-- dump date 20120504_153014 -- class Genbank::misc_feature -- table misc_feature_note -- id note 278137000001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137000002 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137000003 active site 278137000004 DNA binding site [nucleotide binding] 278137000005 Int/Topo IB signature motif; other site 278137000006 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278137000007 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 278137000008 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137000009 Magnesium ion binding site [ion binding]; other site 278137000010 Transcription factor WhiB; Region: Whib; pfam02467 278137000011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137000012 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 278137000013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137000014 S-adenosylmethionine binding site [chemical binding]; other site 278137000015 Phospholipid methyltransferase; Region: PEMT; cl00763 278137000016 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 278137000017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137000018 S-adenosylmethionine binding site [chemical binding]; other site 278137000019 cyclase homology domain; Region: CHD; cd07302 278137000020 nucleotidyl binding site; other site 278137000021 metal binding site [ion binding]; metal-binding site 278137000022 dimer interface [polypeptide binding]; other site 278137000023 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 278137000024 Phospholipid methyltransferase; Region: PEMT; cl00763 278137000025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137000026 dimerization interface [polypeptide binding]; other site 278137000027 putative DNA binding site [nucleotide binding]; other site 278137000028 putative Zn2+ binding site [ion binding]; other site 278137000029 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 278137000030 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137000031 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137000032 Low molecular weight phosphatase family; Region: LMWPc; cl00105 278137000033 active site 278137000034 Low molecular weight phosphatase family; Region: LMWPc; cd00115 278137000035 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 278137000036 active site 278137000037 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 278137000038 Membrane transport protein; Region: Mem_trans; cl09117 278137000039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137000040 dimerization interface [polypeptide binding]; other site 278137000041 putative DNA binding site [nucleotide binding]; other site 278137000042 putative Zn2+ binding site [ion binding]; other site 278137000043 DinB superfamily; Region: DinB_2; pfam12867 278137000044 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 278137000045 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137000046 putative metal binding site [ion binding]; other site 278137000047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137000048 dimerization interface [polypeptide binding]; other site 278137000049 putative DNA binding site [nucleotide binding]; other site 278137000050 putative Zn2+ binding site [ion binding]; other site 278137000051 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 278137000052 active site 278137000053 catalytic residues [active] 278137000054 DNA binding site [nucleotide binding] 278137000055 Int/Topo IB signature motif; other site 278137000056 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 278137000057 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278137000058 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 278137000059 active site 278137000060 catalytic residues [active] 278137000061 DNA binding site [nucleotide binding] 278137000062 Int/Topo IB signature motif; other site 278137000063 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278137000064 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 278137000065 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 278137000066 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 278137000067 NlpC/P60 family; Region: NLPC_P60; cl11438 278137000068 Helix-turn-helix domains; Region: HTH; cl00088 278137000069 Peptidase family M48; Region: Peptidase_M48; cl12018 278137000070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 278137000071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137000072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137000073 DNA binding site [nucleotide binding] 278137000074 NlpC/P60 family; Region: NLPC_P60; cl11438 278137000075 Bacterial Ig-like domain; Region: Big_5; cl01012 278137000076 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137000077 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 278137000078 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 278137000079 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 278137000080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137000081 Mg2+ binding site [ion binding]; other site 278137000082 G-X-G motif; other site 278137000083 Integrase core domain; Region: rve_3; cl15866 278137000084 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278137000085 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 278137000086 active site 278137000087 catalytic residues [active] 278137000088 DNA binding site [nucleotide binding] 278137000089 Int/Topo IB signature motif; other site 278137000090 Transposase domain (DUF772); Region: DUF772; pfam05598 278137000091 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137000092 DDE superfamily endonuclease; Region: DDE_4; cl15789 278137000093 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278137000094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137000095 active site 278137000096 DNA binding site [nucleotide binding] 278137000097 Int/Topo IB signature motif; other site 278137000098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137000099 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137000100 active site 278137000101 Int/Topo IB signature motif; other site 278137000102 DNA binding site [nucleotide binding] 278137000103 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 278137000104 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278137000105 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137000106 active site 278137000107 DNA binding site [nucleotide binding] 278137000108 Int/Topo IB signature motif; other site 278137000109 Peptidase family M48; Region: Peptidase_M48; cl12018 278137000110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 278137000111 Integrase core domain; Region: rve; cl01316 278137000112 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 278137000113 Helix-turn-helix domains; Region: HTH; cl00088 278137000114 Winged helix-turn helix; Region: HTH_29; pfam13551 278137000115 Helix-turn-helix domains; Region: HTH; cl00088 278137000116 Integrase core domain; Region: rve; cl01316 278137000117 Integrase core domain; Region: rve_3; cl15866 278137000118 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 278137000119 Helix-turn-helix domains; Region: HTH; cl00088 278137000120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 278137000121 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137000122 cyclase homology domain; Region: CHD; cd07302 278137000123 metal binding site [ion binding]; metal-binding site 278137000124 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 278137000125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 278137000126 Bacterial Ig-like domain; Region: Big_5; cl01012 278137000127 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137000128 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 278137000129 NlpC/P60 family; Region: NLPC_P60; cl11438 278137000130 NlpC/P60 family; Region: NLPC_P60; cl11438 278137000131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137000132 Domain of unknown function (DUF305); Region: DUF305; cl15795 278137000133 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137000134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137000135 dimer interface [polypeptide binding]; other site 278137000136 phosphorylation site [posttranslational modification] 278137000137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137000138 ATP binding site [chemical binding]; other site 278137000139 Mg2+ binding site [ion binding]; other site 278137000140 G-X-G motif; other site 278137000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137000142 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 278137000143 active site 278137000144 phosphorylation site [posttranslational modification] 278137000145 intermolecular recognition site; other site 278137000146 dimerization interface [polypeptide binding]; other site 278137000147 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137000148 DNA binding site [nucleotide binding] 278137000149 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 278137000150 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137000151 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137000152 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137000153 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 278137000154 NlpC/P60 family; Region: NLPC_P60; cl11438 278137000155 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 278137000156 catalytic residues [active] 278137000157 Helix-turn-helix domains; Region: HTH; cl00088 278137000158 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137000159 Helix-turn-helix domains; Region: HTH; cl00088 278137000160 Peptidase family M48; Region: Peptidase_M48; cl12018 278137000161 Predicted esterase [General function prediction only]; Region: COG0627 278137000162 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137000163 Peptidase family M23; Region: Peptidase_M23; pfam01551 278137000164 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 278137000165 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 278137000166 putative active site [active] 278137000167 catalytic triad [active] 278137000168 putative dimer interface [polypeptide binding]; other site 278137000169 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137000170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137000171 active site 278137000172 phosphorylation site [posttranslational modification] 278137000173 intermolecular recognition site; other site 278137000174 dimerization interface [polypeptide binding]; other site 278137000175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137000176 DNA binding site [nucleotide binding] 278137000177 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278137000178 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 278137000179 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 278137000180 NodB motif; other site 278137000181 active site 278137000182 catalytic site [active] 278137000183 metal binding site [ion binding]; metal-binding site 278137000184 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 278137000185 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 278137000186 dimer interface [polypeptide binding]; other site 278137000187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137000188 catalytic residue [active] 278137000189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137000190 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278137000191 active site residue [active] 278137000192 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 278137000193 dimerization interface [polypeptide binding]; other site 278137000194 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 278137000195 putative homodimer interface [polypeptide binding]; other site 278137000196 putative homotetramer interface [polypeptide binding]; other site 278137000197 putative allosteric switch controlling residues; other site 278137000198 putative metal binding site [ion binding]; other site 278137000199 putative homodimer-homodimer interface [polypeptide binding]; other site 278137000200 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 278137000201 Domain of unknown function (DUF305); Region: DUF305; cl15795 278137000202 Domain of unknown function (DUF305); Region: DUF305; cl15795 278137000203 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 278137000204 Short C-terminal domain; Region: SHOCT; cl01373 278137000205 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 278137000206 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 278137000207 active site residue [active] 278137000208 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 278137000209 active site residue [active] 278137000210 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 278137000211 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137000212 Predicted integral membrane protein [Function unknown]; Region: COG0392 278137000213 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 278137000214 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 278137000215 metal-binding site [ion binding] 278137000216 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 278137000217 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137000218 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137000219 putative phosphoketolase; Provisional; Region: PRK05261 278137000220 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 278137000221 TPP-binding site; other site 278137000222 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 278137000223 XFP C-terminal domain; Region: XFP_C; pfam09363 278137000224 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 278137000225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137000226 S-adenosylmethionine binding site [chemical binding]; other site 278137000227 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 278137000228 active site 278137000229 catalytic triad [active] 278137000230 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 278137000231 putative active site [active] 278137000232 putative CoA binding site [chemical binding]; other site 278137000233 nudix motif; other site 278137000234 metal binding site [ion binding]; metal-binding site 278137000235 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 278137000236 Short C-terminal domain; Region: SHOCT; cl01373 278137000237 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 278137000238 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137000239 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137000240 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137000241 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 278137000242 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 278137000243 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 278137000244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137000245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 278137000246 Helix-turn-helix domains; Region: HTH; cl00088 278137000247 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 278137000248 active site residue [active] 278137000249 TrwC relaxase; Region: TrwC; pfam08751 278137000250 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 278137000251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137000252 Family description; Region: UvrD_C_2; cl15862 278137000253 putative transposase OrfB; Reviewed; Region: PHA02517 278137000254 HTH-like domain; Region: HTH_21; pfam13276 278137000255 Integrase core domain; Region: rve; cl01316 278137000256 Integrase core domain; Region: rve_3; cl15866 278137000257 Helix-turn-helix domains; Region: HTH; cl00088 278137000258 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137000259 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137000260 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 278137000261 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137000262 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137000263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137000264 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137000265 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137000266 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 278137000267 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 278137000268 catalytic residues [active] 278137000269 ParB-like nuclease domain; Region: ParBc; cl02129 278137000270 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 278137000271 DNA-binding interface [nucleotide binding]; DNA binding site 278137000272 Domain of unknown function (DUF932); Region: DUF932; cl12129 278137000273 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 278137000274 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 278137000275 active site 278137000276 DNA binding site [nucleotide binding] 278137000277 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 278137000278 DNA binding site [nucleotide binding] 278137000279 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137000280 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137000281 active site 278137000282 ATP binding site [chemical binding]; other site 278137000283 substrate binding site [chemical binding]; other site 278137000284 activation loop (A-loop); other site 278137000285 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 278137000286 putative active site [active] 278137000287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137000288 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 278137000289 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 278137000290 Helix-turn-helix domains; Region: HTH; cl00088 278137000291 cyclase homology domain; Region: CHD; cd07302 278137000292 nucleotidyl binding site; other site 278137000293 metal binding site [ion binding]; metal-binding site 278137000294 dimer interface [polypeptide binding]; other site 278137000295 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 278137000296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137000297 S-adenosylmethionine binding site [chemical binding]; other site 278137000298 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 278137000299 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 278137000300 putative homotetramer interface [polypeptide binding]; other site 278137000301 putative homodimer interface [polypeptide binding]; other site 278137000302 putative allosteric switch controlling residues; other site 278137000303 putative metal binding site [ion binding]; other site 278137000304 putative homodimer-homodimer interface [polypeptide binding]; other site 278137000305 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 278137000306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137000307 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278137000308 active site residue [active] 278137000309 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137000310 dimerization interface [polypeptide binding]; other site 278137000311 putative DNA binding site [nucleotide binding]; other site 278137000312 putative Zn2+ binding site [ion binding]; other site 278137000313 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 278137000314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137000315 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137000316 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 278137000317 Cadmium resistance transporter; Region: Cad; pfam03596 278137000318 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 278137000319 catalytic residues [active] 278137000320 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 278137000321 dimer interface [polypeptide binding]; other site 278137000322 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 278137000323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137000324 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 278137000325 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 278137000326 dimer interface [polypeptide binding]; other site 278137000327 decamer (pentamer of dimers) interface [polypeptide binding]; other site 278137000328 catalytic triad [active] 278137000329 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 278137000330 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 278137000331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137000332 Family description; Region: UvrD_C_2; cl15862 278137000333 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137000334 metal binding site [ion binding]; metal-binding site 278137000335 active site 278137000336 I-site; other site 278137000337 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137000338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137000339 Helix-turn-helix domains; Region: HTH; cl00088 278137000340 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 278137000341 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 278137000342 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 278137000343 catalytic residues [active] 278137000344 catalytic nucleophile [active] 278137000345 Presynaptic Site I dimer interface [polypeptide binding]; other site 278137000346 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 278137000347 Synaptic Flat tetramer interface [polypeptide binding]; other site 278137000348 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 278137000349 DNA-binding interface [nucleotide binding]; DNA binding site 278137000350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137000351 non-specific DNA binding site [nucleotide binding]; other site 278137000352 salt bridge; other site 278137000353 sequence-specific DNA binding site [nucleotide binding]; other site 278137000354 Domain of unknown function (DUF955); Region: DUF955; cl01076 278137000355 Abi-like protein; Region: Abi_2; cl01988 278137000356 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 278137000357 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137000358 P-loop; other site 278137000359 Magnesium ion binding site [ion binding]; other site 278137000360 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 278137000361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137000362 Walker A motif; other site 278137000363 ATP binding site [chemical binding]; other site 278137000364 Walker B motif; other site 278137000365 arginine finger; other site 278137000366 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 278137000367 DnaA box-binding interface [nucleotide binding]; other site 278137000368 DNA polymerase III subunit beta; Validated; Region: PRK07761 278137000369 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 278137000370 putative DNA binding surface [nucleotide binding]; other site 278137000371 dimer interface [polypeptide binding]; other site 278137000372 beta-clamp/clamp loader binding surface; other site 278137000373 beta-clamp/translesion DNA polymerase binding surface; other site 278137000374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000375 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 278137000376 recombination protein F; Reviewed; Region: recF; PRK00064 278137000377 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 278137000378 Walker A/P-loop; other site 278137000379 ATP binding site [chemical binding]; other site 278137000380 Q-loop/lid; other site 278137000381 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137000382 ABC transporter signature motif; other site 278137000383 Walker B; other site 278137000384 D-loop; other site 278137000385 H-loop/switch region; other site 278137000386 Protein of unknown function (DUF721); Region: DUF721; cl02324 278137000387 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 278137000388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137000389 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 278137000390 anchoring element; other site 278137000391 dimer interface [polypeptide binding]; other site 278137000392 ATP binding site [chemical binding]; other site 278137000393 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 278137000394 active site 278137000395 putative metal-binding site [ion binding]; other site 278137000396 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 278137000397 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148 278137000398 CAP-like domain; other site 278137000399 active site 278137000400 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 278137000401 protein-splicing catalytic site; other site 278137000402 thioester formation/cholesterol transfer; other site 278137000403 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 278137000404 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 278137000405 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 278137000406 primary dimer interface [polypeptide binding]; other site 278137000407 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278137000408 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278137000409 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278137000410 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278137000411 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278137000412 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278137000413 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 278137000414 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 278137000415 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 278137000416 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 278137000417 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 278137000418 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 278137000419 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 278137000420 active site 278137000421 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 278137000422 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 278137000423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 278137000424 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 278137000425 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 278137000426 Glutamine amidotransferase class-I; Region: GATase; pfam00117 278137000427 glutamine binding [chemical binding]; other site 278137000428 catalytic triad [active] 278137000429 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137000430 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137000431 active site 278137000432 ATP binding site [chemical binding]; other site 278137000433 substrate binding site [chemical binding]; other site 278137000434 activation loop (A-loop); other site 278137000435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 278137000436 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278137000437 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278137000438 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278137000439 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278137000440 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137000441 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137000442 active site 278137000443 ATP binding site [chemical binding]; other site 278137000444 substrate binding site [chemical binding]; other site 278137000445 activation loop (A-loop); other site 278137000446 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 278137000447 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137000448 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 278137000449 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 278137000450 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 278137000451 active site 278137000452 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 278137000453 phosphopeptide binding site; other site 278137000454 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 278137000455 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 278137000456 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 278137000457 phosphopeptide binding site; other site 278137000458 Spore germination protein; Region: Spore_permease; cl15802 278137000459 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137000460 classical (c) SDRs; Region: SDR_c; cd05233 278137000461 NAD(P) binding site [chemical binding]; other site 278137000462 active site 278137000463 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137000464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000465 NAD(P) binding site [chemical binding]; other site 278137000466 active site 278137000467 Arginase family; Region: Arginase; cl00306 278137000468 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 278137000469 tetramer interface [polypeptide binding]; other site 278137000470 active site 278137000471 Zn binding site [ion binding]; other site 278137000472 catalytic site [active] 278137000473 Proteins of 100 residues with WXG; Region: WXG100; cl02005 278137000474 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 278137000475 ChaB; Region: ChaB; cl01887 278137000476 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 278137000477 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137000478 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 278137000479 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137000480 Pirin-related protein [General function prediction only]; Region: COG1741 278137000481 Cupin domain; Region: Cupin_2; cl09118 278137000482 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 278137000483 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137000484 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 278137000485 EVE domain; Region: EVE; cl00728 278137000486 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 278137000487 active site 278137000488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137000489 DivIVA domain; Region: DivI1A_domain; TIGR03544 278137000490 DivIVA domain; Region: DivI1A_domain; TIGR03544 278137000491 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137000492 MULE transposase domain; Region: MULE; pfam10551 278137000493 Uncharacterized conserved protein [Function unknown]; Region: COG3391 278137000494 Transcription factor WhiB; Region: Whib; pfam02467 278137000495 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 278137000496 EspG family; Region: ESX-1_EspG; pfam14011 278137000497 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 278137000498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137000499 Walker A motif; other site 278137000500 ATP binding site [chemical binding]; other site 278137000501 Walker B motif; other site 278137000502 arginine finger; other site 278137000503 Protein of unknown function (DUF690); Region: DUF690; cl04939 278137000504 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 278137000505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137000506 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 278137000507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137000508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137000509 PE family; Region: PE; pfam00934 278137000510 PPE family; Region: PPE; pfam00823 278137000511 Proteins of 100 residues with WXG; Region: WXG100; cl02005 278137000512 Proteins of 100 residues with WXG; Region: WXG100; cl02005 278137000513 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 278137000514 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137000515 P-loop; other site 278137000516 Magnesium ion binding site [ion binding]; other site 278137000517 Ubiquitin-like proteins; Region: UBQ; cl00155 278137000518 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 278137000519 PPE family; Region: PPE; pfam00823 278137000520 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 278137000521 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 278137000522 active site 278137000523 catalytic residues [active] 278137000524 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 278137000525 ThiC-associated domain; Region: ThiC-associated; pfam13667 278137000526 ThiC family; Region: ThiC; cl08031 278137000527 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 278137000528 dimerization domain swap beta strand [polypeptide binding]; other site 278137000529 regulatory protein interface [polypeptide binding]; other site 278137000530 active site 278137000531 regulatory phosphorylation site [posttranslational modification]; other site 278137000532 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 278137000533 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 278137000534 active site 278137000535 phosphorylation site [posttranslational modification] 278137000536 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 278137000537 active site 278137000538 P-loop; other site 278137000539 phosphorylation site [posttranslational modification] 278137000540 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278137000541 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 278137000542 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 278137000543 putative substrate binding site [chemical binding]; other site 278137000544 putative ATP binding site [chemical binding]; other site 278137000545 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 278137000546 Helix-turn-helix domains; Region: HTH; cl00088 278137000547 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137000548 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 278137000549 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 278137000550 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 278137000551 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137000552 Pirin-related protein [General function prediction only]; Region: COG1741 278137000553 Cupin domain; Region: Cupin_2; cl09118 278137000554 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 278137000555 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 278137000556 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 278137000557 Helix-turn-helix domains; Region: HTH; cl00088 278137000558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137000559 Helix-turn-helix domains; Region: HTH; cl00088 278137000560 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137000561 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 278137000562 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 278137000563 NAD(P) binding site [chemical binding]; other site 278137000564 catalytic residues [active] 278137000565 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 278137000566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 278137000567 NAD binding site [chemical binding]; other site 278137000568 homodimer interface [polypeptide binding]; other site 278137000569 active site 278137000570 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 278137000571 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 278137000572 NAD(P) binding site [chemical binding]; other site 278137000573 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 278137000574 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137000576 S-adenosylmethionine binding site [chemical binding]; other site 278137000577 Protein of unknown function (DUF456); Region: DUF456; cl01069 278137000578 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137000579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137000580 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 278137000581 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 278137000582 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 278137000583 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137000584 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 278137000585 FAD binding site [chemical binding]; other site 278137000586 substrate binding site [chemical binding]; other site 278137000587 catalytic base [active] 278137000588 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06069 278137000589 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 278137000590 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137000591 iron-sulfur cluster [ion binding]; other site 278137000592 [2Fe-2S] cluster binding site [ion binding]; other site 278137000593 Helix-turn-helix domain; Region: HTH_18; pfam12833 278137000594 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 278137000595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137000596 active site 278137000597 phosphorylation site [posttranslational modification] 278137000598 intermolecular recognition site; other site 278137000599 dimerization interface [polypeptide binding]; other site 278137000600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137000601 DNA binding residues [nucleotide binding] 278137000602 dimerization interface [polypeptide binding]; other site 278137000603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 278137000604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137000605 ATP binding site [chemical binding]; other site 278137000606 Mg2+ binding site [ion binding]; other site 278137000607 G-X-G motif; other site 278137000608 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 278137000609 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 278137000610 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 278137000611 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 278137000612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000613 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 278137000614 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 278137000615 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 278137000616 catalytic Zn binding site [ion binding]; other site 278137000617 NAD binding site [chemical binding]; other site 278137000618 structural Zn binding site [ion binding]; other site 278137000619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137000620 Helix-turn-helix domains; Region: HTH; cl00088 278137000621 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 278137000622 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 278137000623 metal binding site [ion binding]; metal-binding site 278137000624 Protein of unknown function DUF72; Region: DUF72; cl00777 278137000625 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 278137000626 putative hydrophobic ligand binding site [chemical binding]; other site 278137000627 Transcriptional regulators [Transcription]; Region: GntR; COG1802 278137000628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137000629 DNA-binding site [nucleotide binding]; DNA binding site 278137000630 FCD domain; Region: FCD; cl11656 278137000631 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 278137000632 AMP-binding enzyme; Region: AMP-binding; cl15778 278137000633 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137000634 Permease; Region: Permease; cl00510 278137000635 Permease; Region: Permease; cl00510 278137000636 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000637 mce related protein; Region: MCE; pfam02470 278137000638 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137000639 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000640 mce related protein; Region: MCE; pfam02470 278137000641 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000642 mce related protein; Region: MCE; pfam02470 278137000643 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 278137000644 mce related protein; Region: MCE; pfam02470 278137000645 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137000646 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000647 mce related protein; Region: MCE; pfam02470 278137000648 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000649 mce related protein; Region: MCE; pfam02470 278137000650 RDD family; Region: RDD; cl00746 278137000651 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 278137000652 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 278137000653 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 278137000654 Cupin domain; Region: Cupin_2; cl09118 278137000655 Peptidase family M48; Region: Peptidase_M48; cl12018 278137000656 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137000657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 278137000658 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137000659 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137000660 MULE transposase domain; Region: MULE; pfam10551 278137000661 Helix-turn-helix domains; Region: HTH; cl00088 278137000662 Transcriptional regulator [Transcription]; Region: IclR; COG1414 278137000663 Bacterial transcriptional regulator; Region: IclR; pfam01614 278137000664 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137000665 iron-sulfur cluster [ion binding]; other site 278137000666 [2Fe-2S] cluster binding site [ion binding]; other site 278137000667 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 278137000668 beta subunit interface [polypeptide binding]; other site 278137000669 alpha subunit interface [polypeptide binding]; other site 278137000670 active site 278137000671 substrate binding site [chemical binding]; other site 278137000672 Fe binding site [ion binding]; other site 278137000673 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 278137000674 inter-subunit interface; other site 278137000675 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 278137000676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000677 NAD(P) binding site [chemical binding]; other site 278137000678 active site 278137000679 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137000680 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 278137000681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 278137000682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137000683 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 278137000684 Cupin domain; Region: Cupin_2; cl09118 278137000685 Cupin domain; Region: Cupin_2; cl09118 278137000686 Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952 278137000687 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 278137000688 putative active site [active] 278137000689 catalytic residue [active] 278137000690 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 278137000691 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 278137000692 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 278137000693 active site 278137000694 Fe binding site [ion binding]; other site 278137000695 SCP-2 sterol transfer family; Region: SCP2; cl01225 278137000696 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137000697 catalytic residue [active] 278137000698 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 278137000699 inter-subunit interface; other site 278137000700 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 278137000701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000702 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 278137000703 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 278137000704 4Fe-4S binding domain; Region: Fer4; cl02805 278137000705 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137000706 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 278137000707 NAD(P) binding site [chemical binding]; other site 278137000708 catalytic residues [active] 278137000709 putative transposase OrfB; Reviewed; Region: PHA02517 278137000710 HTH-like domain; Region: HTH_21; pfam13276 278137000711 Integrase core domain; Region: rve; cl01316 278137000712 Integrase core domain; Region: rve_3; cl15866 278137000713 Helix-turn-helix domains; Region: HTH; cl00088 278137000714 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 278137000715 inter-subunit interface; other site 278137000716 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 278137000717 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 278137000718 alpha subunit interaction site [polypeptide binding]; other site 278137000719 beta subunit interaction site [polypeptide binding]; other site 278137000720 iron-sulfur cluster [ion binding]; other site 278137000721 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 278137000722 beta subunit interface [polypeptide binding]; other site 278137000723 alpha subunit interface [polypeptide binding]; other site 278137000724 active site 278137000725 substrate binding site [chemical binding]; other site 278137000726 Fe binding site [ion binding]; other site 278137000727 short chain dehydrogenase; Provisional; Region: PRK06138 278137000728 classical (c) SDRs; Region: SDR_c; cd05233 278137000729 NAD(P) binding site [chemical binding]; other site 278137000730 active site 278137000731 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137000732 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 278137000733 putative NAD(P) binding site [chemical binding]; other site 278137000734 catalytic Zn binding site [ion binding]; other site 278137000735 VPS10 domain; Region: VPS10; smart00602 278137000736 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 278137000737 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 278137000738 [2Fe-2S] cluster binding site [ion binding]; other site 278137000739 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137000740 hydrophobic ligand binding site; other site 278137000741 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137000742 SCP-2 sterol transfer family; Region: SCP2; cl01225 278137000743 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 278137000744 active site 278137000745 Permease; Region: Permease; cl00510 278137000746 Permease; Region: Permease; cl00510 278137000747 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000748 mce related protein; Region: MCE; pfam02470 278137000749 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137000750 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000751 mce related protein; Region: MCE; pfam02470 278137000752 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137000753 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000754 mce related protein; Region: MCE; pfam02470 278137000755 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000756 mce related protein; Region: MCE; pfam02470 278137000757 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137000758 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000759 mce related protein; Region: MCE; pfam02470 278137000760 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137000761 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137000762 mce related protein; Region: MCE; pfam02470 278137000763 Epoxide hydrolase N terminus; Region: EHN; pfam06441 278137000764 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137000765 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137000766 Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107 278137000767 NAD(P) binding site [chemical binding]; other site 278137000768 catalytic residues [active] 278137000769 catalytic residues [active] 278137000770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137000771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278137000772 putative substrate translocation pore; other site 278137000773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 278137000774 Transcriptional regulators [Transcription]; Region: MarR; COG1846 278137000775 Helix-turn-helix domains; Region: HTH; cl00088 278137000776 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 278137000777 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 278137000778 alpha subunit interaction site [polypeptide binding]; other site 278137000779 beta subunit interaction site [polypeptide binding]; other site 278137000780 iron-sulfur cluster [ion binding]; other site 278137000781 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 278137000782 beta subunit interface [polypeptide binding]; other site 278137000783 alpha subunit interface [polypeptide binding]; other site 278137000784 active site 278137000785 substrate binding site [chemical binding]; other site 278137000786 Fe binding site [ion binding]; other site 278137000787 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 278137000788 inter-subunit interface; other site 278137000789 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137000790 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 278137000791 putative NAD(P) binding site [chemical binding]; other site 278137000792 catalytic Zn binding site [ion binding]; other site 278137000793 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137000794 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137000795 lipid-transfer protein; Provisional; Region: PRK07855 278137000796 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137000797 active site 278137000798 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 278137000799 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137000800 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278137000801 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137000802 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 278137000803 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 278137000804 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137000805 iron-sulfur cluster [ion binding]; other site 278137000806 [2Fe-2S] cluster binding site [ion binding]; other site 278137000807 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 278137000808 beta subunit interface [polypeptide binding]; other site 278137000809 alpha subunit interface [polypeptide binding]; other site 278137000810 active site 278137000811 substrate binding site [chemical binding]; other site 278137000812 Fe binding site [ion binding]; other site 278137000813 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 278137000814 inter-subunit interface; other site 278137000815 Cupin domain; Region: Cupin_2; cl09118 278137000816 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 278137000817 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278137000818 Helix-turn-helix domains; Region: HTH; cl00088 278137000819 Helix-turn-helix domains; Region: HTH; cl00088 278137000820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137000821 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137000822 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137000823 iron-sulfur cluster [ion binding]; other site 278137000824 [2Fe-2S] cluster binding site [ion binding]; other site 278137000825 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 278137000826 beta subunit interface [polypeptide binding]; other site 278137000827 alpha subunit interface [polypeptide binding]; other site 278137000828 active site 278137000829 substrate binding site [chemical binding]; other site 278137000830 Fe binding site [ion binding]; other site 278137000831 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 278137000832 inter-subunit interface; other site 278137000833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000834 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 278137000835 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 278137000836 active site 278137000837 metal binding site [ion binding]; metal-binding site 278137000838 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 278137000839 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 278137000840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000841 NAD(P) binding site [chemical binding]; other site 278137000842 active site 278137000843 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 278137000844 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 278137000845 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 278137000846 active site 278137000847 Fe binding site [ion binding]; other site 278137000848 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 278137000849 alpha subunit interaction site [polypeptide binding]; other site 278137000850 beta subunit interaction site [polypeptide binding]; other site 278137000851 iron-sulfur cluster [ion binding]; other site 278137000852 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 278137000853 beta subunit interface [polypeptide binding]; other site 278137000854 alpha subunit interface [polypeptide binding]; other site 278137000855 active site 278137000856 substrate binding site [chemical binding]; other site 278137000857 Fe binding site [ion binding]; other site 278137000858 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 278137000859 inter-subunit interface; other site 278137000860 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137000861 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137000862 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137000863 MULE transposase domain; Region: MULE; pfam10551 278137000864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137000865 Helix-turn-helix domains; Region: HTH; cl00088 278137000866 HTH-like domain; Region: HTH_21; pfam13276 278137000867 Integrase core domain; Region: rve; cl01316 278137000868 Integrase core domain; Region: rve_3; cl15866 278137000869 putative transposase OrfB; Reviewed; Region: PHA02517 278137000870 HTH-like domain; Region: HTH_21; pfam13276 278137000871 Integrase core domain; Region: rve; cl01316 278137000872 Integrase core domain; Region: rve_3; cl15866 278137000873 Helix-turn-helix domains; Region: HTH; cl00088 278137000874 putative transposase OrfB; Reviewed; Region: PHA02517 278137000875 HTH-like domain; Region: HTH_21; pfam13276 278137000876 Integrase core domain; Region: rve; cl01316 278137000877 Integrase core domain; Region: rve_3; cl15866 278137000878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 278137000879 Helix-turn-helix domains; Region: HTH; cl00088 278137000880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137000881 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278137000882 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 278137000883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000884 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 278137000885 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 278137000886 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 278137000887 active site 278137000888 inhibitor site; inhibition site 278137000889 dimer interface [polypeptide binding]; other site 278137000890 catalytic residue [active] 278137000891 Helix-turn-helix domains; Region: HTH; cl00088 278137000892 Transcriptional regulator [Transcription]; Region: IclR; COG1414 278137000893 Bacterial transcriptional regulator; Region: IclR; pfam01614 278137000894 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 278137000895 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 278137000896 active site 278137000897 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 278137000898 active site 278137000899 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 278137000900 Lyase; Region: Lyase_1; pfam00206 278137000901 tetramer interface [polypeptide binding]; other site 278137000902 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 278137000903 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137000904 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137000905 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137000906 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 278137000907 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 278137000908 Cupin domain; Region: Cupin_2; cl09118 278137000909 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137000910 Transcriptional regulators [Transcription]; Region: MarR; COG1846 278137000911 Helix-turn-helix domains; Region: HTH; cl00088 278137000912 RNA polymerase factor sigma-70; Validated; Region: PRK08241 278137000913 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137000914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137000915 DNA binding residues [nucleotide binding] 278137000916 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137000917 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 278137000918 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137000919 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 278137000920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137000921 Helix-turn-helix domains; Region: HTH; cl00088 278137000922 putative transposase OrfB; Reviewed; Region: PHA02517 278137000923 HTH-like domain; Region: HTH_21; pfam13276 278137000924 Integrase core domain; Region: rve; cl01316 278137000925 Integrase core domain; Region: rve_3; cl15866 278137000926 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137000927 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 278137000928 putative hydrophobic ligand binding site [chemical binding]; other site 278137000929 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 278137000930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137000931 VCBS repeat; Region: VCBS_repeat; TIGR01965 278137000932 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 278137000933 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 278137000934 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 278137000935 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 278137000936 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 278137000937 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 278137000938 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 278137000939 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 278137000940 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 278137000941 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 278137000942 active site 278137000943 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 278137000944 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 278137000945 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 278137000946 ATP-binding site [chemical binding]; other site 278137000947 Gluconate-6-phosphate binding site [chemical binding]; other site 278137000948 Transcriptional regulators [Transcription]; Region: FadR; COG2186 278137000949 Helix-turn-helix domains; Region: HTH; cl00088 278137000950 DNA-binding site [nucleotide binding]; DNA binding site 278137000951 FCD domain; Region: FCD; cl11656 278137000952 DNA Topoisomerase IV; Region: TOP4c; smart00434 278137000953 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 278137000954 CAP-like domain; other site 278137000955 active site 278137000956 primary dimer interface [polypeptide binding]; other site 278137000957 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278137000958 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 278137000959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137000960 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 278137000961 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 278137000962 active site 278137000963 metal binding site [ion binding]; metal-binding site 278137000964 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 278137000965 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137000966 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 278137000967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000968 phosphoenolpyruvate synthase; Validated; Region: PRK06241 278137000969 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 278137000970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137000971 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 278137000972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137000973 Helix-turn-helix domains; Region: HTH; cl00088 278137000974 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 278137000975 hypothetical protein; Provisional; Region: PRK07877 278137000976 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 278137000977 Dehydratase family; Region: ILVD_EDD; cl00340 278137000978 Domain of unknown function (DUF305); Region: DUF305; cl15795 278137000979 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 278137000980 putative homotetramer interface [polypeptide binding]; other site 278137000981 putative homodimer interface [polypeptide binding]; other site 278137000982 putative allosteric switch controlling residues; other site 278137000983 putative metal binding site [ion binding]; other site 278137000984 putative homodimer-homodimer interface [polypeptide binding]; other site 278137000985 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 278137000986 putative ADP-binding pocket [chemical binding]; other site 278137000987 Domain of unknown function DUF77; Region: DUF77; cl00307 278137000988 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137000989 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 278137000990 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 278137000991 active site 278137000992 Zn binding site [ion binding]; other site 278137000993 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 278137000994 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 278137000995 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137000996 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 278137000997 active site 278137000998 TDP-binding site; other site 278137000999 acceptor substrate-binding pocket; other site 278137001000 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137001001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137001002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137001003 active site 278137001004 phosphorylation site [posttranslational modification] 278137001005 intermolecular recognition site; other site 278137001006 dimerization interface [polypeptide binding]; other site 278137001007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137001008 DNA binding site [nucleotide binding] 278137001009 sensory histidine kinase CreC; Provisional; Region: PRK11100 278137001010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137001011 phosphorylation site [posttranslational modification] 278137001012 dimer interface [polypeptide binding]; other site 278137001013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137001014 Mg2+ binding site [ion binding]; other site 278137001015 G-X-G motif; other site 278137001016 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 278137001017 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 278137001018 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 278137001019 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137001020 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 278137001021 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137001022 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 278137001023 LabA_like proteins; Region: LabA_like; cd06167 278137001024 putative metal binding site [ion binding]; other site 278137001025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137001026 S-adenosylmethionine binding site [chemical binding]; other site 278137001027 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 278137001028 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 278137001029 active site 278137001030 substrate-binding site [chemical binding]; other site 278137001031 metal-binding site [ion binding] 278137001032 GTP binding site [chemical binding]; other site 278137001033 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 278137001034 AMP-binding enzyme; Region: AMP-binding; cl15778 278137001035 AMP-binding enzyme; Region: AMP-binding; cl15778 278137001036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137001037 substrate binding site [chemical binding]; other site 278137001038 oxyanion hole (OAH) forming residues; other site 278137001039 trimer interface [polypeptide binding]; other site 278137001040 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278137001041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137001042 DNA-binding site [nucleotide binding]; DNA binding site 278137001043 UTRA domain; Region: UTRA; cl01230 278137001044 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137001045 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137001046 active site 278137001047 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278137001048 active site 2 [active] 278137001049 active site 1 [active] 278137001050 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278137001051 active site 2 [active] 278137001052 active site 1 [active] 278137001053 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137001054 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 278137001055 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137001056 active site 278137001057 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001058 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137001059 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137001060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137001061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137001062 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137001063 active site 278137001064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001065 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137001066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001067 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 278137001068 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137001069 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 278137001070 Helix-turn-helix domains; Region: HTH; cl00088 278137001071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001072 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137001073 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001074 acyl-CoA synthetase; Provisional; Region: PRK13382 278137001075 AMP-binding enzyme; Region: AMP-binding; cl15778 278137001076 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137001077 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 278137001078 putative acyl-acceptor binding pocket; other site 278137001079 N-acetyltransferase; Region: Acetyltransf_2; cl00949 278137001080 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278137001081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137001082 DinB superfamily; Region: DinB_2; pfam12867 278137001083 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 278137001084 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 278137001085 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 278137001086 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 278137001087 FAD binding site [chemical binding]; other site 278137001088 substrate binding site [chemical binding]; other site 278137001089 catalytic residues [active] 278137001090 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 278137001091 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137001092 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 278137001093 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137001094 NAD binding site [chemical binding]; other site 278137001095 catalytic residues [active] 278137001096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137001097 S-adenosylmethionine binding site [chemical binding]; other site 278137001098 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137001099 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 278137001100 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137001101 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137001102 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 278137001103 OpgC protein; Region: OpgC_C; cl00792 278137001104 Acyltransferase family; Region: Acyl_transf_3; pfam01757 278137001105 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 278137001106 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 278137001107 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137001108 Ligand Binding Site [chemical binding]; other site 278137001109 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 278137001110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137001111 Helix-turn-helix domains; Region: HTH; cl00088 278137001112 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278137001113 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278137001114 active site 2 [active] 278137001115 active site 1 [active] 278137001116 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 278137001117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001118 NAD(P) binding site [chemical binding]; other site 278137001119 active site 278137001120 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 278137001121 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137001122 dimer interface [polypeptide binding]; other site 278137001123 active site 278137001124 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 278137001125 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137001126 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 278137001127 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 278137001128 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 278137001129 FAD binding site [chemical binding]; other site 278137001130 substrate binding site [chemical binding]; other site 278137001131 catalytic residues [active] 278137001132 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 278137001133 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137001134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001136 NAD(P) binding site [chemical binding]; other site 278137001137 active site 278137001138 TspO/MBR family; Region: TspO_MBR; cl01379 278137001139 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 278137001140 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137001141 active site 278137001142 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 278137001143 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137001144 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 278137001145 putative NADP binding site [chemical binding]; other site 278137001146 active site 278137001147 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137001148 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 278137001149 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137001150 active site 278137001151 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137001152 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 278137001153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001154 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 278137001155 Enoylreductase; Region: PKS_ER; smart00829 278137001156 NAD(P) binding site [chemical binding]; other site 278137001157 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 278137001158 putative NADP binding site [chemical binding]; other site 278137001159 active site 278137001160 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137001161 Transport protein; Region: actII; TIGR00833 278137001162 acyl-CoA synthetase; Validated; Region: PRK05850 278137001163 AMP-binding enzyme; Region: AMP-binding; cl15778 278137001164 PE-PPE domain; Region: PE-PPE; pfam08237 278137001165 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 278137001166 Flavin Reductases; Region: FlaRed; cl00801 278137001167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137001168 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 278137001169 active site 278137001170 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 278137001171 Helix-turn-helix domains; Region: HTH; cl00088 278137001172 AsnC family; Region: AsnC_trans_reg; pfam01037 278137001173 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 278137001174 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 278137001175 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 278137001176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001177 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 278137001178 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 278137001179 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 278137001180 tetramer interface [polypeptide binding]; other site 278137001181 active site 278137001182 Mg2+/Mn2+ binding site [ion binding]; other site 278137001183 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 278137001184 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 278137001185 putative dimer interface [polypeptide binding]; other site 278137001186 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 278137001187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137001189 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 278137001190 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 278137001191 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 278137001192 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 278137001193 Integrase core domain; Region: rve; cl01316 278137001194 Integrase core domain; Region: rve_3; cl15866 278137001195 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 278137001196 4Fe-4S binding domain; Region: Fer4; cl02805 278137001197 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 278137001198 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 278137001199 putative active site [active] 278137001200 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 278137001201 putative active site [active] 278137001202 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 278137001203 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 278137001204 active site 278137001205 Helix-turn-helix domains; Region: HTH; cl00088 278137001206 DNA binding site [nucleotide binding] 278137001207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137001208 Coenzyme A binding pocket [chemical binding]; other site 278137001209 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 278137001210 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 278137001211 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 278137001212 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 278137001213 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 278137001214 intersubunit interface [polypeptide binding]; other site 278137001215 LysE type translocator; Region: LysE; cl00565 278137001216 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 278137001217 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137001218 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137001219 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 278137001220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001221 NAD(P) binding site [chemical binding]; other site 278137001222 active site 278137001223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137001224 Helix-turn-helix domains; Region: HTH; cl00088 278137001225 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137001226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137001227 Helix-turn-helix domains; Region: HTH; cl00088 278137001228 DNA-binding interface [nucleotide binding]; DNA binding site 278137001229 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137001230 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 278137001231 Helix-turn-helix domains; Region: HTH; cl00088 278137001232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137001233 dimerization interface [polypeptide binding]; other site 278137001234 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278137001235 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 278137001236 cobyric acid synthase; Provisional; Region: PRK00784 278137001237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001238 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001239 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 278137001240 catalytic triad [active] 278137001241 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 278137001242 hypothetical protein; Provisional; Region: PRK06062 278137001243 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137001244 inhibitor-cofactor binding pocket; inhibition site 278137001245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137001246 catalytic residue [active] 278137001247 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 278137001248 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137001249 tetrameric interface [polypeptide binding]; other site 278137001250 NAD binding site [chemical binding]; other site 278137001251 catalytic residues [active] 278137001252 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 278137001253 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 278137001254 Helix-turn-helix domains; Region: HTH; cl00088 278137001255 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 278137001256 homotrimer interface [polypeptide binding]; other site 278137001257 Walker A motif; other site 278137001258 GTP binding site [chemical binding]; other site 278137001259 Walker B motif; other site 278137001260 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 278137001261 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 278137001262 putative FMN binding site [chemical binding]; other site 278137001263 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278137001264 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 278137001265 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137001266 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 278137001267 Helix-turn-helix domains; Region: HTH; cl00088 278137001268 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 278137001269 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278137001270 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 278137001271 FAD binding pocket [chemical binding]; other site 278137001272 conserved FAD binding motif [chemical binding]; other site 278137001273 phosphate binding motif [ion binding]; other site 278137001274 beta-alpha-beta structure motif; other site 278137001275 NAD binding pocket [chemical binding]; other site 278137001276 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 278137001277 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 278137001278 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137001279 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 278137001280 active site 278137001281 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137001282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137001283 active site 278137001284 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137001285 anti sigma factor interaction site; other site 278137001286 regulatory phosphorylation site [posttranslational modification]; other site 278137001287 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 278137001288 nucleotide binding site [chemical binding]; other site 278137001289 acyl-CoA synthetase; Validated; Region: PRK07788 278137001290 AMP-binding enzyme; Region: AMP-binding; cl15778 278137001291 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137001292 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 278137001293 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 278137001294 putative dimer interface [polypeptide binding]; other site 278137001295 putative [2Fe-2S] cluster binding site [ion binding]; other site 278137001296 Cupin superfamily protein; Region: Cupin_4; pfam08007 278137001297 JmjC domain, hydroxylase; Region: JmjC; cl15814 278137001298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137001299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137001300 active site 278137001301 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137001302 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 278137001303 FAD binding site [chemical binding]; other site 278137001304 substrate binding site [chemical binding]; other site 278137001305 catalytic base [active] 278137001306 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 278137001307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001308 Esterase/lipase [General function prediction only]; Region: COG1647 278137001309 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 278137001310 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137001311 Zn binding site [ion binding]; other site 278137001312 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137001313 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 278137001314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137001315 Walker A motif; other site 278137001316 ATP binding site [chemical binding]; other site 278137001317 Walker B motif; other site 278137001318 arginine finger; other site 278137001319 Protein of unknown function (DUF690); Region: DUF690; cl04939 278137001320 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 278137001321 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001322 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 278137001323 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001324 PPE family; Region: PPE; pfam00823 278137001325 Proteins of 100 residues with WXG; Region: WXG100; cl02005 278137001326 EspG family; Region: ESX-1_EspG; pfam14011 278137001327 Ubiquitin-like proteins; Region: UBQ; cl00155 278137001328 Ubiquitin-like proteins; Region: UBQ; cl00155 278137001329 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 278137001330 active site 278137001331 catalytic residues [active] 278137001332 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 278137001333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137001334 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001335 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 278137001336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137001337 S-adenosylmethionine binding site [chemical binding]; other site 278137001338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 278137001339 Transposase; Region: DDE_Tnp_ISL3; pfam01610 278137001340 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137001341 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137001342 active site 278137001343 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 278137001344 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 278137001345 active site 278137001346 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 278137001347 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 278137001348 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137001349 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137001350 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 278137001351 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 278137001352 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 278137001353 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 278137001354 NAD binding site [chemical binding]; other site 278137001355 dimer interface [polypeptide binding]; other site 278137001356 substrate binding site [chemical binding]; other site 278137001357 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278137001358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001359 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137001360 NAD(P) binding site [chemical binding]; other site 278137001361 active site 278137001362 hypothetical protein; Provisional; Region: PRK06185 278137001363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001364 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 278137001365 putative catalytic site [active] 278137001366 putative metal binding site [ion binding]; other site 278137001367 putative phosphate binding site [ion binding]; other site 278137001368 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 278137001369 heme-binding site [chemical binding]; other site 278137001370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137001371 putative substrate translocation pore; other site 278137001372 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001373 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 278137001374 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 278137001375 active site 278137001376 catalytic residues [active] 278137001377 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 278137001378 Helix-turn-helix domains; Region: HTH; cl00088 278137001379 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137001380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001381 NAD(P) binding site [chemical binding]; other site 278137001382 active site 278137001383 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 278137001384 Fic family protein [Function unknown]; Region: COG3177 278137001385 Fic/DOC family; Region: Fic; cl00960 278137001386 Phage capsid family; Region: Phage_capsid; pfam05065 278137001387 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 278137001388 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278137001389 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 278137001390 Int/Topo IB signature motif; other site 278137001391 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 278137001392 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 278137001393 trimer interface [polypeptide binding]; other site 278137001394 active site 278137001395 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 278137001396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001397 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 278137001398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001399 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 278137001400 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137001401 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137001402 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 278137001403 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 278137001404 substrate binding site; other site 278137001405 tetramer interface; other site 278137001406 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 278137001407 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 278137001408 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 278137001409 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 278137001410 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 278137001411 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 278137001412 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 278137001413 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 278137001414 YibE/F-like protein; Region: YibE_F; cl02259 278137001415 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 278137001416 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 278137001417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278137001418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137001419 homodimer interface [polypeptide binding]; other site 278137001420 catalytic residue [active] 278137001421 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 278137001422 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 278137001423 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 278137001424 Cysteine-rich domain; Region: CCG; pfam02754 278137001425 Cysteine-rich domain; Region: CCG; pfam02754 278137001426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137001427 DNA binding residues [nucleotide binding] 278137001428 dimerization interface [polypeptide binding]; other site 278137001429 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 278137001430 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 278137001431 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001432 G1 box; other site 278137001433 GTP/Mg2+ binding site [chemical binding]; other site 278137001434 G2 box; other site 278137001435 Switch I region; other site 278137001436 G3 box; other site 278137001437 Switch II region; other site 278137001438 G4 box; other site 278137001439 G5 box; other site 278137001440 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001441 G1 box; other site 278137001442 GTP/Mg2+ binding site [chemical binding]; other site 278137001443 G2 box; other site 278137001444 Switch I region; other site 278137001445 G3 box; other site 278137001446 Switch II region; other site 278137001447 G4 box; other site 278137001448 G5 box; other site 278137001449 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 278137001450 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 278137001451 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137001452 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137001453 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137001454 TIGR03085 family protein; Region: TIGR03085 278137001455 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137001456 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 278137001457 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 278137001458 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 278137001459 mycothione reductase; Reviewed; Region: PRK07846 278137001460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137001461 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278137001462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 278137001463 Predicted kinase [General function prediction only]; Region: COG0645 278137001464 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001465 active site 278137001466 pyruvate kinase; Validated; Region: PRK08187 278137001467 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137001468 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137001469 active site 278137001470 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137001471 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 278137001472 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 278137001473 dimer interface [polypeptide binding]; other site 278137001474 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 278137001475 chaperone protein DnaJ; Provisional; Region: PRK14279 278137001476 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 278137001477 HSP70 interaction site [polypeptide binding]; other site 278137001478 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 278137001479 Zn binding sites [ion binding]; other site 278137001480 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 278137001481 dimer interface [polypeptide binding]; other site 278137001482 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278137001483 DNA binding residues [nucleotide binding] 278137001484 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278137001485 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 278137001486 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 278137001487 active site 278137001488 catalytic residues [active] 278137001489 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 278137001490 heme-binding site [chemical binding]; other site 278137001491 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 278137001492 FMN reductase; Validated; Region: fre; PRK08051 278137001493 FAD binding pocket [chemical binding]; other site 278137001494 FAD binding motif [chemical binding]; other site 278137001495 phosphate binding motif [ion binding]; other site 278137001496 beta-alpha-beta structure motif; other site 278137001497 NAD binding pocket [chemical binding]; other site 278137001498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137001499 Helix-turn-helix domains; Region: HTH; cl00088 278137001500 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 278137001501 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 278137001502 active site 278137001503 metal binding site [ion binding]; metal-binding site 278137001504 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 278137001505 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 278137001506 active site 278137001507 non-prolyl cis peptide bond; other site 278137001508 Sodium:solute symporter family; Region: SSF; cl00456 278137001509 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 278137001510 putative active site [active] 278137001511 putative metal binding residues [ion binding]; other site 278137001512 signature motif; other site 278137001513 putative dimer interface [polypeptide binding]; other site 278137001514 putative phosphate binding site [ion binding]; other site 278137001515 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 278137001516 Clp amino terminal domain; Region: Clp_N; pfam02861 278137001517 Clp amino terminal domain; Region: Clp_N; pfam02861 278137001518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137001519 Walker A motif; other site 278137001520 ATP binding site [chemical binding]; other site 278137001521 Walker B motif; other site 278137001522 arginine finger; other site 278137001523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137001524 Walker A motif; other site 278137001525 ATP binding site [chemical binding]; other site 278137001526 Walker B motif; other site 278137001527 arginine finger; other site 278137001528 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278137001529 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278137001530 classical (c) SDRs; Region: SDR_c; cd05233 278137001531 NAD(P) binding site [chemical binding]; other site 278137001532 active site 278137001533 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 278137001534 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 278137001535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137001536 putative substrate translocation pore; other site 278137001537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137001538 Helix-turn-helix domains; Region: HTH; cl00088 278137001539 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 278137001540 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 278137001541 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 278137001542 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278137001543 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 278137001544 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 278137001545 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 278137001546 NAD(P) binding site [chemical binding]; other site 278137001547 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 278137001548 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 278137001549 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137001550 active site 278137001551 intersubunit interface [polypeptide binding]; other site 278137001552 zinc binding site [ion binding]; other site 278137001553 Na+ binding site [ion binding]; other site 278137001554 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 278137001555 Cation efflux family; Region: Cation_efflux; cl00316 278137001556 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 278137001557 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 278137001558 active site 278137001559 putative substrate binding region [chemical binding]; other site 278137001560 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 278137001561 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 278137001562 GDP-binding site [chemical binding]; other site 278137001563 ACT binding site; other site 278137001564 IMP binding site; other site 278137001565 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137001566 CoenzymeA binding site [chemical binding]; other site 278137001567 subunit interaction site [polypeptide binding]; other site 278137001568 PHB binding site; other site 278137001569 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137001570 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137001571 Transport protein; Region: actII; TIGR00833 278137001572 Transport protein; Region: actII; TIGR00833 278137001573 Helix-turn-helix domains; Region: HTH; cl00088 278137001574 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 278137001575 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137001576 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 278137001577 active site residue [active] 278137001578 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 278137001579 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 278137001580 homodimer interface [polypeptide binding]; other site 278137001581 substrate-cofactor binding pocket; other site 278137001582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137001583 catalytic residue [active] 278137001584 short chain dehydrogenase; Provisional; Region: PRK07825 278137001585 classical (c) SDRs; Region: SDR_c; cd05233 278137001586 NAD(P) binding site [chemical binding]; other site 278137001587 active site 278137001588 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137001589 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 278137001590 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137001591 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 278137001592 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137001593 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 278137001594 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137001595 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 278137001596 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137001597 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137001598 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 278137001599 putative catalytic site [active] 278137001600 putative phosphate binding site [ion binding]; other site 278137001601 putative metal binding site [ion binding]; other site 278137001602 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 278137001603 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 278137001604 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 278137001605 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 278137001606 DXD motif; other site 278137001607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001608 phosphate acetyltransferase; Reviewed; Region: PRK05632 278137001609 DRTGG domain; Region: DRTGG; cl12147 278137001610 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 278137001611 Acetokinase family; Region: Acetate_kinase; cl01029 278137001612 acetate kinase; Region: ackA; TIGR00016 278137001613 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137001614 anti sigma factor interaction site; other site 278137001615 regulatory phosphorylation site [posttranslational modification]; other site 278137001616 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137001617 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137001618 active site 278137001619 ATP binding site [chemical binding]; other site 278137001620 substrate binding site [chemical binding]; other site 278137001621 activation loop (A-loop); other site 278137001622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137001623 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278137001624 substrate binding pocket [chemical binding]; other site 278137001625 membrane-bound complex binding site; other site 278137001626 hinge residues; other site 278137001627 CobD/Cbib protein; Region: CobD_Cbib; cl00561 278137001628 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 278137001629 nudix motif; other site 278137001630 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 278137001631 thiamine phosphate binding site [chemical binding]; other site 278137001632 active site 278137001633 pyrophosphate binding site [ion binding]; other site 278137001634 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 278137001635 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 278137001636 thiS-thiF/thiG interaction site; other site 278137001637 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 278137001638 ThiS interaction site; other site 278137001639 putative active site [active] 278137001640 tetramer interface [polypeptide binding]; other site 278137001641 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 278137001642 active site 278137001643 catalytic triad [active] 278137001644 oxyanion hole [active] 278137001645 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 278137001646 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 278137001647 Walker A/P-loop; other site 278137001648 ATP binding site [chemical binding]; other site 278137001649 Q-loop/lid; other site 278137001650 ABC transporter signature motif; other site 278137001651 Walker B; other site 278137001652 D-loop; other site 278137001653 H-loop/switch region; other site 278137001654 short chain dehydrogenase; Validated; Region: PRK05855 278137001655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137001656 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 278137001657 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 278137001658 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 278137001659 PA/protease or protease-like domain interface [polypeptide binding]; other site 278137001660 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 278137001661 active site 278137001662 metal binding site [ion binding]; metal-binding site 278137001663 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 278137001664 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 278137001665 PA/protease or protease-like domain interface [polypeptide binding]; other site 278137001666 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 278137001667 active site 278137001668 metal binding site [ion binding]; metal-binding site 278137001669 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 278137001670 cationic amino acid transport permease; Region: 