GTP/Mg2+ binding site [chemical binding]; other site
164756001161	G2 box; other site
164756001162	Switch I region; other site
164756001163	G3 box; other site
164756001164	Switch II region; other site
164756001165	G4 box; other site
164756001166	G5 box; other site
164756001167	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756001168	nucleotide binding site [chemical binding]; other site
164756001169	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
164756001170	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756001171	TIGR03085 family protein; Region: TIGR03085
164756001172	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
164756001173	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
164756001174	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
164756001175	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756001176	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
164756001177	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756001178	Domain of unknown function (DUF385); Region: DUF385; cl04387
164756001179	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
164756001180	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
164756001181	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
164756001182	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
164756001183	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
164756001184	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
164756001185	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
164756001186	nucleotide binding site [chemical binding]; other site
164756001187	NEF interaction site [polypeptide binding]; other site
164756001188	SBD interface [polypeptide binding]; other site
164756001189	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
164756001190	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
164756001191	dimer interface [polypeptide binding]; other site
164756001192	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
164756001193	chaperone protein DnaJ; Provisional; Region: PRK14279
164756001194	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
164756001195	HSP70 interaction site [polypeptide binding]; other site
164756001196	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
164756001197	Zn binding sites [ion binding]; other site
164756001198	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
164756001199	dimer interface [polypeptide binding]; other site
164756001200	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
164756001201	DNA binding residues [nucleotide binding]
164756001202	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756001203	putative dimer interface [polypeptide binding]; other site
164756001204	mannosyltransferase; Provisional; Region: pimE; PRK13375
164756001205	mannosyltransferase; Provisional; Region: pimE; PRK13375
164756001206	mannosyltransferase; Provisional; Region: pimE; PRK13375
164756001207	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
164756001208	active site
164756001209	catalytic residues [active]
164756001210	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
164756001211	heme-binding site [chemical binding]; other site
164756001212	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
164756001213	FMN reductase; Validated; Region: fre; PRK08051
164756001214	FAD binding pocket [chemical binding]; other site
164756001215	FAD binding motif [chemical binding]; other site
164756001216	phosphate binding motif [ion binding]; other site
164756001217	beta-alpha-beta structure motif; other site
164756001218	NAD binding pocket [chemical binding]; other site
164756001219	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001220	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001221	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
164756001222	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
164756001223	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
164756001224	Clp amino terminal domain; Region: Clp_N; pfam02861
164756001225	Clp amino terminal domain; Region: Clp_N; pfam02861
164756001226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756001227	Walker A motif; other site
164756001228	ATP binding site [chemical binding]; other site
164756001229	Walker B motif; other site
164756001230	arginine finger; other site
164756001231	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756001232	Walker A motif; other site
164756001233	ATP binding site [chemical binding]; other site
164756001234	Walker B motif; other site
164756001235	arginine finger; other site
164756001236	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
164756001237	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
164756001238	classical (c) SDRs; Region: SDR_c; cd05233
164756001239	NAD(P) binding site [chemical binding]; other site
164756001240	active site
164756001241	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
164756001242	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
164756001243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756001244	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756001245	putative substrate translocation pore; other site
164756001246	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756001247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001249	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
164756001250	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
164756001251	Thioredoxin; Region: Thioredoxin_4; pfam13462
164756001252	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
164756001253	Transcriptional regulator [Transcription]; Region: LysR; COG0583
164756001254	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756001255	LysR substrate binding domain; Region: LysR_substrate; pfam03466
164756001256	dimerization interface [polypeptide binding]; other site
164756001257	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
164756001258	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
164756001259	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
164756001260	XdhC Rossmann domain; Region: XdhC_C; pfam13478
164756001261	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
164756001262	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
164756001263	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
164756001264	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
164756001265	catalytic loop [active]
164756001266	iron binding site [ion binding]; other site
164756001267	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
164756001268	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
164756001269	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
164756001270	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
164756001271	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
164756001272	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
164756001273	XdhC Rossmann domain; Region: XdhC_C; pfam13478
164756001274	MoxR-like ATPases [General function prediction only]; Region: COG0714
164756001275	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
164756001276	putative hydrophobic ligand binding site [chemical binding]; other site
164756001277	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
164756001278	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
164756001279	metal ion-dependent adhesion site (MIDAS); other site
164756001280	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756001281	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
164756001282	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756001283	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
164756001284	short chain dehydrogenase; Validated; Region: PRK08264
164756001285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756001286	NAD(P) binding site [chemical binding]; other site
164756001287	active site
164756001288	Nitronate monooxygenase; Region: NMO; pfam03060
164756001289	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
164756001290	FMN binding site [chemical binding]; other site
164756001291	substrate binding site [chemical binding]; other site
164756001292	putative catalytic residue [active]
164756001293	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
164756001294	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
164756001295	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
164756001296	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
164756001297	NAD(P) binding site [chemical binding]; other site
164756001298	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
164756001299	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
164756001300	active site
164756001301	intersubunit interface [polypeptide binding]; other site
164756001302	zinc binding site [ion binding]; other site
164756001303	Na+ binding site [ion binding]; other site
164756001304	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
164756001305	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
164756001306	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
164756001307	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
164756001308	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
164756001309	Peptidase family M50; Region: Peptidase_M50; pfam02163
164756001310	active site
164756001311	putative substrate binding region [chemical binding]; other site
164756001312	Transcriptional regulators [Transcription]; Region: FadR; COG2186
164756001313	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756001314	DNA-binding site [nucleotide binding]; DNA binding site
164756001315	FCD domain; Region: FCD; pfam07729
164756001316	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
164756001317	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
164756001318	catalytic triad [active]
164756001319	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
164756001320	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
164756001321	active site
164756001322	metal binding site [ion binding]; metal-binding site
164756001323	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756001324	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756001325	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
164756001326	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
164756001327	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756001328	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
164756001329	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
164756001330	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
164756001331	GDP-binding site [chemical binding]; other site
164756001332	ACT binding site; other site
164756001333	IMP binding site; other site
164756001334	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756001335	CoenzymeA binding site [chemical binding]; other site
164756001336	subunit interaction site [polypeptide binding]; other site
164756001337	PHB binding site; other site
164756001338	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756001339	Cytochrome P450; Region: p450; cl12078
164756001340	MMPL family; Region: MMPL; pfam03176
164756001341	MMPL family; Region: MMPL; pfam03176
164756001342	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756001343	MarR family; Region: MarR_2; pfam12802
164756001344	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
164756001345	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
164756001346	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
164756001347	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756001348	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
164756001349	active site residue [active]
164756001350	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
164756001351	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
164756001352	homodimer interface [polypeptide binding]; other site
164756001353	substrate-cofactor binding pocket; other site
164756001354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756001355	catalytic residue [active]
164756001356	short chain dehydrogenase; Provisional; Region: PRK07825
164756001357	classical (c) SDRs; Region: SDR_c; cd05233
164756001358	NAD(P) binding site [chemical binding]; other site
164756001359	active site
164756001360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756001361	Coenzyme A binding pocket [chemical binding]; other site
164756001362	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756001363	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
164756001364	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
164756001365	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756001366	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
164756001367	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
164756001368	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
164756001369	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
164756001370	DXD motif; other site
164756001371	phosphate acetyltransferase; Reviewed; Region: PRK05632
164756001372	DRTGG domain; Region: DRTGG; pfam07085
164756001373	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
164756001374	propionate/acetate kinase; Provisional; Region: PRK12379
164756001375	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
164756001376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
164756001377	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756001378	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756001379	active site
164756001380	ATP binding site [chemical binding]; other site
164756001381	substrate binding site [chemical binding]; other site
164756001382	activation loop (A-loop); other site
164756001383	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756001384	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
164756001385	substrate binding pocket [chemical binding]; other site
164756001386	membrane-bound complex binding site; other site
164756001387	hinge residues; other site
164756001388	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
164756001389	nudix motif; other site
164756001390	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
164756001391	thiamine phosphate binding site [chemical binding]; other site
164756001392	active site
164756001393	pyrophosphate binding site [ion binding]; other site
164756001394	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
164756001395	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
164756001396	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
164756001397	thiS-thiF/thiG interaction site; other site
164756001398	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
164756001399	ThiS interaction site; other site
164756001400	putative active site [active]
164756001401	tetramer interface [polypeptide binding]; other site
164756001402	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
164756001403	active site
164756001404	catalytic triad [active]
164756001405	oxyanion hole [active]
164756001406	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
164756001407	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
164756001408	Walker A/P-loop; other site
164756001409	ATP binding site [chemical binding]; other site
164756001410	Q-loop/lid; other site
164756001411	ABC transporter signature motif; other site
164756001412	Walker B; other site
164756001413	D-loop; other site
164756001414	H-loop/switch region; other site
164756001415	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
164756001416	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
164756001417	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
164756001418	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
164756001419	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
164756001420	PA/protease or protease-like domain interface [polypeptide binding]; other site
164756001421	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
164756001422	active site
164756001423	metal binding site [ion binding]; metal-binding site
164756001424	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
164756001425	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
164756001426	PA/protease or protease-like domain interface [polypeptide binding]; other site
164756001427	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
164756001428	Peptidase family M28; Region: Peptidase_M28; pfam04389
164756001429	active site
164756001430	metal binding site [ion binding]; metal-binding site
164756001431	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
164756001432	amino acid transporter; Region: 2A0306; TIGR00909
164756001433	amino acid transporter; Region: 2A0306; TIGR00909
164756001434	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001435	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001436	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001438	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756001439	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756001440	Septum formation; Region: Septum_form; pfam13845
164756001441	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
164756001442	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
164756001443	dimer interface [polypeptide binding]; other site
164756001444	substrate binding site [chemical binding]; other site
164756001445	ATP binding site [chemical binding]; other site
164756001446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756001447	putative substrate translocation pore; other site
164756001448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756001449	AAA ATPase domain; Region: AAA_16; pfam13191
164756001450	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
164756001451	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756001452	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756001453	DNA binding residues [nucleotide binding]
164756001454	dimerization interface [polypeptide binding]; other site
164756001455	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
164756001456	putative catalytic site [active]
164756001457	putative phosphate binding site [ion binding]; other site
164756001458	active site
164756001459	metal binding site A [ion binding]; metal-binding site
164756001460	DNA binding site [nucleotide binding]
164756001461	putative AP binding site [nucleotide binding]; other site
164756001462	putative metal binding site B [ion binding]; other site
164756001463	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
164756001464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756001465	Coenzyme A binding pocket [chemical binding]; other site
164756001466	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
164756001467	active site
164756001468	catalytic residues [active]
164756001469	metal binding site [ion binding]; metal-binding site
164756001470	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
164756001471	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
164756001472	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
164756001473	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
164756001474	E-class dimer interface [polypeptide binding]; other site
164756001475	P-class dimer interface [polypeptide binding]; other site
164756001476	active site
164756001477	Cu2+ binding site [ion binding]; other site
164756001478	Zn2+ binding site [ion binding]; other site
164756001479	carboxylate-amine ligase; Provisional; Region: PRK13517
164756001480	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
164756001481	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
164756001482	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
164756001483	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756001484	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756001485	Leucine carboxyl methyltransferase; Region: LCM; cl01306
164756001486	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
164756001487	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
164756001488	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
164756001489	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
164756001490	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
164756001491	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
164756001492	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
164756001493	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
164756001494	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
164756001495	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
164756001496	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
164756001497	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
164756001498	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
164756001499	transmembrane helices; other site
164756001500	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
164756001501	FOG: CBS domain [General function prediction only]; Region: COG0517
164756001502	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
164756001503	Histidine kinase; Region: HisKA_3; pfam07730
164756001504	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
164756001505	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756001506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756001507	active site
164756001508	phosphorylation site [posttranslational modification]
164756001509	intermolecular recognition site; other site
164756001510	dimerization interface [polypeptide binding]; other site
164756001511	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756001512	DNA binding residues [nucleotide binding]
164756001513	dimerization interface [polypeptide binding]; other site
164756001514	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
164756001515	2TM domain; Region: 2TM; pfam13239
164756001516	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
164756001517	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
164756001518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756001519	Walker A motif; other site
164756001520	ATP binding site [chemical binding]; other site
164756001521	Walker B motif; other site
164756001522	arginine finger; other site
164756001523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756001524	Walker A motif; other site
164756001525	ATP binding site [chemical binding]; other site
164756001526	Walker B motif; other site
164756001527	arginine finger; other site
164756001528	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
164756001529	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
164756001530	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
164756001531	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
164756001532	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
164756001533	dimer interface [polypeptide binding]; other site
164756001534	putative functional site; other site
164756001535	putative MPT binding site; other site
164756001536	short chain dehydrogenase; Provisional; Region: PRK06197
164756001537	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
164756001538	putative NAD(P) binding site [chemical binding]; other site
164756001539	active site
164756001540	Uncharacterized conserved protein [Function unknown]; Region: COG3402
164756001541	Predicted membrane protein [Function unknown]; Region: COG3428
164756001542	Bacterial PH domain; Region: DUF304; pfam03703
164756001543	Bacterial PH domain; Region: DUF304; cl01348
164756001544	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
164756001545	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756001546	active site
164756001547	motif I; other site
164756001548	motif II; other site
164756001549	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756001550	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
164756001551	TrkA-N domain; Region: TrkA_N; pfam02254
164756001552	PAS domain; Region: PAS_9; pfam13426
164756001553	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756001554	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756001555	DNA binding residues [nucleotide binding]
164756001556	dimerization interface [polypeptide binding]; other site
164756001557	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
164756001558	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756001559	ATP binding site [chemical binding]; other site
164756001560	putative Mg++ binding site [ion binding]; other site
164756001561	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
164756001562	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
164756001563	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
164756001564	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756001565	ABC transporter signature motif; other site
164756001566	Walker B; other site
164756001567	D-loop; other site
164756001568	H-loop/switch region; other site
164756001569	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756001570	Walker A/P-loop; other site
164756001571	ATP binding site [chemical binding]; other site
164756001572	Q-loop/lid; other site
164756001573	ABC transporter signature motif; other site
164756001574	Walker B; other site
164756001575	D-loop; other site
164756001576	H-loop/switch region; other site
164756001577	Cupin domain; Region: Cupin_2; pfam07883
164756001578	short chain dehydrogenase; Provisional; Region: PRK06197
164756001579	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
164756001580	putative NAD(P) binding site [chemical binding]; other site
164756001581	active site
164756001582	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001583	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001584	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
164756001585	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
164756001586	ring oligomerisation interface [polypeptide binding]; other site
164756001587	ATP/Mg binding site [chemical binding]; other site
164756001588	stacking interactions; other site
164756001589	hinge regions; other site
164756001590	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
164756001591	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756001592	active site
164756001593	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756001594	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
164756001595	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756001596	Protein of unknown function (DUF664); Region: DUF664; pfam04978
164756001597	DinB superfamily; Region: DinB_2; pfam12867
164756001598	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756001599	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
164756001600	NAD(P) binding site [chemical binding]; other site
164756001601	catalytic residues [active]
164756001602	enoyl-CoA hydratase; Provisional; Region: PRK12478
164756001603	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756001604	substrate binding site [chemical binding]; other site
164756001605	oxyanion hole (OAH) forming residues; other site
164756001606	trimer interface [polypeptide binding]; other site
164756001607	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756001608	Cytochrome P450; Region: p450; cl12078
164756001609	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756001610	classical (c) SDRs; Region: SDR_c; cd05233
164756001611	NAD(P) binding site [chemical binding]; other site
164756001612	active site
164756001613	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
164756001614	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756001615	Cytochrome P450; Region: p450; cl12078
164756001616	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001617	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756001618	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756001619	active site
164756001620	Winged helix-turn helix; Region: HTH_29; pfam13551
164756001621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
164756001622	Integrase core domain; Region: rve; pfam00665
164756001623	Integrase core domain; Region: rve_3; pfam13683
164756001624	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
164756001625	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756001626	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756001627	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756001628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756001629	acetoin reductases; Region: 23BDH; TIGR02415
164756001630	NAD(P) binding site [chemical binding]; other site
164756001631	active site
164756001632	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
164756001633	GAF domain; Region: GAF; pfam01590
164756001634	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
164756001635	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756001636	NAD(P) binding site [chemical binding]; other site
164756001637	catalytic residues [active]
164756001638	Protein of unknown function (DUF779); Region: DUF779; pfam05610
164756001639	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
164756001640	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
164756001641	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756001642	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
164756001643	Uncharacterized conserved protein [Function unknown]; Region: COG2128
164756001644	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
164756001645	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
164756001646	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756001647	non-specific DNA binding site [nucleotide binding]; other site
164756001648	salt bridge; other site
164756001649	sequence-specific DNA binding site [nucleotide binding]; other site
164756001650	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
164756001651	Domain of unknown function (DUF955); Region: DUF955; pfam06114
164756001652	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
164756001653	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
164756001654	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756001655	active site 2 [active]
164756001656	active site 1 [active]
164756001657	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756001658	isocitrate lyase; Provisional; Region: PRK15063
164756001659	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
164756001660	tetramer interface [polypeptide binding]; other site
164756001661	active site
164756001662	Mg2+/Mn2+ binding site [ion binding]; other site
164756001663	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
164756001664	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
164756001665	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
164756001666	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
164756001667	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001668	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001669	Predicted membrane protein [Function unknown]; Region: COG2733
164756001670	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
164756001671	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756001672	non-specific DNA binding site [nucleotide binding]; other site
164756001673	salt bridge; other site
164756001674	sequence-specific DNA binding site [nucleotide binding]; other site
164756001675	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
164756001676	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
164756001677	deoxyribose-phosphate aldolase; Provisional; Region: PRK00507
164756001678	catalytic residue [active]
164756001679	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
164756001680	Predicted amidohydrolase [General function prediction only]; Region: COG0388
164756001681	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
164756001682	putative active site [active]
164756001683	catalytic triad [active]
164756001684	putative dimer interface [polypeptide binding]; other site
164756001685	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
164756001686	Na binding site [ion binding]; other site
164756001687	putative glycosylation site [posttranslational modification]; other site
164756001688	putative glycosylation site [posttranslational modification]; other site
164756001689	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
164756001690	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
164756001691	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
164756001692	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
164756001693	FAD binding domain; Region: FAD_binding_4; pfam01565
164756001694	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
164756001695	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
164756001696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
164756001697	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
164756001698	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
164756001699	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
164756001700	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756001701	NAD(P) binding site [chemical binding]; other site
164756001702	active site
164756001703	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
164756001704	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756001705	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
164756001706	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
164756001707	putative ADP-binding pocket [chemical binding]; other site
164756001708	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
164756001709	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756001710	catalytic core [active]
164756001711	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756001712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756001713	dimer interface [polypeptide binding]; other site
164756001714	phosphorylation site [posttranslational modification]
164756001715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756001716	ATP binding site [chemical binding]; other site
164756001717	G-X-G motif; other site
164756001718	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756001719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756001720	active site
164756001721	phosphorylation site [posttranslational modification]
164756001722	intermolecular recognition site; other site
164756001723	dimerization interface [polypeptide binding]; other site
164756001724	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756001725	DNA binding site [nucleotide binding]
164756001726	YCII-related domain; Region: YCII; cl00999
164756001727	exopolyphosphatase; Region: exo_poly_only; TIGR03706
164756001728	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
164756001729	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
164756001730	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
164756001731	DNA interaction; other site
164756001732	Metal-binding active site; metal-binding site
164756001733	AP (apurinic/apyrimidinic) site pocket; other site
164756001734	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
164756001735	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
164756001736	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
164756001737	DNA binding domain, excisionase family; Region: excise; TIGR01764
164756001738	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
164756001739	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
164756001740	putative NAD(P) binding site [chemical binding]; other site
164756001741	active site
164756001742	putative substrate binding site [chemical binding]; other site
164756001743	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756001744	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
164756001745	putative acyl-acceptor binding pocket; other site
164756001746	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
164756001747	active site
164756001748	catalytic site [active]
164756001749	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
164756001750	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756001751	motif II; other site
164756001752	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
164756001753	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
164756001754	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
164756001755	tRNA; other site
164756001756	putative tRNA binding site [nucleotide binding]; other site
164756001757	putative NADP binding site [chemical binding]; other site
164756001758	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
164756001759	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
164756001760	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
164756001761	domain interfaces; other site
164756001762	active site
164756001763	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
164756001764	homodimer interface [polypeptide binding]; other site
164756001765	active site
164756001766	SAM binding site [chemical binding]; other site
164756001767	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
164756001768	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
164756001769	active site
164756001770	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
164756001771	dimer interface [polypeptide binding]; other site
164756001772	active site
164756001773	Schiff base residues; other site
164756001774	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
164756001775	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001776	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001777	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
164756001778	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
164756001779	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756001780	inhibitor-cofactor binding pocket; inhibition site
164756001781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756001782	catalytic residue [active]
164756001783	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756001784	catalytic core [active]
164756001785	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
164756001786	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
164756001787	catalytic residues [active]
164756001788	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
164756001789	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
164756001790	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
164756001791	ResB-like family; Region: ResB; pfam05140
164756001792	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
164756001793	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
164756001794	AAA domain; Region: AAA_31; pfam13614
164756001795	P-loop; other site
164756001796	Magnesium ion binding site [ion binding]; other site
164756001797	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
164756001798	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
164756001799	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756001800	catalytic residue [active]
164756001801	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
164756001802	Homeodomain-like domain; Region: HTH_23; cl17451
164756001803	Clp amino terminal domain; Region: Clp_N; pfam02861
164756001804	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
164756001805	UbiA prenyltransferase family; Region: UbiA; pfam01040
164756001806	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
164756001807	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
164756001808	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756001809	NAD(P) binding site [chemical binding]; other site
164756001810	active site
164756001811	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
164756001812	Nitronate monooxygenase; Region: NMO; pfam03060
164756001813	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
164756001814	FMN binding site [chemical binding]; other site
164756001815	substrate binding site [chemical binding]; other site
164756001816	putative catalytic residue [active]
164756001817	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
164756001818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756001819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756001820	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756001821	dimer interface [polypeptide binding]; other site
164756001822	phosphorylation site [posttranslational modification]
164756001823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756001824	ATP binding site [chemical binding]; other site
164756001825	Mg2+ binding site [ion binding]; other site
164756001826	G-X-G motif; other site
164756001827	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756001828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756001829	active site
164756001830	phosphorylation site [posttranslational modification]
164756001831	intermolecular recognition site; other site
164756001832	dimerization interface [polypeptide binding]; other site
164756001833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756001834	DNA binding site [nucleotide binding]
164756001835	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
164756001836	Ligand binding site; other site
164756001837	Putative Catalytic site; other site
164756001838	DXD motif; other site
164756001839	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
164756001840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
164756001841	S-adenosylmethionine binding site [chemical binding]; other site
164756001842	Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174
164756001843	Moco binding site; other site
164756001844	metal coordination site [ion binding]; other site
164756001845	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
164756001846	cyanate hydratase; Validated; Region: PRK02866
164756001847	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
164756001848	oligomer interface [polypeptide binding]; other site
164756001849	active site
164756001850	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
164756001851	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
164756001852	putative molybdopterin cofactor binding site [chemical binding]; other site
164756001853	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
164756001854	putative molybdopterin cofactor binding site; other site
164756001855	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756001856	Ligand Binding Site [chemical binding]; other site
164756001857	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756001858	Ligand Binding Site [chemical binding]; other site
164756001859	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
164756001860	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756001861	dimerization interface [polypeptide binding]; other site
164756001862	putative DNA binding site [nucleotide binding]; other site
164756001863	Predicted transcriptional regulator [Transcription]; Region: COG2345
164756001864	putative Zn2+ binding site [ion binding]; other site
164756001865	Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990
164756001866	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
164756001867	Protein of unknown function (DUF3140); Region: DUF3140; pfam11338
164756001868	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
164756001869	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756001870	active site
164756001871	CoA binding site [chemical binding]; other site
164756001872	AMP binding site [chemical binding]; other site
164756001873	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
164756001874	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
164756001875	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
164756001876	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756001877	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
164756001878	active site
164756001879	short chain dehydrogenase; Provisional; Region: PRK05866
164756001880	classical (c) SDRs; Region: SDR_c; cd05233
164756001881	NAD(P) binding site [chemical binding]; other site
164756001882	active site
164756001883	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001884	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001885	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
164756001886	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756001887	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
164756001888	substrate binding site [chemical binding]; other site
164756001889	oxyanion hole (OAH) forming residues; other site
164756001890	trimer interface [polypeptide binding]; other site
164756001891	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
164756001892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756001893	motif II; other site
164756001894	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
164756001895	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756001896	DNA binding residues [nucleotide binding]
164756001897	acyl-CoA synthetase; Validated; Region: PRK06188
164756001898	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756001899	putative active site [active]
164756001900	putative CoA binding site [chemical binding]; other site
164756001901	putative AMP binding site [chemical binding]; other site
164756001902	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
164756001903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
164756001904	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
164756001905	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
164756001906	active site
164756001907	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
164756001908	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756001909	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756001910	acyl-activating enzyme (AAE) consensus motif; other site
164756001911	acyl-activating enzyme (AAE) consensus motif; other site
164756001912	putative AMP binding site [chemical binding]; other site
164756001913	putative active site [active]
164756001914	putative CoA binding site [chemical binding]; other site
164756001915	O-succinylbenzoate synthase; Provisional; Region: PRK02901
164756001916	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
164756001917	active site
164756001918	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
164756001919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756001920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756001921	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
164756001922	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
164756001923	conserved cys residue [active]
164756001924	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756001925	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
164756001926	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
164756001927	conserved cys residue [active]
164756001928	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
164756001929	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756001930	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
164756001931	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
164756001932	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
164756001933	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
164756001934	dimer interface [polypeptide binding]; other site
164756001935	tetramer interface [polypeptide binding]; other site
164756001936	PYR/PP interface [polypeptide binding]; other site
164756001937	TPP binding site [chemical binding]; other site
164756001938	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
164756001939	TPP-binding site; other site
164756001940	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
164756001941	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756001942	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
164756001943	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756001944	NAD binding site [chemical binding]; other site
164756001945	catalytic Zn binding site [ion binding]; other site
164756001946	structural Zn binding site [ion binding]; other site
164756001947	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
164756001948	catalytic residues [active]
164756001949	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_3; cd06228
164756001950	putative active site [active]
164756001951	Zn binding site [ion binding]; other site
164756001952	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756001953	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
164756001954	short chain dehydrogenase; Provisional; Region: PRK08263
164756001955	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
164756001956	NADP binding site [chemical binding]; other site
164756001957	active site
164756001958	steroid binding site; other site
164756001959	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
164756001960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756001961	S-adenosylmethionine binding site [chemical binding]; other site
164756001962	Uncharacterized conserved protein [Function unknown]; Region: COG3349
164756001963	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756001964	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
164756001965	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
164756001966	putative active site [active]
164756001967	metal binding site [ion binding]; metal-binding site
164756001968	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
164756001969	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
164756001970	Predicted membrane protein [Function unknown]; Region: COG2860
164756001971	UPF0126 domain; Region: UPF0126; pfam03458
164756001972	UPF0126 domain; Region: UPF0126; pfam03458
164756001973	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
164756001974	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
164756001975	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
164756001976	putative active site [active]
164756001977	catalytic site [active]
164756001978	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
164756001979	putative active site [active]
164756001980	catalytic site [active]
164756001981	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
164756001982	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756001983	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
164756001984	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
164756001985	substrate binding pocket [chemical binding]; other site
164756001986	chain length determination region; other site
164756001987	substrate-Mg2+ binding site; other site
164756001988	catalytic residues [active]
164756001989	aspartate-rich region 1; other site
164756001990	active site lid residues [active]
164756001991	aspartate-rich region 2; other site
164756001992	heat shock protein HtpX; Provisional; Region: PRK03072
164756001993	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
164756001994	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
164756001995	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
164756001996	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
164756001997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
164756001998	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
164756001999	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
164756002000	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
164756002001	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
164756002002	FOG: PKD repeat [General function prediction only]; Region: COG3291
164756002003	AAA ATPase domain; Region: AAA_16; pfam13191
164756002004	Tetratricopeptide repeat; Region: TPR_12; pfam13424
164756002005	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756002006	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756002007	DNA binding residues [nucleotide binding]
164756002008	dimerization interface [polypeptide binding]; other site
164756002009	MarR family; Region: MarR_2; pfam12802
164756002010	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756002011	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756002012	active site
164756002013	ATP binding site [chemical binding]; other site
164756002014	substrate binding site [chemical binding]; other site
164756002015	activation loop (A-loop); other site
164756002016	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756002017	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
164756002018	substrate binding pocket [chemical binding]; other site
164756002019	membrane-bound complex binding site; other site
164756002020	hinge residues; other site
164756002021	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
164756002022	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
164756002023	dimer interface [polypeptide binding]; other site
164756002024	active site
164756002025	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
164756002026	PEGA domain; Region: PEGA; pfam08308
164756002027	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756002028	Cytochrome P450; Region: p450; cl12078
164756002029	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
164756002030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756002031	S-adenosylmethionine binding site [chemical binding]; other site
164756002032	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
164756002033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756002034	S-adenosylmethionine binding site [chemical binding]; other site
164756002035	N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181
164756002036	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
164756002037	putative active site [active]
164756002038	putative ligand binding site [chemical binding]; other site
164756002039	putative NAD(P) binding site [chemical binding]; other site
164756002040	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
164756002041	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756002042	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756002043	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756002044	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756002045	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756002046	active site
164756002047	ATP binding site [chemical binding]; other site
164756002048	substrate binding site [chemical binding]; other site
164756002049	activation loop (A-loop); other site
164756002050	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756002051	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756002052	cyclase homology domain; Region: CHD; cd07302
164756002053	nucleotidyl binding site; other site
164756002054	metal binding site [ion binding]; metal-binding site
164756002055	dimer interface [polypeptide binding]; other site
164756002056	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
164756002057	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
164756002058	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
164756002059	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756002060	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
164756002061	Part of AAA domain; Region: AAA_19; pfam13245
164756002062	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
164756002063	AAA domain; Region: AAA_12; pfam13087
164756002064	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
164756002065	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
164756002066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756002067	ATP binding site [chemical binding]; other site
164756002068	putative Mg++ binding site [ion binding]; other site
164756002069	helicase superfamily c-terminal domain; Region: HELICc; smart00490
164756002070	ATP-binding site [chemical binding]; other site
164756002071	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
164756002072	Uncharacterized conserved protein [Function unknown]; Region: COG1479
164756002073	Protein of unknown function DUF262; Region: DUF262; pfam03235
164756002074	Uncharacterized conserved protein [Function unknown]; Region: COG3472
164756002075	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
164756002076	Family description; Region: UvrD_C_2; pfam13538
164756002077	DEAD-like helicases superfamily; Region: DEXDc; smart00487
164756002078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756002079	ATP binding site [chemical binding]; other site
164756002080	putative Mg++ binding site [ion binding]; other site
164756002081	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756002082	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
164756002083	nucleotide binding region [chemical binding]; other site
164756002084	ATP-binding site [chemical binding]; other site
164756002085	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
164756002086	ATP-binding site [chemical binding]; other site
164756002087	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
164756002088	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132
164756002089	putative active site [active]
164756002090	putative catalytic site [active]
164756002091	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
164756002092	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
164756002093	cofactor binding site; other site
164756002094	DNA binding site [nucleotide binding]
164756002095	substrate interaction site [chemical binding]; other site
164756002096	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
164756002097	additional DNA contacts [nucleotide binding]; other site
164756002098	mismatch recognition site; other site
164756002099	active site
164756002100	zinc binding site [ion binding]; other site
164756002101	DNA intercalation site [nucleotide binding]; other site
164756002102	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
164756002103	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
164756002104	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
164756002105	putative active site [active]
164756002106	Nuclease-related domain; Region: NERD; pfam08378
164756002107	Part of AAA domain; Region: AAA_19; pfam13245
164756002108	Family description; Region: UvrD_C_2; pfam13538
164756002109	5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736
164756002110	Mrr N-terminal domain; Region: Mrr_N; pfam14338
164756002111	5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331
164756002112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756002113	Walker A motif; other site
164756002114	ATP binding site [chemical binding]; other site
164756002115	Walker B motif; other site
164756002116	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
164756002117	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
164756002118	active site
164756002119	catalytic residues [active]
164756002120	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
164756002121	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
164756002122	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
164756002123	nudix motif; other site
164756002124	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
164756002125	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002126	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002127	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756002128	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
164756002129	NAD(P) binding site [chemical binding]; other site
164756002130	active site
164756002131	Fic/DOC family; Region: Fic; cl00960
164756002132	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756002133	MULE transposase domain; Region: MULE; pfam10551
164756002134	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756002135	MULE transposase domain; Region: MULE; pfam10551
164756002136	Transposase; Region: HTH_Tnp_1; pfam01527
164756002137	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
164756002138	Mechanosensitive ion channel; Region: MS_channel; pfam00924
164756002139	SIR2-like domain; Region: SIR2_2; pfam13289
164756002140	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
164756002141	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
164756002142	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
164756002143	protein binding site [polypeptide binding]; other site
164756002144	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
164756002145	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
164756002146	EamA-like transporter family; Region: EamA; pfam00892
164756002147	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
164756002148	EamA-like transporter family; Region: EamA; pfam00892
164756002149	short chain dehydrogenase; Provisional; Region: PRK05866
164756002150	classical (c) SDRs; Region: SDR_c; cd05233
164756002151	NAD(P) binding site [chemical binding]; other site
164756002152	active site
164756002153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
164756002154	Microsomal signal peptidase 12 kDa subunit (SPC12); Region: SPC12; pfam06645
164756002155	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002156	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002157	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756002158	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756002159	Uncharacterized conserved protein [Function unknown]; Region: COG3391
164756002160	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
164756002161	Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056
164756002162	PIF1-like helicase; Region: PIF1; pfam05970
164756002163	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756002164	Walker A motif; other site
164756002165	ATP binding site [chemical binding]; other site
164756002166	Walker B motif; other site
164756002167	Family description; Region: UvrD_C_2; pfam13538
164756002168	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
164756002169	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
164756002170	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756002171	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
164756002172	P-loop containing region of AAA domain; Region: AAA_29; cl17516
164756002173	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
164756002174	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
164756002175	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
164756002176	Creatinine amidohydrolase; Region: Creatininase; pfam02633
164756002177	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
164756002178	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
164756002179	NAD binding site [chemical binding]; other site
164756002180	ligand binding site [chemical binding]; other site
164756002181	catalytic site [active]
164756002182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756002183	dimer interface [polypeptide binding]; other site
164756002184	conserved gate region; other site
164756002185	putative PBP binding loops; other site
164756002186	ABC-ATPase subunit interface; other site
164756002187	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
164756002188	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756002189	Walker A/P-loop; other site
164756002190	ATP binding site [chemical binding]; other site
164756002191	Q-loop/lid; other site
164756002192	ABC transporter signature motif; other site
164756002193	Walker B; other site
164756002194	D-loop; other site
164756002195	H-loop/switch region; other site
164756002196	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756002197	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
164756002198	substrate binding pocket [chemical binding]; other site
164756002199	membrane-bound complex binding site; other site
164756002200	hinge residues; other site
164756002201	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
164756002202	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756002203	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
164756002204	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
164756002205	AsnC family; Region: AsnC_trans_reg; pfam01037
164756002206	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
164756002207	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
164756002208	haloalkane dehalogenase; Provisional; Region: PRK03592
164756002209	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756002210	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002211	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002212	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002213	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002214	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756002215	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
164756002216	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
164756002217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756002218	NAD(P) binding site [chemical binding]; other site
164756002219	active site
164756002220	Uncharacterized conserved protein [Function unknown]; Region: COG1434
164756002221	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
164756002222	putative active site [active]
164756002223	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
164756002224	Uncharacterized conserved protein [Function unknown]; Region: COG2128
164756002225	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
164756002226	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
164756002227	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
164756002228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756002229	putative PBP binding loops; other site
164756002230	dimer interface [polypeptide binding]; other site
164756002231	ABC-ATPase subunit interface; other site
164756002232	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
164756002233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756002234	dimer interface [polypeptide binding]; other site
164756002235	conserved gate region; other site
164756002236	putative PBP binding loops; other site
164756002237	ABC-ATPase subunit interface; other site
164756002238	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
164756002239	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
164756002240	Walker A/P-loop; other site
164756002241	ATP binding site [chemical binding]; other site
164756002242	Q-loop/lid; other site
164756002243	ABC transporter signature motif; other site
164756002244	Walker B; other site
164756002245	D-loop; other site
164756002246	H-loop/switch region; other site
164756002247	TOBE domain; Region: TOBE_2; pfam08402
164756002248	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756002249	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
164756002250	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756002251	active site
164756002252	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
164756002253	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756002254	active site
164756002255	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
164756002256	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
164756002257	active site
164756002258	dimer interface [polypeptide binding]; other site
164756002259	non-prolyl cis peptide bond; other site
164756002260	insertion regions; other site
164756002261	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
164756002262	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
164756002263	active site
164756002264	non-prolyl cis peptide bond; other site
164756002265	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
164756002266	Sulfatase; Region: Sulfatase; cl17466
164756002267	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756002268	hydrophobic ligand binding site; other site
164756002269	helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422
164756002270	DNA binding residues [nucleotide binding]
164756002271	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756002272	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
164756002273	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
164756002274	Sulfate transporter family; Region: Sulfate_transp; pfam00916
164756002275	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
164756002276	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
164756002277	AAA domain; Region: AAA_30; pfam13604
164756002278	Family description; Region: UvrD_C_2; pfam13538
164756002279	LabA_like proteins; Region: LabA_like; cd06167
164756002280	putative metal binding site [ion binding]; other site
164756002281	Uncharacterized conserved protein [Function unknown]; Region: COG1432
164756002282	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
164756002283	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756002284	anti sigma factor interaction site; other site
164756002285	regulatory phosphorylation site [posttranslational modification]; other site
164756002286	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
164756002287	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
164756002288	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
164756002289	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
164756002290	HD domain; Region: HD_4; pfam13328
164756002291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756002292	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756002293	putative substrate translocation pore; other site
164756002294	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756002295	MarR family; Region: MarR_2; pfam12802
164756002296	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
164756002297	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756002298	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
164756002299	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
164756002300	oligomer interface [polypeptide binding]; other site
164756002301	metal binding site [ion binding]; metal-binding site
164756002302	metal binding site [ion binding]; metal-binding site
164756002303	putative Cl binding site [ion binding]; other site
164756002304	aspartate ring; other site
164756002305	basic sphincter; other site
164756002306	hydrophobic gate; other site
164756002307	periplasmic entrance; other site
164756002308	HD domain; Region: HD_5; pfam13487
164756002309	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
164756002310	Zn2+ binding site [ion binding]; other site
164756002311	Mg2+ binding site [ion binding]; other site
164756002312	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756002313	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756002314	DNA binding residues [nucleotide binding]
164756002315	dimerization interface [polypeptide binding]; other site
164756002316	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002317	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002318	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756002319	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756002320	substrate binding site [chemical binding]; other site
164756002321	oxyanion hole (OAH) forming residues; other site
164756002322	trimer interface [polypeptide binding]; other site
164756002323	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
164756002324	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
164756002325	Transcriptional regulator; Region: Rrf2; cl17282
164756002326	Predicted transcriptional regulator [Transcription]; Region: COG1959
164756002327	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
164756002328	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
164756002329	heme-binding site [chemical binding]; other site
164756002330	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
164756002331	FAD binding pocket [chemical binding]; other site
164756002332	FAD binding motif [chemical binding]; other site
164756002333	phosphate binding motif [ion binding]; other site
164756002334	beta-alpha-beta structure motif; other site
164756002335	NAD binding pocket [chemical binding]; other site
164756002336	Heme binding  pocket [chemical binding]; other site
164756002337	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
164756002338	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
164756002339	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
164756002340	active site
164756002341	catalytic site [active]
164756002342	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
164756002343	active site
164756002344	catalytic site [active]
164756002345	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
164756002346	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
164756002347	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
164756002348	putative homodimer interface [polypeptide binding]; other site
164756002349	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
164756002350	heterodimer interface [polypeptide binding]; other site
164756002351	homodimer interface [polypeptide binding]; other site
164756002352	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
164756002353	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
164756002354	23S rRNA interface [nucleotide binding]; other site
164756002355	L7/L12 interface [polypeptide binding]; other site
164756002356	putative thiostrepton binding site; other site
164756002357	L25 interface [polypeptide binding]; other site
164756002358	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
164756002359	mRNA/rRNA interface [nucleotide binding]; other site
164756002360	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322
164756002361	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
164756002362	putative catalytic site [active]
164756002363	putative metal binding site [ion binding]; other site
164756002364	putative phosphate binding site [ion binding]; other site
164756002365	Transposase; Region: HTH_Tnp_1; cl17663
164756002366	putative transposase OrfB; Reviewed; Region: PHA02517
164756002367	HTH-like domain; Region: HTH_21; pfam13276
164756002368	Integrase core domain; Region: rve; pfam00665
164756002369	Integrase core domain; Region: rve_3; cl15866
164756002370	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
164756002371	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
164756002372	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
164756002373	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
164756002374	Low molecular weight phosphatase family; Region: LMWPc; cl00105
164756002375	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
164756002376	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
164756002377	Integrase core domain; Region: rve; pfam00665
164756002378	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756002379	MULE transposase domain; Region: MULE; pfam10551
164756002380	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756002381	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
164756002382	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
164756002383	trimer interface [polypeptide binding]; other site
164756002384	active site
164756002385	substrate binding site [chemical binding]; other site
164756002386	CoA binding site [chemical binding]; other site
164756002387	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756002388	active site
164756002389	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
164756002390	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
164756002391	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
164756002392	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
164756002393	NADP binding site [chemical binding]; other site
164756002394	active site
164756002395	putative substrate binding site [chemical binding]; other site
164756002396	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
164756002397	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
164756002398	NADP-binding site; other site
164756002399	homotetramer interface [polypeptide binding]; other site
164756002400	substrate binding site [chemical binding]; other site
164756002401	homodimer interface [polypeptide binding]; other site
164756002402	active site
164756002403	Chain length determinant protein; Region: Wzz; cl15801
164756002404	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
164756002405	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
164756002406	PE-PPE domain; Region: PE-PPE; pfam08237
164756002407	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
164756002408	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756002409	S-adenosylmethionine binding site [chemical binding]; other site
164756002410	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
164756002411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756002412	S-adenosylmethionine binding site [chemical binding]; other site
164756002413	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756002414	TAP-like protein; Region: Abhydrolase_4; pfam08386
164756002415	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
164756002416	ABC1 family; Region: ABC1; pfam03109
164756002417	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
164756002418	active site
164756002419	ATP binding site [chemical binding]; other site
164756002420	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756002421	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
164756002422	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
164756002423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002424	Protein of unknown function (DUF664); Region: DUF664; pfam04978
164756002425	DinB superfamily; Region: DinB_2; pfam12867
164756002426	DinB superfamily; Region: DinB_2; pfam12867
164756002427	Predicted transcriptional regulator [Transcription]; Region: COG2378
164756002428	HTH domain; Region: HTH_11; pfam08279
164756002429	WYL domain; Region: WYL; pfam13280
164756002430	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
164756002431	putative catalytic site [active]
164756002432	putative metal binding site [ion binding]; other site
164756002433	putative phosphate binding site [ion binding]; other site
164756002434	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
164756002435	active site
164756002436	catalytic site [active]
164756002437	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
164756002438	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
164756002439	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
164756002440	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
164756002441	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
164756002442	nucleotide binding site [chemical binding]; other site
164756002443	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
164756002444	23S rRNA interface [nucleotide binding]; other site
164756002445	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
164756002446	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
164756002447	core dimer interface [polypeptide binding]; other site
164756002448	peripheral dimer interface [polypeptide binding]; other site
164756002449	L10 interface [polypeptide binding]; other site
164756002450	L11 interface [polypeptide binding]; other site
164756002451	putative EF-Tu interaction site [polypeptide binding]; other site
164756002452	putative EF-G interaction site [polypeptide binding]; other site
164756002453	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
164756002454	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
164756002455	Walker A/P-loop; other site
164756002456	ATP binding site [chemical binding]; other site
164756002457	Q-loop/lid; other site
164756002458	ABC transporter signature motif; other site
164756002459	Walker B; other site
164756002460	D-loop; other site
164756002461	H-loop/switch region; other site
164756002462	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
164756002463	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
164756002464	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
164756002465	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
164756002466	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
164756002467	RPB10 interaction site [polypeptide binding]; other site
164756002468	RPB1 interaction site [polypeptide binding]; other site
164756002469	RPB11 interaction site [polypeptide binding]; other site
164756002470	RPB3 interaction site [polypeptide binding]; other site
164756002471	RPB12 interaction site [polypeptide binding]; other site
164756002472	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
164756002473	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
164756002474	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
164756002475	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
164756002476	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
164756002477	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
164756002478	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
164756002479	G-loop; other site
164756002480	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
164756002481	DNA binding site [nucleotide binding]
164756002482	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
164756002483	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
164756002484	endonuclease IV; Provisional; Region: PRK01060
164756002485	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
164756002486	AP (apurinic/apyrimidinic) site pocket; other site
164756002487	DNA interaction; other site
164756002488	Metal-binding active site; metal-binding site
164756002489	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
164756002490	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
164756002491	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756002492	active site
164756002493	enoyl-CoA hydratase; Provisional; Region: PRK12478
164756002494	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756002495	substrate binding site [chemical binding]; other site
164756002496	oxyanion hole (OAH) forming residues; other site
164756002497	trimer interface [polypeptide binding]; other site
164756002498	PaaX-like protein; Region: PaaX; pfam07848
164756002499	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
164756002500	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756002501	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756002502	substrate binding site [chemical binding]; other site
164756002503	oxyanion hole (OAH) forming residues; other site
164756002504	trimer interface [polypeptide binding]; other site
164756002505	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
164756002506	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
164756002507	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
164756002508	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
164756002509	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002511	WHG domain; Region: WHG; pfam13305
164756002512	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
164756002513	S17 interaction site [polypeptide binding]; other site
164756002514	S8 interaction site; other site
164756002515	16S rRNA interaction site [nucleotide binding]; other site
164756002516	streptomycin interaction site [chemical binding]; other site
164756002517	23S rRNA interaction site [nucleotide binding]; other site
164756002518	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
164756002519	30S ribosomal protein S7; Validated; Region: PRK05302
164756002520	elongation factor G; Reviewed; Region: PRK00007
164756002521	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
164756002522	G1 box; other site
164756002523	putative GEF interaction site [polypeptide binding]; other site
164756002524	GTP/Mg2+ binding site [chemical binding]; other site
164756002525	Switch I region; other site
164756002526	G2 box; other site
164756002527	G3 box; other site
164756002528	Switch II region; other site
164756002529	G4 box; other site
164756002530	G5 box; other site
164756002531	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
164756002532	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
164756002533	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
164756002534	elongation factor Tu; Reviewed; Region: PRK00049
164756002535	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
164756002536	G1 box; other site
164756002537	GEF interaction site [polypeptide binding]; other site
164756002538	GTP/Mg2+ binding site [chemical binding]; other site
164756002539	Switch I region; other site
164756002540	G2 box; other site
164756002541	G3 box; other site
164756002542	Switch II region; other site
164756002543	G4 box; other site
164756002544	G5 box; other site
164756002545	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
164756002546	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
164756002547	Antibiotic Binding Site [chemical binding]; other site
164756002548	Cutinase; Region: Cutinase; pfam01083
164756002549	Short C-terminal domain; Region: SHOCT; pfam09851
164756002550	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002551	Ligand Binding Site [chemical binding]; other site
164756002552	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002553	Ligand Binding Site [chemical binding]; other site
164756002554	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756002555	classical (c) SDRs; Region: SDR_c; cd05233
164756002556	NAD(P) binding site [chemical binding]; other site
164756002557	active site
164756002558	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756002559	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
164756002560	inhibitor-cofactor binding pocket; inhibition site
164756002561	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756002562	catalytic residue [active]
164756002563	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
164756002564	Amidinotransferase; Region: Amidinotransf; pfam02274
164756002565	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
164756002566	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756002567	putative DNA binding site [nucleotide binding]; other site
164756002568	putative Zn2+ binding site [ion binding]; other site
164756002569	AsnC family; Region: AsnC_trans_reg; pfam01037
164756002570	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
164756002571	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756002572	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756002573	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
164756002574	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756002575	putative dimer interface [polypeptide binding]; other site
164756002576	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
164756002577	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
164756002578	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
164756002579	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756002580	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756002581	DNA binding residues [nucleotide binding]
164756002582	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
164756002583	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002584	mycofactocin precursor; Region: mycofactocin; TIGR03969
164756002585	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
164756002586	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
164756002587	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756002588	FeS/SAM binding site; other site
164756002589	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
164756002590	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
164756002591	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
164756002592	phosphate binding site [ion binding]; other site
164756002593	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
164756002594	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
164756002595	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756002596	active site
164756002597	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
164756002598	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
164756002599	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
164756002600	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
164756002601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756002602	putative substrate translocation pore; other site
164756002603	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002604	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002605	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756002606	Cytochrome P450; Region: p450; cl12078
164756002607	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756002608	Cytochrome P450; Region: p450; cl12078
164756002609	Carboxylesterase family; Region: COesterase; pfam00135
164756002610	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756002611	substrate binding pocket [chemical binding]; other site
164756002612	catalytic triad [active]
164756002613	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
164756002614	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
164756002615	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
164756002616	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
164756002617	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
164756002618	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
164756002619	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
164756002620	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
164756002621	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
164756002622	putative translocon binding site; other site
164756002623	protein-rRNA interface [nucleotide binding]; other site
164756002624	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
164756002625	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
164756002626	G-X-X-G motif; other site
164756002627	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
164756002628	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
164756002629	23S rRNA interface [nucleotide binding]; other site
164756002630	5S rRNA interface [nucleotide binding]; other site
164756002631	putative antibiotic binding site [chemical binding]; other site
164756002632	L25 interface [polypeptide binding]; other site
164756002633	L27 interface [polypeptide binding]; other site
164756002634	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
164756002635	putative translocon interaction site; other site
164756002636	23S rRNA interface [nucleotide binding]; other site
164756002637	signal recognition particle (SRP54) interaction site; other site
164756002638	L23 interface [polypeptide binding]; other site
164756002639	trigger factor interaction site; other site
164756002640	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
164756002641	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
164756002642	Sulfatase; Region: Sulfatase; pfam00884
164756002643	Uncharacterized conserved protein [Function unknown]; Region: COG1262
164756002644	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
164756002645	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
164756002646	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
164756002647	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
164756002648	RNA binding site [nucleotide binding]; other site
164756002649	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
164756002650	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
164756002651	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
164756002652	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
164756002653	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
164756002654	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
164756002655	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
164756002656	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
164756002657	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
164756002658	5S rRNA interface [nucleotide binding]; other site
164756002659	L27 interface [polypeptide binding]; other site
164756002660	23S rRNA interface [nucleotide binding]; other site
164756002661	L5 interface [polypeptide binding]; other site
164756002662	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
164756002663	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
164756002664	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
164756002665	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
164756002666	23S rRNA binding site [nucleotide binding]; other site
164756002667	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
164756002668	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756002669	MULE transposase domain; Region: MULE; pfam10551
164756002670	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
164756002671	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
164756002672	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
164756002673	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
164756002674	NADP binding site [chemical binding]; other site
164756002675	active site
164756002676	steroid binding site; other site
164756002677	Cupin; Region: Cupin_6; pfam12852
164756002678	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756002679	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756002680	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756002681	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756002682	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
164756002683	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756002684	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
164756002685	tandem repeat interface [polypeptide binding]; other site
164756002686	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
164756002687	oligomer interface [polypeptide binding]; other site
164756002688	active site residues [active]
164756002689	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
164756002690	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
164756002691	tandem repeat interface [polypeptide binding]; other site
164756002692	oligomer interface [polypeptide binding]; other site
164756002693	active site residues [active]
164756002694	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756002695	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
164756002696	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756002697	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
164756002698	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756002699	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
164756002700	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
164756002701	SecY translocase; Region: SecY; pfam00344
164756002702	adenylate kinase; Reviewed; Region: adk; PRK00279
164756002703	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
164756002704	AMP-binding site [chemical binding]; other site
164756002705	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
164756002706	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
164756002707	active site
164756002708	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
164756002709	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756002710	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756002711	DNA binding residues [nucleotide binding]
164756002712	Putative zinc-finger; Region: zf-HC2; pfam13490
164756002713	MarR family; Region: MarR; pfam01047
164756002714	Homeodomain-like domain; Region: HTH_23; cl17451
164756002715	Winged helix-turn helix; Region: HTH_29; pfam13551
164756002716	Integrase core domain; Region: rve; pfam00665
164756002717	Integrase core domain; Region: rve_3; pfam13683
164756002718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756002719	NmrA-like family; Region: NmrA; pfam05368
164756002720	NAD(P) binding site [chemical binding]; other site
164756002721	active site
164756002722	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756002723	MarR family; Region: MarR_2; pfam12802
164756002724	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
164756002725	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
164756002726	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
164756002727	Histidine kinase; Region: HisKA_3; pfam07730
164756002728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756002729	ATP binding site [chemical binding]; other site
164756002730	Mg2+ binding site [ion binding]; other site
164756002731	G-X-G motif; other site
164756002732	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756002733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756002734	active site
164756002735	phosphorylation site [posttranslational modification]
164756002736	intermolecular recognition site; other site
164756002737	dimerization interface [polypeptide binding]; other site
164756002738	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756002739	DNA binding residues [nucleotide binding]
164756002740	dimerization interface [polypeptide binding]; other site
164756002741	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
164756002742	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756002743	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756002744	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
164756002745	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
164756002746	malonyl-CoA binding site [chemical binding]; other site
164756002747	dimer interface [polypeptide binding]; other site
164756002748	active site
164756002749	product binding site; other site
164756002750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
164756002751	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
164756002752	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756002753	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756002754	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
164756002755	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756002756	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
164756002757	substrate binding pocket [chemical binding]; other site
164756002758	FAD binding site [chemical binding]; other site
164756002759	catalytic base [active]
164756002760	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
164756002761	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
164756002762	tetrameric interface [polypeptide binding]; other site
164756002763	NAD binding site [chemical binding]; other site
164756002764	catalytic residues [active]
164756002765	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
164756002766	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
164756002767	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
164756002768	NAD binding site [chemical binding]; other site
164756002769	substrate binding site [chemical binding]; other site
164756002770	homodimer interface [polypeptide binding]; other site
164756002771	active site
164756002772	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
164756002773	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
164756002774	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
164756002775	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
164756002776	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
164756002777	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
164756002778	ligand binding site [chemical binding]; other site
164756002779	flexible hinge region; other site
164756002780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756002781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756002782	ATP binding site [chemical binding]; other site
164756002783	Mg2+ binding site [ion binding]; other site
164756002784	G-X-G motif; other site
164756002785	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
164756002786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756002787	active site
164756002788	phosphorylation site [posttranslational modification]
164756002789	intermolecular recognition site; other site
164756002790	dimerization interface [polypeptide binding]; other site
164756002791	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
164756002792	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756002793	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756002794	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756002795	hydrophobic ligand binding site; other site
164756002796	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002797	Ligand Binding Site [chemical binding]; other site
164756002798	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002799	Ligand Binding Site [chemical binding]; other site
164756002800	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
164756002801	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756002802	catalytic Zn binding site [ion binding]; other site
164756002803	structural Zn binding site [ion binding]; other site
164756002804	NAD(P) binding site [chemical binding]; other site
164756002805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
164756002806	Predicted kinase [General function prediction only]; Region: COG0645
164756002807	AAA domain; Region: AAA_17; pfam13207
164756002808	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
164756002809	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756002810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756002811	active site
164756002812	phosphorylation site [posttranslational modification]
164756002813	intermolecular recognition site; other site
164756002814	dimerization interface [polypeptide binding]; other site
164756002815	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756002816	DNA binding residues [nucleotide binding]
164756002817	dimerization interface [polypeptide binding]; other site
164756002818	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
164756002819	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
164756002820	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
164756002821	Histidine kinase; Region: HisKA_3; pfam07730
164756002822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756002823	ATP binding site [chemical binding]; other site
164756002824	G-X-G motif; other site
164756002825	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
164756002826	FMN binding site [chemical binding]; other site
164756002827	dimer interface [polypeptide binding]; other site
164756002828	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
164756002829	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756002830	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756002831	active site
164756002832	Erythromycin esterase; Region: Erythro_esteras; pfam05139
164756002833	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
164756002834	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
164756002835	ATP cone domain; Region: ATP-cone; pfam03477
164756002836	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
164756002837	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
164756002838	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
164756002839	active site
164756002840	dimer interface [polypeptide binding]; other site
164756002841	effector binding site; other site
164756002842	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002843	Ligand Binding Site [chemical binding]; other site
164756002844	Domain of unknown function (DUF385); Region: DUF385; cl04387
164756002845	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
164756002846	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
164756002847	tetramer interface [polypeptide binding]; other site
164756002848	TPP-binding site [chemical binding]; other site
164756002849	heterodimer interface [polypeptide binding]; other site
164756002850	phosphorylation loop region [posttranslational modification]
164756002851	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
164756002852	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
164756002853	TPP binding site [chemical binding]; other site
164756002854	alpha subunit interface [polypeptide binding]; other site
164756002855	heterodimer interface [polypeptide binding]; other site
164756002856	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
164756002857	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
164756002858	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
164756002859	E3 interaction surface; other site
164756002860	lipoyl attachment site [posttranslational modification]; other site
164756002861	e3 binding domain; Region: E3_binding; pfam02817
164756002862	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
164756002863	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
164756002864	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
164756002865	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
164756002866	putative NAD(P) binding site [chemical binding]; other site
164756002867	putative substrate binding site [chemical binding]; other site
164756002868	catalytic Zn binding site [ion binding]; other site
164756002869	structural Zn binding site [ion binding]; other site
164756002870	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002871	Ligand Binding Site [chemical binding]; other site
164756002872	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002873	Ligand Binding Site [chemical binding]; other site
164756002874	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
164756002875	Domain of unknown function DUF21; Region: DUF21; pfam01595
164756002876	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
164756002877	Transporter associated domain; Region: CorC_HlyC; smart01091
164756002878	phosphoglycolate phosphatase; Provisional; Region: PRK01158
164756002879	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756002880	active site
164756002881	motif I; other site
164756002882	motif II; other site
164756002883	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
164756002884	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
164756002885	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756002886	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
164756002887	Soluble P-type ATPase [General function prediction only]; Region: COG4087
164756002888	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
164756002889	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002890	Ligand Binding Site [chemical binding]; other site
164756002891	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002892	Ligand Binding Site [chemical binding]; other site
164756002893	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
164756002894	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
164756002895	Divalent cation transporter; Region: MgtE; cl00786
164756002896	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002897	Ligand Binding Site [chemical binding]; other site
164756002898	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002899	Ligand Binding Site [chemical binding]; other site
164756002900	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756002901	Ligand Binding Site [chemical binding]; other site
164756002902	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
164756002903	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
164756002904	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
164756002905	dimer interface [polypeptide binding]; other site
164756002906	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
164756002907	rRNA binding site [nucleotide binding]; other site
164756002908	predicted 30S ribosome binding site; other site
164756002909	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
164756002910	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
164756002911	30S ribosomal protein S13; Region: bact_S13; TIGR03631
164756002912	30S ribosomal protein S11; Validated; Region: PRK05309
164756002913	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
164756002914	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
164756002915	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
164756002916	RNA binding surface [nucleotide binding]; other site
164756002917	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
