-- dump date   	20140619_155541
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
700508000001	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
700508000002	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
700508000003	active site
700508000004	DNA binding site [nucleotide binding]
700508000005	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
700508000006	DNA binding site [nucleotide binding]
700508000007	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700508000008	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
700508000009	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508000010	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
700508000011	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
700508000012	active site
700508000013	HIGH motif; other site
700508000014	nucleotide binding site [chemical binding]; other site
700508000015	active site
700508000016	KMSKS motif; other site
700508000017	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508000018	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508000019	substrate binding pocket [chemical binding]; other site
700508000020	membrane-bound complex binding site; other site
700508000021	hinge residues; other site
700508000022	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700508000023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508000024	dimer interface [polypeptide binding]; other site
700508000025	conserved gate region; other site
700508000026	putative PBP binding loops; other site
700508000027	ABC-ATPase subunit interface; other site
700508000028	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700508000029	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700508000030	Walker A/P-loop; other site
700508000031	ATP binding site [chemical binding]; other site
700508000032	Q-loop/lid; other site
700508000033	ABC transporter signature motif; other site
700508000034	Walker B; other site
700508000035	D-loop; other site
700508000036	H-loop/switch region; other site
700508000037	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
700508000038	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
700508000039	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
700508000040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508000041	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
700508000042	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
700508000043	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
700508000044	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
700508000045	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508000046	PE-PPE domain; Region: PE-PPE; pfam08237
700508000047	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700508000048	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
700508000049	putative NAD(P) binding site [chemical binding]; other site
700508000050	catalytic Zn binding site [ion binding]; other site
700508000051	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
700508000052	HEXXH motif domain; Region: mod_HExxH; TIGR04267
700508000053	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700508000054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508000055	Walker A/P-loop; other site
700508000056	ATP binding site [chemical binding]; other site
700508000057	Q-loop/lid; other site
700508000058	ABC transporter signature motif; other site
700508000059	Walker B; other site
700508000060	D-loop; other site
700508000061	H-loop/switch region; other site
700508000062	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
700508000063	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
700508000064	active site
700508000065	catalytic tetrad [active]
700508000066	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
700508000067	Ligand Binding Site [chemical binding]; other site
700508000068	Molecular Tunnel; other site
700508000069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
700508000070	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
700508000071	nucleoside/Zn binding site; other site
700508000072	dimer interface [polypeptide binding]; other site
700508000073	catalytic motif [active]
700508000074	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
700508000075	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
700508000076	prephenate dehydrogenase; Validated; Region: PRK08507
700508000077	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
700508000078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508000079	dimer interface [polypeptide binding]; other site
700508000080	conserved gate region; other site
700508000081	putative PBP binding loops; other site
700508000082	ABC-ATPase subunit interface; other site
700508000083	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
700508000084	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
700508000085	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
700508000086	Walker A/P-loop; other site
700508000087	ATP binding site [chemical binding]; other site
700508000088	Q-loop/lid; other site
700508000089	ABC transporter signature motif; other site
700508000090	Walker B; other site
700508000091	D-loop; other site
700508000092	H-loop/switch region; other site
700508000093	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
700508000094	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
700508000095	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
700508000096	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
700508000097	Phosphotransferase enzyme family; Region: APH; pfam01636
700508000098	putative active site [active]
700508000099	putative substrate binding site [chemical binding]; other site
700508000100	ATP binding site [chemical binding]; other site
700508000101	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508000102	catalytic core [active]
700508000103	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
700508000104	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508000105	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700508000106	active site
700508000107	metal binding site [ion binding]; metal-binding site
700508000108	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
700508000109	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508000110	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
700508000111	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508000112	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508000113	homodimer interface [polypeptide binding]; other site
700508000114	catalytic residue [active]
700508000115	enoyl-CoA hydratase; Provisional; Region: PRK06142
700508000116	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508000117	substrate binding site [chemical binding]; other site
700508000118	oxyanion hole (OAH) forming residues; other site
700508000119	trimer interface [polypeptide binding]; other site
700508000120	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
700508000121	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
700508000122	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
700508000123	PE-PPE domain; Region: PE-PPE; pfam08237
700508000124	MarR family; Region: MarR; pfam01047
700508000125	MarR family; Region: MarR_2; cl17246
700508000126	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
700508000127	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
700508000128	NAD(P) binding site [chemical binding]; other site
700508000129	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
700508000130	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508000131	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508000132	catalytic residue [active]
700508000133	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
700508000134	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
700508000135	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
700508000136	Walker A/P-loop; other site
700508000137	ATP binding site [chemical binding]; other site
700508000138	Q-loop/lid; other site
700508000139	ABC transporter signature motif; other site
700508000140	Walker B; other site
700508000141	D-loop; other site
700508000142	H-loop/switch region; other site
700508000143	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700508000144	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700508000145	active site
700508000146	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
700508000147	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
700508000148	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508000149	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700508000150	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700508000151	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
700508000152	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508000153	DNA-binding site [nucleotide binding]; DNA binding site
700508000154	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508000155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508000156	homodimer interface [polypeptide binding]; other site
700508000157	catalytic residue [active]
700508000158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
700508000159	Predicted membrane protein [Function unknown]; Region: COG2246
700508000160	GtrA-like protein; Region: GtrA; pfam04138
700508000161	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700508000162	FAD binding domain; Region: FAD_binding_4; pfam01565
700508000163	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
700508000164	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
700508000165	classical (c) SDRs; Region: SDR_c; cd05233
700508000166	NAD(P) binding site [chemical binding]; other site
700508000167	active site
700508000168	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
700508000169	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
700508000170	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
700508000171	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
700508000172	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700508000173	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
700508000174	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700508000175	Di-iron ligands [ion binding]; other site
700508000176	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
700508000177	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
700508000178	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508000179	RDD family; Region: RDD; pfam06271
700508000180	RibD C-terminal domain; Region: RibD_C; cl17279
700508000181	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
700508000182	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
700508000183	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
700508000184	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
700508000185	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
700508000186	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
700508000187	active site
700508000188	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
700508000189	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
700508000190	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
700508000191	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
700508000192	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
700508000193	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
700508000194	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
700508000195	acyl-activating enzyme (AAE) consensus motif; other site
700508000196	active site
700508000197	Cutinase; Region: Cutinase; pfam01083
700508000198	Predicted esterase [General function prediction only]; Region: COG0627
700508000199	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508000200	Predicted esterase [General function prediction only]; Region: COG0627
700508000201	Putative esterase; Region: Esterase; pfam00756
700508000202	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
700508000203	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700508000204	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700508000205	active site
700508000206	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
700508000207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508000208	UDP-galactopyranose mutase; Region: GLF; pfam03275
700508000209	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
700508000210	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
700508000211	amidase catalytic site [active]
700508000212	Zn binding residues [ion binding]; other site
700508000213	substrate binding site [chemical binding]; other site
700508000214	LGFP repeat; Region: LGFP; pfam08310
700508000215	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508000216	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
700508000217	active site
700508000218	motif I; other site
700508000219	motif II; other site
700508000220	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700508000221	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700508000222	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
700508000223	putative acyl-acceptor binding pocket; other site
700508000224	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700508000225	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700508000226	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
700508000227	iron-sulfur cluster [ion binding]; other site
700508000228	[2Fe-2S] cluster binding site [ion binding]; other site
700508000229	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
700508000230	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
700508000231	MOSC domain; Region: MOSC; pfam03473
700508000232	seryl-tRNA synthetase; Provisional; Region: PRK05431
700508000233	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
700508000234	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
700508000235	dimer interface [polypeptide binding]; other site
700508000236	active site
700508000237	motif 1; other site
700508000238	motif 2; other site
700508000239	motif 3; other site
700508000240	Septum formation; Region: Septum_form; pfam13845
700508000241	Septum formation; Region: Septum_form; pfam13845
700508000242	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
700508000243	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508000244	catalytic core [active]
700508000245	prephenate dehydratase; Provisional; Region: PRK11898
700508000246	Prephenate dehydratase; Region: PDT; pfam00800
700508000247	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
700508000248	putative L-Phe binding site [chemical binding]; other site
700508000249	CAAX protease self-immunity; Region: Abi; pfam02517
700508000250	Transcriptional regulator [Transcription]; Region: LytR; COG1316
700508000251	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
700508000252	Ferritin-like domain; Region: Ferritin; pfam00210
700508000253	ferroxidase diiron center [ion binding]; other site
700508000254	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
700508000255	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
700508000256	putative active site [active]
700508000257	catalytic site [active]
700508000258	putative metal binding site [ion binding]; other site
700508000259	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
700508000260	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
700508000261	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
700508000262	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
700508000263	CopC domain; Region: CopC; pfam04234
700508000264	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
700508000265	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
700508000266	DNA binding residues [nucleotide binding]
700508000267	dimer interface [polypeptide binding]; other site
700508000268	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
700508000269	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
700508000270	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508000271	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508000272	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508000273	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000274	DNA polymerase IV; Validated; Region: PRK03858
700508000275	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
700508000276	active site
700508000277	DNA binding site [nucleotide binding]
700508000278	hypothetical protein; Provisional; Region: PRK07945
700508000279	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
700508000280	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
700508000281	active site
700508000282	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508000283	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
700508000284	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
700508000285	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508000286	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
700508000287	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
700508000288	active site
700508000289	dimer interface [polypeptide binding]; other site
700508000290	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
700508000291	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
700508000292	active site
700508000293	FMN binding site [chemical binding]; other site
700508000294	substrate binding site [chemical binding]; other site
700508000295	3Fe-4S cluster binding site [ion binding]; other site
700508000296	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
700508000297	domain interface; other site
700508000298	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508000299	CoenzymeA binding site [chemical binding]; other site
700508000300	subunit interaction site [polypeptide binding]; other site
700508000301	PHB binding site; other site
700508000302	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
700508000303	amphipathic channel; other site
700508000304	Asn-Pro-Ala signature motifs; other site
700508000305	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
700508000306	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
700508000307	dimerization interface [polypeptide binding]; other site
700508000308	DPS ferroxidase diiron center [ion binding]; other site
700508000309	ion pore; other site
700508000310	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
700508000311	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
700508000312	minor groove reading motif; other site
700508000313	helix-hairpin-helix signature motif; other site
700508000314	substrate binding pocket [chemical binding]; other site
700508000315	active site
700508000316	Domain of unknown function (DUF427); Region: DUF427; pfam04248
700508000317	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700508000318	hydrophobic ligand binding site; other site
700508000319	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
700508000320	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
700508000321	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
700508000322	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508000323	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508000324	active site
700508000325	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508000326	methionine sulfoxide reductase A; Provisional; Region: PRK14054
700508000327	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508000328	Cytochrome P450; Region: p450; cl12078
700508000329	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508000330	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000331	Methyltransferase domain; Region: Methyltransf_24; pfam13578
700508000332	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
700508000333	Protein of unknown function, DUF608; Region: DUF608; pfam04685
700508000334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508000335	S-adenosylmethionine binding site [chemical binding]; other site
700508000336	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508000337	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700508000338	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
700508000339	Isochorismatase family; Region: Isochorismatase; pfam00857
700508000340	catalytic triad [active]
700508000341	conserved cis-peptide bond; other site
700508000342	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
700508000343	helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422
700508000344	DNA binding residues [nucleotide binding]
700508000345	MerR, DNA binding; Region: MerR-DNA-bind; pfam09278
700508000346	high affinity sulphate transporter 1; Region: sulP; TIGR00815
700508000347	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
700508000348	Sulfate transporter family; Region: Sulfate_transp; pfam00916
700508000349	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
700508000350	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
700508000351	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508000352	Walker A/P-loop; other site
700508000353	ATP binding site [chemical binding]; other site
700508000354	Q-loop/lid; other site
700508000355	ABC transporter signature motif; other site
700508000356	Walker B; other site
700508000357	D-loop; other site
700508000358	H-loop/switch region; other site
700508000359	ABC-2 type transporter; Region: ABC2_membrane; cl17235
700508000360	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700508000361	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
700508000362	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
700508000363	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
700508000364	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
700508000365	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700508000366	active site
700508000367	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
700508000368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508000369	Walker A/P-loop; other site
700508000370	ATP binding site [chemical binding]; other site
700508000371	Q-loop/lid; other site
700508000372	ABC transporter signature motif; other site
700508000373	Walker B; other site
700508000374	D-loop; other site
700508000375	H-loop/switch region; other site
700508000376	TOBE domain; Region: TOBE_2; pfam08402
700508000377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508000378	dimer interface [polypeptide binding]; other site
700508000379	conserved gate region; other site
700508000380	putative PBP binding loops; other site
700508000381	ABC-ATPase subunit interface; other site
700508000382	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
700508000383	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
700508000384	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508000385	acyl-activating enzyme (AAE) consensus motif; other site
700508000386	AMP binding site [chemical binding]; other site
700508000387	active site
700508000388	CoA binding site [chemical binding]; other site
700508000389	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508000390	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
700508000391	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
700508000392	putative NAD(P) binding site [chemical binding]; other site
700508000393	active site
700508000394	putative substrate binding site [chemical binding]; other site
700508000395	PE-PPE domain; Region: PE-PPE; pfam08237
700508000396	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
700508000397	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
700508000398	iron-sulfur cluster [ion binding]; other site
700508000399	[2Fe-2S] cluster binding site [ion binding]; other site
700508000400	GtrA-like protein; Region: GtrA; pfam04138
700508000401	short chain dehydrogenase; Provisional; Region: PRK06197
700508000402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508000403	NAD(P) binding site [chemical binding]; other site
700508000404	active site
700508000405	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508000406	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508000407	metal binding site [ion binding]; metal-binding site
700508000408	active site
700508000409	I-site; other site
700508000410	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
700508000411	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
700508000412	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508000413	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
700508000414	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
700508000415	tetrameric interface [polypeptide binding]; other site
700508000416	NAD binding site [chemical binding]; other site
700508000417	catalytic residues [active]
700508000418	hypothetical protein; Provisional; Region: PRK06062
700508000419	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508000420	inhibitor-cofactor binding pocket; inhibition site
700508000421	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508000422	catalytic residue [active]
700508000423	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700508000424	active site
700508000425	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
700508000426	heme-binding site [chemical binding]; other site
700508000427	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508000428	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508000429	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
700508000430	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
700508000431	Walker A/P-loop; other site
700508000432	ATP binding site [chemical binding]; other site
700508000433	Q-loop/lid; other site
700508000434	ABC transporter signature motif; other site
700508000435	Walker B; other site
700508000436	D-loop; other site
700508000437	H-loop/switch region; other site
700508000438	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508000439	ABC-ATPase subunit interface; other site
700508000440	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
700508000441	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
700508000442	substrate binding pocket [chemical binding]; other site
700508000443	membrane-bound complex binding site; other site
700508000444	hypothetical protein; Validated; Region: PRK07121
700508000445	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
700508000446	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
700508000447	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
700508000448	dimer interface [polypeptide binding]; other site
700508000449	PYR/PP interface [polypeptide binding]; other site
700508000450	TPP binding site [chemical binding]; other site
700508000451	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
700508000452	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
700508000453	TPP-binding site [chemical binding]; other site
700508000454	dimer interface [polypeptide binding]; other site
700508000455	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
700508000456	putative hydrophobic ligand binding site [chemical binding]; other site
700508000457	protein interface [polypeptide binding]; other site
700508000458	gate; other site
700508000459	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508000460	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508000461	active site
700508000462	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508000463	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
700508000464	active site
700508000465	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
700508000466	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
700508000467	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
700508000468	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508000469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508000470	active site
700508000471	phosphorylation site [posttranslational modification]
700508000472	intermolecular recognition site; other site
700508000473	dimerization interface [polypeptide binding]; other site
700508000474	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508000475	DNA binding residues [nucleotide binding]
700508000476	dimerization interface [polypeptide binding]; other site
700508000477	Histidine kinase; Region: HisKA_3; pfam07730
700508000478	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
700508000479	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
700508000480	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508000481	MarR family; Region: MarR; pfam01047
700508000482	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
700508000483	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508000484	ATP binding site [chemical binding]; other site
700508000485	putative Mg++ binding site [ion binding]; other site
700508000486	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508000487	nucleotide binding region [chemical binding]; other site
700508000488	ATP-binding site [chemical binding]; other site
700508000489	Helicase associated domain (HA2); Region: HA2; pfam04408
700508000490	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
700508000491	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
700508000492	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508000493	ferredoxin-NADP+ reductase; Region: PLN02852
700508000494	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508000495	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
700508000496	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
700508000497	putative active site [active]
700508000498	metal binding site [ion binding]; metal-binding site
700508000499	GAF domain; Region: GAF; pfam01590
700508000500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508000501	acetoin reductases; Region: 23BDH; TIGR02415
700508000502	NAD(P) binding site [chemical binding]; other site
700508000503	active site
700508000504	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700508000505	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
700508000506	putative NAD(P) binding site [chemical binding]; other site
700508000507	catalytic Zn binding site [ion binding]; other site
700508000508	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508000509	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508000510	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508000511	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
700508000512	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508000513	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508000514	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508000515	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508000516	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000517	potassium/proton antiporter; Reviewed; Region: PRK05326
700508000518	TrkA-C domain; Region: TrkA_C; pfam02080
700508000519	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
700508000520	TrkA-N domain; Region: TrkA_N; pfam02254
700508000521	TrkA-C domain; Region: TrkA_C; pfam02080
700508000522	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508000523	ATP binding site [chemical binding]; other site
700508000524	putative Mg++ binding site [ion binding]; other site
700508000525	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508000526	nucleotide binding region [chemical binding]; other site
700508000527	ATP-binding site [chemical binding]; other site
700508000528	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
700508000529	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
700508000530	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700508000531	NAD binding site [chemical binding]; other site
700508000532	catalytic Zn binding site [ion binding]; other site
700508000533	structural Zn binding site [ion binding]; other site
700508000534	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
700508000535	putative catalytic site [active]
700508000536	putative metal binding site [ion binding]; other site
700508000537	putative phosphate binding site [ion binding]; other site
700508000538	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
700508000539	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
700508000540	active site
700508000541	DNA binding site [nucleotide binding]
700508000542	Int/Topo IB signature motif; other site
700508000543	short chain dehydrogenase; Provisional; Region: PRK06940
700508000544	classical (c) SDRs; Region: SDR_c; cd05233
700508000545	NAD(P) binding site [chemical binding]; other site
700508000546	active site
700508000547	von Willebrand factor type A domain; Region: VWA_2; pfam13519
700508000548	Protein of unknown function DUF58; Region: DUF58; pfam01882
700508000549	MoxR-like ATPases [General function prediction only]; Region: COG0714
700508000550	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508000551	ATP binding site [chemical binding]; other site
700508000552	Walker A motif; other site
700508000553	Walker B motif; other site
700508000554	arginine finger; other site
700508000555	Transmembrane secretion effector; Region: MFS_3; pfam05977
700508000556	GAF domain; Region: GAF; cl17456
700508000557	GAF domain; Region: GAF_2; pfam13185
700508000558	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
700508000559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508000560	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700508000561	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508000562	anti sigma factor interaction site; other site
700508000563	regulatory phosphorylation site [posttranslational modification]; other site
700508000564	AAA ATPase domain; Region: AAA_16; pfam13191
700508000565	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
700508000566	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508000567	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508000568	DNA binding residues [nucleotide binding]
700508000569	dimerization interface [polypeptide binding]; other site
700508000570	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
700508000571	putative FMN binding site [chemical binding]; other site
700508000572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508000573	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700508000574	NAD(P) binding site [chemical binding]; other site
700508000575	active site
700508000576	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508000577	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508000578	active site
700508000579	ATP binding site [chemical binding]; other site
700508000580	substrate binding site [chemical binding]; other site
700508000581	activation loop (A-loop); other site
700508000582	Cupin; Region: Cupin_6; pfam12852
700508000583	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508000584	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700508000585	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508000586	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508000587	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700508000588	NAD(P) binding site [chemical binding]; other site
700508000589	active site
700508000590	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
700508000591	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
700508000592	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508000593	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508000594	active site
700508000595	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
700508000596	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508000597	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508000598	DNA binding residues [nucleotide binding]
700508000599	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
700508000600	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
700508000601	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
700508000602	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508000603	Walker A/P-loop; other site
700508000604	ATP binding site [chemical binding]; other site
700508000605	Q-loop/lid; other site
700508000606	ABC transporter signature motif; other site
700508000607	Walker B; other site
700508000608	D-loop; other site
700508000609	H-loop/switch region; other site
700508000610	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700508000611	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
700508000612	active site
700508000613	catalytic site [active]
700508000614	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508000615	active site 2 [active]
700508000616	active site 1 [active]
700508000617	threonine dehydratase; Provisional; Region: PRK08198
700508000618	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
700508000619	tetramer interface [polypeptide binding]; other site
700508000620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508000621	catalytic residue [active]
700508000622	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
700508000623	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508000624	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508000625	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
700508000626	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000627	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
700508000628	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
700508000629	TrkA-N domain; Region: TrkA_N; pfam02254
700508000630	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
700508000631	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508000632	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508000633	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508000634	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000635	carboxylate-amine ligase; Provisional; Region: PRK13517
700508000636	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
700508000637	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
700508000638	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508000639	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508000640	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
700508000641	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
700508000642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508000643	Mg2+ binding site [ion binding]; other site
700508000644	G-X-G motif; other site
700508000645	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
700508000646	ATP binding site [chemical binding]; other site
700508000647	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
700508000648	active site
700508000649	metal binding site [ion binding]; metal-binding site
700508000650	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
700508000651	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
700508000652	CAP-like domain; other site
700508000653	DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521
700508000654	active site
700508000655	primary dimer interface [polypeptide binding]; other site
700508000656	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700508000657	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508000658	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700508000659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508000660	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700508000661	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700508000662	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508000663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508000664	phosphorylation site [posttranslational modification]
700508000665	dimer interface [polypeptide binding]; other site
700508000666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508000667	ATP binding site [chemical binding]; other site
700508000668	Mg2+ binding site [ion binding]; other site
700508000669	G-X-G motif; other site
700508000670	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508000671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508000672	active site
700508000673	phosphorylation site [posttranslational modification]
700508000674	intermolecular recognition site; other site
700508000675	dimerization interface [polypeptide binding]; other site
700508000676	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508000677	DNA binding site [nucleotide binding]
700508000678	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508000679	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
700508000680	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
700508000681	active site
700508000682	Zn binding site [ion binding]; other site
700508000683	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
700508000684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
700508000685	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700508000686	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700508000687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508000688	Domain of unknown function DUF77; Region: DUF77; pfam01910
700508000689	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
700508000690	putative homotetramer interface [polypeptide binding]; other site
700508000691	putative homodimer interface [polypeptide binding]; other site
700508000692	putative allosteric switch controlling residues; other site