2A0303; TIGR00906 278137001671 Spore germination protein; Region: Spore_permease; cl15802 278137001672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137001673 Helix-turn-helix domains; Region: HTH; cl00088 278137001674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137001675 Helix-turn-helix domains; Region: HTH; cl00088 278137001676 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137001677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001678 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 278137001679 Septum formation; Region: Septum_form; pfam13845 278137001680 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 278137001681 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001682 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 278137001683 dimer interface [polypeptide binding]; other site 278137001684 substrate binding site [chemical binding]; other site 278137001685 ATP binding site [chemical binding]; other site 278137001686 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137001687 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137001688 active site 278137001689 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 278137001690 putative catalytic site [active] 278137001691 putative phosphate binding site [ion binding]; other site 278137001692 active site 278137001693 metal binding site A [ion binding]; metal-binding site 278137001694 DNA binding site [nucleotide binding] 278137001695 putative AP binding site [nucleotide binding]; other site 278137001696 putative metal binding site B [ion binding]; other site 278137001697 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 278137001698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137001699 Coenzyme A binding pocket [chemical binding]; other site 278137001700 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 278137001701 active site 278137001702 catalytic residues [active] 278137001703 metal binding site [ion binding]; metal-binding site 278137001704 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 278137001705 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 278137001706 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 278137001707 E-class dimer interface [polypeptide binding]; other site 278137001708 P-class dimer interface [polypeptide binding]; other site 278137001709 active site 278137001710 Cu2+ binding site [ion binding]; other site 278137001711 Zn2+ binding site [ion binding]; other site 278137001712 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 278137001713 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 278137001714 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 278137001715 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137001716 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 278137001717 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 278137001718 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 278137001719 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 278137001720 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 278137001721 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 278137001722 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 278137001723 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 278137001724 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 278137001725 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 278137001726 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 278137001727 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 278137001728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001729 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 278137001730 potassium/proton antiporter; Reviewed; Region: PRK05326 278137001731 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 278137001732 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 278137001733 2TM domain; Region: 2TM; pfam13239 278137001734 Proteins of 100 residues with WXG; Region: WXG100; cl02005 278137001735 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 278137001736 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 278137001737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137001739 Walker A motif; other site 278137001740 ATP binding site [chemical binding]; other site 278137001741 Walker B motif; other site 278137001742 arginine finger; other site 278137001743 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 278137001744 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 278137001745 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 278137001746 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 278137001747 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 278137001748 dimer interface [polypeptide binding]; other site 278137001749 putative functional site; other site 278137001750 putative MPT binding site; other site 278137001751 short chain dehydrogenase; Provisional; Region: PRK06197 278137001752 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 278137001753 putative NAD(P) binding site [chemical binding]; other site 278137001754 active site 278137001755 Bacterial PH domain; Region: DUF304; cl01348 278137001756 Predicted membrane protein [Function unknown]; Region: COG3428 278137001757 Bacterial PH domain; Region: DUF304; cl01348 278137001758 Predicted membrane protein [Function unknown]; Region: COG3428 278137001759 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 278137001760 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 278137001761 DNA binding residues [nucleotide binding] 278137001762 dimer interface [polypeptide binding]; other site 278137001763 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 278137001764 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 278137001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137001766 active site 278137001767 motif I; other site 278137001768 motif II; other site 278137001769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137001770 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 278137001771 putative hydrophobic ligand binding site [chemical binding]; other site 278137001772 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 278137001773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137001774 ATP binding site [chemical binding]; other site 278137001775 putative Mg++ binding site [ion binding]; other site 278137001776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137001777 nucleotide binding region [chemical binding]; other site 278137001778 ATP-binding site [chemical binding]; other site 278137001779 Cupin domain; Region: Cupin_2; cl09118 278137001780 short chain dehydrogenase; Provisional; Region: PRK06197 278137001781 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 278137001782 putative NAD(P) binding site [chemical binding]; other site 278137001783 active site 278137001784 Helix-turn-helix domains; Region: HTH; cl00088 278137001785 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 278137001786 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 278137001787 ring oligomerisation interface [polypeptide binding]; other site 278137001788 ATP/Mg binding site [chemical binding]; other site 278137001789 stacking interactions; other site 278137001790 hinge regions; other site 278137001791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137001792 metabolite-proton symporter; Region: 2A0106; TIGR00883 278137001793 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137001794 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137001795 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 278137001796 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 278137001797 active site 278137001798 putative substrate binding pocket [chemical binding]; other site 278137001799 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137001800 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 278137001801 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137001802 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137001803 DinB superfamily; Region: DinB_2; pfam12867 278137001804 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 278137001805 active site 278137001806 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137001807 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 278137001808 NAD(P) binding site [chemical binding]; other site 278137001809 catalytic residues [active] 278137001810 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278137001811 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 278137001812 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137001813 Integrase core domain; Region: rve; cl01316 278137001814 Integrase core domain; Region: rve_3; cl15866 278137001815 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137001816 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137001817 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137001818 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 278137001819 putative NAD(P) binding site [chemical binding]; other site 278137001820 catalytic Zn binding site [ion binding]; other site 278137001821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001822 acetoin reductases; Region: 23BDH; TIGR02415 278137001823 NAD(P) binding site [chemical binding]; other site 278137001824 active site 278137001825 GAF domain; Region: GAF; cl15785 278137001826 Protein of unknown function (DUF779); Region: DUF779; cl01432 278137001827 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 278137001828 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 278137001829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137001830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137001831 dimer interface [polypeptide binding]; other site 278137001832 conserved gate region; other site 278137001833 putative PBP binding loops; other site 278137001834 ABC-ATPase subunit interface; other site 278137001835 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 278137001836 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 278137001837 Walker A/P-loop; other site 278137001838 ATP binding site [chemical binding]; other site 278137001839 Q-loop/lid; other site 278137001840 ABC transporter signature motif; other site 278137001841 Walker B; other site 278137001842 D-loop; other site 278137001843 H-loop/switch region; other site 278137001844 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 278137001845 Walker A/P-loop; other site 278137001846 ATP binding site [chemical binding]; other site 278137001847 ABC transporter; Region: ABC_tran; pfam00005 278137001848 Q-loop/lid; other site 278137001849 ABC transporter signature motif; other site 278137001850 Walker B; other site 278137001851 D-loop; other site 278137001852 H-loop/switch region; other site 278137001853 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 278137001854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137001856 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278137001857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137001858 metal binding site [ion binding]; metal-binding site 278137001859 active site 278137001860 I-site; other site 278137001861 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137001862 Uncharacterized conserved protein [Function unknown]; Region: COG2128 278137001863 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137001864 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278137001865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137001866 non-specific DNA binding site [nucleotide binding]; other site 278137001867 salt bridge; other site 278137001868 sequence-specific DNA binding site [nucleotide binding]; other site 278137001869 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 278137001870 Domain of unknown function (DUF955); Region: DUF955; cl01076 278137001871 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 278137001872 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 278137001873 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 278137001874 tetramer interface [polypeptide binding]; other site 278137001875 active site 278137001876 Mg2+/Mn2+ binding site [ion binding]; other site 278137001877 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 278137001878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001879 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 278137001880 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 278137001881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137001882 Helix-turn-helix domains; Region: HTH; cl00088 278137001883 Predicted membrane protein [Function unknown]; Region: COG2733 278137001884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137001885 non-specific DNA binding site [nucleotide binding]; other site 278137001886 salt bridge; other site 278137001887 sequence-specific DNA binding site [nucleotide binding]; other site 278137001888 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 278137001889 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 278137001890 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137001891 catalytic residue [active] 278137001892 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 278137001893 Predicted amidohydrolase [General function prediction only]; Region: COG0388 278137001894 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 278137001895 putative active site [active] 278137001896 catalytic triad [active] 278137001897 putative dimer interface [polypeptide binding]; other site 278137001898 Arginase family; Region: Arginase; cl00306 278137001899 ykkC-yxkD element 278137001900 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 278137001901 Na binding site [ion binding]; other site 278137001902 putative glycosylation site [posttranslational modification]; other site 278137001903 putative glycosylation site [posttranslational modification]; other site 278137001904 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 278137001905 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 278137001906 FAD binding domain; Region: FAD_binding_4; pfam01565 278137001907 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 278137001908 Bacterial Ig-like domain; Region: Big_5; cl01012 278137001909 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137001910 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 278137001911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001912 NAD(P) binding site [chemical binding]; other site 278137001913 active site 278137001914 Helix-turn-helix domains; Region: HTH; cl00088 278137001915 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278137001916 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278137001917 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 278137001918 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 278137001919 putative ADP-binding pocket [chemical binding]; other site 278137001920 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 278137001921 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137001922 catalytic core [active] 278137001923 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137001924 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 278137001925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137001926 dimer interface [polypeptide binding]; other site 278137001927 phosphorylation site [posttranslational modification] 278137001928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137001929 ATP binding site [chemical binding]; other site 278137001930 Mg2+ binding site [ion binding]; other site 278137001931 G-X-G motif; other site 278137001932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137001933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137001934 active site 278137001935 phosphorylation site [posttranslational modification] 278137001936 intermolecular recognition site; other site 278137001937 dimerization interface [polypeptide binding]; other site 278137001938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137001939 DNA binding site [nucleotide binding] 278137001940 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 278137001941 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 278137001942 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 278137001943 AP (apurinic/apyrimidinic) site pocket; other site 278137001944 Metal-binding active site; metal-binding site 278137001945 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 278137001946 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 278137001947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137001948 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278137001949 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 278137001950 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 278137001951 putative NAD(P) binding site [chemical binding]; other site 278137001952 active site 278137001953 putative substrate binding site [chemical binding]; other site 278137001954 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 278137001955 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 278137001956 putative acyl-acceptor binding pocket; other site 278137001957 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 278137001958 active site 278137001959 catalytic site [active] 278137001960 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 278137001961 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137001962 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137001963 MULE transposase domain; Region: MULE; pfam10551 278137001964 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 278137001965 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 278137001966 tRNA; other site 278137001967 putative tRNA binding site [nucleotide binding]; other site 278137001968 putative NADP binding site [chemical binding]; other site 278137001969 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 278137001970 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 278137001971 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 278137001972 domain interfaces; other site 278137001973 active site 278137001974 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278137001975 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 278137001976 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 278137001977 active site 278137001978 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 278137001979 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 278137001980 dimer interface [polypeptide binding]; other site 278137001981 active site 278137001982 Schiff base residues; other site 278137001983 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137001984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137001985 Helix-turn-helix domains; Region: HTH; cl00088 278137001986 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137001987 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 278137001988 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 278137001989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137001990 inhibitor-cofactor binding pocket; inhibition site 278137001991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137001992 catalytic residue [active] 278137001993 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137001994 catalytic core [active] 278137001995 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 278137001996 catalytic residues [active] 278137001997 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 278137001998 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 278137001999 ResB-like family; Region: ResB; pfam05140 278137002000 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 278137002001 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 278137002002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137002003 P-loop; other site 278137002004 Magnesium ion binding site [ion binding]; other site 278137002005 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137002006 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137002007 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 278137002008 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 278137002009 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137002010 MoxR-like ATPases [General function prediction only]; Region: COG0714 278137002011 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137002012 UbiA prenyltransferase family; Region: UbiA; cl00337 278137002013 Helix-turn-helix domains; Region: HTH; cl00088 278137002014 Winged helix-turn helix; Region: HTH_29; pfam13551 278137002015 Integrase core domain; Region: rve; cl01316 278137002016 Integrase core domain; Region: rve_3; cl15866 278137002017 Nitronate monooxygenase; Region: NMO; pfam03060 278137002018 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137002019 FMN binding site [chemical binding]; other site 278137002020 substrate binding site [chemical binding]; other site 278137002021 putative catalytic residue [active] 278137002022 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 278137002023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137002024 dimer interface [polypeptide binding]; other site 278137002025 phosphorylation site [posttranslational modification] 278137002026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137002027 ATP binding site [chemical binding]; other site 278137002028 Mg2+ binding site [ion binding]; other site 278137002029 G-X-G motif; other site 278137002030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137002031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137002032 active site 278137002033 phosphorylation site [posttranslational modification] 278137002034 intermolecular recognition site; other site 278137002035 dimerization interface [polypeptide binding]; other site 278137002036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137002037 DNA binding site [nucleotide binding] 278137002038 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137002039 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002040 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 278137002041 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137002042 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 278137002043 Phosphate transporter family; Region: PHO4; cl00396 278137002044 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 278137002045 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137002046 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 278137002047 active site 278137002048 metal binding site [ion binding]; metal-binding site 278137002049 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 278137002050 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002051 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137002052 short chain dehydrogenase; Provisional; Region: PRK05866 278137002053 classical (c) SDRs; Region: SDR_c; cd05233 278137002054 NAD(P) binding site [chemical binding]; other site 278137002055 active site 278137002056 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137002057 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 278137002058 substrate binding site [chemical binding]; other site 278137002059 oxyanion hole (OAH) forming residues; other site 278137002060 trimer interface [polypeptide binding]; other site 278137002061 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137002062 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 278137002063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137002064 motif II; other site 278137002065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137002066 active site 278137002067 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002068 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 278137002069 Nodulation protein S (NodS); Region: NodS; pfam05401 278137002070 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 278137002071 Transcriptional regulators [Transcription]; Region: FadR; COG2186 278137002072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137002073 DNA-binding site [nucleotide binding]; DNA binding site 278137002074 FCD domain; Region: FCD; cl11656 278137002075 acyl-CoA synthetase; Validated; Region: PRK06188 278137002076 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002077 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137002079 Helix-turn-helix domains; Region: HTH; cl00088 278137002080 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 278137002081 Helix-turn-helix domains; Region: HTH; cl00088 278137002082 Permease; Region: Permease; cl00510 278137002083 Permease; Region: Permease; cl00510 278137002084 mce related protein; Region: MCE; pfam02470 278137002085 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137002086 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002087 mce related protein; Region: MCE; pfam02470 278137002088 mce related protein; Region: MCE; pfam02470 278137002089 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002090 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002091 mce related protein; Region: MCE; pfam02470 278137002092 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002093 mce related protein; Region: MCE; pfam02470 278137002094 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002095 mce related protein; Region: MCE; pfam02470 278137002096 Mannan-binding protein; Region: MVL; pfam12151 278137002097 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137002098 Helix-turn-helix domains; Region: HTH; cl00088 278137002099 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 278137002100 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 278137002101 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002102 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137002103 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 278137002104 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 278137002105 O-succinylbenzoate synthase; Provisional; Region: PRK02901 278137002106 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137002107 metal binding site [ion binding]; metal-binding site 278137002108 substrate binding pocket [chemical binding]; other site 278137002109 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 278137002110 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 278137002111 conserved cys residue [active] 278137002112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137002113 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 278137002114 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 278137002115 conserved cys residue [active] 278137002116 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 278137002117 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 278137002118 putative active site [active] 278137002119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137002120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137002121 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 278137002122 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 278137002123 dimer interface [polypeptide binding]; other site 278137002124 tetramer interface [polypeptide binding]; other site 278137002125 PYR/PP interface [polypeptide binding]; other site 278137002126 TPP binding site [chemical binding]; other site 278137002127 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 278137002128 TPP-binding site; other site 278137002129 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 278137002130 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 278137002131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137002132 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 278137002133 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137002134 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 278137002135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137002136 S-adenosylmethionine binding site [chemical binding]; other site 278137002137 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 278137002138 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137002139 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 278137002140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002141 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 278137002142 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 278137002143 substrate binding pocket [chemical binding]; other site 278137002144 chain length determination region; other site 278137002145 substrate-Mg2+ binding site; other site 278137002146 catalytic residues [active] 278137002147 aspartate-rich region 1; other site 278137002148 active site lid residues [active] 278137002149 aspartate-rich region 2; other site 278137002150 Peptidase family M48; Region: Peptidase_M48; cl12018 278137002151 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 278137002152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002153 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 278137002154 Protein of unknown function (DUF520); Region: DUF520; cl00723 278137002155 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 278137002156 FAD binding pocket [chemical binding]; other site 278137002157 FAD binding motif [chemical binding]; other site 278137002158 phosphate binding motif [ion binding]; other site 278137002159 beta-alpha-beta structure motif; other site 278137002160 NAD binding pocket [chemical binding]; other site 278137002161 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137002162 catalytic loop [active] 278137002163 iron binding site [ion binding]; other site 278137002164 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 278137002165 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 278137002166 putative di-iron ligands [ion binding]; other site 278137002167 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 278137002168 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 278137002169 PE-PPE domain; Region: PE-PPE; pfam08237 278137002170 short chain dehydrogenase; Validated; Region: PRK06182 278137002171 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 278137002172 NADP binding site [chemical binding]; other site 278137002173 active site 278137002174 steroid binding site; other site 278137002175 Cupin domain; Region: Cupin_2; cl09118 278137002176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137002177 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278137002178 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 278137002179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002180 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137002181 Helix-turn-helix domains; Region: HTH; cl00088 278137002182 SCP-2 sterol transfer family; Region: SCP2; cl01225 278137002183 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137002184 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137002185 active site 278137002186 ATP binding site [chemical binding]; other site 278137002187 substrate binding site [chemical binding]; other site 278137002188 activation loop (A-loop); other site 278137002189 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137002190 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278137002191 substrate binding pocket [chemical binding]; other site 278137002192 membrane-bound complex binding site; other site 278137002193 hinge residues; other site 278137002194 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 278137002195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137002196 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137002197 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002198 Cytochrome P450; Region: p450; pfam00067 278137002199 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 278137002200 DNA-binding site [nucleotide binding]; DNA binding site 278137002201 RNA-binding motif; other site 278137002202 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 278137002203 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 278137002204 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 278137002205 DNA-binding site [nucleotide binding]; DNA binding site 278137002206 RNA-binding motif; other site 278137002207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137002208 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 278137002209 alanine dehydrogenase; Region: alaDH; TIGR00518 278137002210 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 278137002211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002212 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 278137002213 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 278137002214 putative di-iron ligands [ion binding]; other site 278137002215 GAF domain; Region: GAF; cl15785 278137002216 ANTAR domain; Region: ANTAR; cl04297 278137002217 GAF domain; Region: GAF_2; pfam13185 278137002218 GAF domain; Region: GAF; cl15785 278137002219 ANTAR domain; Region: ANTAR; cl04297 278137002220 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 278137002221 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002222 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 278137002223 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 278137002224 active site 278137002225 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 278137002226 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 278137002227 putative di-iron ligands [ion binding]; other site 278137002228 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137002229 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 278137002230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137002231 Helix-turn-helix domains; Region: HTH; cl00088 278137002232 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 278137002233 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137002234 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137002235 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137002236 active site 278137002237 ATP binding site [chemical binding]; other site 278137002238 substrate binding site [chemical binding]; other site 278137002239 activation loop (A-loop); other site 278137002240 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 278137002241 Transglycosylase; Region: Transgly; cl07896 278137002242 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137002243 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278137002244 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 278137002245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137002246 putative substrate translocation pore; other site 278137002247 Z1 domain; Region: Z1; pfam10593 278137002248 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 278137002249 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 278137002250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137002251 ATP binding site [chemical binding]; other site 278137002252 Mg2+ binding site [ion binding]; other site 278137002253 G-X-G motif; other site 278137002254 Protein of unknown function (DUF499); Region: DUF499; pfam04465 278137002255 Protein of unknown function DUF262; Region: DUF262; cl14890 278137002256 Protein of unknown function DUF262; Region: DUF262; cl14890 278137002257 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137002258 MULE transposase domain; Region: MULE; pfam10551 278137002259 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 278137002260 Short C-terminal domain; Region: SHOCT; cl01373 278137002261 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 278137002262 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 278137002263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137002264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137002265 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137002266 MULE transposase domain; Region: MULE; pfam10551 278137002267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137002268 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137002269 active site 278137002270 DNA binding site [nucleotide binding] 278137002271 Int/Topo IB signature motif; other site 278137002272 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 278137002273 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137002274 dimer interface [polypeptide binding]; other site 278137002275 active site 278137002276 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002277 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002278 active site 278137002279 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002280 active site 278137002281 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137002282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002283 active site 278137002284 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 278137002285 active site 278137002286 catalytic site [active] 278137002287 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 278137002288 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137002289 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 278137002290 putative active site [active] 278137002291 putative catalytic site [active] 278137002292 lipid-transfer protein; Provisional; Region: PRK07855 278137002293 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137002294 active site 278137002295 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 278137002296 enoyl-CoA hydratase; Region: PLN02864 278137002297 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278137002298 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 278137002299 dimer interaction site [polypeptide binding]; other site 278137002300 substrate-binding tunnel; other site 278137002301 active site 278137002302 catalytic site [active] 278137002303 substrate binding site [chemical binding]; other site 278137002304 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 278137002305 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 278137002306 acetaldehyde dehydrogenase; Validated; Region: PRK08300 278137002307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002308 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 278137002309 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 278137002310 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 278137002311 active site 278137002312 catalytic residues [active] 278137002313 metal binding site [ion binding]; metal-binding site 278137002314 DmpG-like communication domain; Region: DmpG_comm; pfam07836 278137002315 Haemolysin-III related; Region: HlyIII; cl03831 278137002316 Cytochrome P450; Region: p450; pfam00067 278137002317 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002318 Transcriptional regulator [Transcription]; Region: IclR; COG1414 278137002319 Helix-turn-helix domains; Region: HTH; cl00088 278137002320 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137002321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002322 NAD(P) binding site [chemical binding]; other site 278137002323 active site 278137002324 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 278137002325 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 278137002326 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 278137002327 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137002328 hydrophobic ligand binding site; other site 278137002329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137002330 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 278137002331 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137002332 active site 278137002333 lipid-transfer protein; Provisional; Region: PRK07937 278137002334 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137002335 active site 278137002336 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 278137002337 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137002338 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 278137002339 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137002340 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137002341 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 278137002342 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 278137002343 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002344 enoyl-CoA hydratase; Provisional; Region: PRK07799 278137002345 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137002346 substrate binding site [chemical binding]; other site 278137002347 oxyanion hole (OAH) forming residues; other site 278137002348 trimer interface [polypeptide binding]; other site 278137002349 acyl-CoA synthetase; Validated; Region: PRK07798 278137002350 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002351 Nitronate monooxygenase; Region: NMO; pfam03060 278137002352 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137002353 FMN binding site [chemical binding]; other site 278137002354 substrate binding site [chemical binding]; other site 278137002355 putative catalytic residue [active] 278137002356 hypothetical protein; Validated; Region: PRK07586 278137002357 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 278137002358 PYR/PP interface [polypeptide binding]; other site 278137002359 dimer interface [polypeptide binding]; other site 278137002360 TPP binding site [chemical binding]; other site 278137002361 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 278137002362 TPP-binding site [chemical binding]; other site 278137002363 dimer interface [polypeptide binding]; other site 278137002364 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 278137002365 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 278137002366 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 278137002367 acyl-CoA synthetase; Provisional; Region: PRK13388 278137002368 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002369 acyl-CoA synthetase; Validated; Region: PRK07867 278137002370 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002371 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137002373 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002374 active site 278137002375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137002376 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 278137002377 FAD binding site [chemical binding]; other site 278137002378 substrate binding site [chemical binding]; other site 278137002379 catalytic base [active] 278137002380 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137002381 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 278137002382 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 278137002383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002384 NAD(P) binding site [chemical binding]; other site 278137002385 active site 278137002386 Permease; Region: Permease; cl00510 278137002387 Permease; Region: Permease; cl00510 278137002388 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002389 mce related protein; Region: MCE; pfam02470 278137002390 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137002391 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002392 mce related protein; Region: MCE; pfam02470 278137002393 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002394 mce related protein; Region: MCE; pfam02470 278137002395 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137002396 mce related protein; Region: MCE; pfam02470 278137002397 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137002398 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002399 mce related protein; Region: MCE; pfam02470 278137002400 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137002401 mce related protein; Region: MCE; pfam02470 278137002402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002403 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 278137002404 NAD(P) binding site [chemical binding]; other site 278137002405 active site 278137002406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002407 NAD(P) binding site [chemical binding]; other site 278137002408 active site 278137002409 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 278137002410 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 278137002411 active site 278137002412 homotetramer interface [polypeptide binding]; other site 278137002413 enoyl-CoA hydratase; Provisional; Region: PRK08290 278137002414 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137002415 substrate binding site [chemical binding]; other site 278137002416 oxyanion hole (OAH) forming residues; other site 278137002417 trimer interface [polypeptide binding]; other site 278137002418 classical (c) SDRs; Region: SDR_c; cd05233 278137002419 NAD(P) binding site [chemical binding]; other site 278137002420 active site 278137002421 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 278137002422 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 278137002423 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 278137002424 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 278137002425 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 278137002426 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 278137002427 putative hydrophobic ligand binding site [chemical binding]; other site 278137002428 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 278137002429 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 278137002430 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 278137002431 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 278137002432 XdhC Rossmann domain; Region: XdhC_C; pfam13478 278137002433 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 278137002434 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 278137002435 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 278137002436 HNH endonuclease; Region: HNH_3; pfam13392 278137002437 HNH endonuclease; Region: HNH_3; pfam13392 278137002438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137002439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137002440 active site 278137002441 phosphorylation site [posttranslational modification] 278137002442 intermolecular recognition site; other site 278137002443 dimerization interface [polypeptide binding]; other site 278137002444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137002445 DNA binding site [nucleotide binding] 278137002446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 278137002447 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278137002448 dimerization interface [polypeptide binding]; other site 278137002449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137002450 dimer interface [polypeptide binding]; other site 278137002451 phosphorylation site [posttranslational modification] 278137002452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137002453 ATP binding site [chemical binding]; other site 278137002454 Mg2+ binding site [ion binding]; other site 278137002455 G-X-G motif; other site 278137002456 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 278137002457 nucleotide binding site/active site [active] 278137002458 HIT family signature motif; other site 278137002459 catalytic residue [active] 278137002460 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 278137002461 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002462 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137002463 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137002464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002465 NAD(P) binding site [chemical binding]; other site 278137002466 active site 278137002467 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002468 Helix-turn-helix domains; Region: HTH; cl00088 278137002469 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137002470 classical (c) SDRs; Region: SDR_c; cd05233 278137002471 NAD(P) binding site [chemical binding]; other site 278137002472 active site 278137002473 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137002474 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 278137002475 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 278137002476 classical (c) SDRs; Region: SDR_c; cd05233 278137002477 NAD(P) binding site [chemical binding]; other site 278137002478 active site 278137002479 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 278137002480 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137002481 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137002482 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 278137002483 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 278137002484 NAD binding site [chemical binding]; other site 278137002485 catalytic Zn binding site [ion binding]; other site 278137002486 substrate binding site [chemical binding]; other site 278137002487 structural Zn binding site [ion binding]; other site 278137002488 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 278137002489 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137002490 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002491 Cytochrome P450; Region: p450; pfam00067 278137002492 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 278137002493 classical (c) SDRs; Region: SDR_c; cd05233 278137002494 NAD(P) binding site [chemical binding]; other site 278137002495 active site 278137002496 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002497 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137002498 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 278137002499 NAD binding site [chemical binding]; other site 278137002500 catalytic residues [active] 278137002501 classical (c) SDRs; Region: SDR_c; cd05233 278137002502 NAD(P) binding site [chemical binding]; other site 278137002503 active site 278137002504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002505 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 278137002506 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137002507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137002508 Helix-turn-helix domains; Region: HTH; cl00088 278137002509 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002510 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 278137002511 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 278137002512 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137002513 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 278137002514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 278137002515 amino acid transporter; Region: 2A0306; TIGR00909 278137002516 Spore germination protein; Region: Spore_permease; cl15802 278137002517 Protein of unknown function (DUF429); Region: DUF429; cl12046 278137002518 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 278137002519 synthetase active site [active] 278137002520 NTP binding site [chemical binding]; other site 278137002521 metal binding site [ion binding]; metal-binding site 278137002522 adenylosuccinate lyase; Region: purB; TIGR00928 278137002523 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 278137002524 tetramer interface [polypeptide binding]; other site 278137002525 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 278137002526 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 278137002527 ATP binding site [chemical binding]; other site 278137002528 active site 278137002529 substrate binding site [chemical binding]; other site 278137002530 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 278137002531 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137002532 Helix-turn-helix domains; Region: HTH; cl00088 278137002533 WHG domain; Region: WHG; pfam13305 278137002534 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 278137002535 catalytic residues [active] 278137002536 dimer interface [polypeptide binding]; other site 278137002537 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 278137002538 Predicted deacetylase [General function prediction only]; Region: COG3233 278137002539 putative active site [active] 278137002540 putative Zn binding site [ion binding]; other site 278137002541 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 278137002542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137002543 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 278137002544 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 278137002545 putative active site [active] 278137002546 catalytic triad [active] 278137002547 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 278137002548 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 278137002549 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 278137002550 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 278137002551 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 278137002552 active site 278137002553 metal binding site [ion binding]; metal-binding site 278137002554 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278137002555 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 278137002556 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 278137002557 dimerization interface [polypeptide binding]; other site 278137002558 ATP binding site [chemical binding]; other site 278137002559 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 278137002560 dimerization interface [polypeptide binding]; other site 278137002561 ATP binding site [chemical binding]; other site 278137002562 Predicted membrane protein [Function unknown]; Region: COG4425 278137002563 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 278137002564 CAAX protease self-immunity; Region: Abi; cl00558 278137002565 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137002566 amidophosphoribosyltransferase; Provisional; Region: PRK07847 278137002567 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 278137002568 active site 278137002569 tetramer interface [polypeptide binding]; other site 278137002570 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137002571 active site 278137002572 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 278137002573 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 278137002574 putative NAD(P) binding site [chemical binding]; other site 278137002575 putative active site [active] 278137002576 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 278137002577 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 278137002578 dimerization interface [polypeptide binding]; other site 278137002579 putative ATP binding site [chemical binding]; other site 278137002580 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 278137002581 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 278137002582 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 278137002583 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 278137002584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137002585 catalytic residue [active] 278137002586 Helix-turn-helix domains; Region: HTH; cl00088 278137002587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137002588 Helix-turn-helix domains; Region: HTH; cl00088 278137002589 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 278137002590 heme-binding site [chemical binding]; other site 278137002591 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137002592 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 278137002593 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 278137002594 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 278137002595 active site residue [active] 278137002596 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 278137002597 active site residue [active] 278137002598 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 278137002599 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278137002600 catalytic residues [active] 278137002601 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 278137002602 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137002603 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137002604 DNA binding site [nucleotide binding] 278137002605 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 278137002606 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137002607 Coenzyme A binding pocket [chemical binding]; other site 278137002608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137002609 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 278137002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137002611 dimer interface [polypeptide binding]; other site 278137002612 conserved gate region; other site 278137002613 putative PBP binding loops; other site 278137002614 ABC-ATPase subunit interface; other site 278137002615 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 278137002616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137002617 dimer interface [polypeptide binding]; other site 278137002618 conserved gate region; other site 278137002619 putative PBP binding loops; other site 278137002620 ABC-ATPase subunit interface; other site 278137002621 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 278137002622 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 278137002623 Walker A/P-loop; other site 278137002624 ATP binding site [chemical binding]; other site 278137002625 Q-loop/lid; other site 278137002626 ABC transporter signature motif; other site 278137002627 Walker B; other site 278137002628 D-loop; other site 278137002629 H-loop/switch region; other site 278137002630 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 278137002631 PhoU domain; Region: PhoU; pfam01895 278137002632 PhoU domain; Region: PhoU; pfam01895 278137002633 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 278137002634 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 278137002635 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 278137002636 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 278137002637 FMN binding site [chemical binding]; other site 278137002638 active site 278137002639 catalytic residues [active] 278137002640 substrate binding site [chemical binding]; other site 278137002641 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 278137002642 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 278137002643 homodimer interface [polypeptide binding]; other site 278137002644 putative substrate binding pocket [chemical binding]; other site 278137002645 diiron center [ion binding]; other site 278137002646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137002647 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137002648 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 278137002649 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137002650 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137002651 active site 278137002652 ATP binding site [chemical binding]; other site 278137002653 substrate binding site [chemical binding]; other site 278137002654 activation loop (A-loop); other site 278137002655 Chorismate mutase type II; Region: CM_2; cl00693 278137002656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137002657 Helix-turn-helix domains; Region: HTH; cl00088 278137002658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137002659 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 278137002660 Helix-turn-helix domains; Region: HTH; cl00088 278137002661 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 278137002662 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 278137002663 putative hydrophobic ligand binding site [chemical binding]; other site 278137002664 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 278137002665 putative hydrophobic ligand binding site [chemical binding]; other site 278137002666 aminotransferase; Validated; Region: PRK07777 278137002667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278137002668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137002669 homodimer interface [polypeptide binding]; other site 278137002670 catalytic residue [active] 278137002671 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 278137002672 UreF; Region: UreF; pfam01730 278137002673 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 278137002674 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 278137002675 dimer interface [polypeptide binding]; other site 278137002676 catalytic residues [active] 278137002677 UreD urease accessory protein; Region: UreD; cl00530 278137002678 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137002679 urease subunit alpha; Reviewed; Region: ureC; PRK13308 278137002680 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 278137002681 subunit interactions [polypeptide binding]; other site 278137002682 active site 278137002683 flap region; other site 278137002684 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 278137002685 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 278137002686 alpha-gamma subunit interface [polypeptide binding]; other site 278137002687 beta-gamma subunit interface [polypeptide binding]; other site 278137002688 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 278137002689 gamma-beta subunit interface [polypeptide binding]; other site 278137002690 alpha-beta subunit interface [polypeptide binding]; other site 278137002691 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 278137002692 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 278137002693 putative ligand binding site [chemical binding]; other site 278137002694 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137002695 DNA binding residues [nucleotide binding] 278137002696 dimerization interface [polypeptide binding]; other site 278137002697 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 278137002698 FMN binding site [chemical binding]; other site 278137002699 active site 278137002700 substrate binding site [chemical binding]; other site 278137002701 catalytic residue [active] 278137002702 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 278137002703 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137002704 dimer interface [polypeptide binding]; other site 278137002705 active site 278137002706 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 278137002707 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137002708 substrate binding site [chemical binding]; other site 278137002709 oxyanion hole (OAH) forming residues; other site 278137002710 trimer interface [polypeptide binding]; other site 278137002711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002712 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 278137002713 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 278137002714 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 278137002715 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 278137002716 conserved cys residue [active] 278137002717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137002718 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 278137002719 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002720 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137002721 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137002722 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 278137002723 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 278137002724 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 278137002725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137002726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137002727 ATP binding site [chemical binding]; other site 278137002728 putative Mg++ binding site [ion binding]; other site 278137002729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137002730 nucleotide binding region [chemical binding]; other site 278137002731 ATP-binding site [chemical binding]; other site 278137002732 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 278137002733 WYL domain; Region: WYL; cl14852 278137002734 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 278137002735 trimer interface [polypeptide binding]; other site 278137002736 dimer interface [polypeptide binding]; other site 278137002737 putative active site [active] 278137002738 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 278137002739 MPT binding site; other site 278137002740 trimer interface [polypeptide binding]; other site 278137002741 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 278137002742 MoaE homodimer interface [polypeptide binding]; other site 278137002743 MoaD interaction [polypeptide binding]; other site 278137002744 active site residues [active] 278137002745 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278137002746 ydaO-yuaA element 278137002747 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 278137002748 MoaE interaction surface [polypeptide binding]; other site 278137002749 MoeB interaction surface [polypeptide binding]; other site 278137002750 thiocarboxylated glycine; other site 278137002751 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 278137002752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137002753 FeS/SAM binding site; other site 278137002754 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 278137002755 hypothetical protein; Provisional; Region: PRK11770 278137002756 Domain of unknown function (DUF307); Region: DUF307; pfam03733 278137002757 Domain of unknown function (DUF307); Region: DUF307; pfam03733 278137002758 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 278137002759 DNA-binding site [nucleotide binding]; DNA binding site 278137002760 RNA-binding motif; other site 278137002761 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 278137002762 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 278137002763 putative dimer interface [polypeptide binding]; other site 278137002764 N-terminal domain interface [polypeptide binding]; other site 278137002765 putative substrate binding pocket (H-site) [chemical binding]; other site 278137002766 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 278137002767 H+ Antiporter protein; Region: 2A0121; TIGR00900 278137002768 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 278137002769 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 278137002770 hydrophobic ligand binding site; other site 278137002771 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 278137002772 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 278137002773 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 278137002774 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 278137002775 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 278137002776 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137002777 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 278137002778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137002779 catalytic residue [active] 278137002780 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 278137002781 Ferredoxin [Energy production and conversion]; Region: COG1146 278137002782 4Fe-4S binding domain; Region: Fer4; cl02805 278137002783 ferredoxin-NADP+ reductase; Region: PLN02852 278137002784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002785 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 278137002786 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278137002787 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 278137002788 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137002789 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 278137002790 putative dimer interface [polypeptide binding]; other site 278137002791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137002792 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137002793 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 278137002794 Citrate synthase; Region: Citrate_synt; pfam00285 278137002795 oxalacetate binding site [chemical binding]; other site 278137002796 citrylCoA binding site [chemical binding]; other site 278137002797 coenzyme A binding site [chemical binding]; other site 278137002798 catalytic triad [active] 278137002799 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 278137002800 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137002801 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 278137002802 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 278137002803 Helix-turn-helix domains; Region: HTH; cl00088 278137002804 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 278137002805 dimer interface [polypeptide binding]; other site 278137002806 Citrate synthase; Region: Citrate_synt; pfam00285 278137002807 active site 278137002808 citrylCoA binding site [chemical binding]; other site 278137002809 NADH binding [chemical binding]; other site 278137002810 cationic pore residues; other site 278137002811 oxalacetate/citrate binding site [chemical binding]; other site 278137002812 coenzyme A binding site [chemical binding]; other site 278137002813 catalytic triad [active] 278137002814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278137002815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137002816 putative substrate translocation pore; other site 278137002817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137002818 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278137002819 Helix-turn-helix domains; Region: HTH; cl00088 278137002820 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 278137002821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002822 MspA; Region: MspA; pfam09203 278137002823 MspA; Region: MspA; pfam09203 278137002824 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137002825 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137002826 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 278137002827 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 278137002828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 278137002829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137002830 dimer interface [polypeptide binding]; other site 278137002831 phosphorylation site [posttranslational modification] 278137002832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137002833 ATP binding site [chemical binding]; other site 278137002834 Mg2+ binding site [ion binding]; other site 278137002835 G-X-G motif; other site 278137002836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137002837 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137002838 active site 278137002839 phosphorylation site [posttranslational modification] 278137002840 intermolecular recognition site; other site 278137002841 dimerization interface [polypeptide binding]; other site 278137002842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137002843 DNA binding site [nucleotide binding] 278137002844 Ion channel; Region: Ion_trans_2; cl11596 278137002845 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278137002846 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278137002847 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137002848 Walker A/P-loop; other site 278137002849 ATP binding site [chemical binding]; other site 278137002850 Q-loop/lid; other site 278137002851 ABC transporter signature motif; other site 278137002852 Walker B; other site 278137002853 D-loop; other site 278137002854 H-loop/switch region; other site 278137002855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278137002856 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278137002857 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137002858 Walker A/P-loop; other site 278137002859 ATP binding site [chemical binding]; other site 278137002860 Q-loop/lid; other site 278137002861 ABC transporter signature motif; other site 278137002862 Walker B; other site 278137002863 D-loop; other site 278137002864 H-loop/switch region; other site 278137002865 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278137002866 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278137002867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137002868 Walker A/P-loop; other site 278137002869 ATP binding site [chemical binding]; other site 278137002870 Q-loop/lid; other site 278137002871 ABC transporter signature motif; other site 278137002872 Walker B; other site 278137002873 D-loop; other site 278137002874 H-loop/switch region; other site 278137002875 Epoxide hydrolase N terminus; Region: EHN; pfam06441 278137002876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137002877 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 278137002878 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137002879 Walker A/P-loop; other site 278137002880 ATP binding site [chemical binding]; other site 278137002881 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 278137002882 Predicted membrane protein [Function unknown]; Region: COG1511 278137002883 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137002884 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 278137002885 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137002886 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137002887 enoyl-CoA hydratase; Provisional; Region: PRK06688 278137002888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137002889 substrate binding site [chemical binding]; other site 278137002890 oxyanion hole (OAH) forming residues; other site 278137002891 trimer interface [polypeptide binding]; other site 278137002892 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137002893 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137002894 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 278137002895 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 278137002896 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137002897 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137002898 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137002899 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 278137002900 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 278137002901 hydrophobic ligand binding site; other site 278137002902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002903 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278137002904 NAD(P) binding site [chemical binding]; other site 278137002905 active site 278137002906 ERG2 and Sigma1 receptor like protein; Region: ERG2_Sigma1R; pfam04622 278137002907 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002908 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002909 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278137002910 active site 278137002911 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137002912 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137002913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002914 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137002915 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 278137002916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137002917 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 278137002918 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137002919 metal ion-dependent adhesion site (MIDAS); other site 278137002920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137002921 Helix-turn-helix domains; Region: HTH; cl00088 278137002922 short chain dehydrogenase; Provisional; Region: PRK07814 278137002923 classical (c) SDRs; Region: SDR_c; cd05233 278137002924 NAD(P) binding site [chemical binding]; other site 278137002925 active site 278137002926 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137002927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002928 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 278137002929 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137002930 molybdopterin cofactor binding site; other site 278137002931 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 278137002932 molybdopterin cofactor binding site; other site 278137002933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137002934 metal binding site [ion binding]; metal-binding site 278137002935 active site 278137002936 I-site; other site 278137002937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137002938 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 278137002939 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002940 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137002941 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 278137002942 classical (c) SDRs; Region: SDR_c; cd05233 278137002943 NAD(P) binding site [chemical binding]; other site 278137002944 active site 278137002945 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 278137002946 AMP-binding enzyme; Region: AMP-binding; cl15778 278137002947 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137002948 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278137002949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137002950 DNA-binding site [nucleotide binding]; DNA binding site 278137002951 UTRA domain; Region: UTRA; cl01230 278137002952 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 278137002953 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 278137002954 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 278137002955 classical (c) SDRs; Region: SDR_c; cd05233 278137002956 NAD(P) binding site [chemical binding]; other site 278137002957 active site 278137002958 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 278137002959 [2Fe-2S] cluster binding site [ion binding]; other site 278137002960 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 278137002961 putative alpha subunit interface [polypeptide binding]; other site 278137002962 putative active site [active] 278137002963 putative substrate binding site [chemical binding]; other site 278137002964 Fe binding site [ion binding]; other site 278137002965 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137002966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137002967 NAD(P) binding site [chemical binding]; other site 278137002968 active site 278137002969 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137002970 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137002971 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 278137002972 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002973 active site 278137002974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002975 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002976 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 278137002977 active site 278137002978 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137002979 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137002980 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137002981 active site 278137002982 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 278137002983 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 278137002984 PYR/PP interface [polypeptide binding]; other site 278137002985 dimer interface [polypeptide binding]; other site 278137002986 TPP binding site [chemical binding]; other site 278137002987 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 278137002988 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 278137002989 TPP-binding site; other site 278137002990 dimer interface [polypeptide binding]; other site 278137002991 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 278137002992 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137002993 NAD binding site [chemical binding]; other site 278137002994 catalytic residues [active] 278137002995 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 278137002996 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 278137002997 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 278137002998 dimer interface [polypeptide binding]; other site 278137002999 active site 278137003000 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 278137003001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137003002 S-adenosylmethionine binding site [chemical binding]; other site 278137003003 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 278137003004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137003005 S-adenosylmethionine binding site [chemical binding]; other site 278137003006 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 278137003007 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 278137003008 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 278137003009 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 278137003010 putative dimer interface [polypeptide binding]; other site 278137003011 Helix-turn-helix domains; Region: HTH; cl00088 278137003012 Helix-turn-helix domains; Region: HTH; cl00088 278137003013 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 278137003014 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 278137003015 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 278137003016 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137003017 active site 278137003018 GAF domain; Region: GAF_2; pfam13185 278137003019 ANTAR domain; Region: ANTAR; cl04297 278137003020 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278137003021 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 278137003022 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 278137003023 nucleotide binding site [chemical binding]; other site 278137003024 polymerase nucleotide-binding site; other site 278137003025 primase nucleotide-binding site [nucleotide binding]; other site 278137003026 DNA-binding residues [nucleotide binding]; DNA binding site 278137003027 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278137003028 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278137003029 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137003030 active site 278137003031 DNA binding site [nucleotide binding] 278137003032 Int/Topo IB signature motif; other site 278137003033 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 278137003034 Subunit I/III interface [polypeptide binding]; other site 278137003035 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 278137003036 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137003037 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 278137003038 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 278137003039 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 278137003040 Helix-turn-helix domains; Region: HTH; cl00088 278137003041 Integrase core domain; Region: rve; cl01316 278137003042 Anti-sigma-K factor rskA; Region: RskA; pfam10099 278137003043 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 278137003044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137003045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137003046 DNA binding residues [nucleotide binding] 278137003047 Uncharacterized conserved protein [Function unknown]; Region: COG3496 278137003048 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 278137003049 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 278137003050 putative active site pocket [active] 278137003051 dimerization interface [polypeptide binding]; other site 278137003052 putative catalytic residue [active] 278137003053 Protein of unknown function (DUF867); Region: DUF867; cl01713 278137003054 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 278137003055 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 278137003056 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137003057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003058 short chain dehydrogenase; Provisional; Region: PRK07814 278137003059 classical (c) SDRs; Region: SDR_c; cd05233 278137003060 NAD(P) binding site [chemical binding]; other site 278137003061 active site 278137003062 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 278137003063 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 278137003064 putative DNA binding site [nucleotide binding]; other site 278137003065 putative homodimer interface [polypeptide binding]; other site 278137003066 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 278137003067 putative substrate binding site [chemical binding]; other site 278137003068 putative ATP binding site [chemical binding]; other site 278137003069 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 278137003070 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 278137003071 nucleotide binding site [chemical binding]; other site 278137003072 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 278137003073 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 278137003074 active site 278137003075 DNA binding site [nucleotide binding] 278137003076 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 278137003077 DNA binding site [nucleotide binding] 278137003078 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137003079 classical (c) SDRs; Region: SDR_c; cd05233 278137003080 NAD(P) binding site [chemical binding]; other site 278137003081 active site 278137003082 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 278137003083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003084 NAD(P) binding site [chemical binding]; other site 278137003085 active site 278137003086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278137003087 Helix-turn-helix domains; Region: HTH; cl00088 278137003088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137003089 dimerization interface [polypeptide binding]; other site 278137003090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 278137003091 Transposase; Region: DDE_Tnp_ISL3; pfam01610 278137003092 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137003093 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137003094 active site 278137003095 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 278137003096 RNA/DNA hybrid binding site [nucleotide binding]; other site 278137003097 active site 278137003098 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278137003099 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137003100 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137003101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137003102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278137003103 putative substrate translocation pore; other site 278137003104 Helix-turn-helix domains; Region: HTH; cl00088 278137003105 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278137003106 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278137003107 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 278137003108 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 278137003109 active site 278137003110 metal binding site [ion binding]; metal-binding site 278137003111 nudix motif; other site 278137003112 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137003113 [2Fe-2S] cluster binding site [ion binding]; other site 278137003114 iron-sulfur cluster [ion binding]; other site 278137003115 Uncharacterized conserved protein [Function unknown]; Region: COG3349 278137003116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003117 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 278137003118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137003119 S-adenosylmethionine binding site [chemical binding]; other site 278137003120 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 278137003121 active site lid residues [active] 278137003122 substrate binding pocket [chemical binding]; other site 278137003123 catalytic residues [active] 278137003124 substrate-Mg2+ binding site; other site 278137003125 aspartate-rich region 1; other site 278137003126 aspartate-rich region 2; other site 278137003127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003128 phytoene desaturase; Region: crtI_fam; TIGR02734 278137003129 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 278137003130 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 278137003131 substrate binding pocket [chemical binding]; other site 278137003132 chain length determination region; other site 278137003133 substrate-Mg2+ binding site; other site 278137003134 catalytic residues [active] 278137003135 aspartate-rich region 1; other site 278137003136 active site lid residues [active] 278137003137 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 278137003138 aspartate-rich region 2; other site 278137003139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278137003140 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137003141 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 278137003142 Membrane protein of unknown function; Region: DUF360; cl00850 278137003143 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 278137003144 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 278137003145 putative DNA binding site [nucleotide binding]; other site 278137003146 catalytic residue [active] 278137003147 putative H2TH interface [polypeptide binding]; other site 278137003148 putative catalytic residues [active] 278137003149 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 278137003150 short chain dehydrogenase; Provisional; Region: PRK08251 278137003151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003152 NAD(P) binding site [chemical binding]; other site 278137003153 active site 278137003154 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137003155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137003156 non-specific DNA binding site [nucleotide binding]; other site 278137003157 salt bridge; other site 278137003158 sequence-specific DNA binding site [nucleotide binding]; other site 278137003159 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 278137003160 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 278137003161 active site 278137003162 dimer interface [polypeptide binding]; other site 278137003163 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 278137003164 dimer interface [polypeptide binding]; other site 278137003165 active site 278137003166 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137003167 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 278137003168 tetramerization interface [polypeptide binding]; other site 278137003169 NAD(P) binding site [chemical binding]; other site 278137003170 catalytic residues [active] 278137003171 OpgC protein; Region: OpgC_C; cl00792 278137003172 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 278137003173 active site 278137003174 catalytic triad [active] 278137003175 oxyanion hole [active] 278137003176 Chorismate mutase type II; Region: CM_2; cl00693 278137003177 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 278137003178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137003179 Family description; Region: UvrD_C_2; cl15862 278137003180 Peptidase family M23; Region: Peptidase_M23; pfam01551 278137003181 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 278137003182 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137003183 CoA-ligase; Region: Ligase_CoA; cl02894 278137003184 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 278137003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003186 CoA-ligase; Region: Ligase_CoA; cl02894 278137003187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137003188 Archaeal ATPase; Region: Arch_ATPase; pfam01637 278137003189 Walker A motif; other site 278137003190 ATP binding site [chemical binding]; other site 278137003191 Helix-turn-helix domains; Region: HTH; cl00088 278137003192 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 278137003193 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137003194 active site 278137003195 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 278137003196 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137003197 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 278137003198 active site 278137003199 cosubstrate binding site; other site 278137003200 substrate binding site [chemical binding]; other site 278137003201 catalytic site [active] 278137003202 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 278137003203 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 278137003204 purine monophosphate binding site [chemical binding]; other site 278137003205 dimer interface [polypeptide binding]; other site 278137003206 putative catalytic residues [active] 278137003207 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 278137003208 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 278137003209 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 278137003210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137003211 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 278137003212 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137003213 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 278137003214 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 278137003215 enoyl-CoA hydratase; Provisional; Region: PRK07827 278137003216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137003217 substrate binding site [chemical binding]; other site 278137003218 oxyanion hole (OAH) forming residues; other site 278137003219 trimer interface [polypeptide binding]; other site 278137003220 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137003221 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 278137003222 active site 278137003223 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 278137003224 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278137003225 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137003226 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 278137003227 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278137003228 carboxyltransferase (CT) interaction site; other site 278137003229 biotinylation site [posttranslational modification]; other site 278137003230 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 278137003231 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137003232 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137003233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137003234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137003235 active site 278137003236 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 278137003237 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137003238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137003239 active site 278137003240 phosphorylation site [posttranslational modification] 278137003241 intermolecular recognition site; other site 278137003242 dimerization interface [polypeptide binding]; other site 278137003243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137003244 DNA binding site [nucleotide binding] 278137003245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278137003246 dimerization interface [polypeptide binding]; other site 278137003247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137003248 dimer interface [polypeptide binding]; other site 278137003249 phosphorylation site [posttranslational modification] 278137003250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137003251 ATP binding site [chemical binding]; other site 278137003252 Mg2+ binding site [ion binding]; other site 278137003253 G-X-G motif; other site 278137003254 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 278137003255 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 278137003256 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 278137003257 MPT binding site; other site 278137003258 trimer interface [polypeptide binding]; other site 278137003259 MspA; Region: MspA; pfam09203 278137003260 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 278137003261 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 278137003262 SAF domain; Region: SAF; cl00555 278137003263 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 278137003264 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 278137003265 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137003266 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 278137003267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137003268 active site 278137003269 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 278137003270 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 278137003271 dimer interface [polypeptide binding]; other site 278137003272 putative functional site; other site 278137003273 putative MPT binding site; other site 278137003274 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137003275 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 278137003276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137003277 dimerization interface [polypeptide binding]; other site 278137003278 putative DNA binding site [nucleotide binding]; other site 278137003279 putative Zn2+ binding site [ion binding]; other site 278137003280 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 278137003281 Cation efflux family; Region: Cation_efflux; cl00316 278137003282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137003283 short chain dehydrogenase; Provisional; Region: PRK12827 278137003284 classical (c) SDRs; Region: SDR_c; cd05233 278137003285 NAD(P) binding site [chemical binding]; other site 278137003286 active site 278137003287 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137003288 classical (c) SDRs; Region: SDR_c; cd05233 278137003289 NAD(P) binding site [chemical binding]; other site 278137003290 active site 278137003291 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137003292 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137003293 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 278137003294 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137003295 NAD(P) binding site [chemical binding]; other site 278137003296 catalytic residues [active] 278137003297 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137003298 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 278137003299 Helix-turn-helix domains; Region: HTH; cl00088 278137003300 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 278137003301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003302 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137003303 Cupin domain; Region: Cupin_2; cl09118 278137003304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137003305 metal binding site [ion binding]; metal-binding site 278137003306 active site 278137003307 I-site; other site 278137003308 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 278137003309 ligand binding site [chemical binding]; other site 278137003310 flexible hinge region; other site 278137003311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278137003312 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137003313 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 278137003314 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 278137003315 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 278137003316 shikimate binding site; other site 278137003317 NAD(P) binding site [chemical binding]; other site 278137003318 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 278137003319 PE-PPE domain; Region: PE-PPE; pfam08237 278137003320 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 278137003321 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 278137003322 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 278137003323 DNA binding residues [nucleotide binding] 278137003324 dimer interface [polypeptide binding]; other site 278137003325 [2Fe-2S] cluster binding site [ion binding]; other site 278137003326 Amidinotransferase; Region: Amidinotransf; cl12043 278137003327 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 278137003328 Helix-turn-helix domains; Region: HTH; cl00088 278137003329 Integrase core domain; Region: rve; cl01316 278137003330 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 278137003331 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 278137003332 Predicted methyltransferases [General function prediction only]; Region: COG0313 278137003333 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278137003334 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 278137003335 chorismate binding enzyme; Region: Chorismate_bind; cl10555 278137003336 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 278137003337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137003338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137003339 DNA binding residues [nucleotide binding] 278137003340 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137003341 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 278137003342 glutamate dehydrogenase; Provisional; Region: PRK09414 278137003343 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 278137003344 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 278137003345 NAD(P) binding site [chemical binding]; other site 278137003346 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 278137003347 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 278137003348 active site 278137003349 HIGH motif; other site 278137003350 KMSKS motif; other site 278137003351 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 278137003352 tRNA binding surface [nucleotide binding]; other site 278137003353 anticodon binding site; other site 