164756002918	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
164756002919	alphaNTD homodimer interface [polypeptide binding]; other site
164756002920	alphaNTD - beta interaction site [polypeptide binding]; other site
164756002921	alphaNTD - beta' interaction site [polypeptide binding]; other site
164756002922	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
164756002923	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
164756002924	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
164756002925	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
164756002926	dimerization interface 3.5A [polypeptide binding]; other site
164756002927	active site
164756002928	Cutinase; Region: Cutinase; pfam01083
164756002929	Cutinase; Region: Cutinase; pfam01083
164756002930	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
164756002931	EamA-like transporter family; Region: EamA; pfam00892
164756002932	EamA-like transporter family; Region: EamA; pfam00892
164756002933	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
164756002934	CGNR zinc finger; Region: zf-CGNR; pfam11706
164756002935	Homeodomain-like domain; Region: HTH_23; cl17451
164756002936	Winged helix-turn helix; Region: HTH_29; pfam13551
164756002937	Integrase core domain; Region: rve; pfam00665
164756002938	Integrase core domain; Region: rve_3; pfam13683
164756002939	Transposase; Region: DEDD_Tnp_IS110; pfam01548
164756002940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
164756002941	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
164756002942	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756002943	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756002944	metal binding site [ion binding]; metal-binding site
164756002945	active site
164756002946	I-site; other site
164756002947	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
164756002948	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
164756002949	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
164756002950	active site
164756002951	catalytic residues [active]
164756002952	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
164756002953	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
164756002954	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756002955	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
164756002956	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756002957	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756002958	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
164756002959	Proteins of 100 residues with WXG; Region: WXG100; cl02005
164756002960	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
164756002961	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
164756002962	23S rRNA interface [nucleotide binding]; other site
164756002963	L3 interface [polypeptide binding]; other site
164756002964	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
164756002965	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
164756002966	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
164756002967	active site
164756002968	substrate binding site [chemical binding]; other site
164756002969	metal binding site [ion binding]; metal-binding site
164756002970	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
164756002971	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756002972	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
164756002973	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
164756002974	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
164756002975	glutaminase active site [active]
164756002976	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
164756002977	dimer interface [polypeptide binding]; other site
164756002978	active site
164756002979	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
164756002980	dimer interface [polypeptide binding]; other site
164756002981	active site
164756002982	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
164756002983	putative hydrophobic ligand binding site [chemical binding]; other site
164756002984	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756002985	putative DNA binding site [nucleotide binding]; other site
164756002986	dimerization interface [polypeptide binding]; other site
164756002987	putative Zn2+ binding site [ion binding]; other site
164756002988	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
164756002989	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
164756002990	Uncharacterized conserved protein [Function unknown]; Region: COG0062
164756002991	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
164756002992	putative substrate binding site [chemical binding]; other site
164756002993	putative ATP binding site [chemical binding]; other site
164756002994	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
164756002995	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
164756002996	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756002997	catalytic residue [active]
164756002998	alanine racemase; Reviewed; Region: alr; PRK00053
164756002999	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
164756003000	active site
164756003001	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
164756003002	dimer interface [polypeptide binding]; other site
164756003003	substrate binding site [chemical binding]; other site
164756003004	catalytic residues [active]
164756003005	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756003006	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756003007	TAP-like protein; Region: Abhydrolase_4; pfam08386
164756003008	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
164756003009	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
164756003010	Glycoprotease family; Region: Peptidase_M22; pfam00814
164756003011	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
164756003012	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756003013	Coenzyme A binding pocket [chemical binding]; other site
164756003014	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
164756003015	UGMP family protein; Validated; Region: PRK09604
164756003016	SnoaL-like domain; Region: SnoaL_4; pfam13577
164756003017	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
164756003018	oligomerisation interface [polypeptide binding]; other site
164756003019	mobile loop; other site
164756003020	roof hairpin; other site
164756003021	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
164756003022	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
164756003023	ring oligomerisation interface [polypeptide binding]; other site
164756003024	ATP/Mg binding site [chemical binding]; other site
164756003025	stacking interactions; other site
164756003026	hinge regions; other site
164756003027	MarR family; Region: MarR_2; cl17246
164756003028	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756003029	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
164756003030	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
164756003031	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
164756003032	Transcription factor WhiB; Region: Whib; pfam02467
164756003033	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
164756003034	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756003035	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756003036	DNA binding residues [nucleotide binding]
164756003037	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
164756003038	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
164756003039	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
164756003040	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
164756003041	active site
164756003042	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
164756003043	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
164756003044	phosphate binding site [ion binding]; other site
164756003045	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
164756003046	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
164756003047	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756003048	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
164756003049	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
164756003050	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
164756003051	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
164756003052	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
164756003053	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756003054	motif II; other site
164756003055	GMP synthase; Reviewed; Region: guaA; PRK00074
164756003056	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
164756003057	AMP/PPi binding site [chemical binding]; other site
164756003058	candidate oxyanion hole; other site
164756003059	catalytic triad [active]
164756003060	potential glutamine specificity residues [chemical binding]; other site
164756003061	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
164756003062	ATP Binding subdomain [chemical binding]; other site
164756003063	Ligand Binding sites [chemical binding]; other site
164756003064	Dimerization subdomain; other site
164756003065	DNA Polymerase Y-family; Region: PolY_like; cd03468
164756003066	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
164756003067	DNA binding site [nucleotide binding]
164756003068	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756003069	MarR family; Region: MarR; pfam01047
164756003070	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
164756003071	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
164756003072	active site
164756003073	MarR family; Region: MarR_2; pfam12802
164756003074	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756003075	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
164756003076	dimer interaction site [polypeptide binding]; other site
164756003077	substrate-binding tunnel; other site
164756003078	active site
164756003079	catalytic site [active]
164756003080	substrate binding site [chemical binding]; other site
164756003081	Universal stress protein family; Region: Usp; pfam00582
164756003082	Ligand Binding Site [chemical binding]; other site
164756003083	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756003084	Ligand Binding Site [chemical binding]; other site
164756003085	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
164756003086	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
164756003087	active site
164756003088	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
164756003089	generic binding surface II; other site
164756003090	generic binding surface I; other site
164756003091	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
164756003092	FMN binding site [chemical binding]; other site
164756003093	dimer interface [polypeptide binding]; other site
164756003094	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
164756003095	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
164756003096	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756003097	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756003098	active site
164756003099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756003100	S-adenosylmethionine binding site [chemical binding]; other site
164756003101	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756003102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756003103	ATP binding site [chemical binding]; other site
164756003104	Mg2+ binding site [ion binding]; other site
164756003105	G-X-G motif; other site
164756003106	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
164756003107	Protein of unknown function (DUF742); Region: DUF742; pfam05331
164756003108	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
164756003109	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
164756003110	G1 box; other site
164756003111	GTP/Mg2+ binding site [chemical binding]; other site
164756003112	G2 box; other site
164756003113	Switch I region; other site
164756003114	G3 box; other site
164756003115	Switch II region; other site
164756003116	G4 box; other site
164756003117	G5 box; other site
164756003118	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
164756003119	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
164756003120	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
164756003121	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
164756003122	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
164756003123	Transglutaminase/protease-like homologues; Region: TGc; smart00460
164756003124	PGAP1-like protein; Region: PGAP1; pfam07819
164756003125	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
164756003126	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
164756003127	phosphopeptide binding site; other site
164756003128	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
164756003129	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
164756003130	phosphopeptide binding site; other site
164756003131	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
164756003132	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
164756003133	Walker A/P-loop; other site
164756003134	ATP binding site [chemical binding]; other site
164756003135	Q-loop/lid; other site
164756003136	ABC transporter signature motif; other site
164756003137	Walker B; other site
164756003138	D-loop; other site
164756003139	H-loop/switch region; other site
164756003140	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
164756003141	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
164756003142	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
164756003143	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
164756003144	active site
164756003145	FMN binding site [chemical binding]; other site
164756003146	substrate binding site [chemical binding]; other site
164756003147	putative catalytic residue [active]
164756003148	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
164756003149	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
164756003150	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
164756003151	homodimer interface [polypeptide binding]; other site
164756003152	NADP binding site [chemical binding]; other site
164756003153	substrate binding site [chemical binding]; other site
164756003154	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
164756003155	Methyltransferase domain; Region: Methyltransf_23; pfam13489
164756003156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756003157	S-adenosylmethionine binding site [chemical binding]; other site
164756003158	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
164756003159	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
164756003160	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
164756003161	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
164756003162	homodimer interface [polypeptide binding]; other site
164756003163	substrate-cofactor binding pocket; other site
164756003164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756003165	catalytic residue [active]
164756003166	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
164756003167	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
164756003168	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756003169	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
164756003170	putative catalytic site [active]
164756003171	putative metal binding site [ion binding]; other site
164756003172	putative phosphate binding site [ion binding]; other site
164756003173	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
164756003174	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
164756003175	active site
164756003176	HIGH motif; other site
164756003177	dimer interface [polypeptide binding]; other site
164756003178	KMSKS motif; other site
164756003179	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
164756003180	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
164756003181	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
164756003182	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
164756003183	FMN binding site [chemical binding]; other site
164756003184	substrate binding site [chemical binding]; other site
164756003185	putative catalytic residue [active]
164756003186	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
164756003187	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
164756003188	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
164756003189	Strictosidine synthase; Region: Str_synth; pfam03088
164756003190	hypothetical protein; Provisional; Region: PRK06541
164756003191	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756003192	inhibitor-cofactor binding pocket; inhibition site
164756003193	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756003194	catalytic residue [active]
164756003195	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
164756003196	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
164756003197	putative DNA binding site [nucleotide binding]; other site
164756003198	putative Zn2+ binding site [ion binding]; other site
164756003199	AsnC family; Region: AsnC_trans_reg; pfam01037
164756003200	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
164756003201	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
164756003202	NAD(P) binding site [chemical binding]; other site
164756003203	catalytic residues [active]
164756003204	Acyltransferase family; Region: Acyl_transf_3; pfam01757
164756003205	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
164756003206	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756003207	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
164756003208	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
164756003209	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
164756003210	Domain of unknown function DUF20; Region: UPF0118; pfam01594
164756003211	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
164756003212	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
164756003213	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
164756003214	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
164756003215	L-aspartate oxidase; Provisional; Region: PRK06175
164756003216	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
164756003217	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
164756003218	putative Iron-sulfur protein interface [polypeptide binding]; other site
164756003219	putative proximal heme binding site [chemical binding]; other site
164756003220	putative SdhC-like subunit interface [polypeptide binding]; other site
164756003221	putative distal heme binding site [chemical binding]; other site
164756003222	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
164756003223	putative Iron-sulfur protein interface [polypeptide binding]; other site
164756003224	putative proximal heme binding site [chemical binding]; other site
164756003225	putative SdhD-like interface [polypeptide binding]; other site
164756003226	putative distal heme binding site [chemical binding]; other site
164756003227	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
164756003228	active site
164756003229	catalytic motif [active]
164756003230	Zn binding site [ion binding]; other site
164756003231	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
164756003232	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
164756003233	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
164756003234	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
164756003235	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
164756003236	adenosine deaminase; Provisional; Region: PRK09358
164756003237	active site
164756003238	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
164756003239	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
164756003240	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756003241	cyclase homology domain; Region: CHD; cd07302
164756003242	nucleotidyl binding site; other site
164756003243	metal binding site [ion binding]; metal-binding site
164756003244	dimer interface [polypeptide binding]; other site
164756003245	cyclase homology domain; Region: CHD; cd07302
164756003246	nucleotidyl binding site; other site
164756003247	metal binding site [ion binding]; metal-binding site
164756003248	dimer interface [polypeptide binding]; other site
164756003249	AAA ATPase domain; Region: AAA_16; pfam13191
164756003250	Double zinc ribbon; Region: DZR; pfam12773
164756003251	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
164756003252	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756003253	cyclase homology domain; Region: CHD; cd07302
164756003254	nucleotidyl binding site; other site
164756003255	metal binding site [ion binding]; metal-binding site
164756003256	dimer interface [polypeptide binding]; other site
164756003257	AAA ATPase domain; Region: AAA_16; pfam13191
164756003258	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
164756003259	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
164756003260	NlpC/P60 family; Region: NLPC_P60; pfam00877
164756003261	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756003262	active site
164756003263	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
164756003264	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
164756003265	active site
164756003266	substrate binding site [chemical binding]; other site
164756003267	metal binding site [ion binding]; metal-binding site
164756003268	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756003269	MarR family; Region: MarR_2; pfam12802
164756003270	Putative ammonia monooxygenase; Region: AmoA; pfam05145
164756003271	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
164756003272	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
164756003273	purine nucleoside phosphorylase; Provisional; Region: PRK08202
164756003274	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
164756003275	amidohydrolase; Region: amidohydrolases; TIGR01891
164756003276	metal binding site [ion binding]; metal-binding site
164756003277	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
164756003278	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
164756003279	metal binding site [ion binding]; metal-binding site
164756003280	putative dimer interface [polypeptide binding]; other site
164756003281	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
164756003282	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
164756003283	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
164756003284	putative active site pocket [active]
164756003285	dimerization interface [polypeptide binding]; other site
164756003286	putative catalytic residue [active]
164756003287	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
164756003288	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756003289	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756003290	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
164756003291	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
164756003292	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
164756003293	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
164756003294	active site
164756003295	short chain dehydrogenase; Provisional; Region: PRK07035
164756003296	classical (c) SDRs; Region: SDR_c; cd05233
164756003297	NAD(P) binding site [chemical binding]; other site
164756003298	active site
164756003299	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756003300	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756003301	substrate binding site [chemical binding]; other site
164756003302	oxyanion hole (OAH) forming residues; other site
164756003303	trimer interface [polypeptide binding]; other site
164756003304	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
164756003305	Winged helix-turn helix; Region: HTH_29; pfam13551
164756003306	Integrase core domain; Region: rve; pfam00665
164756003307	Integrase core domain; Region: rve_3; pfam13683
164756003308	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
164756003309	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756003310	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
164756003311	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
164756003312	FAD binding pocket [chemical binding]; other site
164756003313	FAD binding motif [chemical binding]; other site
164756003314	phosphate binding motif [ion binding]; other site
164756003315	beta-alpha-beta structure motif; other site
164756003316	NAD binding pocket [chemical binding]; other site
164756003317	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756003318	catalytic loop [active]
164756003319	iron binding site [ion binding]; other site
164756003320	Fatty acid desaturase; Region: FA_desaturase; pfam00487
164756003321	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
164756003322	putative di-iron ligands [ion binding]; other site
164756003323	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
164756003324	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
164756003325	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
164756003326	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
164756003327	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
164756003328	[4Fe-4S] binding site [ion binding]; other site
164756003329	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756003330	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756003331	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756003332	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
164756003333	molybdopterin cofactor binding site; other site
164756003334	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
164756003335	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756003336	putative substrate translocation pore; other site
164756003337	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
164756003338	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
164756003339	putative DNA binding site [nucleotide binding]; other site
164756003340	catalytic residue [active]
164756003341	putative H2TH interface [polypeptide binding]; other site
164756003342	putative catalytic residues [active]
164756003343	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
164756003344	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
164756003345	Protein of unknown function (DUF1269); Region: DUF1269; pfam06897
164756003346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756003347	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
164756003348	ATP binding site [chemical binding]; other site
164756003349	putative Mg++ binding site [ion binding]; other site
164756003350	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756003351	nucleotide binding region [chemical binding]; other site
164756003352	ATP-binding site [chemical binding]; other site
164756003353	DEAD/H associated; Region: DEAD_assoc; pfam08494
164756003354	hypothetical protein; Provisional; Region: PRK06194
164756003355	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756003356	NAD(P) binding site [chemical binding]; other site
164756003357	active site
164756003358	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
164756003359	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
164756003360	active site
164756003361	TDP-binding site; other site
164756003362	acceptor substrate-binding pocket; other site
164756003363	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
164756003364	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756003365	tetrameric interface [polypeptide binding]; other site
164756003366	NAD binding site [chemical binding]; other site
164756003367	catalytic residues [active]
164756003368	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
164756003369	AsnC family; Region: AsnC_trans_reg; pfam01037
164756003370	L-lysine aminotransferase; Provisional; Region: PRK08297
164756003371	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756003372	inhibitor-cofactor binding pocket; inhibition site
164756003373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756003374	catalytic residue [active]
164756003375	Restriction endonuclease; Region: Mrr_cat; pfam04471
164756003376	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756003377	short chain dehydrogenase; Provisional; Region: PRK06701
164756003378	NAD(P) binding site [chemical binding]; other site
164756003379	active site
164756003380	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
164756003381	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
164756003382	putative ADP-binding pocket [chemical binding]; other site
164756003383	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
164756003384	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
164756003385	active site
164756003386	DNA binding site [nucleotide binding]
164756003387	Int/Topo IB signature motif; other site
164756003388	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
164756003389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
164756003390	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
164756003391	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756003392	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
164756003393	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756003394	DNA binding residues [nucleotide binding]
164756003395	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756003396	anti sigma factor interaction site; other site
164756003397	regulatory phosphorylation site [posttranslational modification]; other site
164756003398	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
164756003399	Ligand binding site; other site
164756003400	metal-binding site
164756003401	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756003402	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756003403	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
164756003404	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
164756003405	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
164756003406	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
164756003407	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
164756003408	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
164756003409	carboxyltransferase (CT) interaction site; other site
164756003410	biotinylation site [posttranslational modification]; other site
164756003411	Fe-S metabolism associated domain; Region: SufE; cl00951
164756003412	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
164756003413	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
164756003414	active site residue [active]
164756003415	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
164756003416	active site residue [active]
164756003417	Maf-like protein; Region: Maf; pfam02545
164756003418	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
164756003419	active site
164756003420	dimer interface [polypeptide binding]; other site
164756003421	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
164756003422	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
164756003423	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
164756003424	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
164756003425	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
164756003426	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
164756003427	Bacterial sugar transferase; Region: Bac_transf; pfam02397
164756003428	Bacterial PH domain; Region: DUF304; pfam03703
164756003429	Predicted membrane protein [Function unknown]; Region: COG2246
164756003430	GtrA-like protein; Region: GtrA; pfam04138
164756003431	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
164756003432	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756003433	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
164756003434	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756003435	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
164756003436	FAD binding site [chemical binding]; other site
164756003437	homotetramer interface [polypeptide binding]; other site
164756003438	substrate binding pocket [chemical binding]; other site
164756003439	catalytic base [active]
164756003440	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
164756003441	Bacterial sugar transferase; Region: Bac_transf; pfam02397
164756003442	hypothetical protein; Provisional; Region: PRK07233
164756003443	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
164756003444	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756003445	active site
164756003446	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
164756003447	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
164756003448	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
164756003449	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756003450	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
164756003451	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
164756003452	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756003453	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
164756003454	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756003455	Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940
164756003456	putative active site [active]
164756003457	putative Zn binding site [ion binding]; other site
164756003458	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
164756003459	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
164756003460	active site
164756003461	homodimer interface [polypeptide binding]; other site
164756003462	TIGR03089 family protein; Region: TIGR03089
164756003463	Transcriptional regulator [Transcription]; Region: LytR; COG1316
164756003464	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
164756003465	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
164756003466	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
164756003467	NADP binding site [chemical binding]; other site
164756003468	active site
164756003469	putative substrate binding site [chemical binding]; other site
164756003470	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
164756003471	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
164756003472	Probable Catalytic site; other site
164756003473	metal-binding site
164756003474	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
164756003475	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
164756003476	active site
164756003477	Substrate binding site; other site
164756003478	Mg++ binding site; other site
164756003479	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
164756003480	putative trimer interface [polypeptide binding]; other site
164756003481	putative CoA binding site [chemical binding]; other site
164756003482	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
164756003483	nudix motif; other site
164756003484	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
164756003485	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
164756003486	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
164756003487	putative FMN binding site [chemical binding]; other site
164756003488	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
164756003489	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
164756003490	phosphate binding site [ion binding]; other site
164756003491	dimer interface [polypeptide binding]; other site
164756003492	Transcription factor WhiB; Region: Whib; pfam02467
164756003493	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
164756003494	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
164756003495	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
164756003496	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
164756003497	active site
164756003498	substrate binding site [chemical binding]; other site
164756003499	metal binding site [ion binding]; metal-binding site
164756003500	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
164756003501	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
164756003502	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
164756003503	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
164756003504	amino acid transporter; Region: 2A0306; TIGR00909
164756003505	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
164756003506	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
164756003507	Fatty acid desaturase; Region: FA_desaturase; pfam00487
164756003508	Di-iron ligands [ion binding]; other site
164756003509	Rubredoxin [Energy production and conversion]; Region: COG1773
164756003510	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
164756003511	iron binding site [ion binding]; other site
164756003512	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756003513	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756003514	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
164756003515	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
164756003516	homotetramer interface [polypeptide binding]; other site
164756003517	ligand binding site [chemical binding]; other site
164756003518	catalytic site [active]
164756003519	NAD binding site [chemical binding]; other site
164756003520	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
164756003521	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
164756003522	metal binding site [ion binding]; metal-binding site
164756003523	putative dimer interface [polypeptide binding]; other site
164756003524	Secretory lipase; Region: LIP; pfam03583
164756003525	ANTAR domain; Region: ANTAR; cl04297
164756003526	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
164756003527	TPR motif; other site
164756003528	binding surface
164756003529	TPR repeat; Region: TPR_11; pfam13414
164756003530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
164756003531	TPR motif; other site
164756003532	binding surface
164756003533	TPR repeat; Region: TPR_11; pfam13414
164756003534	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
164756003535	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
164756003536	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
164756003537	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
164756003538	TMP-binding site; other site
164756003539	ATP-binding site [chemical binding]; other site
164756003540	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756003541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756003542	active site
164756003543	phosphorylation site [posttranslational modification]
164756003544	intermolecular recognition site; other site
164756003545	dimerization interface [polypeptide binding]; other site
164756003546	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756003547	DNA binding site [nucleotide binding]
164756003548	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756003549	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756003550	dimerization interface [polypeptide binding]; other site
164756003551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756003552	dimer interface [polypeptide binding]; other site
164756003553	phosphorylation site [posttranslational modification]
164756003554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756003555	ATP binding site [chemical binding]; other site
164756003556	Mg2+ binding site [ion binding]; other site
164756003557	G-X-G motif; other site
164756003558	lipoprotein LpqB; Provisional; Region: PRK13616
164756003559	Sporulation and spore germination; Region: Germane; pfam10646
164756003560	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
164756003561	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
164756003562	comF family protein; Region: comF; TIGR00201
164756003563	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756003564	active site
164756003565	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
164756003566	30S subunit binding site; other site
164756003567	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
164756003568	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
164756003569	ATP binding site [chemical binding]; other site
164756003570	putative Mg++ binding site [ion binding]; other site
164756003571	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
164756003572	RNA12 protein; Region: RNA12; pfam10443
164756003573	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756003574	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756003575	BCCT family transporter; Region: BCCT; pfam02028
164756003576	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
164756003577	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
164756003578	FAD binding pocket [chemical binding]; other site
164756003579	FAD binding motif [chemical binding]; other site
164756003580	phosphate binding motif [ion binding]; other site
164756003581	beta-alpha-beta structure motif; other site
164756003582	NAD binding pocket [chemical binding]; other site
164756003583	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
164756003584	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756003585	catalytic loop [active]
164756003586	iron binding site [ion binding]; other site
164756003587	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
164756003588	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
164756003589	putative di-iron ligands [ion binding]; other site
164756003590	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
164756003591	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
164756003592	active site
164756003593	catalytic tetrad [active]
164756003594	Predicted GTPases [General function prediction only]; Region: COG1162
164756003595	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
164756003596	GTPase/Zn-binding domain interface [polypeptide binding]; other site
164756003597	GTP/Mg2+ binding site [chemical binding]; other site
164756003598	G4 box; other site
164756003599	G5 box; other site
164756003600	G1 box; other site
164756003601	Switch I region; other site
164756003602	G2 box; other site
164756003603	G3 box; other site
164756003604	Switch II region; other site
164756003605	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
164756003606	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
164756003607	hinge; other site
164756003608	active site
164756003609	Uncharacterized conserved protein [Function unknown]; Region: COG2135
164756003610	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
164756003611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756003612	S-adenosylmethionine binding site [chemical binding]; other site
164756003613	short chain dehydrogenase; Provisional; Region: PRK08278
164756003614	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
164756003615	NAD(P) binding site [chemical binding]; other site
164756003616	homodimer interface [polypeptide binding]; other site
164756003617	active site
164756003618	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
164756003619	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756003620	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
164756003621	dimerization interface [polypeptide binding]; other site
164756003622	substrate binding pocket [chemical binding]; other site
164756003623	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
164756003624	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
164756003625	TAP-like protein; Region: Abhydrolase_4; pfam08386
164756003626	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
164756003627	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
164756003628	AAA ATPase domain; Region: AAA_16; pfam13191
164756003629	AAA domain; Region: AAA_22; pfam13401
164756003630	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756003631	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756003632	DNA binding residues [nucleotide binding]
164756003633	dimerization interface [polypeptide binding]; other site
164756003634	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
164756003635	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756003636	catalytic loop [active]
164756003637	iron binding site [ion binding]; other site
164756003638	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
164756003639	FAD binding pocket [chemical binding]; other site
164756003640	FAD binding motif [chemical binding]; other site
164756003641	phosphate binding motif [ion binding]; other site
164756003642	beta-alpha-beta structure motif; other site
164756003643	NAD binding pocket [chemical binding]; other site
164756003644	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
164756003645	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
164756003646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756003647	NAD(P) binding site [chemical binding]; other site
164756003648	active site
164756003649	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756003650	inter-subunit interface; other site
164756003651	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
164756003652	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756003653	iron-sulfur cluster [ion binding]; other site
164756003654	[2Fe-2S] cluster binding site [ion binding]; other site
164756003655	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
164756003656	putative alpha subunit interface [polypeptide binding]; other site
164756003657	putative active site [active]
164756003658	putative substrate binding site [chemical binding]; other site
164756003659	Fe binding site [ion binding]; other site
164756003660	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
164756003661	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756003662	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
164756003663	dimerization interface [polypeptide binding]; other site
164756003664	substrate binding pocket [chemical binding]; other site
164756003665	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
164756003666	Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315
164756003667	active site
164756003668	catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
164756003669	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
164756003670	active site
164756003671	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
164756003672	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
164756003673	putative deacylase active site [active]
164756003674	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
164756003675	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756003676	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756003677	DNA binding residues [nucleotide binding]
164756003678	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
164756003679	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
164756003680	carboxyltransferase (CT) interaction site; other site
164756003681	biotinylation site [posttranslational modification]; other site
164756003682	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
164756003683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
164756003684	Histidine kinase; Region: HisKA_2; pfam07568
164756003685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756003686	ATP binding site [chemical binding]; other site
164756003687	Mg2+ binding site [ion binding]; other site
164756003688	G-X-G motif; other site
164756003689	Transcription factor WhiB; Region: Whib; pfam02467
164756003690	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
164756003691	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
164756003692	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
164756003693	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756003694	Coenzyme A binding pocket [chemical binding]; other site
164756003695	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
164756003696	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756003697	catalytic core [active]
164756003698	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
164756003699	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
164756003700	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
164756003701	Magnesium ion binding site [ion binding]; other site
164756003702	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
164756003703	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
164756003704	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
164756003705	putative NAD(P) binding site [chemical binding]; other site
164756003706	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
164756003707	DEAD-like helicases superfamily; Region: DEXDc; smart00487
164756003708	ATP binding site [chemical binding]; other site
164756003709	Mg++ binding site [ion binding]; other site
164756003710	motif III; other site
164756003711	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756003712	nucleotide binding region [chemical binding]; other site
164756003713	ATP-binding site [chemical binding]; other site
164756003714	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
164756003715	dinuclear metal binding motif [ion binding]; other site
164756003716	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
164756003717	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756003718	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756003719	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
164756003720	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
164756003721	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
164756003722	ATP binding site [chemical binding]; other site
164756003723	substrate interface [chemical binding]; other site
164756003724	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
164756003725	active site residue [active]
164756003726	TIGR02569 family protein; Region: TIGR02569_actnb
164756003727	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
164756003728	active site
164756003729	DNA binding site [nucleotide binding]
164756003730	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756003731	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756003732	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
164756003733	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
164756003734	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
164756003735	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
164756003736	Predicted membrane protein [Function unknown]; Region: COG4270
164756003737	Ion channel; Region: Ion_trans_2; pfam07885
164756003738	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
164756003739	TrkA-N domain; Region: TrkA_N; pfam02254
164756003740	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
164756003741	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
164756003742	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
164756003743	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
164756003744	putative NADH binding site [chemical binding]; other site
164756003745	putative active site [active]
164756003746	nudix motif; other site
164756003747	putative metal binding site [ion binding]; other site
164756003748	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
164756003749	catalytic residues [active]
164756003750	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
164756003751	Family description; Region: UvrD_C_2; pfam13538
164756003752	HRDC domain; Region: HRDC; pfam00570
164756003753	Transcription factor WhiB; Region: Whib; pfam02467
164756003754	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
164756003755	ABC1 family; Region: ABC1; pfam03109
164756003756	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
164756003757	active site
164756003758	ATP binding site [chemical binding]; other site
164756003759	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
164756003760	Uncharacterized conserved protein [Function unknown]; Region: COG5282
164756003761	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
164756003762	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
164756003763	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
164756003764	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
164756003765	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
164756003766	hypothetical protein; Validated; Region: PRK00068
164756003767	DNA binding site [nucleotide binding]
164756003768	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
164756003769	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
164756003770	Predicted ATPase [General function prediction only]; Region: COG3899
164756003771	AAA ATPase domain; Region: AAA_16; pfam13191
164756003772	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
164756003773	FAD binding domain; Region: FAD_binding_4; pfam01565
164756003774	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756003775	MULE transposase domain; Region: MULE; pfam10551
164756003776	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
164756003777	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
164756003778	Int/Topo IB signature motif; other site
164756003779	Helix-turn-helix domain; Region: HTH_36; pfam13730
164756003780	TrwC relaxase; Region: TrwC; pfam08751
164756003781	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
164756003782	AAA domain; Region: AAA_30; pfam13604
164756003783	Family description; Region: UvrD_C_2; pfam13538
164756003784	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
164756003785	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
164756003786	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756003787	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
164756003788	NlpC/P60 family; Region: NLPC_P60; pfam00877
164756003789	Domain of unknown function (DUF305); Region: DUF305; pfam03713
164756003790	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756003791	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756003792	dimerization interface [polypeptide binding]; other site
164756003793	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756003794	dimer interface [polypeptide binding]; other site
164756003795	phosphorylation site [posttranslational modification]
164756003796	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756003797	ATP binding site [chemical binding]; other site
164756003798	Mg2+ binding site [ion binding]; other site
164756003799	G-X-G motif; other site
164756003800	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756003801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756003802	active site
164756003803	phosphorylation site [posttranslational modification]
164756003804	intermolecular recognition site; other site
164756003805	dimerization interface [polypeptide binding]; other site
164756003806	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756003807	DNA binding site [nucleotide binding]
164756003808	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
164756003809	NlpC/P60 family; Region: NLPC_P60; pfam00877
164756003810	Penicillinase repressor; Region: Pencillinase_R; cl17580
164756003811	Peptidase family M48; Region: Peptidase_M48; cl12018
164756003812	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
164756003813	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
164756003814	dimer interface [polypeptide binding]; other site
164756003815	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756003816	catalytic residue [active]
164756003817	multidrug resistance protein MdtH; Provisional; Region: PRK11646
164756003818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756003819	putative substrate translocation pore; other site
164756003820	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756003821	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756003822	DNA binding site [nucleotide binding]
164756003823	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
164756003824	NlpC/P60 family; Region: NLPC_P60; pfam00877
164756003825	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
164756003826	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
164756003827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
164756003828	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
164756003829	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756003830	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
164756003831	metal-binding site [ion binding]
164756003832	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
164756003833	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
164756003834	metal-binding site [ion binding]
164756003835	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756003836	Soluble P-type ATPase [General function prediction only]; Region: COG4087
164756003837	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
164756003838	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
164756003839	putative homodimer interface [polypeptide binding]; other site
164756003840	putative homotetramer interface [polypeptide binding]; other site
164756003841	putative allosteric switch controlling residues; other site
164756003842	putative metal binding site [ion binding]; other site
164756003843	putative homodimer-homodimer interface [polypeptide binding]; other site
164756003844	HTH-like domain; Region: HTH_21; pfam13276
164756003845	Integrase core domain; Region: rve; pfam00665
164756003846	Integrase core domain; Region: rve_3; pfam13683
164756003847	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
164756003848	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
164756003849	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
164756003850	Walker A/P-loop; other site
164756003851	ATP binding site [chemical binding]; other site
164756003852	Q-loop/lid; other site
164756003853	ABC transporter signature motif; other site
164756003854	Walker B; other site
164756003855	D-loop; other site
164756003856	H-loop/switch region; other site
164756003857	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
164756003858	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756003859	Soluble P-type ATPase [General function prediction only]; Region: COG4087
164756003860	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
164756003861	Predicted membrane protein [Function unknown]; Region: COG3462
164756003862	Short C-terminal domain; Region: SHOCT; pfam09851
164756003863	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756003864	MULE transposase domain; Region: MULE; pfam10551
164756003865	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
164756003866	active site
164756003867	catalytic triad [active]
164756003868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756003869	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
164756003870	Walker A motif; other site
164756003871	ATP binding site [chemical binding]; other site
164756003872	Walker B motif; other site
164756003873	arginine finger; other site
164756003874	Thioredoxin; Region: Thioredoxin_4; pfam13462
164756003875	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
164756003876	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
164756003877	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756003878	Soluble P-type ATPase [General function prediction only]; Region: COG4087
164756003879	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
164756003880	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
164756003881	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
164756003882	TIR domain; Region: TIR_2; pfam13676
164756003883	Transcriptional regulator [Transcription]; Region: LysR; COG0583
164756003884	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756003885	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
164756003886	dimerization interface [polypeptide binding]; other site
164756003887	classical (c) SDRs; Region: SDR_c; cd05233
164756003888	NAD(P) binding site [chemical binding]; other site
164756003889	active site
164756003890	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756003891	MULE transposase domain; Region: MULE; pfam10551
164756003892	Protein of unknown function (DUF732); Region: DUF732; pfam05305
164756003893	DinB superfamily; Region: DinB_2; pfam12867
164756003894	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
164756003895	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
164756003896	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
164756003897	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756003898	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756003899	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756003900	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
164756003901	putative acyl-acceptor binding pocket; other site
164756003902	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
164756003903	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756003904	NAD(P) binding site [chemical binding]; other site
164756003905	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
164756003906	Transglycosylase; Region: Transgly; pfam00912
164756003907	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
164756003908	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
164756003909	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
164756003910	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
164756003911	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756003912	Cytochrome P450; Region: p450; cl12078
164756003913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756003914	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756003915	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
164756003916	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756003917	dimerization interface [polypeptide binding]; other site
164756003918	putative DNA binding site [nucleotide binding]; other site
164756003919	putative Zn2+ binding site [ion binding]; other site
164756003920	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
164756003921	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
164756003922	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756003923	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756003924	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
164756003925	Predicted membrane protein [Function unknown]; Region: COG2259
164756003926	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
164756003927	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
164756003928	G1 box; other site
164756003929	putative GEF interaction site [polypeptide binding]; other site
164756003930	GTP/Mg2+ binding site [chemical binding]; other site
164756003931	Switch I region; other site
164756003932	G2 box; other site
164756003933	G3 box; other site
164756003934	Switch II region; other site
164756003935	G4 box; other site
164756003936	G5 box; other site
164756003937	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
164756003938	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
164756003939	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
164756003940	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756003941	NAD(P) binding site [chemical binding]; other site
164756003942	active site
164756003943	enoyl-CoA hydratase; Provisional; Region: PRK08260
164756003944	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756003945	substrate binding site [chemical binding]; other site
164756003946	oxyanion hole (OAH) forming residues; other site
164756003947	trimer interface [polypeptide binding]; other site
164756003948	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
164756003949	acyl-CoA synthetase; Provisional; Region: PRK13391
164756003950	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756003951	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756003952	acyl-activating enzyme (AAE) consensus motif; other site
164756003953	putative AMP binding site [chemical binding]; other site
164756003954	putative active site [active]
164756003955	acyl-activating enzyme (AAE) consensus motif; other site
164756003956	putative CoA binding site [chemical binding]; other site
164756003957	CoA binding site [chemical binding]; other site
164756003958	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756003959	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756003960	active site
164756003961	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
164756003962	classical (c) SDRs; Region: SDR_c; cd05233
164756003963	NAD(P) binding site [chemical binding]; other site
164756003964	active site
164756003965	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
164756003966	Phosphotransferase enzyme family; Region: APH; pfam01636
164756003967	putative active site [active]
164756003968	putative substrate binding site [chemical binding]; other site
164756003969	ATP binding site [chemical binding]; other site
164756003970	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756003971	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756003972	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756003973	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756003974	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
164756003975	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
164756003976	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756003977	active site
164756003978	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
164756003979	putative transposase OrfB; Reviewed; Region: PHA02517
164756003980	HTH-like domain; Region: HTH_21; pfam13276
164756003981	Integrase core domain; Region: rve; pfam00665
164756003982	Integrase core domain; Region: rve_3; pfam13683
164756003983	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
164756003984	Winged helix-turn helix; Region: HTH_29; pfam13551
164756003985	Integrase core domain; Region: rve; pfam00665
164756003986	Integrase core domain; Region: rve_3; pfam13683
164756003987	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
164756003988	CoA binding domain; Region: CoA_binding_2; pfam13380
164756003989	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
164756003990	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
164756003991	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
164756003992	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756003993	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756003994	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756003995	active site
164756003996	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
164756003997	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756003998	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756003999	acyl-activating enzyme (AAE) consensus motif; other site
164756004000	putative AMP binding site [chemical binding]; other site
164756004001	putative active site [active]
164756004002	putative CoA binding site [chemical binding]; other site
164756004003	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
164756004004	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004005	substrate binding site [chemical binding]; other site
164756004006	oxyanion hole (OAH) forming residues; other site
164756004007	trimer interface [polypeptide binding]; other site
164756004008	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
164756004009	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
164756004010	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
164756004011	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756004012	dimer interface [polypeptide binding]; other site
164756004013	active site
164756004014	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756004015	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756004016	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
164756004017	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
164756004018	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756004019	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
164756004020	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
164756004021	FMN-binding pocket [chemical binding]; other site
164756004022	flavin binding motif; other site
164756004023	phosphate binding motif [ion binding]; other site
164756004024	beta-alpha-beta structure motif; other site
164756004025	NAD binding pocket [chemical binding]; other site
164756004026	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756004027	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
164756004028	catalytic loop [active]
164756004029	iron binding site [ion binding]; other site
164756004030	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756004031	Cytochrome P450; Region: p450; cl12078
164756004032	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756004033	Permease; Region: Permease; pfam02405
164756004034	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756004035	Permease; Region: Permease; pfam02405
164756004036	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004037	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756004038	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756004039	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004040	mce related protein; Region: MCE; pfam02470
164756004041	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004042	mce related protein; Region: MCE; pfam02470
164756004043	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004044	mce related protein; Region: MCE; pfam02470
164756004045	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004046	mce related protein; Region: MCE; pfam02470
164756004047	Protein of unknown function (DUF732); Region: DUF732; pfam05305
164756004048	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
164756004049	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
164756004050	classical (c) SDRs; Region: SDR_c; cd05233
164756004051	NAD(P) binding site [chemical binding]; other site
164756004052	active site
164756004053	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756004054	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756004055	substrate binding pocket [chemical binding]; other site
164756004056	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756004057	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
164756004058	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
164756004059	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004060	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004061	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004062	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004063	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
164756004064	active site
164756004065	catalytic site [active]
164756004066	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
164756004067	active site
164756004068	catalytic site [active]
164756004069	lipid-transfer protein; Provisional; Region: PRK08256
164756004070	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756004071	active site
164756004072	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756004073	classical (c) SDRs; Region: SDR_c; cd05233
164756004074	NAD(P) binding site [chemical binding]; other site
164756004075	active site
164756004076	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756004077	cyclase homology domain; Region: CHD; cd07302
164756004078	nucleotidyl binding site; other site
164756004079	metal binding site [ion binding]; metal-binding site
164756004080	dimer interface [polypeptide binding]; other site
164756004081	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756004082	hypothetical protein; Provisional; Region: PRK08244
164756004083	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
164756004084	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
164756004085	FAD binding site [chemical binding]; other site
164756004086	Methyltransferase domain; Region: Methyltransf_11; pfam08241
164756004087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756004088	Dynamin family; Region: Dynamin_N; pfam00350
164756004089	YfjP GTPase; Region: YfjP; cd11383
164756004090	G1 box; other site
164756004091	Walker A/P-loop; other site
164756004092	GTP/Mg2+ binding site [chemical binding]; other site
164756004093	ATP binding site [chemical binding]; other site
164756004094	Switch I region; other site
164756004095	G2 box; other site
164756004096	Switch II region; other site
164756004097	G3 box; other site
164756004098	G4 box; other site
164756004099	G5 box; other site
164756004100	Dynamin family; Region: Dynamin_N; pfam00350
164756004101	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
164756004102	G1 box; other site
164756004103	GTP/Mg2+ binding site [chemical binding]; other site
164756004104	G2 box; other site
164756004105	Switch I region; other site
164756004106	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
164756004107	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004108	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004109	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
164756004110	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004111	NAD(P) binding site [chemical binding]; other site
164756004112	active site
164756004113	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
164756004114	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
164756004115	NAD(P) binding site [chemical binding]; other site
164756004116	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756004117	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756004118	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
164756004119	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756004120	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
164756004121	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
164756004122	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756004123	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756004124	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756004125	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
164756004126	putative active site [active]
164756004127	putative substrate binding site [chemical binding]; other site
164756004128	ATP binding site [chemical binding]; other site
164756004129	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004130	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004131	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
164756004132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756004133	Walker A/P-loop; other site
164756004134	ATP binding site [chemical binding]; other site
164756004135	Q-loop/lid; other site
164756004136	ABC transporter signature motif; other site
164756004137	Walker B; other site
164756004138	D-loop; other site
164756004139	H-loop/switch region; other site
164756004140	enoyl-CoA hydratase; Provisional; Region: PRK06190
164756004141	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004142	substrate binding site [chemical binding]; other site
164756004143	oxyanion hole (OAH) forming residues; other site
164756004144	trimer interface [polypeptide binding]; other site
164756004145	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
164756004146	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
164756004147	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
164756004148	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
164756004149	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
164756004150	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
164756004151	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
164756004152	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
164756004153	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
164756004154	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
164756004155	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
164756004156	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
164756004157	Binuclear center (active site) [active]
164756004158	K-pathway; other site
164756004159	Putative proton exit pathway; other site
164756004160	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
164756004161	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
164756004162	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
164756004163	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
164756004164	4Fe-4S binding domain; Region: Fer4; pfam00037
164756004165	4Fe-4S binding domain; Region: Fer4; pfam00037
164756004166	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
164756004167	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
164756004168	NADH dehydrogenase subunit G; Validated; Region: PRK07860
164756004169	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756004170	catalytic loop [active]
164756004171	iron binding site [ion binding]; other site
164756004172	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
164756004173	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756004174	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756004175	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
164756004176	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
164756004177	SLBB domain; Region: SLBB; pfam10531
164756004178	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
164756004179	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
164756004180	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
164756004181	putative dimer interface [polypeptide binding]; other site
164756004182	[2Fe-2S] cluster binding site [ion binding]; other site
164756004183	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
164756004184	NADH dehydrogenase subunit D; Validated; Region: PRK06075
164756004185	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
164756004186	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
164756004187	NADH dehydrogenase subunit B; Validated; Region: PRK06411
164756004188	NADH dehydrogenase subunit A; Validated; Region: PRK07928
164756004189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
164756004190	active site
164756004191	phosphorylation site [posttranslational modification]
164756004192	intermolecular recognition site; other site
164756004193	dimerization interface [polypeptide binding]; other site
164756004194	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756004195	Methyltransferase domain; Region: Methyltransf_25; pfam13649
164756004196	S-adenosylmethionine binding site [chemical binding]; other site
164756004197	Phosphotransferase enzyme family; Region: APH; pfam01636
164756004198	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
164756004199	putative active site [active]
164756004200	putative substrate binding site [chemical binding]; other site
164756004201	ATP binding site [chemical binding]; other site
164756004202	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756004203	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756004204	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756004205	active site
164756004206	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004207	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004208	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
164756004209	active site
164756004210	catalytic residues [active]
164756004211	metal binding site [ion binding]; metal-binding site
164756004212	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756004213	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756004214	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756004215	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756004216	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
164756004217	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756004218	hydrophobic ligand binding site; other site
164756004219	Domain of unknown function (DUF385); Region: DUF385; pfam04075
164756004220	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756004221	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756004222	active site
164756004223	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004224	Putative esterase; Region: Esterase; pfam00756
164756004225	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
164756004226	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
164756004227	NADP binding site [chemical binding]; other site
164756004228	dimer interface [polypeptide binding]; other site
164756004229	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
164756004230	RibD C-terminal domain; Region: RibD_C; cl17279
164756004231	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
164756004232	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
164756004233	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
164756004234	Protein of unknown function (DUF461); Region: DUF461; pfam04314
164756004235	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
164756004236	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756004237	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756004238	active site
164756004239	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756004240	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756004241	active site
164756004242	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
164756004243	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
164756004244	active site
164756004245	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756004246	ferredoxin-NADP+ reductase; Region: PLN02852
164756004247	peptide chain release factor 2; Validated; Region: prfB; PRK00578
164756004248	This domain is found in peptide chain release factors; Region: PCRF; smart00937
164756004249	RF-1 domain; Region: RF-1; pfam00472
164756004250	Mechanosensitive ion channel; Region: MS_channel; pfam00924
164756004251	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
164756004252	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
164756004253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756004254	Walker A/P-loop; other site
164756004255	ATP binding site [chemical binding]; other site
164756004256	Q-loop/lid; other site
164756004257	ABC transporter signature motif; other site
164756004258	Walker B; other site
164756004259	D-loop; other site
164756004260	H-loop/switch region; other site
164756004261	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
164756004262	FtsX-like permease family; Region: FtsX; pfam02687
164756004263	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
164756004264	SmpB-tmRNA interface; other site
164756004265	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756004266	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756004267	metal binding site [ion binding]; metal-binding site
164756004268	active site
164756004269	I-site; other site
164756004270	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
164756004271	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
164756004272	PAS fold; Region: PAS_3; pfam08447
164756004273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756004274	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756004275	active site
164756004276	phosphorylation site [posttranslational modification]
164756004277	intermolecular recognition site; other site
164756004278	dimerization interface [polypeptide binding]; other site
164756004279	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756004280	DNA binding residues [nucleotide binding]
164756004281	dimerization interface [polypeptide binding]; other site
164756004282	Transcriptional regulator [Transcription]; Region: IclR; COG1414
164756004283	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
164756004284	Bacterial transcriptional regulator; Region: IclR; pfam01614
164756004285	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756004286	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756004287	iron-sulfur cluster [ion binding]; other site
164756004288	[2Fe-2S] cluster binding site [ion binding]; other site
164756004289	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756004290	beta subunit interface [polypeptide binding]; other site
164756004291	alpha subunit interface [polypeptide binding]; other site
164756004292	active site
164756004293	substrate binding site [chemical binding]; other site
164756004294	Fe binding site [ion binding]; other site
164756004295	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756004296	inter-subunit interface; other site
164756004297	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
164756004298	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004299	NAD(P) binding site [chemical binding]; other site
164756004300	active site
164756004301	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
164756004302	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756004303	HTH-like domain; Region: HTH_21; pfam13276
164756004304	Integrase core domain; Region: rve; pfam00665
164756004305	Integrase core domain; Region: rve_3; pfam13683
164756004306	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
164756004307	Transposase; Region: HTH_Tnp_1; pfam01527
164756004308	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
164756004309	Cupin domain; Region: Cupin_2; pfam07883
164756004310	Cupin domain; Region: Cupin_2; pfam07883
164756004311	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
164756004312	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
164756004313	putative active site [active]
164756004314	catalytic residue [active]
164756004315	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
164756004316	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
164756004317	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
164756004318	active site
164756004319	Fe binding site [ion binding]; other site
164756004320	SCP-2 sterol transfer family; Region: SCP2; pfam02036
164756004321	Class I aldolases; Region: Aldolase_Class_I; cl17187
164756004322	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
164756004323	catalytic residue [active]
164756004324	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756004325	inter-subunit interface; other site
164756004326	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
164756004327	L-aspartate oxidase; Provisional; Region: PRK06175
164756004328	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
164756004329	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
164756004330	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
164756004331	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756004332	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
164756004333	NAD(P) binding site [chemical binding]; other site
164756004334	catalytic residues [active]
164756004335	Integrase core domain; Region: rve; pfam00665
164756004336	Integrase core domain; Region: rve_3; pfam13683
164756004337	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756004338	inter-subunit interface; other site
164756004339	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756004340	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
164756004341	alpha subunit interaction site [polypeptide binding]; other site
164756004342	beta subunit interaction site [polypeptide binding]; other site
164756004343	iron-sulfur cluster [ion binding]; other site
164756004344	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756004345	beta subunit interface [polypeptide binding]; other site
164756004346	alpha subunit interface [polypeptide binding]; other site
164756004347	active site
164756004348	substrate binding site [chemical binding]; other site
164756004349	Fe binding site [ion binding]; other site
164756004350	short chain dehydrogenase; Provisional; Region: PRK06138
164756004351	classical (c) SDRs; Region: SDR_c; cd05233
164756004352	NAD(P) binding site [chemical binding]; other site
164756004353	active site
164756004354	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756004355	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
164756004356	putative NAD(P) binding site [chemical binding]; other site
164756004357	catalytic Zn binding site [ion binding]; other site
164756004358	VPS10 domain; Region: VPS10; smart00602
164756004359	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756004360	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
164756004361	[2Fe-2S] cluster binding site [ion binding]; other site
164756004362	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756004363	hydrophobic ligand binding site; other site
164756004364	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
164756004365	SCP-2 sterol transfer family; Region: SCP2; pfam02036
164756004366	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
164756004367	active site
164756004368	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756004369	Permease; Region: Permease; pfam02405
164756004370	Permease; Region: Permease; pfam02405
164756004371	Homeodomain-like domain; Region: HTH_23; cl17451
164756004372	Winged helix-turn helix; Region: HTH_29; pfam13551
164756004373	Integrase core domain; Region: rve; pfam00665
164756004374	Integrase core domain; Region: rve_3; pfam13683
164756004375	Permease; Region: Permease; pfam02405
164756004376	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004377	mce related protein; Region: MCE; pfam02470
164756004378	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756004379	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004380	mce related protein; Region: MCE; pfam02470
164756004381	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756004382	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004383	mce related protein; Region: MCE; pfam02470
164756004384	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004385	mce related protein; Region: MCE; pfam02470
164756004386	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756004387	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004388	mce related protein; Region: MCE; pfam02470
164756004389	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756004390	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756004391	mce related protein; Region: MCE; pfam02470
164756004392	Epoxide hydrolase N terminus; Region: EHN; pfam06441
164756004393	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756004394	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756004395	Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107
164756004396	NAD(P) binding site [chemical binding]; other site
164756004397	catalytic residues [active]
164756004398	catalytic residues [active]
164756004399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756004400	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756004401	putative substrate translocation pore; other site
164756004402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
164756004403	MarR family; Region: MarR; pfam01047
164756004404	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756004405	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
164756004406	alpha subunit interaction site [polypeptide binding]; other site
164756004407	beta subunit interaction site [polypeptide binding]; other site
164756004408	iron-sulfur cluster [ion binding]; other site
164756004409	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756004410	beta subunit interface [polypeptide binding]; other site
164756004411	alpha subunit interface [polypeptide binding]; other site
164756004412	active site
164756004413	substrate binding site [chemical binding]; other site
164756004414	Fe binding site [ion binding]; other site
164756004415	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756004416	inter-subunit interface; other site
164756004417	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756004418	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
164756004419	putative NAD(P) binding site [chemical binding]; other site
164756004420	catalytic Zn binding site [ion binding]; other site
164756004421	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756004422	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756004423	lipid-transfer protein; Provisional; Region: PRK07855
164756004424	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756004425	active site
164756004426	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
164756004427	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756004428	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756004429	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
164756004430	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756004431	iron-sulfur cluster [ion binding]; other site
164756004432	[2Fe-2S] cluster binding site [ion binding]; other site
164756004433	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756004434	beta subunit interface [polypeptide binding]; other site
164756004435	alpha subunit interface [polypeptide binding]; other site
164756004436	active site
164756004437	substrate binding site [chemical binding]; other site
164756004438	Fe binding site [ion binding]; other site
164756004439	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756004440	inter-subunit interface; other site
164756004441	Cupin domain; Region: Cupin_2; pfam07883
164756004442	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
164756004443	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756004444	MarR family; Region: MarR; pfam01047
164756004445	MarR family; Region: MarR_2; cl17246
164756004446	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756004447	MULE transposase domain; Region: MULE; pfam10551
164756004448	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756004449	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756004450	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756004451	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756004452	iron-sulfur cluster [ion binding]; other site
164756004453	[2Fe-2S] cluster binding site [ion binding]; other site
164756004454	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756004455	beta subunit interface [polypeptide binding]; other site
164756004456	alpha subunit interface [polypeptide binding]; other site
164756004457	active site
164756004458	substrate binding site [chemical binding]; other site
164756004459	Fe binding site [ion binding]; other site
164756004460	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756004461	inter-subunit interface; other site
164756004462	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
164756004463	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
164756004464	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
164756004465	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
164756004466	active site
164756004467	metal binding site [ion binding]; metal-binding site
164756004468	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
164756004469	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
164756004470	intersubunit interface [polypeptide binding]; other site
164756004471	active site
164756004472	Zn2+ binding site [ion binding]; other site
164756004473	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
164756004474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004475	NAD(P) binding site [chemical binding]; other site
164756004476	active site
164756004477	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
164756004478	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
164756004479	active site
164756004480	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756004481	MULE transposase domain; Region: MULE; pfam10551
164756004482	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
164756004483	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756004484	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
164756004485	alpha subunit interaction site [polypeptide binding]; other site
164756004486	beta subunit interaction site [polypeptide binding]; other site
164756004487	iron-sulfur cluster [ion binding]; other site
164756004488	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756004489	beta subunit interface [polypeptide binding]; other site
164756004490	alpha subunit interface [polypeptide binding]; other site
164756004491	active site
164756004492	substrate binding site [chemical binding]; other site
164756004493	Fe binding site [ion binding]; other site
164756004494	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756004495	inter-subunit interface; other site
164756004496	HTH-like domain; Region: HTH_21; pfam13276
164756004497	Integrase core domain; Region: rve; pfam00665
164756004498	Integrase core domain; Region: rve_3; pfam13683
164756004499	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756004500	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756004501	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
164756004502	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
164756004503	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
164756004504	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
164756004505	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
164756004506	active site
164756004507	inhibitor site; inhibition site
164756004508	dimer interface [polypeptide binding]; other site
164756004509	catalytic residue [active]
164756004510	Bacterial transcriptional regulator; Region: IclR; pfam01614
164756004511	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
164756004512	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
164756004513	active site
164756004514	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
164756004515	active site
164756004516	3-carboxy-cis,cis-muconate cycloisomerase; Region: protocat_pcaB; TIGR02426
164756004517	Lyase; Region: Lyase_1; pfam00206
164756004518	tetramer interface [polypeptide binding]; other site
164756004519	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756004520	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
164756004521	Coenzyme A transferase; Region: CoA_trans; cl17247
164756004522	Coenzyme A transferase; Region: CoA_trans; cl17247
164756004523	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
164756004524	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
164756004525	Cupin domain; Region: Cupin_2; pfam07883
164756004526	Protein of unknown function (DUF732); Region: DUF732; pfam05305
164756004527	HTH-like domain; Region: HTH_21; pfam13276
164756004528	Integrase core domain; Region: rve; pfam00665
164756004529	Integrase core domain; Region: rve_3; pfam13683
164756004530	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
164756004531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004532	NAD(P) binding site [chemical binding]; other site
164756004533	active site
164756004534	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
164756004535	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
164756004536	putative active site [active]
164756004537	catalytic triad [active]
164756004538	putative dimer interface [polypeptide binding]; other site
164756004539	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
164756004540	Domain of unknown function (DUF348); Region: DUF348; pfam03990
164756004541	Domain of unknown function (DUF348); Region: DUF348; pfam03990
164756004542	Domain of unknown function (DUF348); Region: DUF348; pfam03990
164756004543	G5 domain; Region: G5; pfam07501
164756004544	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
164756004545	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
164756004546	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
164756004547	putative NAD(P) binding site [chemical binding]; other site
164756004548	catalytic Zn binding site [ion binding]; other site
164756004549	structural Zn binding site [ion binding]; other site
164756004550	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
164756004551	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756004552	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756004553	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
164756004554	Cytochrome P450; Region: p450; cl12078
164756004555	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756004556	PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939
164756004557	putative deacylase active site [active]
164756004558	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
164756004559	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
164756004560	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756004561	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756004562	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756004563	active site
164756004564	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
164756004565	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756004566	acyl-activating enzyme (AAE) consensus motif; other site
164756004567	AMP binding site [chemical binding]; other site
164756004568	active site
164756004569	CoA binding site [chemical binding]; other site
164756004570	acyl carrier protein; Validated; Region: PRK05883
164756004571	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
164756004572	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
164756004573	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
164756004574	camphor resistance protein CrcB; Provisional; Region: PRK14228
164756004575	camphor resistance protein CrcB; Provisional; Region: PRK14216
164756004576	phosphoglucomutase; Validated; Region: PRK07564
164756004577	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
164756004578	active site
164756004579	substrate binding site [chemical binding]; other site
164756004580	metal binding site [ion binding]; metal-binding site
164756004581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756004582	putative substrate translocation pore; other site
164756004583	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756004584	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756004585	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756004586	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756004587	active site
164756004588	Winged helix-turn helix; Region: HTH_29; pfam13551
164756004589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
164756004590	Integrase core domain; Region: rve; pfam00665
164756004591	Integrase core domain; Region: rve_3; pfam13683
164756004592	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
164756004593	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
164756004594	PE-PPE domain; Region: PE-PPE; pfam08237
164756004595	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756004596	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756004597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756004598	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756004599	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
164756004600	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
164756004601	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756004602	ABC transporter signature motif; other site
164756004603	Walker B; other site
164756004604	D-loop; other site
164756004605	H-loop/switch region; other site
164756004606	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
164756004607	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756004608	Walker A/P-loop; other site
164756004609	ATP binding site [chemical binding]; other site
164756004610	Q-loop/lid; other site
164756004611	ABC transporter signature motif; other site
164756004612	Walker B; other site
164756004613	D-loop; other site
164756004614	H-loop/switch region; other site
164756004615	Conserved TM helix; Region: TM_helix; pfam05552
164756004616	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
164756004617	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
164756004618	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
164756004619	active site
164756004620	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
164756004621	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756004622	active site
164756004623	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
164756004624	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756004625	active site
164756004626	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
164756004627	PAS domain; Region: PAS_9; pfam13426
164756004628	putative active site [active]
164756004629	heme pocket [chemical binding]; other site
164756004630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004633	putative succinate dehydrogenase; Reviewed; Region: PRK12842
164756004634	GAF domain; Region: GAF; cl17456
164756004635	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756004636	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756004637	metal binding site [ion binding]; metal-binding site
164756004638	active site
164756004639	I-site; other site
164756004640	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
164756004641	hypothetical protein; Provisional; Region: PRK07877
164756004642	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
164756004643	ATP binding site [chemical binding]; other site
164756004644	substrate interface [chemical binding]; other site
164756004645	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
164756004646	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
164756004647	putative active site [active]
164756004648	putative catalytic site [active]
164756004649	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
164756004650	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756004651	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004652	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004653	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756004654	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756004655	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756004656	classical (c) SDRs; Region: SDR_c; cd05233
164756004657	NAD(P) binding site [chemical binding]; other site
164756004658	active site
164756004659	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756004660	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756004661	active site
164756004662	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756004663	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004664	NAD(P) binding site [chemical binding]; other site
164756004665	active site
164756004666	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
164756004667	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756004668	dimer interface [polypeptide binding]; other site
164756004669	active site
164756004670	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756004671	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756004672	active site
164756004673	Transcriptional regulators [Transcription]; Region: GntR; COG1802
164756004674	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756004675	DNA-binding site [nucleotide binding]; DNA binding site
164756004676	FCD domain; Region: FCD; pfam07729
164756004677	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
164756004678	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756004679	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756004680	acyl-activating enzyme (AAE) consensus motif; other site
164756004681	acyl-activating enzyme (AAE) consensus motif; other site
164756004682	AMP binding site [chemical binding]; other site
164756004683	active site
164756004684	CoA binding site [chemical binding]; other site
164756004685	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
164756004686	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756004687	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756004688	acyl-activating enzyme (AAE) consensus motif; other site
164756004689	AMP binding site [chemical binding]; other site
164756004690	active site
164756004691	CoA binding site [chemical binding]; other site