700508000693	putative metal binding site [ion binding]; other site
700508000694	putative homodimer-homodimer interface [polypeptide binding]; other site
700508000695	Domain of unknown function (DUF305); Region: DUF305; pfam03713
700508000696	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
700508000697	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
700508000698	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
700508000699	active site
700508000700	TDP-binding site; other site
700508000701	acceptor substrate-binding pocket; other site
700508000702	homodimer interface [polypeptide binding]; other site
700508000703	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700508000704	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
700508000705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508000706	S-adenosylmethionine binding site [chemical binding]; other site
700508000707	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
700508000708	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
700508000709	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508000710	RNA polymerase factor sigma-70; Validated; Region: PRK08241
700508000711	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508000712	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
700508000713	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
700508000714	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
700508000715	dimer interface [polypeptide binding]; other site
700508000716	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
700508000717	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
700508000718	NAD binding site [chemical binding]; other site
700508000719	catalytic Zn binding site [ion binding]; other site
700508000720	substrate binding site [chemical binding]; other site
700508000721	structural Zn binding site [ion binding]; other site
700508000722	PE-PPE domain; Region: PE-PPE; pfam08237
700508000723	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700508000724	Sulfatase; Region: Sulfatase; pfam00884
700508000725	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508000726	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000727	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508000728	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700508000729	NAD(P) binding site [chemical binding]; other site
700508000730	active site
700508000731	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700508000732	MarR family; Region: MarR_2; pfam12802
700508000733	Pirin-related protein [General function prediction only]; Region: COG1741
700508000734	Pirin; Region: Pirin; pfam02678
700508000735	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
700508000736	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
700508000737	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
700508000738	PE-PPE domain; Region: PE-PPE; pfam08237
700508000739	short chain dehydrogenase; Provisional; Region: PRK06914
700508000740	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508000741	NAD(P) binding site [chemical binding]; other site
700508000742	active site
700508000743	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
700508000744	RDD family; Region: RDD; pfam06271
700508000745	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508000746	mce related protein; Region: MCE; pfam02470
700508000747	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508000748	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508000749	mce related protein; Region: MCE; pfam02470
700508000750	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
700508000751	mce related protein; Region: MCE; pfam02470
700508000752	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508000753	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508000754	mce related protein; Region: MCE; pfam02470
700508000755	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508000756	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508000757	mce related protein; Region: MCE; pfam02470
700508000758	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
700508000759	mce related protein; Region: MCE; pfam02470
700508000760	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508000761	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508000762	Permease; Region: Permease; pfam02405
700508000763	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508000764	Permease; Region: Permease; pfam02405
700508000765	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508000766	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508000767	DNA-binding site [nucleotide binding]; DNA binding site
700508000768	FCD domain; Region: FCD; pfam07729
700508000769	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
700508000770	putative hydrophobic ligand binding site [chemical binding]; other site
700508000771	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700508000772	active site
700508000773	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
700508000774	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700508000775	NAD(P) binding site [chemical binding]; other site
700508000776	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
700508000777	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
700508000778	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
700508000779	putative active site [active]
700508000780	putative active site [active]
700508000781	catalytic site [active]
700508000782	catalytic site [active]
700508000783	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
700508000784	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
700508000785	putative active site [active]
700508000786	putative active site [active]
700508000787	catalytic site [active]
700508000788	catalytic site [active]
700508000789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
700508000790	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
700508000791	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
700508000792	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508000793	active site
700508000794	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
700508000795	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
700508000796	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
700508000797	putative di-iron ligands [ion binding]; other site
700508000798	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
700508000799	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700508000800	FAD binding pocket [chemical binding]; other site
700508000801	FAD binding motif [chemical binding]; other site
700508000802	phosphate binding motif [ion binding]; other site
700508000803	beta-alpha-beta structure motif; other site
700508000804	NAD binding pocket [chemical binding]; other site
700508000805	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508000806	catalytic loop [active]
700508000807	iron binding site [ion binding]; other site
700508000808	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
700508000809	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508000810	NAD(P) binding site [chemical binding]; other site
700508000811	active site
700508000812	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508000813	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000814	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
700508000815	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
700508000816	Walker A/P-loop; other site
700508000817	ATP binding site [chemical binding]; other site
700508000818	Q-loop/lid; other site
700508000819	ABC transporter signature motif; other site
700508000820	Walker B; other site
700508000821	D-loop; other site
700508000822	H-loop/switch region; other site
700508000823	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
700508000824	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508000825	substrate binding pocket [chemical binding]; other site
700508000826	membrane-bound complex binding site; other site
700508000827	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
700508000828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508000829	ABC-ATPase subunit interface; other site
700508000830	putative PBP binding loops; other site
700508000831	Transcription elongation factor Elf1 like; Region: Elf1; cl02038
700508000832	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
700508000833	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
700508000834	oligomer interface [polypeptide binding]; other site
700508000835	metal binding site [ion binding]; metal-binding site
700508000836	metal binding site [ion binding]; metal-binding site
700508000837	putative Cl binding site [ion binding]; other site
700508000838	aspartate ring; other site
700508000839	basic sphincter; other site
700508000840	hydrophobic gate; other site
700508000841	periplasmic entrance; other site
700508000842	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
700508000843	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
700508000844	ligand binding site [chemical binding]; other site
700508000845	homodimer interface [polypeptide binding]; other site
700508000846	NAD(P) binding site [chemical binding]; other site
700508000847	trimer interface B [polypeptide binding]; other site
700508000848	trimer interface A [polypeptide binding]; other site
700508000849	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
700508000850	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
700508000851	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
700508000852	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508000853	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000854	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508000855	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508000856	active site
700508000857	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508000858	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508000859	active site
700508000860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508000861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508000862	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
700508000863	putative dimerization interface [polypeptide binding]; other site
700508000864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508000865	putative substrate translocation pore; other site
700508000866	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700508000867	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508000868	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508000869	active site
700508000870	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
700508000871	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
700508000872	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
700508000873	Protein of unknown function (DUF456); Region: DUF456; pfam04306
700508000874	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
700508000875	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
700508000876	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700508000877	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
700508000878	NAD(P) binding site [chemical binding]; other site
700508000879	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
700508000880	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
700508000881	homodimer interface [polypeptide binding]; other site
700508000882	NAD binding site [chemical binding]; other site
700508000883	active site
700508000884	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
700508000885	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
700508000886	NAD(P) binding site [chemical binding]; other site
700508000887	catalytic residues [active]
700508000888	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700508000889	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
700508000890	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508000891	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508000892	Pirin-related protein [General function prediction only]; Region: COG1741
700508000893	Pirin; Region: Pirin; pfam02678
700508000894	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
700508000895	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
700508000896	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
700508000897	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
700508000898	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
700508000899	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700508000900	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700508000901	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700508000902	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
700508000903	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
700508000904	putative substrate binding site [chemical binding]; other site
700508000905	putative ATP binding site [chemical binding]; other site
700508000906	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700508000907	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
700508000908	active site
700508000909	phosphorylation site [posttranslational modification]
700508000910	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
700508000911	active site
700508000912	P-loop; other site
700508000913	phosphorylation site [posttranslational modification]
700508000914	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
700508000915	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
700508000916	dimerization domain swap beta strand [polypeptide binding]; other site
700508000917	regulatory protein interface [polypeptide binding]; other site
700508000918	active site
700508000919	regulatory phosphorylation site [posttranslational modification]; other site
700508000920	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
700508000921	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
700508000922	active site
700508000923	catalytic residues [active]
700508000924	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
700508000925	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
700508000926	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
700508000927	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
700508000928	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700508000929	P-loop; other site
700508000930	Magnesium ion binding site [ion binding]; other site
700508000931	Proteins of 100 residues with WXG; Region: WXG100; cl02005
700508000932	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
700508000933	PPE family; Region: PPE; pfam00823
700508000934	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
700508000935	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
700508000936	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700508000937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508000938	Walker A motif; other site
700508000939	ATP binding site [chemical binding]; other site
700508000940	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
700508000941	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700508000942	Protein of unknown function (DUF690); Region: DUF690; cl04939
700508000943	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
700508000944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508000945	Walker A motif; other site
700508000946	ATP binding site [chemical binding]; other site
700508000947	Walker B motif; other site
700508000948	arginine finger; other site
700508000949	EspG family; Region: ESX-1_EspG; pfam14011
700508000950	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
700508000951	Transcription factor WhiB; Region: Whib; pfam02467
700508000952	Pirin-related protein [General function prediction only]; Region: COG1741
700508000953	Pirin; Region: Pirin; pfam02678
700508000954	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
700508000955	Predicted acetyltransferase [General function prediction only]; Region: COG2388
700508000956	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
700508000957	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508000958	CoenzymeA binding site [chemical binding]; other site
700508000959	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
700508000960	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
700508000961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
700508000962	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
700508000963	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
700508000964	heme binding site [chemical binding]; other site
700508000965	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
700508000966	ferric uptake regulator; Provisional; Region: fur; PRK09462
700508000967	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
700508000968	metal binding site 2 [ion binding]; metal-binding site
700508000969	putative DNA binding helix; other site
700508000970	metal binding site 1 [ion binding]; metal-binding site
700508000971	dimer interface [polypeptide binding]; other site
700508000972	structural Zn2+ binding site [ion binding]; other site
700508000973	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508000974	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508000975	substrate binding pocket [chemical binding]; other site
700508000976	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
700508000977	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508000978	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508000979	membrane-bound complex binding site; other site
700508000980	hinge residues; other site
700508000981	Secretory lipase; Region: LIP; pfam03583
700508000982	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508000983	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
700508000984	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508000985	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508000986	metal binding site [ion binding]; metal-binding site
700508000987	active site
700508000988	I-site; other site
700508000989	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
700508000990	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700508000991	Coenzyme A binding pocket [chemical binding]; other site
700508000992	CAAX protease self-immunity; Region: Abi; pfam02517
700508000993	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
700508000994	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700508000995	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700508000996	phosphopeptide binding site; other site
700508000997	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700508000998	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700508000999	phosphopeptide binding site; other site
700508001000	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
700508001001	active site
700508001002	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
700508001003	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
700508001004	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700508001005	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508001006	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508001007	active site
700508001008	ATP binding site [chemical binding]; other site
700508001009	substrate binding site [chemical binding]; other site
700508001010	activation loop (A-loop); other site
700508001011	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
700508001012	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508001013	active site
700508001014	ATP binding site [chemical binding]; other site
700508001015	substrate binding site [chemical binding]; other site
700508001016	activation loop (A-loop); other site
700508001017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
700508001018	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508001019	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508001020	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508001021	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508001022	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508001023	substrate binding pocket [chemical binding]; other site
700508001024	catalytic triad [active]
700508001025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
700508001026	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
700508001027	putative septation inhibitor protein; Reviewed; Region: PRK00159
700508001028	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
700508001029	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
700508001030	active site
700508001031	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
700508001032	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
700508001033	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700508001034	Sulfatase; Region: Sulfatase; pfam00884
700508001035	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
700508001036	DNA gyrase subunit A; Validated; Region: PRK05560
700508001037	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
700508001038	CAP-like domain; other site
700508001039	active site
700508001040	primary dimer interface [polypeptide binding]; other site
700508001041	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700508001042	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700508001043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700508001044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700508001045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700508001046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
700508001047	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
700508001048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508001049	Mg2+ binding site [ion binding]; other site
700508001050	G-X-G motif; other site
700508001051	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
700508001052	anchoring element; other site
700508001053	dimer interface [polypeptide binding]; other site
700508001054	ATP binding site [chemical binding]; other site
700508001055	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
700508001056	active site
700508001057	putative metal-binding site [ion binding]; other site
700508001058	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
700508001059	hypothetical protein; Provisional; Region: PRK03195
700508001060	recombination protein F; Reviewed; Region: recF; PRK00064
700508001061	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
700508001062	Walker A/P-loop; other site
700508001063	ATP binding site [chemical binding]; other site
700508001064	Q-loop/lid; other site
700508001065	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508001066	ABC transporter signature motif; other site
700508001067	Walker B; other site
700508001068	D-loop; other site
700508001069	H-loop/switch region; other site
700508001070	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700508001071	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
700508001072	DNA polymerase III subunit beta; Validated; Region: PRK07761
700508001073	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
700508001074	putative DNA binding surface [nucleotide binding]; other site
700508001075	dimer interface [polypeptide binding]; other site
700508001076	beta-clamp/clamp loader binding surface; other site
700508001077	beta-clamp/translesion DNA polymerase binding surface; other site
700508001078	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
700508001079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508001080	Walker A motif; other site
700508001081	ATP binding site [chemical binding]; other site
700508001082	Walker B motif; other site
700508001083	arginine finger; other site
700508001084	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
700508001085	DnaA box-binding interface [nucleotide binding]; other site
700508001086	Ribonuclease P; Region: Ribonuclease_P; cl00457
700508001087	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
700508001088	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
700508001089	G-X-X-G motif; other site
700508001090	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
700508001091	RxxxH motif; other site
700508001092	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
700508001093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508001094	S-adenosylmethionine binding site [chemical binding]; other site
700508001095	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
700508001096	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700508001097	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700508001098	Magnesium ion binding site [ion binding]; other site
700508001099	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700508001100	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
700508001101	ParB-like nuclease domain; Region: ParBc; pfam02195
700508001102	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
700508001103	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
700508001104	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
700508001105	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
700508001106	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
700508001107	active site
700508001108	metal binding site [ion binding]; metal-binding site
700508001109	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700508001110	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700508001111	catalytic residues [active]
700508001112	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
700508001113	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508001114	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508001115	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
700508001116	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508001117	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508001118	DNA binding residues [nucleotide binding]
700508001119	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
700508001120	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
700508001121	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
700508001122	active site
700508001123	Ap6A binding site [chemical binding]; other site
700508001124	nudix motif; other site
700508001125	metal binding site [ion binding]; metal-binding site
700508001126	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
700508001127	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
700508001128	active site
700508001129	NTP binding site [chemical binding]; other site
700508001130	metal binding triad [ion binding]; metal-binding site
700508001131	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
700508001132	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700508001133	Zn2+ binding site [ion binding]; other site
700508001134	Mg2+ binding site [ion binding]; other site
700508001135	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
700508001136	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
700508001137	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
700508001138	TIGR03084 family protein; Region: TIGR03084
700508001139	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
700508001140	Wyosine base formation; Region: Wyosine_form; pfam08608
700508001141	H+ Antiporter protein; Region: 2A0121; TIGR00900
700508001142	hypothetical protein; Validated; Region: PRK00228
700508001143	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
700508001144	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
700508001145	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700508001146	active site
700508001147	HIGH motif; other site
700508001148	nucleotide binding site [chemical binding]; other site
700508001149	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
700508001150	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700508001151	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700508001152	active site
700508001153	KMSKS motif; other site
700508001154	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
700508001155	tRNA binding surface [nucleotide binding]; other site
700508001156	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
700508001157	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
700508001158	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
700508001159	NAD binding site [chemical binding]; other site
700508001160	catalytic Zn binding site [ion binding]; other site
700508001161	structural Zn binding site [ion binding]; other site
700508001162	short chain dehydrogenase; Provisional; Region: PRK08219
700508001163	classical (c) SDRs; Region: SDR_c; cd05233
700508001164	NAD(P) binding site [chemical binding]; other site
700508001165	active site
700508001166	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
700508001167	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508001168	MarR family; Region: MarR; pfam01047
700508001169	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700508001170	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700508001171	Walker A/P-loop; other site
700508001172	ATP binding site [chemical binding]; other site
700508001173	Q-loop/lid; other site
700508001174	ABC transporter signature motif; other site
700508001175	Walker B; other site
700508001176	D-loop; other site
700508001177	H-loop/switch region; other site
700508001178	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508001179	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508001180	substrate binding pocket [chemical binding]; other site
700508001181	membrane-bound complex binding site; other site
700508001182	hinge residues; other site
700508001183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508001184	dimer interface [polypeptide binding]; other site
700508001185	conserved gate region; other site
700508001186	putative PBP binding loops; other site
700508001187	ABC-ATPase subunit interface; other site
700508001188	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
700508001189	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508001190	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508001191	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
700508001192	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508001193	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
700508001194	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
700508001195	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
700508001196	Predicted transcriptional regulators [Transcription]; Region: COG1695
700508001197	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
700508001198	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
700508001199	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
700508001200	Transglycosylase; Region: Transgly; pfam00912
700508001201	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
700508001202	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700508001203	Predicted integral membrane protein [Function unknown]; Region: COG5650
700508001204	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
700508001205	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
700508001206	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
700508001207	dimer interface [polypeptide binding]; other site
700508001208	ssDNA binding site [nucleotide binding]; other site
700508001209	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700508001210	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
700508001211	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
700508001212	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
700508001213	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
700508001214	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
700508001215	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
700508001216	ATP binding site [chemical binding]; other site
700508001217	Walker B motif; other site
700508001218	DNA binding loops [nucleotide binding]
700508001219	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
700508001220	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
700508001221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
700508001222	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508001223	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001225	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
700508001226	benzoate transporter; Region: benE; TIGR00843
700508001227	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508001228	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508001229	non-specific DNA binding site [nucleotide binding]; other site
700508001230	salt bridge; other site
700508001231	sequence-specific DNA binding site [nucleotide binding]; other site
700508001232	Cupin domain; Region: Cupin_2; cl17218
700508001233	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001234	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001235	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
700508001236	active site
700508001237	metal binding site [ion binding]; metal-binding site
700508001238	The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257
700508001239	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508001240	putative active site [active]
700508001241	putative metal binding site [ion binding]; other site
700508001242	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
700508001243	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
700508001244	AMP-binding domain protein; Validated; Region: PRK07529
700508001245	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508001246	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508001247	acyl-activating enzyme (AAE) consensus motif; other site
700508001248	acyl-activating enzyme (AAE) consensus motif; other site
700508001249	AMP binding site [chemical binding]; other site
700508001250	active site
700508001251	CoA binding site [chemical binding]; other site
700508001252	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
700508001253	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508001254	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508001255	Cytochrome P450; Region: p450; cl12078
700508001256	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
700508001257	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
700508001258	active site pocket [active]
700508001259	oxyanion hole [active]
700508001260	catalytic triad [active]
700508001261	active site nucleophile [active]
700508001262	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508001263	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508001264	diaminopimelate decarboxylase; Region: lysA; TIGR01048
700508001265	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
700508001266	active site
700508001267	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700508001268	substrate binding site [chemical binding]; other site
700508001269	catalytic residues [active]
700508001270	dimer interface [polypeptide binding]; other site
700508001271	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
700508001272	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700508001273	nucleotide binding site [chemical binding]; other site
700508001274	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
700508001275	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508001276	inhibitor-cofactor binding pocket; inhibition site
700508001277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508001278	catalytic residue [active]
700508001279	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294
700508001280	interface (dimer of trimers) [polypeptide binding]; other site
700508001281	Substrate-binding/catalytic site; other site
700508001282	Zn-binding sites [ion binding]; other site
700508001283	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
700508001284	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
700508001285	peptide binding site [polypeptide binding]; other site
700508001286	dimer interface [polypeptide binding]; other site
700508001287	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700508001288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508001289	dimer interface [polypeptide binding]; other site
700508001290	conserved gate region; other site
700508001291	putative PBP binding loops; other site
700508001292	ABC-ATPase subunit interface; other site
700508001293	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
700508001294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508001295	dimer interface [polypeptide binding]; other site
700508001296	conserved gate region; other site
700508001297	putative PBP binding loops; other site
700508001298	ABC-ATPase subunit interface; other site
700508001299	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
700508001300	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508001301	Walker A/P-loop; other site
700508001302	ATP binding site [chemical binding]; other site
700508001303	Q-loop/lid; other site
700508001304	ABC transporter signature motif; other site
700508001305	Walker B; other site
700508001306	D-loop; other site
700508001307	H-loop/switch region; other site
700508001308	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
700508001309	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508001310	Walker A/P-loop; other site
700508001311	ATP binding site [chemical binding]; other site
700508001312	Q-loop/lid; other site
700508001313	ABC transporter signature motif; other site
700508001314	Walker B; other site
700508001315	D-loop; other site
700508001316	H-loop/switch region; other site
700508001317	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
700508001318	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700508001319	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508001320	DNA-binding site [nucleotide binding]; DNA binding site
700508001321	UTRA domain; Region: UTRA; pfam07702
700508001322	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
700508001323	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
700508001324	active site
700508001325	trimer interface [polypeptide binding]; other site
700508001326	allosteric site; other site
700508001327	active site lid [active]
700508001328	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700508001329	Proteins of 100 residues with WXG; Region: WXG100; cl02005
700508001330	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
700508001331	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508001332	putative substrate translocation pore; other site
700508001333	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
700508001334	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
700508001335	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
700508001336	DJ-1 family protein; Region: not_thiJ; TIGR01383
700508001337	conserved cys residue [active]
700508001338	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
700508001339	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
700508001340	conserved cys residue [active]
700508001341	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508001342	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508001343	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
700508001344	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
700508001345	conserved cys residue [active]
700508001346	haloalkane dehalogenase; Provisional; Region: PRK03592
700508001347	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
700508001348	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
700508001349	active site
700508001350	TDP-binding site; other site
700508001351	acceptor substrate-binding pocket; other site
700508001352	homodimer interface [polypeptide binding]; other site
700508001353	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001354	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001355	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508001356	Coenzyme A binding pocket [chemical binding]; other site
700508001357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508001358	C factor cell-cell signaling protein; Provisional; Region: PRK09009
700508001359	NAD(P) binding site [chemical binding]; other site
700508001360	active site
700508001361	classical (c) SDRs; Region: SDR_c; cd05233
700508001362	short chain dehydrogenase; Provisional; Region: PRK05650
700508001363	NAD(P) binding site [chemical binding]; other site
700508001364	active site
700508001365	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
700508001366	dinuclear metal binding motif [ion binding]; other site
700508001367	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508001368	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508001369	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
700508001370	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508001371	DNA binding residues [nucleotide binding]
700508001372	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
700508001373	MgtC family; Region: MgtC; pfam02308
700508001374	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
700508001375	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
700508001376	ligand binding site [chemical binding]; other site