278137003354 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 278137003355 active site 278137003356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 278137003357 Domain of unknown function (DUF348); Region: DUF348; pfam03990 278137003358 Domain of unknown function (DUF348); Region: DUF348; pfam03990 278137003359 Domain of unknown function (DUF348); Region: DUF348; pfam03990 278137003360 G5 domain; Region: G5; pfam07501 278137003361 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278137003362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137003363 S-adenosylmethionine binding site [chemical binding]; other site 278137003364 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 278137003365 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 278137003366 AMP-binding enzyme; Region: AMP-binding; cl15778 278137003367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137003368 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 278137003369 Walker A/P-loop; other site 278137003370 ATP binding site [chemical binding]; other site 278137003371 Q-loop/lid; other site 278137003372 ABC transporter signature motif; other site 278137003373 Walker B; other site 278137003374 D-loop; other site 278137003375 H-loop/switch region; other site 278137003376 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137003377 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 278137003378 putative active site [active] 278137003379 catalytic residue [active] 278137003380 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 278137003381 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 278137003382 5S rRNA interface [nucleotide binding]; other site 278137003383 CTC domain interface [polypeptide binding]; other site 278137003384 L16 interface [polypeptide binding]; other site 278137003385 short chain dehydrogenase; Provisional; Region: PRK06197 278137003386 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 278137003387 putative NAD(P) binding site [chemical binding]; other site 278137003388 active site 278137003389 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 278137003390 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 278137003391 ArsC family; Region: ArsC; pfam03960 278137003392 catalytic residues [active] 278137003393 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 278137003394 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 278137003395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137003396 active site 278137003397 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 278137003398 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 278137003399 Substrate binding site; other site 278137003400 Mg++ binding site; other site 278137003401 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 278137003402 active site 278137003403 substrate binding site [chemical binding]; other site 278137003404 CoA binding site [chemical binding]; other site 278137003405 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 278137003406 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 278137003407 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 278137003408 Helix-turn-helix domains; Region: HTH; cl00088 278137003409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137003410 Helix-turn-helix domains; Region: HTH; cl00088 278137003411 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 278137003412 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 278137003413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137003414 ATP binding site [chemical binding]; other site 278137003415 putative Mg++ binding site [ion binding]; other site 278137003416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137003417 nucleotide binding region [chemical binding]; other site 278137003418 ATP-binding site [chemical binding]; other site 278137003419 TRCF domain; Region: TRCF; cl04088 278137003420 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 278137003421 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 278137003422 homodimer interface [polypeptide binding]; other site 278137003423 metal binding site [ion binding]; metal-binding site 278137003424 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 278137003425 Imelysin; Region: Peptidase_M75; cl09159 278137003426 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 278137003427 enolase; Provisional; Region: eno; PRK00077 278137003428 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 278137003429 dimer interface [polypeptide binding]; other site 278137003430 metal binding site [ion binding]; metal-binding site 278137003431 substrate binding pocket [chemical binding]; other site 278137003432 Septum formation initiator; Region: DivIC; cl11433 278137003433 Protein of unknown function (DUF501); Region: DUF501; cl00652 278137003434 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 278137003435 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 278137003436 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 278137003437 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 278137003438 AMP-binding enzyme; Region: AMP-binding; cl15778 278137003439 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137003440 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137003441 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 278137003442 oxidoreductase; Provisional; Region: PRK06128 278137003443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003444 NAD(P) binding site [chemical binding]; other site 278137003445 active site 278137003446 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 278137003447 Flavin Reductases; Region: FlaRed; cl00801 278137003448 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 278137003449 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137003450 NAD binding site [chemical binding]; other site 278137003451 catalytic Zn binding site [ion binding]; other site 278137003452 structural Zn binding site [ion binding]; other site 278137003453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137003454 active site 278137003455 DNA binding site [nucleotide binding] 278137003456 Int/Topo IB signature motif; other site 278137003457 transcription termination factor Rho; Provisional; Region: PRK12678 278137003458 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278137003459 Helix-turn-helix domains; Region: HTH; cl00088 278137003460 putative transposase OrfB; Reviewed; Region: PHA02517 278137003461 HTH-like domain; Region: HTH_21; pfam13276 278137003462 Integrase core domain; Region: rve; cl01316 278137003463 Integrase core domain; Region: rve_3; cl15866 278137003464 Helix-turn-helix domains; Region: HTH; cl00088 278137003465 HTH-like domain; Region: HTH_21; pfam13276 278137003466 Integrase core domain; Region: rve; cl01316 278137003467 Integrase core domain; Region: rve_3; cl15866 278137003468 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 278137003469 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 278137003470 metal binding site [ion binding]; metal-binding site 278137003471 putative dimer interface [polypeptide binding]; other site 278137003472 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 278137003473 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278137003474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137003475 non-specific DNA binding site [nucleotide binding]; other site 278137003476 salt bridge; other site 278137003477 sequence-specific DNA binding site [nucleotide binding]; other site 278137003478 Domain of unknown function (DUF955); Region: DUF955; cl01076 278137003479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 278137003480 Helix-turn-helix domains; Region: HTH; cl00088 278137003481 Integrase core domain; Region: rve; cl01316 278137003482 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 278137003483 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278137003484 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137003485 active site 278137003486 DNA binding site [nucleotide binding] 278137003487 Int/Topo IB signature motif; other site 278137003488 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137003489 active site 278137003490 DNA binding site [nucleotide binding] 278137003491 Int/Topo IB signature motif; other site 278137003492 Peptidase family M48; Region: Peptidase_M48; cl12018 278137003493 Transport protein; Region: actII; TIGR00833 278137003494 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 278137003495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137003496 Helix-turn-helix domains; Region: HTH; cl00088 278137003497 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 278137003498 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 278137003499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137003500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137003501 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137003502 CoenzymeA binding site [chemical binding]; other site 278137003503 subunit interaction site [polypeptide binding]; other site 278137003504 PHB binding site; other site 278137003505 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137003506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137003507 Helix-turn-helix domains; Region: HTH; cl00088 278137003508 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 278137003509 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137003510 Helix-turn-helix domains; Region: HTH; cl00088 278137003511 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137003512 CoenzymeA binding site [chemical binding]; other site 278137003513 subunit interaction site [polypeptide binding]; other site 278137003514 PHB binding site; other site 278137003515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137003516 Helix-turn-helix domains; Region: HTH; cl00088 278137003517 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278137003518 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278137003519 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 278137003520 Int/Topo IB signature motif; other site 278137003521 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137003522 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137003523 active site 278137003524 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 278137003525 E-class dimer interface [polypeptide binding]; other site 278137003526 P-class dimer interface [polypeptide binding]; other site 278137003527 active site 278137003528 Cu2+ binding site [ion binding]; other site 278137003529 Zn2+ binding site [ion binding]; other site 278137003530 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137003531 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137003532 acyl-CoA synthetase; Validated; Region: PRK07788 278137003533 AMP-binding enzyme; Region: AMP-binding; cl15778 278137003534 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137003535 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137003536 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 278137003537 cyanate hydratase; Validated; Region: PRK02866 278137003538 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 278137003539 oligomer interface [polypeptide binding]; other site 278137003540 active site 278137003541 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 278137003542 Spore germination protein; Region: Spore_permease; cl15802 278137003543 Spore germination protein; Region: Spore_permease; cl15802 278137003544 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 278137003545 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 278137003546 Secretory lipase; Region: LIP; pfam03583 278137003547 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137003548 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137003549 classical (c) SDRs; Region: SDR_c; cd05233 278137003550 NAD(P) binding site [chemical binding]; other site 278137003551 active site 278137003552 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 278137003553 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 278137003554 putative active site [active] 278137003555 putative dimer interface [polypeptide binding]; other site 278137003556 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 278137003557 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137003558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137003559 Coenzyme A binding pocket [chemical binding]; other site 278137003560 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 278137003561 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 278137003562 Cl- selectivity filter; other site 278137003563 Cl- binding residues [ion binding]; other site 278137003564 pore gating glutamate residue; other site 278137003565 dimer interface [polypeptide binding]; other site 278137003566 H+/Cl- coupling transport residue; other site 278137003567 Interferon-induced transmembrane protein; Region: CD225; pfam04505 278137003568 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 278137003569 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137003570 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 278137003571 yybP-ykoY element 278137003572 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 278137003573 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 278137003574 putative transporter; Provisional; Region: PRK10504 278137003575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137003576 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137003577 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137003578 anti sigma factor interaction site; other site 278137003579 regulatory phosphorylation site [posttranslational modification]; other site 278137003580 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137003581 anti sigma factor interaction site; other site 278137003582 regulatory phosphorylation site [posttranslational modification]; other site 278137003583 lipid-transfer protein; Provisional; Region: PRK08256 278137003584 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137003585 active site 278137003586 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137003587 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137003588 active site 278137003589 ATP binding site [chemical binding]; other site 278137003590 substrate binding site [chemical binding]; other site 278137003591 activation loop (A-loop); other site 278137003592 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137003593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003594 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137003595 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 278137003596 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 278137003597 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 278137003598 active site 278137003599 nucleophile elbow; other site 278137003600 hypothetical protein; Provisional; Region: PRK10279 278137003601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137003602 dimerization interface [polypeptide binding]; other site 278137003603 putative DNA binding site [nucleotide binding]; other site 278137003604 putative Zn2+ binding site [ion binding]; other site 278137003605 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 278137003606 putative hydrophobic ligand binding site [chemical binding]; other site 278137003607 Cysteine dioxygenase type I; Region: CDO_I; cl15835 278137003608 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 278137003609 active site residue [active] 278137003610 Predicted membrane protein [Function unknown]; Region: COG4425 278137003611 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 278137003612 enoyl-CoA hydratase; Provisional; Region: PRK05862 278137003613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137003614 substrate binding site [chemical binding]; other site 278137003615 oxyanion hole (OAH) forming residues; other site 278137003616 trimer interface [polypeptide binding]; other site 278137003617 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 278137003618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137003619 substrate binding site [chemical binding]; other site 278137003620 oxyanion hole (OAH) forming residues; other site 278137003621 trimer interface [polypeptide binding]; other site 278137003622 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 278137003623 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 278137003624 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 278137003625 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 278137003626 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137003627 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 278137003628 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137003629 dimer interface [polypeptide binding]; other site 278137003630 active site 278137003631 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 278137003632 active site 278137003633 catalytic triad [active] 278137003634 oxyanion hole [active] 278137003635 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137003636 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137003637 substrate binding pocket [chemical binding]; other site 278137003638 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 278137003639 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 278137003640 dimer interface [polypeptide binding]; other site 278137003641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137003642 catalytic residue [active] 278137003643 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 278137003644 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 278137003645 RDD family; Region: RDD; cl00746 278137003646 cystathionine gamma-synthase; Provisional; Region: PRK07811 278137003647 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 278137003648 homodimer interface [polypeptide binding]; other site 278137003649 substrate-cofactor binding pocket; other site 278137003650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137003651 catalytic residue [active] 278137003652 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 278137003653 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 278137003654 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 278137003655 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 278137003656 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 278137003657 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 278137003658 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137003659 Haemolysin-III related; Region: HlyIII; cl03831 278137003660 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 278137003661 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 278137003662 catalytic residue [active] 278137003663 putative FPP diphosphate binding site; other site 278137003664 putative FPP binding hydrophobic cleft; other site 278137003665 dimer interface [polypeptide binding]; other site 278137003666 putative IPP diphosphate binding site; other site 278137003667 pantothenate kinase; Provisional; Region: PRK05439 278137003668 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 278137003669 ATP-binding site [chemical binding]; other site 278137003670 CoA-binding site [chemical binding]; other site 278137003671 Mg2+-binding site [ion binding]; other site 278137003672 serine hydroxymethyltransferase; Provisional; Region: PRK13580 278137003673 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 278137003674 dimer interface [polypeptide binding]; other site 278137003675 active site 278137003676 glycine-pyridoxal phosphate binding site [chemical binding]; other site 278137003677 folate binding site [chemical binding]; other site 278137003678 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 278137003679 dinuclear metal binding motif [ion binding]; other site 278137003680 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 278137003681 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 278137003682 putative active site [active] 278137003683 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137003684 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 278137003685 fumarate hydratase; Reviewed; Region: fumC; PRK00485 278137003686 Class II fumarases; Region: Fumarase_classII; cd01362 278137003687 active site 278137003688 tetramer interface [polypeptide binding]; other site 278137003689 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 278137003690 putative active site [active] 278137003691 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 278137003692 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 278137003693 Domain of unknown function DUF20; Region: UPF0118; pfam01594 278137003694 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 278137003695 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137003696 classical (c) SDRs; Region: SDR_c; cd05233 278137003697 NAD(P) binding site [chemical binding]; other site 278137003698 active site 278137003699 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 278137003700 hydrophobic ligand binding site; other site 278137003701 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137003702 metal binding site [ion binding]; metal-binding site 278137003703 active site 278137003704 I-site; other site 278137003705 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137003706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137003707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003708 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 278137003709 NAD(P) binding site [chemical binding]; other site 278137003710 active site 278137003711 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 278137003712 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 278137003713 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 278137003714 generic binding surface II; other site 278137003715 generic binding surface I; other site 278137003716 LytB protein; Region: LYTB; cl00507 278137003717 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 278137003718 GTP-binding protein YchF; Reviewed; Region: PRK09601 278137003719 YchF GTPase; Region: YchF; cd01900 278137003720 G1 box; other site 278137003721 GTP/Mg2+ binding site [chemical binding]; other site 278137003722 Switch I region; other site 278137003723 G2 box; other site 278137003724 Switch II region; other site 278137003725 G3 box; other site 278137003726 G4 box; other site 278137003727 G5 box; other site 278137003728 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 278137003729 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 278137003730 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 278137003731 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 278137003732 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137003733 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 278137003734 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137003735 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 278137003736 cyclase homology domain; Region: CHD; cd07302 278137003737 nucleotidyl binding site; other site 278137003738 metal binding site [ion binding]; metal-binding site 278137003739 dimer interface [polypeptide binding]; other site 278137003740 Transposase domain (DUF772); Region: DUF772; pfam05598 278137003741 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137003742 DDE superfamily endonuclease; Region: DDE_4; cl15789 278137003743 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137003744 hypothetical protein; Provisional; Region: PRK06149 278137003745 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137003746 active site 278137003747 ATP binding site [chemical binding]; other site 278137003748 substrate binding site [chemical binding]; other site 278137003749 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137003750 inhibitor-cofactor binding pocket; inhibition site 278137003751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137003752 catalytic residue [active] 278137003753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137003754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137003755 Helix-turn-helix domains; Region: HTH; cl00088 278137003756 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 278137003757 dimer interface [polypeptide binding]; other site 278137003758 Permease; Region: Permease; cl00510 278137003759 Permease; Region: Permease; cl00510 278137003760 mce related protein; Region: MCE; pfam02470 278137003761 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137003762 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137003763 mce related protein; Region: MCE; pfam02470 278137003764 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137003765 mce related protein; Region: MCE; pfam02470 278137003766 mce related protein; Region: MCE; pfam02470 278137003767 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137003768 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137003769 mce related protein; Region: MCE; pfam02470 278137003770 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137003771 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137003772 mce related protein; Region: MCE; pfam02470 278137003773 Helix-turn-helix domains; Region: HTH; cl00088 278137003774 WHG domain; Region: WHG; pfam13305 278137003775 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 278137003776 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 278137003777 DoxX; Region: DoxX; cl00976 278137003778 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 278137003779 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 278137003780 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137003781 Transcriptional regulators [Transcription]; Region: FadR; COG2186 278137003782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137003783 FCD domain; Region: FCD; cl11656 278137003784 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 278137003785 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137003786 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 278137003787 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137003788 dimer interface [polypeptide binding]; other site 278137003789 active site 278137003790 enoyl-CoA hydratase; Provisional; Region: PRK08252 278137003791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137003792 substrate binding site [chemical binding]; other site 278137003793 oxyanion hole (OAH) forming residues; other site 278137003794 trimer interface [polypeptide binding]; other site 278137003795 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137003796 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137003797 active site 278137003798 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 278137003799 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137003800 Fasciclin domain; Region: Fasciclin; cl02663 278137003801 oxidoreductase; Provisional; Region: PRK06196 278137003802 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 278137003803 putative NAD(P) binding site [chemical binding]; other site 278137003804 active site 278137003805 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 278137003806 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 278137003807 trimer interface [polypeptide binding]; other site 278137003808 putative metal binding site [ion binding]; other site 278137003809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137003810 NAD(P) binding site [chemical binding]; other site 278137003811 active site 278137003812 CAAX protease self-immunity; Region: Abi; cl00558 278137003813 enoyl-CoA hydratase; Provisional; Region: PRK06688 278137003814 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137003815 substrate binding site [chemical binding]; other site 278137003816 oxyanion hole (OAH) forming residues; other site 278137003817 trimer interface [polypeptide binding]; other site 278137003818 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137003819 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137003820 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 278137003821 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 278137003822 NAD binding site [chemical binding]; other site 278137003823 homodimer interface [polypeptide binding]; other site 278137003824 homotetramer interface [polypeptide binding]; other site 278137003825 active site 278137003826 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 278137003827 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137003828 FMN binding site [chemical binding]; other site 278137003829 substrate binding site [chemical binding]; other site 278137003830 putative catalytic residue [active] 278137003831 DoxX; Region: DoxX; cl00976 278137003832 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137003833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137003834 Helix-turn-helix domains; Region: HTH; cl00088 278137003835 WHG domain; Region: WHG; pfam13305 278137003836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137003837 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 278137003838 NAD+ binding site [chemical binding]; other site 278137003839 substrate binding site [chemical binding]; other site 278137003840 Zn binding site [ion binding]; other site 278137003841 Predicted transcriptional regulators [Transcription]; Region: COG1725 278137003842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137003843 DNA-binding site [nucleotide binding]; DNA binding site 278137003844 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137003845 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137003846 Integrase core domain; Region: rve; cl01316 278137003847 Integrase core domain; Region: rve_3; cl15866 278137003848 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 278137003849 Sodium:solute symporter family; Region: SSF; cl00456 278137003850 Transposase domain (DUF772); Region: DUF772; pfam05598 278137003851 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137003852 DDE superfamily endonuclease; Region: DDE_4; cl15789 278137003853 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 278137003854 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 278137003855 Na binding site [ion binding]; other site 278137003856 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 278137003857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137003858 active site 278137003859 phosphorylation site [posttranslational modification] 278137003860 intermolecular recognition site; other site 278137003861 dimerization interface [polypeptide binding]; other site 278137003862 LytTr DNA-binding domain; Region: LytTR; cl04498 278137003863 Histidine kinase; Region: His_kinase; pfam06580 278137003864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137003865 ATP binding site [chemical binding]; other site 278137003866 Mg2+ binding site [ion binding]; other site 278137003867 G-X-G motif; other site 278137003868 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137003869 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 278137003870 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 278137003871 Presynaptic Site I dimer interface [polypeptide binding]; other site 278137003872 catalytic residues [active] 278137003873 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 278137003874 Synaptic Flat tetramer interface [polypeptide binding]; other site 278137003875 Synaptic Site I dimer interface [polypeptide binding]; other site 278137003876 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 278137003877 FMN binding site [chemical binding]; other site 278137003878 dimer interface [polypeptide binding]; other site 278137003879 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 278137003880 aromatic arch; other site 278137003881 DCoH dimer interaction site [polypeptide binding]; other site 278137003882 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 278137003883 DCoH tetramer interaction site [polypeptide binding]; other site 278137003884 substrate binding site [chemical binding]; other site 278137003885 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 278137003886 active site 278137003887 8-oxo-dGMP binding site [chemical binding]; other site 278137003888 nudix motif; other site 278137003889 metal binding site [ion binding]; metal-binding site 278137003890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137003891 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 278137003892 putative substrate translocation pore; other site 278137003893 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 278137003894 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 278137003895 [4Fe-4S] binding site [ion binding]; other site 278137003896 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137003897 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137003898 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137003899 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 278137003900 molybdopterin cofactor binding site; other site 278137003901 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 278137003902 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 278137003903 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 278137003904 Protein of unknown function, DUF488; Region: DUF488; cl01246 278137003905 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 278137003906 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 278137003907 G1 box; other site 278137003908 putative GEF interaction site [polypeptide binding]; other site 278137003909 GTP/Mg2+ binding site [chemical binding]; other site 278137003910 Switch I region; other site 278137003911 G2 box; other site 278137003912 G3 box; other site 278137003913 Switch II region; other site 278137003914 G4 box; other site 278137003915 G5 box; other site 278137003916 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 278137003917 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 278137003918 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 278137003919 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 278137003920 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 278137003921 FO synthase; Reviewed; Region: fbiC; PRK09234 278137003922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137003923 FeS/SAM binding site; other site 278137003924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137003925 FeS/SAM binding site; other site 278137003926 YceI-like domain; Region: YceI; cl01001 278137003927 Ferredoxin [Energy production and conversion]; Region: COG1146 278137003928 4Fe-4S binding domain; Region: Fer4; cl02805 278137003929 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 278137003930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278137003931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137003932 homodimer interface [polypeptide binding]; other site 278137003933 catalytic residue [active] 278137003934 Proline dehydrogenase; Region: Pro_dh; cl03282 278137003935 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 278137003936 NAD(P) binding site [chemical binding]; other site 278137003937 catalytic residues [active] 278137003938 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 278137003939 dimer interface [polypeptide binding]; other site 278137003940 ADP-ribose binding site [chemical binding]; other site 278137003941 active site 278137003942 nudix motif; other site 278137003943 metal binding site [ion binding]; metal-binding site 278137003944 acyl-CoA synthetase; Validated; Region: PRK07787 278137003945 AMP-binding enzyme; Region: AMP-binding; cl15778 278137003946 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137003947 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 278137003948 active site 278137003949 metal binding site [ion binding]; metal-binding site 278137003950 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 278137003951 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 278137003952 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 278137003953 putative trimer interface [polypeptide binding]; other site 278137003954 putative CoA binding site [chemical binding]; other site 278137003955 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 278137003956 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 278137003957 metal binding site [ion binding]; metal-binding site 278137003958 putative dimer interface [polypeptide binding]; other site 278137003959 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278137003960 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278137003961 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278137003962 Proteins of 100 residues with WXG; Region: WXG100; cl02005 278137003963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137003964 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 278137003965 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 278137003966 AMP-binding enzyme; Region: AMP-binding; cl15778 278137003967 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 278137003968 dihydropteroate synthase; Region: DHPS; TIGR01496 278137003969 substrate binding pocket [chemical binding]; other site 278137003970 dimer interface [polypeptide binding]; other site 278137003971 inhibitor binding site; inhibition site 278137003972 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 278137003973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137003974 active site 278137003975 DivIVA domain; Region: DivI1A_domain; TIGR03544 278137003976 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 278137003977 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 278137003978 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 278137003979 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137003980 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 278137003981 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137003982 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 278137003983 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 278137003984 ligand binding site; other site 278137003985 oligomer interface; other site 278137003986 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 278137003987 dimer interface [polypeptide binding]; other site 278137003988 N-terminal domain interface [polypeptide binding]; other site 278137003989 sulfate 1 binding site; other site 278137003990 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 278137003991 Phospholipid methyltransferase; Region: PEMT; cl00763 278137003992 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137003993 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137003994 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 278137003995 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 278137003996 Walker A/P-loop; other site 278137003997 ATP binding site [chemical binding]; other site 278137003998 Q-loop/lid; other site 278137003999 ABC transporter signature motif; other site 278137004000 Walker B; other site 278137004001 D-loop; other site 278137004002 H-loop/switch region; other site 278137004003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137004004 Helix-turn-helix domains; Region: HTH; cl00088 278137004005 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 278137004006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137004007 S-adenosylmethionine binding site [chemical binding]; other site 278137004008 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 278137004009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137004010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137004011 DNA binding residues [nucleotide binding] 278137004012 Putative zinc-finger; Region: zf-HC2; cl15806 278137004013 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 278137004014 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 278137004015 protein binding site [polypeptide binding]; other site 278137004016 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 278137004017 Domain of unknown function DUF59; Region: DUF59; cl00941 278137004018 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 278137004019 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 278137004020 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 278137004021 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 278137004022 N-acetyl-D-glucosamine binding site [chemical binding]; other site 278137004023 catalytic residue [active] 278137004024 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 278137004025 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 278137004026 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 278137004027 MgtE intracellular N domain; Region: MgtE_N; cl15244 278137004028 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 278137004029 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137004030 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 278137004031 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 278137004032 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 278137004033 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 278137004034 Malic enzyme, N-terminal domain; Region: malic; pfam00390 278137004035 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 278137004036 putative NAD(P) binding site [chemical binding]; other site 278137004037 NMT1-like family; Region: NMT1_2; cl15260 278137004038 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 278137004039 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278137004040 classical (c) SDRs; Region: SDR_c; cd05233 278137004041 NAD(P) binding site [chemical binding]; other site 278137004042 active site 278137004043 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137004044 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 278137004045 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 278137004046 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 278137004047 TPP-binding site [chemical binding]; other site 278137004048 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 278137004049 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 278137004050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137004051 putative substrate translocation pore; other site 278137004052 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278137004053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137004054 putative substrate translocation pore; other site 278137004055 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 278137004056 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 278137004057 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 278137004058 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 278137004059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137004060 Family description; Region: UvrD_C_2; cl15862 278137004061 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 278137004062 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 278137004063 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 278137004064 ATP binding site [chemical binding]; other site 278137004065 Mg++ binding site [ion binding]; other site 278137004066 motif III; other site 278137004067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137004068 nucleotide binding region [chemical binding]; other site 278137004069 ATP-binding site [chemical binding]; other site 278137004070 DbpA RNA binding domain; Region: DbpA; pfam03880 278137004071 OpgC protein; Region: OpgC_C; cl00792 278137004072 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 278137004073 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 278137004074 FAD binding pocket [chemical binding]; other site 278137004075 FAD binding motif [chemical binding]; other site 278137004076 phosphate binding motif [ion binding]; other site 278137004077 NAD binding pocket [chemical binding]; other site 278137004078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137004079 Helix-turn-helix domains; Region: HTH; cl00088 278137004080 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137004081 FAD binding domain; Region: FAD_binding_4; pfam01565 278137004082 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 278137004083 Helix-turn-helix domains; Region: HTH; cl00088 278137004084 H+ Antiporter protein; Region: 2A0121; TIGR00900 278137004085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137004086 PknH-like extracellular domain; Region: PknH_C; pfam14032 278137004087 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 278137004088 Fe-S cluster binding site [ion binding]; other site 278137004089 DNA binding site [nucleotide binding] 278137004090 active site 278137004091 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137004092 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137004093 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 278137004094 HIT family signature motif; other site 278137004095 catalytic residue [active] 278137004096 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 278137004097 putative dimer interface [polypeptide binding]; other site 278137004098 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137004099 Helix-turn-helix domain; Region: HTH_18; pfam12833 278137004100 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 278137004101 putative active site [active] 278137004102 cyclase homology domain; Region: CHD; cd07302 278137004103 nucleotidyl binding site; other site 278137004104 metal binding site [ion binding]; metal-binding site 278137004105 dimer interface [polypeptide binding]; other site 278137004106 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 278137004107 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 278137004108 metal-binding site [ion binding] 278137004109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137004110 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137004111 Domain of unknown function (DUF305); Region: DUF305; cl15795 278137004112 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 278137004113 putative active site [active] 278137004114 dimerization interface [polypeptide binding]; other site 278137004115 putative tRNAtyr binding site [nucleotide binding]; other site 278137004116 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 278137004117 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 278137004118 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 278137004119 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137004120 molybdopterin cofactor binding site; other site 278137004121 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 278137004122 molybdopterin cofactor binding site; other site 278137004123 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278137004124 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278137004125 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 278137004126 Walker A/P-loop; other site 278137004127 ATP binding site [chemical binding]; other site 278137004128 Q-loop/lid; other site 278137004129 ABC transporter signature motif; other site 278137004130 Walker B; other site 278137004131 D-loop; other site 278137004132 H-loop/switch region; other site 278137004133 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278137004134 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278137004135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137004136 Walker A/P-loop; other site 278137004137 ATP binding site [chemical binding]; other site 278137004138 Q-loop/lid; other site 278137004139 ABC transporter signature motif; other site 278137004140 Walker B; other site 278137004141 D-loop; other site 278137004142 H-loop/switch region; other site 278137004143 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 278137004144 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 278137004145 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137004146 catalytic core [active] 278137004147 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 278137004148 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 278137004149 active site 278137004150 metal binding site [ion binding]; metal-binding site 278137004151 DNA binding site [nucleotide binding] 278137004152 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 278137004153 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137004154 Uncharacterized conserved protein [Function unknown]; Region: COG4717 278137004155 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 278137004156 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137004157 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 278137004158 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 278137004159 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 278137004160 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 278137004161 Walker A/P-loop; other site 278137004162 ATP binding site [chemical binding]; other site 278137004163 Q-loop/lid; other site 278137004164 ABC transporter signature motif; other site 278137004165 Walker B; other site 278137004166 D-loop; other site 278137004167 H-loop/switch region; other site 278137004168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 278137004169 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 278137004170 Walker A/P-loop; other site 278137004171 ATP binding site [chemical binding]; other site 278137004172 Q-loop/lid; other site 278137004173 ABC transporter signature motif; other site 278137004174 Walker B; other site 278137004175 D-loop; other site 278137004176 H-loop/switch region; other site 278137004177 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 278137004178 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 278137004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137004180 dimer interface [polypeptide binding]; other site 278137004181 conserved gate region; other site 278137004182 putative PBP binding loops; other site 278137004183 ABC-ATPase subunit interface; other site 278137004184 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 278137004185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137004186 dimer interface [polypeptide binding]; other site 278137004187 conserved gate region; other site 278137004188 putative PBP binding loops; other site 278137004189 ABC-ATPase subunit interface; other site 278137004190 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137004191 MULE transposase domain; Region: MULE; pfam10551 278137004192 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137004193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137004194 active site 278137004195 phosphorylation site [posttranslational modification] 278137004196 intermolecular recognition site; other site 278137004197 dimerization interface [polypeptide binding]; other site 278137004198 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137004199 DNA binding site [nucleotide binding] 278137004200 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 278137004201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137004202 dimer interface [polypeptide binding]; other site 278137004203 phosphorylation site [posttranslational modification] 278137004204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137004205 ATP binding site [chemical binding]; other site 278137004206 Mg2+ binding site [ion binding]; other site 278137004207 G-X-G motif; other site 278137004208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137004209 active site 278137004210 GtrA-like protein; Region: GtrA; cl00971 278137004211 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 278137004212 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 278137004213 active site clefts [active] 278137004214 zinc binding site [ion binding]; other site 278137004215 dimer interface [polypeptide binding]; other site 278137004216 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 278137004217 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 278137004218 Active Sites [active] 278137004219 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 278137004220 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 278137004221 CysD dimerization site [polypeptide binding]; other site 278137004222 G1 box; other site 278137004223 putative GEF interaction site [polypeptide binding]; other site 278137004224 GTP/Mg2+ binding site [chemical binding]; other site 278137004225 Switch I region; other site 278137004226 G2 box; other site 278137004227 G3 box; other site 278137004228 Switch II region; other site 278137004229 G4 box; other site 278137004230 G5 box; other site 278137004231 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 278137004232 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 278137004233 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 278137004234 ligand-binding site [chemical binding]; other site 278137004235 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 278137004236 active site 278137004237 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 278137004238 catalytic triad [active] 278137004239 conserved cis-peptide bond; other site 278137004240 Rrf2 family protein; Region: rrf2_super; TIGR00738 278137004241 Helix-turn-helix domains; Region: HTH; cl00088 278137004242 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137004243 Nitronate monooxygenase; Region: NMO; pfam03060 278137004244 FMN binding site [chemical binding]; other site 278137004245 substrate binding site [chemical binding]; other site 278137004246 putative catalytic residue [active] 278137004247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004248 probable polyamine oxidase; Region: PLN02268 278137004249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 278137004250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137004251 active site 278137004252 phosphorylation site [posttranslational modification] 278137004253 intermolecular recognition site; other site 278137004254 dimerization interface [polypeptide binding]; other site 278137004255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137004256 DNA binding residues [nucleotide binding] 278137004257 dimerization interface [polypeptide binding]; other site 278137004258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 278137004259 Histidine kinase; Region: HisKA_3; pfam07730 278137004260 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 278137004261 gating phenylalanine in ion channel; other site 278137004262 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 278137004263 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137004264 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 278137004265 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 278137004266 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 278137004267 active site 278137004268 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 278137004269 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004270 active site 278137004271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004272 NAD(P) binding site [chemical binding]; other site 278137004273 active site 278137004274 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 278137004275 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 278137004276 N-acetyl-D-glucosamine binding site [chemical binding]; other site 278137004277 catalytic residue [active] 278137004278 MspA; Region: MspA; pfam09203 278137004279 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 278137004280 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 278137004281 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 278137004282 active site 278137004283 HIGH motif; other site 278137004284 KMSK motif region; other site 278137004285 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 278137004286 tRNA binding surface [nucleotide binding]; other site 278137004287 anticodon binding site; other site 278137004288 diaminopimelate decarboxylase; Region: lysA; TIGR01048 278137004289 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 278137004290 active site 278137004291 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 278137004292 substrate binding site [chemical binding]; other site 278137004293 catalytic residues [active] 278137004294 dimer interface [polypeptide binding]; other site 278137004295 homoserine dehydrogenase; Provisional; Region: PRK06349 278137004296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004297 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 278137004298 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 278137004299 threonine synthase; Reviewed; Region: PRK06721 278137004300 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 278137004301 homodimer interface [polypeptide binding]; other site 278137004302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137004303 catalytic residue [active] 278137004304 homoserine kinase; Provisional; Region: PRK01212 278137004305 transcription termination factor Rho; Provisional; Region: PRK12678 278137004306 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 278137004307 transcription termination factor Rho; Provisional; Region: PRK12608 278137004308 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 278137004309 RNA binding site [nucleotide binding]; other site 278137004310 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 278137004311 multimer interface [polypeptide binding]; other site 278137004312 Walker A motif; other site 278137004313 ATP binding site [chemical binding]; other site 278137004314 Walker B motif; other site 278137004315 Helix-turn-helix domains; Region: HTH; cl00088 278137004316 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137004317 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 278137004318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137004319 Helix-turn-helix domains; Region: HTH; cl00088 278137004320 acyl-CoA synthetase; Provisional; Region: PRK13388 278137004321 AMP-binding enzyme; Region: AMP-binding; cl15778 278137004322 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 278137004323 RF-1 domain; Region: RF-1; cl02875 278137004324 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 278137004325 RF-1 domain; Region: RF-1; cl02875 278137004326 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 278137004327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137004328 S-adenosylmethionine binding site [chemical binding]; other site 278137004329 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 278137004330 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 278137004331 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 278137004332 Mg++ binding site [ion binding]; other site 278137004333 putative catalytic motif [active] 278137004334 substrate binding site [chemical binding]; other site 278137004335 ATP synthase A chain; Region: ATP-synt_A; cl00413 278137004336 ATP synthase subunit C; Region: ATP-synt_C; cl00466 278137004337 Plant ATP synthase F0; Region: YMF19; cl07975 278137004338 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 278137004339 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 278137004340 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 278137004341 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 278137004342 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 278137004343 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 278137004344 beta subunit interaction interface [polypeptide binding]; other site 278137004345 Walker A motif; other site 278137004346 ATP binding site [chemical binding]; other site 278137004347 Walker B motif; other site 278137004348 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 278137004349 ATP synthase; Region: ATP-synt; cl00365 278137004350 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 278137004351 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 278137004352 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 278137004353 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 278137004354 alpha subunit interaction interface [polypeptide binding]; other site 278137004355 Walker A motif; other site 278137004356 ATP binding site [chemical binding]; other site 278137004357 Walker B motif; other site 278137004358 inhibitor binding site; inhibition site 278137004359 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 278137004360 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 278137004361 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 278137004362 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 278137004363 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 278137004364 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 278137004365 hinge; other site 278137004366 active site 278137004367 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 278137004368 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 278137004369 DNA binding site [nucleotide binding] 278137004370 active site 278137004371 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 278137004372 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 278137004373 AlkA N-terminal domain; Region: AlkA_N; cl05528 278137004374 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 278137004375 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 278137004376 minor groove reading motif; other site 278137004377 helix-hairpin-helix signature motif; other site 278137004378 substrate binding pocket [chemical binding]; other site 278137004379 active site 278137004380 Helix-turn-helix domains; Region: HTH; cl00088 278137004381 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137004382 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 278137004383 [2Fe-2S] cluster binding site [ion binding]; other site 278137004384 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 278137004385 putative alpha subunit interface [polypeptide binding]; other site 278137004386 putative active site [active] 278137004387 putative substrate binding site [chemical binding]; other site 278137004388 Fe binding site [ion binding]; other site 278137004389 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137004390 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137004391 Glutaminase; Region: Glutaminase; cl00907 278137004392 Helix-turn-helix domains; Region: HTH; cl00088 278137004393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137004394 dimerization interface [polypeptide binding]; other site 278137004395 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137004396 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137004397 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137004398 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137004399 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004401 active site 278137004402 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 278137004403 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137004404 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 278137004405 active site 278137004406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278137004407 dimerization interface [polypeptide binding]; other site 278137004408 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 278137004409 cyclase homology domain; Region: CHD; cd07302 278137004410 nucleotidyl binding site; other site 278137004411 metal binding site [ion binding]; metal-binding site 278137004412 dimer interface [polypeptide binding]; other site 278137004413 Protein of unknown function DUF91; Region: DUF91; cl00709 278137004414 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 278137004415 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137004416 dimer interface [polypeptide binding]; other site 278137004417 substrate binding site [chemical binding]; other site 278137004418 metal binding site [ion binding]; metal-binding site 278137004419 putative acyltransferase; Provisional; Region: PRK05790 278137004420 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137004421 dimer interface [polypeptide binding]; other site 278137004422 active site 278137004423 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 278137004424 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 278137004425 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 278137004426 glycogen branching enzyme; Provisional; Region: PRK05402 278137004427 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 278137004428 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 278137004429 active site 278137004430 catalytic site [active] 278137004431 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 278137004432 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 278137004433 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 278137004434 active site 278137004435 homodimer interface [polypeptide binding]; other site 278137004436 catalytic site [active] 278137004437 acceptor binding site [chemical binding]; other site 278137004438 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 278137004439 putative homodimer interface [polypeptide binding]; other site 278137004440 putative active site pocket [active] 278137004441 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 278137004442 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 278137004443 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 278137004444 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137004445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137004446 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 278137004447 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 278137004448 active site 278137004449 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 278137004450 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 278137004451 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 278137004452 putative active site pocket [active] 278137004453 cleavage site 278137004454 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 278137004455 MPN+ (JAMM) motif; other site 278137004456 Zinc-binding site [ion binding]; other site 278137004457 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 278137004458 MoaE interaction surface [polypeptide binding]; other site 278137004459 MoeB interaction surface [polypeptide binding]; other site 278137004460 thiocarboxylated glycine; other site 278137004461 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 278137004462 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 278137004463 dimer interface [polypeptide binding]; other site 278137004464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137004465 catalytic residue [active] 278137004466 Rhomboid family; Region: Rhomboid; cl11446 278137004467 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 278137004468 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137004469 ribonuclease PH; Reviewed; Region: rph; PRK00173 278137004470 Ribonuclease PH; Region: RNase_PH_bact; cd11362 278137004471 hexamer interface [polypeptide binding]; other site 278137004472 active site 278137004473 OpgC protein; Region: OpgC_C; cl00792 278137004474 Acyltransferase family; Region: Acyl_transf_3; pfam01757 278137004475 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 278137004476 Glucitol operon activator protein (GutM); Region: GutM; cl01890 278137004477 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 278137004478 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137004479 Cupin domain; Region: Cupin_2; cl09118 278137004480 Helix-turn-helix domain; Region: HTH_18; pfam12833 278137004481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137004482 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137004483 Sulfatase; Region: Sulfatase; cl10460 278137004484 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137004485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137004486 Helix-turn-helix domains; Region: HTH; cl00088 278137004487 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 278137004488 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 278137004489 putative NADP binding site [chemical binding]; other site 278137004490 putative substrate binding site [chemical binding]; other site 278137004491 active site 278137004492 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004493 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137004494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004495 active site 278137004496 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004497 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004498 active site 278137004499 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137004500 active site 278137004501 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 278137004502 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137004503 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137004504 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 278137004505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004506 NAD(P) binding site [chemical binding]; other site 278137004507 active site 278137004508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137004509 metabolite-proton symporter; Region: 2A0106; TIGR00883 278137004510 putative substrate translocation pore; other site 278137004511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278137004512 dimerization interface [polypeptide binding]; other site 278137004513 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 278137004514 cyclase homology domain; Region: CHD; cd07302 278137004515 nucleotidyl binding site; other site 278137004516 metal binding site [ion binding]; metal-binding site 278137004517 dimer interface [polypeptide binding]; other site 278137004518 metabolite-proton symporter; Region: 2A0106; TIGR00883 278137004519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137004520 putative substrate translocation pore; other site 278137004521 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 278137004522 AMP-binding enzyme; Region: AMP-binding; cl15778 278137004523 AMP-binding enzyme; Region: AMP-binding; cl15778 278137004524 short chain dehydrogenase; Provisional; Region: PRK08278 278137004525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004526 NAD(P) binding site [chemical binding]; other site 278137004527 active site 278137004528 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 278137004529 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 278137004530 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 278137004531 B12 binding site [chemical binding]; other site 278137004532 cobalt ligand [ion binding]; other site 278137004533 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 278137004534 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137004535 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137004536 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137004537 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137004538 catalytic loop [active] 278137004539 iron binding site [ion binding]; other site 278137004540 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 278137004541 AMP-binding enzyme; Region: AMP-binding; cl15778 278137004542 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137004543 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004544 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004545 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004546 active site 278137004547 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 278137004548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137004549 substrate binding site [chemical binding]; other site 278137004550 oxyanion hole (OAH) forming residues; other site 278137004551 trimer interface [polypeptide binding]; other site 278137004552 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 278137004553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004554 NAD(P) binding site [chemical binding]; other site 278137004555 active site 278137004556 ArgK protein; Region: ArgK; pfam03308 278137004557 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 278137004558 Walker A; other site 278137004559 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 278137004560 Transcriptional regulator [Transcription]; Region: IclR; COG1414 278137004561 Helix-turn-helix domains; Region: HTH; cl00088 278137004562 Bacterial transcriptional regulator; Region: IclR; pfam01614 278137004563 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137004564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137004565 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 278137004566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004568 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 278137004569 putative active site [active] 278137004570 Fe(II) binding site [ion binding]; other site 278137004571 putative dimer interface [polypeptide binding]; other site 278137004572 putative tetramer interface [polypeptide binding]; other site 278137004573 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 278137004574 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137004575 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 278137004576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004577 NAD(P) binding site [chemical binding]; other site 278137004578 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 278137004579 active site 278137004580 Putative cyclase; Region: Cyclase; cl00814 278137004581 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278137004582 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137004583 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137004584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004585 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137004586 NAD(P) binding site [chemical binding]; other site 278137004587 active site 278137004588 Helix-turn-helix domains; Region: HTH; cl00088 278137004589 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 278137004590 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137004591 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137004592 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137004593 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 278137004594 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 278137004595 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 278137004596 active site 278137004597 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 278137004598 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 278137004599 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 278137004600 active site 278137004601 enoyl-CoA hydratase; Provisional; Region: PRK12478 278137004602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137004603 substrate binding site [chemical binding]; other site 278137004604 oxyanion hole (OAH) forming residues; other site 278137004605 trimer interface [polypeptide binding]; other site 278137004606 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137004607 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137004608 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137004609 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137004610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004611 classical (c) SDRs; Region: SDR_c; cd05233 278137004612 NAD(P) binding site [chemical binding]; other site 278137004613 active site 278137004614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004616 active site 278137004617 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 278137004618 putative acyl-acceptor binding pocket; other site 278137004619 acyl-CoA synthetase; Provisional; Region: PRK13382 278137004620 AMP-binding enzyme; Region: AMP-binding; cl15778 278137004621 AMP-binding enzyme; Region: AMP-binding; cl15778 278137004622 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 278137004623 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137004624 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 278137004625 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137004626 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137004627 classical (c) SDRs; Region: SDR_c; cd05233 278137004628 NAD(P) binding site [chemical binding]; other site 278137004629 active site 278137004630 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137004631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137004632 Helix-turn-helix domains; Region: HTH; cl00088 278137004633 enoyl-CoA hydratase; Provisional; Region: PRK08290 278137004634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137004635 substrate binding site [chemical binding]; other site 278137004636 oxyanion hole (OAH) forming residues; other site 278137004637 trimer interface [polypeptide binding]; other site 278137004638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004639 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004641 active site 278137004642 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137004643 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137004644 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 278137004645 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 278137004646 active site 278137004647 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 278137004648 [2Fe-2S] cluster binding site [ion binding]; other site 278137004649 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 278137004650 alpha subunit interface [polypeptide binding]; other site 278137004651 active site 278137004652 substrate binding site [chemical binding]; other site 278137004653 Fe binding site [ion binding]; other site 278137004654 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137004655 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137004656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004658 active site 278137004659 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137004660 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137004661 enoyl-CoA hydratase; Provisional; Region: PRK06688 278137004662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137004663 substrate binding site [chemical binding]; other site 278137004664 oxyanion hole (OAH) forming residues; other site 278137004665 trimer interface [polypeptide binding]; other site 278137004666 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 278137004667 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137004668 dimer interface [polypeptide binding]; other site 278137004669 active site 278137004670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004672 active site 278137004673 Helix-turn-helix domains; Region: HTH; cl00088 278137004674 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 278137004675 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 278137004676 NAD(P) binding site [chemical binding]; other site 278137004677 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 278137004678 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 278137004679 putative active site [active] 278137004680 putative substrate binding site [chemical binding]; other site 278137004681 ATP binding site [chemical binding]; other site 278137004682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004683 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004684 active site 278137004685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137004686 Helix-turn-helix domains; Region: HTH; cl00088 278137004687 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137004688 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 278137004689 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 278137004690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004691 NAD(P) binding site [chemical binding]; other site 278137004692 active site 278137004693 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137004694 metal ion-dependent adhesion site (MIDAS); other site 278137004695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137004696 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 278137004697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137004698 Helix-turn-helix domains; Region: HTH; cl00088 278137004699 Helix-turn-helix domains; Region: HTH; cl00088 278137004700 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 278137004701 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137004702 classical (c) SDRs; Region: SDR_c; cd05233 278137004703 NAD(P) binding site [chemical binding]; other site 278137004704 active site 278137004705 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 278137004706 [2Fe-2S] cluster binding site [ion binding]; other site 278137004707 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 278137004708 alpha subunit interface [polypeptide binding]; other site 278137004709 active site 278137004710 substrate binding site [chemical binding]; other site 278137004711 Fe binding site [ion binding]; other site 278137004712 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 278137004713 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 278137004714 active site 278137004715 Helix-turn-helix domains; Region: HTH; cl00088 278137004716 Helix-turn-helix domains; Region: HTH; cl00088 278137004717 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 278137004718 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 278137004719 FAD binding pocket [chemical binding]; other site 278137004720 FAD binding motif [chemical binding]; other site 278137004721 phosphate binding motif [ion binding]; other site 278137004722 beta-alpha-beta structure motif; other site 278137004723 NAD(p) ribose binding residues [chemical binding]; other site 278137004724 NAD binding pocket [chemical binding]; other site 278137004725 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 278137004726 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137004727 catalytic loop [active] 278137004728 iron binding site [ion binding]; other site 278137004729 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137004730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004731 NAD(P) binding site [chemical binding]; other site 278137004732 active site 278137004733 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 278137004734 [2Fe-2S] cluster binding site [ion binding]; other site 278137004735 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 278137004736 alpha subunit interface [polypeptide binding]; other site 278137004737 active site 278137004738 substrate binding site [chemical binding]; other site 278137004739 Fe binding site [ion binding]; other site 278137004740 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 278137004741 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 278137004742 substrate binding pocket [chemical binding]; other site 278137004743 active site 278137004744 iron coordination sites [ion binding]; other site 278137004745 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137004746 Uncharacterized conserved protein [Function unknown]; Region: COG2128 278137004747 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137004748 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137004749 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 278137004750 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 278137004751 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137004752 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137004753 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137004754 Cytochrome P450; Region: p450; pfam00067 278137004755 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137004756 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 278137004757 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137004758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004759 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 278137004760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004761 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 278137004762 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137004763 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 278137004764 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137004765 lipid-transfer protein; Provisional; Region: PRK07855 278137004766 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137004767 active site 278137004768 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 278137004769 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 278137004770 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 278137004771 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137004772 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137004773 iron-sulfur cluster [ion binding]; other site 278137004774 [2Fe-2S] cluster binding site [ion binding]; other site 278137004775 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137004776 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137004777 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004778 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137004779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004780 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004781 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004782 active site 278137004783 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 278137004784 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137004785 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 278137004786 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 278137004787 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 278137004788 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137004789 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 278137004790 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137004791 classical (c) SDRs; Region: SDR_c; cd05233 278137004792 NAD(P) binding site [chemical binding]; other site 278137004793 active site 278137004794 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137004795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137004796 NAD(P) binding site [chemical binding]; other site 278137004797 active site 278137004798 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137004799 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 278137004800 NAD binding site [chemical binding]; other site 278137004801 catalytic residues [active] 278137004802 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137004803 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137004804 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 278137004805 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 278137004806 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137004807 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 278137004808 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137004809 active site 278137004810 Permease; Region: Permease; cl00510 278137004811 Permease; Region: Permease; cl00510 278137004812 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137004813 mce related protein; Region: MCE; pfam02470 278137004814 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137004815 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137004816 mce related protein; Region: MCE; pfam02470 278137004817 mce related protein; Region: MCE; pfam02470 278137004818 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137004819 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137004820 mce related protein; Region: MCE; pfam02470 278137004821 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137004822 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137004823 mce related protein; Region: MCE; pfam02470 278137004824 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137004825 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137004826 mce related protein; Region: MCE; pfam02470 278137004827 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137004828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137004829 Helix-turn-helix domains; Region: HTH; cl00088 278137004830 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 278137004831 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137004832 active site 278137004833 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 278137004834 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137004835 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 278137004836 dimer interface [polypeptide binding]; other site 278137004837 substrate binding site [chemical binding]; other site 278137004838 metal binding site [ion binding]; metal-binding site 278137004839 enoyl-CoA hydratase; Provisional; Region: PRK07827 278137004840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137004841 substrate binding site [chemical binding]; other site 278137004842 oxyanion hole (OAH) forming residues; other site 278137004843 trimer interface [polypeptide binding]; other site 278137004844 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 278137004845 AMP-binding enzyme; Region: AMP-binding; cl15778 278137004846 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137004847 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 278137004848 AMP-binding enzyme; Region: AMP-binding; cl15778 278137004849 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137004850 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 278137004851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137004852 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 278137004853 substrate binding site; other site 278137004854 dimer interface; other site 278137004855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278137004856 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278137004857 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278137004858 DNA binding residues [nucleotide binding] 278137004859 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137004860 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 278137004861 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137004862 FMN binding site [chemical binding]; other site 278137004863 substrate binding site [chemical binding]; other site 278137004864 putative catalytic residue [active] 278137004865 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 278137004866 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 278137004867 putative active site [active] 278137004868 putative catalytic site [active] 278137004869 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137004870 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 278137004871 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 278137004872 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 278137004873 putative NAD(P) binding site [chemical binding]; other site 278137004874 active site 278137004875 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 278137004876 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 278137004877 active site 278137004878 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 278137004879 hypothetical protein; Provisional; Region: PRK07907 278137004880 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 278137004881 active site 278137004882 metal binding site [ion binding]; metal-binding site 278137004883 dimer interface [polypeptide binding]; other site 278137004884 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 278137004885 catalytic triad [active] 278137004886 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 278137004887 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 278137004888 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 278137004889 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 278137004890 active site 278137004891 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 278137004892 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 278137004893 active site 278137004894 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 278137004895 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137004896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 278137004897 Bacterial Ig-like domain; Region: Big_5; cl01012 278137004898 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137004899 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 278137004900 catalytic site [active] 278137004901 putative active site [active] 278137004902 putative substrate binding site [chemical binding]; other site 278137004903 dimer interface [polypeptide binding]; other site 278137004904 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 278137004905 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278137004906 classical (c) SDRs; Region: SDR_c; cd05233 278137004907 NAD(P) binding site [chemical binding]; other site 278137004908 active site 278137004909 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 278137004910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137004911 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 278137004912 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137004913 Helix-turn-helix domains; Region: HTH; cl00088 278137004914 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137004915 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 278137004916 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137004917 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 278137004918 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278137004919 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137004920 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 278137004921 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278137004922 carboxyltransferase (CT) interaction site; other site 278137004923 biotinylation site [posttranslational modification]; other site 278137004924 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137004925 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137004926 active site 278137004927 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 278137004928 putative active site [active] 278137004929 putative catalytic site [active] 278137004930 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137004931 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 278137004932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137004933 substrate binding site [chemical binding]; other site 278137004934 oxyanion hole (OAH) forming residues; other site 278137004935 trimer interface [polypeptide binding]; other site 278137004936 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 278137004937 Helix-turn-helix domains; Region: HTH; cl00088 278137004938 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 278137004939 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137004940 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137004941 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 278137004942 putative active site [active] 278137004943 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137004944 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 278137004945 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 278137004946 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137004947 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 278137004948 putative acyl-acceptor binding pocket; other site 278137004949 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 278137004950 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 278137004951 putative acyl-acceptor binding pocket; other site 278137004952 Copper resistance protein D; Region: CopD; cl00563 278137004953 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 278137004954 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 278137004955 dimer interface [polypeptide binding]; other site 278137004956 ssDNA binding site [nucleotide binding]; other site 278137004957 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278137004958 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 278137004959 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137004960 Walker A/P-loop; other site 278137004961 ATP binding site [chemical binding]; other site 278137004962 Q-loop/lid; other site 278137004963 ABC transporter signature motif; other site 278137004964 Walker B; other site 278137004965 D-loop; other site 278137004966 H-loop/switch region; other site 278137004967 ABC transporter; Region: ABC_tran_2; pfam12848 278137004968 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278137004969 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 278137004970 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 278137004971 active site 278137004972 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 278137004973 apolar tunnel; other site 278137004974 heme binding site [chemical binding]; other site 278137004975 dimerization interface [polypeptide binding]; other site 278137004976 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137004977 active site 278137004978 Repair protein; Region: Repair_PSII; cl01535 278137004979 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137004980 active site 278137004981 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 278137004982 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 278137004983 Zn binding site [ion binding]; other site 278137004984 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 278137004985 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 278137004986 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 278137004987 nucleoside/Zn binding site; other site 278137004988 dimer interface [polypeptide binding]; other site 278137004989 catalytic motif [active] 278137004990 putative transposase OrfB; Reviewed; Region: PHA02517 278137004991 HTH-like domain; Region: HTH_21; pfam13276 278137004992 Integrase core domain; Region: rve; cl01316 278137004993 Integrase core domain; Region: rve_3; cl15866 278137004994 Helix-turn-helix domains; Region: HTH; cl00088 278137004995 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 278137004996 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 278137004997 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 278137004998 putative DNA binding site [nucleotide binding]; other site 278137004999 catalytic residue [active] 278137005000 putative H2TH interface [polypeptide binding]; other site 278137005001 putative catalytic residues [active] 278137005002 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 278137005003 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 278137005004 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 278137005005 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137005006 trigger factor; Provisional; Region: tig; PRK01490 278137005007 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 278137005008 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 278137005009 Clp protease; Region: CLP_protease; pfam00574 278137005010 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 278137005011 oligomer interface [polypeptide binding]; other site 278137005012 active site residues [active] 278137005013 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 278137005014 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 278137005015 oligomer interface [polypeptide binding]; other site 278137005016 active site residues [active] 278137005017 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137005018 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 278137005019 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 278137005020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137005021 Walker A motif; other site 278137005022 ATP binding site [chemical binding]; other site 278137005023 Walker B motif; other site 278137005024 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278137005025 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 278137005026 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 278137005027 active site 278137005028 TDP-binding site; other site 278137005029 acceptor substrate-binding pocket; other site 278137005030 homodimer interface [polypeptide binding]; other site 278137005031 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 278137005032 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 278137005033 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 278137005034 putative molybdopterin cofactor binding site [chemical binding]; other site 278137005035 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 278137005036 putative molybdopterin cofactor binding site; other site 278137005037 Helix-turn-helix domains; Region: HTH; cl00088 278137005038 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278137005039 dimerization interface [polypeptide binding]; other site 278137005040 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 278137005041 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 278137005042 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 278137005043 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278137005044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005045 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 