164756004692	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
164756004693	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756004694	AMP binding site [chemical binding]; other site
164756004695	active site
164756004696	acyl-activating enzyme (AAE) consensus motif; other site
164756004697	CoA binding site [chemical binding]; other site
164756004698	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756004699	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004700	substrate binding site [chemical binding]; other site
164756004701	oxyanion hole (OAH) forming residues; other site
164756004702	trimer interface [polypeptide binding]; other site
164756004703	enoyl-CoA hydratase; Provisional; Region: PRK06494
164756004704	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004705	substrate binding site [chemical binding]; other site
164756004706	oxyanion hole (OAH) forming residues; other site
164756004707	trimer interface [polypeptide binding]; other site
164756004708	enoyl-CoA hydratase; Provisional; Region: PRK06688
164756004709	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004710	substrate binding site [chemical binding]; other site
164756004711	oxyanion hole (OAH) forming residues; other site
164756004712	trimer interface [polypeptide binding]; other site
164756004713	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004714	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
164756004715	substrate binding site [chemical binding]; other site
164756004716	oxyanion hole (OAH) forming residues; other site
164756004717	trimer interface [polypeptide binding]; other site
164756004718	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756004719	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
164756004720	dimer interface [polypeptide binding]; other site
164756004721	active site
164756004722	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004723	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
164756004724	enoyl-CoA hydratase; Provisional; Region: PRK08252
164756004725	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004726	substrate binding site [chemical binding]; other site
164756004727	oxyanion hole (OAH) forming residues; other site
164756004728	trimer interface [polypeptide binding]; other site
164756004729	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756004730	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004731	NAD(P) binding site [chemical binding]; other site
164756004732	active site
164756004733	enoyl-CoA hydratase; Provisional; Region: PRK06210
164756004734	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004735	substrate binding site [chemical binding]; other site
164756004736	oxyanion hole (OAH) forming residues; other site
164756004737	trimer interface [polypeptide binding]; other site
164756004738	Amidohydrolase; Region: Amidohydro_2; pfam04909
164756004739	acyl-CoA synthetase; Validated; Region: PRK07798
164756004740	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756004741	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
164756004742	acyl-activating enzyme (AAE) consensus motif; other site
164756004743	acyl-activating enzyme (AAE) consensus motif; other site
164756004744	putative AMP binding site [chemical binding]; other site
164756004745	putative active site [active]
164756004746	putative CoA binding site [chemical binding]; other site
164756004747	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
164756004748	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756004749	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756004750	active site
164756004751	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756004752	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756004753	active site
164756004754	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
164756004755	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756004756	active site
164756004757	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756004758	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756004759	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
164756004760	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
164756004761	NAD binding site [chemical binding]; other site
164756004762	catalytic residues [active]
164756004763	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756004764	Cytochrome P450; Region: p450; cl12078
164756004765	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
164756004766	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
164756004767	NAD(P) binding site [chemical binding]; other site
164756004768	catalytic residues [active]
164756004769	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756004770	Cytochrome P450; Region: p450; cl12078
164756004771	acyl-CoA synthetase; Validated; Region: PRK07798
164756004772	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756004773	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
164756004774	acyl-activating enzyme (AAE) consensus motif; other site
164756004775	putative AMP binding site [chemical binding]; other site
164756004776	putative active site [active]
164756004777	putative CoA binding site [chemical binding]; other site
164756004778	Isochorismatase family; Region: Isochorismatase; pfam00857
164756004779	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
164756004780	catalytic triad [active]
164756004781	conserved cis-peptide bond; other site
164756004782	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756004783	iron-sulfur cluster [ion binding]; other site
164756004784	[2Fe-2S] cluster binding site [ion binding]; other site
164756004785	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
164756004786	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004787	NAD(P) binding site [chemical binding]; other site
164756004788	active site
164756004789	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756004790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756004791	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756004792	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
164756004793	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756004794	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
164756004795	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
164756004796	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
164756004797	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
164756004798	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756004799	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756004800	Cytochrome P450; Region: p450; cl12078
164756004801	Protein of unknown function (DUF466); Region: DUF466; pfam04328
164756004802	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
164756004803	Carbon starvation protein CstA; Region: CstA; pfam02554
164756004804	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
164756004805	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
164756004806	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
164756004807	active site
164756004808	DNA binding site [nucleotide binding]
164756004809	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
164756004810	DNA binding site [nucleotide binding]
164756004811	Yqey-like protein; Region: YqeY; cl17540
164756004812	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
164756004813	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
164756004814	Moco binding site; other site
164756004815	metal coordination site [ion binding]; other site
164756004816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004817	NAD(P) binding site [chemical binding]; other site
164756004818	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
164756004819	active site
164756004820	Predicted transcriptional regulators [Transcription]; Region: COG1733
164756004821	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756004822	dimerization interface [polypeptide binding]; other site
164756004823	putative DNA binding site [nucleotide binding]; other site
164756004824	putative Zn2+ binding site [ion binding]; other site
164756004825	SCP-2 sterol transfer family; Region: SCP2; cl01225
164756004826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756004827	S-adenosylmethionine binding site [chemical binding]; other site
164756004828	Phosphotransferase enzyme family; Region: APH; pfam01636
164756004829	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
164756004830	putative active site [active]
164756004831	putative substrate binding site [chemical binding]; other site
164756004832	ATP binding site [chemical binding]; other site
164756004833	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
164756004834	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
164756004835	Cytochrome P450; Region: p450; cl12078
164756004836	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756004837	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004839	short chain dehydrogenase; Provisional; Region: PRK07832
164756004840	classical (c) SDRs; Region: SDR_c; cd05233
164756004841	NAD(P) binding site [chemical binding]; other site
164756004842	active site
164756004843	Predicted ATPase [General function prediction only]; Region: COG4637
164756004844	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756004845	Walker A/P-loop; other site
164756004846	ATP binding site [chemical binding]; other site
164756004847	DNA polymerase IV; Validated; Region: PRK03352
164756004848	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
164756004849	active site
164756004850	DNA binding site [nucleotide binding]
164756004851	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004852	Predicted flavoprotein [General function prediction only]; Region: COG0431
164756004853	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
164756004854	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
164756004855	catalytic residues [active]
164756004856	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
164756004857	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
164756004858	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
164756004859	Class I ribonucleotide reductase; Region: RNR_I; cd01679
164756004860	active site
164756004861	dimer interface [polypeptide binding]; other site
164756004862	catalytic residues [active]
164756004863	effector binding site; other site
164756004864	R2 peptide binding site; other site
164756004865	Predicted membrane protein [Function unknown]; Region: COG3174
164756004866	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
164756004867	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
164756004868	dimerization interface [polypeptide binding]; other site
164756004869	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756004870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756004871	NAD(P) binding site [chemical binding]; other site
164756004872	active site
164756004873	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
164756004874	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
164756004875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
164756004876	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004877	agmatinase; Region: agmatinase; TIGR01230
164756004878	Agmatinase-like family; Region: Agmatinase-like; cd09990
164756004879	active site
164756004880	oligomer interface [polypeptide binding]; other site
164756004881	Mn binding site [ion binding]; other site
164756004882	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
164756004883	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756004884	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004885	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004886	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
164756004887	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
164756004888	dimer interface [polypeptide binding]; other site
164756004889	putative radical transfer pathway; other site
164756004890	diiron center [ion binding]; other site
164756004891	tyrosyl radical; other site
164756004892	Domain of unknown function (DUF385); Region: DUF385; pfam04075
164756004893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756004894	metabolite-proton symporter; Region: 2A0106; TIGR00883
164756004895	putative substrate translocation pore; other site
164756004896	Putative esterase; Region: Esterase; pfam00756
164756004897	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
164756004898	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
164756004899	putative NAD(P) binding site [chemical binding]; other site
164756004900	putative substrate binding site [chemical binding]; other site
164756004901	catalytic Zn binding site [ion binding]; other site
164756004902	structural Zn binding site [ion binding]; other site
164756004903	dimer interface [polypeptide binding]; other site
164756004904	YCII-related domain; Region: YCII; cl00999
164756004905	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
164756004906	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
164756004907	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
164756004908	urea carboxylase; Region: urea_carbox; TIGR02712
164756004909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
164756004910	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756004911	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
164756004912	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
164756004913	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
164756004914	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
164756004915	carboxyltransferase (CT) interaction site; other site
164756004916	biotinylation site [posttranslational modification]; other site
164756004917	allophanate hydrolase; Provisional; Region: PRK08186
164756004918	Amidase; Region: Amidase; cl11426
164756004919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756004920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756004921	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
164756004922	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
164756004923	Walker A/P-loop; other site
164756004924	ATP binding site [chemical binding]; other site
164756004925	Q-loop/lid; other site
164756004926	ABC transporter signature motif; other site
164756004927	Walker B; other site
164756004928	D-loop; other site
164756004929	H-loop/switch region; other site
164756004930	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
164756004931	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
164756004932	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
164756004933	Walker A/P-loop; other site
164756004934	ATP binding site [chemical binding]; other site
164756004935	Q-loop/lid; other site
164756004936	ABC transporter signature motif; other site
164756004937	Walker B; other site
164756004938	D-loop; other site
164756004939	H-loop/switch region; other site
164756004940	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
164756004941	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
164756004942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756004943	ABC-ATPase subunit interface; other site
164756004944	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
164756004945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756004946	dimer interface [polypeptide binding]; other site
164756004947	conserved gate region; other site
164756004948	putative PBP binding loops; other site
164756004949	ABC-ATPase subunit interface; other site
164756004950	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
164756004951	catalytic triad [active]
164756004952	Isochorismatase family; Region: Isochorismatase; pfam00857
164756004953	conserved cis-peptide bond; other site
164756004954	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
164756004955	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
164756004956	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756004957	oxidase reductase; Provisional; Region: PTZ00273
164756004958	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
164756004959	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
164756004960	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
164756004961	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
164756004962	siderophore binding site; other site
164756004963	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
164756004964	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
164756004965	D-pathway; other site
164756004966	Putative ubiquinol binding site [chemical binding]; other site
164756004967	Low-spin heme (heme b) binding site [chemical binding]; other site
164756004968	Putative water exit pathway; other site
164756004969	Binuclear center (heme o3/CuB) [ion binding]; other site
164756004970	K-pathway; other site
164756004971	Putative proton exit pathway; other site
164756004972	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
164756004973	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
164756004974	phosphoserine phosphatase SerB; Region: serB; TIGR00338
164756004975	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756004976	motif II; other site
164756004977	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
164756004978	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756004979	DNA-binding site [nucleotide binding]; DNA binding site
164756004980	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756004981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756004982	homodimer interface [polypeptide binding]; other site
164756004983	catalytic residue [active]
164756004984	Predicted membrane protein [Function unknown]; Region: COG2364
164756004985	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
164756004986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756004987	Walker A/P-loop; other site
164756004988	ATP binding site [chemical binding]; other site
164756004989	Q-loop/lid; other site
164756004990	ABC transporter signature motif; other site
164756004991	Walker B; other site
164756004992	D-loop; other site
164756004993	H-loop/switch region; other site
164756004994	NUDIX domain; Region: NUDIX; pfam00293
164756004995	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756004996	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756004997	substrate binding site [chemical binding]; other site
164756004998	oxyanion hole (OAH) forming residues; other site
164756004999	trimer interface [polypeptide binding]; other site
164756005000	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
164756005001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756005002	S-adenosylmethionine binding site [chemical binding]; other site
164756005003	Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263
164756005004	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
164756005005	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
164756005006	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
164756005007	FOG: WD40-like repeat [Function unknown]; Region: COG1520
164756005008	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
164756005009	active site
164756005010	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
164756005011	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
164756005012	trimer interface [polypeptide binding]; other site
164756005013	active site
164756005014	substrate binding site [chemical binding]; other site
164756005015	CoA binding site [chemical binding]; other site
164756005016	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756005017	active site
164756005018	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756005019	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756005020	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
164756005021	Uncharacterized conserved protein [Function unknown]; Region: COG1543
164756005022	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
164756005023	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
164756005024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756005025	S-adenosylmethionine binding site [chemical binding]; other site
164756005026	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
164756005027	Ligand binding site [chemical binding]; other site
164756005028	Electron transfer flavoprotein domain; Region: ETF; pfam01012
164756005029	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
164756005030	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
164756005031	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
164756005032	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756005033	classical (c) SDRs; Region: SDR_c; cd05233
164756005034	NAD(P) binding site [chemical binding]; other site
164756005035	active site
164756005036	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
164756005037	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756005038	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
164756005039	putative acyl-acceptor binding pocket; other site
164756005040	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
164756005041	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
164756005042	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756005043	catalytic residue [active]
164756005044	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
164756005045	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
164756005046	Ligand Binding Site [chemical binding]; other site
164756005047	PknH-like extracellular domain; Region: PknH_C; pfam14032
164756005048	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
164756005049	4-coumarate--CoA ligase; Region: PLN02246
164756005050	4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904
164756005051	acyl-activating enzyme (AAE) consensus motif; other site
164756005052	active site
164756005053	putative CoA binding site [chemical binding]; other site
164756005054	AMP binding site [chemical binding]; other site
164756005055	Protein of unknown function (DUF419); Region: DUF419; pfam04237
164756005056	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
164756005057	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
164756005058	nucleotide binding pocket [chemical binding]; other site
164756005059	K-X-D-G motif; other site
164756005060	catalytic site [active]
164756005061	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
164756005062	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
164756005063	Helix-hairpin-helix motif; Region: HHH; pfam00633
164756005064	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
164756005065	Dimer interface [polypeptide binding]; other site
164756005066	BRCT sequence motif; other site
164756005067	spermidine synthase; Provisional; Region: PRK03612
164756005068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756005069	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
164756005070	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
164756005071	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
164756005072	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
164756005073	Hemerythrin-like domain; Region: Hr-like; cd12108
164756005074	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
164756005075	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
164756005076	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
164756005077	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
164756005078	6-phosphofructokinase; Provisional; Region: PRK03202
164756005079	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
164756005080	active site
164756005081	ADP/pyrophosphate binding site [chemical binding]; other site
164756005082	dimerization interface [polypeptide binding]; other site
164756005083	allosteric effector site; other site
164756005084	fructose-1,6-bisphosphate binding site; other site
164756005085	Cutinase; Region: Cutinase; pfam01083
164756005086	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
164756005087	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
164756005088	GatB domain; Region: GatB_Yqey; pfam02637
164756005089	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
164756005090	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756005091	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756005092	enoyl-CoA hydratase; Provisional; Region: PRK06495
164756005093	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756005094	substrate binding site [chemical binding]; other site
164756005095	oxyanion hole (OAH) forming residues; other site
164756005096	trimer interface [polypeptide binding]; other site
164756005097	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756005098	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756005099	active site
164756005100	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
164756005101	Phosphotransferase enzyme family; Region: APH; pfam01636
164756005102	putative active site [active]
164756005103	putative substrate binding site [chemical binding]; other site
164756005104	ATP binding site [chemical binding]; other site
164756005105	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
164756005106	classical (c) SDRs; Region: SDR_c; cd05233
164756005107	NAD(P) binding site [chemical binding]; other site
164756005108	active site
164756005109	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
164756005110	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
164756005111	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
164756005112	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
164756005113	PYR/PP interface [polypeptide binding]; other site
164756005114	dimer interface [polypeptide binding]; other site
164756005115	TPP binding site [chemical binding]; other site
164756005116	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
164756005117	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
164756005118	TPP-binding site [chemical binding]; other site
164756005119	dimer interface [polypeptide binding]; other site
164756005120	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
164756005121	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
164756005122	putative valine binding site [chemical binding]; other site
164756005123	dimer interface [polypeptide binding]; other site
164756005124	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
164756005125	ketol-acid reductoisomerase; Provisional; Region: PRK05479
164756005126	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
164756005127	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
164756005128	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
164756005129	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756005130	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
164756005131	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
164756005132	ligand binding site [chemical binding]; other site
164756005133	NAD binding site [chemical binding]; other site
164756005134	dimerization interface [polypeptide binding]; other site
164756005135	catalytic site [active]
164756005136	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
164756005137	putative L-serine binding site [chemical binding]; other site
164756005138	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
164756005139	tartrate dehydrogenase; Region: TTC; TIGR02089
164756005140	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
164756005141	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
164756005142	active site
164756005143	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
164756005144	MarR family; Region: MarR_2; pfam12802
164756005145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756005146	putative substrate translocation pore; other site
164756005147	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756005148	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756005149	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
164756005150	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
164756005151	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
164756005152	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
164756005153	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
164756005154	active site
164756005155	HIGH motif; other site
164756005156	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
164756005157	active site
164756005158	KMSKS motif; other site
164756005159	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
164756005160	Transcriptional regulator [Transcription]; Region: IclR; COG1414
164756005161	Bacterial transcriptional regulator; Region: IclR; pfam01614
164756005162	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
164756005163	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
164756005164	substrate binding site [chemical binding]; other site
164756005165	ligand binding site [chemical binding]; other site
164756005166	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
164756005167	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
164756005168	substrate binding site [chemical binding]; other site
164756005169	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
164756005170	IHF - DNA interface [nucleotide binding]; other site
164756005171	IHF dimer interface [polypeptide binding]; other site
164756005172	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
164756005173	active site
164756005174	Ap6A binding site [chemical binding]; other site
164756005175	nudix motif; other site
164756005176	metal binding site [ion binding]; metal-binding site
164756005177	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756005178	catalytic core [active]
164756005179	polyphosphate kinase; Provisional; Region: PRK05443
164756005180	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
164756005181	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
164756005182	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
164756005183	putative domain interface [polypeptide binding]; other site
164756005184	putative active site [active]
164756005185	catalytic site [active]
164756005186	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
164756005187	putative active site [active]
164756005188	catalytic site [active]
164756005189	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
164756005190	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
164756005191	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
164756005192	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
164756005193	cystathionine gamma-lyase; Validated; Region: PRK07582
164756005194	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
164756005195	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756005196	catalytic residue [active]
164756005197	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
164756005198	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
164756005199	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756005200	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
164756005201	AsnC family; Region: AsnC_trans_reg; pfam01037
164756005202	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
164756005203	thiamine monophosphate kinase; Provisional; Region: PRK05731
164756005204	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
164756005205	ATP binding site [chemical binding]; other site
164756005206	dimerization interface [polypeptide binding]; other site
164756005207	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
164756005208	ligand binding site [chemical binding]; other site
164756005209	active site
164756005210	UGI interface [polypeptide binding]; other site
164756005211	catalytic site [active]
164756005212	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
164756005213	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
164756005214	DAK2 domain; Region: Dak2; pfam02734
164756005215	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
164756005216	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
164756005217	generic binding surface II; other site
164756005218	ssDNA binding site; other site
164756005219	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756005220	ATP binding site [chemical binding]; other site
164756005221	putative Mg++ binding site [ion binding]; other site
164756005222	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756005223	nucleotide binding region [chemical binding]; other site
164756005224	ATP-binding site [chemical binding]; other site
164756005225	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
164756005226	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
164756005227	active site
164756005228	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
164756005229	catalytic tetrad [active]
164756005230	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
164756005231	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
164756005232	active site
164756005233	catalytic tetrad [active]
164756005234	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756005235	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756005236	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
164756005237	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
164756005238	catalytic residues [active]
164756005239	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
164756005240	putative active site [active]
164756005241	redox center [active]
164756005242	pyruvate carboxylase; Reviewed; Region: PRK12999
164756005243	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
164756005244	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756005245	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
164756005246	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
164756005247	active site
164756005248	catalytic residues [active]
164756005249	metal binding site [ion binding]; metal-binding site
164756005250	homodimer binding site [polypeptide binding]; other site
164756005251	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
164756005252	carboxyltransferase (CT) interaction site; other site
164756005253	biotinylation site [posttranslational modification]; other site
164756005254	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
164756005255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756005256	S-adenosylmethionine binding site [chemical binding]; other site
164756005257	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
164756005258	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
164756005259	active site
164756005260	(T/H)XGH motif; other site
164756005261	Hemerythrin-like domain; Region: Hr-like; cd12108
164756005262	Fe binding site [ion binding]; other site
164756005263	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
164756005264	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
164756005265	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
164756005266	ribonuclease III; Reviewed; Region: rnc; PRK00102
164756005267	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
164756005268	dimerization interface [polypeptide binding]; other site
164756005269	active site
164756005270	metal binding site [ion binding]; metal-binding site
164756005271	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
164756005272	dsRNA binding site [nucleotide binding]; other site
164756005273	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
164756005274	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
164756005275	DNA binding site [nucleotide binding]
164756005276	catalytic residue [active]
164756005277	H2TH interface [polypeptide binding]; other site
164756005278	putative catalytic residues [active]
164756005279	turnover-facilitating residue; other site
164756005280	intercalation triad [nucleotide binding]; other site
164756005281	8OG recognition residue [nucleotide binding]; other site
164756005282	putative reading head residues; other site
164756005283	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
164756005284	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
164756005285	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
164756005286	acylphosphatase; Provisional; Region: PRK14422
164756005287	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
164756005288	AAA domain; Region: AAA_23; pfam13476
164756005289	Walker A/P-loop; other site
164756005290	ATP binding site [chemical binding]; other site
164756005291	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
164756005292	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
164756005293	ABC transporter signature motif; other site
164756005294	Walker B; other site
164756005295	D-loop; other site
164756005296	H-loop/switch region; other site
164756005297	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
164756005298	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
164756005299	homotetramer interface [polypeptide binding]; other site
164756005300	FMN binding site [chemical binding]; other site
164756005301	homodimer contacts [polypeptide binding]; other site
164756005302	putative active site [active]
164756005303	putative substrate binding site [chemical binding]; other site
164756005304	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
164756005305	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
164756005306	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756005307	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
164756005308	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
164756005309	Nitrogen regulatory protein P-II; Region: P-II; smart00938
164756005310	PII uridylyl-transferase; Provisional; Region: PRK03381
164756005311	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
164756005312	metal binding triad; other site
164756005313	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
164756005314	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
164756005315	Zn2+ binding site [ion binding]; other site
164756005316	Mg2+ binding site [ion binding]; other site
164756005317	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
164756005318	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
164756005319	signal recognition particle protein; Provisional; Region: PRK10867
164756005320	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
164756005321	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
164756005322	P loop; other site
164756005323	GTP binding site [chemical binding]; other site
164756005324	Signal peptide binding domain; Region: SRP_SPB; pfam02978
164756005325	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
164756005326	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756005327	active site
164756005328	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
164756005329	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
164756005330	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
164756005331	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
164756005332	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
164756005333	SnoaL-like domain; Region: SnoaL_3; pfam13474
164756005334	Methyltransferase domain; Region: Methyltransf_11; pfam08241
164756005335	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521
164756005336	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
164756005337	hypothetical protein; Provisional; Region: PRK02821
164756005338	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
164756005339	G-X-X-G motif; other site
164756005340	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
164756005341	RimM N-terminal domain; Region: RimM; pfam01782
164756005342	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
164756005343	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
164756005344	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
164756005345	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
164756005346	Catalytic site [active]
164756005347	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
164756005348	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
164756005349	RNA/DNA hybrid binding site [nucleotide binding]; other site
164756005350	active site
164756005351	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
164756005352	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756005353	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756005354	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756005355	UMP phosphatase; Provisional; Region: PRK10444
164756005356	active site
164756005357	motif I; other site
164756005358	motif II; other site
164756005359	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756005360	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
164756005361	TPP-binding site [chemical binding]; other site
164756005362	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
164756005363	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
164756005364	PYR/PP interface [polypeptide binding]; other site
164756005365	dimer interface [polypeptide binding]; other site
164756005366	TPP binding site [chemical binding]; other site
164756005367	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
164756005368	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
164756005369	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756005370	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
164756005371	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
164756005372	active site
164756005373	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
164756005374	catalytic triad [active]
164756005375	dimer interface [polypeptide binding]; other site
164756005376	AMP-binding enzyme; Region: AMP-binding; pfam00501
164756005377	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756005378	active site
164756005379	CoA binding site [chemical binding]; other site
164756005380	AMP binding site [chemical binding]; other site
164756005381	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
164756005382	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
164756005383	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
164756005384	Walker A/P-loop; other site
164756005385	ATP binding site [chemical binding]; other site
164756005386	Q-loop/lid; other site
164756005387	ABC transporter signature motif; other site
164756005388	Walker B; other site
164756005389	D-loop; other site
164756005390	H-loop/switch region; other site
164756005391	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
164756005392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756005393	dimer interface [polypeptide binding]; other site
164756005394	conserved gate region; other site
164756005395	ABC-ATPase subunit interface; other site
164756005396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756005397	dimer interface [polypeptide binding]; other site
164756005398	conserved gate region; other site
164756005399	ABC-ATPase subunit interface; other site
164756005400	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
164756005401	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
164756005402	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
164756005403	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
164756005404	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
164756005405	hypothetical protein; Reviewed; Region: PRK12497
164756005406	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
164756005407	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
164756005408	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
164756005409	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
164756005410	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
164756005411	DNA protecting protein DprA; Region: dprA; TIGR00732
164756005412	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
164756005413	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
164756005414	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
164756005415	FAD binding pocket [chemical binding]; other site
164756005416	FAD binding motif [chemical binding]; other site
164756005417	phosphate binding motif [ion binding]; other site
164756005418	NAD binding pocket [chemical binding]; other site
164756005419	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
164756005420	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
164756005421	putative active site [active]
164756005422	putative substrate binding site [chemical binding]; other site
164756005423	putative FMN binding site [chemical binding]; other site
164756005424	putative catalytic residues [active]
164756005425	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
164756005426	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
164756005427	active site
164756005428	DNA binding site [nucleotide binding]
164756005429	Int/Topo IB signature motif; other site
164756005430	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
164756005431	Peptidase family M23; Region: Peptidase_M23; pfam01551
164756005432	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
164756005433	rRNA interaction site [nucleotide binding]; other site
164756005434	S8 interaction site; other site
164756005435	putative laminin-1 binding site; other site
164756005436	elongation factor Ts; Provisional; Region: tsf; PRK09377
164756005437	UBA/TS-N domain; Region: UBA; pfam00627
164756005438	Elongation factor TS; Region: EF_TS; pfam00889
164756005439	Elongation factor TS; Region: EF_TS; pfam00889
164756005440	amidase; Provisional; Region: PRK07869
164756005441	Amidase; Region: Amidase; cl11426
164756005442	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
164756005443	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
164756005444	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
164756005445	Walker A/P-loop; other site
164756005446	ATP binding site [chemical binding]; other site
164756005447	Q-loop/lid; other site
164756005448	ABC transporter signature motif; other site
164756005449	Walker B; other site
164756005450	D-loop; other site
164756005451	H-loop/switch region; other site
164756005452	Amino acid permease; Region: AA_permease_2; pfam13520
164756005453	tyramine oxidase; Provisional; Region: tynA; PRK11504
164756005454	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
164756005455	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
164756005456	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
164756005457	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
164756005458	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
164756005459	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
164756005460	dimerization interface [polypeptide binding]; other site
164756005461	ligand binding site [chemical binding]; other site
164756005462	NADP binding site [chemical binding]; other site
164756005463	catalytic site [active]
164756005464	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
164756005465	putative nucleotide binding site [chemical binding]; other site
164756005466	uridine monophosphate binding site [chemical binding]; other site
164756005467	homohexameric interface [polypeptide binding]; other site
164756005468	ribosome recycling factor; Reviewed; Region: frr; PRK00083
164756005469	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
164756005470	hinge region; other site
164756005471	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
164756005472	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
164756005473	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
164756005474	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756005475	FeS/SAM binding site; other site
164756005476	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
164756005477	SnoaL-like domain; Region: SnoaL_3; pfam13474
164756005478	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
164756005479	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
164756005480	NAD binding site [chemical binding]; other site
164756005481	catalytic residues [active]
164756005482	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756005483	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
164756005484	molybdopterin cofactor binding site; other site
164756005485	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
164756005486	putative molybdopterin cofactor binding site; other site
164756005487	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756005488	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756005489	Ecdysteroid kinase; Region: EcKinase; cl17738
164756005490	Phosphotransferase enzyme family; Region: APH; pfam01636
164756005491	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756005492	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756005493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756005494	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756005495	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756005496	Cytochrome P450; Region: p450; cl12078
164756005497	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756005498	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
164756005499	YacP-like NYN domain; Region: NYN_YacP; cl01491
164756005500	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
164756005501	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
164756005502	Strictosidine synthase; Region: Str_synth; pfam03088
164756005503	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756005504	Cytochrome P450; Region: p450; cl12078
164756005505	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
164756005506	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756005507	NAD(P) binding site [chemical binding]; other site
164756005508	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
164756005509	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
164756005510	classical (c) SDRs; Region: SDR_c; cd05233
164756005511	NAD(P) binding site [chemical binding]; other site
164756005512	active site
164756005513	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756005514	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756005515	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
164756005516	putative active site [active]
164756005517	putative substrate binding site [chemical binding]; other site
164756005518	ATP binding site [chemical binding]; other site
164756005519	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756005520	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756005521	hydrophobic ligand binding site; other site
164756005522	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756005523	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756005524	active site
164756005525	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
164756005526	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756005527	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756005528	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756005529	Domain of unknown function (DUF427); Region: DUF427; pfam04248
164756005530	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756005531	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756005532	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
164756005533	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
164756005534	FAD binding domain; Region: FAD_binding_4; pfam01565
164756005535	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
164756005536	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
164756005537	DNA photolyase; Region: DNA_photolyase; pfam00875
164756005538	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
164756005539	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
164756005540	active site
164756005541	catalytic site [active]
164756005542	tetramer interface [polypeptide binding]; other site
164756005543	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
164756005544	Fasciclin domain; Region: Fasciclin; pfam02469
164756005545	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
164756005546	Fasciclin domain; Region: Fasciclin; pfam02469
164756005547	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
164756005548	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
164756005549	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
164756005550	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
164756005551	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
164756005552	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
164756005553	active site
164756005554	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
164756005555	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
164756005556	putative substrate binding region [chemical binding]; other site
164756005557	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
164756005558	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
164756005559	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
164756005560	Predicted acetyltransferase [General function prediction only]; Region: COG3393
164756005561	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
164756005562	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
164756005563	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
164756005564	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
164756005565	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
164756005566	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
164756005567	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756005568	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
164756005569	CoenzymeA binding site [chemical binding]; other site
164756005570	subunit interaction site [polypeptide binding]; other site
164756005571	PHB binding site; other site
164756005572	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
164756005573	active site
164756005574	cobyric acid synthase; Provisional; Region: PRK00784
164756005575	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756005576	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756005577	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
164756005578	catalytic triad [active]
164756005579	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756005580	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
164756005581	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756005582	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
164756005583	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
164756005584	active site
164756005585	dimer interface [polypeptide binding]; other site
164756005586	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
164756005587	Ligand Binding Site [chemical binding]; other site
164756005588	Molecular Tunnel; other site
164756005589	ethanolamine permease; Region: 2A0305; TIGR00908
164756005590	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
164756005591	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
164756005592	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756005593	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
164756005594	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
164756005595	catalytic triad [active]
164756005596	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756005597	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
164756005598	NAD(P) binding site [chemical binding]; other site
164756005599	catalytic residues [active]
164756005600	short chain dehydrogenase; Provisional; Region: PRK06057
164756005601	classical (c) SDRs; Region: SDR_c; cd05233
164756005602	NAD(P) binding site [chemical binding]; other site
164756005603	active site
164756005604	Transcriptional regulators [Transcription]; Region: FadR; COG2186
164756005605	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756005606	DNA-binding site [nucleotide binding]; DNA binding site
164756005607	FCD domain; Region: FCD; pfam07729
164756005608	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756005609	dimerization interface [polypeptide binding]; other site
164756005610	putative DNA binding site [nucleotide binding]; other site
164756005611	putative Zn2+ binding site [ion binding]; other site
164756005612	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310
164756005613	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
164756005614	PDGLE domain; Region: PDGLE; pfam13190
164756005615	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
164756005616	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
164756005617	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
164756005618	Walker A/P-loop; other site
164756005619	ATP binding site [chemical binding]; other site
164756005620	Q-loop/lid; other site
164756005621	ABC transporter signature motif; other site
164756005622	Walker B; other site
164756005623	D-loop; other site
164756005624	H-loop/switch region; other site
164756005625	mycothione reductase; Reviewed; Region: PRK07846
164756005626	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756005627	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756005628	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
164756005629	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
164756005630	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756005631	malate:quinone oxidoreductase; Validated; Region: PRK05257
164756005632	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
164756005633	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
164756005634	Coenzyme A binding pocket [chemical binding]; other site
164756005635	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
164756005636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756005637	Walker A motif; other site
164756005638	ATP binding site [chemical binding]; other site
164756005639	Walker B motif; other site
164756005640	arginine finger; other site
164756005641	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
164756005642	metal ion-dependent adhesion site (MIDAS); other site
164756005643	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
164756005644	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
164756005645	Walker A motif; other site
164756005646	homodimer interface [polypeptide binding]; other site
164756005647	ATP binding site [chemical binding]; other site
164756005648	hydroxycobalamin binding site [chemical binding]; other site
164756005649	Walker B motif; other site
164756005650	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
164756005651	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
164756005652	catalytic triad [active]
164756005653	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
164756005654	siroheme synthase; Provisional; Region: cysG; PRK10637
164756005655	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
164756005656	homodimer interface [polypeptide binding]; other site
164756005657	active site
164756005658	SAM binding site [chemical binding]; other site
164756005659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756005660	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756005661	putative substrate translocation pore; other site
164756005662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756005663	prolyl-tRNA synthetase; Provisional; Region: PRK09194
164756005664	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
164756005665	dimer interface [polypeptide binding]; other site
164756005666	motif 1; other site
164756005667	active site
164756005668	motif 2; other site
164756005669	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
164756005670	putative deacylase active site [active]
164756005671	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
164756005672	active site
164756005673	motif 3; other site
164756005674	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
164756005675	anticodon binding site; other site
164756005676	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
164756005677	dinuclear metal binding motif [ion binding]; other site
164756005678	ribosome maturation protein RimP; Reviewed; Region: PRK00092
164756005679	Sm and related proteins; Region: Sm_like; cl00259
164756005680	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
164756005681	putative oligomer interface [polypeptide binding]; other site
164756005682	putative RNA binding site [nucleotide binding]; other site
164756005683	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
164756005684	NusA N-terminal domain; Region: NusA_N; pfam08529
164756005685	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
164756005686	RNA binding site [nucleotide binding]; other site
164756005687	homodimer interface [polypeptide binding]; other site
164756005688	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
164756005689	G-X-X-G motif; other site
164756005690	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
164756005691	G-X-X-G motif; other site
164756005692	Protein of unknown function (DUF448); Region: DUF448; pfam04296
164756005693	putative RNA binding cleft [nucleotide binding]; other site
164756005694	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
164756005695	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
164756005696	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
164756005697	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
164756005698	G1 box; other site
164756005699	putative GEF interaction site [polypeptide binding]; other site
164756005700	GTP/Mg2+ binding site [chemical binding]; other site
164756005701	Switch I region; other site
164756005702	G2 box; other site
164756005703	G3 box; other site
164756005704	Switch II region; other site
164756005705	G4 box; other site
164756005706	G5 box; other site
164756005707	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
164756005708	Translation-initiation factor 2; Region: IF-2; pfam11987
164756005709	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
164756005710	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
164756005711	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
164756005712	DHH family; Region: DHH; pfam01368
164756005713	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
164756005714	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
164756005715	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756005716	S-adenosylmethionine binding site [chemical binding]; other site
164756005717	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
164756005718	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756005719	DNA binding residues [nucleotide binding]
164756005720	dimer interface [polypeptide binding]; other site
164756005721	enoyl-CoA hydratase; Provisional; Region: PRK06190
164756005722	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756005723	substrate binding site [chemical binding]; other site
164756005724	oxyanion hole (OAH) forming residues; other site
164756005725	trimer interface [polypeptide binding]; other site
164756005726	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
164756005727	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
164756005728	Predicted acyl esterases [General function prediction only]; Region: COG2936
164756005729	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
164756005730	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
164756005731	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
164756005732	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
164756005733	active site
164756005734	metal binding site [ion binding]; metal-binding site
164756005735	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
164756005736	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
164756005737	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
164756005738	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
164756005739	RNA binding site [nucleotide binding]; other site
164756005740	active site
164756005741	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
164756005742	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
164756005743	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
164756005744	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756005745	putative DNA binding site [nucleotide binding]; other site
164756005746	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
164756005747	FeoA domain; Region: FeoA; pfam04023
164756005748	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
164756005749	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
164756005750	active site
164756005751	Riboflavin kinase; Region: Flavokinase; pfam01687
164756005752	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
164756005753	16S/18S rRNA binding site [nucleotide binding]; other site
164756005754	S13e-L30e interaction site [polypeptide binding]; other site
164756005755	25S rRNA binding site [nucleotide binding]; other site
164756005756	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
164756005757	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
164756005758	oligomer interface [polypeptide binding]; other site
164756005759	RNA binding site [nucleotide binding]; other site
164756005760	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
164756005761	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
164756005762	RNase E interface [polypeptide binding]; other site
164756005763	trimer interface [polypeptide binding]; other site
164756005764	active site
164756005765	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
164756005766	putative nucleic acid binding region [nucleotide binding]; other site
164756005767	G-X-X-G motif; other site
164756005768	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
164756005769	RNA binding site [nucleotide binding]; other site
164756005770	domain interface; other site
164756005771	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
164756005772	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
164756005773	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
164756005774	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
164756005775	hypothetical protein; Provisional; Region: PRK01842
164756005776	SEC-C motif; Region: SEC-C; pfam02810
164756005777	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
164756005778	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
164756005779	hexamer interface [polypeptide binding]; other site
164756005780	ligand binding site [chemical binding]; other site
164756005781	putative active site [active]
164756005782	NAD(P) binding site [chemical binding]; other site
164756005783	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
164756005784	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756005785	putative DNA binding site [nucleotide binding]; other site
164756005786	putative Zn2+ binding site [ion binding]; other site
164756005787	AsnC family; Region: AsnC_trans_reg; pfam01037
164756005788	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756005789	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756005790	active site
164756005791	dihydrodipicolinate reductase; Provisional; Region: PRK00048
164756005792	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756005793	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
164756005794	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
164756005795	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
164756005796	Dienelactone hydrolase family; Region: DLH; pfam01738
164756005797	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
164756005798	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
164756005799	thymidylate synthase; Reviewed; Region: thyA; PRK01827
164756005800	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
164756005801	dimerization interface [polypeptide binding]; other site
164756005802	active site
164756005803	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
164756005804	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
164756005805	folate binding site [chemical binding]; other site
164756005806	NADP+ binding site [chemical binding]; other site
164756005807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
164756005808	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
164756005809	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
164756005810	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
164756005811	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
164756005812	dimer interface [polypeptide binding]; other site
164756005813	active site
164756005814	catalytic residue [active]
164756005815	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
164756005816	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756005817	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
164756005818	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
164756005819	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756005820	NAD(P) binding site [chemical binding]; other site
164756005821	active site
164756005822	Uncharacterized conserved protein [Function unknown]; Region: COG1359
164756005823	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
164756005824	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756005825	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
164756005826	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756005827	Coenzyme A binding pocket [chemical binding]; other site
164756005828	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
164756005829	Competence-damaged protein; Region: CinA; pfam02464
164756005830	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
164756005831	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756005832	non-specific DNA binding site [nucleotide binding]; other site
164756005833	salt bridge; other site
164756005834	sequence-specific DNA binding site [nucleotide binding]; other site
164756005835	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
164756005836	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
164756005837	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
164756005838	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
164756005839	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
164756005840	dimerization interface [polypeptide binding]; other site
164756005841	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
164756005842	ATP binding site [chemical binding]; other site
164756005843	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
164756005844	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
164756005845	HupF/HypC family; Region: HupF_HypC; pfam01455
164756005846	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
164756005847	Acylphosphatase; Region: Acylphosphatase; pfam00708
164756005848	HypF finger; Region: zf-HYPF; pfam07503
164756005849	HypF finger; Region: zf-HYPF; pfam07503
164756005850	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
164756005851	HupF/HypC family; Region: HupF_HypC; pfam01455
164756005852	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
164756005853	nickel binding site [ion binding]; other site
164756005854	NifU-like domain; Region: NifU; cl00484
164756005855	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756005856	iron-sulfur cluster [ion binding]; other site
164756005857	[2Fe-2S] cluster binding site [ion binding]; other site
164756005858	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
164756005859	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
164756005860	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
164756005861	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756005862	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
164756005863	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
164756005864	recombinase A; Provisional; Region: recA; PRK09354
164756005865	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
164756005866	hexamer interface [polypeptide binding]; other site
164756005867	Walker A motif; other site
164756005868	ATP binding site [chemical binding]; other site
164756005869	Walker B motif; other site
164756005870	recombination regulator RecX; Reviewed; Region: recX; PRK00117
164756005871	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756005872	MarR family; Region: MarR_2; pfam12802
164756005873	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
164756005874	TIGR03086 family protein; Region: TIGR03086
164756005875	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
164756005876	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756005877	dimer interface [polypeptide binding]; other site
164756005878	conserved gate region; other site
164756005879	putative PBP binding loops; other site
164756005880	ABC-ATPase subunit interface; other site
164756005881	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
164756005882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756005883	dimer interface [polypeptide binding]; other site
164756005884	conserved gate region; other site
164756005885	putative PBP binding loops; other site
164756005886	ABC-ATPase subunit interface; other site
164756005887	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
164756005888	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756005889	substrate binding pocket [chemical binding]; other site
164756005890	membrane-bound complex binding site; other site
164756005891	hinge residues; other site
164756005892	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
164756005893	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
164756005894	Walker A/P-loop; other site
164756005895	ATP binding site [chemical binding]; other site
164756005896	Q-loop/lid; other site
164756005897	ABC transporter signature motif; other site
164756005898	Walker B; other site
164756005899	D-loop; other site
164756005900	H-loop/switch region; other site
164756005901	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
164756005902	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
164756005903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756005904	FeS/SAM binding site; other site
164756005905	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
164756005906	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
164756005907	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
164756005908	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
164756005909	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
164756005910	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
164756005911	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
164756005912	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
164756005913	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
164756005914	GTPases [General function prediction only]; Region: HflX; COG2262
164756005915	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
164756005916	HflX GTPase family; Region: HflX; cd01878
164756005917	G1 box; other site
164756005918	GTP/Mg2+ binding site [chemical binding]; other site
164756005919	Switch I region; other site
164756005920	G2 box; other site
164756005921	G3 box; other site
164756005922	Switch II region; other site
164756005923	G4 box; other site
164756005924	G5 box; other site
164756005925	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
164756005926	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
164756005927	ATP binding site [chemical binding]; other site
164756005928	Mg++ binding site [ion binding]; other site
164756005929	motif III; other site
164756005930	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756005931	nucleotide binding region [chemical binding]; other site
164756005932	ATP-binding site [chemical binding]; other site
164756005933	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
164756005934	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
164756005935	molybdopterin cofactor binding site [chemical binding]; other site
164756005936	substrate binding site [chemical binding]; other site
164756005937	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
164756005938	molybdopterin cofactor binding site; other site
164756005939	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
164756005940	LGFP repeat; Region: LGFP; pfam08310
164756005941	LGFP repeat; Region: LGFP; pfam08310
164756005942	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
164756005943	LexA repressor; Validated; Region: PRK00215
164756005944	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
164756005945	Catalytic site [active]
164756005946	LysM domain; Region: LysM; pfam01476
164756005947	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
164756005948	ATP cone domain; Region: ATP-cone; pfam03477
164756005949	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
164756005950	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756005951	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
164756005952	PAC2 family; Region: PAC2; pfam09754
164756005953	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
164756005954	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
164756005955	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
164756005956	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
164756005957	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
164756005958	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
164756005959	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
164756005960	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
164756005961	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756005962	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
164756005963	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756005964	DNA binding residues [nucleotide binding]
164756005965	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
164756005966	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
164756005967	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
164756005968	Protein of unknown function (DUF952); Region: DUF952; pfam06108
164756005969	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
164756005970	homotrimer interaction site [polypeptide binding]; other site
164756005971	putative active site [active]
164756005972	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
164756005973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756005974	S-adenosylmethionine binding site [chemical binding]; other site
164756005975	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
164756005976	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756005977	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
164756005978	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756005979	DNA binding residues [nucleotide binding]
164756005980	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
164756005981	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756005982	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
164756005983	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
164756005984	active site
164756005985	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
164756005986	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
164756005987	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
164756005988	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
164756005989	trimer interface [polypeptide binding]; other site
164756005990	active site
164756005991	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
164756005992	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
164756005993	generic binding surface II; other site
164756005994	ssDNA binding site; other site
164756005995	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
164756005996	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
164756005997	TrkA-N domain; Region: TrkA_N; pfam02254
164756005998	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
164756005999	TrkA-N domain; Region: TrkA_N; pfam02254
164756006000	TrkA-C domain; Region: TrkA_C; pfam02080
164756006001	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
164756006002	TRAM domain; Region: TRAM; pfam01938
164756006003	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
164756006004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
164756006005	MarR family; Region: MarR_2; pfam12802
164756006006	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
164756006007	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
164756006008	Walker A/P-loop; other site
164756006009	ATP binding site [chemical binding]; other site
164756006010	Q-loop/lid; other site
164756006011	ABC transporter signature motif; other site
164756006012	Walker B; other site
164756006013	D-loop; other site
164756006014	H-loop/switch region; other site
164756006015	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
164756006016	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
164756006017	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
164756006018	Walker A/P-loop; other site
164756006019	ATP binding site [chemical binding]; other site
164756006020	Q-loop/lid; other site
164756006021	ABC transporter signature motif; other site
164756006022	Walker B; other site
164756006023	D-loop; other site
164756006024	H-loop/switch region; other site
164756006025	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
164756006026	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
164756006027	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
164756006028	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
164756006029	TPP-binding site; other site
164756006030	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
164756006031	PYR/PP interface [polypeptide binding]; other site
164756006032	dimer interface [polypeptide binding]; other site
164756006033	TPP binding site [chemical binding]; other site
164756006034	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
164756006035	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
164756006036	putative active site [active]
164756006037	putative metal binding site [ion binding]; other site
164756006038	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
164756006039	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
164756006040	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
164756006041	catalytic site [active]
164756006042	putative active site [active]
164756006043	putative substrate binding site [chemical binding]; other site
164756006044	Helicase and RNase D C-terminal; Region: HRDC; smart00341
164756006045	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
164756006046	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
164756006047	substrate binding site [chemical binding]; other site
164756006048	active site
164756006049	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
164756006050	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756006051	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
164756006052	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756006053	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756006054	metal binding site [ion binding]; metal-binding site
164756006055	active site
164756006056	I-site; other site
164756006057	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
164756006058	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
164756006059	SelR domain; Region: SelR; pfam01641
164756006060	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
164756006061	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756006062	TAP-like protein; Region: Abhydrolase_4; pfam08386
164756006063	hypothetical protein; Provisional; Region: PRK14059
164756006064	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
164756006065	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
164756006066	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
164756006067	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
164756006068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756006069	Coenzyme A binding pocket [chemical binding]; other site
164756006070	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
164756006071	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
164756006072	DNA binding site [nucleotide binding]
164756006073	active site
164756006074	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
164756006075	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756006076	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756006077	DNA binding residues [nucleotide binding]
164756006078	Clp amino terminal domain; Region: Clp_N; pfam02861
164756006079	Clp amino terminal domain; Region: Clp_N; pfam02861
164756006080	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756006081	hydrophobic ligand binding site; other site
164756006082	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756006083	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756006084	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756006085	Asp23 family; Region: Asp23; pfam03780
164756006086	Asp23 family; Region: Asp23; pfam03780
164756006087	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
164756006088	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
164756006089	GAF domain; Region: GAF; pfam01590
164756006090	GAF domain; Region: GAF_2; pfam13185
164756006091	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
164756006092	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
164756006093	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756006094	CoenzymeA binding site [chemical binding]; other site
164756006095	subunit interaction site [polypeptide binding]; other site
164756006096	PHB binding site; other site
164756006097	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
164756006098	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
164756006099	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
164756006100	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
164756006101	active site
164756006102	dimer interface [polypeptide binding]; other site
164756006103	motif 1; other site
164756006104	motif 2; other site
164756006105	motif 3; other site
164756006106	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
164756006107	anticodon binding site; other site
164756006108	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
164756006109	nucleotide binding site/active site [active]
164756006110	HIT family signature motif; other site
164756006111	catalytic residue [active]
164756006112	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
164756006113	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
164756006114	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
164756006115	putative acyl-acceptor binding pocket; other site
164756006116	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756006117	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
164756006118	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
164756006119	nudix motif; other site
164756006120	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
164756006121	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
164756006122	active site
164756006123	multimer interface [polypeptide binding]; other site
164756006124	acyl-CoA thioesterase II; Region: tesB; TIGR00189
164756006125	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
164756006126	active site
164756006127	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
164756006128	catalytic triad [active]
164756006129	dimer interface [polypeptide binding]; other site
164756006130	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
164756006131	imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855
164756006132	predicted active site [active]
164756006133	catalytic triad [active]
164756006134	hypothetical protein; Validated; Region: PRK00110
164756006135	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
164756006136	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
164756006137	substrate binding pocket [chemical binding]; other site
164756006138	chain length determination region; other site
164756006139	substrate-Mg2+ binding site; other site
164756006140	catalytic residues [active]
164756006141	aspartate-rich region 1; other site
164756006142	active site lid residues [active]
164756006143	aspartate-rich region 2; other site
164756006144	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
164756006145	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
164756006146	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
164756006147	classical (c) SDRs; Region: SDR_c; cd05233
164756006148	NAD(P) binding site [chemical binding]; other site
164756006149	active site
164756006150	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
164756006151	classical (c) SDRs; Region: SDR_c; cd05233
164756006152	NAD(P) binding site [chemical binding]; other site
164756006153	active site
164756006154	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
164756006155	agmatinase; Region: agmatinase; TIGR01230
164756006156	oligomer interface [polypeptide binding]; other site
164756006157	putative active site [active]
164756006158	Mn binding site [ion binding]; other site
164756006159	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
164756006160	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
164756006161	active site
164756006162	catalytic site [active]
164756006163	Zn binding site [ion binding]; other site
164756006164	tetramer interface [polypeptide binding]; other site
164756006165	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756006166	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756006167	iron-sulfur cluster [ion binding]; other site
164756006168	[2Fe-2S] cluster binding site [ion binding]; other site
164756006169	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756006170	hydrophobic ligand binding site; other site
164756006171	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
164756006172	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
164756006173	FMN-binding pocket [chemical binding]; other site
164756006174	flavin binding motif; other site
164756006175	phosphate binding motif [ion binding]; other site
164756006176	beta-alpha-beta structure motif; other site
164756006177	NAD binding pocket [chemical binding]; other site
164756006178	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756006179	catalytic loop [active]
164756006180	iron binding site [ion binding]; other site
164756006181	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
164756006182	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
164756006183	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
164756006184	Mechanosensitive ion channel; Region: MS_channel; pfam00924
164756006185	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
164756006186	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
164756006187	active site
164756006188	putative DNA-binding cleft [nucleotide binding]; other site
164756006189	dimer interface [polypeptide binding]; other site
164756006190	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
164756006191	RuvA N terminal domain; Region: RuvA_N; pfam01330
164756006192	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
164756006193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756006194	Walker A motif; other site
164756006195	ATP binding site [chemical binding]; other site
164756006196	Walker B motif; other site
164756006197	arginine finger; other site
164756006198	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
164756006199	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
164756006200	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
164756006201	putative di-iron ligands [ion binding]; other site
164756006202	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
164756006203	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
164756006204	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
164756006205	FAD binding pocket [chemical binding]; other site
164756006206	FAD binding motif [chemical binding]; other site
164756006207	phosphate binding motif [ion binding]; other site
164756006208	beta-alpha-beta structure motif; other site
164756006209	NAD binding pocket [chemical binding]; other site
164756006210	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756006211	catalytic loop [active]
164756006212	iron binding site [ion binding]; other site
164756006213	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
164756006214	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756006215	acyl-activating enzyme (AAE) consensus motif; other site
164756006216	AMP binding site [chemical binding]; other site
164756006217	active site
164756006218	CoA binding site [chemical binding]; other site
164756006219	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
164756006220	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
164756006221	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
164756006222	putative NAD(P) binding site [chemical binding]; other site
164756006223	active site
164756006224	putative substrate binding site [chemical binding]; other site
164756006225	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
164756006226	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
164756006227	tetrameric interface [polypeptide binding]; other site
164756006228	NAD binding site [chemical binding]; other site
164756006229	catalytic residues [active]
164756006230	substrate binding site [chemical binding]; other site
164756006231	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
164756006232	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756006233	inhibitor-cofactor binding pocket; inhibition site
164756006234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756006235	catalytic residue [active]
164756006236	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
164756006237	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
164756006238	Protein export membrane protein; Region: SecD_SecF; cl14618
164756006239	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
164756006240	Protein export membrane protein; Region: SecD_SecF; pfam02355
164756006241	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
164756006242	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
164756006243	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756006244	active site
164756006245	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
164756006246	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
164756006247	Zn2+ binding site [ion binding]; other site
164756006248	Mg2+ binding site [ion binding]; other site
164756006249	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
164756006250	synthetase active site [active]
164756006251	NTP binding site [chemical binding]; other site
164756006252	metal binding site [ion binding]; metal-binding site
164756006253	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
164756006254	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
164756006255	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
164756006256	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
164756006257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
164756006258	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
164756006259	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
164756006260	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
164756006261	active site
164756006262	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
164756006263	active site
164756006264	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
164756006265	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
164756006266	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
164756006267	dimer interface [polypeptide binding]; other site
164756006268	motif 1; other site
164756006269	active site
164756006270	motif 2; other site
164756006271	motif 3; other site
164756006272	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
164756006273	anticodon binding site; other site
164756006274	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756006275	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
164756006276	putative NAD(P) binding site [chemical binding]; other site
164756006277	catalytic Zn binding site [ion binding]; other site
164756006278	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
164756006279	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
164756006280	Walker A/P-loop; other site
164756006281	ATP binding site [chemical binding]; other site
164756006282	Q-loop/lid; other site
164756006283	ABC transporter signature motif; other site
164756006284	Walker B; other site
164756006285	D-loop; other site
164756006286	H-loop/switch region; other site
164756006287	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
164756006288	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
164756006289	Walker A/P-loop; other site
164756006290	ATP binding site [chemical binding]; other site
164756006291	Q-loop/lid; other site
164756006292	ABC transporter signature motif; other site
164756006293	Walker B; other site
164756006294	D-loop; other site
164756006295	H-loop/switch region; other site
164756006296	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
164756006297	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
164756006298	TM-ABC transporter signature motif; other site
164756006299	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
164756006300	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
164756006301	TM-ABC transporter signature motif; other site
164756006302	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
164756006303	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
164756006304	putative ligand binding site [chemical binding]; other site
164756006305	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
164756006306	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
164756006307	PYR/PP interface [polypeptide binding]; other site
164756006308	dimer interface [polypeptide binding]; other site
164756006309	TPP binding site [chemical binding]; other site
164756006310	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
164756006311	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
164756006312	TPP-binding site; other site
164756006313	dimer interface [polypeptide binding]; other site
164756006314	Transcriptional regulator [Transcription]; Region: IclR; COG1414
164756006315	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
164756006316	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
164756006317	DNA-binding site [nucleotide binding]; DNA binding site
164756006318	RNA-binding motif; other site
164756006319	Radical SAM superfamily; Region: Radical_SAM; pfam04055
164756006320	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756006321	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756006322	active site
164756006323	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756006324	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756006325	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756006326	active site
164756006327	Amidohydrolase; Region: Amidohydro_2; pfam04909
164756006328	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756006329	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756006330	acyl-CoA thioesterase II; Region: tesB; TIGR00189
164756006331	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
164756006332	active site
164756006333	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
164756006334	catalytic triad [active]
164756006335	dimer interface [polypeptide binding]; other site
164756006336	DinB superfamily; Region: DinB_2; pfam12867
164756006337	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
164756006338	Predicted metalloprotease [General function prediction only]; Region: COG2321
164756006339	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
164756006340	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756006341	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
164756006342	substrate binding pocket [chemical binding]; other site
164756006343	catalytic triad [active]
164756006344	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
164756006345	putative hydrophobic ligand binding site [chemical binding]; other site
164756006346	protein interface [polypeptide binding]; other site
164756006347	gate; other site
164756006348	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
164756006349	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
164756006350	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
164756006351	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
164756006352	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
164756006353	dimer interface [polypeptide binding]; other site
164756006354	anticodon binding site; other site
164756006355	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
164756006356	homodimer interface [polypeptide binding]; other site
164756006357	motif 1; other site
164756006358	active site
164756006359	motif 2; other site
164756006360	GAD domain; Region: GAD; pfam02938
164756006361	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
164756006362	active site
164756006363	motif 3; other site
164756006364	Uncharacterized conserved protein [Function unknown]; Region: COG3349
164756006365	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756006366	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
164756006367	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
164756006368	substrate binding pocket [chemical binding]; other site
164756006369	chain length determination region; other site
164756006370	substrate-Mg2+ binding site; other site
164756006371	catalytic residues [active]
164756006372	aspartate-rich region 1; other site
164756006373	active site lid residues [active]
164756006374	aspartate-rich region 2; other site
164756006375	Predicted ATPase [General function prediction only]; Region: COG3899
164756006376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756006377	Walker A motif; other site
164756006378	ATP binding site [chemical binding]; other site
164756006379	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
164756006380	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
164756006381	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756006382	cyclase homology domain; Region: CHD; cd07302
164756006383	nucleotidyl binding site; other site
164756006384	metal binding site [ion binding]; metal-binding site
164756006385	dimer interface [polypeptide binding]; other site
164756006386	Domain of unknown function (DUF385); Region: DUF385; pfam04075
164756006387	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
164756006388	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
164756006389	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756006390	dimer interface [polypeptide binding]; other site
164756006391	active site
164756006392	Predicted transcriptional regulators [Transcription]; Region: COG1733
164756006393	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
164756006394	Domain of unknown function (DUF389); Region: DUF389; cl00781
164756006395	Domain of unknown function (DUF389); Region: DUF389; pfam04087
164756006396	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
164756006397	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
164756006398	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
164756006399	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
164756006400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
164756006401	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
164756006402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
164756006403	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
164756006404	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
164756006405	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
164756006406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
164756006407	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
164756006408	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
164756006409	recombination factor protein RarA; Reviewed; Region: PRK13342
164756006410	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756006411	Walker A motif; other site
164756006412	ATP binding site [chemical binding]; other site
164756006413	Walker B motif; other site
164756006414	arginine finger; other site
164756006415	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
164756006416	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756006417	dimerization interface [polypeptide binding]; other site
164756006418	putative DNA binding site [nucleotide binding]; other site
164756006419	putative Zn2+ binding site [ion binding]; other site
164756006420	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
164756006421	putative hydrophobic ligand binding site [chemical binding]; other site
164756006422	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
164756006423	dimer interface [polypeptide binding]; other site
164756006424	active site
164756006425	product binding site; other site
164756006426	malonyl-CoA binding site [chemical binding]; other site
164756006427	Phospholipid methyltransferase; Region: PEMT; cl17370
164756006428	MMPL family; Region: MMPL; pfam03176
164756006429	MMPL family; Region: MMPL; pfam03176
164756006430	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
164756006431	putative hydrophobic ligand binding site [chemical binding]; other site
164756006432	gas vesicle synthesis-like protein; Reviewed; Region: PRK09368
164756006433	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
164756006434	Gas vesicle protein G; Region: GvpG; pfam05120
164756006435	Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800
164756006436	Gas vesicle protein; Region: Gas_vesicle; pfam00741
164756006437	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
164756006438	Gas vesicle protein; Region: Gas_vesicle; pfam00741
164756006439	Gas vesicle protein K; Region: GvpK; pfam05121
164756006440	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
164756006441	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756006442	acyl-activating enzyme (AAE) consensus motif; other site
164756006443	AMP binding site [chemical binding]; other site
164756006444	active site
164756006445	CoA binding site [chemical binding]; other site
164756006446	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
164756006447	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
164756006448	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
164756006449	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
164756006450	motif 1; other site
164756006451	active site
164756006452	motif 2; other site
164756006453	motif 3; other site
164756006454	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
164756006455	DHHA1 domain; Region: DHHA1; pfam02272
164756006456	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
164756006457	YceG-like family; Region: YceG; pfam02618
164756006458	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
164756006459	dimerization interface [polypeptide binding]; other site
164756006460	shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809
164756006461	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
164756006462	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
164756006463	shikimate binding site; other site
164756006464	NAD(P) binding site [chemical binding]; other site
164756006465	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
164756006466	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
164756006467	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
164756006468	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
164756006469	NAD(P) binding site [chemical binding]; other site
164756006470	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