700508001377	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700508001378	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700508001379	TM-ABC transporter signature motif; other site
700508001380	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700508001381	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508001382	Walker A/P-loop; other site
700508001383	ATP binding site [chemical binding]; other site
700508001384	Q-loop/lid; other site
700508001385	ABC transporter signature motif; other site
700508001386	Walker B; other site
700508001387	D-loop; other site
700508001388	H-loop/switch region; other site
700508001389	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
700508001390	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700508001391	substrate binding site [chemical binding]; other site
700508001392	ATP binding site [chemical binding]; other site
700508001393	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
700508001394	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
700508001395	active site
700508001396	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700508001397	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700508001398	DNA binding site [nucleotide binding]
700508001399	domain linker motif; other site
700508001400	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700508001401	dimerization interface [polypeptide binding]; other site
700508001402	ligand binding site [chemical binding]; other site
700508001403	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
700508001404	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
700508001405	lycopene cyclase; Region: lycopene_cycl; TIGR01789
700508001406	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
700508001407	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
700508001408	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
700508001409	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
700508001410	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700508001411	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700508001412	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508001413	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508001414	active site
700508001415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
700508001416	Transposase; Region: DDE_Tnp_ISL3; pfam01610
700508001417	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
700508001418	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
700508001419	Peptidase family M23; Region: Peptidase_M23; pfam01551
700508001420	Predicted integral membrane protein [Function unknown]; Region: COG0392
700508001421	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
700508001422	Domain of unknown function DUF20; Region: UPF0118; pfam01594
700508001423	MMPL family; Region: MMPL; pfam03176
700508001424	MMPL family; Region: MMPL; pfam03176
700508001425	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
700508001426	LabA_like proteins; Region: LabA_like; cd06167
700508001427	putative metal binding site [ion binding]; other site
700508001428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508001429	S-adenosylmethionine binding site [chemical binding]; other site
700508001430	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
700508001431	active site
700508001432	substrate-binding site [chemical binding]; other site
700508001433	metal-binding site [ion binding]
700508001434	GTP binding site [chemical binding]; other site
700508001435	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700508001436	hydrophobic ligand binding site; other site
700508001437	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700508001438	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
700508001439	putative NAD(P) binding site [chemical binding]; other site
700508001440	putative active site [active]
700508001441	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508001442	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
700508001443	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
700508001444	acyl-activating enzyme (AAE) consensus motif; other site
700508001445	putative AMP binding site [chemical binding]; other site
700508001446	putative active site [active]
700508001447	putative CoA binding site [chemical binding]; other site
700508001448	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
700508001449	classical (c) SDRs; Region: SDR_c; cd05233
700508001450	NAD(P) binding site [chemical binding]; other site
700508001451	active site
700508001452	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508001453	salt bridge; other site
700508001454	non-specific DNA binding site [nucleotide binding]; other site
700508001455	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508001456	sequence-specific DNA binding site [nucleotide binding]; other site
700508001457	H+ Antiporter protein; Region: 2A0121; TIGR00900
700508001458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508001459	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508001460	dimerization interface [polypeptide binding]; other site
700508001461	putative DNA binding site [nucleotide binding]; other site
700508001462	putative Zn2+ binding site [ion binding]; other site
700508001463	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508001464	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508001465	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
700508001466	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508001467	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508001468	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508001469	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508001470	active site
700508001471	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508001472	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508001473	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508001474	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508001475	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
700508001476	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
700508001477	acyl-CoA synthetase; Provisional; Region: PRK13382
700508001478	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508001479	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
700508001480	acyl-activating enzyme (AAE) consensus motif; other site
700508001481	acyl-activating enzyme (AAE) consensus motif; other site
700508001482	putative AMP binding site [chemical binding]; other site
700508001483	putative active site [active]
700508001484	putative CoA binding site [chemical binding]; other site
700508001485	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700508001486	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
700508001487	putative acyl-acceptor binding pocket; other site
700508001488	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
700508001489	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508001490	active site
700508001491	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508001492	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508001493	active site
700508001494	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700508001495	DinB superfamily; Region: DinB_2; pfam12867
700508001496	RibD C-terminal domain; Region: RibD_C; cl17279
700508001497	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
700508001498	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
700508001499	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
700508001500	FAD binding site [chemical binding]; other site
700508001501	substrate binding site [chemical binding]; other site
700508001502	catalytic residues [active]
700508001503	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
700508001504	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
700508001505	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508001506	NAD binding site [chemical binding]; other site
700508001507	catalytic residues [active]
700508001508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508001509	S-adenosylmethionine binding site [chemical binding]; other site
700508001510	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700508001511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508001512	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
700508001513	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700508001514	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
700508001515	active site
700508001516	substrate binding pocket [chemical binding]; other site
700508001517	homodimer interaction site [polypeptide binding]; other site
700508001518	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
700508001519	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
700508001520	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700508001521	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
700508001522	FMN-binding pocket [chemical binding]; other site
700508001523	flavin binding motif; other site
700508001524	phosphate binding motif [ion binding]; other site
700508001525	beta-alpha-beta structure motif; other site
700508001526	NAD binding pocket [chemical binding]; other site
700508001527	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508001528	catalytic loop [active]
700508001529	iron binding site [ion binding]; other site
700508001530	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001531	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001532	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508001533	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508001534	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508001535	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
700508001536	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
700508001537	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
700508001538	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
700508001539	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
700508001540	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001541	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001542	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508001543	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508001544	active site 2 [active]
700508001545	active site 1 [active]
700508001546	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
700508001547	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508001548	NAD(P) binding site [chemical binding]; other site
700508001549	active site
700508001550	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
700508001551	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508001552	dimer interface [polypeptide binding]; other site
700508001553	active site
700508001554	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
700508001555	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
700508001556	gating phenylalanine in ion channel; other site
700508001557	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
700508001558	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508001559	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508001560	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508001561	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508001562	non-specific DNA binding site [nucleotide binding]; other site
700508001563	salt bridge; other site
700508001564	sequence-specific DNA binding site [nucleotide binding]; other site
700508001565	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
700508001566	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
700508001567	oligomer interface [polypeptide binding]; other site
700508001568	active site residues [active]
700508001569	Clp protease; Region: CLP_protease; pfam00574
700508001570	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
700508001571	oligomer interface [polypeptide binding]; other site
700508001572	active site residues [active]
700508001573	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
700508001574	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
700508001575	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
700508001576	FAD binding site [chemical binding]; other site
700508001577	substrate binding site [chemical binding]; other site
700508001578	catalytic residues [active]
700508001579	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
700508001580	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
700508001581	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700508001582	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
700508001583	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
700508001584	active site
700508001585	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
700508001586	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
700508001587	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
700508001588	NADP binding site [chemical binding]; other site
700508001589	active site
700508001590	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
700508001591	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
700508001592	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
700508001593	active site
700508001594	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
700508001595	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
700508001596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508001597	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
700508001598	Enoylreductase; Region: PKS_ER; smart00829
700508001599	NAD(P) binding site [chemical binding]; other site
700508001600	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
700508001601	putative NADP binding site [chemical binding]; other site
700508001602	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
700508001603	active site
700508001604	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
700508001605	Condensation domain; Region: Condensation; pfam00668
700508001606	Transport protein; Region: actII; TIGR00833
700508001607	PE-PPE domain; Region: PE-PPE; pfam08237
700508001608	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
700508001609	acyl-CoA synthetase; Validated; Region: PRK05850
700508001610	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
700508001611	acyl-activating enzyme (AAE) consensus motif; other site
700508001612	active site
700508001613	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
700508001614	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
700508001615	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508001616	catalytic loop [active]
700508001617	iron binding site [ion binding]; other site
700508001618	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
700508001619	L-aspartate oxidase; Provisional; Region: PRK06175
700508001620	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
700508001621	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
700508001622	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
700508001623	tetramer interface [polypeptide binding]; other site
700508001624	active site
700508001625	Mg2+/Mn2+ binding site [ion binding]; other site
700508001626	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700508001627	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700508001628	putative dimer interface [polypeptide binding]; other site
700508001629	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
700508001630	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508001631	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
700508001632	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
700508001633	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
700508001634	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
700508001635	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
700508001636	putative active site [active]
700508001637	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
700508001638	putative active site [active]
700508001639	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
700508001640	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
700508001641	active site
700508001642	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
700508001643	DNA binding site [nucleotide binding]
700508001644	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508001645	Coenzyme A binding pocket [chemical binding]; other site
700508001646	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
700508001647	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
700508001648	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
700508001649	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
700508001650	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
700508001651	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
700508001652	intersubunit interface [polypeptide binding]; other site
700508001653	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
700508001654	DNA-binding interface [nucleotide binding]; DNA binding site
700508001655	tetracycline repressor protein TetR; Provisional; Region: PRK13756
700508001656	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
700508001657	Predicted amidohydrolase [General function prediction only]; Region: COG0388
700508001658	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
700508001659	active site
700508001660	catalytic triad [active]
700508001661	dimer interface [polypeptide binding]; other site
700508001662	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
700508001663	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
700508001664	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
700508001665	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508001666	MarR family; Region: MarR; pfam01047
700508001667	hypothetical protein; Provisional; Region: PRK06184
700508001668	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508001669	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700508001670	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700508001671	NAD(P) binding site [chemical binding]; other site
700508001672	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508001673	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508001674	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001676	Ferredoxin [Energy production and conversion]; Region: COG1146
700508001677	4Fe-4S binding domain; Region: Fer4; pfam00037
700508001678	ferredoxin-NADP+ reductase; Region: PLN02852
700508001679	acyl-CoA synthetase; Validated; Region: PRK07798
700508001680	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508001681	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508001682	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
700508001683	acyl-activating enzyme (AAE) consensus motif; other site
700508001684	acyl-activating enzyme (AAE) consensus motif; other site
700508001685	putative AMP binding site [chemical binding]; other site
700508001686	putative active site [active]
700508001687	putative CoA binding site [chemical binding]; other site
700508001688	Phosphotransferase enzyme family; Region: APH; pfam01636
700508001689	Ecdysteroid kinase; Region: EcKinase; cl17738
700508001690	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508001691	Emopamil binding protein; Region: EBP; pfam05241
700508001692	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508001693	mce related protein; Region: MCE; pfam02470
700508001694	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508001695	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508001696	mce related protein; Region: MCE; pfam02470
700508001697	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508001698	mce related protein; Region: MCE; pfam02470
700508001699	mce related protein; Region: MCE; pfam02470
700508001700	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508001701	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508001702	mce related protein; Region: MCE; pfam02470
700508001703	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508001704	mce related protein; Region: MCE; pfam02470
700508001705	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001706	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001707	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
700508001708	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001709	hypothetical protein; Provisional; Region: PRK07236
700508001710	hypothetical protein; Provisional; Region: PRK07588
700508001711	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
700508001712	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508001713	MarR family; Region: MarR_2; pfam12802
700508001714	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
700508001715	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508001716	NAD(P) binding site [chemical binding]; other site
700508001717	active site
700508001718	Amino acid permease; Region: AA_permease; pfam00324
700508001719	Protein of unknown function (DUF692); Region: DUF692; cl01263
700508001720	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
700508001721	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508001722	inhibitor-cofactor binding pocket; inhibition site
700508001723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508001724	catalytic residue [active]
700508001725	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
700508001726	NAD(P) binding site [chemical binding]; other site
700508001727	catalytic residues [active]
700508001728	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
700508001729	Hexamer interface [polypeptide binding]; other site
700508001730	Hexagonal pore residue; other site
700508001731	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
700508001732	putative hexamer interface [polypeptide binding]; other site
700508001733	putative hexagonal pore; other site
700508001734	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
700508001735	Hexamer/Pentamer interface [polypeptide binding]; other site
700508001736	central pore; other site
700508001737	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
700508001738	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
700508001739	Hexamer interface [polypeptide binding]; other site
700508001740	Hexagonal pore residue; other site
700508001741	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
700508001742	putative hexamer interface [polypeptide binding]; other site
700508001743	putative hexagonal pore; other site
700508001744	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
700508001745	Hexamer interface [polypeptide binding]; other site
700508001746	Hexagonal pore residue; other site
700508001747	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508001748	active site
700508001749	substrate binding site [chemical binding]; other site
700508001750	Phosphotransferase enzyme family; Region: APH; pfam01636
700508001751	ATP binding site [chemical binding]; other site
700508001752	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
700508001753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508001754	NAD(P) binding site [chemical binding]; other site
700508001755	active site
700508001756	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508001757	DNA-binding site [nucleotide binding]; DNA binding site
700508001758	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700508001759	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
700508001760	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700508001761	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700508001762	non-specific DNA interactions [nucleotide binding]; other site
700508001763	DNA binding site [nucleotide binding]
700508001764	sequence specific DNA binding site [nucleotide binding]; other site
700508001765	putative cAMP binding site [chemical binding]; other site
700508001766	TspO/MBR family; Region: TspO_MBR; pfam03073
700508001767	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
700508001768	active site
700508001769	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
700508001770	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
700508001771	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
700508001772	homodimer interface [polypeptide binding]; other site
700508001773	active site
700508001774	TDP-binding site; other site
700508001775	acceptor substrate-binding pocket; other site
700508001776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001777	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001778	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
700508001779	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
700508001780	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
700508001781	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
700508001782	NAD(P) binding site [chemical binding]; other site
700508001783	catalytic residues [active]
700508001784	Amino acid permease; Region: AA_permease_2; pfam13520
700508001785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
700508001786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508001787	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508001788	putative substrate translocation pore; other site
700508001789	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700508001790	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
700508001791	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
700508001792	metal binding site [ion binding]; metal-binding site
700508001793	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
700508001794	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
700508001795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700508001796	PAS domain; Region: PAS_9; pfam13426
700508001797	putative active site [active]
700508001798	heme pocket [chemical binding]; other site
700508001799	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
700508001800	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
700508001801	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508001802	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
700508001803	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
700508001804	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
700508001805	active site
700508001806	catalytic site [active]
700508001807	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700508001808	Uncharacterized conserved protein [Function unknown]; Region: COG1262
700508001809	Lysine efflux permease [General function prediction only]; Region: COG1279
700508001810	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
700508001811	Transposase; Region: DDE_Tnp_ISL3; pfam01610
700508001812	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508001813	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508001814	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
700508001815	putative dimerization interface [polypeptide binding]; other site
700508001816	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508001817	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508001818	DNA-binding site [nucleotide binding]; DNA binding site
700508001819	FCD domain; Region: FCD; pfam07729
700508001820	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
700508001821	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700508001822	PYR/PP interface [polypeptide binding]; other site
700508001823	dimer interface [polypeptide binding]; other site
700508001824	TPP binding site [chemical binding]; other site
700508001825	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700508001826	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
700508001827	TPP-binding site [chemical binding]; other site
700508001828	dimer interface [polypeptide binding]; other site
700508001829	metabolite-proton symporter; Region: 2A0106; TIGR00883
700508001830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508001831	putative substrate translocation pore; other site
700508001832	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
700508001833	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508001834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508001835	NAD(P) binding site [chemical binding]; other site
700508001836	active site
700508001837	dihydroxyacetone kinase; Provisional; Region: PRK14479
700508001838	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
700508001839	DAK2 domain; Region: Dak2; pfam02734
700508001840	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
700508001841	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
700508001842	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
700508001843	Putative transcription activator [Transcription]; Region: TenA; COG0819
700508001844	intracellular protease, PfpI family; Region: PfpI; TIGR01382
700508001845	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
700508001846	proposed catalytic triad [active]
700508001847	conserved cys residue [active]
700508001848	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508001849	classical (c) SDRs; Region: SDR_c; cd05233
700508001850	NAD(P) binding site [chemical binding]; other site
700508001851	active site
700508001852	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
700508001853	MarR family; Region: MarR_2; cl17246
700508001854	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700508001855	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
700508001856	putative ligand binding site [chemical binding]; other site
700508001857	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
700508001858	acylamide amidohydrolase; Provisional; Region: amiE; PRK13286
700508001859	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
700508001860	multimer interface [polypeptide binding]; other site
700508001861	active site
700508001862	catalytic triad [active]
700508001863	dimer interface [polypeptide binding]; other site
700508001864	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
700508001865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508001866	Walker A motif; other site
700508001867	ATP binding site [chemical binding]; other site
700508001868	Walker B motif; other site
700508001869	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
700508001870	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
700508001871	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
700508001872	active site
700508001873	substrate binding site [chemical binding]; other site
700508001874	FMN binding site [chemical binding]; other site
700508001875	putative catalytic residues [active]
700508001876	Domain of unknown function (DUF385); Region: DUF385; pfam04075
700508001877	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
700508001878	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
700508001879	active site residue [active]
700508001880	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
700508001881	active site residue [active]
700508001882	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508001883	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508001884	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
700508001885	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
700508001886	active site
700508001887	non-prolyl cis peptide bond; other site
700508001888	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
700508001889	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508001890	active site
700508001891	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
700508001892	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
700508001893	putative active site [active]
700508001894	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
700508001895	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
700508001896	ligand binding site [chemical binding]; other site
700508001897	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
700508001898	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508001899	Walker A/P-loop; other site
700508001900	ATP binding site [chemical binding]; other site
700508001901	Q-loop/lid; other site
700508001902	ABC transporter signature motif; other site
700508001903	Walker B; other site
700508001904	D-loop; other site
700508001905	H-loop/switch region; other site
700508001906	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
700508001907	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700508001908	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700508001909	TM-ABC transporter signature motif; other site
700508001910	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
700508001911	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
700508001912	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508001913	active site 2 [active]
700508001914	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700508001915	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
700508001916	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
700508001917	Predicted amidohydrolase [General function prediction only]; Region: COG0388
700508001918	active site
700508001919	catalytic triad [active]
700508001920	dimer interface [polypeptide binding]; other site
700508001921	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508001922	Coenzyme A binding pocket [chemical binding]; other site
700508001923	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
700508001924	AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050
700508001925	dimerization interface [polypeptide binding]; other site
700508001926	putative ATP binding site [chemical binding]; other site
700508001927	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
700508001928	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508001929	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
700508001930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508001931	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
700508001932	Predicted amidohydrolase [General function prediction only]; Region: COG0388
700508001933	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
700508001934	active site
700508001935	catalytic triad [active]
700508001936	dimer interface [polypeptide binding]; other site
700508001937	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
700508001938	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
700508001939	dimer interface [polypeptide binding]; other site
700508001940	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508001941	anti sigma factor interaction site; other site
700508001942	regulatory phosphorylation site [posttranslational modification]; other site
700508001943	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
700508001944	nucleotide binding site [chemical binding]; other site
700508001945	acyl-CoA synthetase; Validated; Region: PRK07788
700508001946	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508001947	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508001948	active site
700508001949	CoA binding site [chemical binding]; other site
700508001950	AMP binding site [chemical binding]; other site
700508001951	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508001952	classical (c) SDRs; Region: SDR_c; cd05233
700508001953	NAD(P) binding site [chemical binding]; other site
700508001954	active site
700508001955	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508001956	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508001957	active site
700508001958	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508001959	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508001960	active site
700508001961	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
700508001962	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175
700508001963	putative ligand binding site [chemical binding]; other site
700508001964	putative NAD binding site [chemical binding]; other site
700508001965	catalytic site [active]
700508001966	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
700508001967	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001968	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001969	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
700508001970	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508001971	Zn binding site [ion binding]; other site
700508001972	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508001973	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508001974	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
700508001975	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
700508001976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508001977	Walker A motif; other site
700508001978	ATP binding site [chemical binding]; other site
700508001979	Walker B motif; other site
700508001980	arginine finger; other site
700508001981	Protein of unknown function (DUF690); Region: DUF690; cl04939
700508001982	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
700508001983	FliP family; Region: FliP; cl00593
700508001984	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700508001985	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
700508001986	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700508001987	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
700508001988	PPE family; Region: PPE; pfam00823
700508001989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
700508001990	EspG family; Region: ESX-1_EspG; pfam14011
700508001991	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
700508001992	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
700508001993	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
700508001994	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
700508001995	active site
700508001996	catalytic residues [active]
700508001997	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
700508001998	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508001999	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508002000	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
700508002001	active site
700508002002	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
700508002003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508002004	S-adenosylmethionine binding site [chemical binding]; other site
700508002005	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
700508002006	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
700508002007	CysD dimerization site [polypeptide binding]; other site
700508002008	G1 box; other site
700508002009	putative GEF interaction site [polypeptide binding]; other site
700508002010	GTP/Mg2+ binding site [chemical binding]; other site
700508002011	Switch I region; other site
700508002012	G2 box; other site
700508002013	G3 box; other site
700508002014	Switch II region; other site
700508002015	G4 box; other site
700508002016	G5 box; other site
700508002017	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
700508002018	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
700508002019	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
700508002020	ligand-binding site [chemical binding]; other site
700508002021	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
700508002022	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
700508002023	Active Sites [active]
700508002024	Stf0 sulphotransferase; Region: Sulphotransf; pfam09037
700508002025	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700508002026	Sulfatase; Region: Sulfatase; pfam00884
700508002027	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
700508002028	putative active site [active]
700508002029	putative CoA binding site [chemical binding]; other site
700508002030	nudix motif; other site
700508002031	metal binding site [ion binding]; metal-binding site
700508002032	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700508002033	active site
700508002034	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
700508002035	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
700508002036	active site
700508002037	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
700508002038	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
700508002039	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
700508002040	SnoaL-like domain; Region: SnoaL_3; pfam13474
700508002041	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
700508002042	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700508002043	nucleotide binding site [chemical binding]; other site
700508002044	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508002045	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508002046	non-specific DNA binding site [nucleotide binding]; other site
700508002047	salt bridge; other site
700508002048	sequence-specific DNA binding site [nucleotide binding]; other site
700508002049	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
700508002050	Domain of unknown function (DUF955); Region: DUF955; pfam06114
700508002051	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
700508002052	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
700508002053	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
700508002054	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