278137005046 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 278137005047 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 278137005048 PYR/PP interface [polypeptide binding]; other site 278137005049 dimer interface [polypeptide binding]; other site 278137005050 TPP binding site [chemical binding]; other site 278137005051 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 278137005052 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 278137005053 TPP-binding site; other site 278137005054 KduI/IolB family; Region: KduI; cl01508 278137005055 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 278137005056 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 278137005057 substrate binding site [chemical binding]; other site 278137005058 ATP binding site [chemical binding]; other site 278137005059 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278137005060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137005061 DNA-binding site [nucleotide binding]; DNA binding site 278137005062 UTRA domain; Region: UTRA; cl01230 278137005063 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 278137005064 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 278137005065 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 278137005066 putative ligand binding site [chemical binding]; other site 278137005067 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 278137005068 TM-ABC transporter signature motif; other site 278137005069 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278137005070 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 278137005071 Walker A/P-loop; other site 278137005072 ATP binding site [chemical binding]; other site 278137005073 Q-loop/lid; other site 278137005074 ABC transporter signature motif; other site 278137005075 Walker B; other site 278137005076 D-loop; other site 278137005077 H-loop/switch region; other site 278137005078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 278137005079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 278137005080 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 278137005081 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 278137005082 putative hydrophobic ligand binding site [chemical binding]; other site 278137005083 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278137005084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005085 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 278137005086 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 278137005087 Metal-binding active site; metal-binding site 278137005088 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278137005089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005090 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 278137005091 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 278137005092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278137005093 DNA binding site [nucleotide binding] 278137005094 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 278137005095 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 278137005096 putative ligand binding site [chemical binding]; other site 278137005097 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 278137005098 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 278137005099 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 278137005100 dimer interface [polypeptide binding]; other site 278137005101 PYR/PP interface [polypeptide binding]; other site 278137005102 TPP binding site [chemical binding]; other site 278137005103 substrate binding site [chemical binding]; other site 278137005104 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 278137005105 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 278137005106 TPP-binding site [chemical binding]; other site 278137005107 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 278137005108 GTP binding site; other site 278137005109 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278137005110 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 278137005111 hypothetical protein; Provisional; Region: PRK06753 278137005112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005113 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 278137005114 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 278137005115 FMN-binding pocket [chemical binding]; other site 278137005116 flavin binding motif; other site 278137005117 phosphate binding motif [ion binding]; other site 278137005118 beta-alpha-beta structure motif; other site 278137005119 NAD binding pocket [chemical binding]; other site 278137005120 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137005121 catalytic loop [active] 278137005122 iron binding site [ion binding]; other site 278137005123 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 278137005124 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 278137005125 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 278137005126 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137005127 Uncharacterized conserved protein [Function unknown]; Region: COG3268 278137005128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005129 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 278137005130 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 278137005131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278137005132 active site 278137005133 HIGH motif; other site 278137005134 nucleotide binding site [chemical binding]; other site 278137005135 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 278137005136 active site 278137005137 KMSKS motif; other site 278137005138 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 278137005139 tRNA binding surface [nucleotide binding]; other site 278137005140 anticodon binding site; other site 278137005141 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 278137005142 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 278137005143 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278137005144 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278137005145 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 278137005146 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 278137005147 active site 278137005148 multimer interface [polypeptide binding]; other site 278137005149 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278137005150 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 278137005151 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 278137005152 homodimer interface [polypeptide binding]; other site 278137005153 oligonucleotide binding site [chemical binding]; other site 278137005154 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 278137005155 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 278137005156 GTPase CgtA; Reviewed; Region: obgE; PRK12296 278137005157 GTP1/OBG; Region: GTP1_OBG; pfam01018 278137005158 Obg GTPase; Region: Obg; cd01898 278137005159 G1 box; other site 278137005160 GTP/Mg2+ binding site [chemical binding]; other site 278137005161 Switch I region; other site 278137005162 G2 box; other site 278137005163 G3 box; other site 278137005164 Switch II region; other site 278137005165 G4 box; other site 278137005166 G5 box; other site 278137005167 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 278137005168 gamma-glutamyl kinase; Provisional; Region: PRK05429 278137005169 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 278137005170 nucleotide binding site [chemical binding]; other site 278137005171 homotetrameric interface [polypeptide binding]; other site 278137005172 putative phosphate binding site [ion binding]; other site 278137005173 putative allosteric binding site; other site 278137005174 PUA domain; Region: PUA; cl00607 278137005175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137005176 Helix-turn-helix domains; Region: HTH; cl00088 278137005177 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137005178 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 278137005179 NAD-dependent deacetylase; Provisional; Region: PRK05333 278137005180 NAD+ binding site [chemical binding]; other site 278137005181 substrate binding site [chemical binding]; other site 278137005182 Zn binding site [ion binding]; other site 278137005183 NAD synthetase; Reviewed; Region: nadE; PRK02628 278137005184 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 278137005185 multimer interface [polypeptide binding]; other site 278137005186 active site 278137005187 catalytic triad [active] 278137005188 protein interface 1 [polypeptide binding]; other site 278137005189 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 278137005190 homodimer interface [polypeptide binding]; other site 278137005191 NAD binding pocket [chemical binding]; other site 278137005192 ATP binding pocket [chemical binding]; other site 278137005193 Mg binding site [ion binding]; other site 278137005194 active-site loop [active] 278137005195 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 278137005196 substrate binding site [chemical binding]; other site 278137005197 ATP binding site [chemical binding]; other site 278137005198 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 278137005199 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 278137005200 putative catalytic cysteine [active] 278137005201 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 278137005202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137005203 Walker A motif; other site 278137005204 ATP binding site [chemical binding]; other site 278137005205 Walker B motif; other site 278137005206 arginine finger; other site 278137005207 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 278137005208 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137005209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 278137005210 Predicted dehydrogenase [General function prediction only]; Region: COG0579 278137005211 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 278137005212 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 278137005213 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 278137005214 N- and C-terminal domain interface [polypeptide binding]; other site 278137005215 active site 278137005216 MgATP binding site [chemical binding]; other site 278137005217 catalytic site [active] 278137005218 metal binding site [ion binding]; metal-binding site 278137005219 carbohydrate binding site [chemical binding]; other site 278137005220 Spore germination protein; Region: Spore_permease; cl15802 278137005221 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 278137005222 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278137005223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137005224 DNA-binding site [nucleotide binding]; DNA binding site 278137005225 UTRA domain; Region: UTRA; cl01230 278137005226 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 278137005227 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 278137005228 active site 278137005229 (T/H)XGH motif; other site 278137005230 Oligomerisation domain; Region: Oligomerisation; cl00519 278137005231 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137005232 catalytic core [active] 278137005233 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 278137005234 active site 278137005235 catalytic triad [active] 278137005236 oxyanion hole [active] 278137005237 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 278137005238 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137005239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005241 NAD(P) binding site [chemical binding]; other site 278137005242 active site 278137005243 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 278137005244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137005245 Helix-turn-helix domains; Region: HTH; cl00088 278137005246 putative transposase OrfB; Reviewed; Region: PHA02517 278137005247 HTH-like domain; Region: HTH_21; pfam13276 278137005248 Integrase core domain; Region: rve; cl01316 278137005249 Integrase core domain; Region: rve_3; cl15866 278137005250 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 278137005251 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 278137005252 Competence protein; Region: Competence; cl00471 278137005253 hypothetical protein; Reviewed; Region: PRK07914 278137005254 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 278137005255 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 278137005256 Uncharacterized conserved protein [Function unknown]; Region: COG2308 278137005257 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 278137005258 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 278137005259 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 278137005260 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 278137005261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137005262 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 278137005263 FOG: CBS domain [General function prediction only]; Region: COG0517 278137005264 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137005265 PemK-like protein; Region: PemK; cl00995 278137005266 GTP-binding protein LepA; Provisional; Region: PRK05433 278137005267 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 278137005268 G1 box; other site 278137005269 putative GEF interaction site [polypeptide binding]; other site 278137005270 GTP/Mg2+ binding site [chemical binding]; other site 278137005271 Switch I region; other site 278137005272 G2 box; other site 278137005273 G3 box; other site 278137005274 Switch II region; other site 278137005275 G4 box; other site 278137005276 G5 box; other site 278137005277 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 278137005278 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 278137005279 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 278137005280 PknH-like extracellular domain; Region: PknH_C; pfam14032 278137005281 PknH-like extracellular domain; Region: PknH_C; pfam14032 278137005282 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 278137005283 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 278137005284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137005285 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 278137005286 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 278137005287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137005288 dimer interface [polypeptide binding]; other site 278137005289 conserved gate region; other site 278137005290 putative PBP binding loops; other site 278137005291 ABC-ATPase subunit interface; other site 278137005292 sulfate transport protein; Provisional; Region: cysT; CHL00187 278137005293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137005294 dimer interface [polypeptide binding]; other site 278137005295 conserved gate region; other site 278137005296 putative PBP binding loops; other site 278137005297 ABC-ATPase subunit interface; other site 278137005298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137005299 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 278137005300 Walker A/P-loop; other site 278137005301 ATP binding site [chemical binding]; other site 278137005302 Q-loop/lid; other site 278137005303 ABC transporter signature motif; other site 278137005304 Walker B; other site 278137005305 D-loop; other site 278137005306 H-loop/switch region; other site 278137005307 TOBE-like domain; Region: TOBE_3; pfam12857 278137005308 Domain of unknown function DUF21; Region: DUF21; pfam01595 278137005309 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 278137005310 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 278137005311 Domain of unknown function DUF21; Region: DUF21; pfam01595 278137005312 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 278137005313 Transporter associated domain; Region: CorC_HlyC; cl08393 278137005314 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 278137005315 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 278137005316 putative active site [active] 278137005317 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 278137005318 putative active site [active] 278137005319 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 278137005320 Active Sites [active] 278137005321 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 278137005322 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 278137005323 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 278137005324 coproporphyrinogen III oxidase; Validated; Region: PRK05628 278137005325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137005326 FeS/SAM binding site; other site 278137005327 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137005328 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 278137005329 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137005330 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 278137005331 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137005332 active site 278137005333 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137005334 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 278137005335 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 278137005336 putative NADP binding site [chemical binding]; other site 278137005337 active site 278137005338 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137005339 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 278137005340 AMP-binding enzyme; Region: AMP-binding; cl15778 278137005341 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137005342 Condensation domain; Region: Condensation; pfam00668 278137005343 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 278137005344 Nonribosomal peptide synthase; Region: NRPS; pfam08415 278137005345 AMP-binding enzyme; Region: AMP-binding; cl15778 278137005346 acyl-CoA synthetase; Validated; Region: PRK08308 278137005347 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 278137005348 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137005349 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 278137005350 active site 278137005351 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137005352 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 278137005353 NADP binding site [chemical binding]; other site 278137005354 active site 278137005355 peptide synthase; Provisional; Region: PRK12467 278137005356 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 278137005357 AMP-binding enzyme; Region: AMP-binding; cl15778 278137005358 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137005359 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 278137005360 peptide synthase; Provisional; Region: PRK12467 278137005361 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137005362 peptide synthase; Provisional; Region: PRK12316 278137005363 AMP-binding enzyme; Region: AMP-binding; cl15778 278137005364 AMP-binding enzyme; Region: AMP-binding; cl15778 278137005365 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137005366 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 278137005367 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 278137005368 MbtH-like protein; Region: MbtH; cl01279 278137005369 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 278137005370 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 278137005371 Helix-turn-helix domains; Region: HTH; cl00088 278137005372 HrcA protein C terminal domain; Region: HrcA; pfam01628 278137005373 chaperone protein DnaJ; Provisional; Region: PRK14278 278137005374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 278137005375 HSP70 interaction site [polypeptide binding]; other site 278137005376 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 278137005377 Zn binding sites [ion binding]; other site 278137005378 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 278137005379 dimer interface [polypeptide binding]; other site 278137005380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 278137005381 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 278137005382 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 278137005383 Transport protein; Region: actII; TIGR00833 278137005384 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 278137005385 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 278137005386 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137005387 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 278137005388 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 278137005389 Domain of unknown function DUF21; Region: DUF21; pfam01595 278137005390 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 278137005391 Transporter associated domain; Region: CorC_HlyC; cl08393 278137005392 GTPase Era; Reviewed; Region: era; PRK00089 278137005393 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 278137005394 G1 box; other site 278137005395 GTP/Mg2+ binding site [chemical binding]; other site 278137005396 Switch I region; other site 278137005397 G2 box; other site 278137005398 Switch II region; other site 278137005399 G3 box; other site 278137005400 G4 box; other site 278137005401 G5 box; other site 278137005402 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 278137005403 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 278137005404 amidase; Provisional; Region: PRK06061 278137005405 Amidase; Region: Amidase; cl11426 278137005406 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 278137005407 Recombination protein O N terminal; Region: RecO_N; cl15812 278137005408 Recombination protein O C terminal; Region: RecO_C; pfam02565 278137005409 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 278137005410 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 278137005411 catalytic residue [active] 278137005412 putative FPP diphosphate binding site; other site 278137005413 putative FPP binding hydrophobic cleft; other site 278137005414 dimer interface [polypeptide binding]; other site 278137005415 putative IPP diphosphate binding site; other site 278137005416 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 278137005417 metal binding site 2 [ion binding]; metal-binding site 278137005418 putative DNA binding helix; other site 278137005419 metal binding site 1 [ion binding]; metal-binding site 278137005420 dimer interface [polypeptide binding]; other site 278137005421 structural Zn2+ binding site [ion binding]; other site 278137005422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137005423 dimerization interface [polypeptide binding]; other site 278137005424 putative DNA binding site [nucleotide binding]; other site 278137005425 putative Zn2+ binding site [ion binding]; other site 278137005426 glycyl-tRNA synthetase; Provisional; Region: PRK04173 278137005427 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 278137005428 motif 1; other site 278137005429 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 278137005430 active site 278137005431 motif 2; other site 278137005432 motif 3; other site 278137005433 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 278137005434 anticodon binding site; other site 278137005435 Repair protein; Region: Repair_PSII; cl01535 278137005436 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 278137005437 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 278137005438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278137005439 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 278137005440 DNA primase; Validated; Region: dnaG; PRK05667 278137005441 CHC2 zinc finger; Region: zf-CHC2; cl15369 278137005442 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 278137005443 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 278137005444 active site 278137005445 metal binding site [ion binding]; metal-binding site 278137005446 interdomain interaction site; other site 278137005447 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 278137005448 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 278137005449 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 278137005450 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137005451 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137005452 active site 278137005453 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 278137005454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137005455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137005456 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278137005457 Helix-turn-helix domains; Region: HTH; cl00088 278137005458 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 278137005459 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 278137005460 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 278137005461 Walker A/P-loop; other site 278137005462 ATP binding site [chemical binding]; other site 278137005463 Q-loop/lid; other site 278137005464 ABC transporter signature motif; other site 278137005465 Walker B; other site 278137005466 D-loop; other site 278137005467 H-loop/switch region; other site 278137005468 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 278137005469 Walker A/P-loop; other site 278137005470 ATP binding site [chemical binding]; other site 278137005471 Q-loop/lid; other site 278137005472 ABC transporter signature motif; other site 278137005473 Walker B; other site 278137005474 D-loop; other site 278137005475 H-loop/switch region; other site 278137005476 Cobalt transport protein; Region: CbiQ; cl00463 278137005477 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 278137005478 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 278137005479 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 278137005480 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 278137005481 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137005482 metal binding site [ion binding]; metal-binding site 278137005483 active site 278137005484 I-site; other site 278137005485 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137005486 NMT1-like family; Region: NMT1_2; cl15260 278137005487 GAF domain; Region: GAF_2; pfam13185 278137005488 GAF domain; Region: GAF; cl15785 278137005489 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 278137005490 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 278137005491 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cd01901 278137005492 active site 278137005493 Mechanosensitive ion channel; Region: MS_channel; pfam00924 278137005494 Domain of unknown function (DUF427); Region: DUF427; cl00998 278137005495 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 278137005496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 278137005497 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 278137005498 putative active site [active] 278137005499 putative metal binding site [ion binding]; other site 278137005500 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 278137005501 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137005502 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137005503 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 278137005504 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 278137005505 active site 278137005506 Zn binding site [ion binding]; other site 278137005507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137005508 AzlC protein; Region: AzlC; cl00570 278137005509 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 278137005510 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 278137005511 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137005512 iron-sulfur cluster [ion binding]; other site 278137005513 [2Fe-2S] cluster binding site [ion binding]; other site 278137005514 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137005515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005516 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137005517 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137005518 active site 278137005519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 278137005520 Transposase; Region: DDE_Tnp_ISL3; pfam01610 278137005521 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137005522 classical (c) SDRs; Region: SDR_c; cd05233 278137005523 NAD(P) binding site [chemical binding]; other site 278137005524 active site 278137005525 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 278137005526 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 278137005527 Walker A/P-loop; other site 278137005528 ATP binding site [chemical binding]; other site 278137005529 Q-loop/lid; other site 278137005530 ABC transporter signature motif; other site 278137005531 Walker B; other site 278137005532 D-loop; other site 278137005533 H-loop/switch region; other site 278137005534 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 278137005535 Walker A/P-loop; other site 278137005536 ATP binding site [chemical binding]; other site 278137005537 Q-loop/lid; other site 278137005538 ABC transporter signature motif; other site 278137005539 Walker B; other site 278137005540 D-loop; other site 278137005541 H-loop/switch region; other site 278137005542 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 278137005543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137005544 putative PBP binding loops; other site 278137005545 dimer interface [polypeptide binding]; other site 278137005546 ABC-ATPase subunit interface; other site 278137005547 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 278137005548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137005549 dimer interface [polypeptide binding]; other site 278137005550 conserved gate region; other site 278137005551 putative PBP binding loops; other site 278137005552 ABC-ATPase subunit interface; other site 278137005553 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 278137005554 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 278137005555 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137005556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005557 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 278137005558 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137005559 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 278137005560 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 278137005561 NAD binding site [chemical binding]; other site 278137005562 catalytic Zn binding site [ion binding]; other site 278137005563 substrate binding site [chemical binding]; other site 278137005564 structural Zn binding site [ion binding]; other site 278137005565 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 278137005566 putative active site [active] 278137005567 metal binding site [ion binding]; metal-binding site 278137005568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137005569 S-adenosylmethionine binding site [chemical binding]; other site 278137005570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137005571 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 278137005572 diacylglycerol kinase; Reviewed; Region: PRK11914 278137005573 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 278137005574 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 278137005575 FAD binding domain; Region: FAD_binding_4; pfam01565 278137005576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137005577 Helix-turn-helix domains; Region: HTH; cl00088 278137005578 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 278137005579 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137005580 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 278137005581 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137005582 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 278137005583 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 278137005584 dimer interface [polypeptide binding]; other site 278137005585 active site 278137005586 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 278137005587 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 278137005588 dimer interface [polypeptide binding]; other site 278137005589 active site 278137005590 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137005591 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137005592 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 278137005593 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 278137005594 Helix-turn-helix domains; Region: HTH; cl00088 278137005595 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 278137005596 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 278137005597 dimer interface [polypeptide binding]; other site 278137005598 TPP-binding site [chemical binding]; other site 278137005599 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 278137005600 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 278137005601 dimer interface [polypeptide binding]; other site 278137005602 catalytic triad [active] 278137005603 MASE1; Region: MASE1; pfam05231 278137005604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 278137005605 PAS domain; Region: PAS_9; pfam13426 278137005606 putative active site [active] 278137005607 heme pocket [chemical binding]; other site 278137005608 PAS domain S-box; Region: sensory_box; TIGR00229 278137005609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 278137005610 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137005611 metal binding site [ion binding]; metal-binding site 278137005612 active site 278137005613 I-site; other site 278137005614 SOUL heme-binding protein; Region: SOUL; pfam04832 278137005615 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 278137005616 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137005617 active site 278137005618 CobD/Cbib protein; Region: CobD_Cbib; cl00561 278137005619 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 278137005620 Low molecular weight phosphatase family; Region: LMWPc; cd00115 278137005621 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 278137005622 active site 278137005623 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 278137005624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137005625 motif II; other site 278137005626 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 278137005627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 278137005628 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 278137005629 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 278137005630 Putative zinc ribbon domain; Region: DUF164; pfam02591 278137005631 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 278137005632 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 278137005633 active site 278137005634 RNA/DNA hybrid binding site [nucleotide binding]; other site 278137005635 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137005636 catalytic core [active] 278137005637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137005638 sequence-specific DNA binding site [nucleotide binding]; other site 278137005639 salt bridge; other site 278137005640 Cupin domain; Region: Cupin_2; cl09118 278137005641 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 278137005642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137005643 S-adenosylmethionine binding site [chemical binding]; other site 278137005644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137005645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278137005646 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 278137005647 putative active site; other site 278137005648 putative metal binding residues [ion binding]; other site 278137005649 signature motif; other site 278137005650 putative triphosphate binding site [ion binding]; other site 278137005651 CHAD domain; Region: CHAD; cl10506 278137005652 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 278137005653 AMP-binding enzyme; Region: AMP-binding; cl15778 278137005654 enoyl-CoA hydratase; Provisional; Region: PRK08140 278137005655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137005656 substrate binding site [chemical binding]; other site 278137005657 oxyanion hole (OAH) forming residues; other site 278137005658 trimer interface [polypeptide binding]; other site 278137005659 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 278137005660 oligomerization interface [polypeptide binding]; other site 278137005661 active site 278137005662 metal binding site [ion binding]; metal-binding site 278137005663 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 278137005664 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137005665 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278137005666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137005667 Coenzyme A binding pocket [chemical binding]; other site 278137005668 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 278137005669 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137005670 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 278137005671 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 278137005672 active site 278137005673 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 278137005674 catalytic triad [active] 278137005675 dimer interface [polypeptide binding]; other site 278137005676 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278137005677 active site 278137005678 metal binding site [ion binding]; metal-binding site 278137005679 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 278137005680 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 278137005681 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 278137005682 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 278137005683 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 278137005684 metal binding triad; other site 278137005685 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 278137005686 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 278137005687 metal binding triad; other site 278137005688 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 278137005689 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137005690 CoenzymeA binding site [chemical binding]; other site 278137005691 subunit interaction site [polypeptide binding]; other site 278137005692 PHB binding site; other site 278137005693 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137005694 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 278137005695 structural tetrad; other site 278137005696 PQQ-like domain; Region: PQQ_2; pfam13360 278137005697 DoxX; Region: DoxX; cl00976 278137005698 glutamine synthetase, type I; Region: GlnA; TIGR00653 278137005699 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 278137005700 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 278137005701 RDD family; Region: RDD; cl00746 278137005702 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137005703 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137005704 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 278137005705 lipoyl synthase; Provisional; Region: PRK05481 278137005706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137005707 FeS/SAM binding site; other site 278137005708 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 278137005709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005710 TIGR01777 family protein; Region: yfcH 278137005711 NAD(P) binding site [chemical binding]; other site 278137005712 active site 278137005713 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 278137005714 E3 interaction surface; other site 278137005715 lipoyl attachment site [posttranslational modification]; other site 278137005716 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 278137005717 E3 interaction surface; other site 278137005718 lipoyl attachment site [posttranslational modification]; other site 278137005719 e3 binding domain; Region: E3_binding; pfam02817 278137005720 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 278137005721 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 278137005722 short chain dehydrogenase; Validated; Region: PRK05855 278137005723 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278137005724 classical (c) SDRs; Region: SDR_c; cd05233 278137005725 NAD(P) binding site [chemical binding]; other site 278137005726 active site 278137005727 multifunctional aminopeptidase A; Provisional; Region: PRK00913 278137005728 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 278137005729 interface (dimer of trimers) [polypeptide binding]; other site 278137005730 Substrate-binding/catalytic site; other site 278137005731 Zn-binding sites [ion binding]; other site 278137005732 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 278137005733 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 278137005734 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 278137005735 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 278137005736 homodimer interface [polypeptide binding]; other site 278137005737 substrate-cofactor binding pocket; other site 278137005738 catalytic residue [active] 278137005739 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 278137005740 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 278137005741 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 278137005742 putative dimer interface [polypeptide binding]; other site 278137005743 active site pocket [active] 278137005744 putative cataytic base [active] 278137005745 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 278137005746 Glycerate kinase family; Region: Gly_kinase; cl00841 278137005747 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 278137005748 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 278137005749 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 278137005750 substrate binding site [chemical binding]; other site 278137005751 ATP binding site [chemical binding]; other site 278137005752 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 278137005753 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 278137005754 dimer interface [polypeptide binding]; other site 278137005755 active site 278137005756 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 278137005757 Ligand Binding Site [chemical binding]; other site 278137005758 Molecular Tunnel; other site 278137005759 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 278137005760 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137005761 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 278137005762 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 278137005763 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 278137005764 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 278137005765 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 278137005766 heme bH binding site [chemical binding]; other site 278137005767 intrachain domain interface; other site 278137005768 heme bL binding site [chemical binding]; other site 278137005769 interchain domain interface [polypeptide binding]; other site 278137005770 Qo binding site; other site 278137005771 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 278137005772 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 278137005773 iron-sulfur cluster [ion binding]; other site 278137005774 [2Fe-2S] cluster binding site [ion binding]; other site 278137005775 Cytochrome c; Region: Cytochrom_C; cl11414 278137005776 Cytochrome c; Region: Cytochrom_C; cl11414 278137005777 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 278137005778 Subunit I/III interface [polypeptide binding]; other site 278137005779 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 278137005780 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 278137005781 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 278137005782 hypothetical protein; Validated; Region: PRK07883 278137005783 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 278137005784 active site 278137005785 catalytic site [active] 278137005786 substrate binding site [chemical binding]; other site 278137005787 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 278137005788 GIY-YIG motif/motif A; other site 278137005789 active site 278137005790 catalytic site [active] 278137005791 putative DNA binding site [nucleotide binding]; other site 278137005792 metal binding site [ion binding]; metal-binding site 278137005793 NlpC/P60 family; Region: NLPC_P60; cl11438 278137005794 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 278137005795 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137005796 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137005797 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 278137005798 AMP-binding enzyme; Region: AMP-binding; cl15778 278137005799 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 278137005800 putative hydrophobic ligand binding site [chemical binding]; other site 278137005801 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 278137005802 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 278137005803 P loop; other site 278137005804 Nucleotide binding site [chemical binding]; other site 278137005805 DTAP/Switch II; other site 278137005806 Switch I; other site 278137005807 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 278137005808 putative acyl-acceptor binding pocket; other site 278137005809 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 278137005810 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 278137005811 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137005812 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137005813 active site 278137005814 ATP binding site [chemical binding]; other site 278137005815 substrate binding site [chemical binding]; other site 278137005816 activation loop (A-loop); other site 278137005817 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278137005818 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 278137005819 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 278137005820 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 278137005821 substrate binding pocket [chemical binding]; other site 278137005822 chain length determination region; other site 278137005823 substrate-Mg2+ binding site; other site 278137005824 catalytic residues [active] 278137005825 aspartate-rich region 1; other site 278137005826 active site lid residues [active] 278137005827 aspartate-rich region 2; other site 278137005828 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 278137005829 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 278137005830 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137005831 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 278137005832 cell division protein MraZ; Reviewed; Region: PRK00326 278137005833 MraZ protein; Region: MraZ; pfam02381 278137005834 MraZ protein; Region: MraZ; pfam02381 278137005835 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 278137005836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137005837 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 278137005838 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 278137005839 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137005840 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 278137005841 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278137005842 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278137005843 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278137005844 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 278137005845 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278137005846 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 278137005847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278137005848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278137005849 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 278137005850 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 278137005851 Mg++ binding site [ion binding]; other site 278137005852 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 278137005853 putative catalytic motif [active] 278137005854 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 278137005855 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278137005856 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278137005857 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 278137005858 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 278137005859 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 278137005860 active site 278137005861 homodimer interface [polypeptide binding]; other site 278137005862 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 278137005863 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278137005864 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278137005865 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278137005866 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 278137005867 Cell division protein FtsQ; Region: FtsQ; pfam03799 278137005868 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 278137005869 nucleotide binding site [chemical binding]; other site 278137005870 SulA interaction site; other site 278137005871 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 278137005872 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 278137005873 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 278137005874 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 278137005875 catalytic residue [active] 278137005876 Protein of unknown function (DUF552); Region: DUF552; cl00775 278137005877 YGGT family; Region: YGGT; cl00508 278137005878 DivIVA domain; Region: DivI1A_domain; TIGR03544 278137005879 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 278137005880 Plant ATP synthase F0; Region: YMF19; cl07975 278137005881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137005882 active site 278137005883 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 278137005884 putative hydrophobic ligand binding site [chemical binding]; other site 278137005885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137005886 TIGR01777 family protein; Region: yfcH 278137005887 NAD(P) binding site [chemical binding]; other site 278137005888 active site 278137005889 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 278137005890 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 278137005891 catalytic triad [active] 278137005892 Calx-beta domain; Region: Calx-beta; cl02522 278137005893 Calx-beta domain; Region: Calx-beta; cl02522 278137005894 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 278137005895 active site 278137005896 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 278137005897 Calx-beta domain; Region: Calx-beta; cl02522 278137005898 Cellulose binding domain; Region: CBM_2; cl02709 278137005899 Calx-beta domain; Region: Calx-beta; cl02522 278137005900 Cellulose binding domain; Region: CBM_2; cl02709 278137005901 Calx-beta domain; Region: Calx-beta; cl02522 278137005902 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 278137005903 Calx-beta domain; Region: Calx-beta; cl02522 278137005904 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 278137005905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137005906 active site 278137005907 phosphorylation site [posttranslational modification] 278137005908 intermolecular recognition site; other site 278137005909 dimerization interface [polypeptide binding]; other site 278137005910 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 278137005911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137005912 ATP binding site [chemical binding]; other site 278137005913 Mg2+ binding site [ion binding]; other site 278137005914 G-X-G motif; other site 278137005915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 278137005916 NMT1-like family; Region: NMT1_2; cl15260 278137005917 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 278137005918 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 278137005919 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137005920 Ligand Binding Site [chemical binding]; other site 278137005921 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137005922 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 278137005923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137005924 Helix-turn-helix domains; Region: HTH; cl00088 278137005925 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137005926 iron-sulfur cluster [ion binding]; other site 278137005927 [2Fe-2S] cluster binding site [ion binding]; other site 278137005928 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 278137005929 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137005930 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 278137005931 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 278137005932 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 278137005933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137005934 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 278137005935 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 278137005936 [4Fe-4S] binding site [ion binding]; other site 278137005937 molybdopterin cofactor binding site; other site 278137005938 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 278137005939 molybdopterin cofactor binding site; other site 278137005940 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 278137005941 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278137005942 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 278137005943 FAD binding pocket [chemical binding]; other site 278137005944 FAD binding motif [chemical binding]; other site 278137005945 catalytic residues [active] 278137005946 NAD binding pocket [chemical binding]; other site 278137005947 phosphate binding motif [ion binding]; other site 278137005948 beta-alpha-beta structure motif; other site 278137005949 Acyltransferase family; Region: Acyl_transf_3; pfam01757 278137005950 hypothetical protein; Provisional; Region: PRK07906 278137005951 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 278137005952 putative metal binding site [ion binding]; other site 278137005953 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 278137005954 substrate binding site [chemical binding]; other site 278137005955 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 278137005956 quinone interaction residues [chemical binding]; other site 278137005957 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 278137005958 active site 278137005959 catalytic residues [active] 278137005960 FMN binding site [chemical binding]; other site 278137005961 substrate binding site [chemical binding]; other site 278137005962 Bacitracin resistance protein BacA; Region: BacA; cl00858 278137005963 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137005964 catalytic core [active] 278137005965 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 278137005966 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 278137005967 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 278137005968 active site 278137005969 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 278137005970 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 278137005971 active site 278137005972 HIGH motif; other site 278137005973 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278137005974 active site 278137005975 KMSKS motif; other site 278137005976 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 278137005977 putative tRNA binding surface [nucleotide binding]; other site 278137005978 short chain dehydrogenase; Provisional; Region: PRK05872 278137005979 classical (c) SDRs; Region: SDR_c; cd05233 278137005980 NAD(P) binding site [chemical binding]; other site 278137005981 active site 278137005982 Uncharacterized conserved protein [Function unknown]; Region: COG5361 278137005983 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 278137005984 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 278137005985 PAC2 family; Region: PAC2; cl00847 278137005986 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 278137005987 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 278137005988 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 278137005989 substrate binding pocket [chemical binding]; other site 278137005990 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 278137005991 B12 binding site [chemical binding]; other site 278137005992 cobalt ligand [ion binding]; other site 278137005993 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 278137005994 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 278137005995 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137005996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137005997 motif II; other site 278137005998 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 278137005999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137006000 putative substrate translocation pore; other site 278137006001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137006002 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 278137006003 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 278137006004 ATP phosphoribosyltransferase; Region: HisG; cl15266 278137006005 HisG, C-terminal domain; Region: HisG_C; cl06867 278137006006 Predicted membrane protein [Function unknown]; Region: COG3918 278137006007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137006008 Helix-turn-helix domains; Region: HTH; cl00088 278137006009 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 278137006010 active site 278137006011 diiron metal binding site [ion binding]; other site 278137006012 DinB superfamily; Region: DinB_2; pfam12867 278137006013 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 278137006014 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 278137006015 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 278137006016 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 278137006017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137006018 S-adenosylmethionine binding site [chemical binding]; other site 278137006019 Protein of unknown function (DUF503); Region: DUF503; cl00669 278137006020 proteasome ATPase; Region: pup_AAA; TIGR03689 278137006021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137006022 Walker A motif; other site 278137006023 ATP binding site [chemical binding]; other site 278137006024 Walker B motif; other site 278137006025 arginine finger; other site 278137006026 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 278137006027 Rrf2 family protein; Region: rrf2_super; TIGR00738 278137006028 Helix-turn-helix domains; Region: HTH; cl00088 278137006029 Pup-ligase protein; Region: Pup_ligase; cl15463 278137006030 Pup-like protein; Region: Pup; cl05289 278137006031 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 278137006032 active site 278137006033 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 278137006034 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 278137006035 active site 278137006036 FAD dependent oxidoreductase; Region: DAO; pfam01266 278137006037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137006038 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 278137006039 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 278137006040 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 278137006041 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 278137006042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006043 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 278137006044 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 278137006045 [2Fe-2S] cluster binding site [ion binding]; other site 278137006046 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137006047 hydrophobic ligand binding site; other site 278137006048 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 278137006049 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137006050 tetramerization interface [polypeptide binding]; other site 278137006051 NAD(P) binding site [chemical binding]; other site 278137006052 catalytic residues [active] 278137006053 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 278137006054 Spore germination protein; Region: Spore_permease; cl15802 278137006055 choline dehydrogenase; Validated; Region: PRK02106 278137006056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006057 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 278137006058 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 278137006059 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 278137006060 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 278137006061 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 278137006062 metal binding triad; other site 278137006063 Transcriptional regulator [Transcription]; Region: IclR; COG1414 278137006064 Helix-turn-helix domains; Region: HTH; cl00088 278137006065 Bacterial transcriptional regulator; Region: IclR; pfam01614 278137006066 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 278137006067 Pup-ligase protein; Region: Pup_ligase; cl15463 278137006068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137006069 S-adenosylmethionine binding site [chemical binding]; other site 278137006070 Predicted transcriptional regulator [Transcription]; Region: COG2378 278137006071 WYL domain; Region: WYL; cl14852 278137006072 Predicted transcriptional regulator [Transcription]; Region: COG2378 278137006073 WYL domain; Region: WYL; cl14852 278137006074 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 278137006075 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 278137006076 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 278137006077 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137006078 ATP binding site [chemical binding]; other site 278137006079 putative Mg++ binding site [ion binding]; other site 278137006080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137006081 nucleotide binding region [chemical binding]; other site 278137006082 ATP-binding site [chemical binding]; other site 278137006083 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 278137006084 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 278137006085 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 278137006086 5'-3' exonuclease; Region: 53EXOc; smart00475 278137006087 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 278137006088 active site 278137006089 metal binding site 1 [ion binding]; metal-binding site 278137006090 putative 5' ssDNA interaction site; other site 278137006091 metal binding site 3; metal-binding site 278137006092 metal binding site 2 [ion binding]; metal-binding site 278137006093 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 278137006094 putative DNA binding site [nucleotide binding]; other site 278137006095 putative metal binding site [ion binding]; other site 278137006096 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 278137006097 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 278137006098 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 278137006099 active site 278137006100 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137006101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006102 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278137006103 NAD(P) binding site [chemical binding]; other site 278137006104 active site 278137006105 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278137006106 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 278137006107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137006108 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 278137006109 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137006110 substrate binding site [chemical binding]; other site 278137006111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137006112 Helix-turn-helix domains; Region: HTH; cl00088 278137006113 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278137006114 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 278137006115 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278137006116 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 278137006117 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 278137006118 Precorrin-8X methylmutase; Region: CbiC; pfam02570 278137006119 precorrin-3B synthase; Region: CobG; TIGR02435 278137006120 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 278137006121 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 278137006122 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 278137006123 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 278137006124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137006125 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 278137006126 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 278137006127 Walker A/P-loop; other site 278137006128 ATP binding site [chemical binding]; other site 278137006129 Q-loop/lid; other site 278137006130 ABC transporter signature motif; other site 278137006131 Walker B; other site 278137006132 D-loop; other site 278137006133 H-loop/switch region; other site 278137006134 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 278137006135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137006136 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 278137006137 NMT1-like family; Region: NMT1_2; cl15260 278137006138 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 278137006139 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 278137006140 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 278137006141 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137006142 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137006143 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 278137006144 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 278137006145 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137006146 active site 278137006147 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 278137006148 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 278137006149 putative active site [active] 278137006150 catalytic triad [active] 278137006151 putative dimer interface [polypeptide binding]; other site 278137006152 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 278137006153 Ligand binding site; other site 278137006154 Putative Catalytic site; other site 278137006155 DXD motif; other site 278137006156 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 278137006157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137006158 DNA binding site [nucleotide binding] 278137006159 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137006160 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137006161 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 278137006162 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137006163 substrate binding pocket [chemical binding]; other site 278137006164 catalytic triad [active] 278137006165 tyramine oxidase; Provisional; Region: tynA; PRK11504 278137006166 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 278137006167 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 278137006168 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 278137006169 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 278137006170 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 278137006171 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 278137006172 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 278137006173 DoxX; Region: DoxX; cl00976 278137006174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137006175 enoyl-CoA hydratase; Provisional; Region: PRK08260 278137006176 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137006177 substrate binding site [chemical binding]; other site 278137006178 oxyanion hole (OAH) forming residues; other site 278137006179 trimer interface [polypeptide binding]; other site 278137006180 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 278137006181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137006182 dimer interface [polypeptide binding]; other site 278137006183 conserved gate region; other site 278137006184 putative PBP binding loops; other site 278137006185 ABC-ATPase subunit interface; other site 278137006186 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 278137006187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137006188 dimer interface [polypeptide binding]; other site 278137006189 conserved gate region; other site 278137006190 putative PBP binding loops; other site 278137006191 ABC-ATPase subunit interface; other site 278137006192 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 278137006193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137006194 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 278137006195 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 278137006196 Walker A/P-loop; other site 278137006197 ATP binding site [chemical binding]; other site 278137006198 Q-loop/lid; other site 278137006199 ABC transporter signature motif; other site 278137006200 Walker B; other site 278137006201 D-loop; other site 278137006202 H-loop/switch region; other site 278137006203 TOBE domain; Region: TOBE_2; cl01440 278137006204 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 278137006205 hydrophobic ligand binding site; other site 278137006206 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278137006207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 278137006208 TspO/MBR family; Region: TspO_MBR; cl01379 278137006209 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 278137006210 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 278137006211 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 278137006212 FAD binding pocket [chemical binding]; other site 278137006213 FAD binding motif [chemical binding]; other site 278137006214 phosphate binding motif [ion binding]; other site 278137006215 NAD binding pocket [chemical binding]; other site 278137006216 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137006217 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 278137006218 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137006219 NAD binding site [chemical binding]; other site 278137006220 catalytic Zn binding site [ion binding]; other site 278137006221 structural Zn binding site [ion binding]; other site 278137006222 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 278137006223 hydrophobic ligand binding site; other site 278137006224 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 278137006225 amidase catalytic site [active] 278137006226 Zn binding residues [ion binding]; other site 278137006227 substrate binding site [chemical binding]; other site 278137006228 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 278137006229 Helix-turn-helix domains; Region: HTH; cl00088 278137006230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006231 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 278137006232 NAD(P) binding site [chemical binding]; other site 278137006233 active site 278137006234 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137006235 active site 278137006236 substrate binding site [chemical binding]; other site 278137006237 ATP binding site [chemical binding]; other site 278137006238 Phosphotransferase enzyme family; Region: APH; pfam01636 278137006239 Ferredoxin [Energy production and conversion]; Region: COG1146 278137006240 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 278137006241 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 278137006242 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 278137006243 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 278137006244 Walker A/P-loop; other site 278137006245 ATP binding site [chemical binding]; other site 278137006246 Q-loop/lid; other site 278137006247 ABC transporter signature motif; other site 278137006248 Walker B; other site 278137006249 D-loop; other site 278137006250 H-loop/switch region; other site 278137006251 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 278137006252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137006253 dimer interface [polypeptide binding]; other site 278137006254 conserved gate region; other site 278137006255 putative PBP binding loops; other site 278137006256 ABC-ATPase subunit interface; other site 278137006257 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 278137006258 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137006259 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 278137006260 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137006261 dimerization interface [polypeptide binding]; other site 278137006262 putative DNA binding site [nucleotide binding]; other site 278137006263 putative Zn2+ binding site [ion binding]; other site 278137006264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006265 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137006266 NAD(P) binding site [chemical binding]; other site 278137006267 active site 278137006268 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278137006269 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137006270 substrate binding pocket [chemical binding]; other site 278137006271 membrane-bound complex binding site; other site 278137006272 hinge residues; other site 278137006273 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278137006274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137006275 dimer interface [polypeptide binding]; other site 278137006276 conserved gate region; other site 278137006277 putative PBP binding loops; other site 278137006278 ABC-ATPase subunit interface; other site 278137006279 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278137006280 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 278137006281 Walker A/P-loop; other site 278137006282 ATP binding site [chemical binding]; other site 278137006283 Q-loop/lid; other site 278137006284 ABC transporter signature motif; other site 278137006285 Walker B; other site 278137006286 D-loop; other site 278137006287 H-loop/switch region; other site 278137006288 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 278137006289 ABC-ATPase subunit interface; other site 278137006290 dimer interface [polypeptide binding]; other site 278137006291 putative PBP binding regions; other site 278137006292 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 278137006293 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 278137006294 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 278137006295 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 278137006296 metal binding site [ion binding]; metal-binding site 278137006297 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 278137006298 Na binding site [ion binding]; other site 278137006299 putative substrate binding site [chemical binding]; other site 278137006300 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 278137006301 hypothetical protein; Provisional; Region: PRK11171 278137006302 Cupin domain; Region: Cupin_2; cl09118 278137006303 Cupin domain; Region: Cupin_2; cl09118 278137006304 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137006305 Transcriptional regulator [Transcription]; Region: IclR; COG1414 278137006306 Helix-turn-helix domains; Region: HTH; cl00088 278137006307 Bacterial transcriptional regulator; Region: IclR; pfam01614 278137006308 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 278137006309 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 278137006310 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137006311 catalytic residue [active] 278137006312 Cutinase; Region: Cutinase; pfam01083 278137006313 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137006314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137006315 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 278137006316 Cadmium resistance transporter; Region: Cad; pfam03596 278137006317 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 278137006318 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 278137006319 DNA binding residues [nucleotide binding] 278137006320 dimer interface [polypeptide binding]; other site 278137006321 metal binding site [ion binding]; metal-binding site 278137006322 mercuric reductase; Region: MerA; TIGR02053 278137006323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137006324 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278137006325 alkylmercury lyase; Provisional; Region: PRK13239 278137006326 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 278137006327 Alkylmercury lyase; Region: MerB; pfam03243 278137006328 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 278137006329 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 278137006330 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 278137006331 Helix-turn-helix domains; Region: HTH; cl00088 278137006332 Winged helix-turn helix; Region: HTH_29; pfam13551 278137006333 Helix-turn-helix domains; Region: HTH; cl00088 278137006334 Integrase core domain; Region: rve; cl01316 278137006335 Integrase core domain; Region: rve_3; cl15866 278137006336 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 278137006337 Helix-turn-helix domains; Region: HTH; cl00088 278137006338 Integrase core domain; Region: rve; cl01316 278137006339 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 278137006340 putative transposase OrfB; Reviewed; Region: PHA02517 278137006341 Integrase core domain; Region: rve; cl01316 278137006342 Integrase core domain; Region: rve_3; cl15866 278137006343 Helix-turn-helix domains; Region: HTH; cl00088 278137006344 putative transposase OrfB; Reviewed; Region: PHA02517 278137006345 HTH-like domain; Region: HTH_21; pfam13276 278137006346 Integrase core domain; Region: rve; cl01316 278137006347 Integrase core domain; Region: rve_3; cl15866 278137006348 Helix-turn-helix domains; Region: HTH; cl00088 278137006349 Integrase core domain; Region: rve; cl01316 278137006350 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 278137006351 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137006352 TniQ; Region: TniQ; pfam06527 278137006353 Cadmium resistance transporter; Region: Cad; pfam03596 278137006354 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 278137006355 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137006356 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137006357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137006358 dimerization interface [polypeptide binding]; other site 278137006359 putative DNA binding site [nucleotide binding]; other site 278137006360 putative Zn2+ binding site [ion binding]; other site 278137006361 Helix-turn-helix domains; Region: HTH; cl00088 278137006362 HTH-like domain; Region: HTH_21; pfam13276 278137006363 Integrase core domain; Region: rve; cl01316 278137006364 Integrase core domain; Region: rve_3; cl15866 278137006365 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137006366 HTH-like domain; Region: HTH_21; pfam13276 278137006367 Integrase core domain; Region: rve; cl01316 278137006368 Integrase core domain; Region: rve_3; cl15866 278137006369 Helix-turn-helix domains; Region: HTH; cl00088 278137006370 HTH-like domain; Region: HTH_21; pfam13276 278137006371 Integrase core domain; Region: rve; cl01316 278137006372 Integrase core domain; Region: rve_3; cl15866 278137006373 Helix-turn-helix domains; Region: HTH; cl00088 278137006374 putative transposase OrfB; Reviewed; Region: PHA02517 278137006375 HTH-like domain; Region: HTH_21; pfam13276 278137006376 Integrase core domain; Region: rve; cl01316 278137006377 Integrase core domain; Region: rve_3; cl15866 278137006378 Helix-turn-helix domains; Region: HTH; cl00088 278137006379 putative transposase OrfB; Reviewed; Region: PHA02517 278137006380 HTH-like domain; Region: HTH_21; pfam13276 278137006381 Integrase core domain; Region: rve; cl01316 278137006382 Integrase core domain; Region: rve_3; cl15866 278137006383 cyclase homology domain; Region: CHD; cd07302 278137006384 nucleotidyl binding site; other site 278137006385 metal binding site [ion binding]; metal-binding site 278137006386 dimer interface [polypeptide binding]; other site 278137006387 cyclase homology domain; Region: CHD; cd07302 278137006388 nucleotidyl binding site; other site 278137006389 metal binding site [ion binding]; metal-binding site 278137006390 dimer interface [polypeptide binding]; other site 278137006391 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 278137006392 Int/Topo IB signature motif; other site 278137006393 DNA binding site [nucleotide binding] 278137006394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137006395 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 278137006396 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137006397 active site 278137006398 DNA binding site [nucleotide binding] 278137006399 Int/Topo IB signature motif; other site 278137006400 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 278137006401 Integrase core domain; Region: rve; cl01316 278137006402 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 278137006403 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 278137006404 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137006405 ATP binding site [chemical binding]; other site 278137006406 putative Mg++ binding site [ion binding]; other site 278137006407 HsdM N-terminal domain; Region: HsdM_N; pfam12161 278137006408 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 278137006409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137006410 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 278137006411 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 278137006412 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 278137006413 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 278137006414 active site 278137006415 NTP binding site [chemical binding]; other site 278137006416 metal binding triad [ion binding]; metal-binding site 278137006417 Helix-turn-helix domains; Region: HTH; cl00088 278137006418 HTH-like domain; Region: HTH_21; pfam13276 278137006419 Integrase core domain; Region: rve; cl01316 278137006420 Integrase core domain; Region: rve_3; cl15866 278137006421 HTH-like domain; Region: HTH_21; pfam13276 278137006422 Integrase core domain; Region: rve; cl01316 278137006423 Integrase core domain; Region: rve_3; cl15866 278137006424 Helix-turn-helix domains; Region: HTH; cl00088 278137006425 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 278137006426 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137006427 MULE transposase domain; Region: MULE; pfam10551 278137006428 Helix-turn-helix domains; Region: HTH; cl00088 278137006429 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137006430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006431 YaeQ protein; Region: YaeQ; cl01913 278137006432 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 278137006433 putative hydrophobic ligand binding site [chemical binding]; other site 278137006434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137006435 dimerization interface [polypeptide binding]; other site 278137006436 putative DNA binding site [nucleotide binding]; other site 278137006437 putative Zn2+ binding site [ion binding]; other site 278137006438 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 278137006439 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137006440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137006441 Helix-turn-helix domains; Region: HTH; cl00088 278137006442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278137006443 RNA binding surface [nucleotide binding]; other site 278137006444 Predicted esterase [General function prediction only]; Region: COG0627 278137006445 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137006446 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 278137006447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137006448 S-adenosylmethionine binding site [chemical binding]; other site 278137006449 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137006450 DinB superfamily; Region: DinB_2; pfam12867 278137006451 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 278137006452 AMP-binding enzyme; Region: AMP-binding; cl15778 278137006453 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 278137006454 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137006455 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137006456 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 278137006457 putative active site [active] 278137006458 PE-PPE domain; Region: PE-PPE; pfam08237 278137006459 NlpC/P60 family; Region: NLPC_P60; cl11438 278137006460 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 278137006461 dimer interface [polypeptide binding]; other site 278137006462 catalytic triad [active] 278137006463 peroxidatic and resolving cysteines [active] 278137006464 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 278137006465 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 278137006466 hypothetical protein; Validated; Region: PRK07198 278137006467 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 278137006468 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 278137006469 dimerization interface [polypeptide binding]; other site 278137006470 active site 278137006471 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 278137006472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137006473 active site 278137006474 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 278137006475 tetramer interface [polypeptide binding]; other site 278137006476 active site 278137006477 Mg2+/Mn2+ binding site [ion binding]; other site 278137006478 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 278137006479 O-succinylbenzoate synthase; Provisional; Region: PRK02901 278137006480 O-succinylbenzoate synthase; Provisional; Region: PRK02901 278137006481 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 278137006482 catalytic triad [active] 278137006483 Arterivirus envelope protein; Region: Arteri_env; pfam01606 278137006484 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 278137006485 apolar tunnel; other site 278137006486 heme binding site [chemical binding]; other site 278137006487 dimerization interface [polypeptide binding]; other site 278137006488 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 278137006489 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 278137006490 active site 278137006491 catalytic triad [active] 278137006492 oxyanion hole [active] 278137006493 OpgC protein; Region: OpgC_C; cl00792 278137006494 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 278137006495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137006496 active site 278137006497 phosphorylation site [posttranslational modification] 278137006498 intermolecular recognition site; other site 278137006499 dimerization interface [polypeptide binding]; other site 278137006500 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 278137006501 CHASE3 domain; Region: CHASE3; cl05000 278137006502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137006503 dimer interface [polypeptide binding]; other site 278137006504 phosphorylation site [posttranslational modification] 278137006505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137006506 ATP binding site [chemical binding]; other site 278137006507 Mg2+ binding site [ion binding]; other site 278137006508 G-X-G motif; other site 278137006509 Response regulator receiver domain; Region: Response_reg; pfam00072 278137006510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137006511 active site 278137006512 phosphorylation site [posttranslational modification] 278137006513 intermolecular recognition site; other site 278137006514 dimerization interface [polypeptide binding]; other site 278137006515 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 278137006516 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 278137006517 NlpC/P60 family; Region: NLPC_P60; cl11438 278137006518 Protein of unknown function (DUF328); Region: DUF328; cl01143 278137006519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137006520 competence damage-inducible protein A; Provisional; Region: PRK00549 278137006521 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 278137006522 Competence-damaged protein; Region: CinA; cl00666 278137006523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006524 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137006525 NAD(P) binding site [chemical binding]; other site 278137006526 active site 278137006527 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137006528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006529 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 278137006530 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137006531 anti sigma factor interaction site; other site 278137006532 regulatory phosphorylation site [posttranslational modification]; other site 278137006533 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 278137006534 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137006535 Nitronate monooxygenase; Region: NMO; pfam03060 278137006536 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137006537 FMN binding site [chemical binding]; other site 278137006538 substrate binding site [chemical binding]; other site 278137006539 putative catalytic residue [active] 278137006540 Helix-turn-helix domains; Region: HTH; cl00088 278137006541 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 278137006542 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137006543 molybdopterin cofactor binding site; other site 278137006544 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137006545 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 278137006546 molybdopterin cofactor binding site; other site 278137006547 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137006548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137006549 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 278137006550 acyl-CoA synthetase; Validated; Region: PRK05850 278137006551 AMP-binding enzyme; Region: AMP-binding; cl15778 278137006552 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 278137006553 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 278137006554 substrate binding site; other site 278137006555 tetramer interface; other site 278137006556 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 278137006557 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 278137006558 NAD binding site [chemical binding]; other site 278137006559 substrate binding site [chemical binding]; other site 278137006560 homodimer interface [polypeptide binding]; other site 278137006561 active site 278137006562 Cupin domain; Region: Cupin_2; cl09118 278137006563 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 278137006564 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 278137006565 NADP binding site [chemical binding]; other site 278137006566 active site 278137006567 putative substrate binding site [chemical binding]; other site 278137006568 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137006569 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 278137006570 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 278137006571 tetramer interface [polypeptide binding]; other site 278137006572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137006573 catalytic residue [active] 278137006574 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 278137006575 active site 278137006576 Arginase family; Region: Arginase; cl00306 278137006577 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 278137006578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137006579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137006580 S-adenosylmethionine binding site [chemical binding]; other site 278137006581 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137006582 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137006583 MULE transposase domain; Region: MULE; pfam10551 278137006584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137006585 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 278137006586 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 278137006587 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 278137006588 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137006589 active site 278137006590 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137006591 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137006592 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 278137006593 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 278137006594 active site 278137006595 putative substrate binding pocket [chemical binding]; other site 278137006596 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137006597 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 278137006598 putative hydrophobic ligand binding site [chemical binding]; other site 278137006599 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137006600 dimerization interface [polypeptide binding]; other site 278137006601 putative DNA binding site [nucleotide binding]; other site 278137006602 putative Zn2+ binding site [ion binding]; other site 278137006603 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137006604 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 278137006605 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 278137006606 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137006607 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278137006608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137006609 putative substrate translocation pore; other site 278137006610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137006611 putative substrate translocation pore; other site 278137006612 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 278137006613 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 278137006614 heme binding site [chemical binding]; other site 278137006615 ferroxidase pore; other site 278137006616 ferroxidase diiron center [ion binding]; other site 278137006617 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 278137006618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137006619 substrate binding site [chemical binding]; other site 278137006620 oxyanion hole (OAH) forming residues; other site 278137006621 trimer interface [polypeptide binding]; other site 278137006622 TIGR01666 family membrane protein; Region: YCCS 278137006623 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137006624 CoenzymeA binding site [chemical binding]; other site 278137006625 subunit interaction site [polypeptide binding]; other site 278137006626 PHB binding site; other site 278137006627 Helix-turn-helix domains; Region: HTH; cl00088 278137006628 TPR repeat; Region: TPR_11; pfam13414 278137006629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 278137006630 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 278137006631 nucleoside/Zn binding site; other site 278137006632 dimer interface [polypeptide binding]; other site 278137006633 catalytic motif [active] 278137006634 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 278137006635 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 278137006636 active site 278137006637 catalytic site [active] 278137006638 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 278137006639 Predicted esterase [General function prediction only]; Region: COG0627 278137006640 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137006641 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 278137006642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137006643 Walker A motif; other site 278137006644 ATP binding site [chemical binding]; other site 278137006645 Walker B motif; other site 278137006646 arginine finger; other site 278137006647 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 278137006648 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 278137006649 minor groove reading motif; other site 278137006650 helix-hairpin-helix signature motif; other site 278137006651 malate dehydrogenase; Provisional; Region: PRK05442 278137006652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006653 NAD(P) binding site [chemical binding]; other site 278137006654 LDH/MDH dimer interface [polypeptide binding]; other site 278137006655 substrate binding site [chemical binding]; other site 278137006656 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 278137006657 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137006658 active site 278137006659 putative phosphoketolase; Provisional; Region: PRK05261 278137006660 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 278137006661 TPP-binding site; other site 278137006662 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 278137006663 XFP C-terminal domain; Region: XFP_C; pfam09363 278137006664 CAAX protease self-immunity; Region: Abi; cl00558 278137006665 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 278137006666 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 278137006667 putative NAD(P) binding site [chemical binding]; other site 278137006668 putative substrate binding site [chemical binding]; other site 278137006669 catalytic Zn binding site [ion binding]; other site 278137006670 structural Zn binding site [ion binding]; other site 278137006671 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 278137006672 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 278137006673 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137006674 classical (c) SDRs; Region: SDR_c; cd05233 278137006675 NAD(P) binding site [chemical binding]; other site 278137006676 active site 278137006677 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137006678 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 278137006679 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 278137006680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137006681 UreD urease accessory protein; Region: UreD; cl00530 278137006682 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137006683 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 278137006684 urease subunit alpha; Reviewed; Region: ureC; PRK13206 278137006685 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 278137006686 subunit interactions [polypeptide binding]; other site 278137006687 active site 278137006688 flap region; other site 278137006689 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 278137006690 gamma-beta subunit interface [polypeptide binding]; other site 278137006691 alpha-beta subunit interface [polypeptide binding]; other site 278137006692 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 278137006693 alpha-gamma subunit interface [polypeptide binding]; other site 278137006694 beta-gamma subunit interface [polypeptide binding]; other site 278137006695 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137006696 CoenzymeA binding site [chemical binding]; other site 278137006697 subunit interaction site [polypeptide binding]; other site 278137006698 PHB binding site; other site 278137006699 Helix-turn-helix domains; Region: HTH; cl00088 278137006700 Peptidase family M48; Region: Peptidase_M48; cl12018 278137006701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006702 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 278137006703 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 278137006704 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 278137006705 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137006706 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 278137006707 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 278137006708 active site 278137006709 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 278137006710 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 278137006711 Walker A/P-loop; other site 278137006712 ATP binding site [chemical binding]; other site 278137006713 Q-loop/lid; other site 278137006714 ABC transporter signature motif; other site 278137006715 Walker B; other site 278137006716 D-loop; other site 278137006717 H-loop/switch region; other site 278137006718 TOBE domain; Region: TOBE_2; cl01440 278137006719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137006720 dimer interface [polypeptide binding]; other site 278137006721 conserved gate region; other site 278137006722 ABC-ATPase subunit interface; other site 278137006723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137006724 dimer interface [polypeptide binding]; other site 278137006725 conserved gate region; other site 278137006726 putative PBP binding loops; other site 278137006727 ABC-ATPase subunit interface; other site 278137006728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137006729 