164756006471	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
164756006472	Tetramer interface [polypeptide binding]; other site
164756006473	active site
164756006474	FMN-binding site [chemical binding]; other site
164756006475	shikimate kinase; Reviewed; Region: aroK; PRK00131
164756006476	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
164756006477	ADP binding site [chemical binding]; other site
164756006478	magnesium binding site [ion binding]; other site
164756006479	putative shikimate binding site; other site
164756006480	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
164756006481	active site
164756006482	dimer interface [polypeptide binding]; other site
164756006483	metal binding site [ion binding]; metal-binding site
164756006484	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
164756006485	Dehydroquinase class II; Region: DHquinase_II; pfam01220
164756006486	trimer interface [polypeptide binding]; other site
164756006487	active site
164756006488	dimer interface [polypeptide binding]; other site
164756006489	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
164756006490	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
164756006491	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
164756006492	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
164756006493	active site
164756006494	elongation factor P; Validated; Region: PRK00529
164756006495	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
164756006496	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
164756006497	RNA binding site [nucleotide binding]; other site
164756006498	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
164756006499	RNA binding site [nucleotide binding]; other site
164756006500	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
164756006501	putative RNA binding site [nucleotide binding]; other site
164756006502	hypothetical protein; Provisional; Region: PRK07236
164756006503	hypothetical protein; Validated; Region: PRK05868
164756006504	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756006505	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756006506	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
164756006507	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756006508	active site
164756006509	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
164756006510	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
164756006511	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
164756006512	dihydroorotase; Validated; Region: pyrC; PRK09357
164756006513	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756006514	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
164756006515	active site
164756006516	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
164756006517	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
164756006518	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
164756006519	catalytic site [active]
164756006520	subunit interface [polypeptide binding]; other site
164756006521	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
164756006522	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
164756006523	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756006524	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
164756006525	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
164756006526	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756006527	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
164756006528	IMP binding site; other site
164756006529	dimer interface [polypeptide binding]; other site
164756006530	interdomain contacts; other site
164756006531	partial ornithine binding site; other site
164756006532	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
164756006533	active site
164756006534	dimer interface [polypeptide binding]; other site
164756006535	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
164756006536	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
164756006537	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
164756006538	catalytic site [active]
164756006539	G-X2-G-X-G-K; other site
164756006540	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
164756006541	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
164756006542	Flavoprotein; Region: Flavoprotein; pfam02441
164756006543	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
164756006544	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
164756006545	S-adenosylmethionine synthetase; Validated; Region: PRK05250
164756006546	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
164756006547	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
164756006548	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756006549	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756006550	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
164756006551	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756006552	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
164756006553	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
164756006554	putative NAD(P) binding site [chemical binding]; other site
164756006555	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756006556	Predicted membrane protein [Function unknown]; Region: COG3714
164756006557	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
164756006558	primosome assembly protein PriA; Provisional; Region: PRK14873
164756006559	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
164756006560	LemA family; Region: LemA; cl00742
164756006561	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
164756006562	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
164756006563	putative active site [active]
164756006564	substrate binding site [chemical binding]; other site
164756006565	putative cosubstrate binding site; other site
164756006566	catalytic site [active]
164756006567	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
164756006568	substrate binding site [chemical binding]; other site
164756006569	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
164756006570	putative RNA binding site [nucleotide binding]; other site
164756006571	16S rRNA methyltransferase B; Provisional; Region: PRK14902
164756006572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756006573	S-adenosylmethionine binding site [chemical binding]; other site
164756006574	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
164756006575	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
164756006576	substrate binding site [chemical binding]; other site
164756006577	hexamer interface [polypeptide binding]; other site
164756006578	metal binding site [ion binding]; metal-binding site
164756006579	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
164756006580	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
164756006581	catalytic motif [active]
164756006582	Zn binding site [ion binding]; other site
164756006583	RibD C-terminal domain; Region: RibD_C; pfam01872
164756006584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756006585	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756006586	putative substrate translocation pore; other site
164756006587	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
164756006588	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
164756006589	Lumazine binding domain; Region: Lum_binding; pfam00677
164756006590	Lumazine binding domain; Region: Lum_binding; pfam00677
164756006591	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
164756006592	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
164756006593	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
164756006594	dimerization interface [polypeptide binding]; other site
164756006595	active site
164756006596	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
164756006597	homopentamer interface [polypeptide binding]; other site
164756006598	active site
164756006599	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
164756006600	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756006601	Coenzyme A binding pocket [chemical binding]; other site
164756006602	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
164756006603	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
164756006604	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
164756006605	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
164756006606	GIY-YIG motif/motif A; other site
164756006607	active site
164756006608	catalytic site [active]
164756006609	putative DNA binding site [nucleotide binding]; other site
164756006610	metal binding site [ion binding]; metal-binding site
164756006611	UvrB/uvrC motif; Region: UVR; pfam02151
164756006612	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
164756006613	minor groove reading motif; other site
164756006614	Helix-hairpin-helix motif; Region: HHH; pfam00633
164756006615	helix-hairpin-helix signature motif; other site
164756006616	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
164756006617	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
164756006618	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
164756006619	phosphate binding site [ion binding]; other site
164756006620	putative substrate binding pocket [chemical binding]; other site
164756006621	dimer interface [polypeptide binding]; other site
164756006622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
164756006623	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
164756006624	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
164756006625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756006626	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756006627	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756006628	active site
164756006629	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756006630	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
164756006631	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756006632	substrate binding pocket [chemical binding]; other site
164756006633	membrane-bound complex binding site; other site
164756006634	hinge residues; other site
164756006635	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
164756006636	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
164756006637	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
164756006638	Phosphoglycerate kinase; Region: PGK; pfam00162
164756006639	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
164756006640	substrate binding site [chemical binding]; other site
164756006641	hinge regions; other site
164756006642	ADP binding site [chemical binding]; other site
164756006643	catalytic site [active]
164756006644	triosephosphate isomerase; Provisional; Region: PRK14567
164756006645	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
164756006646	substrate binding site [chemical binding]; other site
164756006647	dimer interface [polypeptide binding]; other site
164756006648	catalytic triad [active]
164756006649	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
164756006650	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
164756006651	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
164756006652	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
164756006653	putative active site [active]
164756006654	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
164756006655	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
164756006656	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
164756006657	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
164756006658	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
164756006659	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
164756006660	putative active site [active]
164756006661	transaldolase; Provisional; Region: PRK03903
164756006662	catalytic residue [active]
164756006663	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
164756006664	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
164756006665	TPP-binding site [chemical binding]; other site
164756006666	dimer interface [polypeptide binding]; other site
164756006667	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
164756006668	PYR/PP interface [polypeptide binding]; other site
164756006669	dimer interface [polypeptide binding]; other site
164756006670	TPP binding site [chemical binding]; other site
164756006671	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
164756006672	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
164756006673	UbiA prenyltransferase family; Region: UbiA; pfam01040
164756006674	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
164756006675	Winged helix-turn helix; Region: HTH_29; pfam13551
164756006676	Integrase core domain; Region: rve; pfam00665
164756006677	Integrase core domain; Region: rve_3; pfam13683
164756006678	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
164756006679	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756006680	Walker A/P-loop; other site
164756006681	ATP binding site [chemical binding]; other site
164756006682	Q-loop/lid; other site
164756006683	ABC transporter signature motif; other site
164756006684	Walker B; other site
164756006685	D-loop; other site
164756006686	H-loop/switch region; other site
164756006687	TOBE domain; Region: TOBE_2; pfam08402
164756006688	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
164756006689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756006690	dimer interface [polypeptide binding]; other site
164756006691	conserved gate region; other site
164756006692	putative PBP binding loops; other site
164756006693	ABC-ATPase subunit interface; other site
164756006694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756006695	dimer interface [polypeptide binding]; other site
164756006696	conserved gate region; other site
164756006697	putative PBP binding loops; other site
164756006698	ABC-ATPase subunit interface; other site
164756006699	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
164756006700	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
164756006701	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756006702	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756006703	NAD(P) binding site [chemical binding]; other site
164756006704	active site
164756006705	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
164756006706	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
164756006707	N- and C-terminal domain interface [polypeptide binding]; other site
164756006708	putative active site [active]
164756006709	MgATP binding site [chemical binding]; other site
164756006710	catalytic site [active]
164756006711	metal binding site [ion binding]; metal-binding site
164756006712	putative xylulose binding site [chemical binding]; other site
164756006713	putative homodimer interface [polypeptide binding]; other site
164756006714	BtpA family; Region: BtpA; cl00440
164756006715	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
164756006716	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
164756006717	active site
164756006718	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
164756006719	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
164756006720	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
164756006721	hypothetical protein; Provisional; Region: PRK09256
164756006722	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
164756006723	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
164756006724	NADP binding site [chemical binding]; other site
164756006725	dimer interface [polypeptide binding]; other site
164756006726	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
164756006727	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
164756006728	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756006729	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756006730	ABC-2 type transporter; Region: ABC2_membrane; cl17235
164756006731	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
164756006732	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
164756006733	Walker A/P-loop; other site
164756006734	ATP binding site [chemical binding]; other site
164756006735	Q-loop/lid; other site
164756006736	ABC transporter signature motif; other site
164756006737	Walker B; other site
164756006738	D-loop; other site
164756006739	H-loop/switch region; other site
164756006740	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
164756006741	Predicted transcriptional regulator [Transcription]; Region: COG2345
164756006742	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756006743	dimerization interface [polypeptide binding]; other site
164756006744	putative DNA binding site [nucleotide binding]; other site
164756006745	putative Zn2+ binding site [ion binding]; other site
164756006746	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
164756006747	FeS assembly protein SufB; Region: sufB; TIGR01980
164756006748	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
164756006749	FeS assembly protein SufD; Region: sufD; TIGR01981
164756006750	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
164756006751	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
164756006752	Walker A/P-loop; other site
164756006753	ATP binding site [chemical binding]; other site
164756006754	Q-loop/lid; other site
164756006755	ABC transporter signature motif; other site
164756006756	Walker B; other site
164756006757	D-loop; other site
164756006758	H-loop/switch region; other site
164756006759	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
164756006760	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
164756006761	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756006762	catalytic residue [active]
164756006763	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
164756006764	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
164756006765	trimerization site [polypeptide binding]; other site
164756006766	active site
164756006767	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
164756006768	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
164756006769	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
164756006770	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
164756006771	catalytic residues [active]
164756006772	enoyl-CoA hydratase; Provisional; Region: PRK05864
164756006773	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756006774	substrate binding site [chemical binding]; other site
164756006775	oxyanion hole (OAH) forming residues; other site
164756006776	trimer interface [polypeptide binding]; other site
164756006777	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
164756006778	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756006779	Walker A/P-loop; other site
164756006780	ATP binding site [chemical binding]; other site
164756006781	Q-loop/lid; other site
164756006782	ABC transporter signature motif; other site
164756006783	Walker B; other site
164756006784	D-loop; other site
164756006785	H-loop/switch region; other site
164756006786	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756006787	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756006788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756006789	aconitate hydratase; Validated; Region: PRK09277
164756006790	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
164756006791	substrate binding site [chemical binding]; other site
164756006792	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
164756006793	ligand binding site [chemical binding]; other site
164756006794	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
164756006795	substrate binding site [chemical binding]; other site
164756006796	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
164756006797	NlpC/P60 family; Region: NLPC_P60; pfam00877
164756006798	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
164756006799	NlpC/P60 family; Region: NLPC_P60; pfam00877
164756006800	MoxR-like ATPases [General function prediction only]; Region: COG0714
164756006801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756006802	Walker A motif; other site
164756006803	ATP binding site [chemical binding]; other site
164756006804	Walker B motif; other site
164756006805	arginine finger; other site
164756006806	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
164756006807	Protein of unknown function DUF58; Region: DUF58; pfam01882
164756006808	hypothetical protein; Provisional; Region: PRK13685
164756006809	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
164756006810	metal ion-dependent adhesion site (MIDAS); other site
164756006811	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
164756006812	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
164756006813	NAD(P) binding site [chemical binding]; other site
164756006814	homotetramer interface [polypeptide binding]; other site
164756006815	homodimer interface [polypeptide binding]; other site
164756006816	active site
164756006817	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
164756006818	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
164756006819	NAD binding site [chemical binding]; other site
164756006820	homotetramer interface [polypeptide binding]; other site
164756006821	homodimer interface [polypeptide binding]; other site
164756006822	substrate binding site [chemical binding]; other site
164756006823	active site
164756006824	ferrochelatase; Reviewed; Region: hemH; PRK00035
164756006825	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
164756006826	C-terminal domain interface [polypeptide binding]; other site
164756006827	active site
164756006828	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
164756006829	active site
164756006830	N-terminal domain interface [polypeptide binding]; other site
164756006831	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
164756006832	hydroxyglutarate oxidase; Provisional; Region: PRK11728
164756006833	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
164756006834	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
164756006835	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
164756006836	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
164756006837	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
164756006838	hydroxyglutarate oxidase; Provisional; Region: PRK11728
164756006839	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756006840	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
164756006841	[2Fe-2S] cluster binding site [ion binding]; other site
164756006842	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756006843	hydrophobic ligand binding site; other site
164756006844	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
164756006845	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756006846	tetramerization interface [polypeptide binding]; other site
164756006847	NAD(P) binding site [chemical binding]; other site
164756006848	catalytic residues [active]
164756006849	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
164756006850	choline dehydrogenase; Validated; Region: PRK02106
164756006851	lycopene cyclase; Region: lycopene_cycl; TIGR01789
164756006852	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
164756006853	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
164756006854	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
164756006855	ligand binding site [chemical binding]; other site
164756006856	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
164756006857	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
164756006858	metal binding triad; other site
164756006859	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
164756006860	Transcriptional regulator [Transcription]; Region: IclR; COG1414
164756006861	Bacterial transcriptional regulator; Region: IclR; pfam01614
164756006862	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
164756006863	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756006864	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756006865	active site
164756006866	Predicted transcriptional regulator [Transcription]; Region: COG2378
164756006867	WYL domain; Region: WYL; pfam13280
164756006868	Predicted transcriptional regulator [Transcription]; Region: COG2378
164756006869	WYL domain; Region: WYL; pfam13280
164756006870	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
164756006871	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
164756006872	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
164756006873	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
164756006874	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756006875	ATP binding site [chemical binding]; other site
164756006876	putative Mg++ binding site [ion binding]; other site
164756006877	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756006878	nucleotide binding region [chemical binding]; other site
164756006879	ATP-binding site [chemical binding]; other site
164756006880	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
164756006881	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
164756006882	5'-3' exonuclease; Region: 53EXOc; smart00475
164756006883	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
164756006884	active site
164756006885	metal binding site 1 [ion binding]; metal-binding site
164756006886	putative 5' ssDNA interaction site; other site
164756006887	metal binding site 3; metal-binding site
164756006888	metal binding site 2 [ion binding]; metal-binding site
164756006889	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
164756006890	putative DNA binding site [nucleotide binding]; other site
164756006891	putative metal binding site [ion binding]; other site
164756006892	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
164756006893	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
164756006894	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
164756006895	active site
164756006896	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
164756006897	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
164756006898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756006899	NAD(P) binding site [chemical binding]; other site
164756006900	active site
164756006901	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
164756006902	active site
164756006903	SAM binding site [chemical binding]; other site
164756006904	putative homodimer interface [polypeptide binding]; other site
164756006905	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
164756006906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756006907	S-adenosylmethionine binding site [chemical binding]; other site
164756006908	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
164756006909	active site
164756006910	SAM binding site [chemical binding]; other site
164756006911	homodimer interface [polypeptide binding]; other site
164756006912	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
164756006913	Phosphotransferase enzyme family; Region: APH; pfam01636
164756006914	Ecdysteroid kinase; Region: EcKinase; cl17738
164756006915	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
164756006916	active site
164756006917	SAM binding site [chemical binding]; other site
164756006918	homodimer interface [polypeptide binding]; other site
164756006919	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
164756006920	active site
164756006921	SAM binding site [chemical binding]; other site
164756006922	homodimer interface [polypeptide binding]; other site
164756006923	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
164756006924	Precorrin-8X methylmutase; Region: CbiC; pfam02570
164756006925	precorrin-3B synthase; Region: CobG; TIGR02435
164756006926	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
164756006927	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
164756006928	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
164756006929	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
164756006930	ligand binding site [chemical binding]; other site
164756006931	flexible hinge region; other site
164756006932	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
164756006933	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
164756006934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756006935	ABC-ATPase subunit interface; other site
164756006936	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
164756006937	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
164756006938	Walker A/P-loop; other site
164756006939	ATP binding site [chemical binding]; other site
164756006940	Q-loop/lid; other site
164756006941	ABC transporter signature motif; other site
164756006942	Walker B; other site
164756006943	D-loop; other site
164756006944	H-loop/switch region; other site
164756006945	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
164756006946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756006947	putative PBP binding loops; other site
164756006948	dimer interface [polypeptide binding]; other site
164756006949	ABC-ATPase subunit interface; other site
164756006950	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
164756006951	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
164756006952	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
164756006953	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
164756006954	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
164756006955	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
164756006956	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
164756006957	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
164756006958	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
164756006959	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
164756006960	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756006961	active site
164756006962	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
164756006963	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
164756006964	putative active site [active]
164756006965	catalytic triad [active]
164756006966	putative dimer interface [polypeptide binding]; other site
164756006967	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
164756006968	Ligand binding site; other site
164756006969	Putative Catalytic site; other site
164756006970	DXD motif; other site
164756006971	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
164756006972	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
164756006973	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756006974	ATP binding site [chemical binding]; other site
164756006975	putative Mg++ binding site [ion binding]; other site
164756006976	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756006977	nucleotide binding region [chemical binding]; other site
164756006978	ATP-binding site [chemical binding]; other site
164756006979	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756006980	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756006981	DNA binding site [nucleotide binding]
164756006982	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756006983	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
164756006984	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756006985	substrate binding pocket [chemical binding]; other site
164756006986	catalytic triad [active]
164756006987	Ecdysteroid kinase; Region: EcKinase; cl17738
164756006988	Phosphotransferase enzyme family; Region: APH; pfam01636
164756006989	hypothetical protein; Provisional; Region: PRK02237
164756006990	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
164756006991	RDD family; Region: RDD; pfam06271
164756006992	Predicted membrane protein [Function unknown]; Region: COG2259
164756006993	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756006994	D-xylulose kinase; Region: XylB; TIGR01312
164756006995	nucleotide binding site [chemical binding]; other site
164756006996	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756006997	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756006998	active site
164756006999	Transcriptional regulators [Transcription]; Region: GntR; COG1802
164756007000	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756007001	DNA-binding site [nucleotide binding]; DNA binding site
164756007002	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
164756007003	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
164756007004	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
164756007005	active site
164756007006	non-prolyl cis peptide bond; other site
164756007007	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756007008	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
164756007009	active site residue [active]
164756007010	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
164756007011	active site residue [active]
164756007012	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
164756007013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756007014	dimer interface [polypeptide binding]; other site
164756007015	conserved gate region; other site
164756007016	putative PBP binding loops; other site
164756007017	ABC-ATPase subunit interface; other site
164756007018	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
164756007019	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
164756007020	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
164756007021	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
164756007022	Walker A/P-loop; other site
164756007023	ATP binding site [chemical binding]; other site
164756007024	Q-loop/lid; other site
164756007025	ABC transporter signature motif; other site
164756007026	Walker B; other site
164756007027	D-loop; other site
164756007028	H-loop/switch region; other site
164756007029	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
164756007030	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
164756007031	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
164756007032	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
164756007033	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
164756007034	N- and C-terminal domain interface [polypeptide binding]; other site
164756007035	putative active site [active]
164756007036	MgATP binding site [chemical binding]; other site
164756007037	catalytic site [active]
164756007038	metal binding site [ion binding]; metal-binding site
164756007039	putative xylulose binding site [chemical binding]; other site
164756007040	putative homodimer interface [polypeptide binding]; other site
164756007041	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
164756007042	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756007043	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756007044	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756007045	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756007046	Cytochrome P450; Region: p450; cl12078
164756007047	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756007048	mce related protein; Region: MCE; pfam02470
164756007049	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756007050	Amidohydrolase; Region: Amidohydro_2; pfam04909
164756007051	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756007052	short chain dehydrogenase; Provisional; Region: PRK07791
164756007053	NAD(P) binding site [chemical binding]; other site
164756007054	active site
164756007055	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756007056	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756007057	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
164756007058	metal ion-dependent adhesion site (MIDAS); other site
164756007059	MoxR-like ATPases [General function prediction only]; Region: COG0714
164756007060	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
164756007061	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
164756007062	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
164756007063	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
164756007064	ligand binding site [chemical binding]; other site
164756007065	short chain dehydrogenase; Provisional; Region: PRK06179
164756007066	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
164756007067	NADP binding site [chemical binding]; other site
164756007068	active site
164756007069	steroid binding site; other site
164756007070	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
164756007071	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
164756007072	NAD binding site [chemical binding]; other site
164756007073	catalytic residues [active]
164756007074	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756007075	Cytochrome P450; Region: p450; cl12078
164756007076	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756007077	Cytochrome P450; Region: p450; cl12078
164756007078	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756007079	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756007080	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
164756007081	Winged helix-turn helix; Region: HTH_29; pfam13551
164756007082	Integrase core domain; Region: rve; pfam00665
164756007083	Integrase core domain; Region: rve_3; pfam13683
164756007084	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
164756007085	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756007086	putative acyl-acceptor binding pocket; other site
164756007087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007089	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007091	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756007092	classical (c) SDRs; Region: SDR_c; cd05233
164756007093	NAD(P) binding site [chemical binding]; other site
164756007094	active site
164756007095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007096	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
164756007097	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756007098	Cytochrome P450; Region: p450; cl12078
164756007099	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
164756007100	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756007101	DNA binding residues [nucleotide binding]
164756007102	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
164756007103	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756007104	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
164756007105	NAD(P) binding site [chemical binding]; other site
164756007106	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
164756007107	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
164756007108	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
164756007109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756007110	dimer interface [polypeptide binding]; other site
164756007111	conserved gate region; other site
164756007112	putative PBP binding loops; other site
164756007113	ABC-ATPase subunit interface; other site
164756007114	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
164756007115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756007116	dimer interface [polypeptide binding]; other site
164756007117	conserved gate region; other site
164756007118	putative PBP binding loops; other site
164756007119	ABC-ATPase subunit interface; other site
164756007120	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
164756007121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007122	Walker A/P-loop; other site
164756007123	ATP binding site [chemical binding]; other site
164756007124	Q-loop/lid; other site
164756007125	ABC transporter signature motif; other site
164756007126	Walker B; other site
164756007127	D-loop; other site
164756007128	H-loop/switch region; other site
164756007129	TOBE domain; Region: TOBE_2; pfam08402
164756007130	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
164756007131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007132	Walker A/P-loop; other site
164756007133	ATP binding site [chemical binding]; other site
164756007134	Q-loop/lid; other site
164756007135	ABC transporter signature motif; other site
164756007136	Walker B; other site
164756007137	D-loop; other site
164756007138	H-loop/switch region; other site
164756007139	dihydroxyacetone kinase; Provisional; Region: PRK14479
164756007140	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
164756007141	DAK2 domain; Region: Dak2; pfam02734
164756007142	ribose 5-phosphate isomerase; Region: RPI_actino; TIGR02133
164756007143	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
164756007144	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
164756007145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756007146	dimer interface [polypeptide binding]; other site
164756007147	conserved gate region; other site
164756007148	putative PBP binding loops; other site
164756007149	ABC-ATPase subunit interface; other site
164756007150	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
164756007151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756007152	dimer interface [polypeptide binding]; other site
164756007153	conserved gate region; other site
164756007154	putative PBP binding loops; other site
164756007155	ABC-ATPase subunit interface; other site
164756007156	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
164756007157	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
164756007158	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
164756007159	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007160	Walker A/P-loop; other site
164756007161	ATP binding site [chemical binding]; other site
164756007162	Q-loop/lid; other site
164756007163	ABC transporter signature motif; other site
164756007164	Walker B; other site
164756007165	D-loop; other site
164756007166	H-loop/switch region; other site
164756007167	TOBE domain; Region: TOBE_2; pfam08402
164756007168	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756007169	hydrophobic ligand binding site; other site
164756007170	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
164756007171	TspO/MBR family; Region: TspO_MBR; pfam03073
164756007172	tartrate dehydrogenase; Provisional; Region: PRK08194
164756007173	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
164756007174	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
164756007175	tartrate dehydrogenase; Provisional; Region: PRK08194
164756007176	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
164756007177	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
164756007178	transmembrane helices; other site
164756007179	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756007180	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756007181	putative DNA binding site [nucleotide binding]; other site
164756007182	putative Zn2+ binding site [ion binding]; other site
164756007183	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
164756007184	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
164756007185	Ferredoxin [Energy production and conversion]; Region: COG1146
164756007186	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
164756007187	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
164756007188	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
164756007189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007190	Walker A/P-loop; other site
164756007191	ATP binding site [chemical binding]; other site
164756007192	Q-loop/lid; other site
164756007193	ABC transporter signature motif; other site
164756007194	Walker B; other site
164756007195	D-loop; other site
164756007196	H-loop/switch region; other site
164756007197	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
164756007198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756007199	dimer interface [polypeptide binding]; other site
164756007200	conserved gate region; other site
164756007201	putative PBP binding loops; other site
164756007202	ABC-ATPase subunit interface; other site
164756007203	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
164756007204	substrate binding pocket [chemical binding]; other site
164756007205	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
164756007206	membrane-bound complex binding site; other site
164756007207	hinge residues; other site
164756007208	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
164756007209	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
164756007210	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
164756007211	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756007212	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
164756007213	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
164756007214	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
164756007215	active site 1 [active]
164756007216	dimer interface [polypeptide binding]; other site
164756007217	hexamer interface [polypeptide binding]; other site
164756007218	active site 2 [active]
164756007219	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
164756007220	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
164756007221	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756007222	catalytic residue [active]
164756007223	Transposase; Region: HTH_Tnp_1; cl17663
164756007224	putative transposase OrfB; Reviewed; Region: PHA02517
164756007225	HTH-like domain; Region: HTH_21; pfam13276
164756007226	Integrase core domain; Region: rve; pfam00665
164756007227	Integrase core domain; Region: rve_3; cl15866
164756007228	HTH-like domain; Region: HTH_21; pfam13276
164756007229	Integrase core domain; Region: rve; pfam00665
164756007230	Integrase core domain; Region: rve_3; pfam13683
164756007231	AAA domain; Region: AAA_23; pfam13476
164756007232	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007233	ABC transporter signature motif; other site
164756007234	Walker B; other site
164756007235	D-loop; other site
164756007236	H-loop/switch region; other site
164756007237	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
164756007238	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
164756007239	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
164756007240	active site
164756007241	DNA binding site [nucleotide binding]
164756007242	Int/Topo IB signature motif; other site
164756007243	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
164756007244	YaeQ protein; Region: YaeQ; pfam07152
164756007245	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
164756007246	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756007247	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
164756007248	Flavin binding site [chemical binding]; other site
164756007249	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
164756007250	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
164756007251	AMP-binding domain protein; Validated; Region: PRK07529
164756007252	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756007253	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
164756007254	acyl-activating enzyme (AAE) consensus motif; other site
164756007255	putative AMP binding site [chemical binding]; other site
164756007256	putative active site [active]
164756007257	putative CoA binding site [chemical binding]; other site
164756007258	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756007259	CoenzymeA binding site [chemical binding]; other site
164756007260	subunit interaction site [polypeptide binding]; other site
164756007261	PHB binding site; other site
164756007262	Transcriptional regulator [Transcription]; Region: LysR; COG0583
164756007263	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756007264	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
164756007265	putative substrate binding pocket [chemical binding]; other site
164756007266	dimerization interface [polypeptide binding]; other site
164756007267	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
164756007268	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
164756007269	tetramer interface [polypeptide binding]; other site
164756007270	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
164756007271	active site
164756007272	metal binding site [ion binding]; metal-binding site
164756007273	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
164756007274	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
164756007275	NAD binding site [chemical binding]; other site
164756007276	catalytic residues [active]
164756007277	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
164756007278	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
164756007279	dimer interface [polypeptide binding]; other site
164756007280	active site
164756007281	catalytic residue [active]
164756007282	hypothetical protein; Provisional; Region: PRK12764
164756007283	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
164756007284	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
164756007285	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
164756007286	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
164756007287	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
164756007288	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
164756007289	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
164756007290	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756007291	active site
164756007292	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
164756007293	short chain dehydrogenase; Provisional; Region: PRK06180
164756007294	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
164756007295	NADP binding site [chemical binding]; other site
164756007296	active site
164756007297	steroid binding site; other site
164756007298	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
164756007299	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756007300	DNA binding residues [nucleotide binding]
164756007301	putative dimer interface [polypeptide binding]; other site
164756007302	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
164756007303	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756007304	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756007305	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
164756007306	salt bridge; other site
164756007307	non-specific DNA binding site [nucleotide binding]; other site
164756007308	sequence-specific DNA binding site [nucleotide binding]; other site
164756007309	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
164756007310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756007311	NAD(P) binding site [chemical binding]; other site
164756007312	active site
164756007313	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007314	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007315	aldose dehydrogenase; Validated; Region: PRK06398
164756007316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756007317	NAD(P) binding site [chemical binding]; other site
164756007318	active site
164756007319	Predicted transcriptional regulator [Transcription]; Region: COG2378
164756007320	HTH domain; Region: HTH_11; pfam08279
164756007321	WYL domain; Region: WYL; pfam13280
164756007322	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756007323	choline dehydrogenase; Validated; Region: PRK02106
164756007324	lycopene cyclase; Region: lycopene_cycl; TIGR01789
164756007325	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
164756007326	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
164756007327	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756007328	Domain of unknown function (DUF385); Region: DUF385; pfam04075
164756007329	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
164756007330	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
164756007331	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
164756007332	NIPSNAP; Region: NIPSNAP; pfam07978
164756007333	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007334	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007335	WHG domain; Region: WHG; pfam13305
164756007336	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756007337	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
164756007338	RibD C-terminal domain; Region: RibD_C; cl17279
164756007339	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756007340	Predicted membrane protein [Function unknown]; Region: COG2323
164756007341	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
164756007342	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756007343	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
164756007344	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756007345	DNA binding residues [nucleotide binding]
164756007346	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756007347	MarR family; Region: MarR; pfam01047
164756007348	Protein of unknown function (DUF461); Region: DUF461; cl01071
164756007349	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
164756007350	Predicted membrane protein [Function unknown]; Region: COG4325
164756007351	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
164756007352	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
164756007353	dimerization interface [polypeptide binding]; other site
164756007354	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007355	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007356	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
164756007357	classical (c) SDRs; Region: SDR_c; cd05233
164756007358	NAD(P) binding site [chemical binding]; other site
164756007359	active site
164756007360	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
164756007361	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
164756007362	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
164756007363	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756007364	classical (c) SDRs; Region: SDR_c; cd05233
164756007365	NAD(P) binding site [chemical binding]; other site
164756007366	active site
164756007367	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
164756007368	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
164756007369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
164756007370	AAA domain; Region: AAA_33; pfam13671
164756007371	hypothetical protein; Provisional; Region: PRK06834
164756007372	TrkA-N domain; Region: TrkA_N; pfam02254
164756007373	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756007374	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
164756007375	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
164756007376	active site
164756007377	catalytic tetrad [active]
164756007378	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
164756007379	RNA binding surface [nucleotide binding]; other site
164756007380	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756007381	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756007382	substrate binding site [chemical binding]; other site
164756007383	oxyanion hole (OAH) forming residues; other site
164756007384	trimer interface [polypeptide binding]; other site
164756007385	spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886
164756007386	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
164756007387	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756007388	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756007389	acyl-activating enzyme (AAE) consensus motif; other site
164756007390	acyl-activating enzyme (AAE) consensus motif; other site
164756007391	AMP binding site [chemical binding]; other site
164756007392	active site
164756007393	CoA binding site [chemical binding]; other site
164756007394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
164756007395	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007396	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007397	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
164756007398	NlpC/P60 family; Region: NLPC_P60; pfam00877
164756007399	Prostaglandin dehydrogenases; Region: PGDH; cd05288
164756007400	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
164756007401	NAD(P) binding site [chemical binding]; other site
164756007402	substrate binding site [chemical binding]; other site
164756007403	dimer interface [polypeptide binding]; other site
164756007404	MOSC domain; Region: MOSC; pfam03473
164756007405	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
164756007406	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
164756007407	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
164756007408	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756007409	hydrophobic ligand binding site; other site
164756007410	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
164756007411	metal binding site 2 [ion binding]; metal-binding site
164756007412	putative DNA binding helix; other site
164756007413	metal binding site 1 [ion binding]; metal-binding site
164756007414	dimer interface [polypeptide binding]; other site
164756007415	structural Zn2+ binding site [ion binding]; other site
164756007416	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
164756007417	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
164756007418	heme binding site [chemical binding]; other site
164756007419	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
164756007420	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
164756007421	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
164756007422	active site
164756007423	catalytic triad [active]
164756007424	oxyanion hole [active]
164756007425	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756007426	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
164756007427	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
164756007428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756007429	active site
164756007430	phosphorylation site [posttranslational modification]
164756007431	intermolecular recognition site; other site
164756007432	dimerization interface [polypeptide binding]; other site
164756007433	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
164756007434	CHASE3 domain; Region: CHASE3; pfam05227
164756007435	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756007436	dimerization interface [polypeptide binding]; other site
164756007437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756007438	dimer interface [polypeptide binding]; other site
164756007439	phosphorylation site [posttranslational modification]
164756007440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756007441	ATP binding site [chemical binding]; other site
164756007442	Mg2+ binding site [ion binding]; other site
164756007443	G-X-G motif; other site
164756007444	Response regulator receiver domain; Region: Response_reg; pfam00072
164756007445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756007446	active site
164756007447	phosphorylation site [posttranslational modification]
164756007448	intermolecular recognition site; other site
164756007449	dimerization interface [polypeptide binding]; other site
164756007450	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
164756007451	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756007452	dimerization interface [polypeptide binding]; other site
164756007453	putative DNA binding site [nucleotide binding]; other site
164756007454	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756007455	putative Zn2+ binding site [ion binding]; other site
164756007456	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
164756007457	putative hydrophobic ligand binding site [chemical binding]; other site
164756007458	NlpC/P60 family; Region: NLPC_P60; cl17555
164756007459	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
164756007460	Uncharacterized conserved protein [Function unknown]; Region: COG3379
164756007461	hypothetical protein; Validated; Region: PRK02101
164756007462	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756007463	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756007464	Amidohydrolase; Region: Amidohydro_2; pfam04909
164756007465	Helix-turn-helix domain; Region: HTH_18; pfam12833
164756007466	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756007467	hypothetical protein; Provisional; Region: PRK01346
164756007468	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
164756007469	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
164756007470	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756007471	catalytic residue [active]
164756007472	Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949
164756007473	putative active site [active]
164756007474	catalytic residue [active]
164756007475	Amidase; Region: Amidase; cl11426
164756007476	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
164756007477	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756007478	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
164756007479	competence damage-inducible protein A; Provisional; Region: PRK00549
164756007480	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
164756007481	putative MPT binding site; other site
164756007482	Competence-damaged protein; Region: CinA; pfam02464
164756007483	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756007484	Biofilm formation and stress response factor; Region: BsmA; pfam10014
164756007485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756007486	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756007487	NAD(P) binding site [chemical binding]; other site
164756007488	active site
164756007489	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756007490	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756007491	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
164756007492	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756007493	anti sigma factor interaction site; other site
164756007494	regulatory phosphorylation site [posttranslational modification]; other site
164756007495	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
164756007496	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
164756007497	Nitronate monooxygenase; Region: NMO; pfam03060
164756007498	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
164756007499	FMN binding site [chemical binding]; other site
164756007500	substrate binding site [chemical binding]; other site
164756007501	putative catalytic residue [active]
164756007502	Ferredoxin [Energy production and conversion]; Region: COG1146
164756007503	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007505	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
164756007506	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756007507	molybdopterin cofactor binding site; other site
164756007508	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756007509	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
164756007510	putative molybdopterin cofactor binding site; other site
164756007511	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756007512	Cytochrome P450; Region: p450; cl12078
164756007513	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
164756007514	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756007515	non-specific DNA binding site [nucleotide binding]; other site
164756007516	salt bridge; other site
164756007517	sequence-specific DNA binding site [nucleotide binding]; other site
164756007518	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
164756007519	Transcriptional regulators [Transcription]; Region: FadR; COG2186
164756007520	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756007521	DNA-binding site [nucleotide binding]; DNA binding site
164756007522	FCD domain; Region: FCD; cl11656
164756007523	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
164756007524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
164756007525	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
164756007526	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
164756007527	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
164756007528	hypothetical protein; Provisional; Region: PRK06815
164756007529	tetramer interface [polypeptide binding]; other site
164756007530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756007531	catalytic residue [active]
164756007532	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
164756007533	active site
164756007534	agmatinase; Region: agmatinase; TIGR01230
164756007535	Agmatinase-like family; Region: Agmatinase-like; cd09990
164756007536	active site
164756007537	oligomer interface [polypeptide binding]; other site
164756007538	Mn binding site [ion binding]; other site
164756007539	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
164756007540	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756007541	S-adenosylmethionine binding site [chemical binding]; other site
164756007542	chorismate mutase; Provisional; Region: PRK09269
164756007543	Chorismate mutase type II; Region: CM_2; cl00693
164756007544	short chain dehydrogenase; Provisional; Region: PRK08267
164756007545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756007546	NAD(P) binding site [chemical binding]; other site
164756007547	active site
164756007548	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756007549	hydrophobic ligand binding site; other site
164756007550	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756007551	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756007552	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756007553	Cytochrome P450; Region: p450; cl12078
164756007554	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
164756007555	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756007556	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007557	Predicted RNA-binding proteins [General function prediction only]; Region: PelA; COG1537
164756007558	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
164756007559	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756007560	motif II; other site
164756007561	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756007562	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
164756007563	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756007564	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756007565	active site
164756007566	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
164756007567	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756007568	short chain dehydrogenase; Provisional; Region: PRK08303
164756007569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756007570	NAD(P) binding site [chemical binding]; other site
164756007571	active site
164756007572	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
164756007573	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756007574	active site
164756007575	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756007576	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756007577	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
164756007578	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756007579	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
164756007580	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756007581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756007582	putative substrate translocation pore; other site
164756007583	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756007584	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
164756007585	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
164756007586	heme binding site [chemical binding]; other site
164756007587	ferroxidase pore; other site
164756007588	ferroxidase diiron center [ion binding]; other site
164756007589	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
164756007590	enoyl-CoA hydratase; Provisional; Region: PRK06688
164756007591	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756007592	substrate binding site [chemical binding]; other site
164756007593	oxyanion hole (OAH) forming residues; other site
164756007594	trimer interface [polypeptide binding]; other site
164756007595	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
164756007596	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756007597	CoenzymeA binding site [chemical binding]; other site
164756007598	subunit interaction site [polypeptide binding]; other site
164756007599	PHB binding site; other site
164756007600	Amidase; Region: Amidase; cl11426
164756007601	Isochorismatase family; Region: Isochorismatase; pfam00857
164756007602	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
164756007603	catalytic triad [active]
164756007604	conserved cis-peptide bond; other site
164756007605	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
164756007606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756007607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
164756007608	TPR motif; other site
164756007609	TPR repeat; Region: TPR_11; pfam13414
164756007610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
164756007611	binding surface
164756007612	TPR motif; other site
164756007613	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
164756007614	nucleoside/Zn binding site; other site
164756007615	dimer interface [polypeptide binding]; other site
164756007616	catalytic motif [active]
164756007617	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
164756007618	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
164756007619	active site
164756007620	catalytic site [active]
164756007621	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
164756007622	Putative esterase; Region: Esterase; pfam00756
164756007623	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
164756007624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756007625	Walker A motif; other site
164756007626	ATP binding site [chemical binding]; other site
164756007627	Walker B motif; other site
164756007628	arginine finger; other site
164756007629	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
164756007630	TfoX N-terminal domain; Region: TfoX_N; cl17592
164756007631	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
164756007632	minor groove reading motif; other site
164756007633	helix-hairpin-helix signature motif; other site
164756007634	Protein of unknown function DUF72; Region: DUF72; pfam01904
164756007635	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
164756007636	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
164756007637	putative ligand binding site [chemical binding]; other site
164756007638	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
164756007639	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
164756007640	putative ligand binding site [chemical binding]; other site
164756007641	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
164756007642	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
164756007643	TM-ABC transporter signature motif; other site
164756007644	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
164756007645	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
164756007646	Walker A/P-loop; other site
164756007647	ATP binding site [chemical binding]; other site
164756007648	Q-loop/lid; other site
164756007649	ABC transporter signature motif; other site
164756007650	Walker B; other site
164756007651	D-loop; other site
164756007652	H-loop/switch region; other site
164756007653	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
164756007654	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
164756007655	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756007656	NAD(P) binding site [chemical binding]; other site
164756007657	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756007658	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
164756007659	NAD(P) binding site [chemical binding]; other site
164756007660	active site
164756007661	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756007662	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
164756007663	inhibitor binding site; inhibition site
164756007664	catalytic Zn binding site [ion binding]; other site
164756007665	structural Zn binding site [ion binding]; other site
164756007666	NADP binding site [chemical binding]; other site
164756007667	tetramer interface [polypeptide binding]; other site
164756007668	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
164756007669	phosphate binding site [ion binding]; other site
164756007670	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
164756007671	N- and C-terminal domain interface [polypeptide binding]; other site
164756007672	active site
164756007673	MgATP binding site [chemical binding]; other site
164756007674	catalytic site [active]
164756007675	metal binding site [ion binding]; metal-binding site
164756007676	xylulose binding site [chemical binding]; other site
164756007677	putative homodimer interface [polypeptide binding]; other site
164756007678	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
164756007679	putative active site [active]
164756007680	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
164756007681	Homeodomain-like domain; Region: HTH_23; cl17451
164756007682	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
164756007683	short chain dehydrogenase; Provisional; Region: PRK06841
164756007684	classical (c) SDRs; Region: SDR_c; cd05233
164756007685	NAD(P) binding site [chemical binding]; other site
164756007686	active site
164756007687	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
164756007688	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756007689	active site
164756007690	putative phosphoketolase; Provisional; Region: PRK05261
164756007691	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
164756007692	TPP-binding site; other site
164756007693	XFP C-terminal domain; Region: XFP_C; pfam09363
164756007694	CAAX protease self-immunity; Region: Abi; pfam02517
164756007695	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
164756007696	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
164756007697	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007698	Walker A/P-loop; other site
164756007699	ATP binding site [chemical binding]; other site
164756007700	Q-loop/lid; other site
164756007701	ABC transporter signature motif; other site
164756007702	Walker B; other site
164756007703	D-loop; other site
164756007704	H-loop/switch region; other site
164756007705	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
164756007706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756007707	putative PBP binding loops; other site
164756007708	ABC-ATPase subunit interface; other site
164756007709	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
164756007710	classical (c) SDRs; Region: SDR_c; cd05233
164756007711	NAD(P) binding site [chemical binding]; other site
164756007712	active site
164756007713	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756007714	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
164756007715	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
164756007716	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756007717	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756007718	UreD urease accessory protein; Region: UreD; cl00530
164756007719	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756007720	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
164756007721	urease subunit alpha; Reviewed; Region: ureC; PRK13206
164756007722	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
164756007723	subunit interactions [polypeptide binding]; other site
164756007724	active site
164756007725	flap region; other site
164756007726	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
164756007727	gamma-beta subunit interface [polypeptide binding]; other site
164756007728	alpha-beta subunit interface [polypeptide binding]; other site
164756007729	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
164756007730	alpha-gamma subunit interface [polypeptide binding]; other site
164756007731	beta-gamma subunit interface [polypeptide binding]; other site
164756007732	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756007733	CoenzymeA binding site [chemical binding]; other site
164756007734	subunit interaction site [polypeptide binding]; other site
164756007735	PHB binding site; other site
164756007736	Predicted transcriptional regulator [Transcription]; Region: COG3682
164756007737	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
164756007738	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756007739	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
164756007740	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
164756007741	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
164756007742	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
164756007743	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
164756007744	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
164756007745	active site
164756007746	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
164756007747	Domain of unknown function DUF21; Region: DUF21; pfam01595
164756007748	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
164756007749	Transporter associated domain; Region: CorC_HlyC; smart01091
164756007750	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
164756007751	Domain of unknown function DUF21; Region: DUF21; pfam01595
164756007752	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
164756007753	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
164756007754	active site
164756007755	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
164756007756	metal ion-dependent adhesion site (MIDAS); other site
164756007757	classical (c) SDRs; Region: SDR_c; cd05233
164756007758	NAD(P) binding site [chemical binding]; other site
164756007759	active site
164756007760	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
164756007761	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
164756007762	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
164756007763	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756007764	hydrophobic ligand binding site; other site
164756007765	DoxX-like family; Region: DoxX_2; pfam13564
164756007766	PE-PPE domain; Region: PE-PPE; pfam08237
164756007767	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756007768	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756007769	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756007770	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
164756007771	acyltransferase PapA5; Provisional; Region: PRK09294
164756007772	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
164756007773	ABC-2 type transporter; Region: ABC2_membrane; cl17235
164756007774	ABC-2 type transporter; Region: ABC2_membrane; cl17235
164756007775	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
164756007776	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007777	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
164756007778	Walker A/P-loop; other site
164756007779	ATP binding site [chemical binding]; other site
164756007780	Q-loop/lid; other site
164756007781	ABC transporter signature motif; other site
164756007782	Walker B; other site
164756007783	D-loop; other site
164756007784	H-loop/switch region; other site
164756007785	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
164756007786	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756007787	active site
164756007788	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
164756007789	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756007790	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
164756007791	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
164756007792	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
164756007793	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756007794	active site
164756007795	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756007796	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
164756007797	KR domain; Region: KR; pfam08659
164756007798	NADP binding site [chemical binding]; other site
164756007799	active site
164756007800	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756007801	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756007802	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
164756007803	active site
164756007804	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
164756007805	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756007806	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756007807	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756007808	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756007809	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
164756007810	active site
164756007811	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
164756007812	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756007813	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
164756007814	KR domain; Region: KR; pfam08659
164756007815	NADP binding site [chemical binding]; other site
164756007816	active site
164756007817	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756007818	acyl-CoA synthetase; Validated; Region: PRK05850
164756007819	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
164756007820	acyl-activating enzyme (AAE) consensus motif; other site
164756007821	active site
164756007822	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
164756007823	glycine dehydrogenase; Provisional; Region: PRK05367
164756007824	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
164756007825	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756007826	catalytic residue [active]
164756007827	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
164756007828	tetramer interface [polypeptide binding]; other site
164756007829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756007830	catalytic residue [active]
164756007831	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
164756007832	DNA binding residues [nucleotide binding]
164756007833	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756007834	putative dimer interface [polypeptide binding]; other site
164756007835	Bifunctional nuclease; Region: DNase-RNase; pfam02577
164756007836	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
164756007837	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756007838	DNA binding residues [nucleotide binding]
164756007839	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
164756007840	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
164756007841	phosphopeptide binding site; other site
164756007842	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
164756007843	lipoyl attachment site [posttranslational modification]; other site
164756007844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
164756007845	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
164756007846	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
164756007847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
164756007848	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
164756007849	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
164756007850	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
164756007851	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
164756007852	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756007853	nucleotide binding region [chemical binding]; other site
164756007854	ATP-binding site [chemical binding]; other site
164756007855	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
164756007856	hypothetical protein; Provisional; Region: PRK06184
164756007857	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756007858	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
164756007859	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
164756007860	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007861	Walker A/P-loop; other site
164756007862	ATP binding site [chemical binding]; other site
164756007863	Q-loop/lid; other site
164756007864	ABC transporter signature motif; other site
164756007865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756007866	ABC transporter signature motif; other site
164756007867	Walker B; other site
164756007868	D-loop; other site
164756007869	H-loop/switch region; other site
164756007870	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
164756007871	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
164756007872	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
164756007873	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756007874	hypothetical protein; Validated; Region: PRK07121
164756007875	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756007876	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
164756007877	metal binding site [ion binding]; metal-binding site
164756007878	substrate binding site [chemical binding]; other site
164756007879	dimer interface [polypeptide binding]; other site
164756007880	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756007881	Domain of unknown function (DUF385); Region: DUF385; cl04387
164756007882	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
164756007883	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
164756007884	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
164756007885	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
164756007886	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
164756007887	TrkA-C domain; Region: TrkA_C; pfam02080
164756007888	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
164756007889	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
164756007890	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
164756007891	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756007892	substrate binding pocket [chemical binding]; other site
164756007893	catalytic triad [active]
164756007894	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
164756007895	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
164756007896	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
164756007897	classical (c) SDRs; Region: SDR_c; cd05233
164756007898	NAD(P) binding site [chemical binding]; other site
164756007899	active site
164756007900	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756007901	hydrophobic ligand binding site; other site
164756007902	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756007903	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
164756007904	putative acyl-acceptor binding pocket; other site
164756007905	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
164756007906	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
164756007907	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
164756007908	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
164756007909	FMN-binding pocket [chemical binding]; other site
164756007910	flavin binding motif; other site
164756007911	phosphate binding motif [ion binding]; other site
164756007912	beta-alpha-beta structure motif; other site
164756007913	NAD binding pocket [chemical binding]; other site
164756007914	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756007915	catalytic loop [active]
164756007916	iron binding site [ion binding]; other site
164756007917	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756007918	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756007919	SnoaL-like domain; Region: SnoaL_4; pfam13577
164756007920	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
164756007921	nudix motif; other site
164756007922	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
164756007923	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
164756007924	intracellular protease, PfpI family; Region: PfpI; TIGR01382
164756007925	proposed catalytic triad [active]
164756007926	conserved cys residue [active]
164756007927	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756007928	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756007929	substrate binding pocket [chemical binding]; other site
164756007930	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
164756007931	active site
164756007932	catalytic triad [active]
164756007933	oxyanion hole [active]
164756007934	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
164756007935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756007936	S-adenosylmethionine binding site [chemical binding]; other site
164756007937	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
164756007938	acyl-CoA synthetase; Validated; Region: PRK07798
164756007939	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756007940	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
164756007941	acyl-activating enzyme (AAE) consensus motif; other site
164756007942	acyl-activating enzyme (AAE) consensus motif; other site
164756007943	putative AMP binding site [chemical binding]; other site
164756007944	putative active site [active]
164756007945	putative CoA binding site [chemical binding]; other site
164756007946	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756007947	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
164756007948	PAS domain; Region: PAS_9; pfam13426
164756007949	putative active site [active]
164756007950	heme pocket [chemical binding]; other site
164756007951	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
164756007952	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
164756007953	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756007954	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756007955	acyl-activating enzyme (AAE) consensus motif; other site
164756007956	acyl-activating enzyme (AAE) consensus motif; other site
164756007957	putative AMP binding site [chemical binding]; other site
164756007958	putative active site [active]
164756007959	putative CoA binding site [chemical binding]; other site
164756007960	SOUL heme-binding protein; Region: SOUL; pfam04832
164756007961	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
164756007962	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756007963	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
164756007964	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756007965	DNA binding residues [nucleotide binding]
164756007966	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756007967	anti sigma factor interaction site; other site
164756007968	regulatory phosphorylation site [posttranslational modification]; other site
164756007969	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
164756007970	Methyltransferase domain; Region: Methyltransf_23; pfam13489
164756007971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
164756007972	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756007973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756007974	active site
164756007975	phosphorylation site [posttranslational modification]
164756007976	intermolecular recognition site; other site
164756007977	dimerization interface [polypeptide binding]; other site
164756007978	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756007979	DNA binding site [nucleotide binding]
164756007980	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756007981	dimerization interface [polypeptide binding]; other site
164756007982	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756007983	dimer interface [polypeptide binding]; other site
164756007984	phosphorylation site [posttranslational modification]
164756007985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756007986	ATP binding site [chemical binding]; other site
164756007987	Mg2+ binding site [ion binding]; other site
164756007988	G-X-G motif; other site
164756007989	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756007990	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756007991	active site
164756007992	ATP binding site [chemical binding]; other site
164756007993	substrate binding site [chemical binding]; other site
164756007994	activation loop (A-loop); other site
164756007995	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
164756007996	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
164756007997	N-acetyl-D-glucosamine binding site [chemical binding]; other site
164756007998	catalytic residue [active]
164756007999	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
164756008000	Phage capsid family; Region: Phage_capsid; pfam05065
164756008001	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
164756008002	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
164756008003	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
164756008004	HNH endonuclease; Region: HNH_3; pfam13392
164756008005	AAA domain; Region: AAA_25; pfam13481
164756008006	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
164756008007	Walker A motif; other site
164756008008	ATP binding site [chemical binding]; other site
164756008009	Walker B motif; other site
164756008010	Helix-turn-helix domain; Region: HTH_17; pfam12728
164756008011	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
164756008012	Int/Topo IB signature motif; other site
164756008013	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
164756008014	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
164756008015	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
164756008016	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
164756008017	GTP-binding protein Der; Reviewed; Region: PRK03003
164756008018	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
164756008019	G1 box; other site
164756008020	GTP/Mg2+ binding site [chemical binding]; other site
164756008021	Switch I region; other site
164756008022	G2 box; other site
164756008023	Switch II region; other site
164756008024	G3 box; other site
164756008025	G4 box; other site
164756008026	G5 box; other site
164756008027	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
164756008028	G1 box; other site
164756008029	GTP/Mg2+ binding site [chemical binding]; other site
164756008030	Switch I region; other site
164756008031	G2 box; other site
164756008032	G3 box; other site
164756008033	Switch II region; other site
164756008034	G4 box; other site
164756008035	G5 box; other site
164756008036	cytidylate kinase; Provisional; Region: cmk; PRK00023
164756008037	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
164756008038	active site
164756008039	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
164756008040	CMP-binding site; other site
164756008041	The sites determining sugar specificity; other site
164756008042	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
164756008043	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
164756008044	RNA binding surface [nucleotide binding]; other site
164756008045	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
164756008046	active site
164756008047	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
164756008048	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
164756008049	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
164756008050	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756008051	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
164756008052	Magnesium ion binding site [ion binding]; other site
164756008053	MMPL family; Region: MMPL; pfam03176
164756008054	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756008055	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756008056	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
164756008057	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756008058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756008059	homodimer interface [polypeptide binding]; other site
164756008060	catalytic residue [active]
164756008061	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
164756008062	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
164756008063	active site
164756008064	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
164756008065	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
164756008066	PYR/PP interface [polypeptide binding]; other site
164756008067	dimer interface [polypeptide binding]; other site
164756008068	TPP binding site [chemical binding]; other site
164756008069	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
164756008070	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
164756008071	TPP-binding site [chemical binding]; other site
164756008072	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756008073	Cytochrome P450; Region: p450; cl12078
164756008074	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
164756008075	putative DNA binding site [nucleotide binding]; other site
164756008076	putative Zn2+ binding site [ion binding]; other site
164756008077	O-methyltransferase; Region: Methyltransf_2; pfam00891
164756008078	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
164756008079	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
164756008080	active site
164756008081	DNA binding site [nucleotide binding]
164756008082	Int/Topo IB signature motif; other site
164756008083	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
164756008084	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
164756008085	dimer interface [polypeptide binding]; other site
164756008086	ADP-ribose binding site [chemical binding]; other site
164756008087	active site
164756008088	nudix motif; other site
164756008089	metal binding site [ion binding]; metal-binding site
164756008090	CTP synthetase; Validated; Region: pyrG; PRK05380
164756008091	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
164756008092	active site
164756008093	UTP binding site [chemical binding]; other site
164756008094	Catalytic site [active]
164756008095	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
164756008096	active site
164756008097	putative oxyanion hole; other site
164756008098	catalytic triad [active]
164756008099	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
164756008100	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
164756008101	Thiamine pyrophosphokinase; Region: TPK; cl08415
164756008102	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
164756008103	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
164756008104	active site
164756008105	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008106	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008107	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
164756008108	DNA repair protein RecN; Region: recN; TIGR00634
164756008109	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
164756008110	Walker A/P-loop; other site
164756008111	ATP binding site [chemical binding]; other site
164756008112	Q-loop/lid; other site
164756008113	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
164756008114	ABC transporter signature motif; other site
164756008115	Walker B; other site
164756008116	D-loop; other site
164756008117	H-loop/switch region; other site
164756008118	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
164756008119	ATP-NAD kinase; Region: NAD_kinase; pfam01513
164756008120	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
164756008121	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
164756008122	RNA binding surface [nucleotide binding]; other site
164756008123	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
164756008124	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
164756008125	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
164756008126	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
164756008127	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
164756008128	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
164756008129	active site
164756008130	HIGH motif; other site
164756008131	dimer interface [polypeptide binding]; other site
164756008132	KMSKS motif; other site
164756008133	S4 RNA-binding domain; Region: S4; smart00363
164756008134	RNA binding surface [nucleotide binding]; other site
164756008135	3-methyladenine DNA glycosylase; Reviewed; Region: PRK00802
164756008136	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
164756008137	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
164756008138	Walker A/P-loop; other site
164756008139	ATP binding site [chemical binding]; other site
164756008140	Q-loop/lid; other site
164756008141	ABC transporter signature motif; other site
164756008142	Walker B; other site
164756008143	D-loop; other site
164756008144	H-loop/switch region; other site
164756008145	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
164756008146	ABC-2 type transporter; Region: ABC2_membrane; cl17235
164756008147	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008148	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008149	Uncharacterized conserved protein [Function unknown]; Region: COG2835
164756008150	acyl-CoA synthetase; Validated; Region: PRK07868
164756008151	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
164756008152	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756008153	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756008154	active site
164756008155	CoA binding site [chemical binding]; other site
164756008156	AMP binding site [chemical binding]; other site
164756008157	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
164756008158	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756008159	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756008160	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756008161	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756008162	argininosuccinate lyase; Provisional; Region: PRK00855
164756008163	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
164756008164	active sites [active]
164756008165	tetramer interface [polypeptide binding]; other site
164756008166	argininosuccinate synthase; Provisional; Region: PRK13820
164756008167	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
164756008168	ANP binding site [chemical binding]; other site
164756008169	Substrate Binding Site II [chemical binding]; other site
164756008170	Substrate Binding Site I [chemical binding]; other site
164756008171	arginine repressor; Provisional; Region: PRK03341
164756008172	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
164756008173	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
164756008174	ornithine carbamoyltransferase; Provisional; Region: PRK00779
164756008175	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
164756008176	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
164756008177	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
164756008178	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756008179	inhibitor-cofactor binding pocket; inhibition site
164756008180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756008181	catalytic residue [active]
164756008182	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
164756008183	feedback inhibition sensing region; other site
164756008184	homohexameric interface [polypeptide binding]; other site
164756008185	nucleotide binding site [chemical binding]; other site
164756008186	N-acetyl-L-glutamate binding site [chemical binding]; other site
164756008187	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
164756008188	heterotetramer interface [polypeptide binding]; other site
164756008189	active site pocket [active]
164756008190	cleavage site
164756008191	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
164756008192	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
164756008193	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
164756008194	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
164756008195	putative tRNA-binding site [nucleotide binding]; other site
164756008196	B3/4 domain; Region: B3_4; pfam03483
164756008197	tRNA synthetase B5 domain; Region: B5; smart00874
164756008198	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
164756008199	dimer interface [polypeptide binding]; other site
164756008200	motif 1; other site
164756008201	motif 3; other site
164756008202	motif 2; other site
164756008203	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
164756008204	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
164756008205	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
164756008206	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
164756008207	dimer interface [polypeptide binding]; other site
164756008208	motif 1; other site
164756008209	active site
164756008210	motif 2; other site
164756008211	motif 3; other site
164756008212	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756008213	cyclase homology domain; Region: CHD; cd07302
164756008214	nucleotidyl binding site; other site
164756008215	metal binding site [ion binding]; metal-binding site
164756008216	dimer interface [polypeptide binding]; other site
164756008217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
164756008218	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756008219	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756008220	active site
164756008221	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
164756008222	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
164756008223	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
164756008224	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
164756008225	23S rRNA binding site [nucleotide binding]; other site
164756008226	L21 binding site [polypeptide binding]; other site
164756008227	L13 binding site [polypeptide binding]; other site
164756008228	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
164756008229	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
164756008230	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
164756008231	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
164756008232	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
164756008233	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
164756008234	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
164756008235	dimer interface [polypeptide binding]; other site
164756008236	putative anticodon binding site; other site
164756008237	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
164756008238	motif 1; other site
164756008239	dimer interface [polypeptide binding]; other site
164756008240	active site
164756008241	motif 2; other site
164756008242	motif 3; other site
164756008243	Predicted esterase [General function prediction only]; Region: COG0627
164756008244	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
164756008245	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
164756008246	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756008247	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756008248	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
164756008249	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
164756008250	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
164756008251	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
164756008252	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756008253	Domain of unknown function (DUF427); Region: DUF427; pfam04248
164756008254	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756008255	Cytochrome P450; Region: p450; cl12078
164756008256	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756008257	Ligand Binding Site [chemical binding]; other site
164756008258	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
164756008259	Fe-S cluster binding site [ion binding]; other site
164756008260	active site
164756008261	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
164756008262	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
164756008263	active site