700508002055	tetramer interface [polypeptide binding]; other site
700508002056	active site
700508002057	Mg2+/Mn2+ binding site [ion binding]; other site
700508002058	citrate synthase; Provisional; Region: PRK14033
700508002059	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
700508002060	dimer interface [polypeptide binding]; other site
700508002061	active site
700508002062	citrylCoA binding site [chemical binding]; other site
700508002063	oxalacetate/citrate binding site [chemical binding]; other site
700508002064	coenzyme A binding site [chemical binding]; other site
700508002065	catalytic triad [active]
700508002066	pyruvate carboxylase; Reviewed; Region: PRK12999
700508002067	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700508002068	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508002069	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
700508002070	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
700508002071	active site
700508002072	catalytic residues [active]
700508002073	metal binding site [ion binding]; metal-binding site
700508002074	homodimer binding site [polypeptide binding]; other site
700508002075	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700508002076	carboxyltransferase (CT) interaction site; other site
700508002077	biotinylation site [posttranslational modification]; other site
700508002078	dihydropteroate synthase; Region: DHPS; TIGR01496
700508002079	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
700508002080	substrate binding pocket [chemical binding]; other site
700508002081	dimer interface [polypeptide binding]; other site
700508002082	inhibitor binding site; inhibition site
700508002083	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
700508002084	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
700508002085	THF binding site; other site
700508002086	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
700508002087	substrate binding site [chemical binding]; other site
700508002088	THF binding site; other site
700508002089	zinc-binding site [ion binding]; other site
700508002090	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
700508002091	active site
700508002092	catalytic residues [active]
700508002093	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
700508002094	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700508002095	putative methyltransferase; Provisional; Region: PRK14967
700508002096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508002097	S-adenosylmethionine binding site [chemical binding]; other site
700508002098	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
700508002099	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
700508002100	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
700508002101	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
700508002102	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
700508002103	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
700508002104	molybdopterin cofactor binding site; other site
700508002105	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
700508002106	molybdopterin cofactor binding site; other site
700508002107	Predicted transcriptional regulators [Transcription]; Region: COG1733
700508002108	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700508002109	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508002110	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700508002111	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
700508002112	putative DNA binding site [nucleotide binding]; other site
700508002113	putative Zn2+ binding site [ion binding]; other site
700508002114	AsnC family; Region: AsnC_trans_reg; pfam01037
700508002115	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
700508002116	putative catalytic site [active]
700508002117	putative metal binding site [ion binding]; other site
700508002118	putative phosphate binding site [ion binding]; other site
700508002119	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
700508002120	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002121	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
700508002122	homodimer interface [polypeptide binding]; other site
700508002123	homotetramer interface [polypeptide binding]; other site
700508002124	active site pocket [active]
700508002125	cleavage site
700508002126	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
700508002127	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
700508002128	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
700508002129	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
700508002130	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
700508002131	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
700508002132	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
700508002133	nucleophilic elbow; other site
700508002134	catalytic triad; other site
700508002135	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
700508002136	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
700508002137	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
700508002138	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
700508002139	putative di-iron ligands [ion binding]; other site
700508002140	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
700508002141	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
700508002142	FAD binding pocket [chemical binding]; other site
700508002143	FAD binding motif [chemical binding]; other site
700508002144	phosphate binding motif [ion binding]; other site
700508002145	beta-alpha-beta structure motif; other site
700508002146	NAD(p) ribose binding residues [chemical binding]; other site
700508002147	NAD binding pocket [chemical binding]; other site
700508002148	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
700508002149	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508002150	catalytic loop [active]
700508002151	iron binding site [ion binding]; other site
700508002152	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
700508002153	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508002154	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
700508002155	NADP binding site [chemical binding]; other site
700508002156	dimer interface [polypeptide binding]; other site
700508002157	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
700508002158	peptide binding site [polypeptide binding]; other site
700508002159	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
700508002160	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
700508002161	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
700508002162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508002163	dimer interface [polypeptide binding]; other site
700508002164	conserved gate region; other site
700508002165	putative PBP binding loops; other site
700508002166	ABC-ATPase subunit interface; other site
700508002167	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700508002168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508002169	dimer interface [polypeptide binding]; other site
700508002170	conserved gate region; other site
700508002171	putative PBP binding loops; other site
700508002172	ABC-ATPase subunit interface; other site
700508002173	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
700508002174	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508002175	Walker A/P-loop; other site
700508002176	ATP binding site [chemical binding]; other site
700508002177	Q-loop/lid; other site
700508002178	ABC transporter signature motif; other site
700508002179	Walker B; other site
700508002180	D-loop; other site
700508002181	H-loop/switch region; other site
700508002182	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
700508002183	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
700508002184	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508002185	Walker A/P-loop; other site
700508002186	ATP binding site [chemical binding]; other site
700508002187	Q-loop/lid; other site
700508002188	ABC transporter signature motif; other site
700508002189	Walker B; other site
700508002190	D-loop; other site
700508002191	H-loop/switch region; other site
700508002192	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
700508002193	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
700508002194	hypothetical protein; Provisional; Region: PRK07236
700508002195	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508002196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002198	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700508002199	FAD binding domain; Region: FAD_binding_4; pfam01565
700508002200	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508002201	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508002202	non-specific DNA binding site [nucleotide binding]; other site
700508002203	salt bridge; other site
700508002204	sequence-specific DNA binding site [nucleotide binding]; other site
700508002205	HipA N-terminal domain; Region: Couple_hipA; pfam13657
700508002206	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
700508002207	HipA-like N-terminal domain; Region: HipA_N; pfam07805
700508002208	HipA-like C-terminal domain; Region: HipA_C; pfam07804
700508002209	Virulence protein [General function prediction only]; Region: COG3943
700508002210	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
700508002211	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
700508002212	ADP-ribose binding site [chemical binding]; other site
700508002213	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
700508002214	Helix-turn-helix domain; Region: HTH_17; cl17695
700508002215	Protein of unknown function (DUF2742); Region: DUF2742; pfam10888
700508002216	Domain of unknown function (DUF955); Region: DUF955; cl01076
700508002217	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700508002218	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
700508002219	active site
700508002220	DNA binding site [nucleotide binding]
700508002221	Int/Topo IB signature motif; other site
700508002222	Cupin domain; Region: Cupin_2; pfam07883
700508002223	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
700508002224	trimer interface [polypeptide binding]; other site
700508002225	active site
700508002226	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
700508002227	TAP-like protein; Region: Abhydrolase_4; pfam08386
700508002228	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508002229	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002230	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002231	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508002232	Cytochrome P450; Region: p450; cl12078
700508002233	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
700508002234	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
700508002235	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508002236	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
700508002237	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
700508002238	substrate binding site; other site
700508002239	tetramer interface; other site
700508002240	YibE/F-like protein; Region: YibE_F; pfam07907
700508002241	aminotransferase AlaT; Validated; Region: PRK09265
700508002242	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508002243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508002244	homodimer interface [polypeptide binding]; other site
700508002245	catalytic residue [active]
700508002246	4Fe-4S binding domain; Region: Fer4; cl02805
700508002247	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
700508002248	4Fe-4S binding domain; Region: Fer4; pfam00037
700508002249	Cysteine-rich domain; Region: CCG; pfam02754
700508002250	Cysteine-rich domain; Region: CCG; pfam02754
700508002251	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508002252	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508002253	DNA binding residues [nucleotide binding]
700508002254	dimerization interface [polypeptide binding]; other site
700508002255	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700508002256	nucleotide binding site [chemical binding]; other site
700508002257	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
700508002258	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
700508002259	G1 box; other site
700508002260	GTP/Mg2+ binding site [chemical binding]; other site
700508002261	G2 box; other site
700508002262	Switch I region; other site
700508002263	G3 box; other site
700508002264	Switch II region; other site
700508002265	G4 box; other site
700508002266	G5 box; other site
700508002267	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
700508002268	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508002269	TIGR03085 family protein; Region: TIGR03085
700508002270	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
700508002271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
700508002272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
700508002273	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
700508002274	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508002275	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
700508002276	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
700508002277	nucleotide binding site [chemical binding]; other site
700508002278	NEF interaction site [polypeptide binding]; other site
700508002279	SBD interface [polypeptide binding]; other site
700508002280	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
700508002281	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
700508002282	dimer interface [polypeptide binding]; other site
700508002283	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
700508002284	chaperone protein DnaJ; Provisional; Region: PRK14279
700508002285	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700508002286	HSP70 interaction site [polypeptide binding]; other site
700508002287	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
700508002288	Zn binding sites [ion binding]; other site
700508002289	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
700508002290	dimer interface [polypeptide binding]; other site
700508002291	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
700508002292	DNA binding residues [nucleotide binding]
700508002293	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508002294	putative dimer interface [polypeptide binding]; other site
700508002295	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
700508002296	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
700508002297	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
700508002298	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
700508002299	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
700508002300	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
700508002301	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
700508002302	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
700508002303	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508002304	MarR family; Region: MarR_2; pfam12802
700508002305	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700508002306	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
700508002307	putative ligand binding site [chemical binding]; other site
700508002308	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
700508002309	active site
700508002310	catalytic residues [active]
700508002311	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
700508002312	heme-binding site [chemical binding]; other site
700508002313	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
700508002314	FMN reductase; Validated; Region: fre; PRK08051
700508002315	FAD binding pocket [chemical binding]; other site
700508002316	FAD binding motif [chemical binding]; other site
700508002317	phosphate binding motif [ion binding]; other site
700508002318	beta-alpha-beta structure motif; other site
700508002319	NAD binding pocket [chemical binding]; other site
700508002320	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
700508002321	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
700508002322	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
700508002323	putative active site [active]
700508002324	putative metal binding residues [ion binding]; other site
700508002325	signature motif; other site
700508002326	putative dimer interface [polypeptide binding]; other site
700508002327	putative phosphate binding site [ion binding]; other site
700508002328	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
700508002329	Clp amino terminal domain; Region: Clp_N; pfam02861
700508002330	Clp amino terminal domain; Region: Clp_N; pfam02861
700508002331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508002332	Walker A motif; other site
700508002333	ATP binding site [chemical binding]; other site
700508002334	Walker B motif; other site
700508002335	arginine finger; other site
700508002336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508002337	Walker A motif; other site
700508002338	ATP binding site [chemical binding]; other site
700508002339	Walker B motif; other site
700508002340	arginine finger; other site
700508002341	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
700508002342	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
700508002343	classical (c) SDRs; Region: SDR_c; cd05233
700508002344	NAD(P) binding site [chemical binding]; other site
700508002345	active site
700508002346	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
700508002347	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700508002348	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
700508002349	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
700508002350	Thioredoxin; Region: Thioredoxin_4; pfam13462
700508002351	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
700508002352	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
700508002353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508002354	putative substrate translocation pore; other site
700508002355	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002356	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002357	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
700508002358	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
700508002359	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
700508002360	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
700508002361	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
700508002362	active site
700508002363	intersubunit interface [polypeptide binding]; other site
700508002364	zinc binding site [ion binding]; other site
700508002365	Na+ binding site [ion binding]; other site
700508002366	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
700508002367	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
700508002368	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
700508002369	Peptidase family M50; Region: Peptidase_M50; pfam02163
700508002370	active site
700508002371	putative substrate binding region [chemical binding]; other site
700508002372	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
700508002373	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
700508002374	GDP-binding site [chemical binding]; other site
700508002375	ACT binding site; other site
700508002376	IMP binding site; other site
700508002377	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508002378	CoenzymeA binding site [chemical binding]; other site
700508002379	subunit interaction site [polypeptide binding]; other site
700508002380	PHB binding site; other site
700508002381	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508002382	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508002383	active site
700508002384	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
700508002385	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
700508002386	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508002387	Cytochrome P450; Region: p450; cl12078
700508002388	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
700508002389	MMPL family; Region: MMPL; pfam03176
700508002390	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700508002391	MarR family; Region: MarR_2; pfam12802
700508002392	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
700508002393	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
700508002394	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508002395	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
700508002396	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
700508002397	active site residue [active]
700508002398	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
700508002399	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508002400	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508002401	catalytic residue [active]
700508002402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508002403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508002404	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
700508002405	dimerization interface [polypeptide binding]; other site
700508002406	substrate binding pocket [chemical binding]; other site
700508002407	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
700508002408	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
700508002409	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
700508002410	homodimer interface [polypeptide binding]; other site
700508002411	substrate-cofactor binding pocket; other site
700508002412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508002413	catalytic residue [active]
700508002414	short chain dehydrogenase; Provisional; Region: PRK07825
700508002415	classical (c) SDRs; Region: SDR_c; cd05233
700508002416	NAD(P) binding site [chemical binding]; other site
700508002417	active site
700508002418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508002419	Coenzyme A binding pocket [chemical binding]; other site
700508002420	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
700508002421	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
700508002422	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700508002423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508002424	S-adenosylmethionine binding site [chemical binding]; other site
700508002425	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508002426	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
700508002427	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
700508002428	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508002429	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700508002430	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508002431	DNA-binding site [nucleotide binding]; DNA binding site
700508002432	UTRA domain; Region: UTRA; pfam07702
700508002433	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508002434	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508002435	NAD(P) binding site [chemical binding]; other site
700508002436	active site
700508002437	Phosphotransferase enzyme family; Region: APH; pfam01636
700508002438	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508002439	amino acid transporter; Region: 2A0306; TIGR00909
700508002440	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
700508002441	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508002442	inhibitor-cofactor binding pocket; inhibition site
700508002443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508002444	catalytic residue [active]
700508002445	phosphate acetyltransferase; Reviewed; Region: PRK05632
700508002446	DRTGG domain; Region: DRTGG; pfam07085
700508002447	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
700508002448	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
700508002449	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508002450	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508002451	active site
700508002452	ATP binding site [chemical binding]; other site
700508002453	substrate binding site [chemical binding]; other site
700508002454	activation loop (A-loop); other site
700508002455	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508002456	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508002457	substrate binding pocket [chemical binding]; other site
700508002458	membrane-bound complex binding site; other site
700508002459	hinge residues; other site
700508002460	NUDIX domain; Region: NUDIX; pfam00293
700508002461	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
700508002462	thiamine phosphate binding site [chemical binding]; other site
700508002463	active site
700508002464	pyrophosphate binding site [ion binding]; other site
700508002465	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
700508002466	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
700508002467	thiS-thiF/thiG interaction site; other site
700508002468	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
700508002469	ThiS interaction site; other site
700508002470	putative active site [active]
700508002471	tetramer interface [polypeptide binding]; other site
700508002472	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700508002473	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
700508002474	Walker A/P-loop; other site
700508002475	ATP binding site [chemical binding]; other site
700508002476	Q-loop/lid; other site
700508002477	ABC transporter signature motif; other site
700508002478	Walker B; other site
700508002479	D-loop; other site
700508002480	H-loop/switch region; other site
700508002481	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
700508002482	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700508002483	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
700508002484	PA/protease or protease-like domain interface [polypeptide binding]; other site
700508002485	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
700508002486	Peptidase family M28; Region: Peptidase_M28; pfam04389
700508002487	active site
700508002488	metal binding site [ion binding]; metal-binding site
700508002489	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700508002490	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
700508002491	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
700508002492	Peptidase family M28; Region: Peptidase_M28; pfam04389
700508002493	metal binding site [ion binding]; metal-binding site
700508002494	MMPL family; Region: MMPL; pfam03176
700508002495	MMPL family; Region: MMPL; pfam03176
700508002496	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
700508002497	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
700508002498	malonyl-CoA binding site [chemical binding]; other site
700508002499	dimer interface [polypeptide binding]; other site
700508002500	active site
700508002501	product binding site; other site
700508002502	Phospholipid methyltransferase; Region: PEMT; cl17370
700508002503	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
700508002504	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508002505	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
700508002506	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
700508002507	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
700508002508	NAD(P) binding site [chemical binding]; other site
700508002509	catalytic residues [active]
700508002510	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
700508002511	NAD(P) binding site [chemical binding]; other site
700508002512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508002513	active site
700508002514	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508002515	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
700508002516	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
700508002517	acyl-activating enzyme (AAE) consensus motif; other site
700508002518	acyl-activating enzyme (AAE) consensus motif; other site
700508002519	putative AMP binding site [chemical binding]; other site
700508002520	putative active site [active]
700508002521	putative CoA binding site [chemical binding]; other site
700508002522	amino acid transporter; Region: 2A0306; TIGR00909
700508002523	Predicted membrane protein [Function unknown]; Region: COG4270
700508002524	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508002525	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508002526	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700508002527	Septum formation; Region: Septum_form; pfam13845
700508002528	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
700508002529	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
700508002530	dimer interface [polypeptide binding]; other site
700508002531	substrate binding site [chemical binding]; other site
700508002532	ATP binding site [chemical binding]; other site
700508002533	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
700508002534	ThiC-associated domain; Region: ThiC-associated; pfam13667
700508002535	ThiC family; Region: ThiC; pfam01964
700508002536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508002537	putative substrate translocation pore; other site
700508002538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508002539	putative substrate translocation pore; other site
700508002540	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002541	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002542	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
700508002543	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700508002544	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
700508002545	FMN-binding pocket [chemical binding]; other site
700508002546	flavin binding motif; other site
700508002547	phosphate binding motif [ion binding]; other site
700508002548	beta-alpha-beta structure motif; other site
700508002549	NAD binding pocket [chemical binding]; other site
700508002550	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508002551	catalytic loop [active]
700508002552	iron binding site [ion binding]; other site
700508002553	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
700508002554	PPE family; Region: PPE; pfam00823
700508002555	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
700508002556	FAD binding pocket [chemical binding]; other site
700508002557	conserved FAD binding motif [chemical binding]; other site
700508002558	phosphate binding motif [ion binding]; other site
700508002559	beta-alpha-beta structure motif; other site
700508002560	NAD binding pocket [chemical binding]; other site
700508002561	Phosphotransferase enzyme family; Region: APH; pfam01636
700508002562	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
700508002563	putative active site [active]
700508002564	putative substrate binding site [chemical binding]; other site
700508002565	ATP binding site [chemical binding]; other site
700508002566	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002567	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700508002568	classical (c) SDRs; Region: SDR_c; cd05233
700508002569	NAD(P) binding site [chemical binding]; other site
700508002570	active site
700508002571	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508002572	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508002573	active site
700508002574	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
700508002575	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700508002576	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700508002577	NAD(P) binding site [chemical binding]; other site
700508002578	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
700508002579	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700508002580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508002581	S-adenosylmethionine binding site [chemical binding]; other site
700508002582	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
700508002583	putative catalytic site [active]
700508002584	putative phosphate binding site [ion binding]; other site
700508002585	active site
700508002586	metal binding site A [ion binding]; metal-binding site
700508002587	DNA binding site [nucleotide binding]
700508002588	putative AP binding site [nucleotide binding]; other site
700508002589	putative metal binding site B [ion binding]; other site
700508002590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
700508002591	P-loop containing region of AAA domain; Region: AAA_29; cl17516
700508002592	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
700508002593	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
700508002594	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
700508002595	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508002596	Coenzyme A binding pocket [chemical binding]; other site
700508002597	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
700508002598	active site
700508002599	catalytic residues [active]
700508002600	metal binding site [ion binding]; metal-binding site
700508002601	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
700508002602	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
700508002603	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
700508002604	E-class dimer interface [polypeptide binding]; other site
700508002605	P-class dimer interface [polypeptide binding]; other site
700508002606	active site
700508002607	Cu2+ binding site [ion binding]; other site
700508002608	Zn2+ binding site [ion binding]; other site
700508002609	carboxylate-amine ligase; Provisional; Region: PRK13517
700508002610	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
700508002611	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
700508002612	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
700508002613	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
700508002614	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
700508002615	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
700508002616	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700508002617	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
700508002618	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
700508002619	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
700508002620	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700508002621	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
700508002622	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
700508002623	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
700508002624	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
700508002625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508002626	Walker A motif; other site
700508002627	ATP binding site [chemical binding]; other site
700508002628	Walker B motif; other site
700508002629	arginine finger; other site
700508002630	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508002631	Walker A motif; other site
700508002632	ATP binding site [chemical binding]; other site
700508002633	Walker B motif; other site
700508002634	arginine finger; other site
700508002635	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
700508002636	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
700508002637	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
700508002638	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
700508002639	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
700508002640	dimer interface [polypeptide binding]; other site
700508002641	putative functional site; other site
700508002642	putative MPT binding site; other site
700508002643	short chain dehydrogenase; Provisional; Region: PRK06197
700508002644	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
700508002645	putative NAD(P) binding site [chemical binding]; other site
700508002646	active site
700508002647	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700508002648	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508002649	substrate binding site [chemical binding]; other site
700508002650	oxyanion hole (OAH) forming residues; other site
700508002651	trimer interface [polypeptide binding]; other site
700508002652	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508002653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508002654	active site
700508002655	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
700508002656	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508002657	acyl-activating enzyme (AAE) consensus motif; other site
700508002658	AMP binding site [chemical binding]; other site
700508002659	active site
700508002660	CoA binding site [chemical binding]; other site
700508002661	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700508002662	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508002663	substrate binding site [chemical binding]; other site
700508002664	oxyanion hole (OAH) forming residues; other site
700508002665	trimer interface [polypeptide binding]; other site
700508002666	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508002667	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700508002668	classical (c) SDRs; Region: SDR_c; cd05233
700508002669	NAD(P) binding site [chemical binding]; other site
700508002670	active site
700508002671	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002672	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002673	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508002674	Cytochrome P450; Region: p450; cl12078
700508002675	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
700508002676	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508002677	active site
700508002678	motif I; other site
700508002679	motif II; other site
700508002680	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508002681	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
700508002682	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508002683	ATP binding site [chemical binding]; other site
700508002684	putative Mg++ binding site [ion binding]; other site
700508002685	Cupin domain; Region: Cupin_2; pfam07883
700508002686	short chain dehydrogenase; Provisional; Region: PRK06197
700508002687	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
700508002688	putative NAD(P) binding site [chemical binding]; other site
700508002689	active site
700508002690	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002691	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002692	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
700508002693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508002694	ABC-ATPase subunit interface; other site
700508002695	putative PBP binding loops; other site
700508002696	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
700508002697	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508002698	Walker A/P-loop; other site
700508002699	ATP binding site [chemical binding]; other site
700508002700	Q-loop/lid; other site
700508002701	ABC transporter signature motif; other site
700508002702	Walker B; other site
700508002703	D-loop; other site
700508002704	H-loop/switch region; other site
700508002705	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
700508002706	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508002707	substrate binding pocket [chemical binding]; other site
700508002708	membrane-bound complex binding site; other site
700508002709	hinge residues; other site
700508002710	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
700508002711	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
700508002712	ring oligomerisation interface [polypeptide binding]; other site
700508002713	ATP/Mg binding site [chemical binding]; other site
700508002714	stacking interactions; other site
700508002715	hinge regions; other site
700508002716	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
700508002717	putative active site [active]
700508002718	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
700508002719	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508002720	active site
700508002721	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508002722	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
700508002723	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508002724	Protein of unknown function (DUF664); Region: DUF664; pfam04978
700508002725	DinB superfamily; Region: DinB_2; pfam12867
700508002726	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
700508002727	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
700508002728	NAD(P) binding site [chemical binding]; other site
700508002729	catalytic residues [active]
700508002730	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
700508002731	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508002732	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
700508002733	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
700508002734	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508002735	Protein of unknown function (DUF779); Region: DUF779; pfam05610
700508002736	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
700508002737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