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 278137006730 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 278137006731 Domain of unknown function DUF21; Region: DUF21; pfam01595 278137006732 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 278137006733 Transporter associated domain; Region: CorC_HlyC; cl08393 278137006734 Domain of unknown function DUF21; Region: DUF21; pfam01595 278137006735 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 278137006736 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 278137006737 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 278137006738 active site 278137006739 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137006740 metal ion-dependent adhesion site (MIDAS); other site 278137006741 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 278137006742 Fatty acid desaturase; Region: FA_desaturase; pfam00487 278137006743 Di-iron ligands [ion binding]; other site 278137006744 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 278137006745 classical (c) SDRs; Region: SDR_c; cd05233 278137006746 NAD(P) binding site [chemical binding]; other site 278137006747 active site 278137006748 PE-PPE domain; Region: PE-PPE; pfam08237 278137006749 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137006750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006751 Cutinase; Region: Cutinase; pfam01083 278137006752 PE-PPE domain; Region: PE-PPE; pfam08237 278137006753 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137006754 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137006755 Cytochrome P450; Region: p450; pfam00067 278137006756 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137006757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006758 PE-PPE domain; Region: PE-PPE; pfam08237 278137006759 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137006760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137006761 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 278137006762 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137006763 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 278137006764 FMN binding site [chemical binding]; other site 278137006765 dimer interface [polypeptide binding]; other site 278137006766 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 278137006767 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278137006768 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137006769 acyltransferase PapA5; Provisional; Region: PRK09294 278137006770 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137006771 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137006772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137006773 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 278137006774 Walker A/P-loop; other site 278137006775 ATP binding site [chemical binding]; other site 278137006776 Q-loop/lid; other site 278137006777 ABC transporter signature motif; other site 278137006778 Walker B; other site 278137006779 D-loop; other site 278137006780 H-loop/switch region; other site 278137006781 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 278137006782 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137006783 active site 278137006784 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 278137006785 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137006786 peptide synthase; Provisional; Region: PRK12467 278137006787 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137006788 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 278137006789 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 278137006790 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137006791 active site 278137006792 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137006793 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 278137006794 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 278137006795 putative NADP binding site [chemical binding]; other site 278137006796 active site 278137006797 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137006798 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 278137006799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137006800 active site 278137006801 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137006802 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 278137006803 putative NADP binding site [chemical binding]; other site 278137006804 active site 278137006805 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 278137006806 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137006807 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137006808 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137006809 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 278137006810 active site 278137006811 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 278137006812 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137006813 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 278137006814 NADP binding site [chemical binding]; other site 278137006815 active site 278137006816 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137006817 acyl-CoA synthetase; Validated; Region: PRK05850 278137006818 AMP-binding enzyme; Region: AMP-binding; cl15778 278137006819 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137006820 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137006821 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 278137006822 active site 278137006823 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 278137006824 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137006825 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 278137006826 putative NADP binding site [chemical binding]; other site 278137006827 active site 278137006828 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137006829 acyl-CoA synthetase; Validated; Region: PRK05850 278137006830 AMP-binding enzyme; Region: AMP-binding; cl15778 278137006831 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 278137006832 glycine dehydrogenase; Provisional; Region: PRK05367 278137006833 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 278137006834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137006835 tetramer interface [polypeptide binding]; other site 278137006836 catalytic residue [active] 278137006837 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 278137006838 tetramer interface [polypeptide binding]; other site 278137006839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137006840 catalytic residue [active] 278137006841 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 278137006842 DNA binding residues [nucleotide binding] 278137006843 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278137006844 putative dimer interface [polypeptide binding]; other site 278137006845 Bifunctional nuclease; Region: DNase-RNase; cl00553 278137006846 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 278137006847 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278137006848 DNA binding residues [nucleotide binding] 278137006849 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 278137006850 phosphopeptide binding site; other site 278137006851 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 278137006852 lipoyl attachment site [posttranslational modification]; other site 278137006853 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 278137006854 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 278137006855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 278137006856 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 278137006857 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 278137006858 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 278137006859 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 278137006860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137006861 nucleotide binding region [chemical binding]; other site 278137006862 ATP-binding site [chemical binding]; other site 278137006863 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 278137006864 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278137006865 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 278137006866 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 278137006867 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 278137006868 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 278137006869 hypothetical protein; Validated; Region: PRK07121 278137006870 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 278137006871 substrate binding site [chemical binding]; other site 278137006872 metal binding site [ion binding]; metal-binding site 278137006873 dimer interface [polypeptide binding]; other site 278137006874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137006875 Helix-turn-helix domains; Region: HTH; cl00088 278137006876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137006877 FAD dependent oxidoreductase; Region: DAO; pfam01266 278137006878 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 278137006879 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 278137006880 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 278137006881 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137006882 substrate binding pocket [chemical binding]; other site 278137006883 catalytic triad [active] 278137006884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137006885 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 278137006886 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 278137006887 putative transposase OrfB; Reviewed; Region: PHA02517 278137006888 HTH-like domain; Region: HTH_21; pfam13276 278137006889 Integrase core domain; Region: rve; cl01316 278137006890 Integrase core domain; Region: rve_3; cl15866 278137006891 Helix-turn-helix domains; Region: HTH; cl00088 278137006892 Helix-turn-helix domains; Region: HTH; cl00088 278137006893 putative transposase OrfB; Reviewed; Region: PHA02517 278137006894 HTH-like domain; Region: HTH_21; pfam13276 278137006895 Integrase core domain; Region: rve; cl01316 278137006896 Integrase core domain; Region: rve_3; cl15866 278137006897 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 278137006898 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 278137006899 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 278137006900 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 278137006901 FMN-binding pocket [chemical binding]; other site 278137006902 flavin binding motif; other site 278137006903 phosphate binding motif [ion binding]; other site 278137006904 beta-alpha-beta structure motif; other site 278137006905 NAD binding pocket [chemical binding]; other site 278137006906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137006907 catalytic loop [active] 278137006908 iron binding site [ion binding]; other site 278137006909 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137006910 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137006911 active site 278137006912 ATP binding site [chemical binding]; other site 278137006913 substrate binding site [chemical binding]; other site 278137006914 activation loop (A-loop); other site 278137006915 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137006916 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 278137006917 nudix motif; other site 278137006918 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137006919 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137006920 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 278137006921 Transport protein; Region: actII; TIGR00833 278137006922 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137006923 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 278137006924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137006925 D-galactonate transporter; Region: 2A0114; TIGR00893 278137006926 putative substrate translocation pore; other site 278137006927 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137006928 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137006929 active site 278137006930 ethanolamine permease; Region: 2A0305; TIGR00908 278137006931 PknH-like extracellular domain; Region: PknH_C; pfam14032 278137006932 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 278137006933 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 278137006934 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 278137006935 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 278137006936 RNA binding site [nucleotide binding]; other site 278137006937 thiamine pyrophosphate protein; Provisional; Region: PRK08273 278137006938 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 278137006939 PYR/PP interface [polypeptide binding]; other site 278137006940 dimer interface [polypeptide binding]; other site 278137006941 tetramer interface [polypeptide binding]; other site 278137006942 TPP binding site [chemical binding]; other site 278137006943 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 278137006944 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 278137006945 TPP-binding site [chemical binding]; other site 278137006946 hydroperoxidase II; Provisional; Region: katE; PRK11249 278137006947 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 278137006948 heme binding pocket [chemical binding]; other site 278137006949 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 278137006950 domain interactions; other site 278137006951 PAS fold; Region: PAS_3; pfam08447 278137006952 ANTAR domain; Region: ANTAR; cl04297 278137006953 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 278137006954 PhoU domain; Region: PhoU; pfam01895 278137006955 PhoU domain; Region: PhoU; pfam01895 278137006956 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137006957 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 278137006958 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 278137006959 heme binding site [chemical binding]; other site 278137006960 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 278137006961 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 278137006962 metal binding site 2 [ion binding]; metal-binding site 278137006963 putative DNA binding helix; other site 278137006964 metal binding site 1 [ion binding]; metal-binding site 278137006965 dimer interface [polypeptide binding]; other site 278137006966 structural Zn2+ binding site [ion binding]; other site 278137006967 Acyltransferase family; Region: Acyl_transf_3; pfam01757 278137006968 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 278137006969 Sulfatase; Region: Sulfatase; cl10460 278137006970 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 278137006971 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137006972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137006973 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 278137006974 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 278137006975 FAD binding site [chemical binding]; other site 278137006976 Cobalt transport protein; Region: CbiQ; cl00463 278137006977 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 278137006978 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 278137006979 Walker A/P-loop; other site 278137006980 ATP binding site [chemical binding]; other site 278137006981 Q-loop/lid; other site 278137006982 ABC transporter signature motif; other site 278137006983 Walker B; other site 278137006984 D-loop; other site 278137006985 H-loop/switch region; other site 278137006986 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 278137006987 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137006988 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137006989 short chain dehydrogenase; Provisional; Region: PRK05866 278137006990 classical (c) SDRs; Region: SDR_c; cd05233 278137006991 NAD(P) binding site [chemical binding]; other site 278137006992 active site 278137006993 EamA-like transporter family; Region: EamA; cl01037 278137006994 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 278137006995 Low molecular weight phosphatase family; Region: LMWPc; cl00105 278137006996 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 278137006997 active site 278137006998 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 278137006999 Membrane transport protein; Region: Mem_trans; cl09117 278137007000 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 278137007001 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137007002 putative metal binding site [ion binding]; other site 278137007003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137007004 dimerization interface [polypeptide binding]; other site 278137007005 putative DNA binding site [nucleotide binding]; other site 278137007006 putative Zn2+ binding site [ion binding]; other site 278137007007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278137007008 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137007009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137007010 Helix-turn-helix domains; Region: HTH; cl00088 278137007011 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137007012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 278137007013 Transposase; Region: DDE_Tnp_ISL3; pfam01610 278137007014 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137007015 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137007016 active site 278137007017 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137007018 metal binding site [ion binding]; metal-binding site 278137007019 active site 278137007020 I-site; other site 278137007021 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137007022 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137007023 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 278137007024 NAD(P) binding site [chemical binding]; other site 278137007025 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 278137007026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007027 tropinone reductase; Provisional; Region: PRK09242 278137007028 NAD(P) binding site [chemical binding]; other site 278137007029 active site 278137007030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137007031 classical (c) SDRs; Region: SDR_c; cd05233 278137007032 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 278137007033 NAD(P) binding site [chemical binding]; other site 278137007034 active site 278137007035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 278137007036 Helix-turn-helix domains; Region: HTH; cl00088 278137007037 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 278137007038 Predicted transcriptional regulator [Transcription]; Region: COG2345 278137007039 Helix-turn-helix domains; Region: HTH; cl00088 278137007040 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137007041 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 278137007042 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 278137007043 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 278137007044 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 278137007045 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 278137007046 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 278137007047 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 278137007048 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 278137007049 GTP-binding protein Der; Reviewed; Region: PRK03003 278137007050 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 278137007051 G1 box; other site 278137007052 GTP/Mg2+ binding site [chemical binding]; other site 278137007053 Switch I region; other site 278137007054 G2 box; other site 278137007055 Switch II region; other site 278137007056 G3 box; other site 278137007057 G4 box; other site 278137007058 G5 box; other site 278137007059 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 278137007060 G1 box; other site 278137007061 GTP/Mg2+ binding site [chemical binding]; other site 278137007062 Switch I region; other site 278137007063 G2 box; other site 278137007064 G3 box; other site 278137007065 Switch II region; other site 278137007066 G4 box; other site 278137007067 G5 box; other site 278137007068 cytidylate kinase; Provisional; Region: cmk; PRK00023 278137007069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137007070 active site 278137007071 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 278137007072 CMP-binding site; other site 278137007073 The sites determining sugar specificity; other site 278137007074 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 278137007075 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278137007076 RNA binding surface [nucleotide binding]; other site 278137007077 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 278137007078 active site 278137007079 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 278137007080 ScpA/B protein; Region: ScpA_ScpB; cl00598 278137007081 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 278137007082 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137007083 P-loop; other site 278137007084 Magnesium ion binding site [ion binding]; other site 278137007085 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137007086 Magnesium ion binding site [ion binding]; other site 278137007087 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 278137007088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137007089 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 278137007090 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 278137007091 active site 278137007092 Int/Topo IB signature motif; other site 278137007093 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 278137007094 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 278137007095 dimer interface [polypeptide binding]; other site 278137007096 ADP-ribose binding site [chemical binding]; other site 278137007097 active site 278137007098 nudix motif; other site 278137007099 metal binding site [ion binding]; metal-binding site 278137007100 CTP synthetase; Validated; Region: pyrG; PRK05380 278137007101 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 278137007102 Catalytic site [active] 278137007103 active site 278137007104 UTP binding site [chemical binding]; other site 278137007105 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 278137007106 active site 278137007107 putative oxyanion hole; other site 278137007108 catalytic triad [active] 278137007109 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 278137007110 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 278137007111 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 278137007112 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 278137007113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 278137007114 active site 278137007115 metal binding site [ion binding]; metal-binding site 278137007116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137007117 Helix-turn-helix domains; Region: HTH; cl00088 278137007118 DNA repair protein RecN; Region: recN; TIGR00634 278137007119 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 278137007120 Walker A/P-loop; other site 278137007121 ATP binding site [chemical binding]; other site 278137007122 Q-loop/lid; other site 278137007123 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 278137007124 ABC transporter signature motif; other site 278137007125 Walker B; other site 278137007126 D-loop; other site 278137007127 H-loop/switch region; other site 278137007128 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 278137007129 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 278137007130 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 278137007131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278137007132 RNA binding surface [nucleotide binding]; other site 278137007133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137007134 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 278137007135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137007136 active site 278137007137 motif I; other site 278137007138 motif II; other site 278137007139 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137007140 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 278137007141 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 278137007142 active site 278137007143 HIGH motif; other site 278137007144 dimer interface [polypeptide binding]; other site 278137007145 KMSKS motif; other site 278137007146 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 278137007147 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 278137007148 Trm112p-like protein; Region: Trm112p; cl01066 278137007149 acyl-CoA synthetase; Validated; Region: PRK07868 278137007150 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 278137007151 AMP-binding enzyme; Region: AMP-binding; cl15778 278137007152 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278137007153 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278137007154 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278137007155 chromosome segregation protein; Provisional; Region: PRK03918 278137007156 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 278137007157 argininosuccinate lyase; Provisional; Region: PRK00855 278137007158 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 278137007159 active sites [active] 278137007160 tetramer interface [polypeptide binding]; other site 278137007161 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 278137007162 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 278137007163 ANP binding site [chemical binding]; other site 278137007164 Substrate Binding Site II [chemical binding]; other site 278137007165 Substrate Binding Site I [chemical binding]; other site 278137007166 arginine repressor; Region: argR_whole; TIGR01529 278137007167 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 278137007168 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 278137007169 ornithine carbamoyltransferase; Provisional; Region: PRK00779 278137007170 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 278137007171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007172 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 278137007173 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137007174 inhibitor-cofactor binding pocket; inhibition site 278137007175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137007176 catalytic residue [active] 278137007177 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 278137007178 feedback inhibition sensing region; other site 278137007179 homohexameric interface [polypeptide binding]; other site 278137007180 nucleotide binding site [chemical binding]; other site 278137007181 N-acetyl-L-glutamate binding site [chemical binding]; other site 278137007182 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 278137007183 heterotetramer interface [polypeptide binding]; other site 278137007184 active site pocket [active] 278137007185 cleavage site 278137007186 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 278137007187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007188 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 278137007189 hydroxyglutarate oxidase; Provisional; Region: PRK11728 278137007190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007191 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 278137007192 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 278137007193 putative tRNA-binding site [nucleotide binding]; other site 278137007194 B3/4 domain; Region: B3_4; cl11458 278137007195 tRNA synthetase B5 domain; Region: B5; cl08394 278137007196 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 278137007197 dimer interface [polypeptide binding]; other site 278137007198 motif 1; other site 278137007199 motif 3; other site 278137007200 motif 2; other site 278137007201 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 278137007202 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 278137007203 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 278137007204 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 278137007205 dimer interface [polypeptide binding]; other site 278137007206 motif 1; other site 278137007207 active site 278137007208 motif 2; other site 278137007209 motif 3; other site 278137007210 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 278137007211 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 278137007212 cyclase homology domain; Region: CHD; cd07302 278137007213 nucleotidyl binding site; other site 278137007214 metal binding site [ion binding]; metal-binding site 278137007215 dimer interface [polypeptide binding]; other site 278137007216 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137007217 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137007218 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137007219 active site 278137007220 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278137007221 classical (c) SDRs; Region: SDR_c; cd05233 278137007222 NAD(P) binding site [chemical binding]; other site 278137007223 active site 278137007224 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 278137007225 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 278137007226 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 278137007227 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 278137007228 23S rRNA binding site [nucleotide binding]; other site 278137007229 L21 binding site [polypeptide binding]; other site 278137007230 L13 binding site [polypeptide binding]; other site 278137007231 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 278137007232 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 278137007233 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 278137007234 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 278137007235 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 278137007236 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 278137007237 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 278137007238 dimer interface [polypeptide binding]; other site 278137007239 putative anticodon binding site; other site 278137007240 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 278137007241 motif 1; other site 278137007242 dimer interface [polypeptide binding]; other site 278137007243 active site 278137007244 motif 2; other site 278137007245 motif 3; other site 278137007246 Predicted esterase [General function prediction only]; Region: COG0627 278137007247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137007248 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 278137007249 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 278137007250 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 278137007251 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 278137007252 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 278137007253 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 278137007254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137007255 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137007256 catalytic residue [active] 278137007257 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137007258 Ligand Binding Site [chemical binding]; other site 278137007259 Cutinase; Region: Cutinase; pfam01083 278137007260 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 278137007261 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 278137007262 excinuclease ABC subunit B; Provisional; Region: PRK05298 278137007263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137007264 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137007265 nucleotide binding region [chemical binding]; other site 278137007266 ATP-binding site [chemical binding]; other site 278137007267 Ultra-violet resistance protein B; Region: UvrB; pfam12344 278137007268 UvrB/uvrC motif; Region: UVR; pfam02151 278137007269 Protein of unknown function (DUF402); Region: DUF402; cl00979 278137007270 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 278137007271 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 278137007272 CoA-binding site [chemical binding]; other site 278137007273 ATP-binding [chemical binding]; other site 278137007274 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 278137007275 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 278137007276 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 278137007277 RNA binding site [nucleotide binding]; other site 278137007278 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 278137007279 RNA binding site [nucleotide binding]; other site 278137007280 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 278137007281 RNA binding site [nucleotide binding]; other site 278137007282 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 278137007283 RNA binding site [nucleotide binding]; other site 278137007284 Protease prsW family; Region: PrsW-protease; cl15823 278137007285 DNA polymerase I; Provisional; Region: PRK05755 278137007286 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 278137007287 active site 278137007288 metal binding site 1 [ion binding]; metal-binding site 278137007289 putative 5' ssDNA interaction site; other site 278137007290 metal binding site 3; metal-binding site 278137007291 metal binding site 2 [ion binding]; metal-binding site 278137007292 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 278137007293 putative DNA binding site [nucleotide binding]; other site 278137007294 putative metal binding site [ion binding]; other site 278137007295 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 278137007296 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 278137007297 active site 278137007298 DNA binding site [nucleotide binding] 278137007299 catalytic site [active] 278137007300 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 278137007301 Helix-turn-helix domains; Region: HTH; cl00088 278137007302 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 278137007303 putative dimerization interface [polypeptide binding]; other site 278137007304 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137007305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137007306 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 278137007307 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 278137007308 DUF35 OB-fold domain; Region: DUF35; pfam01796 278137007309 lipid-transfer protein; Provisional; Region: PRK06059 278137007310 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137007311 active site 278137007312 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 278137007313 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 278137007314 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 278137007315 Walker A/P-loop; other site 278137007316 ATP binding site [chemical binding]; other site 278137007317 Q-loop/lid; other site 278137007318 ABC transporter signature motif; other site 278137007319 Walker B; other site 278137007320 D-loop; other site 278137007321 H-loop/switch region; other site 278137007322 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 278137007323 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 278137007324 Walker A/P-loop; other site 278137007325 ATP binding site [chemical binding]; other site 278137007326 Q-loop/lid; other site 278137007327 ABC transporter signature motif; other site 278137007328 Walker B; other site 278137007329 D-loop; other site 278137007330 H-loop/switch region; other site 278137007331 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 278137007332 TM-ABC transporter signature motif; other site 278137007333 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 278137007334 TM-ABC transporter signature motif; other site 278137007335 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 278137007336 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 278137007337 dimerization interface [polypeptide binding]; other site 278137007338 ligand binding site [chemical binding]; other site 278137007339 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 278137007340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137007341 active site 278137007342 phosphorylation site [posttranslational modification] 278137007343 intermolecular recognition site; other site 278137007344 dimerization interface [polypeptide binding]; other site 278137007345 ANTAR domain; Region: ANTAR; cl04297 278137007346 Heme NO binding associated; Region: HNOBA; pfam07701 278137007347 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 278137007348 cyclase homology domain; Region: CHD; cd07302 278137007349 nucleotidyl binding site; other site 278137007350 metal binding site [ion binding]; metal-binding site 278137007351 dimer interface [polypeptide binding]; other site 278137007352 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 278137007353 Ferritin-like domain; Region: Ferritin; pfam00210 278137007354 dimerization interface [polypeptide binding]; other site 278137007355 DPS ferroxidase diiron center [ion binding]; other site 278137007356 ion pore; other site 278137007357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 278137007358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137007359 active site 278137007360 phosphorylation site [posttranslational modification] 278137007361 intermolecular recognition site; other site 278137007362 dimerization interface [polypeptide binding]; other site 278137007363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137007364 DNA binding residues [nucleotide binding] 278137007365 dimerization interface [polypeptide binding]; other site 278137007366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 278137007367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137007368 ATP binding site [chemical binding]; other site 278137007369 Mg2+ binding site [ion binding]; other site 278137007370 G-X-G motif; other site 278137007371 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278137007372 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 278137007373 Walker A/P-loop; other site 278137007374 ATP binding site [chemical binding]; other site 278137007375 Q-loop/lid; other site 278137007376 ABC transporter signature motif; other site 278137007377 Walker B; other site 278137007378 D-loop; other site 278137007379 H-loop/switch region; other site 278137007380 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278137007381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137007382 dimer interface [polypeptide binding]; other site 278137007383 conserved gate region; other site 278137007384 putative PBP binding loops; other site 278137007385 ABC-ATPase subunit interface; other site 278137007386 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278137007387 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137007388 substrate binding pocket [chemical binding]; other site 278137007389 membrane-bound complex binding site; other site 278137007390 hinge residues; other site 278137007391 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 278137007392 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 278137007393 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 278137007394 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 278137007395 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 278137007396 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 278137007397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137007398 Walker A/P-loop; other site 278137007399 ATP binding site [chemical binding]; other site 278137007400 Q-loop/lid; other site 278137007401 ABC transporter signature motif; other site 278137007402 Walker B; other site 278137007403 D-loop; other site 278137007404 H-loop/switch region; other site 278137007405 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 278137007406 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137007407 Walker A/P-loop; other site 278137007408 ATP binding site [chemical binding]; other site 278137007409 ABC transporter signature motif; other site 278137007410 Walker B; other site 278137007411 D-loop; other site 278137007412 H-loop/switch region; other site 278137007413 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 278137007414 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 278137007415 active site 278137007416 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 278137007417 catalytic triad [active] 278137007418 dimer interface [polypeptide binding]; other site 278137007419 pyruvate kinase; Provisional; Region: PRK06247 278137007420 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137007421 domain interfaces; other site 278137007422 active site 278137007423 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 278137007424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007425 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 278137007426 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 278137007427 active site 278137007428 dimer interface [polypeptide binding]; other site 278137007429 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 278137007430 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 278137007431 active site 278137007432 FMN binding site [chemical binding]; other site 278137007433 substrate binding site [chemical binding]; other site 278137007434 3Fe-4S cluster binding site [ion binding]; other site 278137007435 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 278137007436 domain interface; other site 278137007437 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 278137007438 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137007439 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137007440 active site 278137007441 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 278137007442 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 278137007443 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 278137007444 substrate binding site [chemical binding]; other site 278137007445 active site 278137007446 catalytic residues [active] 278137007447 heterodimer interface [polypeptide binding]; other site 278137007448 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 278137007449 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 278137007450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137007451 catalytic residue [active] 278137007452 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 278137007453 active site 278137007454 ribulose/triose binding site [chemical binding]; other site 278137007455 phosphate binding site [ion binding]; other site 278137007456 substrate (anthranilate) binding pocket [chemical binding]; other site 278137007457 product (indole) binding pocket [chemical binding]; other site 278137007458 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 278137007459 anthranilate synthase component I; Provisional; Region: PRK13571 278137007460 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 278137007461 chorismate binding enzyme; Region: Chorismate_bind; cl10555 278137007462 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 278137007463 catalytic triad [active] 278137007464 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 278137007465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137007466 Walker A/P-loop; other site 278137007467 ATP binding site [chemical binding]; other site 278137007468 Q-loop/lid; other site 278137007469 ABC transporter signature motif; other site 278137007470 Walker B; other site 278137007471 D-loop; other site 278137007472 H-loop/switch region; other site 278137007473 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 278137007474 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 278137007475 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 278137007476 substrate binding site [chemical binding]; other site 278137007477 glutamase interaction surface [polypeptide binding]; other site 278137007478 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 278137007479 active site 278137007480 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 278137007481 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 278137007482 catalytic residues [active] 278137007483 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 278137007484 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 278137007485 putative active site [active] 278137007486 oxyanion strand; other site 278137007487 catalytic triad [active] 278137007488 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 278137007489 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 278137007490 putative active site pocket [active] 278137007491 4-fold oligomerization interface [polypeptide binding]; other site 278137007492 metal binding residues [ion binding]; metal-binding site 278137007493 3-fold/trimer interface [polypeptide binding]; other site 278137007494 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 278137007495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278137007496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137007497 homodimer interface [polypeptide binding]; other site 278137007498 catalytic residue [active] 278137007499 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 278137007500 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 278137007501 NAD binding site [chemical binding]; other site 278137007502 dimerization interface [polypeptide binding]; other site 278137007503 product binding site; other site 278137007504 substrate binding site [chemical binding]; other site 278137007505 zinc binding site [ion binding]; other site 278137007506 catalytic residues [active] 278137007507 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137007508 LysE type translocator; Region: LysE; cl00565 278137007509 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 278137007510 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 278137007511 dimerization interface [polypeptide binding]; other site 278137007512 active site 278137007513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007514 L-aspartate oxidase; Region: nadB; TIGR00551 278137007515 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 278137007516 Quinolinate synthetase A protein; Region: NadA; cl00420 278137007517 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 278137007518 nudix motif; other site 278137007519 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 278137007520 Secretory lipase; Region: LIP; pfam03583 278137007521 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 278137007522 biotin synthase; Validated; Region: PRK06256 278137007523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137007524 FeS/SAM binding site; other site 278137007525 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 278137007526 Helix-turn-helix domains; Region: HTH; cl00088 278137007527 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 278137007528 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 278137007529 AAA domain; Region: AAA_26; pfam13500 278137007530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137007531 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137007532 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 278137007533 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137007534 catalytic residue [active] 278137007535 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 278137007536 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137007537 inhibitor-cofactor binding pocket; inhibition site 278137007538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137007539 catalytic residue [active] 278137007540 OpgC protein; Region: OpgC_C; cl00792 278137007541 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 278137007542 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 278137007543 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 278137007544 active site 278137007545 catalytic site [active] 278137007546 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 278137007547 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 278137007548 active site 278137007549 catalytic site [active] 278137007550 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 278137007551 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 278137007552 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 278137007553 catalytic site [active] 278137007554 active site 278137007555 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 278137007556 threonine dehydratase; Validated; Region: PRK08639 278137007557 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 278137007558 tetramer interface [polypeptide binding]; other site 278137007559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137007560 catalytic residue [active] 278137007561 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 278137007562 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 278137007563 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 278137007564 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 278137007565 generic binding surface II; other site 278137007566 generic binding surface I; other site 278137007567 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 278137007568 Helix-turn-helix domains; Region: HTH; cl00088 278137007569 Predicted permeases [General function prediction only]; Region: RarD; COG2962 278137007570 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 278137007571 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 278137007572 active site 278137007573 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 278137007574 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 278137007575 active site 278137007576 homotetramer interface [polypeptide binding]; other site 278137007577 homodimer interface [polypeptide binding]; other site 278137007578 DNA polymerase IV; Provisional; Region: PRK03348 278137007579 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 278137007580 active site 278137007581 DNA binding site [nucleotide binding] 278137007582 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278137007583 RNA binding surface [nucleotide binding]; other site 278137007584 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 278137007585 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 278137007586 HIGH motif; other site 278137007587 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 278137007588 active site 278137007589 KMSKS motif; other site 278137007590 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 278137007591 tRNA binding surface [nucleotide binding]; other site 278137007592 anticodon binding site; other site 278137007593 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137007594 membrane ATPase/protein kinase; Provisional; Region: PRK09435 278137007595 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 278137007596 Walker A; other site 278137007597 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137007598 G4 box; other site 278137007599 G5 box; other site 278137007600 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 278137007601 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 278137007602 active site 278137007603 substrate binding site [chemical binding]; other site 278137007604 coenzyme B12 binding site [chemical binding]; other site 278137007605 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 278137007606 B12 binding site [chemical binding]; other site 278137007607 cobalt ligand [ion binding]; other site 278137007608 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 278137007609 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 278137007610 heterodimer interface [polypeptide binding]; other site 278137007611 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 278137007612 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278137007613 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137007614 MULE transposase domain; Region: MULE; pfam10551 278137007615 DoxX; Region: DoxX; cl00976 278137007616 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 278137007617 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 278137007618 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 278137007619 ferrochelatase; Reviewed; Region: hemH; PRK00035 278137007620 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 278137007621 C-terminal domain interface [polypeptide binding]; other site 278137007622 active site 278137007623 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 278137007624 active site 278137007625 N-terminal domain interface [polypeptide binding]; other site 278137007626 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 278137007627 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 278137007628 NAD binding site [chemical binding]; other site 278137007629 homotetramer interface [polypeptide binding]; other site 278137007630 homodimer interface [polypeptide binding]; other site 278137007631 substrate binding site [chemical binding]; other site 278137007632 active site 278137007633 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 278137007634 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 278137007635 NAD(P) binding site [chemical binding]; other site 278137007636 homotetramer interface [polypeptide binding]; other site 278137007637 homodimer interface [polypeptide binding]; other site 278137007638 active site 278137007639 hypothetical protein; Provisional; Region: PRK13685 278137007640 Aerotolerance regulator N-terminal; Region: BatA; cl06567 278137007641 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137007642 metal ion-dependent adhesion site (MIDAS); other site 278137007643 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 278137007644 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137007645 MoxR-like ATPases [General function prediction only]; Region: COG0714 278137007646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137007647 Walker A motif; other site 278137007648 ATP binding site [chemical binding]; other site 278137007649 Walker B motif; other site 278137007650 arginine finger; other site 278137007651 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 278137007652 NlpC/P60 family; Region: NLPC_P60; cl11438 278137007653 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 278137007654 NlpC/P60 family; Region: NLPC_P60; cl11438 278137007655 aconitate hydratase; Validated; Region: PRK09277 278137007656 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 278137007657 substrate binding site [chemical binding]; other site 278137007658 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 278137007659 ligand binding site [chemical binding]; other site 278137007660 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 278137007661 substrate binding site [chemical binding]; other site 278137007662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137007663 Helix-turn-helix domains; Region: HTH; cl00088 278137007664 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278137007665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137007666 Walker A/P-loop; other site 278137007667 ATP binding site [chemical binding]; other site 278137007668 Q-loop/lid; other site 278137007669 ABC transporter signature motif; other site 278137007670 Walker B; other site 278137007671 D-loop; other site 278137007672 H-loop/switch region; other site 278137007673 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278137007674 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278137007675 catalytic residues [active] 278137007676 Domain of unknown function DUF59; Region: DUF59; cl00941 278137007677 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 278137007678 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 278137007679 trimerization site [polypeptide binding]; other site 278137007680 active site 278137007681 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 278137007682 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 278137007683 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137007684 catalytic residue [active] 278137007685 FeS assembly ATPase SufC; Region: sufC; TIGR01978 278137007686 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 278137007687 Walker A/P-loop; other site 278137007688 ATP binding site [chemical binding]; other site 278137007689 Q-loop/lid; other site 278137007690 ABC transporter signature motif; other site 278137007691 Walker B; other site 278137007692 D-loop; other site 278137007693 H-loop/switch region; other site 278137007694 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 278137007695 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 278137007696 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 278137007697 FeS assembly protein SufB; Region: sufB; TIGR01980 278137007698 Predicted transcriptional regulator [Transcription]; Region: COG2345 278137007699 Helix-turn-helix domains; Region: HTH; cl00088 278137007700 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 278137007701 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 278137007702 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 278137007703 Walker A/P-loop; other site 278137007704 ATP binding site [chemical binding]; other site 278137007705 Q-loop/lid; other site 278137007706 ABC transporter signature motif; other site 278137007707 Walker B; other site 278137007708 D-loop; other site 278137007709 H-loop/switch region; other site 278137007710 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137007711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137007712 Helix-turn-helix domains; Region: HTH; cl00088 278137007713 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 278137007714 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 278137007715 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137007716 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 278137007717 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 278137007718 NADP binding site [chemical binding]; other site 278137007719 dimer interface [polypeptide binding]; other site 278137007720 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 278137007721 Uncharacterized conserved protein [Function unknown]; Region: COG5361 278137007722 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 278137007723 UbiA prenyltransferase family; Region: UbiA; cl00337 278137007724 transketolase; Reviewed; Region: PRK05899 278137007725 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 278137007726 TPP-binding site [chemical binding]; other site 278137007727 dimer interface [polypeptide binding]; other site 278137007728 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 278137007729 PYR/PP interface [polypeptide binding]; other site 278137007730 dimer interface [polypeptide binding]; other site 278137007731 TPP binding site [chemical binding]; other site 278137007732 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 278137007733 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 278137007734 putative active site [active] 278137007735 transaldolase; Provisional; Region: PRK03903 278137007736 catalytic residue [active] 278137007737 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 278137007738 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 278137007739 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 278137007740 opcA protein; Region: OpcA; TIGR00534 278137007741 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 278137007742 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 278137007743 putative active site [active] 278137007744 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137007745 putative transposase OrfB; Reviewed; Region: PHA02517 278137007746 HTH-like domain; Region: HTH_21; pfam13276 278137007747 Integrase core domain; Region: rve; cl01316 278137007748 Integrase core domain; Region: rve_3; cl15866 278137007749 Helix-turn-helix domains; Region: HTH; cl00088 278137007750 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 278137007751 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 278137007752 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 278137007753 Cysteine-rich domain; Region: CCG; pfam02754 278137007754 Cysteine-rich domain; Region: CCG; pfam02754 278137007755 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 278137007756 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 278137007757 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 278137007758 substrate binding site [chemical binding]; other site 278137007759 dimer interface [polypeptide binding]; other site 278137007760 catalytic triad [active] 278137007761 Phosphoglycerate kinase; Region: PGK; pfam00162 278137007762 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 278137007763 substrate binding site [chemical binding]; other site 278137007764 hinge regions; other site 278137007765 ADP binding site [chemical binding]; other site 278137007766 catalytic site [active] 278137007767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007768 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 278137007769 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 278137007770 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278137007771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137007772 substrate binding pocket [chemical binding]; other site 278137007773 membrane-bound complex binding site; other site 278137007774 hinge residues; other site 278137007775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 278137007776 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 278137007777 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 278137007778 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 278137007779 phosphate binding site [ion binding]; other site 278137007780 putative substrate binding pocket [chemical binding]; other site 278137007781 dimer interface [polypeptide binding]; other site 278137007782 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 278137007783 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 278137007784 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 278137007785 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 278137007786 GIY-YIG motif/motif A; other site 278137007787 active site 278137007788 catalytic site [active] 278137007789 putative DNA binding site [nucleotide binding]; other site 278137007790 metal binding site [ion binding]; metal-binding site 278137007791 UvrB/uvrC motif; Region: UVR; pfam02151 278137007792 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 278137007793 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 278137007794 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 278137007795 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 278137007796 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 278137007797 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 278137007798 homopentamer interface [polypeptide binding]; other site 278137007799 active site 278137007800 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 278137007801 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 278137007802 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 278137007803 dimerization interface [polypeptide binding]; other site 278137007804 active site 278137007805 PE-PPE domain; Region: PE-PPE; pfam08237 278137007806 Lumazine binding domain; Region: Lum_binding; pfam00677 278137007807 Lumazine binding domain; Region: Lum_binding; pfam00677 278137007808 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 278137007809 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137007810 trehalose synthase; Region: treS_nterm; TIGR02456 278137007811 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 278137007812 active site 278137007813 catalytic site [active] 278137007814 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 278137007815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137007816 putative substrate translocation pore; other site 278137007817 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 278137007818 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 278137007819 active site 278137007820 Zn binding site [ion binding]; other site 278137007821 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 278137007822 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 278137007823 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 278137007824 substrate binding site [chemical binding]; other site 278137007825 hexamer interface [polypeptide binding]; other site 278137007826 metal binding site [ion binding]; metal-binding site 278137007827 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 278137007828 putative RNA binding site [nucleotide binding]; other site 278137007829 16S rRNA methyltransferase B; Provisional; Region: PRK14902 278137007830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137007831 S-adenosylmethionine binding site [chemical binding]; other site 278137007832 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 278137007833 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 278137007834 putative active site [active] 278137007835 substrate binding site [chemical binding]; other site 278137007836 putative cosubstrate binding site; other site 278137007837 catalytic site [active] 278137007838 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 278137007839 substrate binding site [chemical binding]; other site 278137007840 LemA family; Region: LemA; cl00742 278137007841 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 278137007842 primosome assembly protein PriA; Provisional; Region: PRK14873 278137007843 YhhN-like protein; Region: YhhN; cl01505 278137007844 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137007845 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137007846 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137007847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007848 S-adenosylmethionine synthetase; Validated; Region: PRK05250 278137007849 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 278137007850 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 278137007851 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 278137007852 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 278137007853 Flavoprotein; Region: Flavoprotein; cl08021 278137007854 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 278137007855 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 278137007856 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 278137007857 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 278137007858 catalytic site [active] 278137007859 G-X2-G-X-G-K; other site 278137007860 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 278137007861 active site 278137007862 dimer interface [polypeptide binding]; other site 278137007863 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 278137007864 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278137007865 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137007866 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 278137007867 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278137007868 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137007869 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 278137007870 IMP binding site; other site 278137007871 dimer interface [polypeptide binding]; other site 278137007872 interdomain contacts; other site 278137007873 partial ornithine binding site; other site 278137007874 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 278137007875 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 278137007876 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 278137007877 catalytic site [active] 278137007878 subunit interface [polypeptide binding]; other site 278137007879 dihydroorotase; Validated; Region: pyrC; PRK09357 278137007880 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137007881 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 278137007882 active site 278137007883 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 278137007884 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 278137007885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137007886 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137007887 active site 278137007888 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 278137007889 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137007890 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137007891 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 278137007892 putative RNA binding site [nucleotide binding]; other site 278137007893 elongation factor P; Validated; Region: PRK00529 278137007894 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 278137007895 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 278137007896 RNA binding site [nucleotide binding]; other site 278137007897 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 278137007898 RNA binding site [nucleotide binding]; other site 278137007899 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 278137007900 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 278137007901 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 278137007902 active site 278137007903 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 278137007904 active site 278137007905 dimer interface [polypeptide binding]; other site 278137007906 metal binding site [ion binding]; metal-binding site 278137007907 shikimate kinase; Reviewed; Region: aroK; PRK00131 278137007908 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 278137007909 ADP binding site [chemical binding]; other site 278137007910 magnesium binding site [ion binding]; other site 278137007911 putative shikimate binding site; other site 278137007912 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 278137007913 Tetramer interface [polypeptide binding]; other site 278137007914 active site 278137007915 FMN-binding site [chemical binding]; other site 278137007916 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 278137007917 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 278137007918 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 278137007919 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 278137007920 NAD(P) binding site [chemical binding]; other site 278137007921 shikimate binding site; other site 278137007922 YceG-like family; Region: YceG; pfam02618 278137007923 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 278137007924 dimerization interface [polypeptide binding]; other site 278137007925 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 278137007926 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 278137007927 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 278137007928 motif 1; other site 278137007929 active site 278137007930 motif 2; other site 278137007931 motif 3; other site 278137007932 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 278137007933 DHHA1 domain; Region: DHHA1; pfam02272 278137007934 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 278137007935 recombination factor protein RarA; Reviewed; Region: PRK13342 278137007936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137007937 Walker A motif; other site 278137007938 ATP binding site [chemical binding]; other site 278137007939 Walker B motif; other site 278137007940 arginine finger; other site 278137007941 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 278137007942 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 278137007943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 278137007944 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 278137007945 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 278137007946 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 278137007947 Uncharacterized conserved protein [Function unknown]; Region: COG2308 278137007948 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 278137007949 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 278137007950 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 278137007951 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 278137007952 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 278137007953 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 278137007954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 278137007955 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 278137007956 Helix-turn-helix domains; Region: HTH; cl00088 278137007957 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137007958 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 278137007959 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 278137007960 N- and C-terminal domain interface [polypeptide binding]; other site 278137007961 putative active site [active] 278137007962 catalytic site [active] 278137007963 metal binding site [ion binding]; metal-binding site 278137007964 putative xylulose binding site [chemical binding]; other site 278137007965 putative ATP binding site [chemical binding]; other site 278137007966 putative homodimer interface [polypeptide binding]; other site 278137007967 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 278137007968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137007969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137007970 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 278137007971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137007972 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 278137007973 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 278137007974 Walker A/P-loop; other site 278137007975 ATP binding site [chemical binding]; other site 278137007976 Q-loop/lid; other site 278137007977 ABC transporter signature motif; other site 278137007978 Walker B; other site 278137007979 D-loop; other site 278137007980 H-loop/switch region; other site 278137007981 TOBE domain; Region: TOBE_2; cl01440 278137007982 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137007983 classical (c) SDRs; Region: SDR_c; cd05233 278137007984 NAD(P) binding site [chemical binding]; other site 278137007985 active site 278137007986 BtpA family; Region: BtpA; cl00440 278137007987 Helix-turn-helix domains; Region: HTH; cl00088 278137007988 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 278137007989 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137007990 dimer interface [polypeptide binding]; other site 278137007991 active site 278137007992 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137007993 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 278137007994 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 278137007995 dimer interface [polypeptide binding]; other site 278137007996 anticodon binding site; other site 278137007997 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 278137007998 homodimer interface [polypeptide binding]; other site 278137007999 motif 1; other site 278137008000 active site 278137008001 motif 2; other site 278137008002 GAD domain; Region: GAD; pfam02938 278137008003 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 278137008004 active site 278137008005 motif 3; other site 278137008006 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 278137008007 putative hydrophobic ligand binding site [chemical binding]; other site 278137008008 protein interface [polypeptide binding]; other site 278137008009 gate; other site 278137008010 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 278137008011 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137008012 substrate binding pocket [chemical binding]; other site 278137008013 catalytic triad [active] 278137008014 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 278137008015 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 278137008016 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 278137008017 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 278137008018 active site 278137008019 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 278137008020 catalytic triad [active] 278137008021 dimer interface [polypeptide binding]; other site 278137008022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137008023 Helix-turn-helix domains; Region: HTH; cl00088 278137008024 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137008025 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137008026 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137008027 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 278137008028 active site 278137008029 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137008030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137008031 active site 278137008032 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 278137008033 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 278137008034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137008035 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 278137008036 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 278137008037 putative ligand binding site [chemical binding]; other site 278137008038 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 278137008039 TM-ABC transporter signature motif; other site 278137008040 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 278137008041 TM-ABC transporter signature motif; other site 278137008042 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 278137008043 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 278137008044 Walker A/P-loop; other site 278137008045 ATP binding site [chemical binding]; other site 278137008046 Q-loop/lid; other site 278137008047 ABC transporter signature motif; other site 278137008048 Walker B; other site 278137008049 D-loop; other site 278137008050 H-loop/switch region; other site 278137008051 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 278137008052 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 278137008053 Walker A/P-loop; other site 278137008054 ATP binding site [chemical binding]; other site 278137008055 Q-loop/lid; other site 278137008056 ABC transporter signature motif; other site 278137008057 Walker B; other site 278137008058 D-loop; other site 278137008059 H-loop/switch region; other site 278137008060 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 278137008061 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 278137008062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137008063 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 278137008064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137008065 DNA binding residues [nucleotide binding] 278137008066 Protein of unknown function (DUF461); Region: DUF461; cl01071 278137008067 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 278137008068 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 278137008069 dimer interface [polypeptide binding]; other site 278137008070 motif 1; other site 278137008071 active site 278137008072 motif 2; other site 278137008073 motif 3; other site 278137008074 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 278137008075 anticodon binding site; other site 278137008076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137008077 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 278137008078 active site 278137008079 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 278137008080 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278137008081 Zn2+ binding site [ion binding]; other site 278137008082 Mg2+ binding site [ion binding]; other site 278137008083 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 278137008084 synthetase active site [active] 278137008085 NTP binding site [chemical binding]; other site 278137008086 metal binding site [ion binding]; metal-binding site 278137008087 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 278137008088 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 278137008089 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137008090 active site 278137008091 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 278137008092 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 278137008093 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 278137008094 Protein export membrane protein; Region: SecD_SecF; cl14618 278137008095 protein-export membrane protein SecD; Region: secD; TIGR01129 278137008096 Protein export membrane protein; Region: SecD_SecF; cl14618 278137008097 Preprotein translocase subunit; Region: YajC; cl00806 278137008098 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 278137008099 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137008100 inhibitor-cofactor binding pocket; inhibition site 278137008101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137008102 catalytic residue [active] 278137008103 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137008104 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 278137008105 tetrameric interface [polypeptide binding]; other site 278137008106 NAD binding site [chemical binding]; other site 278137008107 catalytic residues [active] 278137008108 substrate binding site [chemical binding]; other site 278137008109 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137008110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137008111 metal binding site [ion binding]; metal-binding site 278137008112 active site 278137008113 I-site; other site 278137008114 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 278137008115 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 278137008116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137008117 Walker A motif; other site 278137008118 ATP binding site [chemical binding]; other site 278137008119 Walker B motif; other site 278137008120 arginine finger; other site 278137008121 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 278137008122 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 278137008123 RuvA N terminal domain; Region: RuvA_N; pfam01330 278137008124 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 278137008125 active site 278137008126 putative DNA-binding cleft [nucleotide binding]; other site 278137008127 dimer interface [polypeptide binding]; other site 278137008128 Transcriptional regulator; Region: Transcrip_reg; cl00361 278137008129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137008130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137008131 active site 278137008132 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 278137008133 predicted active site [active] 278137008134 catalytic triad [active] 278137008135 acyl-CoA thioesterase II; Region: tesB; TIGR00189 278137008136 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 278137008137 active site 278137008138 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 278137008139 catalytic triad [active] 278137008140 dimer interface [polypeptide binding]; other site 278137008141 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 278137008142 active site 278137008143 multimer interface [polypeptide binding]; other site 278137008144 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 278137008145 nudix motif; other site 278137008146 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137008147 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137008148 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 278137008149 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 278137008150 putative acyl-acceptor binding pocket; other site 278137008151 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 278137008152 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 278137008153 nucleotide binding site/active site [active] 278137008154 HIT family signature motif; other site 278137008155 catalytic residue [active] 278137008156 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 278137008157 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 278137008158 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 278137008159 active site 278137008160 dimer interface [polypeptide binding]; other site 278137008161 motif 1; other site 278137008162 motif 2; other site 278137008163 motif 3; other site 278137008164 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 278137008165 anticodon binding site; other site 278137008166 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 278137008167 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137008168 CoenzymeA binding site [chemical binding]; other site 278137008169 subunit interaction site [polypeptide binding]; other site 278137008170 PHB binding site; other site 278137008171 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 278137008172 GAF domain; Region: GAF; cl15785 278137008173 ANTAR domain; Region: ANTAR; cl04297 278137008174 GAF domain; Region: GAF_2; pfam13185 278137008175 GAF domain; Region: GAF; cl15785 278137008176 Histidine kinase; Region: HisKA_3; pfam07730 278137008177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137008178 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 278137008179 hypothetical protein; Provisional; Region: PRK07877 278137008180 dimer interface [polypeptide binding]; other site 278137008181 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137008182 Ligand Binding Site [chemical binding]; other site 278137008183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 278137008184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137008185 active site 278137008186 phosphorylation site [posttranslational modification] 278137008187 intermolecular recognition site; other site 278137008188 dimerization interface [polypeptide binding]; other site 278137008189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137008190 DNA binding residues [nucleotide binding] 278137008191 dimerization interface [polypeptide binding]; other site 278137008192 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 278137008193 hypothetical protein; Provisional; Region: PRK14851 278137008194 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 278137008195 active site 278137008196 catalytic site [active] 278137008197 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 278137008198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137008199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137008200 dimer interface [polypeptide binding]; other site 278137008201 conserved gate region; other site 278137008202 putative PBP binding loops; other site 278137008203 ABC-ATPase subunit interface; other site 278137008204 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 278137008205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137008206 dimer interface [polypeptide binding]; other site 278137008207 conserved gate region; other site 278137008208 putative PBP binding loops; other site 278137008209 ABC-ATPase subunit interface; other site 278137008210 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 278137008211 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 278137008212 Walker A/P-loop; other site 278137008213 ATP binding site [chemical binding]; other site 278137008214 Q-loop/lid; other site 278137008215 ABC transporter signature motif; other site 278137008216 Walker B; other site 278137008217 D-loop; other site 278137008218 H-loop/switch region; other site 278137008219 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137008220 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 278137008221 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137008222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 278137008223 PAS domain; Region: PAS_9; pfam13426 278137008224 putative active site [active] 278137008225 heme pocket [chemical binding]; other site 278137008226 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 278137008227 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 278137008228 DNA binding residues [nucleotide binding] 278137008229 TOBE domain; Region: TOBE_2; cl01440 278137008230 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 278137008231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137008232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137008233 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 278137008234 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137008235 Walker A/P-loop; other site 278137008236 ATP binding site [chemical binding]; other site 278137008237 Q-loop/lid; other site 278137008238 ABC transporter signature motif; other site 278137008239 Walker B; other site 278137008240 D-loop; other site 278137008241 H-loop/switch region; other site 278137008242 OpgC protein; Region: OpgC_C; cl00792 278137008243 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 278137008244 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 278137008245 AMP-binding enzyme; Region: AMP-binding; cl15778 278137008246 PE-PPE domain; Region: PE-PPE; pfam08237 278137008247 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 278137008248 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137008249 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 278137008250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008251 NAD(P) binding site [chemical binding]; other site 278137008252 active site 278137008253 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 278137008254 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 278137008255 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 278137008256 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137008257 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 278137008258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137008259 DNA binding residues [nucleotide binding] 278137008260 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 278137008261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137008262 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 278137008263 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137008264 DNA binding residues [nucleotide binding] 278137008265 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278137008266 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 278137008267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137008268 putative ADP-binding pocket [chemical binding]; other site 278137008269 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278137008270 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 278137008271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137008272 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137008273 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 278137008274 Helix-turn-helix domains; Region: HTH; cl00088 278137008275 Response regulator receiver domain; Region: Response_reg; pfam00072 278137008276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137008277 active site 278137008278 phosphorylation site [posttranslational modification] 278137008279 intermolecular recognition site; other site 278137008280 dimerization interface [polypeptide binding]; other site 278137008281 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137008282 anti sigma factor interaction site; other site 278137008283 regulatory phosphorylation site [posttranslational modification]; other site 278137008284 CsbD-like; Region: CsbD; cl15799 278137008285 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 278137008286 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 278137008287 putative ligand binding residues [chemical binding]; other site 278137008288 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 278137008289 dimer interface [polypeptide binding]; other site 278137008290 putative PBP binding regions; other site 278137008291 ABC-ATPase subunit interface; other site 278137008292 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 278137008293 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 278137008294 Walker A/P-loop; other site 278137008295 ATP binding site [chemical binding]; other site 278137008296 Q-loop/lid; other site 278137008297 ABC transporter signature motif; other site 278137008298 Walker B; other site 278137008299 D-loop; other site 278137008300 H-loop/switch region; other site 278137008301 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 278137008302 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137008303 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137008304 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 278137008305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137008306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137008307 active site 278137008308 phosphorylation site [posttranslational modification] 278137008309 intermolecular recognition site; other site 278137008310 dimerization interface [polypeptide binding]; other site 278137008311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137008312 DNA binding site [nucleotide binding] 278137008313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 278137008314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137008315 dimer interface [polypeptide binding]; other site 278137008316 phosphorylation site [posttranslational modification] 278137008317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137008318 Mg2+ binding site [ion binding]; other site 278137008319 G-X-G motif; other site 278137008320 Domain of unknown function (DUF305); Region: DUF305; cl15795 278137008321 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 278137008322 Phage capsid family; Region: Phage_capsid; pfam05065 278137008323 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278137008324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137008325 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137008326 hydrophobic ligand binding site; other site 278137008327 Clp protease ATP binding subunit; Region: clpC; CHL00095 278137008328 Clp amino terminal domain; Region: Clp_N; pfam02861 278137008329 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 278137008330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137008331 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 278137008332 DNA binding site [nucleotide binding] 278137008333 active site 278137008334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278137008335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137008336 Coenzyme A binding pocket [chemical binding]; other site 278137008337 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 278137008338 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 278137008339 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 278137008340 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137008341 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 278137008342 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 278137008343 SelR domain; Region: SelR; pfam01641 278137008344 Chlorite dismutase; Region: Chlor_dismutase; cl01280 278137008345 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 278137008346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008347 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 278137008348 substrate binding site [chemical binding]; other site 278137008349 active site 278137008350 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 278137008351 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 278137008352 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 278137008353 catalytic site [active] 278137008354 putative active site [active] 278137008355 putative substrate binding site [chemical binding]; other site 278137008356 HRDC domain; Region: HRDC; cl02578 278137008357 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137008358 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 278137008359 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 278137008360 TPP-binding site; other site 278137008361 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 278137008362 PYR/PP interface [polypeptide binding]; other site 278137008363 dimer interface [polypeptide binding]; other site 278137008364 TPP binding site [chemical binding]; other site 278137008365 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 278137008366 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 278137008367 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 278137008368 TRAM domain; Region: TRAM; cl01282 278137008369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137008370 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 278137008371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008372 potassium/proton antiporter; Reviewed; Region: PRK05326 278137008373 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 278137008374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008375 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 278137008376 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 278137008377 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 278137008378 generic binding surface II; other site 278137008379 ssDNA binding site; other site 278137008380 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137008381 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 278137008382 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 278137008383 trimer interface [polypeptide binding]; other site 278137008384 active site 278137008385 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 278137008386 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 278137008387 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 278137008388 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 278137008389 active site 278137008390 dimerization interface [polypeptide binding]; other site 278137008391 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278137008392 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278137008393 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 278137008394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137008395 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 278137008396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137008397 DNA binding residues [nucleotide binding] 278137008398 O-methyltransferase; Region: Methyltransf_2; pfam00891 278137008399 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 278137008400 homotrimer interaction site [polypeptide binding]; other site 278137008401 putative active site [active] 278137008402 Protein of unknown function (DUF952); Region: DUF952; cl01393 278137008403 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 278137008404 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 278137008405 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 278137008406 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 278137008407 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 278137008408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137008409 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 278137008410 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137008411 DNA binding residues [nucleotide binding] 278137008412 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 278137008413 Helix-turn-helix domains; Region: HTH; cl00088 278137008414 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 278137008415 FeoA domain; Region: FeoA; cl00838 278137008416 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 278137008417 PAC2 family; Region: PAC2; cl00847 278137008418 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137008419 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137008420 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137008421 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 278137008422 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 278137008423 ATP cone domain; Region: ATP-cone; pfam03477 278137008424 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 278137008425 Helix-turn-helix domains; Region: HTH; cl00088 278137008426 LexA repressor; Validated; Region: PRK00215 278137008427 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 278137008428 Catalytic site [active] 278137008429 LGFP repeat; Region: LGFP; pfam08310 278137008430 LGFP repeat; Region: LGFP; pfam08310 278137008431 LGFP repeat; Region: LGFP; pfam08310 278137008432 LGFP repeat; Region: LGFP; pfam08310 278137008433 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 278137008434 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 278137008435 molybdopterin cofactor binding site [chemical binding]; other site 278137008436 substrate binding site [chemical binding]; other site 278137008437 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 278137008438 molybdopterin cofactor binding site; other site 278137008439 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 278137008440 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278137008441 ATP binding site [chemical binding]; other site 278137008442 Mg++ binding site [ion binding]; other site 278137008443 motif III; other site 278137008444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137008445 