164756008264	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
164756008265	catalytic triad [active]
164756008266	dimer interface [polypeptide binding]; other site
164756008267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756008268	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756008269	dimer interface [polypeptide binding]; other site
164756008270	phosphorylation site [posttranslational modification]
164756008271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756008272	ATP binding site [chemical binding]; other site
164756008273	Mg2+ binding site [ion binding]; other site
164756008274	G-X-G motif; other site
164756008275	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
164756008276	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
164756008277	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756008278	putative metal binding site [ion binding]; other site
164756008279	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756008280	dimerization interface [polypeptide binding]; other site
164756008281	putative DNA binding site [nucleotide binding]; other site
164756008282	putative Zn2+ binding site [ion binding]; other site
164756008283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756008284	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756008285	putative substrate translocation pore; other site
164756008286	excinuclease ABC subunit B; Provisional; Region: PRK05298
164756008287	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756008288	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756008289	nucleotide binding region [chemical binding]; other site
164756008290	ATP-binding site [chemical binding]; other site
164756008291	Ultra-violet resistance protein B; Region: UvrB; pfam12344
164756008292	UvrB/uvrC motif; Region: UVR; pfam02151
164756008293	Protein of unknown function (DUF402); Region: DUF402; cl00979
164756008294	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
164756008295	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
164756008296	CoA-binding site [chemical binding]; other site
164756008297	ATP-binding [chemical binding]; other site
164756008298	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
164756008299	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
164756008300	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
164756008301	RNA binding site [nucleotide binding]; other site
164756008302	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
164756008303	RNA binding site [nucleotide binding]; other site
164756008304	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
164756008305	RNA binding site [nucleotide binding]; other site
164756008306	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
164756008307	RNA binding site [nucleotide binding]; other site
164756008308	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008309	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756008311	NADH(P)-binding; Region: NAD_binding_10; pfam13460
164756008312	NAD(P) binding site [chemical binding]; other site
164756008313	active site
164756008314	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
164756008315	Protease prsW family; Region: PrsW-protease; pfam13367
164756008316	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
164756008317	5'-3' exonuclease; Region: 53EXOc; smart00475
164756008318	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
164756008319	active site
164756008320	metal binding site 1 [ion binding]; metal-binding site
164756008321	putative 5' ssDNA interaction site; other site
164756008322	metal binding site 3; metal-binding site
164756008323	metal binding site 2 [ion binding]; metal-binding site
164756008324	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
164756008325	putative DNA binding site [nucleotide binding]; other site
164756008326	putative metal binding site [ion binding]; other site
164756008327	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
164756008328	active site
164756008329	substrate binding site [chemical binding]; other site
164756008330	DNA polymerase I; Provisional; Region: PRK05755
164756008331	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
164756008332	active site
164756008333	DNA binding site [nucleotide binding]
164756008334	catalytic site [active]
164756008335	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
164756008336	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756008337	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
164756008338	putative dimerization interface [polypeptide binding]; other site
164756008339	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
164756008340	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756008341	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
164756008342	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756008343	lipid-transfer protein; Provisional; Region: PRK06059
164756008344	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756008345	active site
164756008346	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
164756008347	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
164756008348	Walker A/P-loop; other site
164756008349	ATP binding site [chemical binding]; other site
164756008350	Q-loop/lid; other site
164756008351	ABC transporter signature motif; other site
164756008352	Walker B; other site
164756008353	D-loop; other site
164756008354	H-loop/switch region; other site
164756008355	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
164756008356	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
164756008357	Walker A/P-loop; other site
164756008358	ATP binding site [chemical binding]; other site
164756008359	Q-loop/lid; other site
164756008360	ABC transporter signature motif; other site
164756008361	Walker B; other site
164756008362	D-loop; other site
164756008363	H-loop/switch region; other site
164756008364	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
164756008365	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
164756008366	TM-ABC transporter signature motif; other site
164756008367	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
164756008368	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
164756008369	TM-ABC transporter signature motif; other site
164756008370	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
164756008371	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
164756008372	dimerization interface [polypeptide binding]; other site
164756008373	ligand binding site [chemical binding]; other site
164756008374	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
164756008375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756008376	active site
164756008377	phosphorylation site [posttranslational modification]
164756008378	intermolecular recognition site; other site
164756008379	dimerization interface [polypeptide binding]; other site
164756008380	ANTAR domain; Region: ANTAR; pfam03861
164756008381	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
164756008382	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
164756008383	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
164756008384	agmatinase; Region: agmatinase; TIGR01230
164756008385	oligomer interface [polypeptide binding]; other site
164756008386	putative active site [active]
164756008387	Mn binding site [ion binding]; other site
164756008388	Heme NO binding associated; Region: HNOBA; pfam07701
164756008389	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
164756008390	cyclase homology domain; Region: CHD; cd07302
164756008391	nucleotidyl binding site; other site
164756008392	metal binding site [ion binding]; metal-binding site
164756008393	dimer interface [polypeptide binding]; other site
164756008394	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
164756008395	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756008396	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756008397	hydrophobic ligand binding site; other site
164756008398	Ferritin-like domain; Region: Ferritin; pfam00210
164756008399	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
164756008400	dimerization interface [polypeptide binding]; other site
164756008401	DPS ferroxidase diiron center [ion binding]; other site
164756008402	ion pore; other site
164756008403	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756008404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756008405	active site
164756008406	phosphorylation site [posttranslational modification]
164756008407	intermolecular recognition site; other site
164756008408	dimerization interface [polypeptide binding]; other site
164756008409	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756008410	DNA binding residues [nucleotide binding]
164756008411	dimerization interface [polypeptide binding]; other site
164756008412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756008413	ATP binding site [chemical binding]; other site
164756008414	G-X-G motif; other site
164756008415	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
164756008416	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
164756008417	Walker A/P-loop; other site
164756008418	ATP binding site [chemical binding]; other site
164756008419	Q-loop/lid; other site
164756008420	ABC transporter signature motif; other site
164756008421	Walker B; other site
164756008422	D-loop; other site
164756008423	H-loop/switch region; other site
164756008424	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
164756008425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756008426	dimer interface [polypeptide binding]; other site
164756008427	conserved gate region; other site
164756008428	putative PBP binding loops; other site
164756008429	ABC-ATPase subunit interface; other site
164756008430	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756008431	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
164756008432	substrate binding pocket [chemical binding]; other site
164756008433	membrane-bound complex binding site; other site
164756008434	hinge residues; other site
164756008435	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
164756008436	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
164756008437	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
164756008438	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
164756008439	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
164756008440	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
164756008441	Walker A/P-loop; other site
164756008442	ATP binding site [chemical binding]; other site
164756008443	Q-loop/lid; other site
164756008444	ABC transporter signature motif; other site
164756008445	Walker B; other site
164756008446	D-loop; other site
164756008447	H-loop/switch region; other site
164756008448	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
164756008449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756008450	Walker A/P-loop; other site
164756008451	ATP binding site [chemical binding]; other site
164756008452	Q-loop/lid; other site
164756008453	ABC transporter signature motif; other site
164756008454	Walker B; other site
164756008455	D-loop; other site
164756008456	H-loop/switch region; other site
164756008457	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
164756008458	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
164756008459	active site
164756008460	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
164756008461	catalytic triad [active]
164756008462	dimer interface [polypeptide binding]; other site
164756008463	pyruvate kinase; Provisional; Region: PRK06247
164756008464	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
164756008465	domain interfaces; other site
164756008466	active site
164756008467	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
164756008468	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756008469	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
164756008470	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
164756008471	active site
164756008472	dimer interface [polypeptide binding]; other site
164756008473	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
164756008474	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
164756008475	active site
164756008476	FMN binding site [chemical binding]; other site
164756008477	substrate binding site [chemical binding]; other site
164756008478	3Fe-4S cluster binding site [ion binding]; other site
164756008479	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
164756008480	domain interface; other site
164756008481	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
164756008482	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756008483	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756008484	active site
164756008485	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
164756008486	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
164756008487	substrate binding site [chemical binding]; other site
164756008488	active site
164756008489	catalytic residues [active]
164756008490	heterodimer interface [polypeptide binding]; other site
164756008491	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
164756008492	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
164756008493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756008494	catalytic residue [active]
164756008495	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
164756008496	active site
164756008497	ribulose/triose binding site [chemical binding]; other site
164756008498	phosphate binding site [ion binding]; other site
164756008499	substrate (anthranilate) binding pocket [chemical binding]; other site
164756008500	product (indole) binding pocket [chemical binding]; other site
164756008501	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
164756008502	anthranilate synthase component I; Provisional; Region: PRK13571
164756008503	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
164756008504	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
164756008505	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
164756008506	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
164756008507	catalytic triad [active]
164756008508	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756008509	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756008510	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
164756008511	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
164756008512	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
164756008513	substrate binding site [chemical binding]; other site
164756008514	glutamase interaction surface [polypeptide binding]; other site
164756008515	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
164756008516	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
164756008517	active site
164756008518	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
164756008519	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
164756008520	catalytic residues [active]
164756008521	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
164756008522	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
164756008523	putative active site [active]
164756008524	oxyanion strand; other site
164756008525	catalytic triad [active]
164756008526	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
164756008527	putative active site pocket [active]
164756008528	4-fold oligomerization interface [polypeptide binding]; other site
164756008529	metal binding residues [ion binding]; metal-binding site
164756008530	3-fold/trimer interface [polypeptide binding]; other site
164756008531	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
164756008532	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756008533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756008534	homodimer interface [polypeptide binding]; other site
164756008535	catalytic residue [active]
164756008536	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
164756008537	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
164756008538	NAD binding site [chemical binding]; other site
164756008539	dimerization interface [polypeptide binding]; other site
164756008540	product binding site; other site
164756008541	substrate binding site [chemical binding]; other site
164756008542	zinc binding site [ion binding]; other site
164756008543	catalytic residues [active]
164756008544	Domain of unknown function (DUF385); Region: DUF385; cl04387
164756008545	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
164756008546	active site
164756008547	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
164756008548	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
164756008549	dimerization interface [polypeptide binding]; other site
164756008550	active site
164756008551	L-aspartate oxidase; Provisional; Region: PRK07804
164756008552	L-aspartate oxidase; Provisional; Region: PRK06175
164756008553	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
164756008554	quinolinate synthetase; Provisional; Region: PRK09375
164756008555	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
164756008556	nudix motif; other site
164756008557	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
164756008558	Secretory lipase; Region: LIP; pfam03583
164756008559	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
164756008560	biotin synthase; Validated; Region: PRK06256
164756008561	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756008562	FeS/SAM binding site; other site
164756008563	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
164756008564	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008565	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
164756008566	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
164756008567	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
164756008568	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
164756008569	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
164756008570	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756008571	catalytic residue [active]
164756008572	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
164756008573	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756008574	inhibitor-cofactor binding pocket; inhibition site
164756008575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756008576	catalytic residue [active]
164756008577	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756008578	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
164756008579	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
164756008580	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
164756008581	active site
164756008582	catalytic site [active]
164756008583	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
164756008584	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
164756008585	active site
164756008586	catalytic site [active]
164756008587	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
164756008588	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
164756008589	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
164756008590	catalytic site [active]
164756008591	active site
164756008592	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
164756008593	threonine dehydratase; Validated; Region: PRK08639
164756008594	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
164756008595	tetramer interface [polypeptide binding]; other site
164756008596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756008597	catalytic residue [active]
164756008598	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
164756008599	putative Ile/Val binding site [chemical binding]; other site
164756008600	Domain of unknown function (DUF385); Region: DUF385; pfam04075
164756008601	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
164756008602	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
164756008603	active site
164756008604	PHP Thumb interface [polypeptide binding]; other site
164756008605	metal binding site [ion binding]; metal-binding site
164756008606	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
164756008607	generic binding surface II; other site
164756008608	generic binding surface I; other site
164756008609	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008610	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008611	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
164756008612	YCII-related domain; Region: YCII; cl00999
164756008613	Predicted permeases [General function prediction only]; Region: RarD; COG2962
164756008614	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
164756008615	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
164756008616	RNA binding surface [nucleotide binding]; other site
164756008617	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
164756008618	active site
164756008619	lipoprotein signal peptidase; Provisional; Region: PRK14764
164756008620	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
164756008621	active site
164756008622	homotetramer interface [polypeptide binding]; other site
164756008623	homodimer interface [polypeptide binding]; other site
164756008624	DNA polymerase IV; Provisional; Region: PRK03348
164756008625	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
164756008626	active site
164756008627	DNA binding site [nucleotide binding]
164756008628	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
164756008629	RNA binding surface [nucleotide binding]; other site
164756008630	Predicted transcriptional regulators [Transcription]; Region: COG1733
164756008631	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
164756008632	Predicted transcriptional regulators [Transcription]; Region: COG1733
164756008633	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
164756008634	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
164756008635	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
164756008636	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
164756008637	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756008638	active site
164756008639	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
164756008640	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
164756008641	HIGH motif; other site
164756008642	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
164756008643	active site
164756008644	KMSKS motif; other site
164756008645	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
164756008646	tRNA binding surface [nucleotide binding]; other site
164756008647	anticodon binding site; other site
164756008648	peptide synthase; Provisional; Region: PRK12467
164756008649	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
164756008650	acyl-CoA synthetase; Validated; Region: PRK05850
164756008651	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
164756008652	acyl-activating enzyme (AAE) consensus motif; other site
164756008653	active site
164756008654	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756008655	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
164756008656	Walker A/P-loop; other site
164756008657	ATP binding site [chemical binding]; other site
164756008658	Q-loop/lid; other site
164756008659	ABC transporter signature motif; other site
164756008660	Walker B; other site
164756008661	D-loop; other site
164756008662	H-loop/switch region; other site
164756008663	ABC-2 type transporter; Region: ABC2_membrane; cl17235
164756008664	ABC-2 type transporter; Region: ABC2_membrane; cl17235
164756008665	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
164756008666	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
164756008667	active site
164756008668	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756008669	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
164756008670	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756008671	active site
164756008672	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
164756008673	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
164756008674	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
164756008675	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
164756008676	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
164756008677	Transport protein; Region: actII; TIGR00833
164756008678	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
164756008679	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
164756008680	homodimer interface [polypeptide binding]; other site
164756008681	active site
164756008682	TDP-binding site; other site
164756008683	acceptor substrate-binding pocket; other site
164756008684	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756008685	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756008686	Condensation domain; Region: Condensation; pfam00668
164756008687	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
164756008688	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756008689	active site
164756008690	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756008691	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
164756008692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756008693	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
164756008694	Enoylreductase; Region: PKS_ER; smart00829
164756008695	NAD(P) binding site [chemical binding]; other site
164756008696	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
164756008697	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
164756008698	putative NADP binding site [chemical binding]; other site
164756008699	active site
164756008700	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756008701	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756008702	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756008703	membrane ATPase/protein kinase; Provisional; Region: PRK09435
164756008704	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
164756008705	Walker A; other site
164756008706	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
164756008707	G4 box; other site
164756008708	G5 box; other site
164756008709	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
164756008710	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
164756008711	active site
164756008712	substrate binding site [chemical binding]; other site
164756008713	coenzyme B12 binding site [chemical binding]; other site
164756008714	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
164756008715	B12 binding site [chemical binding]; other site
164756008716	cobalt ligand [ion binding]; other site
164756008717	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
164756008718	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
164756008719	heterodimer interface [polypeptide binding]; other site
164756008720	substrate interaction site [chemical binding]; other site
164756008721	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
164756008722	Uncharacterized conserved protein [Function unknown]; Region: COG0398
164756008723	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
164756008724	DoxX-like family; Region: DoxX_2; pfam13564
164756008725	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
164756008726	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
164756008727	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
164756008728	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
164756008729	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
164756008730	active site
164756008731	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
164756008732	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
164756008733	active site
164756008734	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
164756008735	proteasome ATPase; Region: pup_AAA; TIGR03689
164756008736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756008737	Walker A motif; other site
164756008738	ATP binding site [chemical binding]; other site
164756008739	Walker B motif; other site
164756008740	arginine finger; other site
164756008741	Protein of unknown function (DUF503); Region: DUF503; pfam04456
164756008742	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
164756008743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756008744	S-adenosylmethionine binding site [chemical binding]; other site
164756008745	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
164756008746	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
164756008747	DinB superfamily; Region: DinB_2; pfam12867
164756008748	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008749	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
164756008750	putative dimer interface [polypeptide binding]; other site
164756008751	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756008752	mercuric reductase; Validated; Region: PRK06370
164756008753	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756008754	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756008755	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
164756008756	Predicted membrane protein [Function unknown]; Region: COG3918
164756008757	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
164756008758	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
164756008759	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
164756008760	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
164756008761	homodimer interface [polypeptide binding]; other site
164756008762	putative metal binding site [ion binding]; other site
164756008763	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
164756008764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756008765	putative substrate translocation pore; other site
164756008766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756008767	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
164756008768	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756008769	motif II; other site
164756008770	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
164756008771	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
164756008772	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
164756008773	substrate binding pocket [chemical binding]; other site
164756008774	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
164756008775	B12 binding site [chemical binding]; other site
164756008776	cobalt ligand [ion binding]; other site
164756008777	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
164756008778	PAC2 family; Region: PAC2; pfam09754
164756008779	Uncharacterized conserved protein [Function unknown]; Region: COG5361
164756008780	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
164756008781	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
164756008782	short chain dehydrogenase; Provisional; Region: PRK05872
164756008783	classical (c) SDRs; Region: SDR_c; cd05233
164756008784	NAD(P) binding site [chemical binding]; other site
164756008785	active site
164756008786	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
164756008787	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
164756008788	active site
164756008789	HIGH motif; other site
164756008790	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
164756008791	active site
164756008792	KMSKS motif; other site
164756008793	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
164756008794	putative tRNA binding surface [nucleotide binding]; other site
164756008795	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
164756008796	active site
164756008797	conserved hypothetical protein; Region: TIGR03843
164756008798	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
164756008799	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756008800	catalytic core [active]
164756008801	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
164756008802	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
164756008803	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
164756008804	quinone interaction residues [chemical binding]; other site
164756008805	active site
164756008806	catalytic residues [active]
164756008807	FMN binding site [chemical binding]; other site
164756008808	substrate binding site [chemical binding]; other site
164756008809	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
164756008810	substrate binding site [chemical binding]; other site
164756008811	hypothetical protein; Provisional; Region: PRK07906
164756008812	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
164756008813	putative metal binding site [ion binding]; other site
164756008814	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
164756008815	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
164756008816	catalytic residues [active]
164756008817	catalytic nucleophile [active]
164756008818	Recombinase; Region: Recombinase; pfam07508
164756008819	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
164756008820	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756008821	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
164756008822	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756008823	non-specific DNA binding site [nucleotide binding]; other site
164756008824	salt bridge; other site
164756008825	sequence-specific DNA binding site [nucleotide binding]; other site
164756008826	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
164756008827	nudix motif; other site
164756008828	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
164756008829	Zn2+ binding site [ion binding]; other site
164756008830	Mg2+ binding site [ion binding]; other site
164756008831	ThiF family; Region: ThiF; pfam00899
164756008832	ATP binding site [chemical binding]; other site
164756008833	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
164756008834	active site
164756008835	NTP binding site [chemical binding]; other site
164756008836	metal binding triad [ion binding]; metal-binding site
164756008837	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
164756008838	active site
164756008839	nucleophile elbow; other site
164756008840	putative transposase OrfB; Reviewed; Region: PHA02517
164756008841	Integrase core domain; Region: rve; pfam00665
164756008842	Integrase core domain; Region: rve_2; pfam13333
164756008843	Integrase core domain; Region: rve; pfam00665
164756008844	Integrase core domain; Region: rve_3; cl15866
164756008845	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756008846	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756008847	active site
164756008848	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
164756008849	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
164756008850	NAD binding site [chemical binding]; other site
164756008851	catalytic Zn binding site [ion binding]; other site
164756008852	substrate binding site [chemical binding]; other site
164756008853	structural Zn binding site [ion binding]; other site
164756008854	SCP-2 sterol transfer family; Region: SCP2; pfam02036
164756008855	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
164756008856	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
164756008857	putative active site [active]
164756008858	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756008859	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756008860	active site
164756008861	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
164756008862	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
164756008863	dimer interface [polypeptide binding]; other site
164756008864	acyl-activating enzyme (AAE) consensus motif; other site
164756008865	putative active site [active]
164756008866	AMP binding site [chemical binding]; other site
164756008867	putative CoA binding site [chemical binding]; other site
164756008868	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
164756008869	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
164756008870	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
164756008871	3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141
164756008872	Cytochrome P450; Region: p450; cl12078
164756008873	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756008874	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756008875	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
164756008876	Transposase; Region: HTH_Tnp_1; pfam01527
164756008877	HTH-like domain; Region: HTH_21; pfam13276
164756008878	Integrase core domain; Region: rve; pfam00665
164756008879	Integrase core domain; Region: rve_3; pfam13683
164756008880	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756008881	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756008882	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
164756008883	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756008884	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756008885	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756008886	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756008887	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
164756008888	classical (c) SDRs; Region: SDR_c; cd05233
164756008889	NAD(P) binding site [chemical binding]; other site
164756008890	active site
164756008891	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008892	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008893	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
164756008894	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
164756008895	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008896	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
164756008897	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
164756008898	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
164756008899	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
164756008900	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756008901	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
164756008902	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
164756008903	carboxyltransferase (CT) interaction site; other site
164756008904	biotinylation site [posttranslational modification]; other site
164756008905	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756008906	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756008907	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756008908	active site
164756008909	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
164756008910	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756008911	acyl-activating enzyme (AAE) consensus motif; other site
164756008912	AMP binding site [chemical binding]; other site
164756008913	active site
164756008914	CoA binding site [chemical binding]; other site
164756008915	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008916	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008917	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
164756008918	TIGR03084 family protein; Region: TIGR03084
164756008919	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
164756008920	Wyosine base formation; Region: Wyosine_form; pfam08608
164756008921	enoyl-CoA hydratase; Provisional; Region: PRK06494
164756008922	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756008923	substrate binding site [chemical binding]; other site
164756008924	oxyanion hole (OAH) forming residues; other site
164756008925	trimer interface [polypeptide binding]; other site
164756008926	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756008927	active site 2 [active]
164756008928	active site 1 [active]
164756008929	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
164756008930	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756008931	active site 2 [active]
164756008932	active site 1 [active]
164756008933	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
164756008934	active site
164756008935	catalytic site [active]
164756008936	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756008937	methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271
164756008938	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
164756008939	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
164756008940	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756008941	thiolase; Provisional; Region: PRK06158
164756008942	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756008943	active site
164756008944	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
164756008945	Helix-turn-helix domain; Region: HTH_18; pfam12833
164756008946	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756008947	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
164756008948	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756008949	catalytic loop [active]
164756008950	iron binding site [ion binding]; other site
164756008951	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756008952	Cytochrome P450; Region: p450; cl12078
164756008953	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
164756008954	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756008955	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756008956	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008957	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008958	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756008959	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756008960	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756008961	CoenzymeA binding site [chemical binding]; other site
164756008962	subunit interaction site [polypeptide binding]; other site
164756008963	PHB binding site; other site
164756008964	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756008965	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756008966	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
164756008967	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
164756008968	active site
164756008969	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756008970	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188
164756008971	NAD(P) binding site [chemical binding]; other site
164756008972	Uncharacterized conserved protein [Function unknown]; Region: COG2128
164756008973	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
164756008974	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
164756008975	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
164756008976	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
164756008977	[4Fe-4S] binding site [ion binding]; other site
164756008978	molybdopterin cofactor binding site; other site
164756008979	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
164756008980	molybdopterin cofactor binding site; other site
164756008981	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
164756008982	Flavodoxin; Region: Flavodoxin_1; pfam00258
164756008983	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
164756008984	FAD binding pocket [chemical binding]; other site
164756008985	FAD binding motif [chemical binding]; other site
164756008986	catalytic residues [active]
164756008987	NAD binding pocket [chemical binding]; other site
164756008988	phosphate binding motif [ion binding]; other site
164756008989	beta-alpha-beta structure motif; other site
164756008990	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
164756008991	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756008992	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
164756008993	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
164756008994	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756008995	iron-sulfur cluster [ion binding]; other site
164756008996	[2Fe-2S] cluster binding site [ion binding]; other site
164756008997	PknH-like extracellular domain; Region: PknH_C; pfam14032
164756008998	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756008999	Ligand Binding Site [chemical binding]; other site
164756009000	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
164756009001	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
164756009002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
164756009003	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
164756009004	PAS domain; Region: PAS; smart00091
164756009005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756009006	ATP binding site [chemical binding]; other site
164756009007	Mg2+ binding site [ion binding]; other site
164756009008	G-X-G motif; other site
164756009009	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
164756009010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756009011	active site
164756009012	phosphorylation site [posttranslational modification]
164756009013	intermolecular recognition site; other site
164756009014	dimerization interface [polypeptide binding]; other site
164756009015	Transcriptional regulator; Region: CitT; pfam12431
164756009016	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756009017	Cytochrome P450; Region: p450; cl12078
164756009018	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
164756009019	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
164756009020	putative active site [active]
164756009021	catalytic site [active]
164756009022	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
164756009023	putative active site [active]
164756009024	catalytic site [active]
164756009025	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756009026	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756009027	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
164756009028	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
164756009029	catalytic triad [active]
164756009030	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
164756009031	putative hydrophobic ligand binding site [chemical binding]; other site
164756009032	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756009033	TIGR01777 family protein; Region: yfcH
164756009034	NAD(P) binding site [chemical binding]; other site
164756009035	active site
164756009036	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756009037	active site
164756009038	DivIVA domain; Region: DivI1A_domain; TIGR03544
164756009039	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
164756009040	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
164756009041	Predicted integral membrane protein [Function unknown]; Region: COG0762
164756009042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
164756009043	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
164756009044	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
164756009045	catalytic residue [active]
164756009046	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
164756009047	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
164756009048	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
164756009049	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
164756009050	nucleotide binding site [chemical binding]; other site
164756009051	SulA interaction site; other site
164756009052	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
164756009053	Cell division protein FtsQ; Region: FtsQ; pfam03799
164756009054	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
164756009055	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
164756009056	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
164756009057	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
164756009058	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
164756009059	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
164756009060	active site
164756009061	homodimer interface [polypeptide binding]; other site
164756009062	cell division protein FtsW; Region: ftsW; TIGR02614
164756009063	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
164756009064	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
164756009065	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
164756009066	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
164756009067	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
164756009068	Mg++ binding site [ion binding]; other site
164756009069	putative catalytic motif [active]
164756009070	putative substrate binding site [chemical binding]; other site
164756009071	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
164756009072	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
164756009073	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
164756009074	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
164756009075	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
164756009076	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
164756009077	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
164756009078	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
164756009079	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
164756009080	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
164756009081	MraW methylase family; Region: Methyltransf_5; cl17771
164756009082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
164756009083	MraZ protein; Region: MraZ; pfam02381
164756009084	MraZ protein; Region: MraZ; pfam02381
164756009085	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
164756009086	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
164756009087	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
164756009088	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
164756009089	substrate binding pocket [chemical binding]; other site
164756009090	chain length determination region; other site
164756009091	substrate-Mg2+ binding site; other site
164756009092	catalytic residues [active]
164756009093	aspartate-rich region 1; other site
164756009094	active site lid residues [active]
164756009095	aspartate-rich region 2; other site
164756009096	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
164756009097	Helix-turn-helix domain; Region: HTH_17; cl17695
164756009098	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756009099	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756009100	active site
164756009101	ATP binding site [chemical binding]; other site
164756009102	substrate binding site [chemical binding]; other site
164756009103	activation loop (A-loop); other site
164756009104	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
164756009105	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
164756009106	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756009107	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
164756009108	putative acyl-acceptor binding pocket; other site
164756009109	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
164756009110	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
164756009111	P loop; other site
164756009112	Nucleotide binding site [chemical binding]; other site
164756009113	DTAP/Switch II; other site
164756009114	Switch I; other site
164756009115	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
164756009116	putative hydrophobic ligand binding site [chemical binding]; other site
164756009117	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
164756009118	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
164756009119	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
164756009120	acyl-activating enzyme (AAE) consensus motif; other site
164756009121	putative AMP binding site [chemical binding]; other site
164756009122	putative active site [active]
164756009123	putative CoA binding site [chemical binding]; other site
164756009124	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
164756009125	agmatinase; Region: agmatinase; TIGR01230
164756009126	oligomer interface [polypeptide binding]; other site
164756009127	putative active site [active]
164756009128	Mn binding site [ion binding]; other site
164756009129	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
164756009130	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
164756009131	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
164756009132	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756009133	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
164756009134	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
164756009135	NlpC/P60 family; Region: NLPC_P60; pfam00877
164756009136	hypothetical protein; Validated; Region: PRK07883
164756009137	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
164756009138	active site
164756009139	catalytic site [active]
164756009140	substrate binding site [chemical binding]; other site
164756009141	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
164756009142	GIY-YIG motif/motif A; other site
164756009143	active site
164756009144	catalytic site [active]
164756009145	putative DNA binding site [nucleotide binding]; other site
164756009146	metal binding site [ion binding]; metal-binding site
164756009147	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
164756009148	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
164756009149	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
164756009150	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
164756009151	Subunit I/III interface [polypeptide binding]; other site
164756009152	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
164756009153	Cytochrome c; Region: Cytochrom_C; pfam00034
164756009154	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
164756009155	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
164756009156	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
164756009157	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
164756009158	iron-sulfur cluster [ion binding]; other site
164756009159	[2Fe-2S] cluster binding site [ion binding]; other site
164756009160	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
164756009161	heme bH binding site [chemical binding]; other site
164756009162	intrachain domain interface; other site
164756009163	heme bL binding site [chemical binding]; other site
164756009164	interchain domain interface [polypeptide binding]; other site
164756009165	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
164756009166	Qo binding site; other site
164756009167	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
164756009168	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
164756009169	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
164756009170	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
164756009171	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
164756009172	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
164756009173	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
164756009174	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
164756009175	active site
164756009176	dimer interface [polypeptide binding]; other site
164756009177	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
164756009178	Ligand Binding Site [chemical binding]; other site
164756009179	Molecular Tunnel; other site
164756009180	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
164756009181	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
164756009182	substrate binding site [chemical binding]; other site
164756009183	ATP binding site [chemical binding]; other site
164756009184	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
164756009185	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
164756009186	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
164756009187	homotrimer interface [polypeptide binding]; other site
164756009188	Walker A motif; other site
164756009189	GTP binding site [chemical binding]; other site
164756009190	Walker B motif; other site
164756009191	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
164756009192	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
164756009193	putative dimer interface [polypeptide binding]; other site
164756009194	active site pocket [active]
164756009195	putative cataytic base [active]
164756009196	cobalamin synthase; Reviewed; Region: cobS; PRK00235
164756009197	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
164756009198	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
164756009199	homodimer interface [polypeptide binding]; other site
164756009200	substrate-cofactor binding pocket; other site
164756009201	catalytic residue [active]
164756009202	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
164756009203	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
164756009204	multifunctional aminopeptidase A; Provisional; Region: PRK00913
164756009205	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
164756009206	interface (dimer of trimers) [polypeptide binding]; other site
164756009207	Substrate-binding/catalytic site; other site
164756009208	Zn-binding sites [ion binding]; other site
164756009209	short chain dehydrogenase; Validated; Region: PRK05855
164756009210	classical (c) SDRs; Region: SDR_c; cd05233
164756009211	NAD(P) binding site [chemical binding]; other site
164756009212	active site
164756009213	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
164756009214	E3 interaction surface; other site
164756009215	lipoyl attachment site [posttranslational modification]; other site
164756009216	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
164756009217	E3 interaction surface; other site
164756009218	lipoyl attachment site [posttranslational modification]; other site
164756009219	e3 binding domain; Region: E3_binding; pfam02817
164756009220	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
164756009221	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
164756009222	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
164756009223	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756009224	NAD(P) binding site [chemical binding]; other site
164756009225	active site
164756009226	lipoate-protein ligase B; Provisional; Region: PRK14345
164756009227	lipoyl synthase; Provisional; Region: PRK05481
164756009228	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756009229	FeS/SAM binding site; other site
164756009230	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
164756009231	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
164756009232	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
164756009233	active site
164756009234	RDD family; Region: RDD; pfam06271
164756009235	glutamine synthetase, type I; Region: GlnA; TIGR00653
164756009236	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
164756009237	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756009238	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
164756009239	putative active site [active]
164756009240	dimerization interface [polypeptide binding]; other site
164756009241	putative tRNAtyr binding site [nucleotide binding]; other site
164756009242	DoxX; Region: DoxX; pfam07681
164756009243	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
164756009244	B12 binding domain; Region: B12-binding_2; pfam02607
164756009245	B12 binding domain; Region: B12-binding; pfam02310
164756009246	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756009247	anti sigma factor interaction site; other site
164756009248	regulatory phosphorylation site [posttranslational modification]; other site
164756009249	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756009250	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756009251	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
164756009252	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
164756009253	metal binding triad; other site
164756009254	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
164756009255	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
164756009256	metal binding triad; other site
164756009257	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
164756009258	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
164756009259	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
164756009260	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756009261	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
164756009262	TAP-like protein; Region: Abhydrolase_4; pfam08386
164756009263	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
164756009264	TAP-like protein; Region: Abhydrolase_4; pfam08386
164756009265	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756009266	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756009267	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
164756009268	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
164756009269	oligomerization interface [polypeptide binding]; other site
164756009270	active site
164756009271	metal binding site [ion binding]; metal-binding site
164756009272	enoyl-CoA hydratase; Provisional; Region: PRK06688
164756009273	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756009274	substrate binding site [chemical binding]; other site
164756009275	oxyanion hole (OAH) forming residues; other site
164756009276	trimer interface [polypeptide binding]; other site
164756009277	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
164756009278	putative active site; other site
164756009279	putative metal binding residues [ion binding]; other site
164756009280	signature motif; other site
164756009281	putative triphosphate binding site [ion binding]; other site
164756009282	CHAD domain; Region: CHAD; pfam05235
164756009283	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756009284	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756009285	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756009286	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
164756009287	RibD C-terminal domain; Region: RibD_C; cl17279
164756009288	CAAX protease self-immunity; Region: Abi; pfam02517
164756009289	Methyltransferase domain; Region: Methyltransf_31; pfam13847
164756009290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756009291	S-adenosylmethionine binding site [chemical binding]; other site
164756009292	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
164756009293	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756009294	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
164756009295	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756009296	sequence-specific DNA binding site [nucleotide binding]; other site
164756009297	salt bridge; other site
164756009298	Cupin domain; Region: Cupin_2; pfam07883
164756009299	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
164756009300	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
164756009301	RNA/DNA hybrid binding site [nucleotide binding]; other site
164756009302	active site
164756009303	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756009304	catalytic core [active]
164756009305	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
164756009306	Putative zinc ribbon domain; Region: DUF164; pfam02591
164756009307	Uncharacterized conserved protein [Function unknown]; Region: COG0327
164756009308	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
164756009309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
164756009310	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
164756009311	hypothetical protein; Provisional; Region: PRK07908
164756009312	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756009313	homodimer interface [polypeptide binding]; other site
164756009314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756009315	catalytic residue [active]
164756009316	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
164756009317	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756009318	motif II; other site
164756009319	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
164756009320	Low molecular weight phosphatase family; Region: LMWPc; cd00115
164756009321	active site
164756009322	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
164756009323	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
164756009324	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756009325	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756009326	DNA binding residues [nucleotide binding]
164756009327	dimerization interface [polypeptide binding]; other site
164756009328	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
164756009329	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
164756009330	glutaminase active site [active]
164756009331	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
164756009332	dimer interface [polypeptide binding]; other site
164756009333	active site
164756009334	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
164756009335	dimer interface [polypeptide binding]; other site
164756009336	active site
164756009337	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
164756009338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756009339	NAD(P) binding site [chemical binding]; other site
164756009340	active site
164756009341	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
164756009342	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
164756009343	NodB motif; other site
164756009344	putative active site [active]
164756009345	putative catalytic site [active]
164756009346	putative Zn binding site [ion binding]; other site
164756009347	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
164756009348	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
164756009349	DXD motif; other site
164756009350	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
164756009351	putative sugar binding site [chemical binding]; other site
164756009352	catalytic residues [active]
164756009353	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
164756009354	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
164756009355	putative dimer interface [polypeptide binding]; other site
164756009356	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756009357	ligand binding site [chemical binding]; other site
164756009358	Zn binding site [ion binding]; other site
164756009359	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756009360	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
164756009361	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
164756009362	dimer interface [polypeptide binding]; other site
164756009363	catalytic triad [active]
164756009364	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
164756009365	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
164756009366	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
164756009367	dimer interface [polypeptide binding]; other site
164756009368	TPP-binding site [chemical binding]; other site
164756009369	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
164756009370	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
164756009371	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
164756009372	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
164756009373	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
164756009374	acyl carrier protein; Provisional; Region: acpP; PRK00982
164756009375	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
164756009376	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
164756009377	dimer interface [polypeptide binding]; other site
164756009378	active site
164756009379	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
164756009380	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
164756009381	dimer interface [polypeptide binding]; other site
164756009382	active site
164756009383	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
164756009384	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
164756009385	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
164756009386	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756009387	Ligand Binding Site [chemical binding]; other site
164756009388	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
164756009389	Spore germination protein; Region: Spore_permease; cl17796
164756009390	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
164756009391	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756009392	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756009393	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
164756009394	FAD binding domain; Region: FAD_binding_4; pfam01565
164756009395	diacylglycerol kinase; Reviewed; Region: PRK11914
164756009396	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
164756009397	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
164756009398	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756009399	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756009400	Methyltransferase domain; Region: Methyltransf_31; pfam13847
164756009401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756009402	S-adenosylmethionine binding site [chemical binding]; other site
164756009403	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756009404	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756009405	DNA binding residues [nucleotide binding]
164756009406	dimerization interface [polypeptide binding]; other site
164756009407	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
164756009408	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
164756009409	NAD binding site [chemical binding]; other site
164756009410	catalytic Zn binding site [ion binding]; other site
164756009411	substrate binding site [chemical binding]; other site
164756009412	structural Zn binding site [ion binding]; other site
164756009413	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756009414	SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109
164756009415	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
164756009416	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
164756009417	conserved cys residue [active]
164756009418	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756009419	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756009420	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
164756009421	DJ-1 family protein; Region: not_thiJ; TIGR01383
164756009422	conserved cys residue [active]
164756009423	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756009424	nucleotide binding site [chemical binding]; other site
164756009425	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756009426	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756009427	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756009428	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
164756009429	classical (c) SDRs; Region: SDR_c; cd05233
164756009430	NAD(P) binding site [chemical binding]; other site
164756009431	active site
164756009432	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
164756009433	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
164756009434	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
164756009435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756009436	dimer interface [polypeptide binding]; other site
164756009437	conserved gate region; other site
164756009438	putative PBP binding loops; other site
164756009439	ABC-ATPase subunit interface; other site
164756009440	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
164756009441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756009442	putative PBP binding loops; other site
164756009443	dimer interface [polypeptide binding]; other site
164756009444	ABC-ATPase subunit interface; other site
164756009445	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
164756009446	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
164756009447	Walker A/P-loop; other site
164756009448	ATP binding site [chemical binding]; other site
164756009449	Q-loop/lid; other site
164756009450	ABC transporter signature motif; other site
164756009451	Walker B; other site
164756009452	D-loop; other site
164756009453	H-loop/switch region; other site
164756009454	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
164756009455	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
164756009456	Walker A/P-loop; other site
164756009457	ATP binding site [chemical binding]; other site
164756009458	Q-loop/lid; other site
164756009459	ABC transporter signature motif; other site
164756009460	Walker B; other site
164756009461	D-loop; other site
164756009462	H-loop/switch region; other site
164756009463	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756009464	classical (c) SDRs; Region: SDR_c; cd05233
164756009465	NAD(P) binding site [chemical binding]; other site
164756009466	active site
164756009467	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
164756009468	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756009469	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
164756009470	active site
164756009471	ATP binding site [chemical binding]; other site
164756009472	substrate binding site [chemical binding]; other site
164756009473	activation loop (A-loop); other site
164756009474	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
164756009475	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
164756009476	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
164756009477	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
164756009478	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
164756009479	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
164756009480	RNA binding site [nucleotide binding]; other site
164756009481	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
164756009482	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
164756009483	NAD binding site [chemical binding]; other site
164756009484	substrate binding site [chemical binding]; other site
164756009485	catalytic Zn binding site [ion binding]; other site
164756009486	structural Zn binding site [ion binding]; other site
164756009487	phosphoenolpyruvate synthase; Validated; Region: PRK06464
164756009488	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
164756009489	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
164756009490	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
164756009491	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756009492	active site
164756009493	motif I; other site
164756009494	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
164756009495	motif II; other site
164756009496	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
164756009497	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
164756009498	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
164756009499	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
164756009500	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
164756009501	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
164756009502	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756009503	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756009504	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756009505	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756009506	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
164756009507	dimer interface [polypeptide binding]; other site
164756009508	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756009509	Ligand Binding Site [chemical binding]; other site
164756009510	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756009511	Ligand Binding Site [chemical binding]; other site
164756009512	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
164756009513	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
164756009514	putative substrate binding site [chemical binding]; other site
164756009515	putative ATP binding site [chemical binding]; other site
164756009516	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
164756009517	active site
164756009518	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
164756009519	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
164756009520	active site
164756009521	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
164756009522	nickel binding site [ion binding]; other site
164756009523	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
164756009524	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
164756009525	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
164756009526	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
164756009527	FAD binding pocket [chemical binding]; other site
164756009528	FAD binding motif [chemical binding]; other site
164756009529	phosphate binding motif [ion binding]; other site
164756009530	beta-alpha-beta structure motif; other site
164756009531	NAD binding pocket [chemical binding]; other site
164756009532	Iron coordination center [ion binding]; other site
164756009533	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
164756009534	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
164756009535	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
164756009536	N-acetyl-D-glucosamine binding site [chemical binding]; other site
164756009537	catalytic residue [active]
164756009538	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
164756009539	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756009540	Cytochrome P450; Region: p450; cl12078
164756009541	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756009542	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756009543	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
164756009544	Uncharacterized conserved protein [Function unknown]; Region: COG2128
164756009545	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
164756009546	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
164756009547	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
164756009548	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
164756009549	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
164756009550	Walker A/P-loop; other site
164756009551	ATP binding site [chemical binding]; other site
164756009552	Q-loop/lid; other site
164756009553	ABC transporter signature motif; other site
164756009554	Walker B; other site
164756009555	D-loop; other site
164756009556	H-loop/switch region; other site
164756009557	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
164756009558	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
164756009559	Walker A/P-loop; other site
164756009560	ATP binding site [chemical binding]; other site
164756009561	Q-loop/lid; other site
164756009562	ABC transporter signature motif; other site
164756009563	Walker B; other site
164756009564	D-loop; other site
164756009565	H-loop/switch region; other site
164756009566	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756009567	MarR family; Region: MarR; pfam01047
164756009568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756009569	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756009570	putative substrate translocation pore; other site
164756009571	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
164756009572	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756009573	active site
164756009574	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
164756009575	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
164756009576	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
164756009577	D-pathway; other site
164756009578	Putative ubiquinol binding site [chemical binding]; other site
164756009579	Low-spin heme (heme b) binding site [chemical binding]; other site
164756009580	Putative water exit pathway; other site
164756009581	Binuclear center (heme o3/CuB) [ion binding]; other site
164756009582	K-pathway; other site
164756009583	Putative proton exit pathway; other site
164756009584	The Eukaryotic (Putative) Sterol Transporter (EST) Family; Region: 2A060602; TIGR00918
164756009585	DNA primase; Validated; Region: dnaG; PRK05667
164756009586	CHC2 zinc finger; Region: zf-CHC2; cl17510
164756009587	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
164756009588	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
164756009589	active site
164756009590	metal binding site [ion binding]; metal-binding site
164756009591	interdomain interaction site; other site
164756009592	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
164756009593	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
164756009594	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
164756009595	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
164756009596	Zn2+ binding site [ion binding]; other site
164756009597	Mg2+ binding site [ion binding]; other site
164756009598	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
164756009599	Repair protein; Region: Repair_PSII; pfam04536
164756009600	glycyl-tRNA synthetase; Provisional; Region: PRK04173
164756009601	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
164756009602	motif 1; other site
164756009603	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
164756009604	active site
164756009605	motif 2; other site
164756009606	motif 3; other site
164756009607	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
164756009608	anticodon binding site; other site
164756009609	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756009610	dimerization interface [polypeptide binding]; other site
164756009611	putative DNA binding site [nucleotide binding]; other site
164756009612	putative Zn2+ binding site [ion binding]; other site
164756009613	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
164756009614	metal binding site 2 [ion binding]; metal-binding site
164756009615	putative DNA binding helix; other site
164756009616	metal binding site 1 [ion binding]; metal-binding site
164756009617	dimer interface [polypeptide binding]; other site
164756009618	structural Zn2+ binding site [ion binding]; other site
164756009619	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
164756009620	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
164756009621	catalytic residue [active]
164756009622	putative FPP diphosphate  binding site; other site
164756009623	putative FPP binding hydrophobic cleft; other site
164756009624	dimer interface [polypeptide binding]; other site
164756009625	putative IPP diphosphate binding site; other site
164756009626	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
164756009627	Recombination protein O N terminal; Region: RecO_N; pfam11967
164756009628	Recombination protein O C terminal; Region: RecO_C; pfam02565
164756009629	amidase; Provisional; Region: PRK06061
164756009630	Amidase; Region: Amidase; pfam01425
164756009631	GTPase Era; Reviewed; Region: era; PRK00089
164756009632	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
164756009633	G1 box; other site
164756009634	GTP/Mg2+ binding site [chemical binding]; other site
164756009635	Switch I region; other site
164756009636	G2 box; other site
164756009637	Switch II region; other site
164756009638	G3 box; other site
164756009639	G4 box; other site
164756009640	G5 box; other site
164756009641	KH domain; Region: KH_2; pfam07650
164756009642	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
164756009643	Domain of unknown function DUF21; Region: DUF21; pfam01595
164756009644	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
164756009645	Transporter associated domain; Region: CorC_HlyC; smart01091
164756009646	metal-binding heat shock protein; Provisional; Region: PRK00016
164756009647	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
164756009648	PhoH-like protein; Region: PhoH; pfam02562
164756009649	Protein of unknown function (DUF998); Region: DUF998; pfam06197
164756009650	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
164756009651	chaperone protein DnaJ; Provisional; Region: PRK14278
164756009652	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
164756009653	HSP70 interaction site [polypeptide binding]; other site
164756009654	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
164756009655	Zn binding sites [ion binding]; other site
164756009656	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
164756009657	dimer interface [polypeptide binding]; other site
164756009658	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
164756009659	HTH domain; Region: HTH_11; cl17392
164756009660	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
164756009661	MbtH-like protein; Region: MbtH; pfam03621
164756009662	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756009663	Condensation domain; Region: Condensation; pfam00668
164756009664	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
164756009665	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
164756009666	acyl-activating enzyme (AAE) consensus motif; other site
164756009667	AMP binding site [chemical binding]; other site
164756009668	Condensation domain; Region: Condensation; pfam00668
164756009669	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
164756009670	Condensation domain; Region: Condensation; pfam00668
164756009671	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
164756009672	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
164756009673	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
164756009674	acyl-activating enzyme (AAE) consensus motif; other site
164756009675	AMP binding site [chemical binding]; other site
164756009676	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
164756009677	Condensation domain; Region: Condensation; pfam00668
164756009678	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
164756009679	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
164756009680	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756009681	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
164756009682	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756009683	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
164756009684	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
164756009685	NADP binding site [chemical binding]; other site
164756009686	active site
164756009687	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756009688	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756009689	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
164756009690	active site
164756009691	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
164756009692	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
164756009693	Condensation domain; Region: Condensation; pfam00668
164756009694	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
164756009695	Nonribosomal peptide synthase; Region: NRPS; pfam08415
164756009696	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
164756009697	acyl-activating enzyme (AAE) consensus motif; other site
164756009698	AMP binding site [chemical binding]; other site
164756009699	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
164756009700	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
164756009701	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
164756009702	acyl-activating enzyme (AAE) consensus motif; other site
164756009703	active site
164756009704	AMP binding site [chemical binding]; other site
164756009705	substrate binding site [chemical binding]; other site
164756009706	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
164756009707	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756009708	active site
164756009709	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756009710	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
164756009711	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
164756009712	KR domain; Region: KR; pfam08659
164756009713	putative NADP binding site [chemical binding]; other site
164756009714	active site
164756009715	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756009716	coproporphyrinogen III oxidase; Validated; Region: PRK05628
164756009717	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
164756009718	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
164756009719	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
164756009720	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
164756009721	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
164756009722	Active Sites [active]
164756009723	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
164756009724	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
164756009725	putative active site [active]
164756009726	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
164756009727	putative active site [active]
164756009728	Domain of unknown function DUF21; Region: DUF21; pfam01595
164756009729	FOG: CBS domain [General function prediction only]; Region: COG0517
164756009730	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
164756009731	Transporter associated domain; Region: CorC_HlyC; pfam03471
164756009732	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
164756009733	Domain of unknown function DUF21; Region: DUF21; pfam01595
164756009734	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
164756009735	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
164756009736	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
164756009737	Walker A/P-loop; other site
164756009738	ATP binding site [chemical binding]; other site
164756009739	Q-loop/lid; other site
164756009740	ABC transporter signature motif; other site
164756009741	Walker B; other site
164756009742	D-loop; other site
164756009743	H-loop/switch region; other site
164756009744	TOBE-like domain; Region: TOBE_3; pfam12857
164756009745	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
164756009746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756009747	dimer interface [polypeptide binding]; other site
164756009748	conserved gate region; other site
164756009749	putative PBP binding loops; other site
164756009750	ABC-ATPase subunit interface; other site
164756009751	sulfate transport protein; Provisional; Region: cysT; CHL00187
164756009752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756009753	dimer interface [polypeptide binding]; other site
164756009754	conserved gate region; other site
164756009755	putative PBP binding loops; other site
164756009756	ABC-ATPase subunit interface; other site
164756009757	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
164756009758	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
164756009759	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
164756009760	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
164756009761	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
164756009762	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
164756009763	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
164756009764	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756009765	active site
164756009766	Transcriptional regulator [Transcription]; Region: LysR; COG0583
164756009767	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756009768	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
164756009769	putative dimerization interface [polypeptide binding]; other site
164756009770	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
164756009771	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
164756009772	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
164756009773	PknH-like extracellular domain; Region: PknH_C; pfam14032
164756009774	PknH-like extracellular domain; Region: PknH_C; pfam14032
164756009775	GTP-binding protein LepA; Provisional; Region: PRK05433
164756009776	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
164756009777	G1 box; other site
164756009778	putative GEF interaction site [polypeptide binding]; other site
164756009779	GTP/Mg2+ binding site [chemical binding]; other site
164756009780	Switch I region; other site
164756009781	G2 box; other site
164756009782	G3 box; other site
164756009783	Switch II region; other site
164756009784	G4 box; other site
164756009785	G5 box; other site
164756009786	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
164756009787	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
164756009788	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
164756009789	PemK-like protein; Region: PemK; pfam02452
164756009790	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
164756009791	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
164756009792	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
164756009793	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
164756009794	active site
164756009795	dimer interface [polypeptide binding]; other site
164756009796	non-prolyl cis peptide bond; other site
164756009797	insertion regions; other site
164756009798	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756009799	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
164756009800	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
164756009801	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
164756009802	Walker A/P-loop; other site
164756009803	ATP binding site [chemical binding]; other site
164756009804	Q-loop/lid; other site
164756009805	ABC transporter signature motif; other site
164756009806	Walker B; other site
164756009807	D-loop; other site
164756009808	H-loop/switch region; other site
164756009809	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756009810	dimer interface [polypeptide binding]; other site
164756009811	conserved gate region; other site
164756009812	ABC-ATPase subunit interface; other site
164756009813	Transposase; Region: DEDD_Tnp_IS110; pfam01548
164756009814	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
164756009815	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
164756009816	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
164756009817	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
164756009818	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
164756009819	active site
164756009820	non-prolyl cis peptide bond; other site
164756009821	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
164756009822	ribonuclease Z; Reviewed; Region: PRK00055
164756009823	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
164756009824	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
164756009825	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
164756009826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
164756009827	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
164756009828	Uncharacterized conserved protein [Function unknown]; Region: COG2308
164756009829	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
164756009830	hypothetical protein; Reviewed; Region: PRK07914
164756009831	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
164756009832	Competence protein; Region: Competence; pfam03772
164756009833	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
164756009834	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
164756009835	polymerase nucleotide-binding site; other site
164756009836	DNA-binding residues [nucleotide binding]; DNA binding site
164756009837	nucleotide binding site [chemical binding]; other site
164756009838	primase nucleotide-binding site [nucleotide binding]; other site
164756009839	AAA domain; Region: AAA_25; pfam13481
164756009840	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
164756009841	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
164756009842	catalytic residues [active]
164756009843	catalytic nucleophile [active]
164756009844	Recombinase; Region: Recombinase; pfam07508
164756009845	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
164756009846	SLBB domain; Region: SLBB; pfam10531
164756009847	Helix-hairpin-helix motif; Region: HHH; pfam00633
164756009848	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
164756009849	homotrimer interaction site [polypeptide binding]; other site
164756009850	putative active site [active]
164756009851	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756009852	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756009853	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
164756009854	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
164756009855	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
164756009856	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
164756009857	putative hydrophobic ligand binding site [chemical binding]; other site
164756009858	CLM binding site; other site
164756009859	L1 loop; other site
164756009860	DNA binding site [nucleotide binding]
164756009861	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756009862	putative DNA binding site [nucleotide binding]; other site
164756009863	putative Zn2+ binding site [ion binding]; other site
164756009864	EDD domain protein, DegV family; Region: DegV; TIGR00762
164756009865	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
164756009866	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
164756009867	active site
164756009868	catalytic triad [active]
164756009869	oxyanion hole [active]
164756009870	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756009871	catalytic core [active]
164756009872	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
164756009873	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
164756009874	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
164756009875	active site
164756009876	(T/H)XGH motif; other site
164756009877	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
164756009878	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756009879	DNA-binding site [nucleotide binding]; DNA binding site
164756009880	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
164756009881	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
164756009882	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
164756009883	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756009884	nucleotide binding site [chemical binding]; other site
164756009885	Predicted dehydrogenase [General function prediction only]; Region: COG0579
164756009886	hydroxyglutarate oxidase; Provisional; Region: PRK11728
164756009887	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
164756009888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
164756009889	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
164756009890	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
164756009891	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
164756009892	metal ion-dependent adhesion site (MIDAS); other site
164756009893	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
164756009894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756009895	Walker A motif; other site
164756009896	ATP binding site [chemical binding]; other site
164756009897	Walker B motif; other site
164756009898	arginine finger; other site
164756009899	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
164756009900	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
164756009901	putative catalytic cysteine [active]
164756009902	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
164756009903	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
164756009904	substrate binding site [chemical binding]; other site
164756009905	dimer interface [polypeptide binding]; other site
164756009906	ATP binding site [chemical binding]; other site
164756009907	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756009908	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756009909	substrate binding site [chemical binding]; other site
164756009910	oxyanion hole (OAH) forming residues; other site
164756009911	trimer interface [polypeptide binding]; other site
164756009912	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756009913	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756009914	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
164756009915	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756009916	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756009917	active site
164756009918	NAD synthetase; Reviewed; Region: nadE; PRK02628
164756009919	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
164756009920	multimer interface [polypeptide binding]; other site
164756009921	active site
164756009922	catalytic triad [active]
164756009923	protein interface 1 [polypeptide binding]; other site
164756009924	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
164756009925	homodimer interface [polypeptide binding]; other site
164756009926	NAD binding pocket [chemical binding]; other site
164756009927	ATP binding pocket [chemical binding]; other site
164756009928	Mg binding site [ion binding]; other site
164756009929	active-site loop [active]
164756009930	Isochorismatase family; Region: Isochorismatase; pfam00857
164756009931	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
164756009932	catalytic triad [active]
164756009933	conserved cis-peptide bond; other site
164756009934	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
164756009935	NAD-dependent deacetylase; Provisional; Region: PRK05333
164756009936	NAD+ binding site [chemical binding]; other site
164756009937	substrate binding site [chemical binding]; other site
164756009938	Zn binding site [ion binding]; other site
164756009939	gamma-glutamyl kinase; Provisional; Region: PRK05429
164756009940	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
164756009941	nucleotide binding site [chemical binding]; other site
164756009942	homotetrameric interface [polypeptide binding]; other site
164756009943	putative phosphate binding site [ion binding]; other site
164756009944	putative allosteric binding site; other site
164756009945	PUA domain; Region: PUA; pfam01472
164756009946	GTPase CgtA; Reviewed; Region: obgE; PRK12296
164756009947	GTP1/OBG; Region: GTP1_OBG; pfam01018
164756009948	Obg GTPase; Region: Obg; cd01898
164756009949	G1 box; other site
164756009950	GTP/Mg2+ binding site [chemical binding]; other site
164756009951	Switch I region; other site
164756009952	G2 box; other site
164756009953	G3 box; other site
164756009954	Switch II region; other site
164756009955	G4 box; other site
164756009956	G5 box; other site
164756009957	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
164756009958	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
164756009959	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
164756009960	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
164756009961	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
164756009962	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
164756009963	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
164756009964	homodimer interface [polypeptide binding]; other site
164756009965	oligonucleotide binding site [chemical binding]; other site
164756009966	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
164756009967	active site
164756009968	multimer interface [polypeptide binding]; other site
164756009969	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756009970	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756009971	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
164756009972	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
164756009973	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
164756009974	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
164756009975	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
164756009976	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
164756009977	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
164756009978	active site
164756009979	HIGH motif; other site
164756009980	nucleotide binding site [chemical binding]; other site
164756009981	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
164756009982	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
164756009983	active site
164756009984	KMSKS motif; other site
164756009985	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
164756009986	tRNA binding surface [nucleotide binding]; other site
164756009987	anticodon binding site; other site
164756009988	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
164756009989	Uncharacterized conserved protein [Function unknown]; Region: COG3268
164756009990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756009991	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
164756009992	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
164756009993	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756009994	hypothetical protein; Provisional; Region: PRK06753
164756009995	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756009996	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
164756009997	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
164756009998	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
164756009999	GTP binding site; other site
164756010000	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
164756010001	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
164756010002	TPP-binding site [chemical binding]; other site
164756010003	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
164756010004	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
164756010005	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
164756010006	dimer interface [polypeptide binding]; other site
164756010007	PYR/PP interface [polypeptide binding]; other site
164756010008	TPP binding site [chemical binding]; other site
164756010009	substrate binding site [chemical binding]; other site
164756010010	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756010011	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756010012	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756010013	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
164756010014	[2Fe-2S] cluster binding site [ion binding]; other site
164756010015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
164756010016	Uncharacterized conserved protein [Function unknown]; Region: COG3391
164756010017	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
164756010018	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
164756010019	active site
164756010020	TDP-binding site; other site
164756010021	acceptor substrate-binding pocket; other site
164756010022	homodimer interface [polypeptide binding]; other site
164756010023	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
164756010024	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
164756010025	iron-sulfur cluster [ion binding]; other site
164756010026	[2Fe-2S] cluster binding site [ion binding]; other site
164756010027	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
164756010028	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
164756010029	putative di-iron ligands [ion binding]; other site
164756010030	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
164756010031	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
164756010032	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756010033	Walker A motif; other site
164756010034	ATP binding site [chemical binding]; other site
164756010035	Walker B motif; other site
164756010036	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
164756010037	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
164756010038	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
164756010039	oligomer interface [polypeptide binding]; other site
164756010040	active site residues [active]
164756010041	Clp protease; Region: CLP_protease; pfam00574
164756010042	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
164756010043	oligomer interface [polypeptide binding]; other site
164756010044	active site residues [active]
164756010045	trigger factor; Provisional; Region: tig; PRK01490
164756010046	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
164756010047	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
164756010048	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
164756010049	hypothetical protein; Provisional; Region: PRK07208
164756010050	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756010051	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