700508002738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508002739	S-adenosylmethionine binding site [chemical binding]; other site
700508002740	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
700508002741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
700508002742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508002743	S-adenosylmethionine binding site [chemical binding]; other site
700508002744	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
700508002745	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
700508002746	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508002747	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
700508002748	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508002749	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508002750	metal binding site [ion binding]; metal-binding site
700508002751	active site
700508002752	I-site; other site
700508002753	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700508002754	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700508002755	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508002756	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508002757	non-specific DNA binding site [nucleotide binding]; other site
700508002758	salt bridge; other site
700508002759	sequence-specific DNA binding site [nucleotide binding]; other site
700508002760	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
700508002761	Domain of unknown function (DUF955); Region: DUF955; pfam06114
700508002762	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
700508002763	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
700508002764	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508002765	active site 2 [active]
700508002766	active site 1 [active]
700508002767	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508002768	isocitrate lyase; Provisional; Region: PRK15063
700508002769	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
700508002770	tetramer interface [polypeptide binding]; other site
700508002771	active site
700508002772	Mg2+/Mn2+ binding site [ion binding]; other site
700508002773	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
700508002774	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
700508002775	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
700508002776	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
700508002777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508002778	S-adenosylmethionine binding site [chemical binding]; other site
700508002779	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
700508002780	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002781	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002782	Predicted membrane protein [Function unknown]; Region: COG2733
700508002783	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508002784	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508002785	non-specific DNA binding site [nucleotide binding]; other site
700508002786	salt bridge; other site
700508002787	sequence-specific DNA binding site [nucleotide binding]; other site
700508002788	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
700508002789	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
700508002790	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
700508002791	Predicted amidohydrolase [General function prediction only]; Region: COG0388
700508002792	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
700508002793	putative active site [active]
700508002794	catalytic triad [active]
700508002795	putative dimer interface [polypeptide binding]; other site
700508002796	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
700508002797	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
700508002798	FAD binding domain; Region: FAD_binding_4; pfam01565
700508002799	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
700508002800	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
700508002801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
700508002802	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
700508002803	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700508002804	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
700508002805	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508002806	NAD(P) binding site [chemical binding]; other site
700508002807	active site
700508002808	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700508002809	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700508002810	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
700508002811	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
700508002812	putative ADP-binding pocket [chemical binding]; other site
700508002813	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
700508002814	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508002815	catalytic core [active]
700508002816	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
700508002817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508002818	dimer interface [polypeptide binding]; other site
700508002819	phosphorylation site [posttranslational modification]
700508002820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508002821	ATP binding site [chemical binding]; other site
700508002822	Mg2+ binding site [ion binding]; other site
700508002823	G-X-G motif; other site
700508002824	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508002825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508002826	active site
700508002827	phosphorylation site [posttranslational modification]
700508002828	intermolecular recognition site; other site
700508002829	dimerization interface [polypeptide binding]; other site
700508002830	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508002831	DNA binding site [nucleotide binding]
700508002832	exopolyphosphatase; Region: exo_poly_only; TIGR03706
700508002833	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
700508002834	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
700508002835	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
700508002836	DNA interaction; other site
700508002837	Metal-binding active site; metal-binding site
700508002838	AP (apurinic/apyrimidinic) site pocket; other site
700508002839	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
700508002840	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508002841	active site 2 [active]
700508002842	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
700508002843	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
700508002844	DNA binding domain, excisionase family; Region: excise; TIGR01764
700508002845	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700508002846	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
700508002847	putative NAD(P) binding site [chemical binding]; other site
700508002848	active site
700508002849	putative substrate binding site [chemical binding]; other site
700508002850	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700508002851	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
700508002852	putative acyl-acceptor binding pocket; other site
700508002853	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
700508002854	active site
700508002855	catalytic site [active]
700508002856	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
700508002857	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700508002858	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
700508002859	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
700508002860	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
700508002861	NAD(P) binding pocket [chemical binding]; other site
700508002862	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
700508002863	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
700508002864	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
700508002865	domain interfaces; other site
700508002866	active site
700508002867	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
700508002868	homodimer interface [polypeptide binding]; other site
700508002869	active site
700508002870	SAM binding site [chemical binding]; other site
700508002871	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
700508002872	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
700508002873	active site
700508002874	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
700508002875	dimer interface [polypeptide binding]; other site
700508002876	active site
700508002877	Schiff base residues; other site
700508002878	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508002879	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508002880	active site
700508002881	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
700508002882	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002883	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002884	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
700508002885	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508002886	inhibitor-cofactor binding pocket; inhibition site
700508002887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508002888	catalytic residue [active]
700508002889	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508002890	catalytic core [active]
700508002891	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700508002892	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700508002893	catalytic residues [active]
700508002894	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
700508002895	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
700508002896	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
700508002897	ResB-like family; Region: ResB; pfam05140
700508002898	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
700508002899	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
700508002900	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
700508002901	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
700508002902	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700508002903	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508002904	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508002905	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
700508002906	DNA binding residues [nucleotide binding]
700508002907	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
700508002908	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
700508002909	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
700508002910	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700508002911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508002912	NAD(P) binding site [chemical binding]; other site
700508002913	active site
700508002914	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
700508002915	Ligand binding site; other site
700508002916	Putative Catalytic site; other site
700508002917	DXD motif; other site
700508002918	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
700508002919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508002920	S-adenosylmethionine binding site [chemical binding]; other site
700508002921	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
700508002922	Moco binding site; other site
700508002923	metal coordination site [ion binding]; other site
700508002924	Nitronate monooxygenase; Region: NMO; pfam03060
700508002925	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700508002926	FMN binding site [chemical binding]; other site
700508002927	substrate binding site [chemical binding]; other site
700508002928	putative catalytic residue [active]
700508002929	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700508002930	cyclase homology domain; Region: CHD; cd07302
700508002931	nucleotidyl binding site; other site
700508002932	metal binding site [ion binding]; metal-binding site
700508002933	dimer interface [polypeptide binding]; other site
700508002934	Cutinase; Region: Cutinase; pfam01083
700508002935	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
700508002936	PhoU domain; Region: PhoU; pfam01895
700508002937	PhoU domain; Region: PhoU; pfam01895
700508002938	AzlC protein; Region: AzlC; cl00570
700508002939	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
700508002940	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508002941	Coenzyme A binding pocket [chemical binding]; other site
700508002942	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
700508002943	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
700508002944	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508002945	active site
700508002946	CoA binding site [chemical binding]; other site
700508002947	AMP binding site [chemical binding]; other site
700508002948	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
700508002949	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
700508002950	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
700508002951	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508002952	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508002953	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508002954	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
700508002955	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508002956	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508002957	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
700508002958	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508002959	active site
700508002960	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
700508002961	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508002962	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
700508002963	classical (c) SDRs; Region: SDR_c; cd05233
700508002964	NAD(P) binding site [chemical binding]; other site
700508002965	active site
700508002966	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700508002967	classical (c) SDRs; Region: SDR_c; cd05233
700508002968	NAD(P) binding site [chemical binding]; other site
700508002969	active site
700508002970	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
700508002971	agmatinase; Region: agmatinase; TIGR01230
700508002972	oligomer interface [polypeptide binding]; other site
700508002973	putative active site [active]
700508002974	Mn binding site [ion binding]; other site
700508002975	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
700508002976	tetramer interface [polypeptide binding]; other site
700508002977	active site
700508002978	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
700508002979	short chain dehydrogenase; Provisional; Region: PRK05866
700508002980	classical (c) SDRs; Region: SDR_c; cd05233
700508002981	NAD(P) binding site [chemical binding]; other site
700508002982	active site
700508002983	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
700508002984	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
700508002985	putative active site [active]
700508002986	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508002987	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
700508002988	substrate binding site [chemical binding]; other site
700508002989	oxyanion hole (OAH) forming residues; other site
700508002990	trimer interface [polypeptide binding]; other site
700508002991	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
700508002992	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508002993	motif II; other site
700508002994	hypothetical protein; Provisional; Region: PRK01346
700508002995	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
700508002996	SOUL heme-binding protein; Region: SOUL; pfam04832
700508002997	acyl-CoA synthetase; Validated; Region: PRK06188
700508002998	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
700508002999	putative active site [active]
700508003000	putative CoA binding site [chemical binding]; other site
700508003001	putative AMP binding site [chemical binding]; other site
700508003002	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
700508003003	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
700508003004	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
700508003005	active site
700508003006	O-succinylbenzoate synthase; Provisional; Region: PRK02901
700508003007	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
700508003008	active site
700508003009	HicB family; Region: HicB; pfam05534
700508003010	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
700508003011	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
700508003012	conserved cys residue [active]
700508003013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508003014	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508003015	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
700508003016	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
700508003017	conserved cys residue [active]
700508003018	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508003019	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
700508003020	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
700508003021	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
700508003022	dimer interface [polypeptide binding]; other site
700508003023	tetramer interface [polypeptide binding]; other site
700508003024	PYR/PP interface [polypeptide binding]; other site
700508003025	TPP binding site [chemical binding]; other site
700508003026	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
700508003027	TPP-binding site; other site
700508003028	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
700508003029	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
700508003030	catalytic residues [active]
700508003031	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508003032	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
700508003033	Tubulin like; Region: Tubulin_2; pfam13809
700508003034	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700508003035	PknH-like extracellular domain; Region: PknH_C; pfam14032
700508003036	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700508003037	PknH-like extracellular domain; Region: PknH_C; pfam14032
700508003038	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700508003039	PknH-like extracellular domain; Region: PknH_C; pfam14032
700508003040	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
700508003041	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700508003042	PknH-like extracellular domain; Region: PknH_C; pfam14032
700508003043	short chain dehydrogenase; Provisional; Region: PRK08263
700508003044	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700508003045	NADP binding site [chemical binding]; other site
700508003046	active site
700508003047	steroid binding site; other site
700508003048	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
700508003049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508003050	S-adenosylmethionine binding site [chemical binding]; other site
700508003051	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
700508003052	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
700508003053	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
700508003054	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700508003055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508003056	NAD(P) binding site [chemical binding]; other site
700508003057	active site
700508003058	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700508003059	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
700508003060	putative acyl-acceptor binding pocket; other site
700508003061	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508003062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508003063	non-specific DNA binding site [nucleotide binding]; other site
700508003064	salt bridge; other site
700508003065	sequence-specific DNA binding site [nucleotide binding]; other site
700508003066	Cupin domain; Region: Cupin_2; pfam07883
700508003067	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
700508003068	intersubunit interface [polypeptide binding]; other site
700508003069	active site
700508003070	Zn2+ binding site [ion binding]; other site
700508003071	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700508003072	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
700508003073	inhibitor site; inhibition site
700508003074	active site
700508003075	dimer interface [polypeptide binding]; other site
700508003076	catalytic residue [active]
700508003077	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
700508003078	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508003079	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508003080	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508003081	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508003082	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
700508003083	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
700508003084	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
700508003085	substrate binding pocket [chemical binding]; other site
700508003086	chain length determination region; other site
700508003087	substrate-Mg2+ binding site; other site
700508003088	catalytic residues [active]
700508003089	aspartate-rich region 1; other site
700508003090	active site lid residues [active]
700508003091	aspartate-rich region 2; other site
700508003092	heat shock protein HtpX; Provisional; Region: PRK03072
700508003093	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
700508003094	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
700508003095	putative active site [active]
700508003096	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
700508003097	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
700508003098	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
700508003099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
700508003100	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
700508003101	PE-PPE domain; Region: PE-PPE; pfam08237
700508003102	Cutinase; Region: Cutinase; pfam01083
700508003103	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
700508003104	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700508003105	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508003106	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508003107	metal binding site [ion binding]; metal-binding site
700508003108	active site
700508003109	I-site; other site
700508003110	TspO/MBR family; Region: TspO_MBR; pfam03073
700508003111	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
700508003112	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
700508003113	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508003114	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508003115	active site
700508003116	ATP binding site [chemical binding]; other site
700508003117	substrate binding site [chemical binding]; other site
700508003118	activation loop (A-loop); other site
700508003119	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508003120	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508003121	substrate binding pocket [chemical binding]; other site
700508003122	membrane-bound complex binding site; other site
700508003123	hinge residues; other site
700508003124	NYN domain; Region: NYN; pfam01936
700508003125	Uncharacterized conserved protein [Function unknown]; Region: COG1432
700508003126	putative metal binding site [ion binding]; other site
700508003127	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
700508003128	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700508003129	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
700508003130	putative di-iron ligands [ion binding]; other site
700508003131	CsbD-like; Region: CsbD; cl17424
700508003132	GAF domain; Region: GAF_3; pfam13492
700508003133	GAF domain; Region: GAF_2; pfam13185
700508003134	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
700508003135	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
700508003136	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508003137	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
700508003138	active site
700508003139	AAA domain; Region: AAA_30; pfam13604
700508003140	Family description; Region: UvrD_C_2; pfam13538
700508003141	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
700508003142	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
700508003143	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
700508003144	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
700508003145	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
700508003146	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
700508003147	EamA-like transporter family; Region: EamA; pfam00892
700508003148	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508003149	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
700508003150	DNA-binding site [nucleotide binding]; DNA binding site
700508003151	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508003152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508003153	homodimer interface [polypeptide binding]; other site
700508003154	catalytic residue [active]
700508003155	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700508003156	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508003157	substrate binding site [chemical binding]; other site
700508003158	oxyanion hole (OAH) forming residues; other site
700508003159	trimer interface [polypeptide binding]; other site
700508003160	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
700508003161	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
700508003162	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
700508003163	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700508003164	Rrf2 family protein; Region: rrf2_super; TIGR00738
700508003165	Transcriptional regulator; Region: Rrf2; cl17282
700508003166	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
700508003167	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
700508003168	heme-binding site [chemical binding]; other site
700508003169	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
700508003170	FAD binding pocket [chemical binding]; other site
700508003171	FAD binding motif [chemical binding]; other site
700508003172	phosphate binding motif [ion binding]; other site
700508003173	beta-alpha-beta structure motif; other site
700508003174	NAD binding pocket [chemical binding]; other site
700508003175	Heme binding  pocket [chemical binding]; other site
700508003176	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
700508003177	putative active site [active]
700508003178	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
700508003179	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
700508003180	active site
700508003181	catalytic site [active]
700508003182	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
700508003183	active site
700508003184	catalytic site [active]
700508003185	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
700508003186	active site
700508003187	catalytic site [active]
700508003188	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
700508003189	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
700508003190	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
700508003191	putative homodimer interface [polypeptide binding]; other site
700508003192	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
700508003193	heterodimer interface [polypeptide binding]; other site
700508003194	homodimer interface [polypeptide binding]; other site
700508003195	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
700508003196	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
700508003197	23S rRNA interface [nucleotide binding]; other site
700508003198	L7/L12 interface [polypeptide binding]; other site
700508003199	putative thiostrepton binding site; other site
700508003200	L25 interface [polypeptide binding]; other site
700508003201	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
700508003202	mRNA/rRNA interface [nucleotide binding]; other site
700508003203	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
700508003204	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
700508003205	substrate binding site; other site
700508003206	tetramer interface; other site
700508003207	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
700508003208	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
700508003209	NAD binding site [chemical binding]; other site
700508003210	substrate binding site [chemical binding]; other site
700508003211	homodimer interface [polypeptide binding]; other site
700508003212	active site
700508003213	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
700508003214	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
700508003215	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
700508003216	NADP binding site [chemical binding]; other site
700508003217	active site
700508003218	putative substrate binding site [chemical binding]; other site
700508003219	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
700508003220	putative catalytic site [active]
700508003221	putative metal binding site [ion binding]; other site
700508003222	putative phosphate binding site [ion binding]; other site
700508003223	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
700508003224	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700508003225	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700508003226	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
700508003227	Probable Catalytic site; other site
700508003228	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
700508003229	Chain length determinant protein; Region: Wzz; pfam02706
700508003230	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
700508003231	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700508003232	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
700508003233	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
700508003234	putative catalytic site [active]
700508003235	putative metal binding site [ion binding]; other site
700508003236	putative phosphate binding site [ion binding]; other site
700508003237	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
700508003238	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508003239	S-adenosylmethionine binding site [chemical binding]; other site
700508003240	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
700508003241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
700508003242	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508003243	S-adenosylmethionine binding site [chemical binding]; other site
700508003244	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508003245	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
700508003246	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
700508003247	ABC1 family; Region: ABC1; cl17513
700508003248	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
700508003249	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508003250	Protein of unknown function (DUF664); Region: DUF664; pfam04978
700508003251	DinB superfamily; Region: DinB_2; pfam12867
700508003252	DinB superfamily; Region: DinB_2; pfam12867
700508003253	Predicted transcriptional regulator [Transcription]; Region: COG2378
700508003254	HTH domain; Region: HTH_11; pfam08279
700508003255	WYL domain; Region: WYL; pfam13280
700508003256	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
700508003257	active site
700508003258	catalytic site [active]
700508003259	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
700508003260	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
700508003261	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
700508003262	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700508003263	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
700508003264	nucleotide binding site [chemical binding]; other site
700508003265	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
700508003266	23S rRNA interface [nucleotide binding]; other site
700508003267	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
700508003268	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
700508003269	core dimer interface [polypeptide binding]; other site
700508003270	peripheral dimer interface [polypeptide binding]; other site
700508003271	L10 interface [polypeptide binding]; other site
700508003272	L11 interface [polypeptide binding]; other site
700508003273	putative EF-Tu interaction site [polypeptide binding]; other site
700508003274	putative EF-G interaction site [polypeptide binding]; other site
700508003275	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
700508003276	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
700508003277	Walker A/P-loop; other site
700508003278	ATP binding site [chemical binding]; other site
700508003279	Q-loop/lid; other site
700508003280	ABC transporter signature motif; other site
700508003281	Walker B; other site
700508003282	D-loop; other site
700508003283	H-loop/switch region; other site
700508003284	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
700508003285	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
700508003286	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
700508003287	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
700508003288	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
700508003289	RPB10 interaction site [polypeptide binding]; other site
700508003290	RPB1 interaction site [polypeptide binding]; other site
700508003291	RPB11 interaction site [polypeptide binding]; other site
700508003292	RPB3 interaction site [polypeptide binding]; other site
700508003293	RPB12 interaction site [polypeptide binding]; other site
700508003294	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
700508003295	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
700508003296	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
700508003297	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
700508003298	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
700508003299	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
700508003300	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
700508003301	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
700508003302	DNA binding site [nucleotide binding]
700508003303	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
700508003304	endonuclease IV; Provisional; Region: PRK01060
700508003305	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
700508003306	AP (apurinic/apyrimidinic) site pocket; other site
700508003307	DNA interaction; other site
700508003308	Metal-binding active site; metal-binding site
700508003309	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
700508003310	active site
700508003311	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508003312	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
700508003313	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
700508003314	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
700508003315	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508003316	active site
700508003317	enoyl-CoA hydratase; Provisional; Region: PRK12478
700508003318	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508003319	substrate binding site [chemical binding]; other site
700508003320	oxyanion hole (OAH) forming residues; other site
700508003321	trimer interface [polypeptide binding]; other site
700508003322	PaaX-like protein; Region: PaaX; pfam07848
700508003323	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
700508003324	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700508003325	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508003326	substrate binding site [chemical binding]; other site
700508003327	oxyanion hole (OAH) forming residues; other site
700508003328	trimer interface [polypeptide binding]; other site
700508003329	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
700508003330	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
700508003331	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
700508003332	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508003333	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508003334	WHG domain; Region: WHG; pfam13305
700508003335	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
700508003336	S17 interaction site [polypeptide binding]; other site
700508003337	S8 interaction site; other site
700508003338	16S rRNA interaction site [nucleotide binding]; other site
700508003339	streptomycin interaction site [chemical binding]; other site
700508003340	23S rRNA interaction site [nucleotide binding]; other site
700508003341	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
700508003342	30S ribosomal protein S7; Validated; Region: PRK05302
700508003343	elongation factor G; Reviewed; Region: PRK00007
700508003344	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
700508003345	G1 box; other site
700508003346	putative GEF interaction site [polypeptide binding]; other site
700508003347	GTP/Mg2+ binding site [chemical binding]; other site
700508003348	Switch I region; other site
700508003349	G2 box; other site
700508003350	G3 box; other site
700508003351	Switch II region; other site
700508003352	G4 box; other site
700508003353	G5 box; other site
700508003354	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
700508003355	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
700508003356	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
700508003357	elongation factor Tu; Reviewed; Region: PRK00049
700508003358	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
700508003359	G1 box; other site
700508003360	GEF interaction site [polypeptide binding]; other site
700508003361	GTP/Mg2+ binding site [chemical binding]; other site
700508003362	Switch I region; other site
700508003363	G2 box; other site
700508003364	G3 box; other site
700508003365	Switch II region; other site
700508003366	G4 box; other site
700508003367	G5 box; other site
700508003368	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
700508003369	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
700508003370	Antibiotic Binding Site [chemical binding]; other site
700508003371	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508003372	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
700508003373	DNA binding residues [nucleotide binding]
700508003374	dimerization interface [polypeptide binding]; other site
700508003375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508003376	ATP binding site [chemical binding]; other site
700508003377	Mg2+ binding site [ion binding]; other site
700508003378	G-X-G motif; other site
700508003379	Short C-terminal domain; Region: SHOCT; pfam09851
700508003380	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
700508003381	classical (c) SDRs; Region: SDR_c; cd05233
700508003382	NAD(P) binding site [chemical binding]; other site
700508003383	active site
700508003384	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
700508003385	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508003386	inhibitor-cofactor binding pocket; inhibition site
700508003387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508003388	catalytic residue [active]
700508003389	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
700508003390	Amidinotransferase; Region: Amidinotransf; pfam02274
700508003391	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
700508003392	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
700508003393	putative DNA binding site [nucleotide binding]; other site
700508003394	putative Zn2+ binding site [ion binding]; other site
700508003395	AsnC family; Region: AsnC_trans_reg; pfam01037
700508003396	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
700508003397	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508003398	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
700508003399	putative dimer interface [polypeptide binding]; other site
700508003400	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508003401	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
700508003402	active site
700508003403	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
700508003404	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700508003405	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508003406	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508003407	DNA binding residues [nucleotide binding]
700508003408	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
700508003409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508003410	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
700508003411	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
700508003412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508003413	FeS/SAM binding site; other site
700508003414	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
700508003415	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
700508003416	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