nucleotide binding region [chemical binding]; other site 278137008446 ATP-binding site [chemical binding]; other site 278137008447 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 278137008448 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 278137008449 HflX GTPase family; Region: HflX; cd01878 278137008450 G1 box; other site 278137008451 GTP/Mg2+ binding site [chemical binding]; other site 278137008452 Switch I region; other site 278137008453 G2 box; other site 278137008454 G3 box; other site 278137008455 Switch II region; other site 278137008456 G4 box; other site 278137008457 G5 box; other site 278137008458 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 278137008459 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 278137008460 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 278137008461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137008462 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 278137008463 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 278137008464 active site 278137008465 metal binding site [ion binding]; metal-binding site 278137008466 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 278137008467 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 278137008468 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 278137008469 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 278137008470 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 278137008471 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 278137008472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137008473 FeS/SAM binding site; other site 278137008474 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278137008475 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 278137008476 Walker A/P-loop; other site 278137008477 ATP binding site [chemical binding]; other site 278137008478 Q-loop/lid; other site 278137008479 ABC transporter signature motif; other site 278137008480 Walker B; other site 278137008481 D-loop; other site 278137008482 H-loop/switch region; other site 278137008483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137008484 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278137008485 substrate binding pocket [chemical binding]; other site 278137008486 membrane-bound complex binding site; other site 278137008487 hinge residues; other site 278137008488 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278137008489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137008490 dimer interface [polypeptide binding]; other site 278137008491 conserved gate region; other site 278137008492 putative PBP binding loops; other site 278137008493 ABC-ATPase subunit interface; other site 278137008494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137008495 dimer interface [polypeptide binding]; other site 278137008496 conserved gate region; other site 278137008497 putative PBP binding loops; other site 278137008498 ABC-ATPase subunit interface; other site 278137008499 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 278137008500 RecX family; Region: RecX; cl00936 278137008501 recombinase A; Provisional; Region: recA; PRK09354 278137008502 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 278137008503 hexamer interface [polypeptide binding]; other site 278137008504 Walker A motif; other site 278137008505 ATP binding site [chemical binding]; other site 278137008506 Walker B motif; other site 278137008507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137008508 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137008509 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 278137008510 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 278137008511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137008512 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 278137008513 Acylphosphatase; Region: Acylphosphatase; cl00551 278137008514 HypF finger; Region: zf-HYPF; pfam07503 278137008515 HypF finger; Region: zf-HYPF; pfam07503 278137008516 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 278137008517 HupF/HypC family; Region: HupF_HypC; cl00394 278137008518 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 278137008519 Hydrogenase formation hypA family; Region: HypD; cl12072 278137008520 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 278137008521 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 278137008522 dimerization interface [polypeptide binding]; other site 278137008523 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 278137008524 ATP binding site [chemical binding]; other site 278137008525 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 278137008526 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 278137008527 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 278137008528 homodimer interface [polypeptide binding]; other site 278137008529 active site 278137008530 TDP-binding site; other site 278137008531 acceptor substrate-binding pocket; other site 278137008532 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137008533 PspA/IM30 family; Region: PspA_IM30; pfam04012 278137008534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137008535 non-specific DNA binding site [nucleotide binding]; other site 278137008536 salt bridge; other site 278137008537 sequence-specific DNA binding site [nucleotide binding]; other site 278137008538 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 278137008539 amino-acid N-acetyltransferase; Region: PLN02825 278137008540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137008541 Coenzyme A binding pocket [chemical binding]; other site 278137008542 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 278137008543 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 278137008544 malonyl-CoA binding site [chemical binding]; other site 278137008545 dimer interface [polypeptide binding]; other site 278137008546 active site 278137008547 product binding site; other site 278137008548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137008549 S-adenosylmethionine binding site [chemical binding]; other site 278137008550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137008551 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 278137008552 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 278137008553 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137008554 classical (c) SDRs; Region: SDR_c; cd05233 278137008555 NAD(P) binding site [chemical binding]; other site 278137008556 active site 278137008557 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137008558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137008559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137008560 active site 278137008561 phosphorylation site [posttranslational modification] 278137008562 intermolecular recognition site; other site 278137008563 dimerization interface [polypeptide binding]; other site 278137008564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137008565 DNA binding site [nucleotide binding] 278137008566 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 278137008567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137008568 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 278137008569 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 278137008570 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 278137008571 dimer interface [polypeptide binding]; other site 278137008572 active site 278137008573 catalytic residue [active] 278137008574 Thymidylate synthase complementing protein; Region: Thy1; cl03630 278137008575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137008576 metal binding site [ion binding]; metal-binding site 278137008577 active site 278137008578 I-site; other site 278137008579 haloalkane dehalogenase; Provisional; Region: PRK00870 278137008580 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 278137008581 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 278137008582 folate binding site [chemical binding]; other site 278137008583 NADP+ binding site [chemical binding]; other site 278137008584 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 278137008585 dimerization interface [polypeptide binding]; other site 278137008586 active site 278137008587 Dienelactone hydrolase family; Region: DLH; pfam01738 278137008588 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137008589 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278137008590 dihydrodipicolinate reductase; Provisional; Region: PRK00048 278137008591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008592 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 278137008593 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137008594 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137008595 active site 278137008596 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 278137008597 Helix-turn-helix domains; Region: HTH; cl00088 278137008598 AsnC family; Region: AsnC_trans_reg; pfam01037 278137008599 alanine dehydrogenase; Region: alaDH; TIGR00518 278137008600 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 278137008601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008602 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 278137008603 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137008604 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 278137008605 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137008606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 278137008607 SEC-C motif; Region: SEC-C; pfam02810 278137008608 GXWXG protein; Region: GXWXG; pfam14231 278137008609 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 278137008610 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 278137008611 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137008612 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 278137008613 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 278137008614 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 278137008615 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 278137008616 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 278137008617 oligomer interface [polypeptide binding]; other site 278137008618 RNA binding site [nucleotide binding]; other site 278137008619 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 278137008620 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 278137008621 RNase E interface [polypeptide binding]; other site 278137008622 trimer interface [polypeptide binding]; other site 278137008623 active site 278137008624 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 278137008625 putative nucleic acid binding region [nucleotide binding]; other site 278137008626 G-X-X-G motif; other site 278137008627 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 278137008628 RNA binding site [nucleotide binding]; other site 278137008629 domain interface; other site 278137008630 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 278137008631 16S/18S rRNA binding site [nucleotide binding]; other site 278137008632 S13e-L30e interaction site [polypeptide binding]; other site 278137008633 25S rRNA binding site [nucleotide binding]; other site 278137008634 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 278137008635 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 278137008636 active site 278137008637 Riboflavin kinase; Region: Flavokinase; cl03312 278137008638 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 278137008639 Helix-turn-helix domains; Region: HTH; cl00088 278137008640 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 278137008641 FeoA domain; Region: FeoA; cl00838 278137008642 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 278137008643 hydrophobic ligand binding site; other site 278137008644 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 278137008645 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 278137008646 RNA binding site [nucleotide binding]; other site 278137008647 active site 278137008648 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 278137008649 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 278137008650 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 278137008651 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 278137008652 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 278137008653 active site 278137008654 metal binding site [ion binding]; metal-binding site 278137008655 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 278137008656 Predicted acyl esterases [General function prediction only]; Region: COG2936 278137008657 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 278137008658 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 278137008659 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 278137008660 enoyl-CoA hydratase; Provisional; Region: PRK06190 278137008661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137008662 substrate binding site [chemical binding]; other site 278137008663 oxyanion hole (OAH) forming residues; other site 278137008664 trimer interface [polypeptide binding]; other site 278137008665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137008666 S-adenosylmethionine binding site [chemical binding]; other site 278137008667 putative efflux protein, MATE family; Region: matE; TIGR00797 278137008668 MatE; Region: MatE; cl10513 278137008669 MatE; Region: MatE; cl10513 278137008670 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 278137008671 DHH family; Region: DHH; pfam01368 278137008672 Ribosome-binding factor A; Region: RBFA; cl00542 278137008673 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278137008674 translation initiation factor IF-2; Region: IF-2; TIGR00487 278137008675 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278137008676 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 278137008677 G1 box; other site 278137008678 putative GEF interaction site [polypeptide binding]; other site 278137008679 GTP/Mg2+ binding site [chemical binding]; other site 278137008680 Switch I region; other site 278137008681 G2 box; other site 278137008682 G3 box; other site 278137008683 Switch II region; other site 278137008684 G4 box; other site 278137008685 G5 box; other site 278137008686 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 278137008687 Translation-initiation factor 2; Region: IF-2; pfam11987 278137008688 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 278137008689 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 278137008690 putative RNA binding cleft [nucleotide binding]; other site 278137008691 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 278137008692 NusA N-terminal domain; Region: NusA_N; pfam08529 278137008693 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 278137008694 RNA binding site [nucleotide binding]; other site 278137008695 homodimer interface [polypeptide binding]; other site 278137008696 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 278137008697 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 278137008698 G-X-X-G motif; other site 278137008699 ribosome maturation protein RimP; Reviewed; Region: PRK00092 278137008700 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 278137008701 Sm1 motif; other site 278137008702 D1 - D2 interaction site; other site 278137008703 D3 - B interaction site; other site 278137008704 Hfq - Hfq interaction site; other site 278137008705 RNA binding pocket [nucleotide binding]; other site 278137008706 Sm2 motif; other site 278137008707 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 278137008708 dinuclear metal binding motif [ion binding]; other site 278137008709 prolyl-tRNA synthetase; Provisional; Region: PRK09194 278137008710 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 278137008711 dimer interface [polypeptide binding]; other site 278137008712 motif 1; other site 278137008713 active site 278137008714 motif 2; other site 278137008715 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 278137008716 putative deacylase active site [active] 278137008717 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 278137008718 active site 278137008719 motif 3; other site 278137008720 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 278137008721 anticodon binding site; other site 278137008722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137008723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278137008724 putative substrate translocation pore; other site 278137008725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008726 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 278137008727 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 278137008728 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 278137008729 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137008730 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 278137008731 catalytic triad [active] 278137008732 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 278137008733 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 278137008734 Walker A motif; other site 278137008735 homodimer interface [polypeptide binding]; other site 278137008736 ATP binding site [chemical binding]; other site 278137008737 hydroxycobalamin binding site [chemical binding]; other site 278137008738 Walker B motif; other site 278137008739 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 278137008740 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137008741 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 278137008742 metal ion-dependent adhesion site (MIDAS); other site 278137008743 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137008744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008745 Predicted dehydrogenase [General function prediction only]; Region: COG0579 278137008746 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 278137008747 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137008748 mycothione reductase; Reviewed; Region: PRK07846 278137008749 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137008750 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278137008751 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 278137008752 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 278137008753 Walker A/P-loop; other site 278137008754 ATP binding site [chemical binding]; other site 278137008755 Q-loop/lid; other site 278137008756 ABC transporter signature motif; other site 278137008757 Walker B; other site 278137008758 D-loop; other site 278137008759 H-loop/switch region; other site 278137008760 Cobalt transport protein; Region: CbiQ; cl00463 278137008761 PDGLE domain; Region: PDGLE; cl07986 278137008762 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 278137008763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137008764 dimerization interface [polypeptide binding]; other site 278137008765 putative DNA binding site [nucleotide binding]; other site 278137008766 putative Zn2+ binding site [ion binding]; other site 278137008767 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 278137008768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137008769 Transcriptional regulators [Transcription]; Region: FadR; COG2186 278137008770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137008771 DNA-binding site [nucleotide binding]; DNA binding site 278137008772 FCD domain; Region: FCD; cl11656 278137008773 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 278137008774 classical (c) SDRs; Region: SDR_c; cd05233 278137008775 NAD(P) binding site [chemical binding]; other site 278137008776 active site 278137008777 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137008778 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 278137008779 NAD(P) binding site [chemical binding]; other site 278137008780 catalytic residues [active] 278137008781 Peptidase C26; Region: Peptidase_C26; pfam07722 278137008782 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 278137008783 catalytic triad [active] 278137008784 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 278137008785 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 278137008786 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 278137008787 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 278137008788 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 278137008789 dimer interface [polypeptide binding]; other site 278137008790 active site 278137008791 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 278137008792 Ligand Binding Site [chemical binding]; other site 278137008793 Molecular Tunnel; other site 278137008794 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 278137008795 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137008796 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137008797 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 278137008798 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 278137008799 active site 278137008800 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137008801 CoenzymeA binding site [chemical binding]; other site 278137008802 subunit interaction site [polypeptide binding]; other site 278137008803 PHB binding site; other site 278137008804 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 278137008805 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 278137008806 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 278137008807 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 278137008808 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137008809 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278137008810 Predicted acetyltransferase [General function prediction only]; Region: COG3393 278137008811 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 278137008812 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137008813 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 278137008814 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 278137008815 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 278137008816 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 278137008817 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 278137008818 active site 278137008819 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 278137008820 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 278137008821 putative substrate binding region [chemical binding]; other site 278137008822 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 278137008823 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 278137008824 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 278137008825 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 278137008826 Fasciclin domain; Region: Fasciclin; cl02663 278137008827 Fasciclin domain; Region: Fasciclin; cl02663 278137008828 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 278137008829 DNA photolyase; Region: DNA_photolyase; pfam00875 278137008830 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 278137008831 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137008832 classical (c) SDRs; Region: SDR_c; cd05233 278137008833 NAD(P) binding site [chemical binding]; other site 278137008834 active site 278137008835 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 278137008836 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 278137008837 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137008838 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 278137008839 Domain of unknown function (DUF427); Region: DUF427; cl00998 278137008840 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 278137008841 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 278137008842 active site 278137008843 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 278137008844 catalytic triad [active] 278137008845 dimer interface [polypeptide binding]; other site 278137008846 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 278137008847 Prostaglandin dehydrogenases; Region: PGDH; cd05288 278137008848 NAD(P) binding site [chemical binding]; other site 278137008849 substrate binding site [chemical binding]; other site 278137008850 dimer interface [polypeptide binding]; other site 278137008851 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 278137008852 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 278137008853 Helix-turn-helix domains; Region: HTH; cl00088 278137008854 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 278137008855 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137008856 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137008857 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 278137008858 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137008859 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137008860 active site 278137008861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137008862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137008863 active site 278137008864 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137008865 acetyl esterase; Provisional; Region: PRK10162 278137008866 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137008867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008868 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137008869 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137008870 classical (c) SDRs; Region: SDR_c; cd05233 278137008871 NAD(P) binding site [chemical binding]; other site 278137008872 active site 278137008873 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137008874 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 278137008875 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137008876 NAD(P) binding site [chemical binding]; other site 278137008877 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137008878 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 278137008879 Strictosidine synthase; Region: Str_synth; pfam03088 278137008880 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 278137008881 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 278137008882 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 278137008883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137008884 Helix-turn-helix domains; Region: HTH; cl00088 278137008885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137008886 Helix-turn-helix domains; Region: HTH; cl00088 278137008887 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 278137008888 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 278137008889 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137008890 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137008891 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137008892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137008893 Helix-turn-helix domains; Region: HTH; cl00088 278137008894 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137008895 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 278137008896 NAD binding site [chemical binding]; other site 278137008897 catalytic residues [active] 278137008898 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137008899 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 278137008900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137008901 FeS/SAM binding site; other site 278137008902 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 278137008903 ribosome recycling factor; Reviewed; Region: frr; PRK00083 278137008904 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 278137008905 hinge region; other site 278137008906 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 278137008907 putative nucleotide binding site [chemical binding]; other site 278137008908 uridine monophosphate binding site [chemical binding]; other site 278137008909 homohexameric interface [polypeptide binding]; other site 278137008910 tyramine oxidase; Provisional; Region: tynA; PRK11504 278137008911 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 278137008912 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 278137008913 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 278137008914 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 278137008915 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278137008916 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 278137008917 Walker A/P-loop; other site 278137008918 ATP binding site [chemical binding]; other site 278137008919 Q-loop/lid; other site 278137008920 ABC transporter signature motif; other site 278137008921 Walker B; other site 278137008922 D-loop; other site 278137008923 H-loop/switch region; other site 278137008924 FtsX-like permease family; Region: FtsX; cl15850 278137008925 amidase; Provisional; Region: PRK07869 278137008926 Amidase; Region: Amidase; cl11426 278137008927 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 278137008928 Bacterial sugar transferase; Region: Bac_transf; cl00939 278137008929 elongation factor Ts; Provisional; Region: tsf; PRK09377 278137008930 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 278137008931 Elongation factor TS; Region: EF_TS; pfam00889 278137008932 Elongation factor TS; Region: EF_TS; pfam00889 278137008933 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 278137008934 rRNA interaction site [nucleotide binding]; other site 278137008935 S8 interaction site; other site 278137008936 putative laminin-1 binding site; other site 278137008937 Peptidase family M23; Region: Peptidase_M23; pfam01551 278137008938 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 278137008939 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137008940 active site 278137008941 DNA binding site [nucleotide binding] 278137008942 Int/Topo IB signature motif; other site 278137008943 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 278137008944 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 278137008945 putative active site [active] 278137008946 putative substrate binding site [chemical binding]; other site 278137008947 putative FMN binding site [chemical binding]; other site 278137008948 putative catalytic residues [active] 278137008949 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 278137008950 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 278137008951 FAD binding pocket [chemical binding]; other site 278137008952 FAD binding motif [chemical binding]; other site 278137008953 phosphate binding motif [ion binding]; other site 278137008954 NAD binding pocket [chemical binding]; other site 278137008955 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 278137008956 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 278137008957 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 278137008958 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 278137008959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137008960 Walker A motif; other site 278137008961 ATP binding site [chemical binding]; other site 278137008962 Walker B motif; other site 278137008963 arginine finger; other site 278137008964 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 278137008965 Restriction endonuclease; Region: Mrr_cat; cl00516 278137008966 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 278137008967 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 278137008968 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 278137008969 acyl-CoA synthetase; Validated; Region: PRK07787 278137008970 AMP-binding enzyme; Region: AMP-binding; cl15778 278137008971 AMP-binding enzyme; Region: AMP-binding; cl15778 278137008972 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137008973 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 278137008974 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 278137008975 active site 278137008976 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 278137008977 catalytic triad [active] 278137008978 dimer interface [polypeptide binding]; other site 278137008979 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 278137008980 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137008981 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137008982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137008983 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137008984 classical (c) SDRs; Region: SDR_c; cd05233 278137008985 NAD(P) binding site [chemical binding]; other site 278137008986 active site 278137008987 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137008988 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137008989 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137008990 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 278137008991 NAD binding site [chemical binding]; other site 278137008992 catalytic residues [active] 278137008993 short chain dehydrogenase; Provisional; Region: PRK06179 278137008994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137008995 NAD(P) binding site [chemical binding]; other site 278137008996 active site 278137008997 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 278137008998 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 278137008999 ligand binding site [chemical binding]; other site 278137009000 replication factor C subunit; Provisional; Region: PLN03025 278137009001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009002 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 278137009003 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 278137009004 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137009005 metal ion-dependent adhesion site (MIDAS); other site 278137009006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137009007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009008 NAD(P) binding site [chemical binding]; other site 278137009009 active site 278137009010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137009011 Helix-turn-helix domains; Region: HTH; cl00088 278137009012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137009013 Helix-turn-helix domains; Region: HTH; cl00088 278137009014 mce related protein; Region: MCE; pfam02470 278137009015 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137009016 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137009017 mce related protein; Region: MCE; pfam02470 278137009018 mce related protein; Region: MCE; pfam02470 278137009019 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137009020 mce related protein; Region: MCE; pfam02470 278137009021 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137009022 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137009023 mce related protein; Region: MCE; pfam02470 278137009024 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137009025 mce related protein; Region: MCE; pfam02470 278137009026 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 278137009027 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 278137009028 RNA/DNA hybrid binding site [nucleotide binding]; other site 278137009029 active site 278137009030 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 278137009031 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 278137009032 Catalytic site [active] 278137009033 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 278137009034 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 278137009035 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137009036 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 278137009037 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 278137009038 RimM N-terminal domain; Region: RimM; pfam01782 278137009039 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 278137009040 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 278137009041 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 278137009042 MgtE intracellular N domain; Region: MgtE_N; cl15244 278137009043 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 278137009044 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 278137009045 Divalent cation transporter; Region: MgtE; cl00786 278137009046 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137009047 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137009048 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 278137009049 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137009050 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 278137009051 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137009052 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 278137009053 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137009054 active site 278137009055 signal recognition particle protein; Provisional; Region: PRK10867 278137009056 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 278137009057 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 278137009058 P loop; other site 278137009059 GTP binding site [chemical binding]; other site 278137009060 Signal peptide binding domain; Region: SRP_SPB; pfam02978 278137009061 PII uridylyl-transferase; Provisional; Region: PRK03381 278137009062 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 278137009063 metal binding triad; other site 278137009064 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 278137009065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278137009066 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 278137009067 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 278137009068 Nitrogen regulatory protein P-II; Region: P-II; cl00412 278137009069 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 278137009070 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 278137009071 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 278137009072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009073 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 278137009074 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 278137009075 homotetramer interface [polypeptide binding]; other site 278137009076 FMN binding site [chemical binding]; other site 278137009077 homodimer contacts [polypeptide binding]; other site 278137009078 putative active site [active] 278137009079 putative substrate binding site [chemical binding]; other site 278137009080 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 278137009081 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 278137009082 Walker A/P-loop; other site 278137009083 ATP binding site [chemical binding]; other site 278137009084 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 278137009085 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 278137009086 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 278137009087 ABC transporter signature motif; other site 278137009088 Walker B; other site 278137009089 D-loop; other site 278137009090 H-loop/switch region; other site 278137009091 Acylphosphatase; Region: Acylphosphatase; cl00551 278137009092 OsmC-like protein; Region: OsmC; cl00767 278137009093 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 278137009094 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 278137009095 DNA binding site [nucleotide binding] 278137009096 catalytic residue [active] 278137009097 H2TH interface [polypeptide binding]; other site 278137009098 putative catalytic residues [active] 278137009099 turnover-facilitating residue; other site 278137009100 intercalation triad [nucleotide binding]; other site 278137009101 8OG recognition residue [nucleotide binding]; other site 278137009102 putative reading head residues; other site 278137009103 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 278137009104 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 278137009105 ribonuclease III; Reviewed; Region: rnc; PRK00102 278137009106 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 278137009107 dimerization interface [polypeptide binding]; other site 278137009108 active site 278137009109 metal binding site [ion binding]; metal-binding site 278137009110 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 278137009111 dsRNA binding site [nucleotide binding]; other site 278137009112 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 278137009113 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 278137009114 Plant ATP synthase F0; Region: YMF19; cl07975 278137009115 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 278137009116 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 278137009117 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 278137009118 active site 278137009119 (T/H)XGH motif; other site 278137009120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137009121 S-adenosylmethionine binding site [chemical binding]; other site 278137009122 pyruvate carboxylase; Reviewed; Region: PRK12999 278137009123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278137009124 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137009125 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 278137009126 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 278137009127 active site 278137009128 catalytic residues [active] 278137009129 metal binding site [ion binding]; metal-binding site 278137009130 homodimer binding site [polypeptide binding]; other site 278137009131 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278137009132 carboxyltransferase (CT) interaction site; other site 278137009133 biotinylation site [posttranslational modification]; other site 278137009134 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137009135 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137009136 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137009137 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137009138 Vitamin K epoxide reductase family; Region: VKOR; cl01729 278137009139 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 278137009140 catalytic residues [active] 278137009141 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137009142 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137009143 substrate binding pocket [chemical binding]; other site 278137009144 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137009145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278137009146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278137009147 active site 278137009148 catalytic tetrad [active] 278137009149 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 278137009150 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 278137009151 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 278137009152 Protein of unknown function (DUF461); Region: DUF461; cl01071 278137009153 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 278137009154 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 278137009155 Protein of unknown function DUF262; Region: DUF262; cl14890 278137009156 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 278137009157 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 278137009158 generic binding surface II; other site 278137009159 ssDNA binding site; other site 278137009160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137009161 ATP binding site [chemical binding]; other site 278137009162 putative Mg++ binding site [ion binding]; other site 278137009163 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137009164 nucleotide binding region [chemical binding]; other site 278137009165 ATP-binding site [chemical binding]; other site 278137009166 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 278137009167 DAK2 domain; Region: Dak2; cl03685 278137009168 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 278137009169 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 278137009170 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 278137009171 ligand binding site [chemical binding]; other site 278137009172 active site 278137009173 UGI interface [polypeptide binding]; other site 278137009174 catalytic site [active] 278137009175 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 278137009176 ATP binding site [chemical binding]; other site 278137009177 dimerization interface [polypeptide binding]; other site 278137009178 Helix-turn-helix domains; Region: HTH; cl00088 278137009179 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 278137009180 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 278137009181 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 278137009182 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137009183 cystathionine gamma-lyase; Validated; Region: PRK07582 278137009184 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137009185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137009186 catalytic residue [active] 278137009187 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 278137009188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009189 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 278137009190 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137009191 polyphosphate kinase; Provisional; Region: PRK05443 278137009192 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 278137009193 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 278137009194 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 278137009195 putative domain interface [polypeptide binding]; other site 278137009196 putative active site [active] 278137009197 catalytic site [active] 278137009198 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 278137009199 putative active site [active] 278137009200 catalytic site [active] 278137009201 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 278137009202 active site 278137009203 Ap6A binding site [chemical binding]; other site 278137009204 nudix motif; other site 278137009205 metal binding site [ion binding]; metal-binding site 278137009206 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137009207 catalytic core [active] 278137009208 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 278137009209 IHF - DNA interface [nucleotide binding]; other site 278137009210 IHF dimer interface [polypeptide binding]; other site 278137009211 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 278137009212 substrate binding site [chemical binding]; other site 278137009213 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 278137009214 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 278137009215 substrate binding site [chemical binding]; other site 278137009216 ligand binding site [chemical binding]; other site 278137009217 Transcriptional regulator [Transcription]; Region: IclR; COG1414 278137009218 Helix-turn-helix domains; Region: HTH; cl00088 278137009219 Bacterial transcriptional regulator; Region: IclR; pfam01614 278137009220 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 278137009221 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 278137009222 HIGH motif; other site 278137009223 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 278137009224 active site 278137009225 KMSKS motif; other site 278137009226 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 278137009227 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 278137009228 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 278137009229 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 278137009230 tartrate dehydrogenase; Provisional; Region: PRK08194 278137009231 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 278137009232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009233 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 278137009234 putative L-serine binding site [chemical binding]; other site 278137009235 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 278137009236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009237 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 278137009238 ketol-acid reductoisomerase; Provisional; Region: PRK05479 278137009239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009240 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 278137009241 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 278137009242 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 278137009243 putative valine binding site [chemical binding]; other site 278137009244 dimer interface [polypeptide binding]; other site 278137009245 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 278137009246 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 278137009247 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 278137009248 PYR/PP interface [polypeptide binding]; other site 278137009249 dimer interface [polypeptide binding]; other site 278137009250 TPP binding site [chemical binding]; other site 278137009251 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 278137009252 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 278137009253 TPP-binding site [chemical binding]; other site 278137009254 dimer interface [polypeptide binding]; other site 278137009255 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 278137009256 DoxX; Region: DoxX; cl00976 278137009257 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 278137009258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 278137009259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 278137009260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137009261 dimer interface [polypeptide binding]; other site 278137009262 phosphorylation site [posttranslational modification] 278137009263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137009264 ATP binding site [chemical binding]; other site 278137009265 Mg2+ binding site [ion binding]; other site 278137009266 G-X-G motif; other site 278137009267 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 278137009268 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 278137009269 GatB domain; Region: GatB_Yqey; cl11497 278137009270 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cd00363 278137009271 active site 278137009272 ADP/pyrophosphate binding site [chemical binding]; other site 278137009273 dimerization interface [polypeptide binding]; other site 278137009274 allosteric effector site; other site 278137009275 fructose-1,6-bisphosphate binding site; other site 278137009276 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 278137009277 Amidase; Region: Amidase; cl11426 278137009278 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 278137009279 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 278137009280 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 278137009281 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 278137009282 nucleotide binding pocket [chemical binding]; other site 278137009283 K-X-D-G motif; other site 278137009284 catalytic site [active] 278137009285 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 278137009286 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 278137009287 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 278137009288 Dimer interface [polypeptide binding]; other site 278137009289 BRCT sequence motif; other site 278137009290 Protein of unknown function (DUF419); Region: DUF419; cl15265 278137009291 4-coumarate--CoA ligase; Region: PLN02246 278137009292 AMP-binding enzyme; Region: AMP-binding; cl15778 278137009293 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137009294 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 278137009295 GAF domain; Region: GAF; cl15785 278137009296 PAS fold; Region: PAS_4; pfam08448 278137009297 PAS fold; Region: PAS; pfam00989 278137009298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 278137009299 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137009300 metal binding site [ion binding]; metal-binding site 278137009301 active site 278137009302 I-site; other site 278137009303 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 278137009304 PknH-like extracellular domain; Region: PknH_C; pfam14032 278137009305 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 278137009306 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 278137009307 Ligand Binding Site [chemical binding]; other site 278137009308 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137009309 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 278137009310 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137009311 catalytic residue [active] 278137009312 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 278137009313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 278137009314 putative acyl-acceptor binding pocket; other site 278137009315 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137009316 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 278137009317 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 278137009318 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 278137009319 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 278137009320 Ligand binding site [chemical binding]; other site 278137009321 Electron transfer flavoprotein domain; Region: ETF; pfam01012 278137009322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137009323 S-adenosylmethionine binding site [chemical binding]; other site 278137009324 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 278137009325 Uncharacterized conserved protein [Function unknown]; Region: COG1543 278137009326 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 278137009327 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 278137009328 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137009329 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137009330 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 278137009331 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 278137009332 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 278137009333 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 278137009334 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 278137009335 trimer interface [polypeptide binding]; other site 278137009336 active site 278137009337 substrate binding site [chemical binding]; other site 278137009338 CoA binding site [chemical binding]; other site 278137009339 FOG: WD40-like repeat [Function unknown]; Region: COG1520 278137009340 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 278137009341 active site 278137009342 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 278137009343 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 278137009344 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 278137009345 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 278137009346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137009347 S-adenosylmethionine binding site [chemical binding]; other site 278137009348 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137009349 substrate binding site [chemical binding]; other site 278137009350 oxyanion hole (OAH) forming residues; other site 278137009351 trimer interface [polypeptide binding]; other site 278137009352 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 278137009353 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 278137009354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009355 Walker A/P-loop; other site 278137009356 ATP binding site [chemical binding]; other site 278137009357 Q-loop/lid; other site 278137009358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009359 ABC transporter signature motif; other site 278137009360 ABC transporter signature motif; other site 278137009361 Walker B; other site 278137009362 Walker B; other site 278137009363 D-loop; other site 278137009364 D-loop; other site 278137009365 H-loop/switch region; other site 278137009366 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 278137009367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009368 active site 278137009369 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278137009370 Predicted membrane protein [Function unknown]; Region: COG2364 278137009371 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 278137009372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137009373 DNA-binding site [nucleotide binding]; DNA binding site 278137009374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278137009375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137009376 homodimer interface [polypeptide binding]; other site 278137009377 catalytic residue [active] 278137009378 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 278137009379 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 278137009380 phosphoserine phosphatase SerB; Region: serB; TIGR00338 278137009381 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137009382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137009383 motif II; other site 278137009384 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 278137009385 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 278137009386 D-pathway; other site 278137009387 Putative ubiquinol binding site [chemical binding]; other site 278137009388 Low-spin heme (heme b) binding site [chemical binding]; other site 278137009389 Putative water exit pathway; other site 278137009390 Binuclear center (heme o3/CuB) [ion binding]; other site 278137009391 K-pathway; other site 278137009392 Putative proton exit pathway; other site 278137009393 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 278137009394 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 278137009395 siderophore binding site; other site 278137009396 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 278137009397 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 278137009398 putative NAD(P) binding site [chemical binding]; other site 278137009399 putative substrate binding site [chemical binding]; other site 278137009400 catalytic Zn binding site [ion binding]; other site 278137009401 structural Zn binding site [ion binding]; other site 278137009402 dimer interface [polypeptide binding]; other site 278137009403 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 278137009404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137009405 Helix-turn-helix domains; Region: HTH; cl00088 278137009406 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137009407 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 278137009408 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 278137009409 dimer interface [polypeptide binding]; other site 278137009410 putative radical transfer pathway; other site 278137009411 diiron center [ion binding]; other site 278137009412 tyrosyl radical; other site 278137009413 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137009414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009415 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 278137009416 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 278137009417 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 278137009418 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 278137009419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137009420 DNA binding residues [nucleotide binding] 278137009421 dimerization interface [polypeptide binding]; other site 278137009422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137009423 Helix-turn-helix domains; Region: HTH; cl00088 278137009424 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 278137009425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009426 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 278137009427 active site 278137009428 nucleophile elbow; other site 278137009429 TIR domain; Region: TIR_2; cl15770 278137009430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009431 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 278137009432 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 278137009433 structural tetrad; other site 278137009434 FOG: WD40 repeat [General function prediction only]; Region: COG2319 278137009435 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 278137009436 structural tetrad; other site 278137009437 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 278137009438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137009439 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 278137009440 Cupin domain; Region: Cupin_2; cl09118 278137009441 Predicted transcriptional regulator [Transcription]; Region: COG2345 278137009442 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 278137009443 Methyltransferase domain; Region: Methyltransf_31; pfam13847 278137009444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137009445 S-adenosylmethionine binding site [chemical binding]; other site 278137009446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137009447 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 278137009448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009449 Walker A/P-loop; other site 278137009450 ATP binding site [chemical binding]; other site 278137009451 Q-loop/lid; other site 278137009452 ABC transporter signature motif; other site 278137009453 Walker B; other site 278137009454 D-loop; other site 278137009455 H-loop/switch region; other site 278137009456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137009457 dimerization interface [polypeptide binding]; other site 278137009458 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 278137009459 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 278137009460 Class I ribonucleotide reductase; Region: RNR_I; cd01679 278137009461 active site 278137009462 dimer interface [polypeptide binding]; other site 278137009463 catalytic residues [active] 278137009464 effector binding site; other site 278137009465 R2 peptide binding site; other site 278137009466 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278137009467 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 278137009468 catalytic residues [active] 278137009469 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 278137009470 Helix-turn-helix domains; Region: HTH; cl00088 278137009471 DNA polymerase IV; Validated; Region: PRK03352 278137009472 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 278137009473 active site 278137009474 DNA binding site [nucleotide binding] 278137009475 GAF domain; Region: GAF; cl15785 278137009476 Predicted ATPase [General function prediction only]; Region: COG4637 278137009477 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 278137009478 short chain dehydrogenase; Provisional; Region: PRK07832 278137009479 classical (c) SDRs; Region: SDR_c; cd05233 278137009480 NAD(P) binding site [chemical binding]; other site 278137009481 active site 278137009482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137009483 Helix-turn-helix domains; Region: HTH; cl00088 278137009484 Cytochrome P450; Region: p450; pfam00067 278137009485 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137009486 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 278137009487 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 278137009488 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 278137009489 putative active site [active] 278137009490 putative substrate binding site [chemical binding]; other site 278137009491 ATP binding site [chemical binding]; other site 278137009492 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 278137009493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009494 NAD(P) binding site [chemical binding]; other site 278137009495 active site 278137009496 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 278137009497 Moco binding site; other site 278137009498 metal coordination site [ion binding]; other site 278137009499 dimerization interface [polypeptide binding]; other site 278137009500 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 278137009501 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 278137009502 active site 278137009503 DNA binding site [nucleotide binding] 278137009504 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 278137009505 DNA binding site [nucleotide binding] 278137009506 carbon starvation protein A; Provisional; Region: PRK15015 278137009507 Carbon starvation protein CstA; Region: CstA; pfam02554 278137009508 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 278137009509 Protein of unknown function (DUF466); Region: DUF466; cl01082 278137009510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137009511 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137009512 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 278137009513 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137009514 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 278137009515 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137009516 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137009517 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 278137009518 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137009519 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137009520 Phosphotransferase enzyme family; Region: APH; pfam01636 278137009521 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137009522 active site 278137009523 ATP binding site [chemical binding]; other site 278137009524 substrate binding site [chemical binding]; other site 278137009525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137009526 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137009527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009529 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 278137009530 [2Fe-2S] cluster binding site [ion binding]; other site 278137009531 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 278137009532 catalytic triad [active] 278137009533 conserved cis-peptide bond; other site 278137009534 acyl-CoA synthetase; Validated; Region: PRK07798 278137009535 AMP-binding enzyme; Region: AMP-binding; cl15778 278137009536 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 278137009537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009538 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 278137009539 NAD(P) binding site [chemical binding]; other site 278137009540 active site 278137009541 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137009542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137009543 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 278137009544 NAD binding site [chemical binding]; other site 278137009545 catalytic residues [active] 278137009546 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137009547 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137009548 Integrase core domain; Region: rve; cl01316 278137009549 Integrase core domain; Region: rve_3; cl15866 278137009550 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137009551 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 278137009552 molybdopterin cofactor binding site; other site 278137009553 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 278137009554 molybdopterin cofactor binding site; other site 278137009555 YacP-like NYN domain; Region: NYN_YacP; cl01491 278137009556 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137009557 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 278137009558 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 278137009559 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137009560 active site 278137009561 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137009562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137009563 active site 278137009564 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 278137009565 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137009566 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137009567 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137009568 acyl-CoA synthetase; Validated; Region: PRK07798 278137009569 AMP-binding enzyme; Region: AMP-binding; cl15778 278137009570 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137009571 enoyl-CoA hydratase; Provisional; Region: PRK06210 278137009572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137009573 substrate binding site [chemical binding]; other site 278137009574 oxyanion hole (OAH) forming residues; other site 278137009575 trimer interface [polypeptide binding]; other site 278137009576 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 278137009577 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 278137009578 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 278137009579 active site 278137009580 inhibitor site; inhibition site 278137009581 dimer interface [polypeptide binding]; other site 278137009582 catalytic residue [active] 278137009583 enoyl-CoA hydratase; Provisional; Region: PRK08252 278137009584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137009585 substrate binding site [chemical binding]; other site 278137009586 oxyanion hole (OAH) forming residues; other site 278137009587 trimer interface [polypeptide binding]; other site 278137009588 tetracycline repressor protein TetR; Provisional; Region: PRK13756 278137009589 Helix-turn-helix domains; Region: HTH; cl00088 278137009590 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 278137009591 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137009592 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 278137009593 dimer interface [polypeptide binding]; other site 278137009594 active site 278137009595 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 278137009596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137009597 substrate binding site [chemical binding]; other site 278137009598 oxyanion hole (OAH) forming residues; other site 278137009599 trimer interface [polypeptide binding]; other site 278137009600 Transcriptional regulators [Transcription]; Region: FadR; COG2186 278137009601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137009602 DNA-binding site [nucleotide binding]; DNA binding site 278137009603 FCD domain; Region: FCD; cl11656 278137009604 enoyl-CoA hydratase; Provisional; Region: PRK06688 278137009605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137009606 substrate binding site [chemical binding]; other site 278137009607 oxyanion hole (OAH) forming residues; other site 278137009608 trimer interface [polypeptide binding]; other site 278137009609 enoyl-CoA hydratase; Provisional; Region: PRK06494 278137009610 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137009611 substrate binding site [chemical binding]; other site 278137009612 oxyanion hole (OAH) forming residues; other site 278137009613 trimer interface [polypeptide binding]; other site 278137009614 enoyl-CoA hydratase; Provisional; Region: PRK08290 278137009615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137009616 substrate binding site [chemical binding]; other site 278137009617 oxyanion hole (OAH) forming residues; other site 278137009618 trimer interface [polypeptide binding]; other site 278137009619 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 278137009620 AMP-binding enzyme; Region: AMP-binding; cl15778 278137009621 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 278137009622 AMP-binding enzyme; Region: AMP-binding; cl15778 278137009623 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 278137009624 AMP-binding enzyme; Region: AMP-binding; cl15778 278137009625 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137009626 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137009627 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 278137009628 Transcriptional regulators [Transcription]; Region: FadR; COG2186 278137009629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137009630 DNA-binding site [nucleotide binding]; DNA binding site 278137009631 FCD domain; Region: FCD; cl11656 278137009632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137009633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137009634 active site 278137009635 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 278137009636 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137009637 dimer interface [polypeptide binding]; other site 278137009638 active site 278137009639 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137009640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009641 NAD(P) binding site [chemical binding]; other site 278137009642 active site 278137009643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137009644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137009645 active site 278137009646 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137009647 classical (c) SDRs; Region: SDR_c; cd05233 278137009648 NAD(P) binding site [chemical binding]; other site 278137009649 active site 278137009650 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137009651 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137009652 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137009653 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 278137009654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009655 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 278137009656 putative active site [active] 278137009657 putative catalytic site [active] 278137009658 hypothetical protein; Provisional; Region: PRK07877 278137009659 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 278137009660 ATP binding site [chemical binding]; other site 278137009661 substrate interface [chemical binding]; other site 278137009662 GAF domain; Region: GAF_2; pfam13185 278137009663 GAF domain; Region: GAF; cl15785 278137009664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137009665 metal binding site [ion binding]; metal-binding site 278137009666 active site 278137009667 I-site; other site 278137009668 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137009669 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 278137009670 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 278137009671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137009672 active site 278137009673 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 278137009674 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 278137009675 active site 278137009676 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137009677 Ligand Binding Site [chemical binding]; other site 278137009678 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137009679 Ligand Binding Site [chemical binding]; other site 278137009680 Helix-turn-helix domains; Region: HTH; cl00088 278137009681 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 278137009682 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 278137009683 putative catalytic site [active] 278137009684 putative metal binding site [ion binding]; other site 278137009685 putative phosphate binding site [ion binding]; other site 278137009686 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278137009687 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 278137009688 ligand binding site [chemical binding]; other site 278137009689 flexible hinge region; other site 278137009690 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 278137009691 putative switch regulator; other site 278137009692 non-specific DNA interactions [nucleotide binding]; other site 278137009693 DNA binding site [nucleotide binding] 278137009694 sequence specific DNA binding site [nucleotide binding]; other site 278137009695 putative cAMP binding site [chemical binding]; other site 278137009696 Transposase domain (DUF772); Region: DUF772; pfam05598 278137009697 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137009698 DDE superfamily endonuclease; Region: DDE_4; cl15789 278137009699 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 278137009700 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 278137009701 Helix-turn-helix domains; Region: HTH; cl00088 278137009702 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 278137009703 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137009704 AMP-binding enzyme; Region: AMP-binding; cl15778 278137009705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 278137009706 Transposase; Region: DDE_Tnp_ISL3; pfam01610 278137009707 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137009708 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137009709 active site 278137009710 Carboxylesterase family; Region: COesterase; pfam00135 278137009711 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137009712 substrate binding pocket [chemical binding]; other site 278137009713 catalytic triad [active] 278137009714 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278137009715 active site 278137009716 metal binding site [ion binding]; metal-binding site 278137009717 Uncharacterized conserved protein [Function unknown]; Region: COG5361 278137009718 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 278137009719 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 278137009720 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137009721 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 278137009722 Helix-turn-helix domains; Region: HTH; cl00088 278137009723 HTH-like domain; Region: HTH_21; pfam13276 278137009724 Integrase core domain; Region: rve; cl01316 278137009725 Integrase core domain; Region: rve_3; cl15866 278137009726 putative transposase OrfB; Reviewed; Region: PHA02517 278137009727 Integrase core domain; Region: rve; cl01316 278137009728 Integrase core domain; Region: rve_3; cl15866 278137009729 HTH-like domain; Region: HTH_21; pfam13276 278137009730 Integrase core domain; Region: rve; cl01316 278137009731 Integrase core domain; Region: rve_3; cl15866 278137009732 Helix-turn-helix domains; Region: HTH; cl00088 278137009733 Helix-turn-helix domains; Region: HTH; cl00088 278137009734 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137009735 MULE transposase domain; Region: MULE; pfam10551 278137009736 Protein of unknown function DUF45; Region: DUF45; cl00636 278137009737 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 278137009738 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 278137009739 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137009740 ATP binding site [chemical binding]; other site 278137009741 putative Mg++ binding site [ion binding]; other site 278137009742 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 278137009743 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 278137009744 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 278137009745 HsdM N-terminal domain; Region: HsdM_N; pfam12161 278137009746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137009747 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137009748 MULE transposase domain; Region: MULE; pfam10551 278137009749 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 278137009750 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 278137009751 GIY-YIG motif/motif A; other site 278137009752 putative active site [active] 278137009753 putative metal binding site [ion binding]; other site 278137009754 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 278137009755 AAA-like domain; Region: AAA_10; pfam12846 278137009756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009757 Walker B motif; other site 278137009758 Replication-relaxation; Region: Replic_Relax; pfam13814 278137009759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137009760 Antirestriction protein (ArdA); Region: ArdA; cl01953 278137009761 Helix-turn-helix domains; Region: HTH; cl00088 278137009762 HTH-like domain; Region: HTH_21; pfam13276 278137009763 Integrase core domain; Region: rve; cl01316 278137009764 Integrase core domain; Region: rve_3; cl15866 278137009765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137009766 non-specific DNA binding site [nucleotide binding]; other site 278137009767 salt bridge; other site 278137009768 sequence-specific DNA binding site [nucleotide binding]; other site 278137009769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137009770 putative substrate translocation pore; other site 278137009771 phosphoglucomutase; Validated; Region: PRK07564 278137009772 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 278137009773 active site 278137009774 substrate binding site [chemical binding]; other site 278137009775 metal binding site [ion binding]; metal-binding site 278137009776 CrcB-like protein; Region: CRCB; cl09114 278137009777 CrcB-like protein; Region: CRCB; cl09114 278137009778 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 278137009779 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 278137009780 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137009781 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 278137009782 AMP-binding enzyme; Region: AMP-binding; cl15778 278137009783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 278137009784 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 278137009785 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137009786 MULE transposase domain; Region: MULE; pfam10551 278137009787 Integrase core domain; Region: rve; cl01316 278137009788 Integrase core domain; Region: rve_3; cl15866 278137009789 Protein of unknown function (DUF808); Region: DUF808; cl01002 278137009790 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 278137009791 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137009792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137009793 motif II; other site 278137009794 Transport protein; Region: actII; TIGR00833 278137009795 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 278137009796 NMT1-like family; Region: NMT1_2; cl15260 278137009797 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 278137009798 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 278137009799 nucleotide binding site [chemical binding]; other site 278137009800 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137009801 anti sigma factor interaction site; other site 278137009802 regulatory phosphorylation site [posttranslational modification]; other site 278137009803 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 278137009804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137009805 dimer interface [polypeptide binding]; other site 278137009806 phosphorylation site [posttranslational modification] 278137009807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137009808 ATP binding site [chemical binding]; other site 278137009809 Mg2+ binding site [ion binding]; other site 278137009810 G-X-G motif; other site 278137009811 Response regulator receiver domain; Region: Response_reg; pfam00072 278137009812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137009813 active site 278137009814 phosphorylation site [posttranslational modification] 278137009815 intermolecular recognition site; other site 278137009816 dimerization interface [polypeptide binding]; other site 278137009817 PAS domain S-box; Region: sensory_box; TIGR00229 278137009818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 278137009819 putative active site [active] 278137009820 heme pocket [chemical binding]; other site 278137009821 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 278137009822 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 278137009823 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 278137009824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137009825 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137009826 anti sigma factor interaction site; other site 278137009827 regulatory phosphorylation site [posttranslational modification]; other site 278137009828 PAS fold; Region: PAS_3; pfam08447 278137009829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 278137009830 putative active site [active] 278137009831 heme pocket [chemical binding]; other site 278137009832 ANTAR domain; Region: ANTAR; cl04297 278137009833 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137009834 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 278137009835 Spore germination protein; Region: Spore_permease; cl15802 278137009836 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 278137009837 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137009838 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 278137009839 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137009840 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137009841 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137009842 Cutinase; Region: Cutinase; pfam01083 278137009843 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 278137009844 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 278137009845 dimer interface [polypeptide binding]; other site 278137009846 PYR/PP interface [polypeptide binding]; other site 278137009847 TPP binding site [chemical binding]; other site 278137009848 substrate binding site [chemical binding]; other site 278137009849 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 278137009850 TPP-binding site [chemical binding]; other site 278137009851 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 278137009852 Helix-turn-helix domains; Region: HTH; cl00088 278137009853 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 278137009854 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 278137009855 active site 278137009856 Cutinase; Region: Cutinase; pfam01083 278137009857 Protein of unknown function (DUF998); Region: DUF998; pfam06197 278137009858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009859 NAD(P) binding site [chemical binding]; other site 278137009860 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 278137009861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009862 active site 278137009863 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 278137009864 LabA_like proteins; Region: LabA_like; cd06167 278137009865 putative metal binding site [ion binding]; other site 278137009866 Uncharacterized conserved protein [Function unknown]; Region: COG1432 278137009867 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 278137009868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137009869 metal binding site [ion binding]; metal-binding site 278137009870 active site 278137009871 I-site; other site 278137009872 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137009873 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 278137009874 SmpB-tmRNA interface; other site 278137009875 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 278137009876 FtsX-like permease family; Region: FtsX; cl15850 278137009877 FtsX-like permease family; Region: FtsX; cl15850 278137009878 Type II (General) Secretory Pathway (IISP) Family protein; Region: 3a0501s02; TIGR00960 278137009879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009880 Walker A/P-loop; other site 278137009881 ATP binding site [chemical binding]; other site 278137009882 Q-loop/lid; other site 278137009883 ABC transporter signature motif; other site 278137009884 Walker B; other site 278137009885 D-loop; other site 278137009886 H-loop/switch region; other site 278137009887 Mechanosensitive ion channel; Region: MS_channel; pfam00924 278137009888 peptide chain release factor 2; Validated; Region: prfB; PRK00578 278137009889 RF-1 domain; Region: RF-1; cl02875 278137009890 RF-1 domain; Region: RF-1; cl02875 278137009891 ferredoxin-NADP+ reductase; Region: PLN02852 278137009892 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 278137009893 active site 278137009894 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137009895 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137009896 active site 278137009897 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137009898 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137009899 active site 278137009900 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 278137009901 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137009902 molybdopterin cofactor binding site; other site 278137009903 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 278137009904 putative molybdopterin cofactor binding site; other site 278137009905 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 278137009906 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 278137009907 NADP binding site [chemical binding]; other site 278137009908 dimer interface [polypeptide binding]; other site 278137009909 Predicted esterase [General function prediction only]; Region: COG0627 278137009910 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137009911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137009912 Helix-turn-helix domains; Region: HTH; cl00088 278137009913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137009914 active site 278137009915 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137009916 Cupin domain; Region: Cupin_2; cl09118 278137009917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137009918 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 278137009919 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137009920 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137009921 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 278137009922 active site 278137009923 catalytic residues [active] 278137009924 metal binding site [ion binding]; metal-binding site 278137009925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137009926 Helix-turn-helix domains; Region: HTH; cl00088 278137009927 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137009928 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137009929 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 278137009930 active site 278137009931 Phosphotransferase enzyme family; Region: APH; pfam01636 278137009932 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 278137009933 putative active site [active] 278137009934 putative substrate binding site [chemical binding]; other site 278137009935 ATP binding site [chemical binding]; other site 278137009936 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 278137009937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137009938 S-adenosylmethionine binding site [chemical binding]; other site 278137009939 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137009940 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137009941 Predicted ATPase [General function prediction only]; Region: COG3899 278137009942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137009943 DNA binding residues [nucleotide binding] 278137009944 dimerization interface [polypeptide binding]; other site 278137009945 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 278137009946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137009947 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 278137009948 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 278137009949 triacylglycerol lipase; Region: PLN02872 278137009950 Predicted ATPase [General function prediction only]; Region: COG3899 278137009951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137009952 DNA binding residues [nucleotide binding] 278137009953 dimerization interface [polypeptide binding]; other site 278137009954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137009955 active site 278137009956 phosphorylation site [posttranslational modification] 278137009957 intermolecular recognition site; other site 278137009958 dimerization interface [polypeptide binding]; other site 278137009959 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 278137009960 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 278137009961 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 278137009962 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 278137009963 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 278137009964 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 278137009965 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 278137009966 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 278137009967 putative dimer interface [polypeptide binding]; other site 278137009968 [2Fe-2S] cluster binding site [ion binding]; other site 278137009969 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 278137009970 SLBB domain; Region: SLBB; pfam10531 278137009971 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 278137009972 NADH dehydrogenase subunit G; Validated; Region: PRK07860 278137009973 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 278137009974 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 278137009975 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 278137009976 molybdopterin cofactor binding site; other site 278137009977 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 278137009978 NADH dehydrogenase; Region: NADHdh; cl00469 278137009979 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 278137009980 4Fe-4S binding domain; Region: Fer4; cl02805 278137009981 4Fe-4S binding domain; Region: Fer4; cl02805 278137009982 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 278137009983 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 278137009984 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 278137009985 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 278137009986 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 278137009987 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 278137009988 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 278137009989 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 278137009990 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 278137009991 enoyl-CoA hydratase; Provisional; Region: PRK06190 278137009992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137009993 substrate binding site [chemical binding]; other site 278137009994 oxyanion hole (OAH) forming residues; other site 278137009995 trimer interface [polypeptide binding]; other site 278137009996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137009997 Helix-turn-helix domains; Region: HTH; cl00088 278137009998 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 278137009999 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 278137010000 putative active site [active] 278137010001 putative substrate binding site [chemical binding]; other site 278137010002 ATP binding site [chemical binding]; other site 278137010003 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137010004 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137010005 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 278137010006 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 278137010007 NAD(P) binding site [chemical binding]; other site 278137010008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137010009 Predicted ATPase [General function prediction only]; Region: COG3899 278137010010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137010011 DNA binding residues [nucleotide binding] 278137010012 dimerization interface [polypeptide binding]; other site 278137010013 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 278137010014 homotetramer interface [polypeptide binding]; other site 278137010015 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137010016 NAD binding site [chemical binding]; other site 278137010017 homodimer interface [polypeptide binding]; other site 278137010018 active site 278137010019 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137010020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137010021 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137010022 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137010023 classical (c) SDRs; Region: SDR_c; cd05233 278137010024 NAD(P) binding site [chemical binding]; other site 278137010025 active site 278137010026 Isochorismatase family; Region: Isochorismatase; pfam00857 278137010027 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 278137010028 catalytic triad [active] 278137010029 conserved cis-peptide bond; other site 278137010030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137010031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137010032 active site 278137010033 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 278137010034 NAD(P) binding site [chemical binding]; other site 278137010035 catalytic residues [active] 278137010036 GAF domain; Region: GAF_2; pfam13185 278137010037 GAF domain; Region: GAF; cl15785 278137010038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137010039 metal binding site [ion binding]; metal-binding site 278137010040 active site 278137010041 I-site; other site 278137010042 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 278137010043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010044 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 278137010045 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137010046 NAD(P) binding site [chemical binding]; other site 278137010047 PE-PPE domain; Region: PE-PPE; pfam08237 278137010048 PAS fold; Region: PAS_2; pfam08446 278137010049 GAF domain; Region: GAF; cl15785 278137010050 Phytochrome region; Region: PHY; pfam00360 278137010051 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 278137010052 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 278137010053 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137010054 anti sigma factor interaction site; other site 278137010055 regulatory phosphorylation site [posttranslational modification]; other site 278137010056 GAF domain; Region: GAF; cl15785 278137010057 GAF domain; Region: GAF; cl15785 278137010058 GAF domain; Region: GAF_2; pfam13185 278137010059 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 278137010060 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 278137010061 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 278137010062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137010063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137010064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137010065 membrane-bound complex binding site; other site 278137010066 hinge residues; other site 278137010067 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137010068 metabolite-proton symporter; Region: 2A0106; TIGR00883 278137010069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137010070 putative substrate translocation pore; other site 278137010071 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 278137010072 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137010073 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 278137010074 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 278137010075 lipid-transfer protein; Provisional; Region: PRK06059 278137010076 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 278137010077 active site 278137010078 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137010079 mce related protein; Region: MCE; pfam02470 278137010080 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137010081 mce related protein; Region: MCE; pfam02470 278137010082 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137010083 mce related protein; Region: MCE; pfam02470 278137010084 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137010085 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137010086 mce related protein; Region: MCE; pfam02470 278137010087 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 278137010088 mce related protein; Region: MCE; pfam02470 278137010089 mce related protein; Region: MCE; pfam02470 278137010090 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 278137010091 Permease; Region: Permease; cl00510 278137010092 Permease; Region: Permease; cl00510 278137010093 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137010094 classical (c) SDRs; Region: SDR_c; cd05233 278137010095 NAD(P) binding site [chemical binding]; other site 278137010096 active site 278137010097 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137010098 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137010099 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 278137010100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010101 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 278137010102 NAD(P) binding site [chemical binding]; other site 278137010103 active site 278137010104 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137010105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010107 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137010108 catalytic loop [active] 278137010109 iron binding site [ion binding]; other site 278137010110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137010111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137010112 active site 278137010113 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 278137010114 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 278137010115 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 278137010116 active site 278137010117 Fe binding site [ion binding]; other site 278137010118 hypothetical protein; Validated; Region: PRK07121 278137010119 Transcriptional regulator [Transcription]; Region: IclR; COG1414 278137010120 Helix-turn-helix domains; Region: HTH; cl00088 278137010121 Bacterial transcriptional regulator; Region: IclR; pfam01614 278137010122 