164756010052	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
164756010053	catalytic residue [active]
164756010054	putative FPP diphosphate  binding site; other site
164756010055	putative FPP binding hydrophobic cleft; other site
164756010056	dimer interface [polypeptide binding]; other site
164756010057	putative IPP diphosphate binding site; other site
164756010058	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
164756010059	Bacterial sugar transferase; Region: Bac_transf; pfam02397
164756010060	GAF domain; Region: GAF; pfam01590
164756010061	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
164756010062	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756010063	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
164756010064	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
164756010065	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
164756010066	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
164756010067	putative ADP-binding pocket [chemical binding]; other site
164756010068	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756010069	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
164756010070	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
164756010071	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
164756010072	putative [4Fe-4S] binding site [ion binding]; other site
164756010073	putative molybdopterin cofactor binding site [chemical binding]; other site
164756010074	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
164756010075	molybdopterin cofactor binding site; other site
164756010076	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756010077	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756010078	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
164756010079	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
164756010080	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
164756010081	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
164756010082	putative DNA binding site [nucleotide binding]; other site
164756010083	catalytic residue [active]
164756010084	putative H2TH interface [polypeptide binding]; other site
164756010085	putative catalytic residues [active]
164756010086	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
164756010087	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
164756010088	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
164756010089	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
164756010090	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
164756010091	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
164756010092	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
164756010093	nucleoside/Zn binding site; other site
164756010094	dimer interface [polypeptide binding]; other site
164756010095	catalytic motif [active]
164756010096	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
164756010097	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
164756010098	acyl-activating enzyme (AAE) consensus motif; other site
164756010099	putative AMP binding site [chemical binding]; other site
164756010100	putative active site [active]
164756010101	putative CoA binding site [chemical binding]; other site
164756010102	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
164756010103	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
164756010104	catalytic residues [active]
164756010105	N-formylglutamate amidohydrolase; Region: FGase; cl01522
164756010106	Protein of unknown function (DUF732); Region: DUF732; pfam05305
164756010107	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
164756010108	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
164756010109	Zn binding site [ion binding]; other site
164756010110	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756010111	active site
164756010112	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
164756010113	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756010114	active site
164756010115	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
164756010116	apolar tunnel; other site
164756010117	heme binding site [chemical binding]; other site
164756010118	dimerization interface [polypeptide binding]; other site
164756010119	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
164756010120	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
164756010121	active site
164756010122	catalytic site [active]
164756010123	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
164756010124	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
164756010125	active site
164756010126	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
164756010127	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
164756010128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756010129	Walker A/P-loop; other site
164756010130	ATP binding site [chemical binding]; other site
164756010131	Q-loop/lid; other site
164756010132	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756010133	ABC transporter; Region: ABC_tran_2; pfam12848
164756010134	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756010135	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
164756010136	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
164756010137	dimer interface [polypeptide binding]; other site
164756010138	ssDNA binding site [nucleotide binding]; other site
164756010139	tetramer (dimer of dimers) interface [polypeptide binding]; other site
164756010140	Copper resistance protein D; Region: CopD; pfam05425
164756010141	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
164756010142	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
164756010143	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
164756010144	putative acyl-acceptor binding pocket; other site
164756010145	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
164756010146	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
164756010147	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756010148	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
164756010149	putative acyl-acceptor binding pocket; other site
164756010150	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756010151	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756010152	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756010153	Ligand Binding Site [chemical binding]; other site
164756010154	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756010155	Ligand Binding Site [chemical binding]; other site
164756010156	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
164756010157	enoyl-CoA hydratase; Provisional; Region: PRK05870
164756010158	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756010159	substrate binding site [chemical binding]; other site
164756010160	oxyanion hole (OAH) forming residues; other site
164756010161	trimer interface [polypeptide binding]; other site
164756010162	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
164756010163	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
164756010164	E3 interaction surface; other site
164756010165	lipoyl attachment site [posttranslational modification]; other site
164756010166	e3 binding domain; Region: E3_binding; pfam02817
164756010167	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
164756010168	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
164756010169	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
164756010170	alpha subunit interface [polypeptide binding]; other site
164756010171	TPP binding site [chemical binding]; other site
164756010172	heterodimer interface [polypeptide binding]; other site
164756010173	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
164756010174	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
164756010175	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
164756010176	tetramer interface [polypeptide binding]; other site
164756010177	TPP-binding site [chemical binding]; other site
164756010178	heterodimer interface [polypeptide binding]; other site
164756010179	phosphorylation loop region [posttranslational modification]
164756010180	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
164756010181	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
164756010182	putative active site [active]
164756010183	putative catalytic site [active]
164756010184	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010185	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010186	active site
164756010187	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
164756010188	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
164756010189	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
164756010190	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
164756010191	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
164756010192	carboxyltransferase (CT) interaction site; other site
164756010193	biotinylation site [posttranslational modification]; other site
164756010194	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
164756010195	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
164756010196	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
164756010197	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010199	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756010200	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756010201	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
164756010202	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
164756010203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756010204	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
164756010205	classical (c) SDRs; Region: SDR_c; cd05233
164756010206	NAD(P) binding site [chemical binding]; other site
164756010207	active site
164756010208	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
164756010209	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756010210	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
164756010211	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
164756010212	catalytic site [active]
164756010213	putative active site [active]
164756010214	putative substrate binding site [chemical binding]; other site
164756010215	dimer interface [polypeptide binding]; other site
164756010216	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
164756010217	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
164756010218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
164756010219	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
164756010220	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
164756010221	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
164756010222	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
164756010223	catalytic triad [active]
164756010224	hypothetical protein; Provisional; Region: PRK07907
164756010225	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
164756010226	active site
164756010227	metal binding site [ion binding]; metal-binding site
164756010228	dimer interface [polypeptide binding]; other site
164756010229	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
164756010230	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
164756010231	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
164756010232	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
164756010233	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
164756010234	phosphate binding site [ion binding]; other site
164756010235	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
164756010236	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
164756010237	putative active site [active]
164756010238	putative catalytic site [active]
164756010239	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
164756010240	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
164756010241	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
164756010242	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
164756010243	putative NAD(P) binding site [chemical binding]; other site
164756010244	active site
164756010245	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
164756010246	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
164756010247	active site
164756010248	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
164756010249	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
164756010250	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756010251	DNA binding residues [nucleotide binding]
164756010252	putative dimer interface [polypeptide binding]; other site
164756010253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756010254	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756010255	putative substrate translocation pore; other site
164756010256	ChaB; Region: ChaB; pfam06150
164756010257	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
164756010258	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
164756010259	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
164756010260	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756010261	acyl-activating enzyme (AAE) consensus motif; other site
164756010262	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
164756010263	putative AMP binding site [chemical binding]; other site
164756010264	putative active site [active]
164756010265	acyl-activating enzyme (AAE) consensus motif; other site
164756010266	putative CoA binding site [chemical binding]; other site
164756010267	Amidohydrolase; Region: Amidohydro_2; pfam04909
164756010268	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
164756010269	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756010270	acyl-activating enzyme (AAE) consensus motif; other site
164756010271	AMP binding site [chemical binding]; other site
164756010272	active site
164756010273	CoA binding site [chemical binding]; other site
164756010274	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756010275	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756010276	substrate binding site [chemical binding]; other site
164756010277	oxyanion hole (OAH) forming residues; other site
164756010278	trimer interface [polypeptide binding]; other site
164756010279	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
164756010280	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756010281	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
164756010282	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756010283	active site
164756010284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010286	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756010287	Cytochrome P450; Region: p450; cl12078
164756010288	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756010289	mce related protein; Region: MCE; pfam02470
164756010290	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756010291	mce related protein; Region: MCE; pfam02470
164756010292	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756010293	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756010294	mce related protein; Region: MCE; pfam02470
164756010295	mce related protein; Region: MCE; pfam02470
164756010296	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756010297	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756010298	mce related protein; Region: MCE; pfam02470
164756010299	mce related protein; Region: MCE; pfam02470
164756010300	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756010301	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756010302	Permease; Region: Permease; pfam02405
164756010303	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756010304	Permease; Region: Permease; pfam02405
164756010305	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756010306	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756010307	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
164756010308	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
164756010309	NAD binding site [chemical binding]; other site
164756010310	catalytic residues [active]
164756010311	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756010312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756010313	NAD(P) binding site [chemical binding]; other site
164756010314	active site
164756010315	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756010316	classical (c) SDRs; Region: SDR_c; cd05233
164756010317	NAD(P) binding site [chemical binding]; other site
164756010318	active site
164756010319	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
164756010320	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756010321	Cytochrome P450; Region: p450; cl12078
164756010322	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010323	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010324	active site
164756010325	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010326	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756010327	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010328	Amidohydrolase; Region: Amidohydro_2; pfam04909
164756010329	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756010330	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756010331	iron-sulfur cluster [ion binding]; other site
164756010332	[2Fe-2S] cluster binding site [ion binding]; other site
164756010333	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756010334	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
164756010335	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
164756010336	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
164756010337	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
164756010338	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756010339	lipid-transfer protein; Provisional; Region: PRK07855
164756010340	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756010341	active site
164756010342	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756010343	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756010344	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
164756010345	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
164756010346	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756010347	Cytochrome P450; Region: p450; cl12078
164756010348	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756010349	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
164756010350	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756010351	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756010352	Cytochrome P450; Region: p450; cl12078
164756010353	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
164756010354	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756010355	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756010356	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
164756010357	[2Fe-2S] cluster binding site [ion binding]; other site
164756010358	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
164756010359	putative alpha subunit interface [polypeptide binding]; other site
164756010360	putative active site [active]
164756010361	putative substrate binding site [chemical binding]; other site
164756010362	Fe binding site [ion binding]; other site
164756010363	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010364	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010365	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
164756010366	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
164756010367	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756010368	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756010369	Cytochrome P450; Region: p450; cl12078
164756010370	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
164756010371	Uncharacterized conserved protein [Function unknown]; Region: COG2128
164756010372	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
164756010373	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
164756010374	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756010375	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
164756010376	[2Fe-2S] cluster binding site [ion binding]; other site
164756010377	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
164756010378	alpha subunit interface [polypeptide binding]; other site
164756010379	active site
164756010380	substrate binding site [chemical binding]; other site
164756010381	Fe binding site [ion binding]; other site
164756010382	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756010383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756010384	NAD(P) binding site [chemical binding]; other site
164756010385	active site
164756010386	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
164756010387	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
164756010388	FAD binding pocket [chemical binding]; other site
164756010389	FAD binding motif [chemical binding]; other site
164756010390	phosphate binding motif [ion binding]; other site
164756010391	beta-alpha-beta structure motif; other site
164756010392	NAD(p) ribose binding residues [chemical binding]; other site
164756010393	NAD binding pocket [chemical binding]; other site
164756010394	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
164756010395	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756010396	catalytic loop [active]
164756010397	iron binding site [ion binding]; other site
164756010398	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756010399	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
164756010400	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756010401	MarR family; Region: MarR_2; pfam12802
164756010402	MarR family; Region: MarR_2; cl17246
164756010403	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756010404	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
164756010405	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
164756010406	active site
164756010407	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756010408	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
164756010409	[2Fe-2S] cluster binding site [ion binding]; other site
164756010410	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
164756010411	alpha subunit interface [polypeptide binding]; other site
164756010412	active site
164756010413	substrate binding site [chemical binding]; other site
164756010414	Fe binding site [ion binding]; other site
164756010415	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
164756010416	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756010417	NAD binding site [chemical binding]; other site
164756010418	catalytic residues [active]
164756010419	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
164756010420	Winged helix-turn helix; Region: HTH_29; pfam13551
164756010421	Integrase core domain; Region: rve; pfam00665
164756010422	Integrase core domain; Region: rve_3; pfam13683
164756010423	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756010424	Cytochrome P450; Region: p450; cl12078
164756010425	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010426	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010427	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010428	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756010430	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
164756010431	Walker A motif; other site
164756010432	ATP binding site [chemical binding]; other site
164756010433	Walker B motif; other site
164756010434	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
164756010435	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
164756010436	metal ion-dependent adhesion site (MIDAS); other site
164756010437	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756010438	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
164756010439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756010440	NAD(P) binding site [chemical binding]; other site
164756010441	active site
164756010442	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
164756010443	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756010444	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756010445	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756010446	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756010447	active site
164756010448	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
164756010449	dimer interface [polypeptide binding]; other site
164756010450	substrate binding site [chemical binding]; other site
164756010451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010453	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010454	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010455	active site
164756010456	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
164756010457	putative active site [active]
164756010458	putative substrate binding site [chemical binding]; other site
164756010459	ATP binding site [chemical binding]; other site
164756010460	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
164756010461	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
164756010462	NAD(P) binding site [chemical binding]; other site
164756010463	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010464	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010465	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010466	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010467	active site
164756010468	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
164756010469	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756010470	dimer interface [polypeptide binding]; other site
164756010471	active site
164756010472	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756010473	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756010474	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756010475	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756010476	NAD(P) binding site [chemical binding]; other site
164756010477	active site
164756010478	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010479	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010480	active site
164756010481	Amidohydrolase; Region: Amidohydro_2; pfam04909
164756010482	Uncharacterized conserved protein [Function unknown]; Region: COG2128
164756010483	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
164756010484	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756010485	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
164756010486	[2Fe-2S] cluster binding site [ion binding]; other site
164756010487	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
164756010488	alpha subunit interface [polypeptide binding]; other site
164756010489	active site
164756010490	substrate binding site [chemical binding]; other site
164756010491	Fe binding site [ion binding]; other site
164756010492	Herpesvirus VP23 like capsid protein; Region: Herpes_V23; cl17653
164756010493	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
164756010494	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756010495	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
164756010496	active site
164756010497	SnoaL-like domain; Region: SnoaL_4; pfam13577
164756010498	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010499	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010500	active site
164756010501	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010502	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010503	enoyl-CoA hydratase; Provisional; Region: PRK08290
164756010504	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756010505	substrate binding site [chemical binding]; other site
164756010506	oxyanion hole (OAH) forming residues; other site
164756010507	trimer interface [polypeptide binding]; other site
164756010508	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010509	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010510	active site
164756010511	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010512	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010513	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
164756010514	classical (c) SDRs; Region: SDR_c; cd05233
164756010515	NAD(P) binding site [chemical binding]; other site
164756010516	active site
164756010517	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756010518	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756010519	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
164756010520	acyl-CoA synthetase; Provisional; Region: PRK13382
164756010521	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756010522	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756010523	acyl-activating enzyme (AAE) consensus motif; other site
164756010524	putative AMP binding site [chemical binding]; other site
164756010525	putative active site [active]
164756010526	putative CoA binding site [chemical binding]; other site
164756010527	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
164756010528	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756010529	putative acyl-acceptor binding pocket; other site
164756010530	extended (e) SDRs; Region: SDR_e; cd08946
164756010531	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
164756010532	NAD(P) binding site [chemical binding]; other site
164756010533	active site
164756010534	substrate binding site [chemical binding]; other site
164756010535	classical (c) SDRs; Region: SDR_c; cd05233
164756010536	NAD(P) binding site [chemical binding]; other site
164756010537	active site
164756010538	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756010539	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756010540	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756010541	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756010542	enoyl-CoA hydratase; Provisional; Region: PRK12478
164756010543	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756010544	substrate binding site [chemical binding]; other site
164756010545	oxyanion hole (OAH) forming residues; other site
164756010546	trimer interface [polypeptide binding]; other site
164756010547	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
164756010548	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
164756010549	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
164756010550	active site
164756010551	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
164756010552	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
164756010553	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
164756010554	active site
164756010555	Amidohydrolase; Region: Amidohydro_2; pfam04909
164756010556	Cytochrome P450; Region: p450; cl12078
164756010557	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756010558	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756010559	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
164756010560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756010563	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
164756010564	NAD(P) binding site [chemical binding]; other site
164756010565	active site
164756010566	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756010567	TAP-like protein; Region: Abhydrolase_4; pfam08386
164756010568	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
164756010569	Methyltransferase domain; Region: Methyltransf_26; pfam13659
164756010570	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
164756010571	oligomeric interface; other site
164756010572	putative active site [active]
164756010573	homodimer interface [polypeptide binding]; other site
164756010574	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
164756010575	GIY-YIG motif/motif A; other site
164756010576	putative active site [active]
164756010577	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
164756010578	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
164756010579	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
164756010580	DEAD-like helicases superfamily; Region: DEXDc; smart00487
164756010581	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756010582	ATP binding site [chemical binding]; other site
164756010583	putative Mg++ binding site [ion binding]; other site
164756010584	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
164756010585	nucleotide binding region [chemical binding]; other site
164756010586	ATP-binding site [chemical binding]; other site
164756010587	Predicted flavoprotein [General function prediction only]; Region: COG0431
164756010588	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
164756010589	Putative cyclase; Region: Cyclase; pfam04199
164756010590	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756010591	NAD(P) binding site [chemical binding]; other site
164756010592	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
164756010593	active site
164756010594	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
164756010595	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
164756010596	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
164756010597	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756010598	3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370
164756010599	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
164756010600	active site
164756010601	metal binding site [ion binding]; metal-binding site
164756010602	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
164756010603	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756010604	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756010605	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756010606	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
164756010607	Transcriptional regulator [Transcription]; Region: IclR; COG1414
164756010608	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
164756010609	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
164756010610	L-aspartate oxidase; Provisional; Region: PRK06175
164756010611	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756010612	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
164756010613	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
164756010614	Subunit I/III interface [polypeptide binding]; other site
164756010615	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010616	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010617	LAO/AO transport system ATPase; Region: lao; TIGR00750
164756010618	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756010619	putative acyltransferase; Provisional; Region: PRK05790
164756010620	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756010621	dimer interface [polypeptide binding]; other site
164756010622	active site
164756010623	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756010624	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
164756010625	NAD(P) binding site [chemical binding]; other site
164756010626	active site
164756010627	short chain dehydrogenase; Provisional; Region: PRK08278
164756010628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756010629	NAD(P) binding site [chemical binding]; other site
164756010630	active site
164756010631	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
164756010632	active site
164756010633	Trp repressor protein; Region: Trp_repressor; cl17266
164756010634	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
164756010635	Phage capsid family; Region: Phage_capsid; pfam05065
164756010636	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
164756010637	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
164756010638	GIY-YIG motif/motif A; other site
164756010639	active site
164756010640	catalytic site [active]
164756010641	metal binding site [ion binding]; metal-binding site
164756010642	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
164756010643	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
164756010644	catalytic residues [active]
164756010645	catalytic nucleophile [active]
164756010646	Recombinase; Region: Recombinase; pfam07508
164756010647	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
164756010648	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756010649	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756010650	substrate binding site [chemical binding]; other site
164756010651	oxyanion hole (OAH) forming residues; other site
164756010652	trimer interface [polypeptide binding]; other site
164756010653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010654	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010655	active site
164756010656	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756010657	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756010658	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
164756010659	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756010660	acyl-activating enzyme (AAE) consensus motif; other site
164756010661	AMP binding site [chemical binding]; other site
164756010662	active site
164756010663	CoA binding site [chemical binding]; other site
164756010664	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756010665	catalytic loop [active]
164756010666	iron binding site [ion binding]; other site
164756010667	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756010668	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756010669	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
164756010670	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756010671	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
164756010672	B12 binding site [chemical binding]; other site
164756010673	cobalt ligand [ion binding]; other site
164756010674	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
164756010675	short chain dehydrogenase; Provisional; Region: PRK08278
164756010676	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756010677	NAD(P) binding site [chemical binding]; other site
164756010678	active site
164756010679	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
164756010680	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756010681	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756010682	acyl-activating enzyme (AAE) consensus motif; other site
164756010683	acyl-activating enzyme (AAE) consensus motif; other site
164756010684	AMP binding site [chemical binding]; other site
164756010685	active site
164756010686	CoA binding site [chemical binding]; other site
164756010687	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756010688	dimerization interface [polypeptide binding]; other site
164756010689	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756010690	cyclase homology domain; Region: CHD; cd07302
164756010691	nucleotidyl binding site; other site
164756010692	metal binding site [ion binding]; metal-binding site
164756010693	dimer interface [polypeptide binding]; other site
164756010694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756010695	metabolite-proton symporter; Region: 2A0106; TIGR00883
164756010696	putative substrate translocation pore; other site
164756010697	metabolite-proton symporter; Region: 2A0106; TIGR00883
164756010698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756010699	putative substrate translocation pore; other site
164756010700	Phosphotransferase enzyme family; Region: APH; pfam01636
164756010701	Ecdysteroid kinase; Region: EcKinase; cl17738
164756010702	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756010703	Cytochrome P450; Region: p450; cl12078
164756010704	Transcriptional regulators [Transcription]; Region: PurR; COG1609
164756010705	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
164756010706	DNA binding site [nucleotide binding]
164756010707	domain linker motif; other site
164756010708	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
164756010709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756010710	metabolite-proton symporter; Region: 2A0106; TIGR00883
164756010711	putative substrate translocation pore; other site
164756010712	Domain of unknown function (DUF309); Region: DUF309; pfam03745
164756010713	Predicted membrane protein [Function unknown]; Region: COG4270
164756010714	Glucitol operon activator protein (GutM); Region: GutM; cl01890
164756010715	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
164756010716	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756010717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756010718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756010719	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756010720	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
164756010721	active site
164756010722	dimerization interface [polypeptide binding]; other site
164756010723	ribonuclease PH; Reviewed; Region: rph; PRK00173
164756010724	Ribonuclease PH; Region: RNase_PH_bact; cd11362
164756010725	hexamer interface [polypeptide binding]; other site
164756010726	active site
164756010727	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
164756010728	glutamate racemase; Provisional; Region: PRK00865
164756010729	Rhomboid family; Region: Rhomboid; pfam01694
164756010730	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
164756010731	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
164756010732	dimer interface [polypeptide binding]; other site
164756010733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756010734	catalytic residue [active]
164756010735	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
164756010736	MoaE interaction surface [polypeptide binding]; other site
164756010737	MoeB interaction surface [polypeptide binding]; other site
164756010738	thiocarboxylated glycine; other site
164756010739	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
164756010740	MPN+ (JAMM) motif; other site
164756010741	Zinc-binding site [ion binding]; other site
164756010742	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
164756010743	putative active site pocket [active]
164756010744	cleavage site
164756010745	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
164756010746	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
164756010747	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
164756010748	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
164756010749	active site
164756010750	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
164756010751	DEAD/DEAH box helicase; Region: DEAD; pfam00270
164756010752	DEAD_2; Region: DEAD_2; pfam06733
164756010753	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
164756010754	Predicted metalloprotease [General function prediction only]; Region: COG2321
164756010755	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
164756010756	MspA; Region: MspA; pfam09203
164756010757	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
164756010758	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
164756010759	putative homodimer interface [polypeptide binding]; other site
164756010760	putative active site pocket [active]
164756010761	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
164756010762	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
164756010763	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
164756010764	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
164756010765	active site
164756010766	homodimer interface [polypeptide binding]; other site
164756010767	catalytic site [active]
164756010768	acceptor binding site [chemical binding]; other site
164756010769	glycogen branching enzyme; Provisional; Region: PRK05402
164756010770	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
164756010771	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
164756010772	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
164756010773	active site
164756010774	catalytic site [active]
164756010775	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
164756010776	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
164756010777	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
164756010778	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
164756010779	putative acyltransferase; Provisional; Region: PRK05790
164756010780	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756010781	dimer interface [polypeptide binding]; other site
164756010782	active site
164756010783	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
164756010784	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756010785	dimer interface [polypeptide binding]; other site
164756010786	substrate binding site [chemical binding]; other site
164756010787	metal binding site [ion binding]; metal-binding site
164756010788	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
164756010789	hypothetical protein; Provisional; Region: PRK03298
164756010790	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
164756010791	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756010792	dimerization interface [polypeptide binding]; other site
164756010793	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756010794	cyclase homology domain; Region: CHD; cd07302
164756010795	nucleotidyl binding site; other site
164756010796	metal binding site [ion binding]; metal-binding site
164756010797	dimer interface [polypeptide binding]; other site
164756010798	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
164756010799	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
164756010800	acyl-activating enzyme (AAE) consensus motif; other site
164756010801	active site
164756010802	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
164756010803	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
164756010804	AlkA N-terminal domain; Region: AlkA_N; pfam06029
164756010805	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
164756010806	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
164756010807	minor groove reading motif; other site
164756010808	helix-hairpin-helix signature motif; other site
164756010809	substrate binding pocket [chemical binding]; other site
164756010810	active site
164756010811	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
164756010812	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
164756010813	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
164756010814	DNA binding site [nucleotide binding]
164756010815	active site
164756010816	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
164756010817	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
164756010818	hinge; other site
164756010819	active site
164756010820	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
164756010821	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
164756010822	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
164756010823	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
164756010824	gamma subunit interface [polypeptide binding]; other site
164756010825	epsilon subunit interface [polypeptide binding]; other site
164756010826	LBP interface [polypeptide binding]; other site
164756010827	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
164756010828	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
164756010829	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
164756010830	alpha subunit interaction interface [polypeptide binding]; other site
164756010831	Walker A motif; other site
164756010832	ATP binding site [chemical binding]; other site
164756010833	Walker B motif; other site
164756010834	inhibitor binding site; inhibition site
164756010835	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
164756010836	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
164756010837	core domain interface [polypeptide binding]; other site
164756010838	delta subunit interface [polypeptide binding]; other site
164756010839	epsilon subunit interface [polypeptide binding]; other site
164756010840	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
164756010841	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
164756010842	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
164756010843	beta subunit interaction interface [polypeptide binding]; other site
164756010844	Walker A motif; other site
164756010845	ATP binding site [chemical binding]; other site
164756010846	Walker B motif; other site
164756010847	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
164756010848	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
164756010849	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
164756010850	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
164756010851	ATP synthase CF0 B' subunit; Validated; Region: atpG; CHL00118
164756010852	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
164756010853	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
164756010854	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
164756010855	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
164756010856	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
164756010857	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
164756010858	Mg++ binding site [ion binding]; other site
164756010859	putative catalytic motif [active]
164756010860	substrate binding site [chemical binding]; other site
164756010861	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
164756010862	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
164756010863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756010864	S-adenosylmethionine binding site [chemical binding]; other site
164756010865	peptide chain release factor 1; Validated; Region: prfA; PRK00591
164756010866	This domain is found in peptide chain release factors; Region: PCRF; smart00937
164756010867	RF-1 domain; Region: RF-1; pfam00472
164756010868	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
164756010869	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
164756010870	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
164756010871	MarR family; Region: MarR_2; pfam12802
164756010872	acyl-CoA synthetase; Provisional; Region: PRK13388
164756010873	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756010874	acyl-activating enzyme (AAE) consensus motif; other site
164756010875	AMP binding site [chemical binding]; other site
164756010876	active site
164756010877	CoA binding site [chemical binding]; other site
164756010878	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756010879	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756010880	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
164756010881	transcription termination factor Rho; Provisional; Region: PRK12608
164756010882	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
164756010883	RNA binding site [nucleotide binding]; other site
164756010884	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
164756010885	multimer interface [polypeptide binding]; other site
164756010886	Walker A motif; other site
164756010887	ATP binding site [chemical binding]; other site
164756010888	Walker B motif; other site
164756010889	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
164756010890	threonine synthase; Reviewed; Region: PRK06721
164756010891	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
164756010892	homodimer interface [polypeptide binding]; other site
164756010893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756010894	catalytic residue [active]
164756010895	homoserine dehydrogenase; Provisional; Region: PRK06349
164756010896	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
164756010897	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
164756010898	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
164756010899	diaminopimelate decarboxylase; Region: lysA; TIGR01048
164756010900	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
164756010901	active site
164756010902	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
164756010903	substrate binding site [chemical binding]; other site
164756010904	catalytic residues [active]
164756010905	dimer interface [polypeptide binding]; other site
164756010906	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
164756010907	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
164756010908	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
164756010909	active site
164756010910	HIGH motif; other site
164756010911	KMSK motif region; other site
164756010912	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
164756010913	tRNA binding surface [nucleotide binding]; other site
164756010914	anticodon binding site; other site
164756010915	MASE1; Region: MASE1; cl17823
164756010916	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
164756010917	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
164756010918	putative NAD(P) binding site [chemical binding]; other site
164756010919	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
164756010920	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
164756010921	Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635
164756010922	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
164756010923	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756010924	putative ADP-binding pocket [chemical binding]; other site
164756010925	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
164756010926	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756010927	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
164756010928	Putative sensor; Region: Sensor; pfam13796
164756010929	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
164756010930	Histidine kinase; Region: HisKA_3; pfam07730
164756010931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756010932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756010933	active site
164756010934	phosphorylation site [posttranslational modification]
164756010935	intermolecular recognition site; other site
164756010936	dimerization interface [polypeptide binding]; other site
164756010937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756010938	DNA binding residues [nucleotide binding]
164756010939	dimerization interface [polypeptide binding]; other site
164756010940	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
164756010941	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756010942	metal binding site [ion binding]; metal-binding site
164756010943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756010944	metabolite-proton symporter; Region: 2A0106; TIGR00883
164756010945	putative substrate translocation pore; other site
164756010946	Uncharacterized conserved protein [Function unknown]; Region: COG2966
164756010947	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
164756010948	Rrf2 family protein; Region: rrf2_super; TIGR00738
164756010949	Transcriptional regulator; Region: Rrf2; pfam02082
164756010950	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
164756010951	Isochorismatase family; Region: Isochorismatase; pfam00857
164756010952	catalytic triad [active]
164756010953	conserved cis-peptide bond; other site
164756010954	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
164756010955	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
164756010956	active site
164756010957	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
164756010958	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
164756010959	CysD dimerization site [polypeptide binding]; other site
164756010960	G1 box; other site
164756010961	putative GEF interaction site [polypeptide binding]; other site
164756010962	GTP/Mg2+ binding site [chemical binding]; other site
164756010963	Switch I region; other site
164756010964	G2 box; other site
164756010965	G3 box; other site
164756010966	Switch II region; other site
164756010967	G4 box; other site
164756010968	G5 box; other site
164756010969	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
164756010970	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
164756010971	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
164756010972	ligand-binding site [chemical binding]; other site
164756010973	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
164756010974	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
164756010975	Active Sites [active]
164756010976	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756010977	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756010978	active site
164756010979	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
164756010980	active site clefts [active]
164756010981	zinc binding site [ion binding]; other site
164756010982	dimer interface [polypeptide binding]; other site
164756010983	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
164756010984	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
164756010985	Ligand binding site; other site
164756010986	Ligand binding site; other site
164756010987	Ligand binding site; other site
164756010988	Putative Catalytic site; other site
164756010989	DXD motif; other site
164756010990	Predicted membrane protein [Function unknown]; Region: COG2246
164756010991	GtrA-like protein; Region: GtrA; pfam04138
164756010992	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
164756010993	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
164756010994	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756010995	HAMP domain; Region: HAMP; pfam00672
164756010996	dimerization interface [polypeptide binding]; other site
164756010997	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756010998	dimer interface [polypeptide binding]; other site
164756010999	phosphorylation site [posttranslational modification]
164756011000	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756011001	ATP binding site [chemical binding]; other site
164756011002	Mg2+ binding site [ion binding]; other site
164756011003	G-X-G motif; other site
164756011004	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756011005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756011006	active site
164756011007	phosphorylation site [posttranslational modification]
164756011008	intermolecular recognition site; other site
164756011009	dimerization interface [polypeptide binding]; other site
164756011010	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756011011	DNA binding site [nucleotide binding]
164756011012	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
164756011013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756011014	putative PBP binding loops; other site
164756011015	dimer interface [polypeptide binding]; other site
164756011016	ABC-ATPase subunit interface; other site
164756011017	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
164756011018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756011019	dimer interface [polypeptide binding]; other site
164756011020	conserved gate region; other site
164756011021	putative PBP binding loops; other site
164756011022	ABC-ATPase subunit interface; other site
164756011023	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
164756011024	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
164756011025	Walker A/P-loop; other site
164756011026	ATP binding site [chemical binding]; other site
164756011027	Q-loop/lid; other site
164756011028	ABC transporter signature motif; other site
164756011029	Walker B; other site
164756011030	D-loop; other site
164756011031	H-loop/switch region; other site
164756011032	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
164756011033	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
164756011034	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
164756011035	Walker A/P-loop; other site
164756011036	ATP binding site [chemical binding]; other site
164756011037	Q-loop/lid; other site
164756011038	ABC transporter signature motif; other site
164756011039	Walker B; other site
164756011040	D-loop; other site
164756011041	H-loop/switch region; other site
164756011042	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
164756011043	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
164756011044	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
164756011045	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756011046	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
164756011047	active site
164756011048	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756011049	Walker A/P-loop; other site
164756011050	ATP binding site [chemical binding]; other site
164756011051	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
164756011052	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
164756011053	active site
164756011054	metal binding site [ion binding]; metal-binding site
164756011055	DNA binding site [nucleotide binding]
164756011056	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756011057	catalytic core [active]
164756011058	leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011
164756011059	Winged helix-turn helix; Region: HTH_29; pfam13551
164756011060	Integrase core domain; Region: rve; pfam00665
164756011061	Integrase core domain; Region: rve_3; pfam13683
164756011062	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
164756011063	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
164756011064	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
164756011065	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
164756011066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756011067	Walker A/P-loop; other site
164756011068	ATP binding site [chemical binding]; other site
164756011069	Q-loop/lid; other site
164756011070	ABC transporter signature motif; other site
164756011071	Walker B; other site
164756011072	D-loop; other site
164756011073	H-loop/switch region; other site
164756011074	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
164756011075	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
164756011076	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
164756011077	Walker A/P-loop; other site
164756011078	ATP binding site [chemical binding]; other site
164756011079	Q-loop/lid; other site
164756011080	ABC transporter signature motif; other site
164756011081	Walker B; other site
164756011082	D-loop; other site
164756011083	H-loop/switch region; other site
164756011084	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
164756011085	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756011086	molybdopterin cofactor binding site; other site
164756011087	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
164756011088	molybdopterin cofactor binding site; other site
164756011089	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
164756011090	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
164756011091	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
164756011092	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756011093	acyl-activating enzyme (AAE) consensus motif; other site
164756011094	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756011095	AMP binding site [chemical binding]; other site
164756011096	active site
164756011097	acyl-activating enzyme (AAE) consensus motif; other site
164756011098	CoA binding site [chemical binding]; other site
164756011099	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
164756011100	metal-binding site [ion binding]
164756011101	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
164756011102	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
164756011103	metal-binding site [ion binding]
164756011104	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756011105	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756011106	cyclase homology domain; Region: CHD; cd07302
164756011107	nucleotidyl binding site; other site
164756011108	metal binding site [ion binding]; metal-binding site
164756011109	dimer interface [polypeptide binding]; other site
164756011110	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
164756011111	putative active site [active]
164756011112	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756011113	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756011114	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
164756011115	putative dimer interface [polypeptide binding]; other site
164756011116	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756011117	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
164756011118	HIT family signature motif; other site
164756011119	catalytic residue [active]
164756011120	Domain of unknown function (DUF385); Region: DUF385; pfam04075
164756011121	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
164756011122	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756011123	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
164756011124	Fe-S cluster binding site [ion binding]; other site
164756011125	DNA binding site [nucleotide binding]
164756011126	active site
164756011127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756011128	H+ Antiporter protein; Region: 2A0121; TIGR00900
164756011129	putative substrate translocation pore; other site
164756011130	Predicted transcriptional regulators [Transcription]; Region: COG1733
164756011131	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
164756011132	SCP-2 sterol transfer family; Region: SCP2; cl01225
164756011133	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
164756011134	FAD binding domain; Region: FAD_binding_4; pfam01565
164756011135	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
164756011136	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756011137	Cytochrome P450; Region: p450; cl12078
164756011138	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756011139	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756011140	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
164756011141	Sulfatase; Region: Sulfatase; pfam00884
164756011142	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
164756011143	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
164756011144	FAD binding pocket [chemical binding]; other site
164756011145	FAD binding motif [chemical binding]; other site
164756011146	phosphate binding motif [ion binding]; other site
164756011147	NAD binding pocket [chemical binding]; other site
164756011148	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756011149	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
164756011150	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
164756011151	ATP binding site [chemical binding]; other site
164756011152	Mg++ binding site [ion binding]; other site
164756011153	motif III; other site
164756011154	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756011155	nucleotide binding region [chemical binding]; other site
164756011156	ATP-binding site [chemical binding]; other site
164756011157	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
164756011158	putative RNA binding site [nucleotide binding]; other site
164756011159	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
164756011160	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
164756011161	RNase_H superfamily; Region: RNase_H_2; pfam13482
164756011162	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
164756011163	Part of AAA domain; Region: AAA_19; pfam13245
164756011164	AAA domain; Region: AAA_12; pfam13087
164756011165	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756011166	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756011167	putative substrate translocation pore; other site
164756011168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756011169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756011170	putative substrate translocation pore; other site
164756011171	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
164756011172	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
164756011173	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
164756011174	TPP-binding site [chemical binding]; other site
164756011175	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
164756011176	Protein of unknown function (DUF732); Region: DUF732; pfam05305
164756011177	short chain dehydrogenase; Provisional; Region: PRK07832
164756011178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756011179	NAD(P) binding site [chemical binding]; other site
164756011180	active site
164756011181	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
164756011182	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
164756011183	Malic enzyme, N-terminal domain; Region: malic; pfam00390
164756011184	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
164756011185	putative NAD(P) binding site [chemical binding]; other site
164756011186	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
164756011187	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
164756011188	oligomer interface [polypeptide binding]; other site
164756011189	metal binding site [ion binding]; metal-binding site
164756011190	metal binding site [ion binding]; metal-binding site
164756011191	putative Cl binding site [ion binding]; other site
164756011192	basic sphincter; other site
164756011193	hydrophobic gate; other site
164756011194	periplasmic entrance; other site
164756011195	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
164756011196	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
164756011197	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
164756011198	Walker A/P-loop; other site
164756011199	ATP binding site [chemical binding]; other site
164756011200	Q-loop/lid; other site
164756011201	ABC transporter signature motif; other site
164756011202	Walker B; other site
164756011203	D-loop; other site
164756011204	H-loop/switch region; other site
164756011205	TOBE domain; Region: TOBE_2; pfam08402
164756011206	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
164756011207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756011208	dimer interface [polypeptide binding]; other site
164756011209	conserved gate region; other site
164756011210	putative PBP binding loops; other site
164756011211	ABC-ATPase subunit interface; other site
164756011212	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
164756011213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756011214	dimer interface [polypeptide binding]; other site
164756011215	conserved gate region; other site
164756011216	putative PBP binding loops; other site
164756011217	ABC-ATPase subunit interface; other site
164756011218	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
164756011219	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
164756011220	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
164756011221	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
164756011222	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
164756011223	MgtE intracellular N domain; Region: MgtE_N; smart00924
164756011224	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
164756011225	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
164756011226	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
164756011227	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
164756011228	N-acetyl-D-glucosamine binding site [chemical binding]; other site
164756011229	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
164756011230	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
164756011231	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
164756011232	sec-independent translocase; Provisional; Region: PRK03100
164756011233	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
164756011234	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
164756011235	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
164756011236	protein binding site [polypeptide binding]; other site
164756011237	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
164756011238	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
164756011239	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756011240	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756011241	DNA binding residues [nucleotide binding]
164756011242	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
164756011243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756011244	S-adenosylmethionine binding site [chemical binding]; other site
164756011245	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756011246	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756011247	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
164756011248	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
164756011249	Walker A/P-loop; other site
164756011250	ATP binding site [chemical binding]; other site
164756011251	Q-loop/lid; other site
164756011252	ABC transporter signature motif; other site
164756011253	Walker B; other site
164756011254	D-loop; other site
164756011255	H-loop/switch region; other site
164756011256	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
164756011257	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
164756011258	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
164756011259	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
164756011260	ligand binding site; other site
164756011261	oligomer interface; other site
164756011262	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
164756011263	dimer interface [polypeptide binding]; other site
164756011264	N-terminal domain interface [polypeptide binding]; other site
164756011265	sulfate 1 binding site; other site
164756011266	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
164756011267	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
164756011268	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
164756011269	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
164756011270	DivIVA domain; Region: DivI1A_domain; TIGR03544
164756011271	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
164756011272	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
164756011273	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
164756011274	dihydropteroate synthase; Region: DHPS; TIGR01496
164756011275	substrate binding pocket [chemical binding]; other site
164756011276	dimer interface [polypeptide binding]; other site
164756011277	inhibitor binding site; inhibition site
164756011278	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
164756011279	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
164756011280	acyl-activating enzyme (AAE) consensus motif; other site
164756011281	putative AMP binding site [chemical binding]; other site
164756011282	putative active site [active]
164756011283	putative CoA binding site [chemical binding]; other site
164756011284	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
164756011285	AAA domain; Region: AAA_22; pfam13401
164756011286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756011287	Walker A motif; other site
164756011288	ATP binding site [chemical binding]; other site
164756011289	Walker B motif; other site
164756011290	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
164756011291	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
164756011292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756011293	Walker A/P-loop; other site
164756011294	ATP binding site [chemical binding]; other site
164756011295	Q-loop/lid; other site
164756011296	ABC transporter signature motif; other site
164756011297	Walker B; other site
164756011298	D-loop; other site
164756011299	H-loop/switch region; other site
164756011300	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756011301	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
164756011302	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
164756011303	metal binding site [ion binding]; metal-binding site
164756011304	putative dimer interface [polypeptide binding]; other site
164756011305	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
164756011306	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
164756011307	putative trimer interface [polypeptide binding]; other site
164756011308	putative CoA binding site [chemical binding]; other site
164756011309	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
164756011310	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
164756011311	active site residue [active]
164756011312	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
164756011313	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
164756011314	putative homodimer interface [polypeptide binding]; other site
164756011315	putative homotetramer interface [polypeptide binding]; other site
164756011316	putative allosteric switch controlling residues; other site
164756011317	putative metal binding site [ion binding]; other site
164756011318	putative homodimer-homodimer interface [polypeptide binding]; other site
164756011319	Domain of unknown function DUF302; Region: DUF302; cl01364
164756011320	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
164756011321	acyl-CoA synthetase; Validated; Region: PRK07787
164756011322	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756011323	acyl-activating enzyme (AAE) consensus motif; other site
164756011324	AMP binding site [chemical binding]; other site
164756011325	active site
164756011326	CoA binding site [chemical binding]; other site
164756011327	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
164756011328	dimer interface [polypeptide binding]; other site
164756011329	ADP-ribose binding site [chemical binding]; other site
164756011330	active site
164756011331	nudix motif; other site
164756011332	metal binding site [ion binding]; metal-binding site
164756011333	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756011334	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
164756011335	SnoaL-like domain; Region: SnoaL_3; pfam13474
164756011336	Proline dehydrogenase; Region: Pro_dh; cl03282
164756011337	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
164756011338	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
164756011339	Glutamate binding site [chemical binding]; other site
164756011340	NAD binding site [chemical binding]; other site
164756011341	catalytic residues [active]
164756011342	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
164756011343	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
164756011344	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756011345	active site
164756011346	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756011347	succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539
164756011348	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756011349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756011350	homodimer interface [polypeptide binding]; other site
164756011351	catalytic residue [active]
164756011352	Ferredoxin [Energy production and conversion]; Region: COG1146
164756011353	4Fe-4S binding domain; Region: Fer4; pfam00037
164756011354	Uncharacterized conserved protein [Function unknown]; Region: COG2353
164756011355	FO synthase; Reviewed; Region: fbiC; PRK09234
164756011356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756011357	FeS/SAM binding site; other site
164756011358	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756011359	FeS/SAM binding site; other site
164756011360	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
164756011361	Homeodomain-like domain; Region: HTH_23; pfam13384
164756011362	Helix-turn-helix domain; Region: HTH_38; pfam13936
164756011363	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
164756011364	Integrase core domain; Region: rve; pfam00665
164756011365	putative minor structural protein; Region: PHA01351
164756011366	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
164756011367	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
164756011368	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
164756011369	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
164756011370	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
164756011371	G1 box; other site
164756011372	putative GEF interaction site [polypeptide binding]; other site
164756011373	GTP/Mg2+ binding site [chemical binding]; other site
164756011374	Switch I region; other site
164756011375	G2 box; other site
164756011376	G3 box; other site
164756011377	Switch II region; other site
164756011378	G4 box; other site
164756011379	G5 box; other site
164756011380	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
164756011381	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
164756011382	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
164756011383	active site
164756011384	8-oxo-dGMP binding site [chemical binding]; other site
164756011385	nudix motif; other site
164756011386	metal binding site [ion binding]; metal-binding site
164756011387	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
164756011388	aromatic arch; other site
164756011389	DCoH dimer interaction site [polypeptide binding]; other site
164756011390	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
164756011391	DCoH tetramer interaction site [polypeptide binding]; other site
164756011392	substrate binding site [chemical binding]; other site
164756011393	mannosyltransferase; Provisional; Region: pimE; PRK13375
164756011394	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
164756011395	uncharacterized HhH-GPD family protein; Region: TIGR03252
164756011396	minor groove reading motif; other site
164756011397	helix-hairpin-helix signature motif; other site
164756011398	Histidine kinase; Region: His_kinase; pfam06580
164756011399	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756011400	ATP binding site [chemical binding]; other site
164756011401	Mg2+ binding site [ion binding]; other site
164756011402	G-X-G motif; other site
164756011403	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
164756011404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756011405	active site
164756011406	phosphorylation site [posttranslational modification]
164756011407	intermolecular recognition site; other site
164756011408	dimerization interface [polypeptide binding]; other site
164756011409	LytTr DNA-binding domain; Region: LytTR; smart00850
164756011410	Protein of unknown function, DUF485; Region: DUF485; pfam04341
164756011411	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
164756011412	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
164756011413	Protein of unknown function, DUF485; Region: DUF485; pfam04341
164756011414	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
164756011415	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
164756011416	Na binding site [ion binding]; other site
164756011417	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
164756011418	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
164756011419	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756011420	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
164756011421	Predicted transcriptional regulators [Transcription]; Region: COG1725
164756011422	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756011423	DNA-binding site [nucleotide binding]; DNA binding site
164756011424	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
164756011425	NAD-dependent deacetylase; Provisional; Region: PRK00481
164756011426	NAD+ binding site [chemical binding]; other site
164756011427	substrate binding site [chemical binding]; other site
164756011428	Zn binding site [ion binding]; other site
164756011429	Methyltransferase domain; Region: Methyltransf_23; pfam13489
164756011430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756011431	S-adenosylmethionine binding site [chemical binding]; other site
164756011432	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
164756011433	DoxX; Region: DoxX; pfam07681
164756011434	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
164756011435	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
164756011436	FMN binding site [chemical binding]; other site
164756011437	substrate binding site [chemical binding]; other site
164756011438	putative catalytic residue [active]
164756011439	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
164756011440	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
164756011441	NAD binding site [chemical binding]; other site
164756011442	homodimer interface [polypeptide binding]; other site
164756011443	homotetramer interface [polypeptide binding]; other site
164756011444	active site
164756011445	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756011446	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756011447	enoyl-CoA hydratase; Provisional; Region: PRK06688
164756011448	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756011449	substrate binding site [chemical binding]; other site
164756011450	oxyanion hole (OAH) forming residues; other site
164756011451	trimer interface [polypeptide binding]; other site
164756011452	HicB family; Region: HicB; pfam05534
164756011453	CAAX protease self-immunity; Region: Abi; pfam02517
164756011454	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
164756011455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756011456	NAD(P) binding site [chemical binding]; other site
164756011457	active site
164756011458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756011459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756011460	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
164756011461	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
164756011462	active site
164756011463	catalytic tetrad [active]
164756011464	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
164756011465	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
164756011466	trimer interface [polypeptide binding]; other site
164756011467	putative metal binding site [ion binding]; other site
164756011468	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
164756011469	Fasciclin domain; Region: Fasciclin; pfam02469
164756011470	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756011471	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756011472	active site
164756011473	enoyl-CoA hydratase; Provisional; Region: PRK08252
164756011474	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756011475	substrate binding site [chemical binding]; other site
164756011476	oxyanion hole (OAH) forming residues; other site
164756011477	trimer interface [polypeptide binding]; other site
164756011478	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
164756011479	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756011480	dimer interface [polypeptide binding]; other site
164756011481	active site
164756011482	Transcriptional regulators [Transcription]; Region: FadR; COG2186
164756011483	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756011484	FCD domain; Region: FCD; pfam07729
164756011485	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
164756011486	Predicted membrane protein [Function unknown]; Region: COG2259
164756011487	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756011488	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
164756011489	classical (c) SDRs; Region: SDR_c; cd05233
164756011490	NAD(P) binding site [chemical binding]; other site
164756011491	active site
164756011492	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756011493	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
164756011494	dimer interface [polypeptide binding]; other site
164756011495	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756011496	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756011497	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
164756011498	hypothetical protein; Provisional; Region: PRK06149
164756011499	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
164756011500	active site
164756011501	ATP binding site [chemical binding]; other site
164756011502	substrate binding site [chemical binding]; other site
164756011503	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756011504	inhibitor-cofactor binding pocket; inhibition site
164756011505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756011506	catalytic residue [active]
164756011507	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756011508	cyclase homology domain; Region: CHD; cd07302
164756011509	nucleotidyl binding site; other site
164756011510	metal binding site [ion binding]; metal-binding site
164756011511	dimer interface [polypeptide binding]; other site
164756011512	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756011513	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756011514	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
164756011515	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
164756011516	putative hydrophobic ligand binding site [chemical binding]; other site
164756011517	Domain of unknown function (DU1801); Region: DUF1801; cl17490
164756011518	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756011519	dimerization interface [polypeptide binding]; other site
164756011520	putative DNA binding site [nucleotide binding]; other site
164756011521	putative Zn2+ binding site [ion binding]; other site
164756011522	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
164756011523	active site residue [active]
164756011524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756011525	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756011526	putative substrate translocation pore; other site
164756011527	Methyltransferase domain; Region: Methyltransf_23; pfam13489
164756011528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756011529	S-adenosylmethionine binding site [chemical binding]; other site
164756011530	GTP-binding protein YchF; Reviewed; Region: PRK09601
164756011531	YchF GTPase; Region: YchF; cd01900
164756011532	G1 box; other site
164756011533	GTP/Mg2+ binding site [chemical binding]; other site
164756011534	Switch I region; other site
164756011535	G2 box; other site
164756011536	Switch II region; other site
164756011537	G3 box; other site
164756011538	G4 box; other site
164756011539	G5 box; other site
164756011540	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
164756011541	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
164756011542	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
164756011543	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
164756011544	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
164756011545	generic binding surface II; other site
164756011546	generic binding surface I; other site
164756011547	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
164756011548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756011549	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
164756011550	NAD(P) binding site [chemical binding]; other site
164756011551	active site
164756011552	MgtC family; Region: MgtC; pfam02308
164756011553	magnesium transport protein MgtC; Provisional; Region: PRK15385
164756011554	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
164756011555	Sulfatase; Region: Sulfatase; pfam00884
164756011556	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
164756011557	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
164756011558	Uncharacterized conserved protein [Function unknown]; Region: COG1262
164756011559	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
164756011560	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756011561	classical (c) SDRs; Region: SDR_c; cd05233
164756011562	NAD(P) binding site [chemical binding]; other site
164756011563	active site
164756011564	classical (c) SDRs; Region: SDR_c; cd05233
164756011565	short chain dehydrogenase; Provisional; Region: PRK05650
164756011566	NAD(P) binding site [chemical binding]; other site
164756011567	active site
164756011568	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
164756011569	Domain of unknown function DUF20; Region: UPF0118; pfam01594
164756011570	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
164756011571	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
164756011572	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
164756011573	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
164756011574	putative active site [active]
164756011575	fumarate hydratase; Reviewed; Region: fumC; PRK00485
164756011576	Class II fumarases; Region: Fumarase_classII; cd01362
164756011577	active site
164756011578	tetramer interface [polypeptide binding]; other site
164756011579	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
164756011580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756011581	NAD(P) binding site [chemical binding]; other site
164756011582	active site
164756011583	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
164756011584	dimer interface [polypeptide binding]; other site
164756011585	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
164756011586	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
164756011587	GAF domain; Region: GAF_3; pfam13492
164756011588	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756011589	Histidine kinase; Region: HisKA_3; pfam07730
164756011590	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756011591	ATP binding site [chemical binding]; other site
164756011592	Mg2+ binding site [ion binding]; other site
164756011593	G-X-G motif; other site
164756011594	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756011595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756011596	active site
164756011597	phosphorylation site [posttranslational modification]
164756011598	intermolecular recognition site; other site
164756011599	dimerization interface [polypeptide binding]; other site
164756011600	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756011601	DNA binding residues [nucleotide binding]
164756011602	dimerization interface [polypeptide binding]; other site
164756011603	Universal stress protein family; Region: Usp; pfam00582
164756011604	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
164756011605	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
164756011606	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
164756011607	putative active site [active]
164756011608	PhoH-like protein; Region: PhoH; pfam02562
164756011609	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
164756011610	dinuclear metal binding motif [ion binding]; other site
164756011611	serine hydroxymethyltransferase; Provisional; Region: PRK13580
164756011612	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
164756011613	dimer interface [polypeptide binding]; other site
164756011614	active site
164756011615	glycine-pyridoxal phosphate binding site [chemical binding]; other site
164756011616	folate binding site [chemical binding]; other site
164756011617	pantothenate kinase; Provisional; Region: PRK05439
164756011618	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
164756011619	ATP-binding site [chemical binding]; other site
164756011620	CoA-binding site [chemical binding]; other site
164756011621	Mg2+-binding site [ion binding]; other site
164756011622	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
164756011623	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
164756011624	catalytic residue [active]
164756011625	putative FPP diphosphate  binding site; other site
164756011626	putative FPP binding hydrophobic cleft; other site
164756011627	dimer interface [polypeptide binding]; other site
164756011628	putative IPP diphosphate binding site; other site
164756011629	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
164756011630	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
164756011631	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
164756011632	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
164756011633	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
164756011634	catalytic residues [active]
164756011635	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
164756011636	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
164756011637	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
164756011638	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
164756011639	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
164756011640	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
164756011641	cystathionine gamma-synthase; Provisional; Region: PRK07811
164756011642	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
164756011643	homodimer interface [polypeptide binding]; other site
164756011644	substrate-cofactor binding pocket; other site
164756011645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756011646	catalytic residue [active]
164756011647	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756011648	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756011649	active site
164756011650	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
164756011651	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
164756011652	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
164756011653	dimer interface [polypeptide binding]; other site
164756011654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756011655	catalytic residue [active]
164756011656	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
164756011657	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
164756011658	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
164756011659	active site
164756011660	catalytic triad [active]
164756011661	oxyanion hole [active]
164756011662	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
164756011663	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756011664	dimer interface [polypeptide binding]; other site
164756011665	active site
164756011666	Bax inhibitor 1 like; Region: BaxI_1; cl17691
164756011667	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
164756011668	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756011669	substrate binding site [chemical binding]; other site
164756011670	oxyanion hole (OAH) forming residues; other site
164756011671	trimer interface [polypeptide binding]; other site
164756011672	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
164756011673	enoyl-CoA hydratase; Provisional; Region: PRK05862
164756011674	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756011675	substrate binding site [chemical binding]; other site
164756011676	oxyanion hole (OAH) forming residues; other site
164756011677	trimer interface [polypeptide binding]; other site
164756011678	Predicted membrane protein [Function unknown]; Region: COG4425
164756011679	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
164756011680	Protein of unknown function (DUF3631); Region: DUF3631; pfam12307
164756011681	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
164756011682	active site
164756011683	metal binding site [ion binding]; metal-binding site
164756011684	interdomain interaction site; other site
164756011685	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
164756011686	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
164756011687	catalytic residues [active]
164756011688	catalytic nucleophile [active]
164756011689	Recombinase; Region: Recombinase; pfam07508
164756011690	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
164756011691	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
164756011692	active site residue [active]
164756011693	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
164756011694	hypothetical protein; Provisional; Region: PRK10279
164756011695	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
164756011696	active site
164756011697	nucleophile elbow; other site
164756011698	Patatin-like phospholipase; Region: Patatin; pfam01734
164756011699	nucleophile elbow; other site
164756011700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
164756011701	MOSC domain; Region: MOSC; pfam03473
164756011702	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756011703	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756011704	lipid-transfer protein; Provisional; Region: PRK08256
164756011705	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756011706	active site
164756011707	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
164756011708	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
164756011709	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
164756011710	PAS domain; Region: PAS; smart00091
164756011711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756011712	ATP binding site [chemical binding]; other site
164756011713	Mg2+ binding site [ion binding]; other site
164756011714	G-X-G motif; other site
164756011715	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
164756011716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756011717	active site
164756011718	phosphorylation site [posttranslational modification]
164756011719	intermolecular recognition site; other site
164756011720	dimerization interface [polypeptide binding]; other site
164756011721	Homeodomain-like domain; Region: HTH_23; pfam13384
164756011722	Uncharacterized conserved protein [Function unknown]; Region: COG3391
164756011723	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
164756011724	amidase catalytic site [active]
164756011725	Zn binding residues [ion binding]; other site
164756011726	substrate binding site [chemical binding]; other site
164756011727	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
164756011728	Cupin domain; Region: Cupin_2; pfam07883
164756011729	Putative esterase; Region: Esterase; pfam00756
164756011730	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
164756011731	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
164756011732	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
164756011733	Cation efflux family; Region: Cation_efflux; cl00316
164756011734	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756011735	dimerization interface [polypeptide binding]; other site
164756011736	putative DNA binding site [nucleotide binding]; other site
164756011737	putative Zn2+ binding site [ion binding]; other site
164756011738	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
164756011739	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
164756011740	Coenzyme A binding pocket [chemical binding]; other site
164756011741	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
164756011742	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
164756011743	inhibitor-cofactor binding pocket; inhibition site
164756011744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756011745	catalytic residue [active]
164756011746	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
164756011747	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
164756011748	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
164756011749	E-class dimer interface [polypeptide binding]; other site
164756011750	P-class dimer interface [polypeptide binding]; other site
164756011751	active site
164756011752	Cu2+ binding site [ion binding]; other site
164756011753	Zn2+ binding site [ion binding]; other site
164756011754	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
164756011755	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
164756011756	dimer interface [polypeptide binding]; other site
164756011757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756011758	catalytic residue [active]
164756011759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
164756011760	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
164756011761	active site residue [active]
164756011762	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
164756011763	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
164756011764	Cl- selectivity filter; other site
164756011765	Cl- binding residues [ion binding]; other site
164756011766	pore gating glutamate residue; other site
164756011767	dimer interface [polypeptide binding]; other site
164756011768	H+/Cl- coupling transport residue; other site
164756011769	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756011770	Cytochrome P450; Region: p450; cl12078
164756011771	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
164756011772	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756011773	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
164756011774	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756011775	Domain of unknown function (DUF385); Region: DUF385; cl04387
164756011776	hypothetical protein; Provisional; Region: PRK08317
164756011777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756011778	S-adenosylmethionine binding site [chemical binding]; other site
164756011779	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
164756011780	aldose dehydrogenase; Validated; Region: PRK06398
164756011781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756011782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756011783	active site
164756011784	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
164756011785	active site
164756011786	diiron metal binding site [ion binding]; other site
164756011787	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756011788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756011789	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
164756011790	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
164756011791	substrate binding pocket [chemical binding]; other site
164756011792	catalytic triad [active]
164756011793	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756011794	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756011795	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
164756011796	salt bridge; other site
164756011797	non-specific DNA binding site [nucleotide binding]; other site
164756011798	sequence-specific DNA binding site [nucleotide binding]; other site
164756011799	Domain of unknown function (DUF385); Region: DUF385; cl04387
164756011800	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756011801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756011802	putative substrate translocation pore; other site
164756011803	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756011804	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756011805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756011806	D-galactonate transporter; Region: 2A0114; TIGR00893
164756011807	putative substrate translocation pore; other site
164756011808	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
164756011809	homotrimer interaction site [polypeptide binding]; other site
164756011810	putative active site [active]
164756011811	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
164756011812	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
164756011813	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
164756011814	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756011815	Soluble P-type ATPase [General function prediction only]; Region: COG4087
164756011816	K+-transporting ATPase, c chain; Region: KdpC; cl00944
164756011817	K+-transporting ATPase, c chain; Region: KdpC; cl00944
164756011818	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
164756011819	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
164756011820	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
164756011821	Ligand Binding Site [chemical binding]; other site
164756011822	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756011823	dimer interface [polypeptide binding]; other site
164756011824	phosphorylation site [posttranslational modification]
164756011825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756011826	ATP binding site [chemical binding]; other site
164756011827	Mg2+ binding site [ion binding]; other site
164756011828	G-X-G motif; other site
164756011829	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