700508003417	phosphate binding site [ion binding]; other site
700508003418	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
700508003419	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
700508003420	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
700508003421	active site
700508003422	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
700508003423	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700508003424	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
700508003425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508003426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508003427	putative substrate translocation pore; other site
700508003428	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508003429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508003430	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508003431	Cytochrome P450; Region: p450; cl12078
700508003432	Carboxylesterase family; Region: COesterase; pfam00135
700508003433	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508003434	substrate binding pocket [chemical binding]; other site
700508003435	catalytic triad [active]
700508003436	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508003437	active site 2 [active]
700508003438	active site 1 [active]
700508003439	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
700508003440	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
700508003441	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
700508003442	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
700508003443	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
700508003444	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
700508003445	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
700508003446	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
700508003447	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
700508003448	putative translocon binding site; other site
700508003449	protein-rRNA interface [nucleotide binding]; other site
700508003450	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
700508003451	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
700508003452	G-X-X-G motif; other site
700508003453	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
700508003454	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
700508003455	23S rRNA interface [nucleotide binding]; other site
700508003456	5S rRNA interface [nucleotide binding]; other site
700508003457	putative antibiotic binding site [chemical binding]; other site
700508003458	L25 interface [polypeptide binding]; other site
700508003459	L27 interface [polypeptide binding]; other site
700508003460	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
700508003461	L23 interface [polypeptide binding]; other site
700508003462	signal recognition particle (SRP54) interaction site; other site
700508003463	trigger factor interaction site; other site
700508003464	23S rRNA interface [nucleotide binding]; other site
700508003465	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
700508003466	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
700508003467	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
700508003468	DXD motif; other site
700508003469	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700508003470	Sulfatase; Region: Sulfatase; pfam00884
700508003471	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
700508003472	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700508003473	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508003474	putative substrate translocation pore; other site
700508003475	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508003476	Domain of unknown function (DUF336); Region: DUF336; pfam03928
700508003477	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
700508003478	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
700508003479	iron-sulfur cluster [ion binding]; other site
700508003480	[2Fe-2S] cluster binding site [ion binding]; other site
700508003481	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
700508003482	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
700508003483	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508003484	NAD(P) binding site [chemical binding]; other site
700508003485	catalytic residues [active]
700508003486	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
700508003487	[2Fe-2S] cluster binding site [ion binding]; other site
700508003488	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
700508003489	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
700508003490	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
700508003491	homotrimer interaction site [polypeptide binding]; other site
700508003492	putative active site [active]
700508003493	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
700508003494	Amidase; Region: Amidase; cl11426
700508003495	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
700508003496	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
700508003497	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
700508003498	RNA binding site [nucleotide binding]; other site
700508003499	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
700508003500	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
700508003501	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
700508003502	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
700508003503	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
700508003504	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
700508003505	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
700508003506	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
700508003507	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
700508003508	5S rRNA interface [nucleotide binding]; other site
700508003509	L27 interface [polypeptide binding]; other site
700508003510	23S rRNA interface [nucleotide binding]; other site
700508003511	L5 interface [polypeptide binding]; other site
700508003512	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
700508003513	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
700508003514	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
700508003515	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
700508003516	23S rRNA binding site [nucleotide binding]; other site
700508003517	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
700508003518	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
700508003519	tandem repeat interface [polypeptide binding]; other site
700508003520	oligomer interface [polypeptide binding]; other site
700508003521	active site residues [active]
700508003522	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
700508003523	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
700508003524	tandem repeat interface [polypeptide binding]; other site
700508003525	oligomer interface [polypeptide binding]; other site
700508003526	active site residues [active]
700508003527	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508003528	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508003529	DNA binding residues [nucleotide binding]
700508003530	dimerization interface [polypeptide binding]; other site
700508003531	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508003532	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508003533	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
700508003534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508003535	S-adenosylmethionine binding site [chemical binding]; other site
700508003536	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700508003537	active site
700508003538	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
700508003539	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
700508003540	putative ADP-binding pocket [chemical binding]; other site
700508003541	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508003542	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508003543	anti sigma factor interaction site; other site
700508003544	regulatory phosphorylation site [posttranslational modification]; other site
700508003545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508003546	metabolite-proton symporter; Region: 2A0106; TIGR00883
700508003547	putative substrate translocation pore; other site
700508003548	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700508003549	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
700508003550	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700508003551	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
700508003552	MspA; Region: MspA; pfam09203
700508003553	MspA; Region: MspA; pfam09203
700508003554	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
700508003555	SecY translocase; Region: SecY; pfam00344
700508003556	adenylate kinase; Reviewed; Region: adk; PRK00279
700508003557	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
700508003558	AMP-binding site [chemical binding]; other site
700508003559	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
700508003560	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
700508003561	active site
700508003562	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508003563	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508003564	DNA-binding site [nucleotide binding]; DNA binding site
700508003565	FCD domain; Region: FCD; cl11656
700508003566	choline dehydrogenase; Validated; Region: PRK02106
700508003567	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700508003568	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508003569	MarR family; Region: MarR; pfam01047
700508003570	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508003571	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700508003572	Histidine kinase; Region: HisKA_3; pfam07730
700508003573	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700508003574	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508003575	ATP binding site [chemical binding]; other site
700508003576	Mg2+ binding site [ion binding]; other site
700508003577	G-X-G motif; other site
700508003578	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508003579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508003580	active site
700508003581	phosphorylation site [posttranslational modification]
700508003582	intermolecular recognition site; other site
700508003583	dimerization interface [polypeptide binding]; other site
700508003584	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508003585	DNA binding residues [nucleotide binding]
700508003586	dimerization interface [polypeptide binding]; other site
700508003587	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
700508003588	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
700508003589	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700508003590	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
700508003591	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508003592	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508003593	active site
700508003594	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
700508003595	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
700508003596	tetrameric interface [polypeptide binding]; other site
700508003597	NAD binding site [chemical binding]; other site
700508003598	catalytic residues [active]
700508003599	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
700508003600	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
700508003601	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
700508003602	NAD binding site [chemical binding]; other site
700508003603	substrate binding site [chemical binding]; other site
700508003604	homodimer interface [polypeptide binding]; other site
700508003605	active site
700508003606	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
700508003607	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
700508003608	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
700508003609	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
700508003610	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700508003611	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700508003612	ligand binding site [chemical binding]; other site
700508003613	flexible hinge region; other site
700508003614	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508003615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508003616	ATP binding site [chemical binding]; other site
700508003617	Mg2+ binding site [ion binding]; other site
700508003618	G-X-G motif; other site
700508003619	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700508003620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508003621	active site
700508003622	phosphorylation site [posttranslational modification]
700508003623	intermolecular recognition site; other site
700508003624	dimerization interface [polypeptide binding]; other site
700508003625	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
700508003626	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508003627	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700508003628	hydrophobic ligand binding site; other site
700508003629	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508003630	Ligand Binding Site [chemical binding]; other site
700508003631	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508003632	Ligand Binding Site [chemical binding]; other site
700508003633	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508003634	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
700508003635	rRNA binding site [nucleotide binding]; other site
700508003636	predicted 30S ribosome binding site; other site
700508003637	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
700508003638	30S ribosomal protein S13; Region: bact_S13; TIGR03631
700508003639	30S ribosomal protein S11; Validated; Region: PRK05309
700508003640	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
700508003641	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
700508003642	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700508003643	RNA binding surface [nucleotide binding]; other site
700508003644	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
700508003645	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
700508003646	alphaNTD homodimer interface [polypeptide binding]; other site
700508003647	alphaNTD - beta interaction site [polypeptide binding]; other site
700508003648	alphaNTD - beta' interaction site [polypeptide binding]; other site
700508003649	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
700508003650	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
700508003651	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
700508003652	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
700508003653	dimerization interface 3.5A [polypeptide binding]; other site
700508003654	active site
700508003655	Cutinase; Region: Cutinase; pfam01083
700508003656	Cutinase; Region: Cutinase; pfam01083
700508003657	Cutinase; Region: Cutinase; pfam01083
700508003658	Cutinase; Region: Cutinase; pfam01083
700508003659	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
700508003660	EamA-like transporter family; Region: EamA; pfam00892
700508003661	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
700508003662	CGNR zinc finger; Region: zf-CGNR; pfam11706
700508003663	Uncharacterized conserved protein [Function unknown]; Region: COG3268
700508003664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508003665	NAD(P) binding site [chemical binding]; other site
700508003666	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508003667	Uncharacterized conserved protein [Function unknown]; Region: COG3349
700508003668	cyclase homology domain; Region: CHD; cd07302
700508003669	nucleotidyl binding site; other site
700508003670	metal binding site [ion binding]; metal-binding site
700508003671	dimer interface [polypeptide binding]; other site
700508003672	AAA ATPase domain; Region: AAA_16; pfam13191
700508003673	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
700508003674	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
700508003675	substrate binding pocket [chemical binding]; other site
700508003676	chain length determination region; other site
700508003677	substrate-Mg2+ binding site; other site
700508003678	catalytic residues [active]
700508003679	aspartate-rich region 1; other site
700508003680	active site lid residues [active]
700508003681	aspartate-rich region 2; other site
700508003682	Protein of unknown function (DUF690); Region: DUF690; cl04939
700508003683	Protein of unknown function (DUF690); Region: DUF690; cl04939
700508003684	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
700508003685	catalytic residues [active]
700508003686	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
700508003687	catalytic residues [active]
700508003688	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
700508003689	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
700508003690	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700508003691	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
700508003692	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700508003693	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700508003694	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
700508003695	Proteins of 100 residues with WXG; Region: WXG100; cl02005
700508003696	Proteins of 100 residues with WXG; Region: WXG100; cl02005
700508003697	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
700508003698	DNA binding site [nucleotide binding]
700508003699	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
700508003700	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508003701	NAD(P) binding site [chemical binding]; other site
700508003702	catalytic residues [active]
700508003703	glycerol kinase; Provisional; Region: glpK; PRK00047
700508003704	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
700508003705	N- and C-terminal domain interface [polypeptide binding]; other site
700508003706	active site
700508003707	MgATP binding site [chemical binding]; other site
700508003708	catalytic site [active]
700508003709	metal binding site [ion binding]; metal-binding site
700508003710	putative homotetramer interface [polypeptide binding]; other site
700508003711	glycerol binding site [chemical binding]; other site
700508003712	homodimer interface [polypeptide binding]; other site
700508003713	Domain of unknown function (DUF336); Region: DUF336; pfam03928
700508003714	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
700508003715	amphipathic channel; other site
700508003716	Asn-Pro-Ala signature motifs; other site
700508003717	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
700508003718	OsmC-like protein; Region: OsmC; cl00767
700508003719	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
700508003720	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
700508003721	active site
700508003722	SAM binding site [chemical binding]; other site
700508003723	homodimer interface [polypeptide binding]; other site
700508003724	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508003725	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508003726	DNA binding residues [nucleotide binding]
700508003727	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
700508003728	Dehydratase small subunit; Region: Dehydratase_SU; pfam02287
700508003729	propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444
700508003730	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
700508003731	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
700508003732	alpha-beta subunit interface [polypeptide binding]; other site
700508003733	alpha-gamma subunit interface [polypeptide binding]; other site
700508003734	active site
700508003735	substrate and K+ binding site; other site
700508003736	K+ binding site [ion binding]; other site
700508003737	cobalamin binding site [chemical binding]; other site
700508003738	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
700508003739	Cell division protein FtsA; Region: FtsA; cl17206
700508003740	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
700508003741	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
700508003742	Dehydratase medium subunit; Region: Dehydratase_MU; cl17703
700508003743	ethanolamine permease; Region: 2A0305; TIGR00908
700508003744	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
700508003745	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
700508003746	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
700508003747	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700508003748	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
700508003749	23S rRNA interface [nucleotide binding]; other site
700508003750	L3 interface [polypeptide binding]; other site
700508003751	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
700508003752	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
700508003753	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
700508003754	active site
700508003755	substrate binding site [chemical binding]; other site
700508003756	metal binding site [ion binding]; metal-binding site
700508003757	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
700508003758	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700508003759	ATP binding site [chemical binding]; other site
700508003760	Mg++ binding site [ion binding]; other site
700508003761	motif III; other site
700508003762	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508003763	nucleotide binding region [chemical binding]; other site
700508003764	ATP-binding site [chemical binding]; other site
700508003765	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
700508003766	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508003767	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
700508003768	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
700508003769	glutaminase active site [active]
700508003770	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
700508003771	dimer interface [polypeptide binding]; other site
700508003772	active site
700508003773	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
700508003774	dimer interface [polypeptide binding]; other site
700508003775	active site
700508003776	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508003777	Predicted transcriptional regulators [Transcription]; Region: COG1733
700508003778	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508003779	dimerization interface [polypeptide binding]; other site
700508003780	putative DNA binding site [nucleotide binding]; other site
700508003781	putative Zn2+ binding site [ion binding]; other site
700508003782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700508003783	PAS domain; Region: PAS_9; pfam13426
700508003784	putative active site [active]
700508003785	heme pocket [chemical binding]; other site
700508003786	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700508003787	cyanate hydratase; Validated; Region: PRK02866
700508003788	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
700508003789	oligomer interface [polypeptide binding]; other site
700508003790	active site
700508003791	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
700508003792	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508003793	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508003794	active site
700508003795	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700508003796	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700508003797	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700508003798	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
700508003799	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
700508003800	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
700508003801	active site
700508003802	P-loop; other site
700508003803	phosphorylation site [posttranslational modification]
700508003804	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
700508003805	active site
700508003806	phosphorylation site [posttranslational modification]
700508003807	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700508003808	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
700508003809	putative NAD(P) binding site [chemical binding]; other site
700508003810	catalytic Zn binding site [ion binding]; other site
700508003811	Uncharacterized conserved protein [Function unknown]; Region: COG0062
700508003812	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
700508003813	putative substrate binding site [chemical binding]; other site
700508003814	putative ATP binding site [chemical binding]; other site
700508003815	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508003816	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
700508003817	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508003818	catalytic residue [active]
700508003819	alanine racemase; Reviewed; Region: alr; PRK00053
700508003820	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
700508003821	active site
700508003822	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700508003823	dimer interface [polypeptide binding]; other site
700508003824	substrate binding site [chemical binding]; other site
700508003825	catalytic residues [active]
700508003826	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508003827	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508003828	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700508003829	TAP-like protein; Region: Abhydrolase_4; pfam08386
700508003830	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
700508003831	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
700508003832	Glycoprotease family; Region: Peptidase_M22; pfam00814
700508003833	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
700508003834	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508003835	Coenzyme A binding pocket [chemical binding]; other site
700508003836	UGMP family protein; Validated; Region: PRK09604
700508003837	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
700508003838	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
700508003839	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508003840	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
700508003841	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cl12104
700508003842	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
700508003843	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
700508003844	alpha-beta subunit interface [polypeptide binding]; other site
700508003845	alpha-gamma subunit interface [polypeptide binding]; other site
700508003846	active site
700508003847	substrate and K+ binding site; other site
700508003848	K+ binding site [ion binding]; other site
700508003849	cobalamin binding site [chemical binding]; other site
700508003850	Dehydratase medium subunit; Region: Dehydratase_MU; cl17703
700508003851	propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443
700508003852	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
700508003853	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
700508003854	oligomerisation interface [polypeptide binding]; other site
700508003855	mobile loop; other site
700508003856	roof hairpin; other site
700508003857	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
700508003858	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
700508003859	ring oligomerisation interface [polypeptide binding]; other site
700508003860	ATP/Mg binding site [chemical binding]; other site
700508003861	stacking interactions; other site
700508003862	hinge regions; other site
700508003863	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
700508003864	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508003865	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
700508003866	active site
700508003867	Transcription factor WhiB; Region: Whib; pfam02467
700508003868	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700508003869	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508003870	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508003871	DNA binding residues [nucleotide binding]
700508003872	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
700508003873	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
700508003874	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
700508003875	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
700508003876	active site
700508003877	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
700508003878	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
700508003879	active site
700508003880	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
700508003881	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508003882	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700508003883	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
700508003884	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
700508003885	tetramer interface [polypeptide binding]; other site
700508003886	heme binding pocket [chemical binding]; other site
700508003887	NADPH binding site [chemical binding]; other site
700508003888	hypothetical protein; Validated; Region: PRK07198
700508003889	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
700508003890	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
700508003891	dimerization interface [polypeptide binding]; other site
700508003892	active site
700508003893	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
700508003894	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700508003895	active site
700508003896	GMP synthase; Reviewed; Region: guaA; PRK00074
700508003897	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
700508003898	AMP/PPi binding site [chemical binding]; other site
700508003899	candidate oxyanion hole; other site
700508003900	catalytic triad [active]
700508003901	potential glutamine specificity residues [chemical binding]; other site
700508003902	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
700508003903	ATP Binding subdomain [chemical binding]; other site
700508003904	Ligand Binding sites [chemical binding]; other site
700508003905	Dimerization subdomain; other site
700508003906	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
700508003907	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508003908	DNA binding residues [nucleotide binding]
700508003909	putative dimer interface [polypeptide binding]; other site
700508003910	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508003911	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
700508003912	Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; pfam09286
700508003913	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
700508003914	active site
700508003915	catalytic triad [active]
700508003916	calcium binding site [ion binding]; other site
700508003917	DNA Polymerase Y-family; Region: PolY_like; cd03468
700508003918	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
700508003919	DNA binding site [nucleotide binding]
700508003920	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
700508003921	active site
700508003922	short chain dehydrogenase; Provisional; Region: PRK07201
700508003923	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
700508003924	putative NAD(P) binding site [chemical binding]; other site
700508003925	active site
700508003926	putative substrate binding site [chemical binding]; other site
700508003927	classical (c) SDRs; Region: SDR_c; cd05233
700508003928	NAD(P) binding site [chemical binding]; other site
700508003929	active site
700508003930	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
700508003931	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508003932	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
700508003933	TAP-like protein; Region: Abhydrolase_4; pfam08386
700508003934	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700508003935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508003936	S-adenosylmethionine binding site [chemical binding]; other site
700508003937	Leucine carboxyl methyltransferase; Region: LCM; cl01306
700508003938	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
700508003939	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
700508003940	DNA binding residues [nucleotide binding]
700508003941	dimer interface [polypeptide binding]; other site
700508003942	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
700508003943	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
700508003944	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
700508003945	intersubunit interface [polypeptide binding]; other site
700508003946	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
700508003947	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
700508003948	ABC-ATPase subunit  interface; other site
700508003949	dimer interface [polypeptide binding]; other site
700508003950	putative PBP binding regions; other site
700508003951	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
700508003952	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
700508003953	Walker A/P-loop; other site
700508003954	ATP binding site [chemical binding]; other site
700508003955	Q-loop/lid; other site
700508003956	ABC transporter signature motif; other site
700508003957	Walker B; other site
700508003958	D-loop; other site
700508003959	H-loop/switch region; other site
700508003960	multidrug resistance protein MdtH; Provisional; Region: PRK11646
700508003961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
700508003962	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508003963	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508003964	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508003965	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
700508003966	putative heme binding pocket [chemical binding]; other site
700508003967	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
700508003968	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
700508003969	molybdopterin cofactor binding site; other site
700508003970	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
700508003971	molybdopterin cofactor binding site; other site
700508003972	Ferredoxin [Energy production and conversion]; Region: COG1146
700508003973	4Fe-4S binding domain; Region: Fer4; pfam00037
700508003974	ferredoxin-NADP+ reductase; Region: PLN02852
700508003975	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508003976	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
700508003977	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
700508003978	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508003979	active site
700508003980	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
700508003981	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
700508003982	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
700508003983	PYR/PP interface [polypeptide binding]; other site
700508003984	dimer interface [polypeptide binding]; other site
700508003985	TPP binding site [chemical binding]; other site
700508003986	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
700508003987	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
700508003988	TPP-binding site; other site
700508003989	dimer interface [polypeptide binding]; other site
700508003990	hypothetical protein; Provisional; Region: PRK06126
700508003991	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508003992	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
700508003993	active site
700508003994	metal binding site [ion binding]; metal-binding site
700508003995	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508003996	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
700508003997	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
700508003998	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
700508003999	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
700508004000	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508004001	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700508004002	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
700508004003	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508004004	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700508004005	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700508004006	active site residue [active]
700508004007	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700508004008	active site residue [active]
700508004009	Sulphur transport; Region: Sulf_transp; pfam04143
700508004010	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
700508004011	putative homotetramer interface [polypeptide binding]; other site
700508004012	putative homodimer interface [polypeptide binding]; other site
700508004013	putative allosteric switch controlling residues; other site
700508004014	putative metal binding site [ion binding]; other site
700508004015	putative homodimer-homodimer interface [polypeptide binding]; other site
700508004016	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508004017	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508004018	enoyl-CoA hydratase; Region: PLN02864
700508004019	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508004020	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
700508004021	dimer interaction site [polypeptide binding]; other site
700508004022	substrate-binding tunnel; other site
700508004023	active site
700508004024	catalytic site [active]
700508004025	substrate binding site [chemical binding]; other site
700508004026	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
700508004027	Ligand Binding Site [chemical binding]; other site
700508004028	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508004029	Ligand Binding Site [chemical binding]; other site
700508004030	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
700508004031	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
700508004032	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
700508004033	active site
700508004034	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
700508004035	generic binding surface II; other site
700508004036	generic binding surface I; other site
700508004037	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
700508004038	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
700508004039	FMN binding site [chemical binding]; other site
700508004040	dimer interface [polypeptide binding]; other site
700508004041	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
700508004042	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700508004043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508004044	S-adenosylmethionine binding site [chemical binding]; other site
700508004045	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508004046	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
700508004047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508004048	ATP binding site [chemical binding]; other site
700508004049	Mg2+ binding site [ion binding]; other site
700508004050	G-X-G motif; other site
700508004051	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
700508004052	Protein of unknown function (DUF742); Region: DUF742; pfam05331
700508004053	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
700508004054	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
700508004055	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
700508004056	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700508004057	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700508004058	phosphopeptide binding site; other site
700508004059	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700508004060	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700508004061	phosphopeptide binding site; other site
700508004062	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700508004063	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
700508004064	Walker A/P-loop; other site
700508004065	ATP binding site [chemical binding]; other site
700508004066	Q-loop/lid; other site
700508004067	ABC transporter signature motif; other site
700508004068	Walker B; other site
700508004069	D-loop; other site
700508004070	H-loop/switch region; other site
700508004071	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700508004072	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
700508004073	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700508004074	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
700508004075	active site
700508004076	FMN binding site [chemical binding]; other site
700508004077	substrate binding site [chemical binding]; other site
700508004078	putative catalytic residue [active]
700508004079	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
700508004080	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
700508004081	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
700508004082	homodimer interface [polypeptide binding]; other site