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137010123 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137010124 substrate binding pocket [chemical binding]; other site 278137010125 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137010126 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 278137010127 active site 278137010128 FMN binding site [chemical binding]; other site 278137010129 substrate binding site [chemical binding]; other site 278137010130 putative catalytic residue [active] 278137010131 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 278137010132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010133 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 278137010134 NAD(P) binding site [chemical binding]; other site 278137010135 active site 278137010136 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137010137 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137010138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137010139 active site 278137010140 acyl-CoA synthetase; Validated; Region: PRK08316 278137010141 AMP-binding enzyme; Region: AMP-binding; cl15778 278137010142 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137010143 classical (c) SDRs; Region: SDR_c; cd05233 278137010144 NAD(P) binding site [chemical binding]; other site 278137010145 active site 278137010146 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137010147 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137010148 hypothetical protein; Validated; Region: PRK07121 278137010149 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 278137010150 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 278137010151 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 278137010152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010153 Helix-turn-helix domains; Region: HTH; cl00088 278137010154 Flavin Reductases; Region: FlaRed; cl00801 278137010155 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 278137010156 CoenzymeA binding site [chemical binding]; other site 278137010157 subunit interaction site [polypeptide binding]; other site 278137010158 PHB binding site; other site 278137010159 GAF domain; Region: GAF_2; pfam13185 278137010160 GAF domain; Region: GAF; cl15785 278137010161 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137010162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137010163 Helix-turn-helix domains; Region: HTH; cl00088 278137010164 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 278137010165 Subunit I/III interface [polypeptide binding]; other site 278137010166 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137010167 catalytic core [active] 278137010168 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 278137010169 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 278137010170 ligand binding site [chemical binding]; other site 278137010171 heat shock protein 90; Provisional; Region: PRK05218 278137010172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137010173 FAD binding domain; Region: FAD_binding_4; pfam01565 278137010174 Helix-turn-helix domains; Region: HTH; cl00088 278137010175 DNA binding site [nucleotide binding] 278137010176 Bacterial transcriptional activator domain; Region: BTAD; smart01043 278137010177 Predicted ATPase [General function prediction only]; Region: COG3899 278137010178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137010179 Walker A motif; other site 278137010180 ATP binding site [chemical binding]; other site 278137010181 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 278137010182 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 278137010183 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 278137010184 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 278137010185 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 278137010186 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 278137010187 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 278137010188 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 278137010189 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137010190 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 278137010191 active site 278137010192 ATP binding site [chemical binding]; other site 278137010193 Transcription factor WhiB; Region: Whib; pfam02467 278137010194 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 278137010195 Family description; Region: UvrD_C_2; cl15862 278137010196 HRDC domain; Region: HRDC; cl02578 278137010197 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 278137010198 catalytic residues [active] 278137010199 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 278137010200 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 278137010201 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 278137010202 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 278137010203 putative NADH binding site [chemical binding]; other site 278137010204 putative active site [active] 278137010205 nudix motif; other site 278137010206 putative metal binding site [ion binding]; other site 278137010207 Ion channel; Region: Ion_trans_2; cl11596 278137010208 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 278137010209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010210 Predicted membrane protein [Function unknown]; Region: COG4270 278137010211 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 278137010212 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137010213 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 278137010214 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 278137010215 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 278137010216 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 278137010217 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 278137010218 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137010219 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 278137010220 active site 278137010221 DNA binding site [nucleotide binding] 278137010222 TIGR02569 family protein; Region: TIGR02569_actnb 278137010223 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 278137010224 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 278137010225 ATP binding site [chemical binding]; other site 278137010226 substrate interface [chemical binding]; other site 278137010227 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278137010228 active site residue [active] 278137010229 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 278137010230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137010231 Helix-turn-helix domains; Region: HTH; cl00088 278137010232 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 278137010233 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 278137010234 dinuclear metal binding motif [ion binding]; other site 278137010235 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 278137010236 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278137010237 ATP binding site [chemical binding]; other site 278137010238 Mg++ binding site [ion binding]; other site 278137010239 motif III; other site 278137010240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137010241 nucleotide binding region [chemical binding]; other site 278137010242 ATP-binding site [chemical binding]; other site 278137010243 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 278137010244 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 278137010245 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137010246 P-loop; other site 278137010247 Magnesium ion binding site [ion binding]; other site 278137010248 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137010249 Magnesium ion binding site [ion binding]; other site 278137010250 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137010251 catalytic core [active] 278137010252 isochorismate synthase DhbC; Validated; Region: PRK06923 278137010253 chorismate binding enzyme; Region: Chorismate_bind; cl10555 278137010254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137010255 Coenzyme A binding pocket [chemical binding]; other site 278137010256 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 278137010257 active site 278137010258 trimer interface [polypeptide binding]; other site 278137010259 dimer interface [polypeptide binding]; other site 278137010260 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 278137010261 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 278137010262 Transcription factor WhiB; Region: Whib; pfam02467 278137010263 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 278137010264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 278137010265 Histidine kinase; Region: HisKA_2; cl06527 278137010266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137010267 ATP binding site [chemical binding]; other site 278137010268 Mg2+ binding site [ion binding]; other site 278137010269 G-X-G motif; other site 278137010270 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278137010271 carboxyltransferase (CT) interaction site; other site 278137010272 biotinylation site [posttranslational modification]; other site 278137010273 Putative zinc-finger; Region: zf-HC2; cl15806 278137010274 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 278137010275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137010276 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137010277 DNA binding residues [nucleotide binding] 278137010278 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 278137010279 putative deacylase active site [active] 278137010280 short chain dehydrogenase; Provisional; Region: PRK08278 278137010281 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 278137010282 NAD(P) binding site [chemical binding]; other site 278137010283 homodimer interface [polypeptide binding]; other site 278137010284 active site 278137010285 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 278137010286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137010287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137010288 S-adenosylmethionine binding site [chemical binding]; other site 278137010289 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 278137010290 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 278137010291 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 278137010292 hinge; other site 278137010293 active site 278137010294 Predicted GTPases [General function prediction only]; Region: COG1162 278137010295 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 278137010296 GTPase/Zn-binding domain interface [polypeptide binding]; other site 278137010297 GTP/Mg2+ binding site [chemical binding]; other site 278137010298 G4 box; other site 278137010299 G5 box; other site 278137010300 G1 box; other site 278137010301 Switch I region; other site 278137010302 G2 box; other site 278137010303 G3 box; other site 278137010304 Switch II region; other site 278137010305 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278137010306 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278137010307 active site 278137010308 catalytic tetrad [active] 278137010309 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 278137010310 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 278137010311 putative di-iron ligands [ion binding]; other site 278137010312 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 278137010313 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 278137010314 FAD binding pocket [chemical binding]; other site 278137010315 FAD binding motif [chemical binding]; other site 278137010316 phosphate binding motif [ion binding]; other site 278137010317 beta-alpha-beta structure motif; other site 278137010318 NAD binding pocket [chemical binding]; other site 278137010319 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137010320 catalytic loop [active] 278137010321 iron binding site [ion binding]; other site 278137010322 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 278137010323 BCCT family transporter; Region: BCCT; cl00569 278137010324 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 278137010325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137010326 ATP binding site [chemical binding]; other site 278137010327 putative Mg++ binding site [ion binding]; other site 278137010328 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 278137010329 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 278137010330 30S subunit binding site; other site 278137010331 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 278137010332 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 278137010333 iron-sulfur cluster [ion binding]; other site 278137010334 [2Fe-2S] cluster binding site [ion binding]; other site 278137010335 lipoprotein LpqB; Provisional; Region: PRK13616 278137010336 Sporulation and spore germination; Region: Germane; cl11253 278137010337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278137010338 dimerization interface [polypeptide binding]; other site 278137010339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137010340 dimer interface [polypeptide binding]; other site 278137010341 phosphorylation site [posttranslational modification] 278137010342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137010343 ATP binding site [chemical binding]; other site 278137010344 Mg2+ binding site [ion binding]; other site 278137010345 G-X-G motif; other site 278137010346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137010347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137010348 active site 278137010349 phosphorylation site [posttranslational modification] 278137010350 intermolecular recognition site; other site 278137010351 dimerization interface [polypeptide binding]; other site 278137010352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137010353 DNA binding site [nucleotide binding] 278137010354 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 278137010355 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 278137010356 TMP-binding site; other site 278137010357 ATP-binding site [chemical binding]; other site 278137010358 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278137010359 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 278137010360 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 278137010361 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 278137010362 oligomerization interface [polypeptide binding]; other site 278137010363 active site 278137010364 NAD+ binding site [chemical binding]; other site 278137010365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137010366 Helix-turn-helix domains; Region: HTH; cl00088 278137010367 Rubredoxin [Energy production and conversion]; Region: COG1773 278137010368 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 278137010369 iron binding site [ion binding]; other site 278137010370 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 278137010371 Rubredoxin; Region: Rubredoxin; pfam00301 278137010372 iron binding site [ion binding]; other site 278137010373 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 278137010374 Di-iron ligands [ion binding]; other site 278137010375 amino acid transporter; Region: 2A0306; TIGR00909 278137010376 Spore germination protein; Region: Spore_permease; cl15802 278137010377 Spore germination protein; Region: Spore_permease; cl15802 278137010378 Spore germination protein; Region: Spore_permease; cl15802 278137010379 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 278137010380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010381 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 278137010382 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 278137010383 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 278137010384 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 278137010385 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 278137010386 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 278137010387 active site 278137010388 substrate binding site [chemical binding]; other site 278137010389 metal binding site [ion binding]; metal-binding site 278137010390 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 278137010391 Transcription factor WhiB; Region: Whib; pfam02467 278137010392 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 278137010393 dimer interface [polypeptide binding]; other site 278137010394 phosphate binding site [ion binding]; other site 278137010395 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 278137010396 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 278137010397 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 278137010398 putative FMN binding site [chemical binding]; other site 278137010399 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 278137010400 nudix motif; other site 278137010401 PAS domain S-box; Region: sensory_box; TIGR00229 278137010402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137010403 metal binding site [ion binding]; metal-binding site 278137010404 active site 278137010405 I-site; other site 278137010406 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 278137010407 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 278137010408 active site 278137010409 Substrate binding site; other site 278137010410 Mg++ binding site; other site 278137010411 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 278137010412 putative CoA binding site [chemical binding]; other site 278137010413 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 278137010414 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 278137010415 Probable Catalytic site; other site 278137010416 metal-binding site 278137010417 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 278137010418 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 278137010419 NADP binding site [chemical binding]; other site 278137010420 active site 278137010421 putative substrate binding site [chemical binding]; other site 278137010422 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 278137010423 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 278137010424 AMP-binding enzyme; Region: AMP-binding; cl15778 278137010425 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 278137010426 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 278137010427 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 278137010428 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137010429 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 278137010430 FAD binding site [chemical binding]; other site 278137010431 homotetramer interface [polypeptide binding]; other site 278137010432 substrate binding pocket [chemical binding]; other site 278137010433 catalytic base [active] 278137010434 GAF domain; Region: GAF; cl15785 278137010435 AIR carboxylase; Region: AIRC; cl00310 278137010436 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 278137010437 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137010438 GtrA-like protein; Region: GtrA; cl00971 278137010439 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 278137010440 putative active site [active] 278137010441 Bacterial PH domain; Region: DUF304; cl01348 278137010442 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 278137010443 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 278137010444 hypothetical protein; Provisional; Region: PRK07208 278137010445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010446 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 278137010447 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 278137010448 catalytic residue [active] 278137010449 putative FPP diphosphate binding site; other site 278137010450 putative FPP binding hydrophobic cleft; other site 278137010451 dimer interface [polypeptide binding]; other site 278137010452 putative IPP diphosphate binding site; other site 278137010453 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 278137010454 Bacterial sugar transferase; Region: Bac_transf; cl00939 278137010455 Low molecular weight phosphatase family; Region: LMWPc; cd00115 278137010456 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 278137010457 active site 278137010458 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 278137010459 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 278137010460 substrate binding site; other site 278137010461 tetramer interface; other site 278137010462 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 278137010463 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 278137010464 NAD binding site [chemical binding]; other site 278137010465 substrate binding site [chemical binding]; other site 278137010466 homodimer interface [polypeptide binding]; other site 278137010467 active site 278137010468 Cupin domain; Region: Cupin_2; cl09118 278137010469 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 278137010470 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 278137010471 NADP binding site [chemical binding]; other site 278137010472 active site 278137010473 putative substrate binding site [chemical binding]; other site 278137010474 Helix-turn-helix domains; Region: HTH; cl00088 278137010475 putative transposase OrfB; Reviewed; Region: PHA02517 278137010476 HTH-like domain; Region: HTH_21; pfam13276 278137010477 Integrase core domain; Region: rve; cl01316 278137010478 Integrase core domain; Region: rve_3; cl15866 278137010479 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137010480 putative transposase OrfB; Reviewed; Region: PHA02517 278137010481 Integrase core domain; Region: rve; cl01316 278137010482 Integrase core domain; Region: rve_3; cl15866 278137010483 Helix-turn-helix domains; Region: HTH; cl00088 278137010484 HTH-like domain; Region: HTH_21; pfam13276 278137010485 Integrase core domain; Region: rve; cl01316 278137010486 Helix-turn-helix domains; Region: HTH; cl00088 278137010487 Helix-turn-helix domains; Region: HTH; cl00088 278137010488 Winged helix-turn helix; Region: HTH_29; pfam13551 278137010489 Helix-turn-helix domains; Region: HTH; cl00088 278137010490 Integrase core domain; Region: rve; cl01316 278137010491 Integrase core domain; Region: rve_3; cl15866 278137010492 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 278137010493 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 278137010494 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 278137010495 Helix-turn-helix domains; Region: HTH; cl00088 278137010496 putative transposase OrfB; Reviewed; Region: PHA02517 278137010497 HTH-like domain; Region: HTH_21; pfam13276 278137010498 Integrase core domain; Region: rve; cl01316 278137010499 Integrase core domain; Region: rve_3; cl15866 278137010500 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137010501 putative transposase OrfB; Reviewed; Region: PHA02517 278137010502 HTH-like domain; Region: HTH_21; pfam13276 278137010503 Integrase core domain; Region: rve; cl01316 278137010504 Integrase core domain; Region: rve_3; cl15866 278137010505 Helix-turn-helix domains; Region: HTH; cl00088 278137010506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137010507 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137010508 active site 278137010509 Int/Topo IB signature motif; other site 278137010510 DNA binding site [nucleotide binding] 278137010511 putative transposase OrfB; Reviewed; Region: PHA02517 278137010512 HTH-like domain; Region: HTH_21; pfam13276 278137010513 Integrase core domain; Region: rve; cl01316 278137010514 Integrase core domain; Region: rve_3; cl15866 278137010515 Helix-turn-helix domains; Region: HTH; cl00088 278137010516 Helix-turn-helix domains; Region: HTH; cl00088 278137010517 putative transposase OrfB; Reviewed; Region: PHA02517 278137010518 HTH-like domain; Region: HTH_21; pfam13276 278137010519 Integrase core domain; Region: rve; cl01316 278137010520 Integrase core domain; Region: rve_3; cl15866 278137010521 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 278137010522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137010523 S-adenosylmethionine binding site [chemical binding]; other site 278137010524 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 278137010525 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137010526 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137010527 MULE transposase domain; Region: MULE; pfam10551 278137010528 Helix-turn-helix domains; Region: HTH; cl00088 278137010529 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137010530 putative transposase OrfB; Reviewed; Region: PHA02517 278137010531 HTH-like domain; Region: HTH_21; pfam13276 278137010532 Integrase core domain; Region: rve; cl01316 278137010533 Integrase core domain; Region: rve_3; cl15866 278137010534 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137010535 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 278137010536 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 278137010537 putative ADP-binding pocket [chemical binding]; other site 278137010538 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 278137010539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137010540 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 278137010541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010542 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 278137010543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010544 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 278137010545 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 278137010546 Probable Catalytic site; other site 278137010547 metal-binding site 278137010548 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278137010549 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 278137010550 active site 278137010551 catalytic residues [active] 278137010552 DNA binding site [nucleotide binding] 278137010553 Int/Topo IB signature motif; other site 278137010554 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137010555 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278137010556 active site 278137010557 DNA binding site [nucleotide binding] 278137010558 Int/Topo IB signature motif; other site 278137010559 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137010560 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137010561 MULE transposase domain; Region: MULE; pfam10551 278137010562 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 278137010563 MatE; Region: MatE; cl10513 278137010564 MatE; Region: MatE; cl10513 278137010565 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 278137010566 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137010567 O-Antigen ligase; Region: Wzy_C; cl04850 278137010568 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137010569 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137010570 MULE transposase domain; Region: MULE; pfam10551 278137010571 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137010572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137010573 Helix-turn-helix domains; Region: HTH; cl00088 278137010574 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137010575 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278137010576 active site 278137010577 DNA binding site [nucleotide binding] 278137010578 Int/Topo IB signature motif; other site 278137010579 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278137010580 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 278137010581 active site 278137010582 catalytic residues [active] 278137010583 DNA binding site [nucleotide binding] 278137010584 Int/Topo IB signature motif; other site 278137010585 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137010586 MULE transposase domain; Region: MULE; pfam10551 278137010587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137010588 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 278137010589 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278137010590 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 278137010591 active site 278137010592 catalytic residues [active] 278137010593 DNA binding site [nucleotide binding] 278137010594 Int/Topo IB signature motif; other site 278137010595 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137010596 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278137010597 active site 278137010598 DNA binding site [nucleotide binding] 278137010599 Int/Topo IB signature motif; other site 278137010600 putative transposase OrfB; Reviewed; Region: PHA02517 278137010601 HTH-like domain; Region: HTH_21; pfam13276 278137010602 Integrase core domain; Region: rve; cl01316 278137010603 Integrase core domain; Region: rve_3; cl15866 278137010604 Helix-turn-helix domains; Region: HTH; cl00088 278137010605 Chain length determinant protein; Region: Wzz; cl15801 278137010606 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 278137010607 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 278137010608 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 278137010609 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137010610 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137010611 Maf-like protein; Region: Maf; pfam02545 278137010612 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 278137010613 putative active site [active] 278137010614 OpgC protein; Region: OpgC_C; cl00792 278137010615 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 278137010616 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 278137010617 active site residue [active] 278137010618 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 278137010619 active site residue [active] 278137010620 Fe-S metabolism associated domain; Region: SufE; cl00951 278137010621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137010622 metal binding site [ion binding]; metal-binding site 278137010623 active site 278137010624 I-site; other site 278137010625 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 278137010626 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278137010627 ATP-grasp domain; Region: ATP-grasp_4; cl03087 278137010628 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 278137010629 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278137010630 carboxyltransferase (CT) interaction site; other site 278137010631 biotinylation site [posttranslational modification]; other site 278137010632 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 278137010633 Ligand binding site; other site 278137010634 metal-binding site 278137010635 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137010636 anti sigma factor interaction site; other site 278137010637 regulatory phosphorylation site [posttranslational modification]; other site 278137010638 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 278137010639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137010640 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 278137010641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137010642 DNA binding residues [nucleotide binding] 278137010643 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 278137010644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137010645 CsbD-like; Region: CsbD; cl15799 278137010646 Restriction endonuclease; Region: Mrr_cat; cl00516 278137010647 L-lysine aminotransferase; Provisional; Region: PRK08297 278137010648 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137010649 inhibitor-cofactor binding pocket; inhibition site 278137010650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137010651 catalytic residue [active] 278137010652 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 278137010653 Helix-turn-helix domains; Region: HTH; cl00088 278137010654 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 278137010655 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 278137010656 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137010657 tetrameric interface [polypeptide binding]; other site 278137010658 NAD binding site [chemical binding]; other site 278137010659 catalytic residues [active] 278137010660 classical (c) SDRs; Region: SDR_c; cd05233 278137010661 short chain dehydrogenase; Provisional; Region: PRK05650 278137010662 NAD(P) binding site [chemical binding]; other site 278137010663 active site 278137010664 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137010665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137010666 Helix-turn-helix domains; Region: HTH; cl00088 278137010667 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 278137010668 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 278137010669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137010670 DNA binding residues [nucleotide binding] 278137010671 dimerization interface [polypeptide binding]; other site 278137010672 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 278137010673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137010674 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 278137010675 ATP binding site [chemical binding]; other site 278137010676 putative Mg++ binding site [ion binding]; other site 278137010677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137010678 nucleotide binding region [chemical binding]; other site 278137010679 ATP-binding site [chemical binding]; other site 278137010680 DEAD/H associated; Region: DEAD_assoc; pfam08494 278137010681 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 278137010682 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 278137010683 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 278137010684 putative DNA binding site [nucleotide binding]; other site 278137010685 catalytic residue [active] 278137010686 putative H2TH interface [polypeptide binding]; other site 278137010687 putative catalytic residues [active] 278137010688 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 278137010689 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 278137010690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137010691 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 278137010692 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 278137010693 putative di-iron ligands [ion binding]; other site 278137010694 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 278137010695 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 278137010696 FAD binding pocket [chemical binding]; other site 278137010697 FAD binding motif [chemical binding]; other site 278137010698 phosphate binding motif [ion binding]; other site 278137010699 beta-alpha-beta structure motif; other site 278137010700 NAD binding pocket [chemical binding]; other site 278137010701 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137010702 catalytic loop [active] 278137010703 iron binding site [ion binding]; other site 278137010704 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 278137010705 Helix-turn-helix domains; Region: HTH; cl00088 278137010706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137010707 substrate binding site [chemical binding]; other site 278137010708 oxyanion hole (OAH) forming residues; other site 278137010709 trimer interface [polypeptide binding]; other site 278137010710 short chain dehydrogenase; Provisional; Region: PRK06841 278137010711 classical (c) SDRs; Region: SDR_c; cd05233 278137010712 NAD(P) binding site [chemical binding]; other site 278137010713 active site 278137010714 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 278137010715 active site 278137010716 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 278137010717 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 278137010718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137010720 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278137010721 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 278137010722 putative active site pocket [active] 278137010723 dimerization interface [polypeptide binding]; other site 278137010724 putative catalytic residue [active] 278137010725 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 278137010726 Transport protein; Region: actII; TIGR00833 278137010727 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 278137010728 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 278137010729 metal binding site [ion binding]; metal-binding site 278137010730 putative dimer interface [polypeptide binding]; other site 278137010731 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 278137010732 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 278137010733 metal binding site [ion binding]; metal-binding site 278137010734 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 278137010735 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 278137010736 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 278137010737 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 278137010738 Helix-turn-helix domains; Region: HTH; cl00088 278137010739 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 278137010740 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 278137010741 active site 278137010742 substrate binding site [chemical binding]; other site 278137010743 metal binding site [ion binding]; metal-binding site 278137010744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278137010745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137010746 Coenzyme A binding pocket [chemical binding]; other site 278137010747 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 278137010748 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137010749 inhibitor-cofactor binding pocket; inhibition site 278137010750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137010751 catalytic residue [active] 278137010752 Cupin domain; Region: Cupin_2; cl09118 278137010753 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 278137010754 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137010755 active site 278137010756 NlpC/P60 family; Region: NLPC_P60; cl11438 278137010757 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 278137010758 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137010759 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 278137010760 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278137010761 active site 278137010762 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 278137010763 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 278137010764 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 278137010765 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 278137010766 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 278137010767 active site 278137010768 catalytic motif [active] 278137010769 Zn binding site [ion binding]; other site 278137010770 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 278137010771 putative Iron-sulfur protein interface [polypeptide binding]; other site 278137010772 putative proximal heme binding site [chemical binding]; other site 278137010773 putative SdhD-like interface [polypeptide binding]; other site 278137010774 putative distal heme binding site [chemical binding]; other site 278137010775 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 278137010776 putative Iron-sulfur protein interface [polypeptide binding]; other site 278137010777 putative proximal heme binding site [chemical binding]; other site 278137010778 putative SdhC-like subunit interface [polypeptide binding]; other site 278137010779 putative distal heme binding site [chemical binding]; other site 278137010780 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 278137010781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010782 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 278137010783 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 278137010784 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 278137010785 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137010786 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 278137010787 CGNR zinc finger; Region: zf-CGNR; pfam11706 278137010788 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 278137010789 Uncharacterized conserved protein [Function unknown]; Region: COG2128 278137010790 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 278137010791 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137010792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137010793 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137010794 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 278137010795 putative transposase OrfB; Reviewed; Region: PHA02517 278137010796 HTH-like domain; Region: HTH_21; pfam13276 278137010797 Integrase core domain; Region: rve; cl01316 278137010798 Integrase core domain; Region: rve_3; cl15866 278137010799 Helix-turn-helix domains; Region: HTH; cl00088 278137010800 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 278137010801 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 278137010802 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 278137010803 Zn binding site [ion binding]; other site 278137010804 HTH-like domain; Region: HTH_21; pfam13276 278137010805 Integrase core domain; Region: rve; cl01316 278137010806 Integrase core domain; Region: rve_3; cl15866 278137010807 Helix-turn-helix domains; Region: HTH; cl00088 278137010808 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 278137010809 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137010810 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137010811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137010812 DNA binding residues [nucleotide binding] 278137010813 dimerization interface [polypeptide binding]; other site 278137010814 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 278137010815 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137010816 NAD(P) binding site [chemical binding]; other site 278137010817 catalytic residues [active] 278137010818 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 278137010819 Helix-turn-helix domains; Region: HTH; cl00088 278137010820 hypothetical protein; Provisional; Region: PRK06541 278137010821 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137010822 inhibitor-cofactor binding pocket; inhibition site 278137010823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137010824 catalytic residue [active] 278137010825 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 278137010826 Strictosidine synthase; Region: Str_synth; pfam03088 278137010827 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 278137010828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137010829 DNA binding residues [nucleotide binding] 278137010830 dimerization interface [polypeptide binding]; other site 278137010831 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 278137010832 AMP-binding enzyme; Region: AMP-binding; cl15778 278137010833 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137010834 AMP-binding domain protein; Validated; Region: PRK08315 278137010835 AMP-binding enzyme; Region: AMP-binding; cl15778 278137010836 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137010837 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 278137010838 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 278137010839 putative active site [active] 278137010840 putative metal binding site [ion binding]; other site 278137010841 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 278137010842 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137010843 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 278137010844 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 278137010845 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 278137010846 active site 278137010847 HIGH motif; other site 278137010848 dimer interface [polypeptide binding]; other site 278137010849 KMSKS motif; other site 278137010850 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 278137010851 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 278137010852 putative active site [active] 278137010853 putative catalytic site [active] 278137010854 putative DNA binding site [nucleotide binding]; other site 278137010855 putative phosphate binding site [ion binding]; other site 278137010856 metal binding site A [ion binding]; metal-binding site 278137010857 putative AP binding site [nucleotide binding]; other site 278137010858 putative metal binding site B [ion binding]; other site 278137010859 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137010860 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 278137010861 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 278137010862 homodimer interface [polypeptide binding]; other site 278137010863 substrate-cofactor binding pocket; other site 278137010864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137010865 catalytic residue [active] 278137010866 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137010867 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 278137010868 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 278137010869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137010870 S-adenosylmethionine binding site [chemical binding]; other site 278137010871 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 278137010872 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 278137010873 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 278137010874 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 278137010875 homodimer interface [polypeptide binding]; other site 278137010876 NADP binding site [chemical binding]; other site 278137010877 substrate binding site [chemical binding]; other site 278137010878 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 278137010879 active site 278137010880 FMN binding site [chemical binding]; other site 278137010881 substrate binding site [chemical binding]; other site 278137010882 putative catalytic residue [active] 278137010883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137010884 Helix-turn-helix domains; Region: HTH; cl00088 278137010885 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 278137010886 phosphopeptide binding site; other site 278137010887 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 278137010888 phosphopeptide binding site; other site 278137010889 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 278137010890 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278137010891 Walker A/P-loop; other site 278137010892 ATP binding site [chemical binding]; other site 278137010893 Q-loop/lid; other site 278137010894 ABC transporter signature motif; other site 278137010895 Walker B; other site 278137010896 D-loop; other site 278137010897 H-loop/switch region; other site 278137010898 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 278137010899 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137010900 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 278137010901 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 278137010902 heme-binding site [chemical binding]; other site 278137010903 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 278137010904 FAD binding pocket [chemical binding]; other site 278137010905 FAD binding motif [chemical binding]; other site 278137010906 phosphate binding motif [ion binding]; other site 278137010907 beta-alpha-beta structure motif; other site 278137010908 NAD binding pocket [chemical binding]; other site 278137010909 Heme binding pocket [chemical binding]; other site 278137010910 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 278137010911 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 278137010912 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 278137010913 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 278137010914 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 278137010915 G1 box; other site 278137010916 GTP/Mg2+ binding site [chemical binding]; other site 278137010917 G2 box; other site 278137010918 Switch I region; other site 278137010919 G3 box; other site 278137010920 Switch II region; other site 278137010921 G4 box; other site 278137010922 G5 box; other site 278137010923 Protein of unknown function (DUF742); Region: DUF742; pfam05331 278137010924 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 278137010925 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 278137010926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137010927 ATP binding site [chemical binding]; other site 278137010928 Mg2+ binding site [ion binding]; other site 278137010929 G-X-G motif; other site 278137010930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137010931 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 278137010932 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 278137010933 putative FMN binding site [chemical binding]; other site 278137010934 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 278137010935 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 278137010936 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 278137010937 generic binding surface II; other site 278137010938 generic binding surface I; other site 278137010939 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 278137010940 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137010941 metal binding site [ion binding]; metal-binding site 278137010942 active site 278137010943 I-site; other site 278137010944 enoyl-CoA hydratase; Region: PLN02864 278137010945 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278137010946 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 278137010947 dimer interaction site [polypeptide binding]; other site 278137010948 substrate-binding tunnel; other site 278137010949 active site 278137010950 catalytic site [active] 278137010951 substrate binding site [chemical binding]; other site 278137010952 short chain dehydrogenase; Provisional; Region: PRK07201 278137010953 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 278137010954 putative NAD(P) binding site [chemical binding]; other site 278137010955 active site 278137010956 putative substrate binding site [chemical binding]; other site 278137010957 classical (c) SDRs; Region: SDR_c; cd05233 278137010958 NAD(P) binding site [chemical binding]; other site 278137010959 active site 278137010960 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 278137010961 active site 278137010962 DNA Polymerase Y-family; Region: PolY_like; cd03468 278137010963 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 278137010964 DNA binding site [nucleotide binding] 278137010965 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 278137010966 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278137010967 DNA binding residues [nucleotide binding] 278137010968 putative dimer interface [polypeptide binding]; other site 278137010969 GMP synthase; Reviewed; Region: guaA; PRK00074 278137010970 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 278137010971 AMP/PPi binding site [chemical binding]; other site 278137010972 candidate oxyanion hole; other site 278137010973 catalytic triad [active] 278137010974 potential glutamine specificity residues [chemical binding]; other site 278137010975 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 278137010976 ATP Binding subdomain [chemical binding]; other site 278137010977 Ligand Binding sites [chemical binding]; other site 278137010978 Dimerization subdomain; other site 278137010979 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 278137010980 Helix-turn-helix domains; Region: HTH; cl00088 278137010981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 278137010982 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 278137010983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137010984 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 278137010985 Helix-turn-helix domains; Region: HTH; cl00088 278137010986 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 278137010987 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137010988 phosphate binding site [ion binding]; other site 278137010989 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 278137010990 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137010991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 278137010992 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 278137010993 active site 278137010994 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 278137010995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137010996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137010997 DNA binding residues [nucleotide binding] 278137010998 Transcription factor WhiB; Region: Whib; pfam02467 278137010999 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 278137011000 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 278137011001 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 278137011002 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 278137011003 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 278137011004 NeuB family; Region: NeuB; cl00496 278137011005 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 278137011006 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 278137011007 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 278137011008 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 278137011009 ring oligomerisation interface [polypeptide binding]; other site 278137011010 ATP/Mg binding site [chemical binding]; other site 278137011011 stacking interactions; other site 278137011012 hinge regions; other site 278137011013 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 278137011014 oligomerisation interface [polypeptide binding]; other site 278137011015 mobile loop; other site 278137011016 roof hairpin; other site 278137011017 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137011018 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137011019 active site 278137011020 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137011021 UGMP family protein; Validated; Region: PRK09604 278137011022 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 278137011023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278137011024 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137011025 Coenzyme A binding pocket [chemical binding]; other site 278137011026 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 278137011027 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 278137011028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137011029 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137011030 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137011031 alanine racemase; Reviewed; Region: alr; PRK00053 278137011032 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 278137011033 active site 278137011034 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 278137011035 dimer interface [polypeptide binding]; other site 278137011036 substrate binding site [chemical binding]; other site 278137011037 catalytic residues [active] 278137011038 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 278137011039 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137011040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137011041 catalytic residue [active] 278137011042 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 278137011043 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 278137011044 putative substrate binding site [chemical binding]; other site 278137011045 putative ATP binding site [chemical binding]; other site 278137011046 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137011047 anti sigma factor interaction site; other site 278137011048 regulatory phosphorylation site [posttranslational modification]; other site 278137011049 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 278137011050 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 278137011051 glutaminase active site [active] 278137011052 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 278137011053 dimer interface [polypeptide binding]; other site 278137011054 active site 278137011055 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 278137011056 dimer interface [polypeptide binding]; other site 278137011057 active site 278137011058 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 278137011059 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137011060 Helix-turn-helix domains; Region: HTH; cl00088 278137011061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137011062 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011063 active site 278137011064 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 278137011065 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 278137011066 active site 278137011067 substrate binding site [chemical binding]; other site 278137011068 metal binding site [ion binding]; metal-binding site 278137011069 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 278137011070 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 278137011071 23S rRNA interface [nucleotide binding]; other site 278137011072 L3 interface [polypeptide binding]; other site 278137011073 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 278137011074 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 278137011075 NAD binding site [chemical binding]; other site 278137011076 substrate binding site [chemical binding]; other site 278137011077 catalytic Zn binding site [ion binding]; other site 278137011078 tetramer interface [polypeptide binding]; other site 278137011079 structural Zn binding site [ion binding]; other site 278137011080 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 278137011081 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137011082 NAD(P) binding site [chemical binding]; other site 278137011083 catalytic residues [active] 278137011084 Helix-turn-helix domains; Region: HTH; cl00088 278137011085 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 278137011086 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 278137011087 Proteins of 100 residues with WXG; Region: WXG100; cl02005 278137011088 Proteins of 100 residues with WXG; Region: WXG100; cl02005 278137011089 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 278137011090 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 278137011091 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011092 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 278137011093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011094 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011095 Ubiquitin-like proteins; Region: UBQ; cl00155 278137011096 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 278137011097 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 278137011098 active site 278137011099 catalytic residues [active] 278137011100 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 278137011101 CGNR zinc finger; Region: zf-CGNR; pfam11706 278137011102 EamA-like transporter family; Region: EamA; cl01037 278137011103 EamA-like transporter family; Region: EamA; cl01037 278137011104 Cutinase; Region: Cutinase; pfam01083 278137011105 Cutinase; Region: Cutinase; pfam01083 278137011106 Cutinase; Region: Cutinase; pfam01083 278137011107 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 278137011108 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 278137011109 dimerization interface 3.5A [polypeptide binding]; other site 278137011110 active site 278137011111 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 278137011112 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 278137011113 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 278137011114 alphaNTD - beta interaction site [polypeptide binding]; other site 278137011115 alphaNTD homodimer interface [polypeptide binding]; other site 278137011116 alphaNTD - beta' interaction site [polypeptide binding]; other site 278137011117 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 278137011118 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 278137011119 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 278137011120 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278137011121 RNA binding surface [nucleotide binding]; other site 278137011122 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 278137011123 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 278137011124 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 278137011125 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 278137011126 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 278137011127 rRNA binding site [nucleotide binding]; other site 278137011128 predicted 30S ribosome binding site; other site 278137011129 high affinity sulphate transporter 1; Region: sulP; TIGR00815 278137011130 Sulfate transporter family; Region: Sulfate_transp; cl15842 278137011131 Sulfate transporter family; Region: Sulfate_transp; cl15842 278137011132 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 278137011133 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 278137011134 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137011135 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 278137011136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137011137 Ligand Binding Site [chemical binding]; other site 278137011138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137011139 Ligand Binding Site [chemical binding]; other site 278137011140 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 278137011141 Domain of unknown function DUF21; Region: DUF21; pfam01595 278137011142 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 278137011143 Transporter associated domain; Region: CorC_HlyC; cl08393 278137011144 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 278137011145 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 278137011146 AMP-binding enzyme; Region: AMP-binding; cl15778 278137011147 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137011148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137011149 Ligand Binding Site [chemical binding]; other site 278137011150 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137011151 Ligand Binding Site [chemical binding]; other site 278137011152 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 278137011153 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 278137011154 putative substrate binding site [chemical binding]; other site 278137011155 putative ATP binding site [chemical binding]; other site 278137011156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137011157 active site 278137011158 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 278137011159 Erythromycin esterase; Region: Erythro_esteras; pfam05139 278137011160 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 278137011161 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 278137011162 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137011163 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 278137011164 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 278137011165 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 278137011166 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 278137011167 phosphoenolpyruvate synthase; Validated; Region: PRK06464 278137011168 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 278137011169 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 278137011170 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 278137011171 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 278137011172 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137011173 Ligand Binding Site [chemical binding]; other site 278137011174 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 278137011175 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 278137011176 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137011177 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137011178 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 278137011179 hypothetical protein; Provisional; Region: PRK07877 278137011180 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 278137011181 dimer interface [polypeptide binding]; other site 278137011182 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 278137011183 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 278137011184 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 278137011185 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137011186 catalytic Zn binding site [ion binding]; other site 278137011187 structural Zn binding site [ion binding]; other site 278137011188 NAD(P) binding site [chemical binding]; other site 278137011189 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137011190 Ligand Binding Site [chemical binding]; other site 278137011191 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137011192 Ligand Binding Site [chemical binding]; other site 278137011193 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278137011194 Ligand Binding Site [chemical binding]; other site 278137011195 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 278137011196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137011197 active site 278137011198 phosphorylation site [posttranslational modification] 278137011199 intermolecular recognition site; other site 278137011200 dimerization interface [polypeptide binding]; other site 278137011201 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 278137011202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011204 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278137011205 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 278137011206 ligand binding site [chemical binding]; other site 278137011207 flexible hinge region; other site 278137011208 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 278137011209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137011210 ATP binding site [chemical binding]; other site 278137011211 Mg2+ binding site [ion binding]; other site 278137011212 G-X-G motif; other site 278137011213 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137011214 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 278137011215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137011216 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 278137011217 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 278137011218 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 278137011219 NAD binding site [chemical binding]; other site 278137011220 substrate binding site [chemical binding]; other site 278137011221 homodimer interface [polypeptide binding]; other site 278137011222 active site 278137011223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137011224 Helix-turn-helix domains; Region: HTH; cl00088 278137011225 hypothetical protein; Provisional; Region: PRK06184 278137011226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011227 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 278137011228 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 278137011229 tetrameric interface [polypeptide binding]; other site 278137011230 NAD binding site [chemical binding]; other site 278137011231 catalytic residues [active] 278137011232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137011233 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 278137011234 substrate binding pocket [chemical binding]; other site 278137011235 FAD binding site [chemical binding]; other site 278137011236 catalytic base [active] 278137011237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011238 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 278137011239 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 278137011240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137011241 motif II; other site 278137011242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 278137011243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137011244 active site 278137011245 phosphorylation site [posttranslational modification] 278137011246 intermolecular recognition site; other site 278137011247 dimerization interface [polypeptide binding]; other site 278137011248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137011249 DNA binding residues [nucleotide binding] 278137011250 dimerization interface [polypeptide binding]; other site 278137011251 GAF domain; Region: GAF; cl15785 278137011252 GAF domain; Region: GAF_2; pfam13185 278137011253 Histidine kinase; Region: HisKA_3; pfam07730 278137011254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137011255 ATP binding site [chemical binding]; other site 278137011256 Mg2+ binding site [ion binding]; other site 278137011257 G-X-G motif; other site 278137011258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137011259 Helix-turn-helix domains; Region: HTH; cl00088 278137011260 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 278137011261 Putative zinc-finger; Region: zf-HC2; cl15806 278137011262 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 278137011263 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137011264 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137011265 DNA binding residues [nucleotide binding] 278137011266 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 278137011267 active site 278137011268 adenylate kinase; Reviewed; Region: adk; PRK00279 278137011269 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 278137011270 AMP-binding site [chemical binding]; other site 278137011271 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 278137011272 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 278137011273 SecY translocase; Region: SecY; pfam00344 278137011274 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137011275 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137011276 Leucine carboxyl methyltransferase; Region: LCM; cl01306 278137011277 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 278137011278 tandem repeat interface [polypeptide binding]; other site 278137011279 oligomer interface [polypeptide binding]; other site 278137011280 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 278137011281 active site residues [active] 278137011282 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 278137011283 tandem repeat interface [polypeptide binding]; other site 278137011284 oligomer interface [polypeptide binding]; other site 278137011285 active site residues [active] 278137011286 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137011287 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 278137011288 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 278137011289 23S rRNA binding site [nucleotide binding]; other site 278137011290 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 278137011291 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 278137011292 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 278137011293 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 278137011294 5S rRNA interface [nucleotide binding]; other site 278137011295 L27 interface [polypeptide binding]; other site 278137011296 23S rRNA interface [nucleotide binding]; other site 278137011297 L5 interface [polypeptide binding]; other site 278137011298 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 278137011299 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 278137011300 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 278137011301 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 278137011302 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 278137011303 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 278137011304 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 278137011305 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 278137011306 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 278137011307 KOW motif; Region: KOW; cl00354 278137011308 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 278137011309 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 278137011310 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 278137011311 Sulfatase; Region: Sulfatase; cl10460 278137011312 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 278137011313 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 278137011314 putative translocon interaction site; other site 278137011315 23S rRNA interface [nucleotide binding]; other site 278137011316 signal recognition particle (SRP54) interaction site; other site 278137011317 L23 interface [polypeptide binding]; other site 278137011318 trigger factor interaction site; other site 278137011319 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 278137011320 23S rRNA interface [nucleotide binding]; other site 278137011321 5S rRNA interface [nucleotide binding]; other site 278137011322 putative antibiotic binding site [chemical binding]; other site 278137011323 L25 interface [polypeptide binding]; other site 278137011324 L27 interface [polypeptide binding]; other site 278137011325 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 278137011326 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 278137011327 G-X-X-G motif; other site 278137011328 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 278137011329 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 278137011330 putative translocon binding site; other site 278137011331 protein-rRNA interface [nucleotide binding]; other site 278137011332 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 278137011333 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 278137011334 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 278137011335 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 278137011336 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 278137011337 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 278137011338 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 278137011339 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 278137011340 Carboxylesterase family; Region: COesterase; pfam00135 278137011341 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137011342 substrate binding pocket [chemical binding]; other site 278137011343 catalytic triad [active] 278137011344 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137011345 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137011346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137011347 Helix-turn-helix domains; Region: HTH; cl00088 278137011348 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 278137011349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011350 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 278137011351 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 278137011352 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 278137011353 Probable Catalytic site; other site 278137011354 metal-binding site 278137011355 Creatinine amidohydrolase; Region: Creatininase; cl00618 278137011356 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 278137011357 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 278137011358 phosphate binding site [ion binding]; other site 278137011359 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 278137011360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278137011361 FeS/SAM binding site; other site 278137011362 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 278137011363 mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967 278137011364 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 278137011365 Helix-turn-helix domains; Region: HTH; cl00088 278137011366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137011367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137011368 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 278137011369 putative dimer interface [polypeptide binding]; other site 278137011370 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137011371 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 278137011372 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137011373 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278137011374 active site 278137011375 metal binding site [ion binding]; metal-binding site 278137011376 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137011377 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137011378 active site 278137011379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 278137011380 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137011381 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 278137011382 Helix-turn-helix domains; Region: HTH; cl00088 278137011383 AsnC family; Region: AsnC_trans_reg; pfam01037 278137011384 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 278137011385 Amidinotransferase; Region: Amidinotransf; cl12043 278137011386 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 278137011387 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137011388 inhibitor-cofactor binding pocket; inhibition site 278137011389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137011390 catalytic residue [active] 278137011391 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137011392 classical (c) SDRs; Region: SDR_c; cd05233 278137011393 NAD(P) binding site [chemical binding]; other site 278137011394 active site 278137011395 Short C-terminal domain; Region: SHOCT; cl01373 278137011396 Cutinase; Region: Cutinase; pfam01083 278137011397 elongation factor Tu; Reviewed; Region: PRK00049 278137011398 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 278137011399 G1 box; other site 278137011400 GEF interaction site [polypeptide binding]; other site 278137011401 GTP/Mg2+ binding site [chemical binding]; other site 278137011402 Switch I region; other site 278137011403 G2 box; other site 278137011404 G3 box; other site 278137011405 Switch II region; other site 278137011406 G4 box; other site 278137011407 G5 box; other site 278137011408 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 278137011409 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 278137011410 Antibiotic Binding Site [chemical binding]; other site 278137011411 elongation factor G; Reviewed; Region: PRK00007 278137011412 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 278137011413 G1 box; other site 278137011414 putative GEF interaction site [polypeptide binding]; other site 278137011415 GTP/Mg2+ binding site [chemical binding]; other site 278137011416 Switch I region; other site 278137011417 G2 box; other site 278137011418 G3 box; other site 278137011419 Switch II region; other site 278137011420 G4 box; other site 278137011421 G5 box; other site 278137011422 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 278137011423 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 278137011424 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 278137011425 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 278137011426 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 278137011427 S17 interaction site [polypeptide binding]; other site 278137011428 S8 interaction site; other site 278137011429 16S rRNA interaction site [nucleotide binding]; other site 278137011430 streptomycin interaction site [chemical binding]; other site 278137011431 23S rRNA interaction site [nucleotide binding]; other site 278137011432 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 278137011433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137011434 Helix-turn-helix domains; Region: HTH; cl00088 278137011435 WHG domain; Region: WHG; pfam13305 278137011436 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 278137011437 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 278137011438 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 278137011439 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 278137011440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137011441 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 278137011442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137011443 substrate binding site [chemical binding]; other site 278137011444 oxyanion hole (OAH) forming residues; other site 278137011445 trimer interface [polypeptide binding]; other site 278137011446 PaaX-like protein; Region: PaaX; pfam07848 278137011447 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 278137011448 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 278137011449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011450 active site 278137011451 Methyltransferase domain; Region: Methyltransf_31; pfam13847 278137011452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137011453 S-adenosylmethionine binding site [chemical binding]; other site 278137011454 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 278137011455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137011456 active site 278137011457 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 278137011458 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 278137011459 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 278137011460 putative active site [active] 278137011461 putative substrate binding site [chemical binding]; other site 278137011462 putative cosubstrate binding site; other site 278137011463 catalytic site [active] 278137011464 endonuclease IV; Provisional; Region: PRK01060 278137011465 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 278137011466 AP (apurinic/apyrimidinic) site pocket; other site 278137011467 DNA interaction; other site 278137011468 Metal-binding active site; metal-binding site 278137011469 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 278137011470 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 278137011471 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 278137011472 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 278137011473 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 278137011474 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 278137011475 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 278137011476 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 278137011477 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 278137011478 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 278137011479 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 278137011480 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 278137011481 G-loop; other site 278137011482 DNA binding site [nucleotide binding] 278137011483 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 278137011484 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 278137011485 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 278137011486 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 278137011487 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 278137011488 RPB10 interaction site [polypeptide binding]; other site 278137011489 RPB1 interaction site [polypeptide binding]; other site 278137011490 RPB11 interaction site [polypeptide binding]; other site 278137011491 RPB3 interaction site [polypeptide binding]; other site 278137011492 RPB12 interaction site [polypeptide binding]; other site 278137011493 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 278137011494 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 278137011495 Walker A/P-loop; other site 278137011496 ATP binding site [chemical binding]; other site 278137011497 Q-loop/lid; other site 278137011498 ABC transporter signature motif; other site 278137011499 Walker B; other site 278137011500 D-loop; other site 278137011501 H-loop/switch region; other site 278137011502 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 278137011503 core dimer interface [polypeptide binding]; other site 278137011504 peripheral dimer interface [polypeptide binding]; other site 278137011505 L10 interface [polypeptide binding]; other site 278137011506 L11 interface [polypeptide binding]; other site 278137011507 putative EF-Tu interaction site [polypeptide binding]; other site 278137011508 putative EF-G interaction site [polypeptide binding]; other site 278137011509 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 278137011510 23S rRNA interface [nucleotide binding]; other site 278137011511 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 278137011512 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 278137011513 active site 278137011514 catalytic site [active] 278137011515 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 278137011516 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 278137011517 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 278137011518 Predicted transcriptional regulator [Transcription]; Region: COG2378 278137011519 Helix-turn-helix domains; Region: HTH; cl00088 278137011520 WYL domain; Region: WYL; cl14852 278137011521 DinB superfamily; Region: DinB_2; pfam12867 278137011522 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137011523 DinB superfamily; Region: DinB_2; pfam12867 278137011524 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137011525 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137011526 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137011527 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 278137011528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137011529 S-adenosylmethionine binding site [chemical binding]; other site 278137011530 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 278137011531 mRNA/rRNA interface [nucleotide binding]; other site 278137011532 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 278137011533 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 278137011534 23S rRNA interface [nucleotide binding]; other site 278137011535 L7/L12 interface [polypeptide binding]; other site 278137011536 putative thiostrepton binding site; other site 278137011537 L25 interface [polypeptide binding]; other site 278137011538 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 278137011539 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 278137011540 putative homodimer interface [polypeptide binding]; other site 278137011541 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 278137011542 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 278137011543 active site 278137011544 catalytic site [active] 278137011545 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 278137011546 active site 278137011547 catalytic site [active] 278137011548 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 278137011549 active site 278137011550 catalytic site [active] 278137011551 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 278137011552 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137011553 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 278137011554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137011555 substrate binding site [chemical binding]; other site 278137011556 oxyanion hole (OAH) forming residues; other site 278137011557 trimer interface [polypeptide binding]; other site 278137011558 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 278137011559 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 278137011560 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 278137011561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137011562 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 278137011563 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 278137011564 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 278137011565 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 278137011566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011567 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 278137011568 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 278137011569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011570 Family description; Region: UvrD_C_2; cl15862 278137011571 bifunctional UGMP family protein/serine/threonine protein kinase; Validated; Region: PRK09605 278137011572 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 278137011573 Cupin domain; Region: Cupin_2; cl09118 278137011574 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 278137011575 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 278137011576 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 278137011577 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 278137011578 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137011579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011580 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 278137011581 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 278137011582 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137011583 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 278137011584 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137011585 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 278137011586 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 278137011587 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278137011588 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 278137011589 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 278137011590 malonyl-CoA binding site [chemical binding]; other site 278137011591 dimer interface [polypeptide binding]; other site 278137011592 active site 278137011593 product binding site; other site 278137011594 Phospholipid methyltransferase; Region: PEMT; cl00763 278137011595 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 278137011596 MASE1; Region: MASE1; pfam05231 278137011597 PAS domain S-box; Region: sensory_box; TIGR00229 278137011598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 278137011599 putative active site [active] 278137011600 heme pocket [chemical binding]; other site 278137011601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137011602 metal binding site [ion binding]; metal-binding site 278137011603 active site 278137011604 I-site; other site 278137011605 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 278137011606 homodimer interface [polypeptide binding]; other site 278137011607 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 278137011608 active site pocket [active] 278137011609 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 278137011610 Predicted esterase [General function prediction only]; Region: COG0627 278137011611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137011612 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 278137011613 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137011614 classical (c) SDRs; Region: SDR_c; cd05233 278137011615 NAD(P) binding site [chemical binding]; other site 278137011616 active site 278137011617 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011618 Domain of unknown function DUF87; Region: DUF87; pfam01935 278137011619 AAA-like domain; Region: AAA_10; pfam12846 278137011620 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011621 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278137011622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011623 PIF1-like helicase; Region: PIF1; pfam05970 278137011624 Family description; Region: UvrD_C_2; cl15862 278137011625 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 278137011626 catalytic site [active] 278137011627 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 278137011628 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137011629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137011630 catalytic residue [active] 278137011631 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 278137011632 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 278137011633 NAD(P) binding site [chemical binding]; other site 278137011634 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137011635 Nitronate monooxygenase; Region: NMO; pfam03060 278137011636 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137011637 FMN binding site [chemical binding]; other site 278137011638 substrate binding site [chemical binding]; other site 278137011639 putative catalytic residue [active] 278137011640 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 278137011641 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 278137011642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 278137011643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011644 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 278137011645 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 278137011646 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 278137011647 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 278137011648 putative [4Fe-4S] binding site [ion binding]; other site 278137011649 putative molybdopterin cofactor binding site [chemical binding]; other site 278137011650 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 278137011651 molybdopterin cofactor binding site; other site 278137011652 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 278137011653 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137011654 Transmembrane secretion effector; Region: MFS_3; pfam05977 278137011655 YceI-like domain; Region: YceI; cl01001 278137011656 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 278137011657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137011659 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011660 active site 278137011661 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137011662 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011663 Integral membrane protein TerC family; Region: TerC; cl10468 278137011664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137011665 Dehydratase family; Region: ILVD_EDD; cl00340 278137011666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137011667 Helix-turn-helix domains; Region: HTH; cl00088 278137011668 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 278137011669 Helix-turn-helix domains; Region: HTH; cl00088 278137011670 GAF domain; Region: GAF_2; pfam13185 278137011671 GAF domain; Region: GAF; cl15785 278137011672 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137011673 PAS domain S-box; Region: sensory_box; TIGR00229 278137011674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 278137011675 putative active site [active] 278137011676 heme pocket [chemical binding]; other site 278137011677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137011678 metal binding site [ion binding]; metal-binding site 278137011679 active site 278137011680 I-site; other site 278137011681 OsmC-like protein; Region: OsmC; cl00767 278137011682 Restriction endonuclease; Region: Mrr_cat; cl00516 278137011683 non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276 278137011684 RNA/DNA hybrid binding site [nucleotide binding]; other site 278137011685 active site 278137011686 PE-PPE domain; Region: PE-PPE; pfam08237 278137011687 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 278137011688 nudix motif; other site 278137011689 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 278137011690 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 278137011691 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 278137011692 active site 278137011693 metal binding site [ion binding]; metal-binding site 278137011694 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137011695 Helix-turn-helix domains; Region: HTH; cl00088 278137011696 HTH-like domain; Region: HTH_21; pfam13276 278137011697 Integrase core domain; Region: rve; cl01316 278137011698 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278137011699 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278137011700 active site 278137011701 DNA binding site [nucleotide binding] 278137011702 Int/Topo IB signature motif; other site 278137011703 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278137011704 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 278137011705 active site 278137011706 catalytic residues [active] 278137011707 DNA binding site [nucleotide binding] 278137011708 Int/Topo IB signature motif; other site 278137011709 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137011710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 278137011711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 278137011712 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 278137011713 VanW like protein; Region: VanW; pfam04294 278137011714 ERCC4 domain; Region: ERCC4; cl10594 278137011715 Lsr2; Region: Lsr2; pfam11774 278137011716 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 278137011717 putative active site [active] 278137011718 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 278137011719 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 278137011720 Predicted acyl esterases [General function prediction only]; Region: COG2936 278137011721 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137011722 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 278137011723 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 278137011724 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 278137011725 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 278137011726 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 278137011727 putative di-iron ligands [ion binding]; other site 278137011728 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 278137011729 hypothetical protein; Provisional; Region: PRK02250 278137011730 methionine aminopeptidase; Provisional; Region: PRK12318 278137011731 SEC-C motif; Region: SEC-C; pfam02810 278137011732 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 278137011733 putative active site [active] 278137011734 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 278137011735 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 278137011736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011737 Zeta toxin; Region: Zeta_toxin; pfam06414 278137011738 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 278137011739 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 278137011740 putative active site [active] 278137011741 homotetrameric interface [polypeptide binding]; other site 278137011742 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137011743 AAA domain; Region: AAA_23; pfam13476 278137011744 Walker A/P-loop; other site 278137011745 ATP binding site [chemical binding]; other site 278137011746 hypothetical protein; Validated; Region: PRK09039 278137011747 Uncharacterized conserved protein [Function unknown]; Region: COG4717 278137011748 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 278137011749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137011750 ATP binding site [chemical binding]; other site 278137011751 putative Mg++ binding site [ion binding]; other site 278137011752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137011753 nucleotide binding region [chemical binding]; other site 278137011754 ATP-binding site [chemical binding]; other site 278137011755 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 278137011756 putative catalytic site [active] 278137011757 putative phosphate binding site [ion binding]; other site 278137011758 putative metal binding site [ion binding]; other site 278137011759 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 278137011760 metal ion-dependent adhesion site (MIDAS); other site 278137011761 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137011762 MULE transposase domain; Region: MULE; pfam10551 278137011763 putative transposase OrfB; Reviewed; Region: PHA02517 278137011764 Integrase core domain; Region: rve; cl01316 278137011765 Integrase core domain; Region: rve_3; cl15866 278137011766 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 278137011767 putative transposase OrfB; Reviewed; Region: PHA02517 278137011768 HTH-like domain; Region: HTH_21; pfam13276 278137011769 Integrase core domain; Region: rve; cl01316 278137011770 Integrase core domain; Region: rve_3; cl15866 278137011771 Helix-turn-helix domains; Region: HTH; cl00088 278137011772 Helix-turn-helix domains; Region: HTH; cl00088 278137011773 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 278137011774 putative transposase OrfB; Reviewed; Region: PHA02517 278137011775 HTH-like domain; Region: HTH_21; pfam13276 278137011776 Integrase core domain; Region: rve; cl01316 278137011777 Integrase core domain; Region: rve_3; cl15866 278137011778 Restriction endonuclease; Region: Mrr_cat; cl00516 278137011779 Transposase, Mutator family; Region: Transposase_mut; pfam00872 278137011780 MULE transposase domain; Region: MULE; pfam10551 278137011781 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 278137011782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137011783 cofactor binding site; other site 278137011784 DNA binding site [nucleotide binding] 278137011785 substrate interaction site [chemical binding]; other site 278137011786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137011787 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 278137011788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137011789 