164756011830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756011831	active site
164756011832	phosphorylation site [posttranslational modification]
164756011833	intermolecular recognition site; other site
164756011834	dimerization interface [polypeptide binding]; other site
164756011835	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756011836	DNA binding site [nucleotide binding]
164756011837	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
164756011838	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756011839	acyl-activating enzyme (AAE) consensus motif; other site
164756011840	AMP binding site [chemical binding]; other site
164756011841	active site
164756011842	CoA binding site [chemical binding]; other site
164756011843	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756011844	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756011845	active site
164756011846	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
164756011847	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
164756011848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756011849	Radical SAM superfamily; Region: Radical_SAM; pfam04055
164756011850	FeS/SAM binding site; other site
164756011851	exopolyphosphatase; Region: exo_poly_only; TIGR03706
164756011852	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
164756011853	Uncharacterized conserved protein [Function unknown]; Region: COG1507
164756011854	Septum formation initiator; Region: DivIC; pfam04977
164756011855	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
164756011856	enolase; Provisional; Region: eno; PRK00077
164756011857	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
164756011858	dimer interface [polypeptide binding]; other site
164756011859	metal binding site [ion binding]; metal-binding site
164756011860	substrate binding pocket [chemical binding]; other site
164756011861	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
164756011862	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
164756011863	N-acetyl-D-glucosamine binding site [chemical binding]; other site
164756011864	Imelysin; Region: Peptidase_M75; pfam09375
164756011865	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
164756011866	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
164756011867	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
164756011868	homodimer interface [polypeptide binding]; other site
164756011869	metal binding site [ion binding]; metal-binding site
164756011870	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
164756011871	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
164756011872	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756011873	ATP binding site [chemical binding]; other site
164756011874	putative Mg++ binding site [ion binding]; other site
164756011875	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756011876	nucleotide binding region [chemical binding]; other site
164756011877	ATP-binding site [chemical binding]; other site
164756011878	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
164756011879	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756011880	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756011881	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
164756011882	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
164756011883	Substrate binding site; other site
164756011884	Mg++ binding site; other site
164756011885	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
164756011886	active site
164756011887	substrate binding site [chemical binding]; other site
164756011888	CoA binding site [chemical binding]; other site
164756011889	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
164756011890	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
164756011891	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756011892	active site
164756011893	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
164756011894	ArsC family; Region: ArsC; pfam03960
164756011895	catalytic residues [active]
164756011896	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
164756011897	short chain dehydrogenase; Provisional; Region: PRK06197
164756011898	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
164756011899	putative NAD(P) binding site [chemical binding]; other site
164756011900	active site
164756011901	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
164756011902	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
164756011903	5S rRNA interface [nucleotide binding]; other site
164756011904	CTC domain interface [polypeptide binding]; other site
164756011905	L16 interface [polypeptide binding]; other site
164756011906	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
164756011907	putative active site [active]
164756011908	catalytic residue [active]
164756011909	Protein of unknown function, DUF488; Region: DUF488; pfam04343
164756011910	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
164756011911	4Fe-4S binding domain; Region: Fer4; pfam00037
164756011912	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
164756011913	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756011914	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756011915	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756011916	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
164756011917	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
164756011918	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
164756011919	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756011920	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
164756011921	Walker A/P-loop; other site
164756011922	ATP binding site [chemical binding]; other site
164756011923	Q-loop/lid; other site
164756011924	ABC transporter signature motif; other site
164756011925	Walker B; other site
164756011926	D-loop; other site
164756011927	H-loop/switch region; other site
164756011928	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
164756011929	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
164756011930	acyl-activating enzyme (AAE) consensus motif; other site
164756011931	active site
164756011932	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
164756011933	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
164756011934	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
164756011935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756011936	S-adenosylmethionine binding site [chemical binding]; other site
164756011937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
164756011938	Domain of unknown function (DUF348); Region: DUF348; pfam03990
164756011939	Domain of unknown function (DUF348); Region: DUF348; pfam03990
164756011940	Domain of unknown function (DUF348); Region: DUF348; pfam03990
164756011941	G5 domain; Region: G5; pfam07501
164756011942	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
164756011943	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
164756011944	active site
164756011945	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
164756011946	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
164756011947	active site
164756011948	HIGH motif; other site
164756011949	KMSKS motif; other site
164756011950	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
164756011951	tRNA binding surface [nucleotide binding]; other site
164756011952	anticodon binding site; other site
164756011953	glutamate dehydrogenase; Provisional; Region: PRK09414
164756011954	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
164756011955	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
164756011956	NAD(P) binding site [chemical binding]; other site
164756011957	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
164756011958	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756011959	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
164756011960	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756011961	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756011962	DNA binding residues [nucleotide binding]
164756011963	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756011964	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
164756011965	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
164756011966	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756011967	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756011968	DNA binding residues [nucleotide binding]
164756011969	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
164756011970	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
164756011971	chorismate binding enzyme; Region: Chorismate_bind; cl10555
164756011972	Predicted methyltransferases [General function prediction only]; Region: COG0313
164756011973	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
164756011974	putative SAM binding site [chemical binding]; other site
164756011975	putative homodimer interface [polypeptide binding]; other site
164756011976	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
164756011977	arginine deiminase; Provisional; Region: PRK01388
164756011978	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
164756011979	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
164756011980	DNA binding residues [nucleotide binding]
164756011981	dimer interface [polypeptide binding]; other site
164756011982	[2Fe-2S] cluster binding site [ion binding]; other site
164756011983	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
164756011984	PE-PPE domain; Region: PE-PPE; pfam08237
164756011985	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
164756011986	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
164756011987	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
164756011988	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
164756011989	shikimate binding site; other site
164756011990	NAD(P) binding site [chemical binding]; other site
164756011991	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
164756011992	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
164756011993	ligand binding site [chemical binding]; other site
164756011994	flexible hinge region; other site
164756011995	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
164756011996	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
164756011997	Uncharacterized conserved protein [Function unknown]; Region: COG5361
164756011998	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
164756011999	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
164756012000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
164756012001	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
164756012002	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
164756012003	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
164756012004	dimer interface [polypeptide binding]; other site
164756012005	putative functional site; other site
164756012006	putative MPT binding site; other site
164756012007	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
164756012008	active site
164756012009	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
164756012010	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
164756012011	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
164756012012	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
164756012013	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
164756012014	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
164756012015	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
164756012016	Homeodomain-like domain; Region: HTH_23; pfam13384
164756012017	Helix-turn-helix domain; Region: HTH_38; pfam13936
164756012018	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
164756012019	Integrase core domain; Region: rve; pfam00665
164756012020	MspA; Region: MspA; pfam09203
164756012021	MspA; Region: MspA; pfam09203
164756012022	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
164756012023	MPT binding site; other site
164756012024	trimer interface [polypeptide binding]; other site
164756012025	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
164756012026	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
164756012027	protein binding site [polypeptide binding]; other site
164756012028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756012029	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756012030	dimerization interface [polypeptide binding]; other site
164756012031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756012032	dimer interface [polypeptide binding]; other site
164756012033	phosphorylation site [posttranslational modification]
164756012034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756012035	ATP binding site [chemical binding]; other site
164756012036	Mg2+ binding site [ion binding]; other site
164756012037	G-X-G motif; other site
164756012038	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756012039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756012040	active site
164756012041	phosphorylation site [posttranslational modification]
164756012042	intermolecular recognition site; other site
164756012043	dimerization interface [polypeptide binding]; other site
164756012044	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756012045	DNA binding site [nucleotide binding]
164756012046	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
164756012047	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
164756012048	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756012049	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756012050	active site
164756012051	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
164756012052	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
164756012053	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
164756012054	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
164756012055	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
164756012056	ATP-grasp domain; Region: ATP-grasp_4; cl17255
164756012057	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
164756012058	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
164756012059	carboxyltransferase (CT) interaction site; other site
164756012060	biotinylation site [posttranslational modification]; other site
164756012061	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756012062	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756012063	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756012064	active site
164756012065	enoyl-CoA hydratase; Provisional; Region: PRK07827
164756012066	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756012067	substrate binding site [chemical binding]; other site
164756012068	oxyanion hole (OAH) forming residues; other site
164756012069	trimer interface [polypeptide binding]; other site
164756012070	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
164756012071	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
164756012072	PE-PPE domain; Region: PE-PPE; pfam08237
164756012073	PE-PPE domain; Region: PE-PPE; pfam08237
164756012074	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
164756012075	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
164756012076	metal ion-dependent adhesion site (MIDAS); other site
164756012077	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
164756012078	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
164756012079	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
164756012080	Sulfate transporter family; Region: Sulfate_transp; pfam00916
164756012081	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
164756012082	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756012083	dimerization interface [polypeptide binding]; other site
164756012084	putative DNA binding site [nucleotide binding]; other site
164756012085	putative Zn2+ binding site [ion binding]; other site
164756012086	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756012087	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756012088	active site
164756012089	ATP binding site [chemical binding]; other site
164756012090	substrate binding site [chemical binding]; other site
164756012091	activation loop (A-loop); other site
164756012092	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
164756012093	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756012094	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756012095	metal binding site [ion binding]; metal-binding site
164756012096	active site
164756012097	I-site; other site
164756012098	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
164756012099	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
164756012100	purine monophosphate binding site [chemical binding]; other site
164756012101	dimer interface [polypeptide binding]; other site
164756012102	putative catalytic residues [active]
164756012103	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
164756012104	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
164756012105	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
164756012106	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
164756012107	active site
164756012108	cosubstrate binding site; other site
164756012109	substrate binding site [chemical binding]; other site
164756012110	catalytic site [active]
164756012111	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
164756012112	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
164756012113	active site
164756012114	dimer interface [polypeptide binding]; other site
164756012115	non-prolyl cis peptide bond; other site
164756012116	insertion regions; other site
164756012117	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756012118	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756012119	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
164756012120	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
164756012121	active site
164756012122	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
164756012123	CoA binding domain; Region: CoA_binding; smart00881
164756012124	CoA-ligase; Region: Ligase_CoA; pfam00549
164756012125	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
164756012126	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
164756012127	CoA-ligase; Region: Ligase_CoA; pfam00549
164756012128	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
164756012129	Peptidase family M23; Region: Peptidase_M23; pfam01551
164756012130	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
164756012131	Part of AAA domain; Region: AAA_19; pfam13245
164756012132	Family description; Region: UvrD_C_2; pfam13538
164756012133	hypothetical protein; Provisional; Region: PRK07857
164756012134	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756012135	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
164756012136	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
164756012137	active site
164756012138	catalytic triad [active]
164756012139	oxyanion hole [active]
164756012140	succinic semialdehyde dehydrogenase; Region: PLN02278
164756012141	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
164756012142	tetramerization interface [polypeptide binding]; other site
164756012143	NAD(P) binding site [chemical binding]; other site
164756012144	catalytic residues [active]
164756012145	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
164756012146	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
164756012147	active site
164756012148	dimer interface [polypeptide binding]; other site
164756012149	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
164756012150	dimer interface [polypeptide binding]; other site
164756012151	active site
164756012152	short chain dehydrogenase; Provisional; Region: PRK08251
164756012153	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
164756012154	putative NAD(P) binding site [chemical binding]; other site
164756012155	active site
164756012156	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
164756012157	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
164756012158	putative DNA binding site [nucleotide binding]; other site
164756012159	catalytic residue [active]
164756012160	putative H2TH interface [polypeptide binding]; other site
164756012161	putative catalytic residues [active]
164756012162	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
164756012163	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
164756012164	Predicted membrane protein [Function unknown]; Region: COG1950
164756012165	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
164756012166	active site
164756012167	SAM binding site [chemical binding]; other site
164756012168	homodimer interface [polypeptide binding]; other site
164756012169	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
164756012170	thiamine pyrophosphate protein; Provisional; Region: PRK08273
164756012171	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
164756012172	PYR/PP interface [polypeptide binding]; other site
164756012173	dimer interface [polypeptide binding]; other site
164756012174	tetramer interface [polypeptide binding]; other site
164756012175	TPP binding site [chemical binding]; other site
164756012176	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
164756012177	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
164756012178	TPP-binding site [chemical binding]; other site
164756012179	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756012180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756012181	putative substrate translocation pore; other site
164756012182	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
164756012183	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756012184	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756012185	Helix-turn-helix domain; Region: HTH_18; pfam12833
164756012186	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756012187	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
164756012188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756012189	NAD(P) binding site [chemical binding]; other site
164756012190	active site
164756012191	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
164756012192	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
164756012193	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
164756012194	phosphopeptide binding site; other site
164756012195	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756012196	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
164756012197	DNA binding residues [nucleotide binding]
164756012198	dimerization interface [polypeptide binding]; other site
164756012199	Protein kinase domain; Region: Pkinase; pfam00069
164756012200	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756012201	active site
164756012202	ATP binding site [chemical binding]; other site
164756012203	substrate binding site [chemical binding]; other site
164756012204	activation loop (A-loop); other site
164756012205	Kelch motif; Region: Kelch_6; pfam13964
164756012206	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
164756012207	Kelch domain; Region: Kelch; smart00612
164756012208	Kelch motif; Region: Kelch_1; pfam01344
164756012209	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
164756012210	Kelch motif; Region: Kelch_1; pfam01344
164756012211	Kelch domain; Region: Kelch; smart00612
164756012212	Kelch motif; Region: Kelch_1; pfam01344
164756012213	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
164756012214	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
164756012215	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
164756012216	active site
164756012217	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
164756012218	RNA/DNA hybrid binding site [nucleotide binding]; other site
164756012219	active site
164756012220	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756012221	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756012222	active site
164756012223	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
164756012224	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
164756012225	nucleotide binding site [chemical binding]; other site
164756012226	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
164756012227	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
164756012228	active site
164756012229	DNA binding site [nucleotide binding]
164756012230	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
164756012231	DNA binding site [nucleotide binding]
164756012232	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
164756012233	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
164756012234	Walker A/P-loop; other site
164756012235	ATP binding site [chemical binding]; other site
164756012236	Q-loop/lid; other site
164756012237	ABC transporter signature motif; other site
164756012238	Walker B; other site
164756012239	D-loop; other site
164756012240	H-loop/switch region; other site
164756012241	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
164756012242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756012243	dimer interface [polypeptide binding]; other site
164756012244	conserved gate region; other site
164756012245	putative PBP binding loops; other site
164756012246	ABC-ATPase subunit interface; other site
164756012247	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
164756012248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756012249	dimer interface [polypeptide binding]; other site
164756012250	putative PBP binding loops; other site
164756012251	ABC-ATPase subunit interface; other site
164756012252	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
164756012253	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
164756012254	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
164756012255	MarR family; Region: MarR_2; pfam12802
164756012256	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
164756012257	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
164756012258	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
164756012259	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
164756012260	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
164756012261	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
164756012262	putative substrate binding site [chemical binding]; other site
164756012263	putative ATP binding site [chemical binding]; other site
164756012264	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
164756012265	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
164756012266	putative DNA binding site [nucleotide binding]; other site
164756012267	putative homodimer interface [polypeptide binding]; other site
164756012268	short chain dehydrogenase; Provisional; Region: PRK07814
164756012269	classical (c) SDRs; Region: SDR_c; cd05233
164756012270	NAD(P) binding site [chemical binding]; other site
164756012271	active site
164756012272	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756012273	manganese transport protein MntH; Reviewed; Region: PRK00701
164756012274	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
164756012275	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
164756012276	putative active site pocket [active]
164756012277	dimerization interface [polypeptide binding]; other site
164756012278	putative catalytic residue [active]
164756012279	Protein of unknown function (DUF867); Region: DUF867; pfam05908
164756012280	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
164756012281	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
164756012282	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
164756012283	active site
164756012284	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
164756012285	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
164756012286	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756012287	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756012288	DNA binding residues [nucleotide binding]
164756012289	putative anti-sigmaE protein; Provisional; Region: PRK13920
164756012290	Anti-sigma-K factor rskA; Region: RskA; pfam10099
164756012291	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
164756012292	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
164756012293	Subunit I/III interface [polypeptide binding]; other site
164756012294	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
164756012295	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
164756012296	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
164756012297	putative dimer interface [polypeptide binding]; other site
164756012298	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
164756012299	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
164756012300	Transcriptional regulators [Transcription]; Region: FadR; COG2186
164756012301	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756012302	DNA-binding site [nucleotide binding]; DNA binding site
164756012303	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
164756012304	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
164756012305	Cysteine-rich domain; Region: CCG; pfam02754
164756012306	Cysteine-rich domain; Region: CCG; pfam02754
164756012307	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
164756012308	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
164756012309	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
164756012310	Transcriptional regulators [Transcription]; Region: PurR; COG1609
164756012311	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
164756012312	DNA binding site [nucleotide binding]
164756012313	domain linker motif; other site
164756012314	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
164756012315	ligand binding site [chemical binding]; other site
164756012316	dimerization interface [polypeptide binding]; other site
164756012317	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
164756012318	N- and C-terminal domain interface [polypeptide binding]; other site
164756012319	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
164756012320	active site
164756012321	putative catalytic site [active]
164756012322	metal binding site [ion binding]; metal-binding site
164756012323	ATP binding site [chemical binding]; other site
164756012324	carbohydrate binding site [chemical binding]; other site
164756012325	short chain dehydrogenase; Validated; Region: PRK08324
164756012326	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
164756012327	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
164756012328	putative NAD(P) binding site [chemical binding]; other site
164756012329	active site
164756012330	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
164756012331	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
164756012332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756012333	putative substrate translocation pore; other site
164756012334	Domain of unknown function (DUF718); Region: DUF718; pfam05336
164756012335	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
164756012336	active site
164756012337	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
164756012338	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756012339	NAD binding site [chemical binding]; other site
164756012340	catalytic residues [active]
164756012341	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
164756012342	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
164756012343	PYR/PP interface [polypeptide binding]; other site
164756012344	dimer interface [polypeptide binding]; other site
164756012345	TPP binding site [chemical binding]; other site
164756012346	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
164756012347	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
164756012348	TPP-binding site; other site
164756012349	dimer interface [polypeptide binding]; other site
164756012350	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756012351	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756012352	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756012353	active site
164756012354	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756012355	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756012356	active site
164756012357	enoyl-CoA hydratase; Provisional; Region: PRK06688
164756012358	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756012359	substrate binding site [chemical binding]; other site
164756012360	oxyanion hole (OAH) forming residues; other site
164756012361	trimer interface [polypeptide binding]; other site
164756012362	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
164756012363	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
164756012364	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
164756012365	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756012366	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756012367	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756012368	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756012369	active site
164756012370	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756012371	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756012372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756012373	NAD(P) binding site [chemical binding]; other site
164756012374	active site
164756012375	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756012376	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756012377	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756012378	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
164756012379	[2Fe-2S] cluster binding site [ion binding]; other site
164756012380	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
164756012381	hydrophobic ligand binding site; other site
164756012382	classical (c) SDRs; Region: SDR_c; cd05233
164756012383	NAD(P) binding site [chemical binding]; other site
164756012384	active site
164756012385	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
164756012386	PQQ-like domain; Region: PQQ_2; pfam13360
164756012387	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
164756012388	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756012389	DNA-binding site [nucleotide binding]; DNA binding site
164756012390	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
164756012391	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
164756012392	AMP-binding enzyme; Region: AMP-binding; pfam00501
164756012393	acyl-activating enzyme (AAE) consensus motif; other site
164756012394	putative AMP binding site [chemical binding]; other site
164756012395	putative active site [active]
164756012396	putative CoA binding site [chemical binding]; other site
164756012397	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
164756012398	classical (c) SDRs; Region: SDR_c; cd05233
164756012399	NAD(P) binding site [chemical binding]; other site
164756012400	active site
164756012401	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
164756012402	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756012403	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756012404	acyl-activating enzyme (AAE) consensus motif; other site
164756012405	acyl-activating enzyme (AAE) consensus motif; other site
164756012406	putative AMP binding site [chemical binding]; other site
164756012407	putative active site [active]
164756012408	putative CoA binding site [chemical binding]; other site
164756012409	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756012410	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756012411	short chain dehydrogenase; Provisional; Region: PRK07814
164756012412	classical (c) SDRs; Region: SDR_c; cd05233
164756012413	NAD(P) binding site [chemical binding]; other site
164756012414	active site
164756012415	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756012416	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
164756012417	metal ion-dependent adhesion site (MIDAS); other site
164756012418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756012419	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
164756012420	Walker A motif; other site
164756012421	ATP binding site [chemical binding]; other site
164756012422	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
164756012423	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756012424	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756012425	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756012426	Cytochrome P450; Region: p450; cl12078
164756012427	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
164756012428	NADH(P)-binding; Region: NAD_binding_10; pfam13460
164756012429	NAD(P) binding site [chemical binding]; other site
164756012430	putative active site [active]
164756012431	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756012432	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
164756012433	catalytic site [active]
164756012434	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756012435	hydrophobic ligand binding site; other site
164756012436	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
164756012437	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
164756012438	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756012439	Soluble P-type ATPase [General function prediction only]; Region: COG4087
164756012440	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756012441	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756012442	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
164756012443	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
164756012444	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
164756012445	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
164756012446	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756012447	substrate binding site [chemical binding]; other site
164756012448	oxyanion hole (OAH) forming residues; other site
164756012449	trimer interface [polypeptide binding]; other site
164756012450	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
164756012451	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
164756012452	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
164756012453	AMP-binding domain protein; Validated; Region: PRK08315
164756012454	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756012455	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
164756012456	acyl-activating enzyme (AAE) consensus motif; other site
164756012457	acyl-activating enzyme (AAE) consensus motif; other site
164756012458	putative AMP binding site [chemical binding]; other site
164756012459	putative active site [active]
164756012460	putative CoA binding site [chemical binding]; other site
164756012461	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
164756012462	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756012463	acyl-activating enzyme (AAE) consensus motif; other site
164756012464	AMP binding site [chemical binding]; other site
164756012465	active site
164756012466	CoA binding site [chemical binding]; other site
164756012467	GAF domain; Region: GAF; pfam01590
164756012468	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756012469	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756012470	DNA binding residues [nucleotide binding]
164756012471	dimerization interface [polypeptide binding]; other site
164756012472	Epoxide hydrolase N terminus; Region: EHN; pfam06441
164756012473	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756012474	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756012475	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756012476	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756012477	metal binding site [ion binding]; metal-binding site
164756012478	active site
164756012479	I-site; other site
164756012480	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
164756012481	putative active site [active]
164756012482	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
164756012483	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
164756012484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756012485	Walker A/P-loop; other site
164756012486	ATP binding site [chemical binding]; other site
164756012487	Q-loop/lid; other site
164756012488	ABC transporter signature motif; other site
164756012489	Walker B; other site
164756012490	D-loop; other site
164756012491	H-loop/switch region; other site
164756012492	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
164756012493	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
164756012494	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756012495	Walker A/P-loop; other site
164756012496	ATP binding site [chemical binding]; other site
164756012497	Q-loop/lid; other site
164756012498	ABC transporter signature motif; other site
164756012499	Walker B; other site
164756012500	D-loop; other site
164756012501	H-loop/switch region; other site
164756012502	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
164756012503	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
164756012504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756012505	Walker A/P-loop; other site
164756012506	ATP binding site [chemical binding]; other site
164756012507	Q-loop/lid; other site
164756012508	ABC transporter signature motif; other site
164756012509	Walker B; other site
164756012510	D-loop; other site
164756012511	H-loop/switch region; other site
164756012512	Ion channel; Region: Ion_trans_2; pfam07885
164756012513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756012514	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756012515	active site
164756012516	phosphorylation site [posttranslational modification]
164756012517	intermolecular recognition site; other site
164756012518	dimerization interface [polypeptide binding]; other site
164756012519	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756012520	DNA binding site [nucleotide binding]
164756012521	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756012522	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756012523	dimerization interface [polypeptide binding]; other site
164756012524	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756012525	dimer interface [polypeptide binding]; other site
164756012526	phosphorylation site [posttranslational modification]
164756012527	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756012528	ATP binding site [chemical binding]; other site
164756012529	Mg2+ binding site [ion binding]; other site
164756012530	G-X-G motif; other site
164756012531	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
164756012532	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
164756012533	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756012534	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
164756012535	MarR family; Region: MarR_2; cl17246
164756012536	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756012537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756012538	putative substrate translocation pore; other site
164756012539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756012540	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
164756012541	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
164756012542	dimer interface [polypeptide binding]; other site
164756012543	active site
164756012544	citrylCoA binding site [chemical binding]; other site
164756012545	NADH binding [chemical binding]; other site
164756012546	cationic pore residues; other site
164756012547	oxalacetate/citrate binding site [chemical binding]; other site
164756012548	coenzyme A binding site [chemical binding]; other site
164756012549	catalytic triad [active]
164756012550	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
164756012551	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756012552	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
164756012553	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
164756012554	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
164756012555	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
164756012556	dimer interface [polypeptide binding]; other site
164756012557	Citrate synthase; Region: Citrate_synt; pfam00285
164756012558	active site
164756012559	citrylCoA binding site [chemical binding]; other site
164756012560	oxalacetate/citrate binding site [chemical binding]; other site
164756012561	coenzyme A binding site [chemical binding]; other site
164756012562	catalytic triad [active]
164756012563	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
164756012564	putative dimer interface [polypeptide binding]; other site
164756012565	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756012566	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
164756012567	4Fe-4S binding domain; Region: Fer4; pfam00037
164756012568	ferredoxin-NADP+ reductase; Region: PLN02852
164756012569	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756012570	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
164756012571	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
164756012572	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756012573	catalytic residue [active]
164756012574	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
164756012575	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
164756012576	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
164756012577	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
164756012578	MarR family; Region: MarR_2; cl17246
164756012579	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
164756012580	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756012581	hydrophobic ligand binding site; other site
164756012582	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
164756012583	H+ Antiporter protein; Region: 2A0121; TIGR00900
164756012584	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
164756012585	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
164756012586	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
164756012587	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
164756012588	putative dimer interface [polypeptide binding]; other site
164756012589	N-terminal domain interface [polypeptide binding]; other site
164756012590	putative substrate binding pocket (H-site) [chemical binding]; other site
164756012591	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
164756012592	DNA-binding site [nucleotide binding]; DNA binding site
164756012593	RNA-binding motif; other site
164756012594	hypothetical protein; Provisional; Region: PRK11770
164756012595	Domain of unknown function (DUF307); Region: DUF307; pfam03733
164756012596	Domain of unknown function (DUF307); Region: DUF307; pfam03733
164756012597	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
164756012598	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
164756012599	FeS/SAM binding site; other site
164756012600	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
164756012601	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
164756012602	MoaE interaction surface [polypeptide binding]; other site
164756012603	thiocarboxylated glycine; other site
164756012604	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
164756012605	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
164756012606	MoaE homodimer interface [polypeptide binding]; other site
164756012607	MoaD interaction [polypeptide binding]; other site
164756012608	active site residues [active]
164756012609	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
164756012610	MPT binding site; other site
164756012611	trimer interface [polypeptide binding]; other site
164756012612	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
164756012613	trimer interface [polypeptide binding]; other site
164756012614	dimer interface [polypeptide binding]; other site
164756012615	putative active site [active]
164756012616	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
164756012617	WYL domain; Region: WYL; pfam13280
164756012618	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
164756012619	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
164756012620	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
164756012621	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756012622	ATP binding site [chemical binding]; other site
164756012623	putative Mg++ binding site [ion binding]; other site
164756012624	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756012625	nucleotide binding region [chemical binding]; other site
164756012626	ATP-binding site [chemical binding]; other site
164756012627	ethanolamine permease; Region: 2A0305; TIGR00908
164756012628	Cupin domain; Region: Cupin_2; cl17218
164756012629	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756012630	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
164756012631	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
164756012632	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
164756012633	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756012634	AMP binding site [chemical binding]; other site
164756012635	active site
164756012636	acyl-activating enzyme (AAE) consensus motif; other site
164756012637	CoA binding site [chemical binding]; other site
164756012638	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
164756012639	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756012640	substrate binding site [chemical binding]; other site
164756012641	oxyanion hole (OAH) forming residues; other site
164756012642	trimer interface [polypeptide binding]; other site
164756012643	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
164756012644	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
164756012645	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
164756012646	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756012647	dimer interface [polypeptide binding]; other site
164756012648	active site
164756012649	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
164756012650	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
164756012651	FMN binding site [chemical binding]; other site
164756012652	active site
164756012653	substrate binding site [chemical binding]; other site
164756012654	catalytic residue [active]
164756012655	short chain dehydrogenase; Validated; Region: PRK08264
164756012656	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756012657	NAD(P) binding site [chemical binding]; other site
164756012658	active site
164756012659	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756012660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756012661	aminotransferase; Validated; Region: PRK07777
164756012662	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756012663	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756012664	homodimer interface [polypeptide binding]; other site
164756012665	catalytic residue [active]
164756012666	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
164756012667	putative hydrophobic ligand binding site [chemical binding]; other site
164756012668	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
164756012669	putative hydrophobic ligand binding site [chemical binding]; other site
164756012670	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
164756012671	putative hydrophobic ligand binding site [chemical binding]; other site
164756012672	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
164756012673	putative hydrophobic ligand binding site [chemical binding]; other site
164756012674	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
164756012675	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
164756012676	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756012677	NAD(P) binding site [chemical binding]; other site
164756012678	active site
164756012679	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756012680	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756012681	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
164756012682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756012683	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756012684	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756012685	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756012686	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756012687	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
164756012688	apolar tunnel; other site
164756012689	heme binding site [chemical binding]; other site
164756012690	dimerization interface [polypeptide binding]; other site
164756012691	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
164756012692	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756012693	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756012694	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
164756012695	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
164756012696	homodimer interface [polypeptide binding]; other site
164756012697	putative substrate binding pocket [chemical binding]; other site
164756012698	diiron center [ion binding]; other site
164756012699	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
164756012700	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
164756012701	FMN binding site [chemical binding]; other site
164756012702	active site
164756012703	catalytic residues [active]
164756012704	substrate binding site [chemical binding]; other site
164756012705	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
164756012706	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
164756012707	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
164756012708	PhoU domain; Region: PhoU; pfam01895
164756012709	PhoU domain; Region: PhoU; pfam01895
164756012710	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756012711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756012712	active site
164756012713	phosphorylation site [posttranslational modification]
164756012714	intermolecular recognition site; other site
164756012715	dimerization interface [polypeptide binding]; other site
164756012716	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756012717	DNA binding site [nucleotide binding]
164756012718	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
164756012719	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
164756012720	Walker A/P-loop; other site
164756012721	ATP binding site [chemical binding]; other site
164756012722	Q-loop/lid; other site
164756012723	ABC transporter signature motif; other site
164756012724	Walker B; other site
164756012725	D-loop; other site
164756012726	H-loop/switch region; other site
164756012727	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
164756012728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756012729	dimer interface [polypeptide binding]; other site
164756012730	conserved gate region; other site
164756012731	putative PBP binding loops; other site
164756012732	ABC-ATPase subunit interface; other site
164756012733	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
164756012734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756012735	dimer interface [polypeptide binding]; other site
164756012736	conserved gate region; other site
164756012737	ABC-ATPase subunit interface; other site
164756012738	PBP superfamily domain; Region: PBP_like_2; cl17296
164756012739	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756012740	putative DNA binding site [nucleotide binding]; other site
164756012741	putative Zn2+ binding site [ion binding]; other site
164756012742	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
164756012743	Low molecular weight phosphatase family; Region: LMWPc; cl00105
164756012744	active site
164756012745	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
164756012746	Low molecular weight phosphatase family; Region: LMWPc; cd00115
164756012747	active site
164756012748	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
164756012749	arsenical-resistance protein; Region: acr3; TIGR00832
164756012750	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756012751	dimerization interface [polypeptide binding]; other site
164756012752	putative DNA binding site [nucleotide binding]; other site
164756012753	putative Zn2+ binding site [ion binding]; other site
164756012754	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
164756012755	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
164756012756	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756012757	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756012758	DNA binding site [nucleotide binding]
164756012759	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
164756012760	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
164756012761	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
164756012762	catalytic residues [active]
164756012763	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
164756012764	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
164756012765	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
164756012766	active site residue [active]
164756012767	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
164756012768	active site residue [active]
164756012769	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
164756012770	Protein of unknown function (DUF732); Region: DUF732; pfam05305
164756012771	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
164756012772	heme-binding site [chemical binding]; other site
164756012773	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
164756012774	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
164756012775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756012776	catalytic residue [active]
164756012777	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
164756012778	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
164756012779	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
164756012780	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
164756012781	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
164756012782	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
164756012783	dimerization interface [polypeptide binding]; other site
164756012784	putative ATP binding site [chemical binding]; other site
164756012785	Cupin domain; Region: Cupin_2; cl17218
164756012786	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
164756012787	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
164756012788	putative NAD(P) binding site [chemical binding]; other site
164756012789	putative active site [active]
164756012790	amidophosphoribosyltransferase; Provisional; Region: PRK07847
164756012791	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
164756012792	active site
164756012793	tetramer interface [polypeptide binding]; other site
164756012794	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756012795	active site
164756012796	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756012797	mce related protein; Region: MCE; pfam02470
164756012798	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756012799	CAAX protease self-immunity; Region: Abi; pfam02517
164756012800	Predicted membrane protein [Function unknown]; Region: COG4425
164756012801	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
164756012802	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
164756012803	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
164756012804	dimerization interface [polypeptide binding]; other site
164756012805	ATP binding site [chemical binding]; other site
164756012806	Uncharacterized conserved protein [Function unknown]; Region: COG3375
164756012807	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
164756012808	dimerization interface [polypeptide binding]; other site
164756012809	ATP binding site [chemical binding]; other site
164756012810	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
164756012811	PE-PPE domain; Region: PE-PPE; pfam08237
164756012812	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
164756012813	active site
164756012814	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756012815	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
164756012816	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
164756012817	active site
164756012818	metal binding site [ion binding]; metal-binding site
164756012819	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
164756012820	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
164756012821	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
164756012822	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
164756012823	putative active site [active]
164756012824	catalytic triad [active]
164756012825	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
164756012826	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
164756012827	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
164756012828	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
164756012829	Predicted deacetylase [General function prediction only]; Region: COG3233
164756012830	putative active site [active]
164756012831	putative Zn binding site [ion binding]; other site
164756012832	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
164756012833	catalytic residues [active]
164756012834	dimer interface [polypeptide binding]; other site
164756012835	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756012836	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756012837	WHG domain; Region: WHG; pfam13305
164756012838	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
164756012839	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
164756012840	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
164756012841	ATP binding site [chemical binding]; other site
164756012842	active site
164756012843	substrate binding site [chemical binding]; other site
164756012844	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
164756012845	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
164756012846	DXD motif; other site
164756012847	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756012848	NAD(P) binding site [chemical binding]; other site
164756012849	active site
164756012850	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756012851	Cytochrome P450; Region: p450; cl12078
164756012852	adenylosuccinate lyase; Region: purB; TIGR00928
164756012853	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
164756012854	tetramer interface [polypeptide binding]; other site
164756012855	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
164756012856	amino acid transporter; Region: 2A0306; TIGR00909
164756012857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
164756012858	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
164756012859	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
164756012860	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
164756012861	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
164756012862	Cytochrome P450; Region: p450; cl12078
164756012863	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756012864	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756012865	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
164756012866	DNA-binding interface [nucleotide binding]; DNA binding site
164756012867	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
164756012868	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
164756012869	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756012870	short chain dehydrogenase; Provisional; Region: PRK07774
164756012871	classical (c) SDRs; Region: SDR_c; cd05233
164756012872	NAD(P) binding site [chemical binding]; other site
164756012873	active site
164756012874	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
164756012875	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
164756012876	NAD binding site [chemical binding]; other site
164756012877	catalytic residues [active]
164756012878	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756012879	Cytochrome P450; Region: p450; cl12078
164756012880	short chain dehydrogenase; Provisional; Region: PRK07775
164756012881	classical (c) SDRs; Region: SDR_c; cd05233
164756012882	NAD(P) binding site [chemical binding]; other site
164756012883	active site
164756012884	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756012885	Cytochrome P450; Region: p450; cl12078
164756012886	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
164756012887	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756012888	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
164756012889	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
164756012890	NAD binding site [chemical binding]; other site
164756012891	catalytic Zn binding site [ion binding]; other site
164756012892	substrate binding site [chemical binding]; other site
164756012893	structural Zn binding site [ion binding]; other site
164756012894	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
164756012895	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
164756012896	classical (c) SDRs; Region: SDR_c; cd05233
164756012897	NAD(P) binding site [chemical binding]; other site
164756012898	active site
164756012899	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
164756012900	nucleotide binding site/active site [active]
164756012901	HIT family signature motif; other site
164756012902	catalytic residue [active]
164756012903	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756012904	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
164756012905	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
164756012906	dimer interface [polypeptide binding]; other site
164756012907	phosphorylation site [posttranslational modification]
164756012908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756012909	ATP binding site [chemical binding]; other site
164756012910	Mg2+ binding site [ion binding]; other site
164756012911	G-X-G motif; other site
164756012912	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
164756012913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756012914	active site
164756012915	phosphorylation site [posttranslational modification]
164756012916	intermolecular recognition site; other site
164756012917	dimerization interface [polypeptide binding]; other site
164756012918	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
164756012919	DNA binding site [nucleotide binding]
164756012920	HNH endonuclease; Region: HNH_3; pfam13392
164756012921	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
164756012922	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756012923	trehalose synthase; Region: treS_nterm; TIGR02456
164756012924	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
164756012925	active site
164756012926	catalytic site [active]
164756012927	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
164756012928	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
164756012929	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
164756012930	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
164756012931	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
164756012932	putative hydrophobic ligand binding site [chemical binding]; other site
164756012933	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
164756012934	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
164756012935	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
164756012936	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756012937	catalytic loop [active]
164756012938	iron binding site [ion binding]; other site
164756012939	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
164756012940	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
164756012941	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756012942	short chain dehydrogenase; Provisional; Region: PRK05875
164756012943	classical (c) SDRs; Region: SDR_c; cd05233
164756012944	NAD(P) binding site [chemical binding]; other site
164756012945	active site
164756012946	enoyl-CoA hydratase; Provisional; Region: PRK08290
164756012947	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756012948	substrate binding site [chemical binding]; other site
164756012949	oxyanion hole (OAH) forming residues; other site
164756012950	trimer interface [polypeptide binding]; other site
164756012951	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
164756012952	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
164756012953	active site
164756012954	homotetramer interface [polypeptide binding]; other site
164756012955	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756012956	mce related protein; Region: MCE; pfam02470
164756012957	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756012958	mce related protein; Region: MCE; pfam02470
164756012959	mce related protein; Region: MCE; pfam02470
164756012960	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756012961	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756012962	mce related protein; Region: MCE; pfam02470
164756012963	Vps51/Vps67; Region: Vps51; pfam08700
164756012964	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756012965	mce related protein; Region: MCE; pfam02470
164756012966	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756012967	mce related protein; Region: MCE; pfam02470
164756012968	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756012969	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756012970	Permease; Region: Permease; pfam02405
164756012971	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
164756012972	Permease; Region: Permease; pfam02405
164756012973	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
164756012974	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756012975	NAD(P) binding site [chemical binding]; other site
164756012976	active site
164756012977	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
164756012978	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756012979	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
164756012980	FAD binding site [chemical binding]; other site
164756012981	substrate binding site [chemical binding]; other site
164756012982	catalytic base [active]
164756012983	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756012984	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756012985	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756012986	active site
164756012987	acyl-CoA synthetase; Validated; Region: PRK07867
164756012988	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756012989	acyl-activating enzyme (AAE) consensus motif; other site
164756012990	AMP binding site [chemical binding]; other site
164756012991	active site
164756012992	CoA binding site [chemical binding]; other site
164756012993	Nitronate monooxygenase; Region: NMO; pfam03060
164756012994	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
164756012995	FMN binding site [chemical binding]; other site
164756012996	substrate binding site [chemical binding]; other site
164756012997	putative catalytic residue [active]
164756012998	acyl-CoA synthetase; Validated; Region: PRK07798
164756012999	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756013000	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
164756013001	acyl-activating enzyme (AAE) consensus motif; other site
164756013002	acyl-activating enzyme (AAE) consensus motif; other site
164756013003	putative AMP binding site [chemical binding]; other site
164756013004	putative active site [active]
164756013005	putative CoA binding site [chemical binding]; other site
164756013006	enoyl-CoA hydratase; Provisional; Region: PRK07799
164756013007	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756013008	substrate binding site [chemical binding]; other site
164756013009	oxyanion hole (OAH) forming residues; other site
164756013010	trimer interface [polypeptide binding]; other site
164756013011	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
164756013012	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756013013	Cytochrome P450; Region: p450; cl12078
164756013014	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
164756013015	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756013016	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
164756013017	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
164756013018	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756013019	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
164756013020	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756013021	lipid-transfer protein; Provisional; Region: PRK07937
164756013022	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756013023	active site
164756013024	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
164756013025	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756013026	active site
164756013027	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756013028	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
164756013029	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
164756013030	MOSC domain; Region: MOSC; pfam03473
164756013031	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756013032	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
164756013033	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
164756013034	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
164756013035	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
164756013036	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
164756013037	DXD motif; other site
164756013038	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
164756013039	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
164756013040	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
164756013041	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
164756013042	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
164756013043	short chain dehydrogenase; Provisional; Region: PRK07890
164756013044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756013045	NAD(P) binding site [chemical binding]; other site
164756013046	active site
164756013047	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756013048	putative DNA binding site [nucleotide binding]; other site
164756013049	Transcriptional regulator [Transcription]; Region: IclR; COG1414
164756013050	putative Zn2+ binding site [ion binding]; other site
164756013051	acyl-CoA synthetase; Provisional; Region: PRK13390
164756013052	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756013053	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
164756013054	acyl-activating enzyme (AAE) consensus motif; other site
164756013055	putative AMP binding site [chemical binding]; other site
164756013056	putative active site [active]
164756013057	acyl-activating enzyme (AAE) consensus motif; other site
164756013058	putative CoA binding site [chemical binding]; other site
164756013059	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
164756013060	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
164756013061	NAD(P) binding site [chemical binding]; other site
164756013062	catalytic residues [active]
164756013063	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
164756013064	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
164756013065	NAD binding site [chemical binding]; other site
164756013066	catalytic Zn binding site [ion binding]; other site
164756013067	substrate binding site [chemical binding]; other site
164756013068	structural Zn binding site [ion binding]; other site
164756013069	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756013070	Cytochrome P450; Region: p450; cl12078
164756013071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
164756013072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756013073	ATP binding site [chemical binding]; other site
164756013074	Mg2+ binding site [ion binding]; other site
164756013075	G-X-G motif; other site
164756013076	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756013077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
164756013078	active site
164756013079	phosphorylation site [posttranslational modification]
164756013080	intermolecular recognition site; other site
164756013081	dimerization interface [polypeptide binding]; other site
164756013082	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756013083	DNA binding residues [nucleotide binding]
164756013084	dimerization interface [polypeptide binding]; other site
164756013085	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756013086	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
164756013087	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
164756013088	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756013089	ATP binding site [chemical binding]; other site
164756013090	putative Mg++ binding site [ion binding]; other site
164756013091	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756013092	nucleotide binding region [chemical binding]; other site
164756013093	ATP-binding site [chemical binding]; other site
164756013094	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756013095	active site
164756013096	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
164756013097	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
164756013098	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
164756013099	active site
164756013100	catalytic residues [active]
164756013101	metal binding site [ion binding]; metal-binding site
164756013102	DmpG-like communication domain; Region: DmpG_comm; pfam07836
164756013103	acetaldehyde dehydrogenase; Validated; Region: PRK08300
164756013104	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
164756013105	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
164756013106	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
164756013107	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
164756013108	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756013109	enoyl-CoA hydratase; Region: PLN02864
164756013110	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
164756013111	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
164756013112	dimer interaction site [polypeptide binding]; other site
164756013113	substrate-binding tunnel; other site
164756013114	active site
164756013115	catalytic site [active]
164756013116	substrate binding site [chemical binding]; other site
164756013117	SnoaL-like domain; Region: SnoaL_4; pfam13577
164756013118	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
164756013119	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
164756013120	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
164756013121	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
164756013122	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
164756013123	putative active site [active]
164756013124	putative metal binding site [ion binding]; other site
164756013125	Helix-turn-helix domain; Region: HTH_38; pfam13936
164756013126	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
164756013127	Integrase core domain; Region: rve; pfam00665
164756013128	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
164756013129	lipid-transfer protein; Provisional; Region: PRK07855
164756013130	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756013131	active site
164756013132	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
164756013133	putative active site [active]
164756013134	putative catalytic site [active]
164756013135	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
164756013136	active site
164756013137	catalytic site [active]
164756013138	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
164756013139	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756013140	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756013141	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756013142	active site
164756013143	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756013144	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756013145	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756013146	Cytochrome P450; Region: p450; cl12078
164756013147	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
164756013148	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756013149	dimer interface [polypeptide binding]; other site
164756013150	active site
164756013151	Domain of unknown function (DUF385); Region: DUF385; pfam04075
164756013152	short chain dehydrogenase; Provisional; Region: PRK07791
164756013153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756013154	NAD(P) binding site [chemical binding]; other site
164756013155	active site
164756013156	short chain dehydrogenase; Provisional; Region: PRK07856
164756013157	classical (c) SDRs; Region: SDR_c; cd05233
164756013158	NAD(P) binding site [chemical binding]; other site
164756013159	active site
164756013160	enoyl-CoA hydratase; Provisional; Region: PRK06495
164756013161	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756013162	substrate binding site [chemical binding]; other site
164756013163	oxyanion hole (OAH) forming residues; other site
164756013164	trimer interface [polypeptide binding]; other site
164756013165	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
164756013166	Coenzyme A transferase; Region: CoA_trans; cl17247
164756013167	Nitronate monooxygenase; Region: NMO; pfam03060
164756013168	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
164756013169	FMN binding site [chemical binding]; other site
164756013170	substrate binding site [chemical binding]; other site
164756013171	putative catalytic residue [active]
164756013172	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
164756013173	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
164756013174	NAD binding site [chemical binding]; other site
164756013175	catalytic Zn binding site [ion binding]; other site
164756013176	substrate binding site [chemical binding]; other site
164756013177	structural Zn binding site [ion binding]; other site
164756013178	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
164756013179	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
164756013180	dimer interface [polypeptide binding]; other site
164756013181	active site
164756013182	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756013183	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756013184	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
164756013185	short chain dehydrogenase; Provisional; Region: PRK07831
164756013186	classical (c) SDRs; Region: SDR_c; cd05233
164756013187	NAD(P) binding site [chemical binding]; other site
164756013188	active site
164756013189	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756013190	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756013191	active site
164756013192	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
164756013193	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756013194	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
164756013195	acyl-activating enzyme (AAE) consensus motif; other site
164756013196	putative AMP binding site [chemical binding]; other site
164756013197	putative active site [active]
164756013198	putative CoA binding site [chemical binding]; other site
164756013199	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756013200	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
164756013201	FAD binding site [chemical binding]; other site
164756013202	substrate binding site [chemical binding]; other site
164756013203	catalytic base [active]
164756013204	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756013205	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756013206	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756013207	active site
164756013208	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756013209	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756013210	active site
164756013211	aspartate aminotransferase; Provisional; Region: PRK05764
164756013212	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756013213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756013214	homodimer interface [polypeptide binding]; other site
164756013215	catalytic residue [active]
164756013216	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756013217	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
164756013218	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756013219	acyl-activating enzyme (AAE) consensus motif; other site
164756013220	AMP binding site [chemical binding]; other site
164756013221	active site
164756013222	CoA binding site [chemical binding]; other site
164756013223	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756013224	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
164756013225	NAD(P) binding site [chemical binding]; other site
164756013226	active site
164756013227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756013228	metabolite-proton symporter; Region: 2A0106; TIGR00883
164756013229	putative substrate translocation pore; other site
164756013230	Transcriptional regulator [Transcription]; Region: LysR; COG0583
164756013231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756013232	LysR substrate binding domain; Region: LysR_substrate; pfam03466
164756013233	dimerization interface [polypeptide binding]; other site
164756013234	CsbD-like; Region: CsbD; pfam05532
164756013235	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
164756013236	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
164756013237	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
164756013238	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
164756013239	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
164756013240	active site
164756013241	Fe binding site [ion binding]; other site
164756013242	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
164756013243	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756013244	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
164756013245	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756013246	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
164756013247	Flavin binding site [chemical binding]; other site
164756013248	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
164756013249	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
164756013250	FAD binding pocket [chemical binding]; other site
164756013251	FAD binding motif [chemical binding]; other site
164756013252	phosphate binding motif [ion binding]; other site
164756013253	beta-alpha-beta structure motif; other site
164756013254	NAD(p) ribose binding residues [chemical binding]; other site
164756013255	NAD binding pocket [chemical binding]; other site
164756013256	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
164756013257	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
164756013258	catalytic loop [active]
164756013259	iron binding site [ion binding]; other site
164756013260	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756013261	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756013262	active site
164756013263	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756013264	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756013265	active site
164756013266	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756013267	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756013268	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
164756013269	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
164756013270	Phosphotransferase enzyme family; Region: APH; pfam01636
164756013271	Transcriptional regulators [Transcription]; Region: PurR; COG1609
164756013272	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
164756013273	DNA binding site [nucleotide binding]
164756013274	domain linker motif; other site
164756013275	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
164756013276	putative dimerization interface [polypeptide binding]; other site
164756013277	putative ligand binding site [chemical binding]; other site
164756013278	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
164756013279	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
164756013280	ABC-ATPase subunit  interface; other site
164756013281	dimer interface [polypeptide binding]; other site
164756013282	putative PBP binding regions; other site
164756013283	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
164756013284	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
164756013285	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
164756013286	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
164756013287	intersubunit interface [polypeptide binding]; other site
164756013288	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
164756013289	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
164756013290	active site residue [active]
164756013291	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
164756013292	active site residue [active]
164756013293	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
164756013294	putative FMN binding site [chemical binding]; other site
164756013295	PQQ-like domain; Region: PQQ_2; pfam13360
164756013296	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
164756013297	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
164756013298	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
164756013299	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
164756013300	dimer interface [polypeptide binding]; other site
164756013301	putative PBP binding regions; other site
164756013302	ABC-ATPase subunit  interface; other site
164756013303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756013304	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
164756013305	Walker A/P-loop; other site
164756013306	ATP binding site [chemical binding]; other site
164756013307	Q-loop/lid; other site
164756013308	ABC transporter signature motif; other site
164756013309	Walker B; other site
164756013310	D-loop; other site
164756013311	H-loop/switch region; other site
164756013312	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
164756013313	putative active site [active]
164756013314	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756013315	dimerization interface [polypeptide binding]; other site
164756013316	putative DNA binding site [nucleotide binding]; other site
164756013317	putative Zn2+ binding site [ion binding]; other site
164756013318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756013319	Major Facilitator Superfamily; Region: MFS_1; pfam07690
164756013320	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
164756013321	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
164756013322	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
164756013323	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
164756013324	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
164756013325	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
164756013326	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
164756013327	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
164756013328	active site
164756013329	catalytic site [active]
164756013330	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
164756013331	transmembrane helices; other site
164756013332	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
164756013333	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
164756013334	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
164756013335	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
164756013336	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
164756013337	active site
164756013338	HIGH motif; other site
164756013339	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
164756013340	KMSKS motif; other site
164756013341	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
164756013342	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
164756013343	homotrimer interaction site [polypeptide binding]; other site
164756013344	zinc binding site [ion binding]; other site
164756013345	CDP-binding sites; other site
164756013346	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
164756013347	substrate binding site; other site
164756013348	dimer interface; other site
164756013349	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
164756013350	DNA repair protein RadA; Provisional; Region: PRK11823
164756013351	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
164756013352	Walker A motif; other site
164756013353	ATP binding site [chemical binding]; other site
164756013354	Walker B motif; other site
164756013355	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
164756013356	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
164756013357	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
164756013358	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
164756013359	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
164756013360	active site clefts [active]
164756013361	zinc binding site [ion binding]; other site
164756013362	dimer interface [polypeptide binding]; other site
164756013363	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
164756013364	endonuclease III; Region: ENDO3c; smart00478
164756013365	minor groove reading motif; other site
164756013366	helix-hairpin-helix signature motif; other site
164756013367	substrate binding pocket [chemical binding]; other site
164756013368	active site
164756013369	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
164756013370	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
164756013371	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
164756013372	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756013373	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756013374	metal binding site [ion binding]; metal-binding site
164756013375	active site
164756013376	I-site; other site
164756013377	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
164756013378	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
164756013379	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
164756013380	conserved cys residue [active]
164756013381	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756013382	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756013383	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756013384	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
164756013385	catalytic site [active]
164756013386	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
164756013387	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
164756013388	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
164756013389	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756013390	catalytic core [active]
164756013391	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
164756013392	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
164756013393	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
164756013394	Clp amino terminal domain; Region: Clp_N; pfam02861
164756013395	Clp amino terminal domain; Region: Clp_N; pfam02861
164756013396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756013397	Walker A motif; other site
164756013398	ATP binding site [chemical binding]; other site
164756013399	Walker B motif; other site
164756013400	arginine finger; other site
164756013401	UvrB/uvrC motif; Region: UVR; pfam02151
164756013402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756013403	Walker A motif; other site
164756013404	ATP binding site [chemical binding]; other site
164756013405	Walker B motif; other site
164756013406	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
164756013407	Lsr2; Region: Lsr2; pfam11774
164756013408	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
164756013409	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
164756013410	dimer interface [polypeptide binding]; other site
164756013411	putative anticodon binding site; other site
164756013412	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
164756013413	motif 1; other site
164756013414	dimer interface [polypeptide binding]; other site
164756013415	active site
164756013416	motif 2; other site
164756013417	motif 3; other site
164756013418	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
164756013419	dimer interface [polypeptide binding]; other site
164756013420	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
164756013421	active site
164756013422	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
164756013423	substrate binding site [chemical binding]; other site
164756013424	catalytic residue [active]
164756013425	pantothenate kinase; Reviewed; Region: PRK13318
164756013426	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
164756013427	tetramerization interface [polypeptide binding]; other site
164756013428	active site
164756013429	Pantoate-beta-alanine ligase; Region: PanC; cd00560
164756013430	pantoate--beta-alanine ligase; Region: panC; TIGR00018
164756013431	active site
164756013432	ATP-binding site [chemical binding]; other site
164756013433	pantoate-binding site; other site
164756013434	HXXH motif; other site
164756013435	Rossmann-like domain; Region: Rossmann-like; pfam10727
164756013436	Uncharacterized conserved protein [Function unknown]; Region: COG5495
164756013437	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
164756013438	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
164756013439	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
164756013440	catalytic center binding site [active]
164756013441	ATP binding site [chemical binding]; other site
164756013442	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
164756013443	homooctamer interface [polypeptide binding]; other site
164756013444	active site
164756013445	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
164756013446	dihydropteroate synthase; Region: DHPS; TIGR01496
164756013447	substrate binding pocket [chemical binding]; other site
164756013448	dimer interface [polypeptide binding]; other site
164756013449	inhibitor binding site; inhibition site
164756013450	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
164756013451	homodecamer interface [polypeptide binding]; other site
164756013452	GTP cyclohydrolase I; Provisional; Region: PLN03044
164756013453	active site
164756013454	putative catalytic site residues [active]
164756013455	zinc binding site [ion binding]; other site
164756013456	GTP-CH-I/GFRP interaction surface; other site
164756013457	FtsH Extracellular; Region: FtsH_ext; pfam06480
164756013458	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
164756013459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756013460	Walker A motif; other site
164756013461	ATP binding site [chemical binding]; other site
164756013462	Walker B motif; other site
164756013463	arginine finger; other site
164756013464	Peptidase family M41; Region: Peptidase_M41; pfam01434
164756013465	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756013466	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756013467	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756013468	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
164756013469	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756013470	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
164756013471	putative NAD(P) binding site [chemical binding]; other site
164756013472	catalytic Zn binding site [ion binding]; other site
164756013473	Uncharacterized conserved protein [Function unknown]; Region: COG2968
164756013474	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
164756013475	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756013476	active site
164756013477	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
164756013478	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
164756013479	Ligand Binding Site [chemical binding]; other site
164756013480	TilS substrate binding domain; Region: TilS; pfam09179
164756013481	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
164756013482	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
164756013483	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
164756013484	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
164756013485	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
164756013486	dimer interface [polypeptide binding]; other site
164756013487	substrate binding site [chemical binding]; other site
164756013488	metal binding sites [ion binding]; metal-binding site
164756013489	putative OHCU decarboxylase; Provisional; Region: PRK13798
164756013490	allantoicase; Provisional; Region: PRK13257
164756013491	Allantoicase repeat; Region: Allantoicase; pfam03561
164756013492	Allantoicase repeat; Region: Allantoicase; pfam03561
164756013493	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
164756013494	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
164756013495	putative active site [active]
164756013496	putative metal binding site [ion binding]; other site
164756013497	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
164756013498	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
164756013499	dimer interface [polypeptide binding]; other site
164756013500	NADP binding site [chemical binding]; other site
164756013501	catalytic residues [active]
164756013502	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
164756013503	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
164756013504	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
164756013505	acyl-activating enzyme (AAE) consensus motif; other site
164756013506	AMP binding site [chemical binding]; other site
164756013507	active site
164756013508	CoA binding site [chemical binding]; other site
164756013509	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
164756013510	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
164756013511	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
164756013512	putative CoA binding site [chemical binding]; other site
164756013513	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
164756013514	putative trimer interface [polypeptide binding]; other site
164756013515	putative CoA binding site [chemical binding]; other site
164756013516	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
164756013517	Zn binding site [ion binding]; other site
164756013518	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
164756013519	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756013520	NAD(P) binding site [chemical binding]; other site
164756013521	active site
164756013522	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
164756013523	DNA polymerase III subunit delta'; Validated; Region: PRK07940
164756013524	DNA polymerase III subunit delta'; Validated; Region: PRK08485
164756013525	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
164756013526	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
164756013527	dimerization interface [polypeptide binding]; other site
164756013528	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
164756013529	cyclase homology domain; Region: CHD; cd07302
164756013530	nucleotidyl binding site; other site
164756013531	metal binding site [ion binding]; metal-binding site
164756013532	dimer interface [polypeptide binding]; other site
164756013533	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
164756013534	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
164756013535	active site
164756013536	interdomain interaction site; other site
164756013537	putative metal-binding site [ion binding]; other site
164756013538	nucleotide binding site [chemical binding]; other site
164756013539	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
164756013540	domain I; other site
164756013541	phosphate binding site [ion binding]; other site
164756013542	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
164756013543	domain II; other site
164756013544	domain III; other site
164756013545	nucleotide binding site [chemical binding]; other site
164756013546	DNA binding groove [nucleotide binding]
164756013547	catalytic site [active]
164756013548	domain IV; other site
164756013549	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
164756013550	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
164756013551	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
164756013552	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
164756013553	DNA-binding site [nucleotide binding]; DNA binding site
164756013554	RNA-binding motif; other site
164756013555	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
164756013556	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756013557	ATP binding site [chemical binding]; other site
164756013558	putative Mg++ binding site [ion binding]; other site
164756013559	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756013560	nucleotide binding region [chemical binding]; other site
164756013561	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
164756013562	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
164756013563	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
164756013564	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
164756013565	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
164756013566	ATP binding site [chemical binding]; other site
164756013567	Walker A motif; other site
164756013568	hexamer interface [polypeptide binding]; other site
164756013569	Walker B motif; other site
164756013570	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
164756013571	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
164756013572	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756013573	motif II; other site
164756013574	acetyl-CoA synthetase; Provisional; Region: PRK00174
164756013575	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
164756013576	active site
164756013577	CoA binding site [chemical binding]; other site
164756013578	acyl-activating enzyme (AAE) consensus motif; other site
164756013579	AMP binding site [chemical binding]; other site
164756013580	acetate binding site [chemical binding]; other site
164756013581	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
164756013582	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756013583	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
164756013584	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
164756013585	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
164756013586	putative active site [active]
164756013587	putative CoA binding site [chemical binding]; other site
164756013588	nudix motif; other site
164756013589	metal binding site [ion binding]; metal-binding site
164756013590	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
164756013591	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
164756013592	catalytic residues [active]
164756013593	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
164756013594	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
164756013595	minor groove reading motif; other site
164756013596	helix-hairpin-helix signature motif; other site
164756013597	substrate binding pocket [chemical binding]; other site
164756013598	active site
164756013599	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
164756013600	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
164756013601	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
164756013602	ligand binding site [chemical binding]; other site
164756013603	flexible hinge region; other site
164756013604	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
164756013605	putative switch regulator; other site