700508004083	NADP binding site [chemical binding]; other site
700508004084	substrate binding site [chemical binding]; other site
700508004085	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
700508004086	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700508004087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508004088	S-adenosylmethionine binding site [chemical binding]; other site
700508004089	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
700508004090	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
700508004091	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
700508004092	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
700508004093	homodimer interface [polypeptide binding]; other site
700508004094	substrate-cofactor binding pocket; other site
700508004095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508004096	catalytic residue [active]
700508004097	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
700508004098	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
700508004099	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508004100	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
700508004101	putative catalytic site [active]
700508004102	putative metal binding site [ion binding]; other site
700508004103	putative phosphate binding site [ion binding]; other site
700508004104	Putative serine esterase (DUF676); Region: DUF676; pfam05057
700508004105	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
700508004106	active site
700508004107	HIGH motif; other site
700508004108	dimer interface [polypeptide binding]; other site
700508004109	KMSKS motif; other site
700508004110	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
700508004111	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
700508004112	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700508004113	FMN binding site [chemical binding]; other site
700508004114	substrate binding site [chemical binding]; other site
700508004115	putative catalytic residue [active]
700508004116	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
700508004117	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
700508004118	hypothetical protein; Provisional; Region: PRK06541
700508004119	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508004120	inhibitor-cofactor binding pocket; inhibition site
700508004121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508004122	catalytic residue [active]
700508004123	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700508004124	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
700508004125	AsnC family; Region: AsnC_trans_reg; pfam01037
700508004126	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
700508004127	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
700508004128	NAD(P) binding site [chemical binding]; other site
700508004129	catalytic residues [active]
700508004130	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508004131	Ligand Binding Site [chemical binding]; other site
700508004132	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508004133	Ligand Binding Site [chemical binding]; other site
700508004134	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
700508004135	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
700508004136	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508004137	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700508004138	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
700508004139	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
700508004140	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
700508004141	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
700508004142	L-aspartate oxidase; Provisional; Region: PRK06175
700508004143	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
700508004144	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
700508004145	putative Iron-sulfur protein interface [polypeptide binding]; other site
700508004146	putative proximal heme binding site [chemical binding]; other site
700508004147	putative SdhC-like subunit interface [polypeptide binding]; other site
700508004148	putative distal heme binding site [chemical binding]; other site
700508004149	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
700508004150	putative Iron-sulfur protein interface [polypeptide binding]; other site
700508004151	putative proximal heme binding site [chemical binding]; other site
700508004152	putative SdhD-like interface [polypeptide binding]; other site
700508004153	putative distal heme binding site [chemical binding]; other site
700508004154	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
700508004155	active site
700508004156	catalytic motif [active]
700508004157	Zn binding site [ion binding]; other site
700508004158	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
700508004159	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
700508004160	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
700508004161	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
700508004162	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
700508004163	adenosine deaminase; Provisional; Region: PRK09358
700508004164	active site
700508004165	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
700508004166	NlpC/P60 family; Region: NLPC_P60; pfam00877
700508004167	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700508004168	active site
700508004169	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
700508004170	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
700508004171	active site
700508004172	substrate binding site [chemical binding]; other site
700508004173	metal binding site [ion binding]; metal-binding site
700508004174	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508004175	MarR family; Region: MarR_2; pfam12802
700508004176	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004177	purine nucleoside phosphorylase; Provisional; Region: PRK08202
700508004178	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
700508004179	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
700508004180	metal binding site [ion binding]; metal-binding site
700508004181	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
700508004182	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
700508004183	metal binding site [ion binding]; metal-binding site
700508004184	putative dimer interface [polypeptide binding]; other site
700508004185	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
700508004186	putative active site pocket [active]
700508004187	dimerization interface [polypeptide binding]; other site
700508004188	putative catalytic residue [active]
700508004189	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
700508004190	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508004191	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508004192	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
700508004193	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
700508004194	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
700508004195	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
700508004196	active site
700508004197	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700508004198	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
700508004199	classical (c) SDRs; Region: SDR_c; cd05233
700508004200	NAD(P) binding site [chemical binding]; other site
700508004201	active site
700508004202	enoyl-CoA hydratase; Provisional; Region: PRK05864
700508004203	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508004204	substrate binding site [chemical binding]; other site
700508004205	oxyanion hole (OAH) forming residues; other site
700508004206	trimer interface [polypeptide binding]; other site
700508004207	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
700508004208	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004209	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
700508004210	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700508004211	FAD binding pocket [chemical binding]; other site
700508004212	FAD binding motif [chemical binding]; other site
700508004213	phosphate binding motif [ion binding]; other site
700508004214	beta-alpha-beta structure motif; other site
700508004215	NAD binding pocket [chemical binding]; other site
700508004216	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508004217	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
700508004218	catalytic loop [active]
700508004219	iron binding site [ion binding]; other site
700508004220	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
700508004221	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
700508004222	putative di-iron ligands [ion binding]; other site
700508004223	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
700508004224	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
700508004225	putative DNA binding site [nucleotide binding]; other site
700508004226	catalytic residue [active]
700508004227	putative H2TH interface [polypeptide binding]; other site
700508004228	putative catalytic residues [active]
700508004229	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
700508004230	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
700508004231	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508004232	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
700508004233	ATP binding site [chemical binding]; other site
700508004234	putative Mg++ binding site [ion binding]; other site
700508004235	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508004236	nucleotide binding region [chemical binding]; other site
700508004237	ATP-binding site [chemical binding]; other site
700508004238	DEAD/H associated; Region: DEAD_assoc; pfam08494
700508004239	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
700508004240	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
700508004241	classical (c) SDRs; Region: SDR_c; cd05233
700508004242	NAD(P) binding site [chemical binding]; other site
700508004243	active site
700508004244	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508004245	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508004246	active site
700508004247	heat shock protein 90; Provisional; Region: PRK05218
700508004248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508004249	ATP binding site [chemical binding]; other site
700508004250	Mg2+ binding site [ion binding]; other site
700508004251	G-X-G motif; other site
700508004252	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
700508004253	aldehyde dehydrogenase family 7 member; Region: PLN02315
700508004254	tetrameric interface [polypeptide binding]; other site
700508004255	NAD binding site [chemical binding]; other site
700508004256	catalytic residues [active]
700508004257	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
700508004258	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
700508004259	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
700508004260	AsnC family; Region: AsnC_trans_reg; pfam01037
700508004261	L-lysine aminotransferase; Provisional; Region: PRK08297
700508004262	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508004263	inhibitor-cofactor binding pocket; inhibition site
700508004264	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508004265	catalytic residue [active]
700508004266	Restriction endonuclease; Region: Mrr_cat; pfam04471
700508004267	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700508004268	hydrophobic ligand binding site; other site
700508004269	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508004270	dimerization interface [polypeptide binding]; other site
700508004271	putative DNA binding site [nucleotide binding]; other site
700508004272	putative Zn2+ binding site [ion binding]; other site
700508004273	PAS fold; Region: PAS_3; pfam08447
700508004274	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
700508004275	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
700508004276	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508004277	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700508004278	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
700508004279	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508004280	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
700508004281	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508004282	DNA binding residues [nucleotide binding]
700508004283	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508004284	anti sigma factor interaction site; other site
700508004285	regulatory phosphorylation site [posttranslational modification]; other site
700508004286	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
700508004287	metal-binding site
700508004288	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
700508004289	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700508004290	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
700508004291	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
700508004292	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700508004293	carboxyltransferase (CT) interaction site; other site
700508004294	biotinylation site [posttranslational modification]; other site
700508004295	Fe-S metabolism associated domain; Region: SufE; cl00951
700508004296	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
700508004297	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
700508004298	active site residue [active]
700508004299	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
700508004300	active site residue [active]
700508004301	Isochorismatase family; Region: Isochorismatase; pfam00857
700508004302	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
700508004303	catalytic triad [active]
700508004304	conserved cis-peptide bond; other site
700508004305	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
700508004306	Maf-like protein; Region: Maf; pfam02545
700508004307	putative active site [active]
700508004308	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
700508004309	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
700508004310	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
700508004311	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
700508004312	acyl-CoA synthetase; Provisional; Region: PRK13388
700508004313	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508004314	acyl-activating enzyme (AAE) consensus motif; other site
700508004315	AMP binding site [chemical binding]; other site
700508004316	active site
700508004317	CoA binding site [chemical binding]; other site
700508004318	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
700508004319	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
700508004320	iron-sulfur cluster [ion binding]; other site
700508004321	[2Fe-2S] cluster binding site [ion binding]; other site
700508004322	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
700508004323	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508004324	putative ADP-binding pocket [chemical binding]; other site
700508004325	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
700508004326	trimer interface [polypeptide binding]; other site
700508004327	active site
700508004328	substrate binding site [chemical binding]; other site
700508004329	CoA binding site [chemical binding]; other site
700508004330	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508004331	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700508004332	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
700508004333	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
700508004334	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
700508004335	Chain length determinant protein; Region: Wzz; pfam02706
700508004336	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
700508004337	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700508004338	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700508004339	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508004340	Chain length determinant protein; Region: Wzz; cl15801
700508004341	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508004342	Secretory lipase; Region: LIP; pfam03583
700508004343	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700508004344	Secretory lipase; Region: LIP; pfam03583
700508004345	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
700508004346	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700508004347	Secretory lipase; Region: LIP; pfam03583
700508004348	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
700508004349	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
700508004350	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
700508004351	Bacterial PH domain; Region: DUF304; pfam03703
700508004352	Predicted membrane protein [Function unknown]; Region: COG2246
700508004353	GtrA-like protein; Region: GtrA; pfam04138
700508004354	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
700508004355	ATP-grasp domain; Region: ATP-grasp; pfam02222
700508004356	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
700508004357	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508004358	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508004359	active site
700508004360	Methyltransferase domain; Region: Methyltransf_24; pfam13578
700508004361	TIGR03089 family protein; Region: TIGR03089
700508004362	Transcriptional regulator [Transcription]; Region: LytR; COG1316
700508004363	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
700508004364	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
700508004365	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
700508004366	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
700508004367	NADP binding site [chemical binding]; other site
700508004368	active site
700508004369	putative substrate binding site [chemical binding]; other site
700508004370	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
700508004371	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
700508004372	Probable Catalytic site; other site
700508004373	metal-binding site
700508004374	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
700508004375	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
700508004376	active site
700508004377	Substrate binding site; other site
700508004378	Mg++ binding site; other site
700508004379	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
700508004380	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
700508004381	nudix motif; other site
700508004382	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
700508004383	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
700508004384	F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553
700508004385	FMN binding site [chemical binding]; other site
700508004386	dimer interface [polypeptide binding]; other site
700508004387	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
700508004388	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
700508004389	phosphate binding site [ion binding]; other site
700508004390	dimer interface [polypeptide binding]; other site
700508004391	substrate binding site [chemical binding]; other site
700508004392	Transcription factor WhiB; Region: Whib; pfam02467
700508004393	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
700508004394	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
700508004395	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
700508004396	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
700508004397	active site
700508004398	substrate binding site [chemical binding]; other site
700508004399	metal binding site [ion binding]; metal-binding site
700508004400	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
700508004401	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
700508004402	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
700508004403	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
700508004404	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700508004405	Di-iron ligands [ion binding]; other site
700508004406	Rubredoxin [Energy production and conversion]; Region: COG1773
700508004407	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
700508004408	iron binding site [ion binding]; other site
700508004409	Rubredoxin [Energy production and conversion]; Region: COG1773
700508004410	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
700508004411	iron binding site [ion binding]; other site
700508004412	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508004413	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508004415	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
700508004416	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
700508004417	homotetramer interface [polypeptide binding]; other site
700508004418	ligand binding site [chemical binding]; other site
700508004419	catalytic site [active]
700508004420	NAD binding site [chemical binding]; other site
700508004421	Secretory lipase; Region: LIP; pfam03583
700508004422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700508004423	TPR motif; other site
700508004424	binding surface
700508004425	TPR repeat; Region: TPR_11; pfam13414
700508004426	TPR repeat; Region: TPR_11; pfam13414
700508004427	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
700508004428	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
700508004429	TMP-binding site; other site
700508004430	ATP-binding site [chemical binding]; other site
700508004431	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508004432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508004433	active site
700508004434	phosphorylation site [posttranslational modification]
700508004435	intermolecular recognition site; other site
700508004436	dimerization interface [polypeptide binding]; other site
700508004437	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508004438	DNA binding site [nucleotide binding]
700508004439	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508004440	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700508004441	dimerization interface [polypeptide binding]; other site
700508004442	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508004443	dimer interface [polypeptide binding]; other site
700508004444	phosphorylation site [posttranslational modification]
700508004445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508004446	ATP binding site [chemical binding]; other site
700508004447	Mg2+ binding site [ion binding]; other site
700508004448	G-X-G motif; other site
700508004449	lipoprotein LpqB; Provisional; Region: PRK13616
700508004450	Sporulation and spore germination; Region: Germane; pfam10646
700508004451	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
700508004452	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
700508004453	30S subunit binding site; other site
700508004454	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
700508004455	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
700508004456	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508004457	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
700508004458	BCCT family transporter; Region: BCCT; pfam02028
700508004459	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
700508004460	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700508004461	FAD binding pocket [chemical binding]; other site
700508004462	FAD binding motif [chemical binding]; other site
700508004463	phosphate binding motif [ion binding]; other site
700508004464	beta-alpha-beta structure motif; other site
700508004465	NAD binding pocket [chemical binding]; other site
700508004466	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
700508004467	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508004468	catalytic loop [active]
700508004469	iron binding site [ion binding]; other site
700508004470	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
700508004471	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
700508004472	putative di-iron ligands [ion binding]; other site
700508004473	Predicted GTPases [General function prediction only]; Region: COG1162
700508004474	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
700508004475	GTPase/Zn-binding domain interface [polypeptide binding]; other site
700508004476	GTP/Mg2+ binding site [chemical binding]; other site
700508004477	G4 box; other site
700508004478	G5 box; other site
700508004479	G1 box; other site
700508004480	Switch I region; other site
700508004481	G2 box; other site
700508004482	G3 box; other site
700508004483	Switch II region; other site
700508004484	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
700508004485	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
700508004486	hinge; other site
700508004487	active site
700508004488	Uncharacterized conserved protein [Function unknown]; Region: COG2135
700508004489	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
700508004490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508004491	S-adenosylmethionine binding site [chemical binding]; other site
700508004492	Methyltransferase domain; Region: Methyltransf_11; pfam08241
700508004493	Predicted acetyltransferase [General function prediction only]; Region: COG2388
700508004494	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
700508004495	putative deacylase active site [active]
700508004496	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
700508004497	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508004498	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508004499	DNA binding residues [nucleotide binding]
700508004500	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
700508004501	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700508004502	carboxyltransferase (CT) interaction site; other site
700508004503	biotinylation site [posttranslational modification]; other site
700508004504	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
700508004505	PAS fold; Region: PAS_4; pfam08448
700508004506	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
700508004507	Histidine kinase; Region: HisKA_2; pfam07568
700508004508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508004509	ATP binding site [chemical binding]; other site
700508004510	Mg2+ binding site [ion binding]; other site
700508004511	G-X-G motif; other site
700508004512	Transcription factor WhiB; Region: Whib; pfam02467
700508004513	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
700508004514	hypothetical protein; Provisional; Region: PRK01842
700508004515	SEC-C motif; Region: SEC-C; pfam02810
700508004516	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508004517	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508004518	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508004519	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508004520	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508004521	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508004522	active site
700508004523	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508004524	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508004525	active site
700508004526	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
700508004527	Dehydroquinase class II; Region: DHquinase_II; pfam01220
700508004528	active site
700508004529	trimer interface [polypeptide binding]; other site
700508004530	dimer interface [polypeptide binding]; other site
700508004531	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700508004532	isochorismate synthase DhbC; Validated; Region: PRK06923
700508004533	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
700508004534	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508004535	catalytic core [active]
700508004536	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
700508004537	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700508004538	P-loop; other site
700508004539	Magnesium ion binding site [ion binding]; other site
700508004540	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
700508004541	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700508004542	Magnesium ion binding site [ion binding]; other site
700508004543	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
700508004544	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
700508004545	DEAD-like helicases superfamily; Region: DEXDc; smart00487
700508004546	ATP binding site [chemical binding]; other site
700508004547	Mg++ binding site [ion binding]; other site
700508004548	motif III; other site
700508004549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508004550	nucleotide binding region [chemical binding]; other site
700508004551	ATP-binding site [chemical binding]; other site
700508004552	hypothetical protein; Provisional; Region: PRK07236
700508004553	hypothetical protein; Validated; Region: PRK05868
700508004554	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
700508004555	dinuclear metal binding motif [ion binding]; other site
700508004556	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
700508004557	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508004558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004559	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
700508004560	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
700508004561	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
700508004562	ATP binding site [chemical binding]; other site
700508004563	substrate interface [chemical binding]; other site
700508004564	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
700508004565	active site residue [active]
700508004566	TIGR02569 family protein; Region: TIGR02569_actnb
700508004567	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
700508004568	active site
700508004569	DNA binding site [nucleotide binding]
700508004570	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508004571	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508004572	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
700508004573	catalytic site [active]
700508004574	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
700508004575	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
700508004576	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
700508004577	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
700508004578	Predicted membrane protein [Function unknown]; Region: COG4270
700508004579	Ion channel; Region: Ion_trans_2; pfam07885
700508004580	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
700508004581	TrkA-N domain; Region: TrkA_N; pfam02254
700508004582	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
700508004583	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
700508004584	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
700508004585	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
700508004586	putative NADH binding site [chemical binding]; other site
700508004587	putative active site [active]
700508004588	nudix motif; other site
700508004589	putative metal binding site [ion binding]; other site
700508004590	putative acyltransferase; Provisional; Region: PRK05790
700508004591	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508004592	dimer interface [polypeptide binding]; other site
700508004593	active site
700508004594	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
700508004595	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
700508004596	Transcriptional regulator [Transcription]; Region: IclR; COG1414
700508004597	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
700508004598	Bacterial transcriptional regulator; Region: IclR; pfam01614
700508004599	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
700508004600	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
700508004601	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
700508004602	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
700508004603	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
700508004604	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
700508004605	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
700508004606	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
700508004607	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
700508004608	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
700508004609	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
700508004610	catalytic residues [active]
700508004611	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
700508004612	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
700508004613	Family description; Region: UvrD_C_2; pfam13538
700508004614	HRDC domain; Region: HRDC; pfam00570
700508004615	Transcription factor WhiB; Region: Whib; pfam02467
700508004616	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
700508004617	ABC1 family; Region: ABC1; pfam03109
700508004618	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508004619	active site
700508004620	ATP binding site [chemical binding]; other site
700508004621	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
700508004622	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
700508004623	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
700508004624	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
700508004625	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700508004626	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
700508004627	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
700508004628	hypothetical protein; Validated; Region: PRK00068
700508004629	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700508004630	FAD binding domain; Region: FAD_binding_4; pfam01565
700508004631	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
700508004632	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
700508004633	Int/Topo IB signature motif; other site
700508004634	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508004635	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508004636	non-specific DNA binding site [nucleotide binding]; other site
700508004637	salt bridge; other site
700508004638	sequence-specific DNA binding site [nucleotide binding]; other site
700508004639	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
700508004640	TrwC relaxase; Region: TrwC; pfam08751
700508004641	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
700508004642	AAA domain; Region: AAA_30; pfam13604
700508004643	Family description; Region: UvrD_C_2; pfam13538
700508004644	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
700508004645	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
700508004646	TPR motif; other site
700508004647	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700508004648	binding surface
700508004649	Tetratricopeptide repeat; Region: TPR_12; pfam13424
700508004650	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
700508004651	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508004652	active site
700508004653	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700508004654	AAA ATPase domain; Region: AAA_15; pfam13175
700508004655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508004656	Walker A/P-loop; other site
700508004657	ATP binding site [chemical binding]; other site
700508004658	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
700508004659	putative active site [active]
700508004660	putative metal-binding site [ion binding]; other site
700508004661	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
700508004662	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
700508004663	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508004664	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
700508004665	active site
700508004666	metal binding site [ion binding]; metal-binding site
700508004667	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508004668	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004669	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
700508004670	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700508004671	putative NAD(P) binding site [chemical binding]; other site
700508004672	PE-PPE domain; Region: PE-PPE; pfam08237
700508004673	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
700508004674	nucleophilic elbow; other site
700508004675	catalytic triad; other site
700508004676	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
700508004677	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
700508004678	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508004679	active site
700508004680	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508004681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508004682	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
700508004683	putative dimerization interface [polypeptide binding]; other site
700508004684	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
700508004685	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
700508004686	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
700508004687	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508004688	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508004689	metal binding site [ion binding]; metal-binding site
700508004690	active site
700508004691	I-site; other site
700508004692	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
700508004693	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
700508004694	active site
700508004695	NAD binding site [chemical binding]; other site
700508004696	metal binding site [ion binding]; metal-binding site
700508004697	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
700508004698	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
700508004699	tetrameric interface [polypeptide binding]; other site
700508004700	NAD binding site [chemical binding]; other site
700508004701	catalytic residues [active]
700508004702	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508004703	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508004704	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
700508004705	dimerization interface [polypeptide binding]; other site
700508004706	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
700508004707	Na binding site [ion binding]; other site
700508004708	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
700508004709	Amidase; Region: Amidase; pfam01425
700508004710	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508004711	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508004712	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
700508004713	GAF domain; Region: GAF; pfam01590
700508004714	GAF domain; Region: GAF_2; pfam13185
700508004715	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
700508004716	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
700508004717	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700508004718	putative active site [active]
700508004719	putative metal binding site [ion binding]; other site
700508004720	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700508004721	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700508004722	DNA binding site [nucleotide binding]
700508004723	domain linker motif; other site
700508004724	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
700508004725	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
700508004726	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
700508004727	active site
700508004728	Zn binding site [ion binding]; other site
700508004729	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700508004730	hydrophobic ligand binding site; other site
700508004731	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
700508004732	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508004733	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
700508004734	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508004735	DNA binding residues [nucleotide binding]
700508004736	GAF domain; Region: GAF; cl17456
700508004737	GAF domain; Region: GAF_2; pfam13185
700508004738	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
700508004739	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508004740	anti sigma factor interaction site; other site
700508004741	regulatory phosphorylation site [posttranslational modification]; other site
700508004742	GAF domain; Region: GAF; pfam01590
700508004743	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508004744	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
700508004745	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700508004746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
700508004747	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508004748	anti sigma factor interaction site; other site
700508004749	regulatory phosphorylation site [posttranslational modification]; other site
700508004750	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508004751	GAF domain; Region: GAF_3; pfam13492
700508004752	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508004753	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508004754	dimer interface [polypeptide binding]; other site