ATP binding site [chemical binding]; other site 278137011790 putative Mg++ binding site [ion binding]; other site 278137011791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137011792 nucleotide binding region [chemical binding]; other site 278137011793 ATP-binding site [chemical binding]; other site 278137011794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137011795 ATP binding site [chemical binding]; other site 278137011796 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137011797 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 278137011798 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 278137011799 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 278137011800 putative ADP-binding pocket [chemical binding]; other site 278137011801 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137011802 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137011803 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137011804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137011805 O-Antigen ligase; Region: Wzy_C; cl04850 278137011806 MatE; Region: MatE; cl10513 278137011807 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278137011808 GAF domain; Region: GAF; cl15785 278137011809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011810 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 278137011811 NAD(P) binding site [chemical binding]; other site 278137011812 active site 278137011813 short chain dehydrogenase; Provisional; Region: PRK07856 278137011814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011815 NAD(P) binding site [chemical binding]; other site 278137011816 active site 278137011817 enoyl-CoA hydratase; Provisional; Region: PRK06495 278137011818 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137011819 substrate binding site [chemical binding]; other site 278137011820 oxyanion hole (OAH) forming residues; other site 278137011821 trimer interface [polypeptide binding]; other site 278137011822 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137011823 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137011824 Nitronate monooxygenase; Region: NMO; pfam03060 278137011825 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137011826 FMN binding site [chemical binding]; other site 278137011827 substrate binding site [chemical binding]; other site 278137011828 putative catalytic residue [active] 278137011829 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 278137011830 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 278137011831 NAD binding site [chemical binding]; other site 278137011832 catalytic Zn binding site [ion binding]; other site 278137011833 substrate binding site [chemical binding]; other site 278137011834 structural Zn binding site [ion binding]; other site 278137011835 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 278137011836 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 278137011837 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 278137011838 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137011839 dimer interface [polypeptide binding]; other site 278137011840 active site 278137011841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137011842 Helix-turn-helix domains; Region: HTH; cl00088 278137011843 short chain dehydrogenase; Provisional; Region: PRK07831 278137011844 classical (c) SDRs; Region: SDR_c; cd05233 278137011845 NAD(P) binding site [chemical binding]; other site 278137011846 active site 278137011847 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 278137011848 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 278137011849 FAD binding site [chemical binding]; other site 278137011850 substrate binding site [chemical binding]; other site 278137011851 catalytic base [active] 278137011852 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 278137011853 AMP-binding enzyme; Region: AMP-binding; cl15778 278137011854 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137011855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137011856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011857 active site 278137011858 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 278137011859 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 278137011860 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011861 active site 278137011862 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 278137011863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011864 aspartate aminotransferase; Provisional; Region: PRK05764 278137011865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278137011866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137011867 homodimer interface [polypeptide binding]; other site 278137011868 catalytic residue [active] 278137011869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137011870 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137011871 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 278137011872 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 278137011873 AMP-binding enzyme; Region: AMP-binding; cl15778 278137011874 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 278137011875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137011876 NAD(P) binding site [chemical binding]; other site 278137011877 active site 278137011878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137011879 metabolite-proton symporter; Region: 2A0106; TIGR00883 278137011880 putative substrate translocation pore; other site 278137011881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278137011882 Helix-turn-helix domains; Region: HTH; cl00088 278137011883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137011884 dimerization interface [polypeptide binding]; other site 278137011885 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 278137011886 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137011887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137011888 Helix-turn-helix domains; Region: HTH; cl00088 278137011889 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 278137011890 Flavin Reductases; Region: FlaRed; cl00801 278137011891 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 278137011892 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 278137011893 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 278137011894 active site 278137011895 Fe binding site [ion binding]; other site 278137011896 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 278137011897 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137011898 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137011899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137011900 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 278137011901 Flavin binding site [chemical binding]; other site 278137011902 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 278137011903 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 278137011904 FAD binding pocket [chemical binding]; other site 278137011905 FAD binding motif [chemical binding]; other site 278137011906 phosphate binding motif [ion binding]; other site 278137011907 beta-alpha-beta structure motif; other site 278137011908 NAD(p) ribose binding residues [chemical binding]; other site 278137011909 NAD binding pocket [chemical binding]; other site 278137011910 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 278137011911 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137011912 catalytic loop [active] 278137011913 iron binding site [ion binding]; other site 278137011914 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 278137011915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011916 active site 278137011917 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137011918 active site 278137011919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137011920 Helix-turn-helix domains; Region: HTH; cl00088 278137011921 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137011922 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 278137011923 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278137011924 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278137011925 DNA binding site [nucleotide binding] 278137011926 domain linker motif; other site 278137011927 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 278137011928 putative dimerization interface [polypeptide binding]; other site 278137011929 putative ligand binding site [chemical binding]; other site 278137011930 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 278137011931 ABC-ATPase subunit interface; other site 278137011932 dimer interface [polypeptide binding]; other site 278137011933 putative PBP binding regions; other site 278137011934 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 278137011935 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 278137011936 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 278137011937 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 278137011938 intersubunit interface [polypeptide binding]; other site 278137011939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137011940 metal binding site [ion binding]; metal-binding site 278137011941 active site 278137011942 I-site; other site 278137011943 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 278137011944 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 278137011945 active site residue [active] 278137011946 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 278137011947 active site residue [active] 278137011948 LamB/YcsF family; Region: LamB_YcsF; cl00664 278137011949 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137011950 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 278137011951 transmembrane helices; other site 278137011952 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 278137011953 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 278137011954 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 278137011955 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 278137011956 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278137011957 active site 278137011958 HIGH motif; other site 278137011959 nucleotide binding site [chemical binding]; other site 278137011960 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 278137011961 KMSKS motif; other site 278137011962 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 278137011963 homotrimer interaction site [polypeptide binding]; other site 278137011964 zinc binding site [ion binding]; other site 278137011965 CDP-binding sites; other site 278137011966 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 278137011967 DNA repair protein RadA; Provisional; Region: PRK11823 278137011968 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 278137011969 Walker A motif/ATP binding site; other site 278137011970 ATP binding site [chemical binding]; other site 278137011971 Walker B motif; other site 278137011972 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 278137011973 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 278137011974 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 278137011975 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 278137011976 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 278137011977 active site clefts [active] 278137011978 zinc binding site [ion binding]; other site 278137011979 dimer interface [polypeptide binding]; other site 278137011980 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 278137011981 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 278137011982 minor groove reading motif; other site 278137011983 helix-hairpin-helix signature motif; other site 278137011984 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 278137011985 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 278137011986 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 278137011987 conserved cys residue [active] 278137011988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137011989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137011990 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137011991 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 278137011992 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 278137011993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137011994 Transposase [DNA replication, recombination, and repair]; Region: COG5421 278137011995 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 278137011996 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137011997 catalytic core [active] 278137011998 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 278137011999 Clp protease ATP binding subunit; Region: clpC; CHL00095 278137012000 Clp amino terminal domain; Region: Clp_N; pfam02861 278137012001 Clp amino terminal domain; Region: Clp_N; pfam02861 278137012002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137012003 Walker A motif; other site 278137012004 ATP binding site [chemical binding]; other site 278137012005 Walker B motif; other site 278137012006 arginine finger; other site 278137012007 UvrB/uvrC motif; Region: UVR; pfam02151 278137012008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137012009 Walker A motif; other site 278137012010 ATP binding site [chemical binding]; other site 278137012011 Walker B motif; other site 278137012012 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 278137012013 Lsr2; Region: Lsr2; pfam11774 278137012014 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 278137012015 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 278137012016 dimer interface [polypeptide binding]; other site 278137012017 putative anticodon binding site; other site 278137012018 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 278137012019 motif 1; other site 278137012020 dimer interface [polypeptide binding]; other site 278137012021 active site 278137012022 motif 2; other site 278137012023 motif 3; other site 278137012024 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 278137012025 active site 278137012026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 278137012027 dimer interface [polypeptide binding]; other site 278137012028 substrate binding site [chemical binding]; other site 278137012029 catalytic residue [active] 278137012030 Type III pantothenate kinase; Region: Pan_kinase; cl09130 278137012031 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 278137012032 tetramerization interface [polypeptide binding]; other site 278137012033 active site 278137012034 Pantoate-beta-alanine ligase; Region: PanC; cd00560 278137012035 active site 278137012036 ATP-binding site [chemical binding]; other site 278137012037 pantoate-binding site; other site 278137012038 HXXH motif; other site 278137012039 Uncharacterized conserved protein [Function unknown]; Region: COG5495 278137012040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012041 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 278137012042 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 278137012043 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 278137012044 catalytic center binding site [active] 278137012045 ATP binding site [chemical binding]; other site 278137012046 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 278137012047 homooctamer interface [polypeptide binding]; other site 278137012048 active site 278137012049 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 278137012050 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 278137012051 substrate binding pocket [chemical binding]; other site 278137012052 dimer interface [polypeptide binding]; other site 278137012053 inhibitor binding site; inhibition site 278137012054 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 278137012055 homodecamer interface [polypeptide binding]; other site 278137012056 GTP cyclohydrolase I; Provisional; Region: PLN03044 278137012057 active site 278137012058 putative catalytic site residues [active] 278137012059 zinc binding site [ion binding]; other site 278137012060 GTP-CH-I/GFRP interaction surface; other site 278137012061 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 278137012062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137012063 Walker A motif; other site 278137012064 ATP binding site [chemical binding]; other site 278137012065 Walker B motif; other site 278137012066 arginine finger; other site 278137012067 Peptidase family M41; Region: Peptidase_M41; pfam01434 278137012068 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137012069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137012070 Protein of unknown function (DUF541); Region: SIMPL; cl01077 278137012071 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 278137012072 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 278137012073 putative [Fe4-S4] binding site [ion binding]; other site 278137012074 putative molybdopterin cofactor binding site [chemical binding]; other site 278137012075 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 278137012076 molybdopterin cofactor binding site; other site 278137012077 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137012078 active site 278137012079 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 278137012080 Ligand Binding Site [chemical binding]; other site 278137012081 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 278137012082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137012083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137012084 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 278137012085 dimer interface [polypeptide binding]; other site 278137012086 substrate binding site [chemical binding]; other site 278137012087 metal binding sites [ion binding]; metal-binding site 278137012088 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 278137012089 Integral membrane protein TerC family; Region: TerC; cl10468 278137012090 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 278137012091 AMP-binding enzyme; Region: AMP-binding; cl15778 278137012092 peptide synthase; Validated; Region: PRK05691 278137012093 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137012094 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 278137012095 putative trimer interface [polypeptide binding]; other site 278137012096 putative CoA binding site [chemical binding]; other site 278137012097 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 278137012098 putative trimer interface [polypeptide binding]; other site 278137012099 putative CoA binding site [chemical binding]; other site 278137012100 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 278137012101 Zn binding site [ion binding]; other site 278137012102 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 278137012103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012104 NAD(P) binding site [chemical binding]; other site 278137012105 active site 278137012106 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 278137012107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 278137012108 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137012109 DNA polymerase III subunit delta'; Validated; Region: PRK07940 278137012110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137012111 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 278137012112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 278137012113 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 278137012114 cyclase homology domain; Region: CHD; cd07302 278137012115 nucleotidyl binding site; other site 278137012116 metal binding site [ion binding]; metal-binding site 278137012117 dimer interface [polypeptide binding]; other site 278137012118 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 278137012119 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 278137012120 active site 278137012121 interdomain interaction site; other site 278137012122 putative metal-binding site [ion binding]; other site 278137012123 nucleotide binding site [chemical binding]; other site 278137012124 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 278137012125 domain I; other site 278137012126 phosphate binding site [ion binding]; other site 278137012127 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 278137012128 domain II; other site 278137012129 domain III; other site 278137012130 nucleotide binding site [chemical binding]; other site 278137012131 DNA binding groove [nucleotide binding] 278137012132 catalytic site [active] 278137012133 domain IV; other site 278137012134 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 278137012135 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 278137012136 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 278137012137 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 278137012138 DNA-binding site [nucleotide binding]; DNA binding site 278137012139 RNA-binding motif; other site 278137012140 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 278137012141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137012142 ATP binding site [chemical binding]; other site 278137012143 putative Mg++ binding site [ion binding]; other site 278137012144 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 278137012145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137012146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137012147 active site 278137012148 ATP binding site [chemical binding]; other site 278137012149 substrate binding site [chemical binding]; other site 278137012150 activation loop (A-loop); other site 278137012151 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137012152 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 278137012153 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 278137012154 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 278137012155 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 278137012156 ATP binding site [chemical binding]; other site 278137012157 Walker A motif; other site 278137012158 hexamer interface [polypeptide binding]; other site 278137012159 Walker B motif; other site 278137012160 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 278137012161 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 278137012162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137012163 motif II; other site 278137012164 acetyl-CoA synthetase; Provisional; Region: PRK00174 278137012165 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 278137012166 AMP-binding enzyme; Region: AMP-binding; cl15778 278137012167 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137012168 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 278137012169 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137012170 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 278137012171 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 278137012172 putative active site [active] 278137012173 putative CoA binding site [chemical binding]; other site 278137012174 nudix motif; other site 278137012175 metal binding site [ion binding]; metal-binding site 278137012176 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 278137012177 catalytic residues [active] 278137012178 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 278137012179 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 278137012180 minor groove reading motif; other site 278137012181 helix-hairpin-helix signature motif; other site 278137012182 substrate binding pocket [chemical binding]; other site 278137012183 active site 278137012184 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 278137012185 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278137012186 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 278137012187 ligand binding site [chemical binding]; other site 278137012188 flexible hinge region; other site 278137012189 Helix-turn-helix domains; Region: HTH; cl00088 278137012190 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 278137012191 Helix-turn-helix domains; Region: HTH; cl00088 278137012192 Winged helix-turn helix; Region: HTH_29; pfam13551 278137012193 Helix-turn-helix domains; Region: HTH; cl00088 278137012194 Integrase core domain; Region: rve; cl01316 278137012195 Integrase core domain; Region: rve_3; cl15866 278137012196 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 278137012197 Helix-turn-helix domains; Region: HTH; cl00088 278137012198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137012199 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 278137012200 homotrimer interaction site [polypeptide binding]; other site 278137012201 putative active site [active] 278137012202 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 278137012203 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 278137012204 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 278137012205 P loop; other site 278137012206 Nucleotide binding site [chemical binding]; other site 278137012207 DTAP/Switch II; other site 278137012208 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 278137012209 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 278137012210 DTAP/Switch II; other site 278137012211 Switch I; other site 278137012212 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 278137012213 Transcription factor WhiB; Region: Whib; pfam02467 278137012214 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 278137012215 Transglycosylase; Region: Transgly; cl07896 278137012216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137012217 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278137012218 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 278137012219 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 278137012220 putative active site [active] 278137012221 putative metal binding site [ion binding]; other site 278137012222 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 278137012223 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 278137012224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137012225 catalytic residue [active] 278137012226 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137012227 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 278137012228 Muconolactone delta-isomerase; Region: MIase; cl01992 278137012229 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 278137012230 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 278137012231 active site 278137012232 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 278137012233 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 278137012234 active site 278137012235 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 278137012236 Helix-turn-helix domains; Region: HTH; cl00088 278137012237 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 278137012238 dimerization interface [polypeptide binding]; other site 278137012239 substrate binding pocket [chemical binding]; other site 278137012240 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 278137012241 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137012242 iron-sulfur cluster [ion binding]; other site 278137012243 [2Fe-2S] cluster binding site [ion binding]; other site 278137012244 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 278137012245 putative alpha subunit interface [polypeptide binding]; other site 278137012246 putative active site [active] 278137012247 putative substrate binding site [chemical binding]; other site 278137012248 Fe binding site [ion binding]; other site 278137012249 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 278137012250 inter-subunit interface; other site 278137012251 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 278137012252 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 278137012253 catalytic loop [active] 278137012254 iron binding site [ion binding]; other site 278137012255 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 278137012256 FAD binding pocket [chemical binding]; other site 278137012257 FAD binding motif [chemical binding]; other site 278137012258 phosphate binding motif [ion binding]; other site 278137012259 beta-alpha-beta structure motif; other site 278137012260 NAD binding pocket [chemical binding]; other site 278137012261 FCD domain; Region: FCD; cl11656 278137012262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012263 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137012264 NAD(P) binding site [chemical binding]; other site 278137012265 active site 278137012266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137012267 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 278137012268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137012269 DNA binding residues [nucleotide binding] 278137012270 dimerization interface [polypeptide binding]; other site 278137012271 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137012272 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137012273 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 278137012274 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137012275 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137012276 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 278137012277 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 278137012278 dimer interface [polypeptide binding]; other site 278137012279 active site 278137012280 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 278137012281 Helix-turn-helix domains; Region: HTH; cl00088 278137012282 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 278137012283 dimerization interface [polypeptide binding]; other site 278137012284 substrate binding pocket [chemical binding]; other site 278137012285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137012286 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 278137012287 active site 278137012288 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 278137012289 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137012290 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 278137012291 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 278137012292 MoxR-like ATPases [General function prediction only]; Region: COG0714 278137012293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137012294 Walker A motif; other site 278137012295 ATP binding site [chemical binding]; other site 278137012296 Walker B motif; other site 278137012297 arginine finger; other site 278137012298 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 278137012299 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 278137012300 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 278137012301 Integral membrane protein DUF95; Region: DUF95; cl00572 278137012302 RDD family; Region: RDD; cl00746 278137012303 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 278137012304 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 278137012305 Helix-turn-helix domains; Region: HTH; cl00088 278137012306 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 278137012307 Helix-turn-helix domains; Region: HTH; cl00088 278137012308 putative DNA binding helix; other site 278137012309 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 278137012310 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278137012311 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278137012312 active site 278137012313 catalytic tetrad [active] 278137012314 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 278137012315 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 278137012316 G1 box; other site 278137012317 putative GEF interaction site [polypeptide binding]; other site 278137012318 GTP/Mg2+ binding site [chemical binding]; other site 278137012319 Switch I region; other site 278137012320 G2 box; other site 278137012321 G3 box; other site 278137012322 Switch II region; other site 278137012323 G4 box; other site 278137012324 G5 box; other site 278137012325 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 278137012326 glycerol kinase; Provisional; Region: glpK; PRK00047 278137012327 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 278137012328 N- and C-terminal domain interface [polypeptide binding]; other site 278137012329 active site 278137012330 MgATP binding site [chemical binding]; other site 278137012331 catalytic site [active] 278137012332 metal binding site [ion binding]; metal-binding site 278137012333 carbohydrate binding site [chemical binding]; other site 278137012334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137012335 S-adenosylmethionine binding site [chemical binding]; other site 278137012336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137012337 S-adenosylmethionine binding site [chemical binding]; other site 278137012338 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 278137012339 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 278137012340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137012341 Helix-turn-helix domains; Region: HTH; cl00088 278137012342 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137012343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137012344 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 278137012345 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 278137012346 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137012347 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137012348 catalytic residue [active] 278137012349 probable methyltransferase; Region: TIGR03438 278137012350 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 278137012351 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 278137012352 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 278137012353 putative active site [active] 278137012354 putative dimer interface [polypeptide binding]; other site 278137012355 TIGR03440 family protein; Region: unchr_TIGR03440 278137012356 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 278137012357 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 278137012358 PknH-like extracellular domain; Region: PknH_C; pfam14032 278137012359 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 278137012360 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 278137012361 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 278137012362 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 278137012363 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 278137012364 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 278137012365 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 278137012366 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 278137012367 tetramer interface [polypeptide binding]; other site 278137012368 heme binding pocket [chemical binding]; other site 278137012369 NADPH binding site [chemical binding]; other site 278137012370 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 278137012371 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 278137012372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012373 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 278137012374 aspartate kinase; Reviewed; Region: PRK06635 278137012375 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 278137012376 putative nucleotide binding site [chemical binding]; other site 278137012377 putative catalytic residues [active] 278137012378 putative Mg ion binding site [ion binding]; other site 278137012379 putative aspartate binding site [chemical binding]; other site 278137012380 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 278137012381 putative allosteric regulatory site; other site 278137012382 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 278137012383 putative allosteric regulatory residue; other site 278137012384 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 278137012385 putative FMN binding site [chemical binding]; other site 278137012386 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 278137012387 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 278137012388 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 278137012389 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 278137012390 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 278137012391 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 278137012392 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 278137012393 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 278137012394 active site 278137012395 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 278137012396 domain_subunit interface; other site 278137012397 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 278137012398 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 278137012399 active site 278137012400 FMN binding site [chemical binding]; other site 278137012401 substrate binding site [chemical binding]; other site 278137012402 3Fe-4S cluster binding site [ion binding]; other site 278137012403 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 278137012404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137012405 non-specific DNA binding site [nucleotide binding]; other site 278137012406 salt bridge; other site 278137012407 sequence-specific DNA binding site [nucleotide binding]; other site 278137012408 Cupin domain; Region: Cupin_2; cl09118 278137012409 2-isopropylmalate synthase; Validated; Region: PRK03739 278137012410 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 278137012411 active site 278137012412 catalytic residues [active] 278137012413 metal binding site [ion binding]; metal-binding site 278137012414 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 278137012415 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 278137012416 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 278137012417 active site 278137012418 catalytic site [active] 278137012419 substrate binding site [chemical binding]; other site 278137012420 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 278137012421 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 278137012422 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 278137012423 catalytic triad [active] 278137012424 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 278137012425 Integrase core domain; Region: rve; cl01316 278137012426 Integrase core domain; Region: rve_3; cl15866 278137012427 recombination protein RecR; Reviewed; Region: recR; PRK00076 278137012428 RecR protein; Region: RecR; pfam02132 278137012429 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 278137012430 putative active site [active] 278137012431 putative metal-binding site [ion binding]; other site 278137012432 tetramer interface [polypeptide binding]; other site 278137012433 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 278137012434 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 278137012435 active site 278137012436 metal binding site [ion binding]; metal-binding site 278137012437 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137012438 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 278137012439 FAD binding domain; Region: FAD_binding_4; pfam01565 278137012440 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 278137012441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137012442 S-adenosylmethionine binding site [chemical binding]; other site 278137012443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278137012444 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 278137012445 Walker A motif; other site 278137012446 ATP binding site [chemical binding]; other site 278137012447 Walker B motif; other site 278137012448 arginine finger; other site 278137012449 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 278137012450 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 278137012451 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137012452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137012453 catalytic residue [active] 278137012454 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 278137012455 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 278137012456 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137012457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012458 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 278137012459 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137012460 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 278137012461 nucleophilic elbow; other site 278137012462 catalytic triad; other site 278137012463 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 278137012464 nucleotide binding site [chemical binding]; other site 278137012465 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 278137012466 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 278137012467 active site 278137012468 DNA binding site [nucleotide binding] 278137012469 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 278137012470 DNA binding site [nucleotide binding] 278137012471 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137012472 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137012473 active site 278137012474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137012475 Helix-turn-helix domains; Region: HTH; cl00088 278137012476 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137012477 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 278137012478 classical (c) SDRs; Region: SDR_c; cd05233 278137012479 NAD(P) binding site [chemical binding]; other site 278137012480 active site 278137012481 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137012482 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137012483 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137012484 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278137012485 active site 278137012486 metal binding site [ion binding]; metal-binding site 278137012487 short chain dehydrogenase; Provisional; Region: PRK06138 278137012488 classical (c) SDRs; Region: SDR_c; cd05233 278137012489 NAD(P) binding site [chemical binding]; other site 278137012490 active site 278137012491 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 278137012492 FMN binding site [chemical binding]; other site 278137012493 dimer interface [polypeptide binding]; other site 278137012494 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 278137012495 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137012496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012497 short chain dehydrogenase; Provisional; Region: PRK08278 278137012498 NAD(P) binding site [chemical binding]; other site 278137012499 active site 278137012500 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137012501 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278137012502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012503 NAD(P) binding site [chemical binding]; other site 278137012504 active site 278137012505 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137012506 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137012507 classical (c) SDRs; Region: SDR_c; cd05233 278137012508 NAD(P) binding site [chemical binding]; other site 278137012509 active site 278137012510 choline dehydrogenase; Validated; Region: PRK02106 278137012511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012512 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 278137012513 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 278137012514 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 278137012515 active site 278137012516 DNA binding site [nucleotide binding] 278137012517 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 278137012518 DNA binding site [nucleotide binding] 278137012519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137012520 Helix-turn-helix domains; Region: HTH; cl00088 278137012521 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 278137012522 Subunit I/III interface [polypeptide binding]; other site 278137012523 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 278137012524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137012525 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 278137012526 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 278137012527 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 278137012528 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 278137012529 alpha-beta subunit interface [polypeptide binding]; other site 278137012530 alpha-gamma subunit interface [polypeptide binding]; other site 278137012531 active site 278137012532 substrate and K+ binding site; other site 278137012533 K+ binding site [ion binding]; other site 278137012534 cobalamin binding site [chemical binding]; other site 278137012535 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 278137012536 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 278137012537 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 278137012538 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137012539 inhibitor-cofactor binding pocket; inhibition site 278137012540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137012541 catalytic residue [active] 278137012542 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 278137012543 putative catalytic cysteine [active] 278137012544 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 278137012545 putative hexamer interface [polypeptide binding]; other site 278137012546 putative hexagonal pore; other site 278137012547 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 278137012548 putative hexamer interface [polypeptide binding]; other site 278137012549 putative hexagonal pore; other site 278137012550 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 278137012551 Hexamer/Pentamer interface [polypeptide binding]; other site 278137012552 central pore; other site 278137012553 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 278137012554 Hexamer interface [polypeptide binding]; other site 278137012555 Hexagonal pore residue; other site 278137012556 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 278137012557 Hexamer interface [polypeptide binding]; other site 278137012558 Hexagonal pore residue; other site 278137012559 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 278137012560 Hexamer interface [polypeptide binding]; other site 278137012561 Hexagonal pore residue; other site 278137012562 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137012563 Phosphotransferase enzyme family; Region: APH; pfam01636 278137012564 short chain dehydrogenase; Provisional; Region: PRK12829 278137012565 classical (c) SDRs; Region: SDR_c; cd05233 278137012566 NAD(P) binding site [chemical binding]; other site 278137012567 active site 278137012568 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278137012569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137012570 DNA-binding site [nucleotide binding]; DNA binding site 278137012571 UTRA domain; Region: UTRA; cl01230 278137012572 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278137012573 active site 278137012574 HIGH motif; other site 278137012575 nucleotide binding site [chemical binding]; other site 278137012576 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278137012577 active site 278137012578 KMSKS motif; other site 278137012579 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278137012580 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137012581 substrate binding pocket [chemical binding]; other site 278137012582 membrane-bound complex binding site; other site 278137012583 hinge residues; other site 278137012584 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278137012585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137012586 dimer interface [polypeptide binding]; other site 278137012587 conserved gate region; other site 278137012588 putative PBP binding loops; other site 278137012589 ABC-ATPase subunit interface; other site 278137012590 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278137012591 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 278137012592 Walker A/P-loop; other site 278137012593 ATP binding site [chemical binding]; other site 278137012594 Q-loop/lid; other site 278137012595 ABC transporter signature motif; other site 278137012596 Walker B; other site 278137012597 D-loop; other site 278137012598 H-loop/switch region; other site 278137012599 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 278137012600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012601 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137012602 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 278137012603 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 278137012604 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 278137012605 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 278137012606 Protein of unknown function (DUF732); Region: DUF732; pfam05305 278137012607 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 278137012608 Nitronate monooxygenase; Region: NMO; pfam03060 278137012609 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 278137012610 FMN binding site [chemical binding]; other site 278137012611 substrate binding site [chemical binding]; other site 278137012612 putative catalytic residue [active] 278137012613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 278137012614 Helix-turn-helix domains; Region: HTH; cl00088 278137012615 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 278137012616 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 278137012617 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 278137012618 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 278137012619 active site 278137012620 P-loop; other site 278137012621 phosphorylation site [posttranslational modification] 278137012622 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 278137012623 active site 278137012624 phosphorylation site [posttranslational modification] 278137012625 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137012626 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 278137012627 putative NAD(P) binding site [chemical binding]; other site 278137012628 catalytic Zn binding site [ion binding]; other site 278137012629 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 278137012630 nucleoside/Zn binding site; other site 278137012631 dimer interface [polypeptide binding]; other site 278137012632 catalytic motif [active] 278137012633 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 278137012634 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 278137012635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012636 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 278137012637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137012638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137012639 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278137012640 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 278137012641 Walker A/P-loop; other site 278137012642 ATP binding site [chemical binding]; other site 278137012643 Q-loop/lid; other site 278137012644 ABC transporter signature motif; other site 278137012645 Walker B; other site 278137012646 D-loop; other site 278137012647 H-loop/switch region; other site 278137012648 NMT1-like family; Region: NMT1_2; cl15260 278137012649 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 278137012650 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 278137012651 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 278137012652 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 278137012653 putative active site [active] 278137012654 putative substrate binding site [chemical binding]; other site 278137012655 ATP binding site [chemical binding]; other site 278137012656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137012657 catalytic core [active] 278137012658 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 278137012659 classical (c) SDRs; Region: SDR_c; cd05233 278137012660 NAD(P) binding site [chemical binding]; other site 278137012661 active site 278137012662 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 278137012663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137012664 Cupin domain; Region: Cupin_2; cl09118 278137012665 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 278137012666 active site 278137012667 metal binding site [ion binding]; metal-binding site 278137012668 homotetramer interface [polypeptide binding]; other site 278137012669 Transposase; Region: DEDD_Tnp_IS110; pfam01548 278137012670 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 278137012671 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 278137012672 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 278137012673 D-pathway; other site 278137012674 Putative ubiquinol binding site [chemical binding]; other site 278137012675 Low-spin heme (heme b) binding site [chemical binding]; other site 278137012676 Putative water exit pathway; other site 278137012677 Binuclear center (heme o3/CuB) [ion binding]; other site 278137012678 K-pathway; other site 278137012679 Putative proton exit pathway; other site 278137012680 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 278137012681 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278137012682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137012683 homodimer interface [polypeptide binding]; other site 278137012684 catalytic residue [active] 278137012685 enoyl-CoA hydratase; Provisional; Region: PRK06142 278137012686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 278137012687 substrate binding site [chemical binding]; other site 278137012688 oxyanion hole (OAH) forming residues; other site 278137012689 trimer interface [polypeptide binding]; other site 278137012690 DoxX; Region: DoxX; cl00976 278137012691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137012692 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 278137012693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137012694 Helix-turn-helix domains; Region: HTH; cl00088 278137012695 Helix-turn-helix domains; Region: HTH; cl00088 278137012696 alcohol dehydrogenase; Provisional; Region: PTZ00354 278137012697 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 278137012698 NAD(P) binding site [chemical binding]; other site 278137012699 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 278137012700 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 278137012701 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278137012702 catalytic residue [active] 278137012703 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 278137012704 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 278137012705 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 278137012706 Walker A/P-loop; other site 278137012707 ATP binding site [chemical binding]; other site 278137012708 Q-loop/lid; other site 278137012709 ABC transporter signature motif; other site 278137012710 Walker B; other site 278137012711 D-loop; other site 278137012712 H-loop/switch region; other site 278137012713 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 278137012714 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137012715 active site 278137012716 ABC-2 type transporter; Region: ABC2_membrane; cl11417 278137012717 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137012718 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 278137012719 Helix-turn-helix domains; Region: HTH; cl00088 278137012720 Integrase core domain; Region: rve; cl01316 278137012721 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 278137012722 Uncharacterized conserved protein [Function unknown]; Region: COG2128 278137012723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137012724 DNA-binding site [nucleotide binding]; DNA binding site 278137012725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278137012726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137012727 homodimer interface [polypeptide binding]; other site 278137012728 catalytic residue [active] 278137012729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 278137012730 Transposase; Region: DDE_Tnp_ISL3; pfam01610 278137012731 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137012732 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137012733 active site 278137012734 GtrA-like protein; Region: GtrA; cl00971 278137012735 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 278137012736 FAD binding domain; Region: FAD_binding_4; pfam01565 278137012737 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 278137012738 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278137012739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012741 active site 278137012742 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 278137012743 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 278137012744 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 278137012745 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 278137012746 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 278137012747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278137012748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278137012749 active site 278137012750 ATP binding site [chemical binding]; other site 278137012751 substrate binding site [chemical binding]; other site 278137012752 activation loop (A-loop); other site 278137012753 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 278137012754 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 278137012755 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137012756 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 278137012757 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137012758 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 278137012759 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722 278137012760 active site 278137012761 Acyl transferase domain; Region: Acyl_transf_1; cl08282 278137012762 Phosphopantetheine attachment site; Region: PP-binding; cl09936 278137012763 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 278137012764 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 278137012765 AMP-binding enzyme; Region: AMP-binding; cl15778 278137012766 Cutinase; Region: Cutinase; pfam01083 278137012767 Predicted esterase [General function prediction only]; Region: COG0627 278137012768 Predicted esterase [General function prediction only]; Region: COG0627 278137012769 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137012770 UbiA prenyltransferase family; Region: UbiA; cl00337 278137012771 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 278137012772 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278137012773 active site 278137012774 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 278137012775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012776 UDP-galactopyranose mutase; Region: GLF; pfam03275 278137012777 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 278137012778 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 278137012779 amidase catalytic site [active] 278137012780 Zn binding residues [ion binding]; other site 278137012781 substrate binding site [chemical binding]; other site 278137012782 LGFP repeat; Region: LGFP; pfam08310 278137012783 Predicted ATPase [General function prediction only]; Region: COG3899 278137012784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137012785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278137012786 DNA binding residues [nucleotide binding] 278137012787 dimerization interface [polypeptide binding]; other site 278137012788 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278137012789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137012790 active site 278137012791 motif I; other site 278137012792 motif II; other site 278137012793 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137012794 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 278137012795 putative acyl-acceptor binding pocket; other site 278137012796 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 278137012797 putative acyl-acceptor binding pocket; other site 278137012798 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137012799 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 278137012800 seryl-tRNA synthetase; Provisional; Region: PRK05431 278137012801 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 278137012802 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 278137012803 dimer interface [polypeptide binding]; other site 278137012804 active site 278137012805 motif 1; other site 278137012806 motif 2; other site 278137012807 motif 3; other site 278137012808 Septum formation; Region: Septum_form; pfam13845 278137012809 Septum formation; Region: Septum_form; pfam13845 278137012810 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 278137012811 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278137012812 catalytic core [active] 278137012813 prephenate dehydratase; Provisional; Region: PRK11898 278137012814 Prephenate dehydratase; Region: PDT; pfam00800 278137012815 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 278137012816 putative L-Phe binding site [chemical binding]; other site 278137012817 CAAX protease self-immunity; Region: Abi; cl00558 278137012818 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 278137012819 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 278137012820 Ferritin-like domain; Region: Ferritin; pfam00210 278137012821 ferroxidase diiron center [ion binding]; other site 278137012822 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 278137012823 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 278137012824 putative active site [active] 278137012825 catalytic site [active] 278137012826 putative metal binding site [ion binding]; other site 278137012827 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 278137012828 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278137012829 active site residue [active] 278137012830 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 278137012831 Catalytic site [active] 278137012832 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 278137012833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 278137012834 Bacterial Ig-like domain; Region: Big_5; cl01012 278137012835 Copper resistance protein D; Region: CopD; cl00563 278137012836 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 278137012837 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137012838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012839 NAD(P) binding pocket [chemical binding]; other site 278137012840 DNA polymerase IV; Validated; Region: PRK03858 278137012841 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 278137012842 active site 278137012843 DNA binding site [nucleotide binding] 278137012844 hypothetical protein; Provisional; Region: PRK07945 278137012845 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 278137012846 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278137012847 dimerization interface [polypeptide binding]; other site 278137012848 putative DNA binding site [nucleotide binding]; other site 278137012849 putative Zn2+ binding site [ion binding]; other site 278137012850 Sulfate transporter family; Region: Sulfate_transp; cl15842 278137012851 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 278137012852 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137012853 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 278137012854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137012855 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 278137012856 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 278137012857 active site 278137012858 dimer interface [polypeptide binding]; other site 278137012859 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 278137012860 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 278137012861 active site 278137012862 FMN binding site [chemical binding]; other site 278137012863 substrate binding site [chemical binding]; other site 278137012864 3Fe-4S cluster binding site [ion binding]; other site 278137012865 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 278137012866 domain interface; other site 278137012867 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 278137012868 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 278137012869 dimerization interface [polypeptide binding]; other site 278137012870 DPS ferroxidase diiron center [ion binding]; other site 278137012871 ion pore; other site 278137012872 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 278137012873 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 278137012874 minor groove reading motif; other site 278137012875 helix-hairpin-helix signature motif; other site 278137012876 active site 278137012877 Domain of unknown function (DUF427); Region: DUF427; cl00998 278137012878 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 278137012879 FAD dependent oxidoreductase; Region: DAO; pfam01266 278137012880 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 278137012881 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 278137012882 putative NADP binding site [chemical binding]; other site 278137012883 putative substrate binding site [chemical binding]; other site 278137012884 active site 278137012885 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 278137012886 SelR domain; Region: SelR; pfam01641 278137012887 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 278137012888 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 278137012889 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 278137012890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137012891 Helix-turn-helix domains; Region: HTH; cl00088 278137012892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137012893 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 278137012894 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 278137012895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278137012896 S-adenosylmethionine binding site [chemical binding]; other site 278137012897 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278137012898 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 278137012899 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137012900 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137012901 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 278137012902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 278137012903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 278137012904 active site 278137012905 PAS fold; Region: PAS_3; pfam08447 278137012906 ANTAR domain; Region: ANTAR; cl04297 278137012907 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 278137012908 Isochorismatase family; Region: Isochorismatase; pfam00857 278137012909 catalytic triad [active] 278137012910 metal binding site [ion binding]; metal-binding site 278137012911 conserved cis-peptide bond; other site 278137012912 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 278137012913 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 278137012914 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 278137012915 active site 278137012916 catalytic site [active] 278137012917 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 278137012918 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137012919 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 278137012920 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 278137012921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278137012922 active site 278137012923 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 278137012924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137012925 Walker A/P-loop; other site 278137012926 ATP binding site [chemical binding]; other site 278137012927 Q-loop/lid; other site 278137012928 ABC transporter signature motif; other site 278137012929 Walker B; other site 278137012930 D-loop; other site 278137012931 H-loop/switch region; other site 278137012932 TOBE domain; Region: TOBE_2; cl01440 278137012933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137012934 dimer interface [polypeptide binding]; other site 278137012935 conserved gate region; other site 278137012936 putative PBP binding loops; other site 278137012937 ABC-ATPase subunit interface; other site 278137012938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 278137012939 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 278137012940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278137012941 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137012942 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 278137012943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137012944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137012945 DNA binding residues [nucleotide binding] 278137012946 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 278137012947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137012948 putative substrate translocation pore; other site 278137012949 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137012950 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 278137012951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278137012952 motif II; other site 278137012953 Rhomboid family; Region: Rhomboid; cl11446 278137012954 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 278137012955 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278137012956 active site 278137012957 metal binding site [ion binding]; metal-binding site 278137012958 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 278137012959 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137012960 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 278137012961 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 278137012962 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278137012963 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 278137012964 putative NAD(P) binding site [chemical binding]; other site 278137012965 catalytic Zn binding site [ion binding]; other site 278137012966 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 278137012967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137012968 ATP binding site [chemical binding]; other site 278137012969 putative Mg++ binding site [ion binding]; other site 278137012970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137012971 Helicase associated domain (HA2); Region: HA2; cl04503 278137012972 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 278137012973 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 278137012974 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 278137012975 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 278137012976 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 278137012977 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 278137012978 Domain of unknown function (DUF222); Region: DUF222; pfam02720 278137012979 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278137012980 active site 278137012981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 278137012982 Transposase; Region: DDE_Tnp_ISL3; pfam01610 278137012983 hypothetical protein; Provisional; Region: PRK06062 278137012984 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 278137012985 inhibitor-cofactor binding pocket; inhibition site 278137012986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137012987 catalytic residue [active] 278137012988 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 278137012989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137012990 metal binding site [ion binding]; metal-binding site 278137012991 active site 278137012992 I-site; other site 278137012993 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 278137012994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137012995 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 278137012996 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 278137012997 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 278137012998 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 278137012999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 278137013000 MOSC domain; Region: MOSC; pfam03473 278137013001 Mechanosensitive ion channel; Region: MS_channel; pfam00924 278137013002 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 278137013003 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 278137013004 putative active site [active] 278137013005 putative CoA binding site [chemical binding]; other site 278137013006 nudix motif; other site 278137013007 metal binding site [ion binding]; metal-binding site 278137013008 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 278137013009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137013010 putative methyltransferase; Provisional; Region: PRK14968 278137013011 Cutinase; Region: Cutinase; pfam01083 278137013012 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 278137013013 intracellular protease, PfpI family; Region: PfpI; TIGR01382 278137013014 proposed catalytic triad [active] 278137013015 conserved cys residue [active] 278137013016 Helix-turn-helix domains; Region: HTH; cl00088 278137013017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137013018 putative substrate translocation pore; other site 278137013019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278137013020 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 278137013021 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 278137013022 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 278137013023 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 278137013024 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 278137013025 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 278137013026 anti sigma factor interaction site; other site 278137013027 regulatory phosphorylation site [posttranslational modification]; other site 278137013028 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 278137013029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137013030 NAD(P) binding site [chemical binding]; other site 278137013031 active site 278137013032 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 278137013033 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 278137013034 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 278137013035 active site 278137013036 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 278137013037 active site 278137013038 NAD binding site [chemical binding]; other site 278137013039 metal binding site [ion binding]; metal-binding site 278137013040 classical (c) SDRs; Region: SDR_c; cd05233 278137013041 NAD(P) binding site [chemical binding]; other site 278137013042 active site 278137013043 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 278137013044 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 278137013045 putative active site [active] 278137013046 putative metal binding site [ion binding]; other site 278137013047 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 278137013048 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 278137013049 active site 278137013050 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 278137013051 catalytic triad [active] 278137013052 dimer interface [polypeptide binding]; other site 278137013053 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 278137013054 hydrophobic ligand binding site; other site 278137013055 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 278137013056 putative acyl-acceptor binding pocket; other site 278137013057 ATP-dependent helicase; Provisional; Region: PRK13767 278137013058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278137013059 ATP binding site [chemical binding]; other site 278137013060 putative Mg++ binding site [ion binding]; other site 278137013061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278137013062 nucleotide binding region [chemical binding]; other site 278137013063 ATP-binding site [chemical binding]; other site 278137013064 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 278137013065 Short C-terminal domain; Region: SHOCT; cl01373 278137013066 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137013067 amidase; Provisional; Region: PRK06529 278137013068 Amidase; Region: Amidase; cl11426 278137013069 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 278137013070 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 278137013071 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 278137013072 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 278137013073 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 278137013074 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 278137013075 conserved cys residue [active] 278137013076 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 278137013077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278137013078 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 278137013079 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 278137013080 conserved cys residue [active] 278137013081 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 278137013082 active site 278137013083 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 278137013084 Putative cyclase; Region: Cyclase; cl00814 278137013085 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 278137013086 putative active site [active] 278137013087 catalytic site [active] 278137013088 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 278137013089 putative active site [active] 278137013090 catalytic site [active] 278137013091 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 278137013092 CheB methylesterase; Region: CheB_methylest; pfam01339 278137013093 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 278137013094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137013095 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 278137013096 GAF domain; Region: GAF; cl15785 278137013097 GAF domain; Region: GAF_2; pfam13185 278137013098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137013099 dimer interface [polypeptide binding]; other site 278137013100 phosphorylation site [posttranslational modification] 278137013101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137013102 ATP binding site [chemical binding]; other site 278137013103 Mg2+ binding site [ion binding]; other site 278137013104 G-X-G motif; other site 278137013105 Response regulator receiver domain; Region: Response_reg; pfam00072 278137013106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137013107 active site 278137013108 phosphorylation site [posttranslational modification] 278137013109 intermolecular recognition site; other site 278137013110 dimerization interface [polypeptide binding]; other site 278137013111 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 278137013112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 278137013113 Response regulator receiver domain; Region: Response_reg; pfam00072 278137013114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137013115 active site 278137013116 phosphorylation site [posttranslational modification] 278137013117 intermolecular recognition site; other site 278137013118 dimerization interface [polypeptide binding]; other site 278137013119 Response regulator receiver domain; Region: Response_reg; pfam00072 278137013120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137013121 active site 278137013122 phosphorylation site [posttranslational modification] 278137013123 intermolecular recognition site; other site 278137013124 dimerization interface [polypeptide binding]; other site 278137013125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 278137013126 putative active site [active] 278137013127 heme pocket [chemical binding]; other site 278137013128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278137013129 metal binding site [ion binding]; metal-binding site 278137013130 active site 278137013131 I-site; other site 278137013132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278137013133 EVE domain; Region: EVE; cl00728 278137013134 Domain of unknown function (DUF385); Region: DUF385; cl04387 278137013135 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 278137013136 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 278137013137 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278137013138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137013139 Walker A/P-loop; other site 278137013140 ATP binding site [chemical binding]; other site 278137013141 Q-loop/lid; other site 278137013142 ABC transporter signature motif; other site 278137013143 Walker B; other site 278137013144 H-loop/switch region; other site 278137013145 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 278137013146 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 278137013147 active site 278137013148 catalytic site [active] 278137013149 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 278137013150 active site 278137013151 catalytic site [active] 278137013152 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 278137013153 Predicted membrane protein [Function unknown]; Region: COG2860 278137013154 UPF0126 domain; Region: UPF0126; pfam03458 278137013155 UPF0126 domain; Region: UPF0126; pfam03458 278137013156 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 278137013157 heme binding pocket [chemical binding]; other site 278137013158 heme ligand [chemical binding]; other site 278137013159 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 278137013160 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 278137013161 active site 278137013162 FMN binding site [chemical binding]; other site 278137013163 substrate binding site [chemical binding]; other site 278137013164 3Fe-4S cluster binding site [ion binding]; other site 278137013165 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278137013166 catalytic residues [active] 278137013167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137013168 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 278137013169 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 278137013170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137013171 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278137013172 active site residue [active] 278137013173 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278137013174 active site residue [active] 278137013175 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278137013176 active site residue [active] 278137013177 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 278137013178 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 278137013179 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 278137013180 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 278137013181 putative homotetramer interface [polypeptide binding]; other site 278137013182 putative homodimer interface [polypeptide binding]; other site 278137013183 putative allosteric switch controlling residues; other site 278137013184 putative metal binding site [ion binding]; other site 278137013185 putative homodimer-homodimer interface [polypeptide binding]; other site 278137013186 Domain of unknown function DUF302; Region: DUF302; cl01364 278137013187 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 278137013188 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 278137013189 active site residue [active] 278137013190 Domain of unknown function (DUF202); Region: DUF202; cl09954 278137013191 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 278137013192 classical (c) SDRs; Region: SDR_c; cd05233 278137013193 NAD(P) binding site [chemical binding]; other site 278137013194 active site 278137013195 Helix-turn-helix domains; Region: HTH; cl00088 278137013196 Cobalt transport protein; Region: CbiQ; cl00463 278137013197 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 278137013198 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 278137013199 Walker A/P-loop; other site 278137013200 ATP binding site [chemical binding]; other site 278137013201 Q-loop/lid; other site 278137013202 ABC transporter signature motif; other site 278137013203 Walker B; other site 278137013204 D-loop; other site 278137013205 H-loop/switch region; other site 278137013206 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 278137013207 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 278137013208 Walker A/P-loop; other site 278137013209 ATP binding site [chemical binding]; other site 278137013210 Q-loop/lid; other site 278137013211 ABC transporter signature motif; other site 278137013212 Walker B; other site 278137013213 D-loop; other site 278137013214 H-loop/switch region; other site 278137013215 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 278137013216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137013217 active site 278137013218 Domain of unknown function (DUF309); Region: DUF309; cl00667 278137013219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278137013220 Helix-turn-helix domains; Region: HTH; cl00088 278137013221 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 278137013222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137013223 Predicted membrane protein [Function unknown]; Region: COG4270 278137013224 Helix-turn-helix domains; Region: HTH; cl00088 278137013225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137013226 DNA-binding site [nucleotide binding]; DNA binding site 278137013227 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 278137013228 FAD binding domain; Region: FAD_binding_4; pfam01565 278137013229 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 278137013230 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 278137013231 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 278137013232 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 278137013233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137013234 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 278137013235 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137013236 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 278137013237 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 278137013238 Uncharacterized conserved protein [Function unknown]; Region: COG2966 278137013239 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 278137013240 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 278137013241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137013242 citrate-proton symporter; Provisional; Region: PRK15075 278137013243 putative substrate translocation pore; other site 278137013244 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137013245 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 278137013246 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137013247 ABC transporter signature motif; other site 278137013248 Walker B; other site 278137013249 D-loop; other site 278137013250 H-loop/switch region; other site 278137013251 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 278137013252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278137013253 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 278137013254 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 278137013255 substrate binding site [chemical binding]; other site 278137013256 ATP binding site [chemical binding]; other site 278137013257 Survival protein SurE; Region: SurE; cl00448 278137013258 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 278137013259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 278137013260 Transposase; Region: DDE_Tnp_ISL3; pfam01610 278137013261 multidrug resistance protein MdtH; Provisional; Region: PRK11646 278137013262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278137013263 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 278137013264 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 278137013265 dimer interface [polypeptide binding]; other site 278137013266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278137013267 catalytic residue [active] 278137013268 Peptidase family M48; Region: Peptidase_M48; cl12018 278137013269 Helix-turn-helix domains; Region: HTH; cl00088 278137013270 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 278137013271 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 278137013272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137013273 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137013274 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 278137013275 putative homotetramer interface [polypeptide binding]; other site 278137013276 putative homodimer interface [polypeptide binding]; other site 278137013277 putative allosteric switch controlling residues; other site 278137013278 putative metal binding site [ion binding]; other site 278137013279 putative homodimer-homodimer interface [polypeptide binding]; other site 278137013280 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 278137013281 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 278137013282 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 278137013283 metal-binding site [ion binding] 278137013284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278137013285 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 278137013286 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 278137013287 metal-binding site [ion binding] 278137013288 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137013289 Bacterial Ig-like domain; Region: Big_5; cl01012 278137013290 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 278137013291 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 278137013292 NlpC/P60 family; Region: NLPC_P60; cl11438 278137013293 putative transposase OrfB; Reviewed; Region: PHA02517 278137013294 HTH-like domain; Region: HTH_21; pfam13276 278137013295 Integrase core domain; Region: rve; cl01316 278137013296 Integrase core domain; Region: rve_3; cl15866 278137013297 Helix-turn-helix domains; Region: HTH; cl00088 278137013298 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278137013299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278137013300 active site 278137013301 phosphorylation site [posttranslational modification] 278137013302 intermolecular recognition site; other site 278137013303 dimerization interface [polypeptide binding]; other site 278137013304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278137013305 DNA binding site [nucleotide binding] 278137013306 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 278137013307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278137013308 dimer interface [polypeptide binding]; other site 278137013309 phosphorylation site [posttranslational modification] 278137013310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278137013311 ATP binding site [chemical binding]; other site 278137013312 Mg2+ binding site [ion binding]; other site 278137013313 G-X-G motif; other site 278137013314 Domain of unknown function (DUF305); Region: DUF305; cl15795 278137013315 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 278137013316 Asp-box motif; other site 278137013317 NlpC/P60 family; Region: NLPC_P60; cl11438 278137013318 Fic family protein [Function unknown]; Region: COG3177 278137013319 Fic/DOC family; Region: Fic; cl00960 278137013320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278137013321 non-specific DNA binding site [nucleotide binding]; other site 278137013322 salt bridge; other site 278137013323 sequence-specific DNA binding site [nucleotide binding]; other site 278137013324 TniQ; Region: TniQ; pfam06527 278137013325 AAA domain; Region: AAA_22; pfam13401 278137013326 Helix-turn-helix domains; Region: HTH; cl00088 278137013327 Integrase core domain; Region: rve; cl01316 278137013328 TniQ; Region: TniQ; pfam06527 278137013329 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278137013330 translation initiation factor IF-2; Validated; Region: infB; PRK05306 278137013331 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278137013332 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 278137013333 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 278137013334 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137013335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137013336 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 278137013337 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 278137013338 HsdM N-terminal domain; Region: HsdM_N; pfam12161 278137013339 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 278137013340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137013341 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 278137013342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137013343 LabA_like proteins; Region: LabA_like; cd06167 278137013344 putative metal binding site [ion binding]; other site 278137013345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 278137013346 TniQ; Region: TniQ; pfam06527 278137013347 Helix-turn-helix domains; Region: HTH; cl00088 278137013348 AAA domain; Region: AAA_22; pfam13401 278137013349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137013350 Helix-turn-helix domains; Region: HTH; cl00088 278137013351 Integrase core domain; Region: rve; cl01316 278137013352 Integrase core domain; Region: rve_3; cl15866 278137013353 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 278137013354 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 278137013355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 278137013356 Walker A motif; other site 278137013357 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 278137013358 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 278137013359 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 278137013360 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 278137013361 Walker A motif; other site 278137013362 ATP binding site [chemical binding]; other site 278137013363 Walker B motif; other site 278137013364 DNA binding loops [nucleotide binding] 278137013365 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 278137013366 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 278137013367 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 278137013368 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 278137013369 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 278137013370 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 278137013371 dimer interface [polypeptide binding]; other site 278137013372 ssDNA binding site [nucleotide binding]; other site 278137013373 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278137013374 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 278137013375 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 278137013376 Transglycosylase; Region: Transgly; cl07896 278137013377 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 278137013378 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 278137013379 Helix-turn-helix domains; Region: HTH; cl00088 278137013380 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 278137013381 hypothetical protein; Provisional; Region: PRK01346 278137013382 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 278137013383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278137013384 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 278137013385 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 278137013386 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 278137013387 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 278137013388 Transcriptional regulators [Transcription]; Region: GntR; COG1802 278137013389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278137013390 DNA-binding site [nucleotide binding]; DNA binding site 278137013391 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278137013392 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278137013393 substrate binding pocket [chemical binding]; other site 278137013394 membrane-bound complex binding site; other site 278137013395 hinge residues; other site 278137013396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278137013397 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278137013398 dimer interface [polypeptide binding]; other site 278137013399 conserved gate region; other site 278137013400 putative PBP binding loops; other site 278137013401 ABC-ATPase subunit interface; other site 278137013402 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278137013403 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 278137013404 Walker A/P-loop; other site 278137013405 ATP binding site [chemical binding]; other site 278137013406 Q-loop/lid; other site 278137013407 ABC transporter signature motif; other site 278137013408 Walker B; other site 278137013409 D-loop; other site 278137013410 H-loop/switch region; other site 278137013411 Helix-turn-helix domains; Region: HTH; cl00088 278137013412 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 278137013413 classical (c) SDRs; Region: SDR_c; cd05233 278137013414 NAD(P) binding site [chemical binding]; other site 278137013415 active site 278137013416 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 278137013417 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 278137013418 HIGH motif; other site 278137013419 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 278137013420 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278137013421 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278137013422 active site 278137013423 KMSKS motif; other site 278137013424 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 278137013425 tRNA binding surface [nucleotide binding]; other site 278137013426 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 278137013427 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 278137013428 H+ Antiporter protein; Region: 2A0121; TIGR00900 278137013429 TIGR03084 family protein; Region: TIGR03084 278137013430 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 278137013431 Wyosine base formation; Region: Wyosine_form; pfam08608 278137013432 NlpC/P60 family; Region: NLPC_P60; cl11438 278137013433 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 278137013434 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 278137013435 active site 278137013436 NTP binding site [chemical binding]; other site 278137013437 metal binding triad [ion binding]; metal-binding site 278137013438 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 278137013439 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278137013440 Zn2+ binding site [ion binding]; other site 278137013441 Mg2+ binding site [ion binding]; other site 278137013442 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 278137013443 active site 278137013444 Ap6A binding site [chemical binding]; other site 278137013445 nudix motif; other site 278137013446 metal binding site [ion binding]; metal-binding site 278137013447 MviN-like protein; Region: MVIN; pfam03023 278137013448 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 278137013449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278137013450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278137013451 DNA binding residues [nucleotide binding] 278137013452 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 278137013453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278137013454 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278137013455 catalytic residues [active] 278137013456 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 278137013457 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 278137013458 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 278137013459 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 278137013460 active site 278137013461 metal binding site [ion binding]; metal-binding site 278137013462 ParB-like partition proteins; Region: parB_part; TIGR00180 278137013463 ParB-like nuclease domain; Region: ParBc; cl02129 278137013464 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 278137013465 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137013466 P-loop; other site 278137013467 Magnesium ion binding site [ion binding]; other site 278137013468 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 278137013469 Magnesium ion binding site [ion binding]; other site 278137013470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 278137013471 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 278137013472 G-X-X-G motif; other site 278137013473 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 278137013474 RxxxH motif; other site 278137013475 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 278137013476 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 278137013477 Haemolytic domain; Region: Haemolytic; cl00506 278137013478 Ribonuclease P; Region: Ribonuclease_P; cl00457 278137013479 Ribosomal protein L34; Region: Ribosomal_L34; cl00370