164756013606	non-specific DNA interactions [nucleotide binding]; other site
164756013607	DNA binding site [nucleotide binding]
164756013608	sequence specific DNA binding site [nucleotide binding]; other site
164756013609	putative cAMP binding site [chemical binding]; other site
164756013610	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756013611	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
164756013612	homotrimer interaction site [polypeptide binding]; other site
164756013613	putative active site [active]
164756013614	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
164756013615	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
164756013616	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
164756013617	P loop; other site
164756013618	Nucleotide binding site [chemical binding]; other site
164756013619	DTAP/Switch II; other site
164756013620	Switch I; other site
164756013621	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
164756013622	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
164756013623	DTAP/Switch II; other site
164756013624	Switch I; other site
164756013625	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756013626	Transcription factor WhiB; Region: Whib; pfam02467
164756013627	Transglycosylase; Region: Transgly; pfam00912
164756013628	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
164756013629	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
164756013630	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
164756013631	phosphodiesterase YaeI; Provisional; Region: PRK11340
164756013632	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
164756013633	putative active site [active]
164756013634	putative metal binding site [ion binding]; other site
164756013635	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
164756013636	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
164756013637	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756013638	catalytic residue [active]
164756013639	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
164756013640	active site
164756013641	DNA binding site [nucleotide binding]
164756013642	Int/Topo IB signature motif; other site
164756013643	Helix-turn-helix domain; Region: HTH_17; pfam12728
164756013644	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756013645	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756013646	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756013647	CoenzymeA binding site [chemical binding]; other site
164756013648	subunit interaction site [polypeptide binding]; other site
164756013649	PHB binding site; other site
164756013650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756013651	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756013652	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
164756013653	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
164756013654	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
164756013655	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756013656	active site
164756013657	ATP binding site [chemical binding]; other site
164756013658	substrate binding site [chemical binding]; other site
164756013659	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
164756013660	substrate binding site [chemical binding]; other site
164756013661	activation loop (A-loop); other site
164756013662	activation loop (A-loop); other site
164756013663	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756013664	MULE transposase domain; Region: MULE; pfam10551
164756013665	Cytochrome P450; Region: p450; cl12078
164756013666	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756013667	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
164756013668	active site
164756013669	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
164756013670	catalytic triad [active]
164756013671	dimer interface [polypeptide binding]; other site
164756013672	putative methyltransferase; Provisional; Region: PRK14967
164756013673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756013674	S-adenosylmethionine binding site [chemical binding]; other site
164756013675	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756013676	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
164756013677	Yqey-like protein; Region: YqeY; pfam09424
164756013678	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
164756013679	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
164756013680	MoxR-like ATPases [General function prediction only]; Region: COG0714
164756013681	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756013682	Walker A motif; other site
164756013683	ATP binding site [chemical binding]; other site
164756013684	Walker B motif; other site
164756013685	arginine finger; other site
164756013686	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
164756013687	Protein of unknown function DUF58; Region: DUF58; pfam01882
164756013688	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
164756013689	Predicted membrane protein/domain [Function unknown]; Region: COG1714
164756013690	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
164756013691	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
164756013692	putative active site [active]
164756013693	putative FMN binding site [chemical binding]; other site
164756013694	putative substrate binding site [chemical binding]; other site
164756013695	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
164756013696	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
164756013697	dimer interface [polypeptide binding]; other site
164756013698	PYR/PP interface [polypeptide binding]; other site
164756013699	TPP binding site [chemical binding]; other site
164756013700	substrate binding site [chemical binding]; other site
164756013701	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
164756013702	Domain of unknown function; Region: EKR; pfam10371
164756013703	4Fe-4S binding domain; Region: Fer4_6; pfam12837
164756013704	4Fe-4S binding domain; Region: Fer4; pfam00037
164756013705	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
164756013706	TPP-binding site [chemical binding]; other site
164756013707	dimer interface [polypeptide binding]; other site
164756013708	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
164756013709	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756013710	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756013711	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
164756013712	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
164756013713	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
164756013714	Transcriptional regulators [Transcription]; Region: FadR; COG2186
164756013715	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756013716	DNA-binding site [nucleotide binding]; DNA binding site
164756013717	FCD domain; Region: FCD; pfam07729
164756013718	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
164756013719	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
164756013720	Na binding site [ion binding]; other site
164756013721	putative substrate binding site [chemical binding]; other site
164756013722	Predicted transcriptional regulators [Transcription]; Region: COG1695
164756013723	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
164756013724	Predicted transcriptional regulators [Transcription]; Region: COG1695
164756013725	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756013726	dimerization interface [polypeptide binding]; other site
164756013727	putative DNA binding site [nucleotide binding]; other site
164756013728	putative Zn2+ binding site [ion binding]; other site
164756013729	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
164756013730	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
164756013731	active site
164756013732	catalytic tetrad [active]
164756013733	glycerol kinase; Provisional; Region: glpK; PRK00047
164756013734	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
164756013735	nucleotide binding site [chemical binding]; other site
164756013736	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756013737	S-adenosylmethionine binding site [chemical binding]; other site
164756013738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756013739	metabolite-proton symporter; Region: 2A0106; TIGR00883
164756013740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756013741	S-adenosylmethionine binding site [chemical binding]; other site
164756013742	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
164756013743	ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343
164756013744	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756013745	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756013746	catalytic residue [active]
164756013747	catalytic residue [active]
164756013748	Uncharacterized conserved protein [Function unknown]; Region: COG4301
164756013749	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
164756013750	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
164756013751	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
164756013752	putative active site [active]
164756013753	putative dimer interface [polypeptide binding]; other site
164756013754	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
164756013755	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
164756013756	ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444
164756013757	PknH-like extracellular domain; Region: PknH_C; pfam14032
164756013758	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
164756013759	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
164756013760	putative DNA binding helix; other site
164756013761	metal binding site 2 [ion binding]; metal-binding site
164756013762	metal binding site 1 [ion binding]; metal-binding site
164756013763	dimer interface [polypeptide binding]; other site
164756013764	structural Zn2+ binding site [ion binding]; other site
164756013765	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
164756013766	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
164756013767	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
164756013768	aspartate kinase; Reviewed; Region: PRK06635
164756013769	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
164756013770	putative nucleotide binding site [chemical binding]; other site
164756013771	putative catalytic residues [active]
164756013772	putative Mg ion binding site [ion binding]; other site
164756013773	putative aspartate binding site [chemical binding]; other site
164756013774	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
164756013775	putative allosteric regulatory site; other site
164756013776	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
164756013777	putative allosteric regulatory residue; other site
164756013778	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
164756013779	putative FMN binding site [chemical binding]; other site
164756013780	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
164756013781	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
164756013782	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
164756013783	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756013784	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
164756013785	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
164756013786	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
164756013787	active site
164756013788	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
164756013789	domain_subunit interface; other site
164756013790	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
164756013791	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
164756013792	active site
164756013793	FMN binding site [chemical binding]; other site
164756013794	substrate binding site [chemical binding]; other site
164756013795	3Fe-4S cluster binding site [ion binding]; other site
164756013796	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
164756013797	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
164756013798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756013799	non-specific DNA binding site [nucleotide binding]; other site
164756013800	salt bridge; other site
164756013801	sequence-specific DNA binding site [nucleotide binding]; other site
164756013802	Cupin domain; Region: Cupin_2; pfam07883
164756013803	2-isopropylmalate synthase; Validated; Region: PRK03739
164756013804	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
164756013805	active site
164756013806	catalytic residues [active]
164756013807	metal binding site [ion binding]; metal-binding site
164756013808	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
164756013809	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
164756013810	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
164756013811	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
164756013812	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
164756013813	active site
164756013814	catalytic site [active]
164756013815	substrate binding site [chemical binding]; other site
164756013816	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
164756013817	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
164756013818	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
164756013819	catalytic triad [active]
164756013820	recombination protein RecR; Reviewed; Region: recR; PRK00076
164756013821	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
164756013822	RecR protein; Region: RecR; pfam02132
164756013823	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
164756013824	putative active site [active]
164756013825	putative metal-binding site [ion binding]; other site
164756013826	tetramer interface [polypeptide binding]; other site
164756013827	hypothetical protein; Validated; Region: PRK00153
164756013828	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
164756013829	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
164756013830	active site
164756013831	metal binding site [ion binding]; metal-binding site
164756013832	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
164756013833	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
164756013834	FAD binding domain; Region: FAD_binding_4; pfam01565
164756013835	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
164756013836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756013837	S-adenosylmethionine binding site [chemical binding]; other site
164756013838	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
164756013839	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756013840	Walker A motif; other site
164756013841	ATP binding site [chemical binding]; other site
164756013842	Walker B motif; other site
164756013843	arginine finger; other site
164756013844	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
164756013845	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
164756013846	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
164756013847	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756013848	catalytic residue [active]
164756013849	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
164756013850	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
164756013851	protein binding site [polypeptide binding]; other site
164756013852	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756013853	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
164756013854	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
164756013855	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
164756013856	nucleotide binding site [chemical binding]; other site
164756013857	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
164756013858	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
164756013859	active site
164756013860	DNA binding site [nucleotide binding]
164756013861	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
164756013862	DNA binding site [nucleotide binding]
164756013863	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756013864	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756013865	active site
164756013866	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756013867	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756013868	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
164756013869	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756013870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756013871	NAD(P) binding site [chemical binding]; other site
164756013872	active site
164756013873	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
164756013874	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756013875	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756013876	DNA binding residues [nucleotide binding]
164756013877	AAA ATPase domain; Region: AAA_16; pfam13191
164756013878	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
164756013879	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
164756013880	DNA binding residues [nucleotide binding]
164756013881	dimerization interface [polypeptide binding]; other site
164756013882	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
164756013883	putative FMN binding site [chemical binding]; other site
164756013884	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
164756013885	Transposase; Region: DEDD_Tnp_IS110; pfam01548
164756013886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
164756013887	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
164756013888	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756013889	classical (c) SDRs; Region: SDR_c; cd05233
164756013890	NAD(P) binding site [chemical binding]; other site
164756013891	active site
164756013892	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756013893	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756013894	Cytochrome P450; Region: p450; cl12078
164756013895	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756013896	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756013897	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
164756013898	active site
164756013899	metal binding site [ion binding]; metal-binding site
164756013900	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
164756013901	classical (c) SDRs; Region: SDR_c; cd05233
164756013902	NAD(P) binding site [chemical binding]; other site
164756013903	active site
164756013904	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
164756013905	FMN binding site [chemical binding]; other site
164756013906	dimer interface [polypeptide binding]; other site
164756013907	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
164756013908	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756013909	short chain dehydrogenase; Provisional; Region: PRK08303
164756013910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756013911	NAD(P) binding site [chemical binding]; other site
164756013912	active site
164756013913	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756013914	Cytochrome P450; Region: p450; cl12078
164756013915	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756013916	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756013917	NAD(P) binding site [chemical binding]; other site
164756013918	active site
164756013919	choline dehydrogenase; Validated; Region: PRK02106
164756013920	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756013921	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
164756013922	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
164756013923	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
164756013924	active site
164756013925	DNA binding site [nucleotide binding]
164756013926	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
164756013927	DNA binding site [nucleotide binding]
164756013928	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
164756013929	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
164756013930	homodimer interface [polypeptide binding]; other site
164756013931	putative substrate binding pocket [chemical binding]; other site
164756013932	diiron center [ion binding]; other site
164756013933	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
164756013934	active site
164756013935	HIGH motif; other site
164756013936	nucleotide binding site [chemical binding]; other site
164756013937	active site
164756013938	KMSKS motif; other site
164756013939	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
164756013940	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756013941	substrate binding pocket [chemical binding]; other site
164756013942	membrane-bound complex binding site; other site
164756013943	hinge residues; other site
164756013944	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
164756013945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756013946	dimer interface [polypeptide binding]; other site
164756013947	conserved gate region; other site
164756013948	putative PBP binding loops; other site
164756013949	ABC-ATPase subunit interface; other site
164756013950	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
164756013951	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
164756013952	Walker A/P-loop; other site
164756013953	ATP binding site [chemical binding]; other site
164756013954	Q-loop/lid; other site
164756013955	ABC transporter signature motif; other site
164756013956	Walker B; other site
164756013957	D-loop; other site
164756013958	H-loop/switch region; other site
164756013959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756013960	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756013961	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
164756013962	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
164756013963	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756013964	Cytochrome P450; Region: p450; cl12078
164756013965	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
164756013966	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
164756013967	haloalkane dehalogenase; Provisional; Region: PRK00870
164756013968	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
164756013969	PE-PPE domain; Region: PE-PPE; pfam08237
164756013970	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
164756013971	Dehydratase small subunit; Region: Dehydratase_SU; pfam02287
164756013972	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
164756013973	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
164756013974	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
164756013975	alpha-beta subunit interface [polypeptide binding]; other site
164756013976	alpha-gamma subunit interface [polypeptide binding]; other site
164756013977	active site
164756013978	substrate and K+ binding site; other site
164756013979	K+ binding site [ion binding]; other site
164756013980	cobalamin binding site [chemical binding]; other site
164756013981	Dehydratase medium subunit; Region: Dehydratase_MU; cl17703
164756013982	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
164756013983	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
164756013984	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
164756013985	Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590
164756013986	active site
164756013987	Zn binding site [ion binding]; other site
164756013988	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
164756013989	prephenate dehydrogenase; Validated; Region: PRK06545
164756013990	prephenate dehydrogenase; Validated; Region: PRK08507
164756013991	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
164756013992	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756013993	dimer interface [polypeptide binding]; other site
164756013994	ABC-ATPase subunit interface; other site
164756013995	putative PBP binding loops; other site
164756013996	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
164756013997	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
164756013998	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
164756013999	Walker A/P-loop; other site
164756014000	ATP binding site [chemical binding]; other site
164756014001	Q-loop/lid; other site
164756014002	ABC transporter signature motif; other site
164756014003	Walker B; other site
164756014004	D-loop; other site
164756014005	H-loop/switch region; other site
164756014006	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
164756014007	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
164756014008	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
164756014009	putative active site [active]
164756014010	putative substrate binding site [chemical binding]; other site
164756014011	ATP binding site [chemical binding]; other site
164756014012	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756014013	catalytic core [active]
164756014014	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
164756014015	classical (c) SDRs; Region: SDR_c; cd05233
164756014016	NAD(P) binding site [chemical binding]; other site
164756014017	active site
164756014018	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
164756014019	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
164756014020	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
164756014021	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
164756014022	Predicted transcriptional regulators [Transcription]; Region: COG1733
164756014023	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756014024	dimerization interface [polypeptide binding]; other site
164756014025	putative Zn2+ binding site [ion binding]; other site
164756014026	putative DNA binding site [nucleotide binding]; other site
164756014027	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
164756014028	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
164756014029	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
164756014030	Protein of unknown function (DUF419); Region: DUF419; cl15265
164756014031	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
164756014032	active site
164756014033	metal binding site [ion binding]; metal-binding site
164756014034	homotetramer interface [polypeptide binding]; other site
164756014035	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756014036	Cutinase; Region: Cutinase; pfam01083
164756014037	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756014038	Ligand Binding Site [chemical binding]; other site
164756014039	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
164756014040	Ligand Binding Site [chemical binding]; other site
164756014041	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
164756014042	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756014043	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756014044	homodimer interface [polypeptide binding]; other site
164756014045	catalytic residue [active]
164756014046	GXWXG protein; Region: GXWXG; pfam14231
164756014047	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
164756014048	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
164756014049	TIGR03086 family protein; Region: TIGR03086
164756014050	enoyl-CoA hydratase; Provisional; Region: PRK06142
164756014051	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
164756014052	substrate binding site [chemical binding]; other site
164756014053	oxyanion hole (OAH) forming residues; other site
164756014054	trimer interface [polypeptide binding]; other site
164756014055	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756014056	MarR family; Region: MarR; pfam01047
164756014057	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
164756014058	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
164756014059	NAD(P) binding site [chemical binding]; other site
164756014060	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
164756014061	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
164756014062	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756014063	catalytic residue [active]
164756014064	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
164756014065	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
164756014066	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
164756014067	Walker A/P-loop; other site
164756014068	ATP binding site [chemical binding]; other site
164756014069	Q-loop/lid; other site
164756014070	ABC transporter signature motif; other site
164756014071	Walker B; other site
164756014072	D-loop; other site
164756014073	H-loop/switch region; other site
164756014074	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
164756014075	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756014076	active site
164756014077	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
164756014078	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
164756014079	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
164756014080	Phosphotransferase enzyme family; Region: APH; pfam01636
164756014081	Uncharacterized conserved protein [Function unknown]; Region: COG2128
164756014082	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
164756014083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756014084	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
164756014085	DNA-binding site [nucleotide binding]; DNA binding site
164756014086	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
164756014087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756014088	homodimer interface [polypeptide binding]; other site
164756014089	catalytic residue [active]
164756014090	Predicted membrane protein [Function unknown]; Region: COG2246
164756014091	GtrA-like protein; Region: GtrA; pfam04138
164756014092	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
164756014093	FAD binding domain; Region: FAD_binding_4; pfam01565
164756014094	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
164756014095	short chain dehydrogenase; Provisional; Region: PRK07904
164756014096	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
164756014097	NAD(P) binding site [chemical binding]; other site
164756014098	active site
164756014099	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
164756014100	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
164756014101	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
164756014102	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
164756014103	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
164756014104	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756014105	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756014106	active site
164756014107	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756014108	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756014109	active site
164756014110	ATP binding site [chemical binding]; other site
164756014111	substrate binding site [chemical binding]; other site
164756014112	activation loop (A-loop); other site
164756014113	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
164756014114	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
164756014115	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
164756014116	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756014117	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
164756014118	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
164756014119	active site
164756014120	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
164756014121	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
164756014122	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
164756014123	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
164756014124	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
164756014125	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
164756014126	acyl-activating enzyme (AAE) consensus motif; other site
164756014127	active site
164756014128	Cutinase; Region: Cutinase; pfam01083
164756014129	Putative esterase; Region: Esterase; pfam00756
164756014130	Putative esterase; Region: Esterase; pfam00756
164756014131	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
164756014132	UbiA prenyltransferase family; Region: UbiA; pfam01040
164756014133	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
164756014134	active site
164756014135	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
164756014136	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
164756014137	active site
164756014138	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
164756014139	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756014140	UDP-galactopyranose mutase; Region: GLF; pfam03275
164756014141	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
164756014142	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
164756014143	amidase catalytic site [active]
164756014144	Zn binding residues [ion binding]; other site
164756014145	substrate binding site [chemical binding]; other site
164756014146	LGFP repeat; Region: LGFP; pfam08310
164756014147	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
164756014148	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756014149	active site
164756014150	motif I; other site
164756014151	motif II; other site
164756014152	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
164756014153	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756014154	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
164756014155	putative acyl-acceptor binding pocket; other site
164756014156	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756014157	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
164756014158	putative acyl-acceptor binding pocket; other site
164756014159	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
164756014160	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
164756014161	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756014162	iron-sulfur cluster [ion binding]; other site
164756014163	[2Fe-2S] cluster binding site [ion binding]; other site
164756014164	seryl-tRNA synthetase; Provisional; Region: PRK05431
164756014165	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
164756014166	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
164756014167	dimer interface [polypeptide binding]; other site
164756014168	active site
164756014169	motif 1; other site
164756014170	motif 2; other site
164756014171	motif 3; other site
164756014172	Septum formation; Region: Septum_form; pfam13845
164756014173	Septum formation; Region: Septum_form; pfam13845
164756014174	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
164756014175	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756014176	catalytic core [active]
164756014177	prephenate dehydratase; Provisional; Region: PRK11898
164756014178	Prephenate dehydratase; Region: PDT; pfam00800
164756014179	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
164756014180	putative L-Phe binding site [chemical binding]; other site
164756014181	CAAX protease self-immunity; Region: Abi; pfam02517
164756014182	Transcriptional regulator [Transcription]; Region: LytR; COG1316
164756014183	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
164756014184	Ferritin-like domain; Region: Ferritin; pfam00210
164756014185	ferroxidase diiron center [ion binding]; other site
164756014186	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
164756014187	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
164756014188	putative active site [active]
164756014189	catalytic site [active]
164756014190	putative metal binding site [ion binding]; other site
164756014191	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
164756014192	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
164756014193	active site residue [active]
164756014194	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
164756014195	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
164756014196	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
164756014197	Predicted membrane protein [Function unknown]; Region: COG2119
164756014198	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
164756014199	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
164756014200	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
164756014201	CopC domain; Region: CopC; pfam04234
164756014202	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
164756014203	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756014204	DNA binding residues [nucleotide binding]
164756014205	dimer interface [polypeptide binding]; other site
164756014206	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
164756014207	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
164756014208	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756014209	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756014210	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014211	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014212	DNA polymerase IV; Validated; Region: PRK03858
164756014213	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
164756014214	active site
164756014215	DNA binding site [nucleotide binding]
164756014216	hydroperoxidase II; Provisional; Region: katE; PRK11249
164756014217	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
164756014218	heme binding pocket [chemical binding]; other site
164756014219	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
164756014220	domain interactions; other site
164756014221	hypothetical protein; Provisional; Region: PRK07945
164756014222	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
164756014223	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
164756014224	active site
164756014225	TIGR03086 family protein; Region: TIGR03086
164756014226	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
164756014227	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
164756014228	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756014229	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
164756014230	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756014231	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
164756014232	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
164756014233	active site
164756014234	dimer interface [polypeptide binding]; other site
164756014235	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
164756014236	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
164756014237	active site
164756014238	FMN binding site [chemical binding]; other site
164756014239	substrate binding site [chemical binding]; other site
164756014240	3Fe-4S cluster binding site [ion binding]; other site
164756014241	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
164756014242	domain interface; other site
164756014243	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756014244	CoenzymeA binding site [chemical binding]; other site
164756014245	subunit interaction site [polypeptide binding]; other site
164756014246	PHB binding site; other site
164756014247	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
164756014248	amphipathic channel; other site
164756014249	Asn-Pro-Ala signature motifs; other site
164756014250	Protein of unknown function (DUF732); Region: DUF732; pfam05305
164756014251	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
164756014252	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
164756014253	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
164756014254	dimerization interface [polypeptide binding]; other site
164756014255	DPS ferroxidase diiron center [ion binding]; other site
164756014256	ion pore; other site
164756014257	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
164756014258	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
164756014259	minor groove reading motif; other site
164756014260	helix-hairpin-helix signature motif; other site
164756014261	active site
164756014262	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
164756014263	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
164756014264	substrate binding pocket [chemical binding]; other site
164756014265	chain length determination region; other site
164756014266	substrate-Mg2+ binding site; other site
164756014267	catalytic residues [active]
164756014268	aspartate-rich region 1; other site
164756014269	active site lid residues [active]
164756014270	aspartate-rich region 2; other site
164756014271	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756014272	phytoene desaturase; Region: crtI_fam; TIGR02734
164756014273	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
164756014274	active site lid residues [active]
164756014275	substrate binding pocket [chemical binding]; other site
164756014276	catalytic residues [active]
164756014277	substrate-Mg2+ binding site; other site
164756014278	aspartate-rich region 1; other site
164756014279	aspartate-rich region 2; other site
164756014280	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
164756014281	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
164756014282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
164756014283	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
164756014284	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
164756014285	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756014286	iron-sulfur cluster [ion binding]; other site
164756014287	[2Fe-2S] cluster binding site [ion binding]; other site
164756014288	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
164756014289	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
164756014290	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
164756014291	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
164756014292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
164756014293	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
164756014294	hydrophobic ligand binding site; other site
164756014295	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
164756014296	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
164756014297	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
164756014298	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756014299	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
164756014300	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
164756014301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756014302	NAD(P) binding site [chemical binding]; other site
164756014303	active site
164756014304	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756014305	SelR domain; Region: SelR; pfam01641
164756014306	methionine sulfoxide reductase B; Provisional; Region: PRK00222
164756014307	methionine sulfoxide reductase A; Provisional; Region: PRK14054
164756014308	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756014309	Cytochrome P450; Region: p450; cl12078
164756014310	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014311	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014312	Methyltransferase domain; Region: Methyltransf_24; pfam13578
164756014313	FOG: CBS domain [General function prediction only]; Region: COG0517
164756014314	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
164756014315	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
164756014316	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756014317	dimerization interface [polypeptide binding]; other site
164756014318	putative Zn2+ binding site [ion binding]; other site
164756014319	putative DNA binding site [nucleotide binding]; other site
164756014320	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
164756014321	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
164756014322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
164756014323	S-adenosylmethionine binding site [chemical binding]; other site
164756014324	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
164756014325	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
164756014326	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
164756014327	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756014328	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756014329	active site
164756014330	Domain of unknown function (DUF427); Region: DUF427; cl00998
164756014331	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
164756014332	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756014333	NAD binding site [chemical binding]; other site
164756014334	catalytic Zn binding site [ion binding]; other site
164756014335	structural Zn binding site [ion binding]; other site
164756014336	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
164756014337	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
164756014338	Isochorismatase family; Region: Isochorismatase; pfam00857
164756014339	catalytic triad [active]
164756014340	metal binding site [ion binding]; metal-binding site
164756014341	conserved cis-peptide bond; other site
164756014342	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
164756014343	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
164756014344	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
164756014345	active site
164756014346	catalytic site [active]
164756014347	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014348	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014349	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
164756014350	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756014351	active site
164756014352	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
164756014353	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756014354	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756014355	active site
164756014356	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
164756014357	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
164756014358	trehalose synthase; Region: treS_nterm; TIGR02456
164756014359	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
164756014360	active site
164756014361	catalytic site [active]
164756014362	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
164756014363	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
164756014364	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756014365	active site
164756014366	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
164756014367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756014368	Walker A/P-loop; other site
164756014369	ATP binding site [chemical binding]; other site
164756014370	Q-loop/lid; other site
164756014371	ABC transporter signature motif; other site
164756014372	Walker B; other site
164756014373	D-loop; other site
164756014374	H-loop/switch region; other site
164756014375	TOBE domain; Region: TOBE_2; pfam08402
164756014376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756014377	dimer interface [polypeptide binding]; other site
164756014378	conserved gate region; other site
164756014379	putative PBP binding loops; other site
164756014380	ABC-ATPase subunit interface; other site
164756014381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
164756014382	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
164756014383	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
164756014384	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
164756014385	Cupin domain; Region: Cupin_2; cl17218
164756014386	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
164756014387	putative hydrophobic ligand binding site [chemical binding]; other site
164756014388	protein interface [polypeptide binding]; other site
164756014389	gate; other site
164756014390	dihydroxyacetone kinase; Provisional; Region: PRK14479
164756014391	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
164756014392	DAK2 domain; Region: Dak2; pfam02734
164756014393	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014394	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014395	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
164756014396	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
164756014397	elongation factor G; Reviewed; Region: PRK12740
164756014398	G1 box; other site
164756014399	putative GEF interaction site [polypeptide binding]; other site
164756014400	GTP/Mg2+ binding site [chemical binding]; other site
164756014401	Switch I region; other site
164756014402	G2 box; other site
164756014403	G3 box; other site
164756014404	Switch II region; other site
164756014405	G4 box; other site
164756014406	G5 box; other site
164756014407	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
164756014408	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
164756014409	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
164756014410	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
164756014411	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
164756014412	mce related protein; Region: MCE; pfam02470
164756014413	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
164756014414	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
164756014415	catalytic core [active]
164756014416	MMPL family; Region: MMPL; pfam03176
164756014417	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
164756014418	Rhomboid family; Region: Rhomboid; pfam01694
164756014419	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
164756014420	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756014421	active site
164756014422	amidase; Validated; Region: PRK06565
164756014423	Amidase; Region: Amidase; cl11426
164756014424	Cupin; Region: Cupin_6; pfam12852
164756014425	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
164756014426	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
164756014427	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
164756014428	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
164756014429	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
164756014430	Cytochrome P450; Region: p450; cl12078
164756014431	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
164756014432	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
164756014433	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
164756014434	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756014435	anti sigma factor interaction site; other site
164756014436	regulatory phosphorylation site [posttranslational modification]; other site
164756014437	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
164756014438	B12 binding domain; Region: B12-binding_2; pfam02607
164756014439	B12 binding domain; Region: B12-binding; pfam02310
164756014440	B12 binding site [chemical binding]; other site
164756014441	von Willebrand factor type A domain; Region: VWA_2; pfam13519
164756014442	Protein of unknown function DUF58; Region: DUF58; pfam01882
164756014443	MoxR-like ATPases [General function prediction only]; Region: COG0714
164756014444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756014445	Walker A motif; other site
164756014446	ATP binding site [chemical binding]; other site
164756014447	Walker B motif; other site
164756014448	arginine finger; other site
164756014449	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014450	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014451	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756014452	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014453	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014454	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
164756014455	putative hydrophobic ligand binding site [chemical binding]; other site
164756014456	short chain dehydrogenase; Provisional; Region: PRK06197
164756014457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756014458	NAD(P) binding site [chemical binding]; other site
164756014459	active site
164756014460	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
164756014461	active site
164756014462	catalytic triad [active]
164756014463	oxyanion hole [active]
164756014464	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
164756014465	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
164756014466	amino acid transporter; Region: 2A0306; TIGR00909
164756014467	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756014468	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
164756014469	active site
164756014470	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756014471	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756014472	PAS fold; Region: PAS_3; pfam08447
164756014473	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
164756014474	putative active site [active]
164756014475	heme pocket [chemical binding]; other site
164756014476	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
164756014477	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
164756014478	anti sigma factor interaction site; other site
164756014479	regulatory phosphorylation site [posttranslational modification]; other site
164756014480	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
164756014481	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
164756014482	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756014483	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756014484	active site
164756014485	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756014486	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756014487	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756014488	active site
164756014489	hypothetical protein; Validated; Region: PRK07198
164756014490	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
164756014491	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
164756014492	dimerization interface [polypeptide binding]; other site
164756014493	active site
164756014494	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
164756014495	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
164756014496	active site
164756014497	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
164756014498	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756014499	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756014500	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
164756014501	active site
164756014502	metal binding site [ion binding]; metal-binding site
164756014503	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
164756014504	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
164756014505	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
164756014506	FAD binding domain; Region: FAD_binding_2; pfam00890
164756014507	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
164756014508	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
164756014509	Uncharacterized conserved protein [Function unknown]; Region: COG0397
164756014510	hypothetical protein; Validated; Region: PRK00029
164756014511	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
164756014512	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
164756014513	homodimer interface [polypeptide binding]; other site
164756014514	homotetramer interface [polypeptide binding]; other site
164756014515	active site pocket [active]
164756014516	cleavage site
164756014517	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014518	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014519	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756014520	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756014521	metal binding site [ion binding]; metal-binding site
164756014522	active site
164756014523	I-site; other site
164756014524	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756014525	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756014526	active site
164756014527	short chain dehydrogenase; Provisional; Region: PRK05872
164756014528	classical (c) SDRs; Region: SDR_c; cd05233
164756014529	NAD(P) binding site [chemical binding]; other site
164756014530	active site
164756014531	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
164756014532	active site
164756014533	metal binding site [ion binding]; metal-binding site
164756014534	selenophosphate synthetase; Provisional; Region: PRK00943
164756014535	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
164756014536	dimerization interface [polypeptide binding]; other site
164756014537	putative ATP binding site [chemical binding]; other site
164756014538	selenocysteine synthase; Provisional; Region: PRK04311
164756014539	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
164756014540	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
164756014541	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
164756014542	catalytic residue [active]
164756014543	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
164756014544	G1 box; other site
164756014545	putative GEF interaction site [polypeptide binding]; other site
164756014546	GTP/Mg2+ binding site [chemical binding]; other site
164756014547	Switch I region; other site
164756014548	G2 box; other site
164756014549	G3 box; other site
164756014550	Switch II region; other site
164756014551	G4 box; other site
164756014552	G5 box; other site
164756014553	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
164756014554	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
164756014555	Transcriptional regulator PadR-like family; Region: PadR; cl17335
164756014556	Predicted transcriptional regulators [Transcription]; Region: COG1695
164756014557	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756014558	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756014559	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756014560	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
164756014561	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
164756014562	molybdopterin cofactor binding site; other site
164756014563	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
164756014564	4Fe-4S binding domain; Region: Fer4_6; pfam12837
164756014565	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
164756014566	Cutinase; Region: Cutinase; pfam01083
164756014567	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756014568	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
164756014569	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
164756014570	Uncharacterized conserved protein [Function unknown]; Region: COG0398
164756014571	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
164756014572	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
164756014573	nucleotide binding site [chemical binding]; other site
164756014574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
164756014575	SnoaL-like domain; Region: SnoaL_2; pfam12680
164756014576	classical (c) SDRs; Region: SDR_c; cd05233
164756014577	NAD(P) binding site [chemical binding]; other site
164756014578	active site
164756014579	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
164756014580	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
164756014581	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014582	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014583	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
164756014584	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
164756014585	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
164756014586	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
164756014587	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756014588	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
164756014589	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
164756014590	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
164756014591	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
164756014592	acyl-activating enzyme (AAE) consensus motif; other site
164756014593	active site
164756014594	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
164756014595	GAF domain; Region: GAF_3; pfam13492
164756014596	ANTAR domain; Region: ANTAR; pfam03861
164756014597	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
164756014598	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
164756014599	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
164756014600	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
164756014601	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
164756014602	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
164756014603	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014604	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014605	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
164756014606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756014607	putative substrate translocation pore; other site
164756014608	Transcriptional regulators [Transcription]; Region: MarR; COG1846
164756014609	MarR family; Region: MarR_2; pfam12802
164756014610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756014611	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
164756014612	NAD(P) binding site [chemical binding]; other site
164756014613	active site
164756014614	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756014615	MarR family; Region: MarR_2; cl17246
164756014616	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
164756014617	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756014618	putative active site [active]
164756014619	putative metal binding site [ion binding]; other site
164756014620	Cupin superfamily protein; Region: Cupin_4; pfam08007
164756014621	Cupin-like domain; Region: Cupin_8; pfam13621
164756014622	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
164756014623	Domain of unknown function DUF302; Region: DUF302; cl01364
164756014624	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
164756014625	CoenzymeA binding site [chemical binding]; other site
164756014626	subunit interaction site [polypeptide binding]; other site
164756014627	PHB binding site; other site
164756014628	NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231
164756014629	NmrA-like family; Region: NmrA; pfam05368
164756014630	putative NADP binding site [chemical binding]; other site
164756014631	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014633	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
164756014634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756014635	putative substrate translocation pore; other site
164756014636	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
164756014637	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
164756014638	thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887
164756014639	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
164756014640	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756014641	ATP binding site [chemical binding]; other site
164756014642	putative Mg++ binding site [ion binding]; other site
164756014643	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756014644	nucleotide binding region [chemical binding]; other site
164756014645	ATP-binding site [chemical binding]; other site
164756014646	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
164756014647	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
164756014648	putative active site [active]
164756014649	putative CoA binding site [chemical binding]; other site
164756014650	nudix motif; other site
164756014651	metal binding site [ion binding]; metal-binding site
164756014652	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
164756014653	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
164756014654	tetramer interface [polypeptide binding]; other site
164756014655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
164756014656	catalytic residue [active]
164756014657	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756014658	dimerization interface [polypeptide binding]; other site
164756014659	putative DNA binding site [nucleotide binding]; other site
164756014660	putative Zn2+ binding site [ion binding]; other site
164756014661	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
164756014662	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
164756014663	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
164756014664	Part of AAA domain; Region: AAA_19; pfam13245
164756014665	Family description; Region: UvrD_C_2; pfam13538
164756014666	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
164756014667	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
164756014668	active site
164756014669	FMN binding site [chemical binding]; other site
164756014670	substrate binding site [chemical binding]; other site
164756014671	3Fe-4S cluster binding site [ion binding]; other site
164756014672	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
164756014673	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
164756014674	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
164756014675	metal binding site [ion binding]; metal-binding site
164756014676	active site
164756014677	I-site; other site
164756014678	hypothetical protein; Provisional; Region: PRK06547
164756014679	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
164756014680	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
164756014681	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
164756014682	Walker A/P-loop; other site
164756014683	ATP binding site [chemical binding]; other site
164756014684	Q-loop/lid; other site
164756014685	ABC transporter signature motif; other site
164756014686	Walker B; other site
164756014687	D-loop; other site
164756014688	H-loop/switch region; other site
164756014689	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
164756014690	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
164756014691	Walker A/P-loop; other site
164756014692	ATP binding site [chemical binding]; other site
164756014693	Q-loop/lid; other site
164756014694	ABC transporter signature motif; other site
164756014695	Walker B; other site
164756014696	D-loop; other site
164756014697	H-loop/switch region; other site
164756014698	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
164756014699	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756014700	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
164756014701	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
164756014702	active site
164756014703	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
164756014704	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
164756014705	active site
164756014706	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756014707	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756014708	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756014709	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756014710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
164756014711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
164756014712	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
164756014713	dimerization interface [polypeptide binding]; other site
164756014714	Cobalt transport protein; Region: CbiQ; cl00463
164756014715	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
164756014716	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
164756014717	Walker A/P-loop; other site
164756014718	ATP binding site [chemical binding]; other site
164756014719	Q-loop/lid; other site
164756014720	ABC transporter signature motif; other site
164756014721	Walker B; other site
164756014722	D-loop; other site
164756014723	H-loop/switch region; other site
164756014724	BioY family; Region: BioY; pfam02632
164756014725	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
164756014726	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
164756014727	active site
164756014728	catalytic site [active]
164756014729	Zn binding site [ion binding]; other site
164756014730	tetramer interface [polypeptide binding]; other site
164756014731	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
164756014732	agmatinase; Region: agmatinase; TIGR01230
164756014733	oligomer interface [polypeptide binding]; other site
164756014734	putative active site [active]
164756014735	Mn binding site [ion binding]; other site
164756014736	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
164756014737	classical (c) SDRs; Region: SDR_c; cd05233
164756014738	NAD(P) binding site [chemical binding]; other site
164756014739	active site
164756014740	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
164756014741	classical (c) SDRs; Region: SDR_c; cd05233
164756014742	NAD(P) binding site [chemical binding]; other site
164756014743	active site
164756014744	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
164756014745	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
164756014746	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
164756014747	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
164756014748	Ferredoxin [Energy production and conversion]; Region: COG1146
164756014749	4Fe-4S binding domain; Region: Fer4; pfam00037
164756014750	Predicted transcriptional regulator [Transcription]; Region: COG2345
164756014751	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
164756014752	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
164756014753	heme-binding site [chemical binding]; other site
164756014754	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
164756014755	Amidase; Region: Amidase; cl11426
164756014756	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
164756014757	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756014758	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
164756014759	YCII-related domain; Region: YCII; cl00999
164756014760	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
164756014761	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
164756014762	putative active site [active]
164756014763	putative FMN binding site [chemical binding]; other site
164756014764	putative substrate binding site [chemical binding]; other site
164756014765	putative catalytic residue [active]
164756014766	FAD binding domain; Region: FAD_binding_3; pfam01494
164756014767	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756014768	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
164756014769	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756014770	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756014771	ABC transporter; Region: ABC_tran_2; pfam12848
164756014772	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
164756014773	Cutinase; Region: Cutinase; pfam01083
164756014774	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
164756014775	Pirin-related protein [General function prediction only]; Region: COG1741
164756014776	Pirin; Region: Pirin; pfam02678
164756014777	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
164756014778	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
164756014779	classical (c) SDRs; Region: SDR_c; cd05233
164756014780	NAD(P) binding site [chemical binding]; other site
164756014781	active site
164756014782	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
164756014783	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
164756014784	MOSC domain; Region: MOSC; pfam03473
164756014785	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756014786	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014788	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756014789	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
164756014790	active site
164756014791	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
164756014792	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
164756014793	catalytic residues [active]
164756014794	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
164756014795	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756014796	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756014797	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
164756014798	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
164756014799	active site residue [active]
164756014800	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
164756014801	active site residue [active]
164756014802	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
164756014803	active site residue [active]
164756014804	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
164756014805	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
164756014806	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
164756014807	putative homodimer interface [polypeptide binding]; other site
164756014808	putative homotetramer interface [polypeptide binding]; other site
164756014809	putative allosteric switch controlling residues; other site
164756014810	putative metal binding site [ion binding]; other site
164756014811	putative homodimer-homodimer interface [polypeptide binding]; other site
164756014812	Predicted membrane protein [Function unknown]; Region: COG2149
164756014813	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
164756014814	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
164756014815	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756014816	motif II; other site
164756014817	Domain of unknown function (DUF305); Region: DUF305; pfam03713
164756014818	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
164756014819	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
164756014820	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
164756014821	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
164756014822	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
164756014823	active site
164756014824	catalytic tetrad [active]
164756014825	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756014826	MarR family; Region: MarR_2; pfam12802
164756014827	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
164756014828	active site
164756014829	catalytic site [active]
164756014830	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
164756014831	active site
164756014832	catalytic site [active]
164756014833	EVE domain; Region: EVE; cl00728
164756014834	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
164756014835	Transcriptional regulators [Transcription]; Region: FadR; COG2186
164756014836	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756014837	DNA-binding site [nucleotide binding]; DNA binding site
164756014838	FCD domain; Region: FCD; pfam07729
164756014839	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
164756014840	AAA domain; Region: AAA_33; pfam13671
164756014841	ATP-binding site [chemical binding]; other site
164756014842	Gluconate-6-phosphate binding site [chemical binding]; other site
164756014843	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
164756014844	fructuronate transporter; Provisional; Region: PRK10034; cl15264
164756014845	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
164756014846	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
164756014847	active site
164756014848	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
164756014849	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
164756014850	putative NAD(P) binding site [chemical binding]; other site
164756014851	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
164756014852	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
164756014853	dimer interface [polypeptide binding]; other site
164756014854	acyl-activating enzyme (AAE) consensus motif; other site
164756014855	putative active site [active]
164756014856	AMP binding site [chemical binding]; other site
164756014857	putative CoA binding site [chemical binding]; other site
164756014858	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
164756014859	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
164756014860	active site
164756014861	FMN binding site [chemical binding]; other site
164756014862	substrate binding site [chemical binding]; other site
164756014863	3Fe-4S cluster binding site [ion binding]; other site
164756014864	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
164756014865	nucleophilic elbow; other site
164756014866	catalytic triad; other site
164756014867	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
164756014868	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
164756014869	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
164756014870	putative acyl-acceptor binding pocket; other site
164756014871	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014872	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014873	short chain dehydrogenase; Provisional; Region: PRK06523
164756014874	classical (c) SDRs; Region: SDR_c; cd05233
164756014875	NAD(P) binding site [chemical binding]; other site
164756014876	active site
164756014877	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
164756014878	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
164756014879	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
164756014880	DNA binding residues [nucleotide binding]
164756014881	dimer interface [polypeptide binding]; other site
164756014882	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
164756014883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
164756014884	Mg2+ binding site [ion binding]; other site
164756014885	G-X-G motif; other site
164756014886	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
164756014887	ATP binding site [chemical binding]; other site
164756014888	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
164756014889	active site
164756014890	metal binding site [ion binding]; metal-binding site
164756014891	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
164756014892	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
164756014893	CAP-like domain; other site
164756014894	DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521
164756014895	active site
164756014896	primary dimer interface [polypeptide binding]; other site
164756014897	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
164756014898	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
164756014899	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
164756014900	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
164756014901	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
164756014902	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
164756014903	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
164756014904	NAD binding site [chemical binding]; other site
164756014905	ligand binding site [chemical binding]; other site
164756014906	catalytic site [active]
164756014907	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
164756014908	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
164756014909	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756014910	FAD binding domain; Region: FAD_binding_3; pfam01494
164756014911	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
164756014912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756014913	dimer interface [polypeptide binding]; other site
164756014914	conserved gate region; other site
164756014915	putative PBP binding loops; other site
164756014916	ABC-ATPase subunit interface; other site
164756014917	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
164756014918	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
164756014919	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
164756014920	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
164756014921	Walker A/P-loop; other site
164756014922	ATP binding site [chemical binding]; other site
164756014923	Q-loop/lid; other site
164756014924	ABC transporter signature motif; other site
164756014925	Walker B; other site
164756014926	D-loop; other site
164756014927	H-loop/switch region; other site
164756014928	NMT1-like family; Region: NMT1_2; pfam13379
164756014929	NMT1/THI5 like; Region: NMT1; pfam09084
164756014930	membrane-bound complex binding site; other site
164756014931	hinge residues; other site
164756014932	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756014933	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756014934	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
164756014935	active site
164756014936	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
164756014937	putative hydrophobic ligand binding site [chemical binding]; other site
164756014938	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
164756014939	dimerization interface [polypeptide binding]; other site
164756014940	putative DNA binding site [nucleotide binding]; other site
164756014941	putative Zn2+ binding site [ion binding]; other site
164756014942	Beta-lactamase; Region: Beta-lactamase; pfam00144
164756014943	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
164756014944	PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023
164756014945	Domain of unknown function (DUF222); Region: DUF222; pfam02720
164756014946	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756014947	MULE transposase domain; Region: MULE; pfam10551
164756014948	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
164756014949	active site
164756014950	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
164756014951	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
164756014952	Walker A motif; other site
164756014953	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
164756014954	Hom_end-associated Hint; Region: Hom_end_hint; pfam05203
164756014955	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
164756014956	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
164756014957	Walker A motif; other site
164756014958	ATP binding site [chemical binding]; other site
164756014959	Walker B motif; other site
164756014960	DNA binding loops [nucleotide binding]
164756014961	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
164756014962	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
164756014963	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
164756014964	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
164756014965	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
164756014966	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
164756014967	dimer interface [polypeptide binding]; other site
164756014968	ssDNA binding site [nucleotide binding]; other site
164756014969	tetramer (dimer of dimers) interface [polypeptide binding]; other site
164756014970	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
164756014971	Predicted integral membrane protein [Function unknown]; Region: COG5650
164756014972	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
164756014973	Transglycosylase; Region: Transgly; pfam00912
164756014974	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
164756014975	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
164756014976	Predicted transcriptional regulators [Transcription]; Region: COG1695
164756014977	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
164756014978	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
164756014979	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
164756014980	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756014981	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
164756014982	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
164756014983	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
164756014984	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
164756014985	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
164756014986	Transcriptional regulators [Transcription]; Region: GntR; COG1802
164756014987	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
164756014988	DNA-binding site [nucleotide binding]; DNA binding site
164756014989	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
164756014990	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
164756014991	substrate binding pocket [chemical binding]; other site
164756014992	membrane-bound complex binding site; other site
164756014993	hinge residues; other site
164756014994	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
164756014995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
164756014996	dimer interface [polypeptide binding]; other site
164756014997	conserved gate region; other site
164756014998	putative PBP binding loops; other site
164756014999	ABC-ATPase subunit interface; other site
164756015000	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
164756015001	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
164756015002	Walker A/P-loop; other site
164756015003	ATP binding site [chemical binding]; other site
164756015004	Q-loop/lid; other site
164756015005	ABC transporter signature motif; other site
164756015006	Walker B; other site
164756015007	D-loop; other site
164756015008	H-loop/switch region; other site
164756015009	MarR family; Region: MarR; pfam01047
164756015010	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
164756015011	short chain dehydrogenase; Provisional; Region: PRK08219
164756015012	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
164756015013	NAD(P) binding site [chemical binding]; other site
164756015014	active site
164756015015	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
164756015016	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
164756015017	putative active site [active]
164756015018	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
164756015019	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
164756015020	HIGH motif; other site
164756015021	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
164756015022	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
164756015023	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
164756015024	active site
164756015025	KMSKS motif; other site
164756015026	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
164756015027	tRNA binding surface [nucleotide binding]; other site
164756015028	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
164756015029	hypothetical protein; Validated; Region: PRK00228
164756015030	H+ Antiporter protein; Region: 2A0121; TIGR00900
164756015031	TIGR03084 family protein; Region: TIGR03084
164756015032	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
164756015033	Wyosine base formation; Region: Wyosine_form; pfam08608
164756015034	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756015035	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756015036	active site
164756015037	ATP binding site [chemical binding]; other site
164756015038	substrate binding site [chemical binding]; other site
164756015039	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
164756015040	substrate binding site [chemical binding]; other site
164756015041	activation loop (A-loop); other site
164756015042	activation loop (A-loop); other site
164756015043	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
164756015044	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
164756015045	active site
164756015046	NTP binding site [chemical binding]; other site
164756015047	metal binding triad [ion binding]; metal-binding site
164756015048	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
164756015049	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
164756015050	Zn2+ binding site [ion binding]; other site
164756015051	Mg2+ binding site [ion binding]; other site
164756015052	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
164756015053	active site
164756015054	Ap6A binding site [chemical binding]; other site
164756015055	nudix motif; other site
164756015056	metal binding site [ion binding]; metal-binding site
164756015057	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
164756015058	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
164756015059	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
164756015060	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
164756015061	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
164756015062	DNA binding residues [nucleotide binding]
164756015063	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
164756015064	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
164756015065	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
164756015066	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
164756015067	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
164756015068	catalytic residues [active]
164756015069	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
164756015070	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
164756015071	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
164756015072	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
164756015073	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
164756015074	active site
164756015075	metal binding site [ion binding]; metal-binding site
164756015076	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
164756015077	ParB-like nuclease domain; Region: ParBc; pfam02195
164756015078	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
164756015079	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
164756015080	P-loop; other site
164756015081	Magnesium ion binding site [ion binding]; other site
164756015082	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
164756015083	Magnesium ion binding site [ion binding]; other site
164756015084	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
164756015085	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
164756015086	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
164756015087	G-X-X-G motif; other site
164756015088	R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297
164756015089	RxxxH motif; other site
164756015090	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
164756015091	hypothetical protein; Validated; Region: PRK00041
164756015092	ribonuclease P; Reviewed; Region: rnpA; PRK00588
164756015093	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
164756015094	Protein of unknown function (DUF615); Region: DUF615; cl01147
164756015095	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
164756015096	beta-clamp/clamp loader binding surface; other site
164756015097	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
164756015098	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
164756015099	TPP-binding site [chemical binding]; other site
164756015100	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
164756015101	Integrase core domain; Region: rve_3; pfam13683
164756015102	Helix-turn-helix domain; Region: HTH_38; pfam13936
164756015103	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
164756015104	Integrase core domain; Region: rve; pfam00665
164756015105	HTH-like domain; Region: HTH_21; pfam13276
164756015106	Integrase core domain; Region: rve; pfam00665
164756015107	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
164756015108	Transposase; Region: HTH_Tnp_1; cl17663
164756015109	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756015110	MULE transposase domain; Region: MULE; pfam10551
164756015111	Integrase core domain; Region: rve_3; cl15866
164756015112	Transcriptional regulator [Transcription]; Region: IclR; COG1414
164756015113	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
164756015114	Bacterial transcriptional regulator; Region: IclR; pfam01614
164756015115	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
164756015116	acetaldehyde dehydrogenase; Validated; Region: PRK08300
164756015117	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
164756015118	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
164756015119	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
164756015120	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
164756015121	active site
164756015122	catalytic residues [active]
164756015123	metal binding site [ion binding]; metal-binding site
164756015124	DmpG-like communication domain; Region: DmpG_comm; pfam07836
164756015125	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
164756015126	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
164756015127	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756015128	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756015129	iron-sulfur cluster [ion binding]; other site
164756015130	[2Fe-2S] cluster binding site [ion binding]; other site
164756015131	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756015132	beta subunit interface [polypeptide binding]; other site
164756015133	alpha subunit interface [polypeptide binding]; other site
164756015134	active site
164756015135	substrate binding site [chemical binding]; other site
164756015136	Fe binding site [ion binding]; other site
164756015137	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756015138	inter-subunit interface; other site
164756015139	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
164756015140	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
164756015141	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
164756015142	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
164756015143	active site
164756015144	metal binding site [ion binding]; metal-binding site
164756015145	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
164756015146	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
164756015147	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
164756015148	MarR family; Region: MarR; pfam01047
164756015149	MarR family; Region: MarR_2; cl17246
164756015150	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
164756015151	Cupin domain; Region: Cupin_2; pfam07883
164756015152	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756015153	inter-subunit interface; other site
164756015154	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
164756015155	iron-sulfur cluster [ion binding]; other site
164756015156	[2Fe-2S] cluster binding site [ion binding]; other site
164756015157	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756015158	beta subunit interface [polypeptide binding]; other site
164756015159	alpha subunit interface [polypeptide binding]; other site
164756015160	active site
164756015161	substrate binding site [chemical binding]; other site
164756015162	Fe binding site [ion binding]; other site
164756015163	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
164756015164	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
164756015165	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
164756015166	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
164756015167	DUF35 OB-fold domain; Region: DUF35; pfam01796
164756015168	lipid-transfer protein; Provisional; Region: PRK07855
164756015169	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
164756015170	active site
164756015171	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
164756015172	CoA-transferase family III; Region: CoA_transf_3; pfam02515
164756015173	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
164756015174	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
164756015175	putative NAD(P) binding site [chemical binding]; other site
164756015176	catalytic Zn binding site [ion binding]; other site
164756015177	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
164756015178	inter-subunit interface; other site
164756015179	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
164756015180	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
164756015181	alpha subunit interaction site [polypeptide binding]; other site
164756015182	beta subunit interaction site [polypeptide binding]; other site
164756015183	iron-sulfur cluster [ion binding]; other site
164756015184	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
164756015185	beta subunit interface [polypeptide binding]; other site
164756015186	alpha subunit interface [polypeptide binding]; other site
164756015187	active site
164756015188	substrate binding site [chemical binding]; other site
164756015189	Fe binding site [ion binding]; other site
164756015190	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756015191	MULE transposase domain; Region: MULE; pfam10551
164756015192	MarR family; Region: MarR; pfam01047
164756015193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756015194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
164756015195	replicative DNA helicase; Region: DnaB; TIGR00665
164756015196	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
164756015197	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
164756015198	Walker A motif; other site
164756015199	ATP binding site [chemical binding]; other site
164756015200	Walker B motif; other site
164756015201	DNA binding loops [nucleotide binding]
164756015202	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
164756015203	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
164756015204	Transcription factor WhiB; Region: Whib; pfam02467
164756015205	Transcription factor WhiB; Region: Whib; pfam02467
164756015206	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
164756015207	non-specific DNA binding site [nucleotide binding]; other site
164756015208	salt bridge; other site
164756015209	sequence-specific DNA binding site [nucleotide binding]; other site
164756015210	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
164756015211	active site
164756015212	catalytic site [active]
164756015213	substrate binding site [chemical binding]; other site
164756015214	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
164756015215	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
164756015216	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
164756015217	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
164756015218	active site
164756015219	Fe-S cluster binding site [ion binding]; other site
164756015220	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
164756015221	Protein of unknown function (DUF499); Region: DUF499; pfam04465
164756015222	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
164756015223	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
164756015224	DEAD-like helicases superfamily; Region: DEXDc; smart00487
164756015225	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
164756015226	ATP binding site [chemical binding]; other site
164756015227	putative Mg++ binding site [ion binding]; other site
164756015228	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
164756015229	nucleotide binding region [chemical binding]; other site
164756015230	ATP-binding site [chemical binding]; other site
164756015231	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
164756015232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
164756015233	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
164756015234	putative active site [active]
164756015235	Helix-turn-helix domain; Region: HTH_38; pfam13936
164756015236	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
164756015237	Integrase core domain; Region: rve; pfam00665
164756015238	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
164756015239	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
164756015240	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
164756015241	motif II; other site
164756015242	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
164756015243	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756015244	MULE transposase domain; Region: MULE; pfam10551
164756015245	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
164756015246	Catalytic domain of Protein Kinases; Region: PKc; cd00180
164756015247	active site
164756015248	ATP binding site [chemical binding]; other site
164756015249	substrate binding site [chemical binding]; other site
164756015250	activation loop (A-loop); other site
164756015251	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
164756015252	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
164756015253	active site
164756015254	DNA binding site [nucleotide binding]
164756015255	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
164756015256	DNA binding site [nucleotide binding]
164756015257	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
164756015258	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
164756015259	putative active site [active]
164756015260	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
164756015261	HerA helicase [Replication, recombination, and repair]; Region: COG0433
164756015262	Cutinase; Region: Cutinase; pfam01083
164756015263	AAA-like domain; Region: AAA_10; pfam12846
164756015264	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cd01120
164756015265	Walker A motif; other site
164756015266	ATP binding site [chemical binding]; other site
164756015267	Walker B motif; other site
164756015268	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
164756015269	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
164756015270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756015271	Walker A motif; other site
164756015272	ATP binding site [chemical binding]; other site
164756015273	Walker B motif; other site
164756015274	arginine finger; other site
164756015275	Protein of unknown function (DUF690); Region: DUF690; cl04939
164756015276	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
164756015277	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756015278	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
164756015279	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756015280	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
164756015281	PPE family; Region: PPE; pfam00823
164756015282	Proteins of 100 residues with WXG; Region: WXG100; cl02005
164756015283	Proteins of 100 residues with WXG; Region: WXG100; cl02005
164756015284	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
164756015285	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
164756015286	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
164756015287	active site
164756015288	catalytic residues [active]
164756015289	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
164756015290	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
164756015291	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
164756015292	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
164756015293	P-loop; other site
164756015294	Magnesium ion binding site [ion binding]; other site
164756015295	EspG family; Region: ESX-1_EspG; pfam14011
164756015296	ParB-like nuclease domain; Region: ParB; smart00470
164756015297	Helix-turn-helix domain; Region: HTH_38; pfam13936
164756015298	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
164756015299	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
164756015300	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
164756015301	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
164756015302	catalytic residues [active]
164756015303	catalytic nucleophile [active]
164756015304	Recombinase; Region: Recombinase; pfam07508
164756015305	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756015306	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
164756015307	Walker A motif; other site
164756015308	ATP binding site [chemical binding]; other site
164756015309	Walker B motif; other site
164756015310	arginine finger; other site
164756015311	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
164756015312	active site
164756015313	catalytic triad [active]
164756015314	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756015315	Walker B; other site
164756015316	D-loop; other site
164756015317	H-loop/switch region; other site
164756015318	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756015319	MULE transposase domain; Region: MULE; pfam10551
164756015320	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
164756015321	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
164756015322	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
164756015323	active site
164756015324	DNA binding site [nucleotide binding]
164756015325	Int/Topo IB signature motif; other site
164756015326	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
164756015327	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
164756015328	active site
164756015329	DNA binding site [nucleotide binding]
164756015330	Int/Topo IB signature motif; other site
164756015331	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756015332	putative transposase OrfB; Reviewed; Region: PHA02517
164756015333	HTH-like domain; Region: HTH_21; pfam13276
164756015334	Integrase core domain; Region: rve; pfam00665
164756015335	Integrase core domain; Region: rve_3; cl15866
164756015336	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756015337	MULE transposase domain; Region: MULE; pfam10551
164756015338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
164756015339	AAA domain; Region: AAA_23; pfam13476
164756015340	Walker A/P-loop; other site
164756015341	ATP binding site [chemical binding]; other site
164756015342	putative transposase OrfB; Reviewed; Region: PHA02517
164756015343	HTH-like domain; Region: HTH_21; pfam13276
164756015344	Integrase core domain; Region: rve; pfam00665
164756015345	Integrase core domain; Region: rve_3; cl15866
164756015346	putative transposase OrfB; Reviewed; Region: PHA02517
164756015347	Integrase core domain; Region: rve; pfam00665
164756015348	Transposase; Region: HTH_Tnp_1; cl17663
164756015349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
164756015350	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
164756015351	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
164756015352	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
164756015353	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
164756015354	nudix motif; other site
164756015355	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
164756015356	Zn2+ binding site [ion binding]; other site
164756015357	Mg2+ binding site [ion binding]; other site
164756015358	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
164756015359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
164756015360	Transport protein; Region: actII; TIGR00833
164756015361	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
164756015362	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
164756015363	Transposase; Region: HTH_Tnp_1; cl17663
164756015364	HTH-like domain; Region: HTH_21; pfam13276
164756015365	Integrase core domain; Region: rve; pfam00665
164756015366	Helix-turn-helix domain; Region: HTH_38; pfam13936
164756015367	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
164756015368	Integrase core domain; Region: rve; pfam00665
164756015369	Integrase core domain; Region: rve_3; pfam13683
164756015370	putative transposase OrfB; Reviewed; Region: PHA02517
164756015371	HTH-like domain; Region: HTH_21; pfam13276
164756015372	Integrase core domain; Region: rve; pfam00665
164756015373	Integrase core domain; Region: rve_3; pfam13683
164756015374	Transposase, Mutator family; Region: Transposase_mut; pfam00872
164756015375	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
164756015376	DNA binding residues [nucleotide binding]
164756015377	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
164756015378	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
164756015379	Active Sites [active]
164756015380	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
164756015381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
164756015382	Walker A motif; other site
164756015383	ATP binding site [chemical binding]; other site
164756015384	Walker B motif; other site
164756015385	arginine finger; other site
164756015386	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
164756015387	VWA-like domain (DUF2201); Region: DUF2201; pfam09967
164756015388	AAA domain; Region: AAA_30; pfam13604
164756015389	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
164756015390	AAA domain; Region: AAA_12; pfam13087
164756015391	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830