700508004755	phosphorylation site [posttranslational modification]
700508004756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508004757	ATP binding site [chemical binding]; other site
700508004758	Mg2+ binding site [ion binding]; other site
700508004759	G-X-G motif; other site
700508004760	Response regulator receiver domain; Region: Response_reg; pfam00072
700508004761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508004762	active site
700508004763	phosphorylation site [posttranslational modification]
700508004764	intermolecular recognition site; other site
700508004765	dimerization interface [polypeptide binding]; other site
700508004766	PAS fold; Region: PAS_4; pfam08448
700508004767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700508004768	putative active site [active]
700508004769	heme pocket [chemical binding]; other site
700508004770	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
700508004771	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700508004772	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508004773	ATP binding site [chemical binding]; other site
700508004774	Mg2+ binding site [ion binding]; other site
700508004775	G-X-G motif; other site
700508004776	phosphoenolpyruvate synthase; Validated; Region: PRK06241
700508004777	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
700508004778	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
700508004779	ANTAR domain; Region: ANTAR; pfam03861
700508004780	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508004781	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508004782	metal binding site [ion binding]; metal-binding site
700508004783	active site
700508004784	I-site; other site
700508004785	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
700508004786	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
700508004787	classical (c) SDRs; Region: SDR_c; cd05233
700508004788	NAD(P) binding site [chemical binding]; other site
700508004789	active site
700508004790	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
700508004791	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
700508004792	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
700508004793	putative active site [active]
700508004794	putative metal binding site [ion binding]; other site
700508004795	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508004796	anti sigma factor interaction site; other site
700508004797	regulatory phosphorylation site [posttranslational modification]; other site
700508004798	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508004799	short chain dehydrogenase; Provisional; Region: PRK06701
700508004800	NAD(P) binding site [chemical binding]; other site
700508004801	active site
700508004802	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508004803	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508004804	active site
700508004805	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
700508004806	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
700508004807	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508004808	Walker A/P-loop; other site
700508004809	ATP binding site [chemical binding]; other site
700508004810	Q-loop/lid; other site
700508004811	ABC transporter signature motif; other site
700508004812	Walker B; other site
700508004813	D-loop; other site
700508004814	H-loop/switch region; other site
700508004815	TOBE domain; Region: TOBE; cl01440
700508004816	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
700508004817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508004818	dimer interface [polypeptide binding]; other site
700508004819	conserved gate region; other site
700508004820	putative PBP binding loops; other site
700508004821	ABC-ATPase subunit interface; other site
700508004822	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
700508004823	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
700508004824	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
700508004825	DNA binding residues [nucleotide binding]
700508004826	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508004827	TOBE domain; Region: TOBE; cl01440
700508004828	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508004829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004830	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
700508004831	Na binding site [ion binding]; other site
700508004832	putative glycosylation site [posttranslational modification]; other site
700508004833	putative glycosylation site [posttranslational modification]; other site
700508004834	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
700508004835	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
700508004836	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
700508004837	allophanate hydrolase; Provisional; Region: PRK08186
700508004838	Amidase; Region: Amidase; cl11426
700508004839	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700508004840	urea carboxylase; Region: urea_carbox; TIGR02712
700508004841	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508004842	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
700508004843	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
700508004844	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
700508004845	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700508004846	carboxyltransferase (CT) interaction site; other site
700508004847	biotinylation site [posttranslational modification]; other site
700508004848	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
700508004849	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
700508004850	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
700508004851	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
700508004852	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
700508004853	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508004854	acyl-activating enzyme (AAE) consensus motif; other site
700508004855	AMP binding site [chemical binding]; other site
700508004856	active site
700508004857	CoA binding site [chemical binding]; other site
700508004858	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508004859	Predicted acyl esterases [General function prediction only]; Region: COG2936
700508004860	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
700508004861	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700508004862	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
700508004863	NAD(P) binding site [chemical binding]; other site
700508004864	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
700508004865	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
700508004866	catalytic Zn binding site [ion binding]; other site
700508004867	NAD binding site [chemical binding]; other site
700508004868	structural Zn binding site [ion binding]; other site
700508004869	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508004870	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508004871	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
700508004872	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
700508004873	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508004874	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
700508004875	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508004876	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508004877	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508004878	Helix-turn-helix domain; Region: HTH_18; pfam12833
700508004879	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
700508004880	putative active site [active]
700508004881	putative substrate binding site [chemical binding]; other site
700508004882	ATP binding site [chemical binding]; other site
700508004883	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508004884	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004885	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508004886	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508004887	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
700508004888	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700508004889	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
700508004890	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700508004891	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
700508004892	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
700508004893	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700508004894	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
700508004895	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
700508004896	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
700508004897	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
700508004898	4Fe-4S binding domain; Region: Fer4; pfam00037
700508004899	4Fe-4S binding domain; Region: Fer4; pfam00037
700508004900	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
700508004901	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
700508004902	NADH dehydrogenase subunit G; Validated; Region: PRK07860
700508004903	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508004904	catalytic loop [active]
700508004905	iron binding site [ion binding]; other site
700508004906	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
700508004907	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
700508004908	molybdopterin cofactor binding site; other site
700508004909	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
700508004910	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
700508004911	SLBB domain; Region: SLBB; pfam10531
700508004912	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
700508004913	NADH dehydrogenase subunit E; Validated; Region: PRK07539
700508004914	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
700508004915	putative dimer interface [polypeptide binding]; other site
700508004916	[2Fe-2S] cluster binding site [ion binding]; other site
700508004917	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
700508004918	NADH dehydrogenase subunit D; Validated; Region: PRK06075
700508004919	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
700508004920	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
700508004921	NADH dehydrogenase subunit B; Validated; Region: PRK06411
700508004922	NADH dehydrogenase subunit A; Validated; Region: PRK07928
700508004923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
700508004924	phosphorylation site [posttranslational modification]
700508004925	intermolecular recognition site; other site
700508004926	YceI-like domain; Region: YceI; pfam04264
700508004927	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508004928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508004929	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700508004930	S-adenosylmethionine binding site [chemical binding]; other site
700508004931	Phosphotransferase enzyme family; Region: APH; pfam01636
700508004932	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
700508004933	putative active site [active]
700508004934	putative substrate binding site [chemical binding]; other site
700508004935	ATP binding site [chemical binding]; other site
700508004936	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508004937	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
700508004938	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
700508004939	active site
700508004940	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508004941	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004942	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
700508004943	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
700508004944	active site
700508004945	catalytic residues [active]
700508004946	metal binding site [ion binding]; metal-binding site
700508004947	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508004948	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508004949	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508004950	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
700508004951	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
700508004952	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508004953	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508004954	active site
700508004955	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508004956	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508004957	Predicted esterase [General function prediction only]; Region: COG0627
700508004958	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
700508004959	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508004960	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508004961	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508004962	active site
700508004963	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508004964	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508004965	active site
700508004966	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
700508004967	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
700508004968	active site
700508004969	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
700508004970	ferredoxin-NADP+ reductase; Region: PLN02852
700508004971	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508004972	peptide chain release factor 2; Validated; Region: prfB; PRK00578
700508004973	This domain is found in peptide chain release factors; Region: PCRF; smart00937
700508004974	RF-1 domain; Region: RF-1; pfam00472
700508004975	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
700508004976	Mechanosensitive ion channel; Region: MS_channel; pfam00924
700508004977	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
700508004978	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508004979	Walker A/P-loop; other site
700508004980	ATP binding site [chemical binding]; other site
700508004981	Q-loop/lid; other site
700508004982	ABC transporter signature motif; other site
700508004983	Walker B; other site
700508004984	D-loop; other site
700508004985	H-loop/switch region; other site
700508004986	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
700508004987	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
700508004988	FtsX-like permease family; Region: FtsX; pfam02687
700508004989	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
700508004990	SmpB-tmRNA interface; other site
700508004991	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508004992	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508004993	metal binding site [ion binding]; metal-binding site
700508004994	active site
700508004995	I-site; other site
700508004996	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
700508004997	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508004998	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
700508004999	nucleotide binding site [chemical binding]; other site
700508005000	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508005001	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508005002	NAD(P) binding site [chemical binding]; other site
700508005003	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508005004	active site
700508005005	short chain dehydrogenase; Provisional; Region: PRK06500
700508005006	classical (c) SDRs; Region: SDR_c; cd05233
700508005007	NAD(P) binding site [chemical binding]; other site
700508005008	active site
700508005009	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700508005010	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700508005011	MarR family; Region: MarR_2; pfam12802
700508005012	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
700508005013	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
700508005014	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700508005015	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
700508005016	FMN-binding pocket [chemical binding]; other site
700508005017	flavin binding motif; other site
700508005018	phosphate binding motif [ion binding]; other site
700508005019	beta-alpha-beta structure motif; other site
700508005020	NAD binding pocket [chemical binding]; other site
700508005021	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508005022	catalytic loop [active]
700508005023	iron binding site [ion binding]; other site
700508005024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508005026	Fatty acid desaturase; Region: FA_desaturase; pfam00487
700508005027	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
700508005028	putative di-iron ligands [ion binding]; other site
700508005029	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
700508005030	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
700508005031	cofactor binding site; other site
700508005032	DNA binding site [nucleotide binding]
700508005033	substrate interaction site [chemical binding]; other site
700508005034	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
700508005035	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700508005036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508005037	nucleotide binding region [chemical binding]; other site
700508005038	ATP-binding site [chemical binding]; other site
700508005039	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
700508005040	Part of AAA domain; Region: AAA_19; pfam13245
700508005041	Family description; Region: UvrD_C_2; pfam13538
700508005042	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700508005043	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508005044	ATP-binding site [chemical binding]; other site
700508005045	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
700508005046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508005047	ATP binding site [chemical binding]; other site
700508005048	putative Mg++ binding site [ion binding]; other site
700508005049	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
700508005050	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508005051	nucleotide binding region [chemical binding]; other site
700508005052	ATP-binding site [chemical binding]; other site
700508005053	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
700508005054	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508005055	ATP binding site [chemical binding]; other site
700508005056	putative Mg++ binding site [ion binding]; other site
700508005057	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508005058	ATP-binding site [chemical binding]; other site
700508005059	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
700508005060	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
700508005061	Part of AAA domain; Region: AAA_19; pfam13245
700508005062	Family description; Region: UvrD_C_2; pfam13538
700508005063	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
700508005064	FOG: CBS domain [General function prediction only]; Region: COG0517
700508005065	AAA ATPase domain; Region: AAA_16; pfam13191
700508005066	Domain of unknown function DUF87; Region: DUF87; pfam01935
700508005067	AAA-like domain; Region: AAA_10; pfam12846
700508005068	Zonular occludens toxin (Zot); Region: Zot; cl17485
700508005069	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
700508005070	ADP-ribose binding site [chemical binding]; other site
700508005071	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
700508005072	Mechanosensitive ion channel; Region: MS_channel; pfam00924
700508005073	Fic/DOC family; Region: Fic; cl00960
700508005074	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
700508005075	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
700508005076	G1 box; other site
700508005077	putative GEF interaction site [polypeptide binding]; other site
700508005078	GTP/Mg2+ binding site [chemical binding]; other site
700508005079	Switch I region; other site
700508005080	G2 box; other site
700508005081	G3 box; other site
700508005082	Switch II region; other site
700508005083	G4 box; other site
700508005084	G5 box; other site
700508005085	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
700508005086	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
700508005087	YceI-like domain; Region: YceI; pfam04264
700508005088	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700508005089	Sulfatase; Region: Sulfatase; cl17466
700508005090	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
700508005091	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
700508005092	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508005093	active site
700508005094	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508005095	chorismate mutase; Provisional; Region: PRK09269
700508005096	Chorismate mutase type II; Region: CM_2; cl00693
700508005097	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
700508005098	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
700508005099	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
700508005100	active site turn [active]
700508005101	phosphorylation site [posttranslational modification]
700508005102	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
700508005103	HPr interaction site; other site
700508005104	glycerol kinase (GK) interaction site [polypeptide binding]; other site
700508005105	active site
700508005106	phosphorylation site [posttranslational modification]
700508005107	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
700508005108	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
700508005109	active site
700508005110	trimer interface [polypeptide binding]; other site
700508005111	allosteric site; other site
700508005112	active site lid [active]
700508005113	hexamer (dimer of trimers) interface [polypeptide binding]; other site
700508005114	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
700508005115	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
700508005116	active site
700508005117	dimer interface [polypeptide binding]; other site
700508005118	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
700508005119	Patatin-like phospholipase; Region: Patatin; pfam01734
700508005120	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
700508005121	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
700508005122	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508005123	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
700508005124	active site
700508005125	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
700508005126	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508005127	acyl-activating enzyme (AAE) consensus motif; other site
700508005128	AMP binding site [chemical binding]; other site
700508005129	active site
700508005130	CoA binding site [chemical binding]; other site
700508005131	acyl carrier protein; Validated; Region: PRK05883
700508005132	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
700508005133	CrcB-like protein; Region: CRCB; pfam02537
700508005134	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
700508005135	DNA binding site [nucleotide binding]
700508005136	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
700508005137	AAA ATPase domain; Region: AAA_16; pfam13191
700508005138	Hemerythrin-like domain; Region: Hr-like; cd12108
700508005139	Fe binding site [ion binding]; other site
700508005140	phosphoglucomutase; Validated; Region: PRK07564
700508005141	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
700508005142	active site
700508005143	substrate binding site [chemical binding]; other site
700508005144	metal binding site [ion binding]; metal-binding site
700508005145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508005146	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508005147	putative substrate translocation pore; other site
700508005148	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700508005149	Coenzyme A binding pocket [chemical binding]; other site
700508005150	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005151	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508005152	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508005153	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508005154	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508005155	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
700508005156	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005157	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
700508005158	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
700508005159	tetramerization interface [polypeptide binding]; other site
700508005160	active site
700508005161	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
700508005162	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508005163	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508005164	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700508005165	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700508005166	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508005167	Walker A/P-loop; other site
700508005168	ATP binding site [chemical binding]; other site
700508005169	Q-loop/lid; other site
700508005170	ABC transporter signature motif; other site
700508005171	Walker B; other site
700508005172	D-loop; other site
700508005173	H-loop/switch region; other site
700508005174	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
700508005175	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700508005176	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508005177	Walker A/P-loop; other site
700508005178	ATP binding site [chemical binding]; other site
700508005179	Q-loop/lid; other site
700508005180	ABC transporter signature motif; other site
700508005181	Walker B; other site
700508005182	D-loop; other site
700508005183	H-loop/switch region; other site
700508005184	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
700508005185	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
700508005186	putative AMP binding site [chemical binding]; other site
700508005187	putative active site [active]
700508005188	acyl-activating enzyme (AAE) consensus motif; other site
700508005189	putative CoA binding site [chemical binding]; other site
700508005190	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
700508005191	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
700508005192	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
700508005193	active site
700508005194	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
700508005195	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508005196	active site
700508005197	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
700508005198	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700508005199	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508005200	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508005201	metal binding site [ion binding]; metal-binding site
700508005202	active site
700508005203	I-site; other site
700508005204	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
700508005205	hypothetical protein; Provisional; Region: PRK07877
700508005206	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
700508005207	ATP binding site [chemical binding]; other site
700508005208	substrate interface [chemical binding]; other site
700508005209	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
700508005210	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
700508005211	putative active site [active]
700508005212	putative catalytic site [active]
700508005213	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508005214	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508005215	active site
700508005216	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508005217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508005218	NAD(P) binding site [chemical binding]; other site
700508005219	active site
700508005220	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
700508005221	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508005222	dimer interface [polypeptide binding]; other site
700508005223	active site
700508005224	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508005225	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508005226	active site
700508005227	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508005228	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508005229	DNA-binding site [nucleotide binding]; DNA binding site
700508005230	FCD domain; Region: FCD; pfam07729
700508005231	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
700508005232	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508005233	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508005234	Protein of unknown function (DUF466); Region: DUF466; pfam04328
700508005235	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
700508005236	Carbon starvation protein CstA; Region: CstA; pfam02554
700508005237	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
700508005238	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
700508005239	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
700508005240	active site
700508005241	DNA binding site [nucleotide binding]
700508005242	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
700508005243	DNA binding site [nucleotide binding]
700508005244	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
700508005245	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508005246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508005247	active site
700508005248	phosphorylation site [posttranslational modification]
700508005249	intermolecular recognition site; other site
700508005250	dimerization interface [polypeptide binding]; other site
700508005251	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508005252	DNA binding residues [nucleotide binding]
700508005253	dimerization interface [polypeptide binding]; other site
700508005254	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
700508005255	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
700508005256	Moco binding site; other site
700508005257	metal coordination site [ion binding]; other site
700508005258	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700508005259	Cytochrome P450; Region: p450; cl12078
700508005260	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508005261	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005262	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508005263	short chain dehydrogenase; Provisional; Region: PRK07832
700508005264	classical (c) SDRs; Region: SDR_c; cd05233
700508005265	NAD(P) binding site [chemical binding]; other site
700508005266	active site
700508005267	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
700508005268	dimer interface [polypeptide binding]; other site
700508005269	active site
700508005270	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
700508005271	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
700508005272	active site
700508005273	FMN binding site [chemical binding]; other site
700508005274	substrate binding site [chemical binding]; other site
700508005275	3Fe-4S cluster binding site [ion binding]; other site
700508005276	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
700508005277	domain_subunit interface; other site
700508005278	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
700508005279	Flavodoxin; Region: Flavodoxin_1; pfam00258
700508005280	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
700508005281	FAD binding pocket [chemical binding]; other site
700508005282	FAD binding motif [chemical binding]; other site
700508005283	catalytic residues [active]
700508005284	NAD binding pocket [chemical binding]; other site
700508005285	phosphate binding motif [ion binding]; other site
700508005286	beta-alpha-beta structure motif; other site
700508005287	Predicted ATPase [General function prediction only]; Region: COG4637
700508005288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508005289	Walker A/P-loop; other site
700508005290	ATP binding site [chemical binding]; other site
700508005291	DNA polymerase IV; Validated; Region: PRK03352
700508005292	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
700508005293	active site
700508005294	DNA binding site [nucleotide binding]
700508005295	Predicted flavoprotein [General function prediction only]; Region: COG0431
700508005296	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700508005297	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
700508005298	catalytic residues [active]
700508005299	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
700508005300	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
700508005301	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
700508005302	Class I ribonucleotide reductase; Region: RNR_I; cd01679
700508005303	active site
700508005304	dimer interface [polypeptide binding]; other site
700508005305	catalytic residues [active]
700508005306	effector binding site; other site
700508005307	R2 peptide binding site; other site
700508005308	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
700508005309	sequence-specific DNA binding site [nucleotide binding]; other site
700508005310	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508005311	salt bridge; other site
700508005312	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508005313	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005314	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005315	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508005316	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
700508005317	ABC1 family; Region: ABC1; cl17513
700508005318	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508005319	active site
700508005320	ATP binding site [chemical binding]; other site
700508005321	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
700508005322	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
700508005323	dimerization interface [polypeptide binding]; other site
700508005324	substrate binding pocket [chemical binding]; other site
700508005325	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508005326	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
700508005327	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
700508005328	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005329	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508005330	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
700508005331	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
700508005332	dimer interface [polypeptide binding]; other site
700508005333	putative radical transfer pathway; other site
700508005334	diiron center [ion binding]; other site
700508005335	tyrosyl radical; other site
700508005336	Histidine kinase; Region: HisKA_3; pfam07730
700508005337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508005338	Response regulator receiver domain; Region: Response_reg; pfam00072
700508005339	active site
700508005340	phosphorylation site [posttranslational modification]
700508005341	intermolecular recognition site; other site
700508005342	dimerization interface [polypeptide binding]; other site
700508005343	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508005344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508005345	active site
700508005346	phosphorylation site [posttranslational modification]
700508005347	intermolecular recognition site; other site
700508005348	dimerization interface [polypeptide binding]; other site
700508005349	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508005350	DNA binding residues [nucleotide binding]
700508005351	dimerization interface [polypeptide binding]; other site
700508005352	Cupin; Region: Cupin_1; smart00835
700508005353	Cupin; Region: Cupin_1; smart00835
700508005354	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
700508005355	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700508005356	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700508005357	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
700508005358	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508005359	catalytic loop [active]
700508005360	iron binding site [ion binding]; other site
700508005361	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700508005362	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
700508005363	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
700508005364	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
700508005365	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
700508005366	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
700508005367	putative NAD(P) binding site [chemical binding]; other site
700508005368	putative substrate binding site [chemical binding]; other site
700508005369	catalytic Zn binding site [ion binding]; other site
700508005370	structural Zn binding site [ion binding]; other site
700508005371	dimer interface [polypeptide binding]; other site
700508005372	YCII-related domain; Region: YCII; cl00999
700508005373	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
700508005374	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
700508005375	intersubunit interface [polypeptide binding]; other site
700508005376	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
700508005377	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
700508005378	D-pathway; other site
700508005379	Putative ubiquinol binding site [chemical binding]; other site
700508005380	Low-spin heme (heme b) binding site [chemical binding]; other site
700508005381	Putative water exit pathway; other site
700508005382	Binuclear center (heme o3/CuB) [ion binding]; other site
700508005383	K-pathway; other site
700508005384	Putative proton exit pathway; other site
700508005385	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
700508005386	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
700508005387	phosphoserine phosphatase SerB; Region: serB; TIGR00338
700508005388	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508005389	motif II; other site
700508005390	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
700508005391	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508005392	DNA-binding site [nucleotide binding]; DNA binding site
700508005393	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508005394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508005395	homodimer interface [polypeptide binding]; other site
700508005396	catalytic residue [active]
700508005397	Predicted membrane protein [Function unknown]; Region: COG2364
700508005398	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
700508005399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508005400	Walker A/P-loop; other site
700508005401	ATP binding site [chemical binding]; other site
700508005402	ABC transporter; Region: ABC_tran; pfam00005
700508005403	Q-loop/lid; other site
700508005404	ABC transporter signature motif; other site
700508005405	Walker B; other site
700508005406	D-loop; other site
700508005407	enoyl-CoA hydratase; Provisional; Region: PRK05980
700508005408	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508005409	substrate binding site [chemical binding]; other site
700508005410	oxyanion hole (OAH) forming residues; other site
700508005411	trimer interface [polypeptide binding]; other site
700508005412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508005413	S-adenosylmethionine binding site [chemical binding]; other site
700508005414	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
700508005415	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
700508005416	FOG: WD40-like repeat [Function unknown]; Region: COG1520
700508005417	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
700508005418	active site
700508005419	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
700508005420	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
700508005421	trimer interface [polypeptide binding]; other site
700508005422	active site
700508005423	substrate binding site [chemical binding]; other site
700508005424	CoA binding site [chemical binding]; other site
700508005425	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
700508005426	putative hydrophobic ligand binding site [chemical binding]; other site
700508005427	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508005428	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700508005429	Uncharacterized conserved protein [Function unknown]; Region: COG1543
700508005430	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
700508005431	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
700508005432	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700508005433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508005434	S-adenosylmethionine binding site [chemical binding]; other site
700508005435	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
700508005436	Ligand binding site [chemical binding]; other site
700508005437	Electron transfer flavoprotein domain; Region: ETF; pfam01012
700508005438	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
700508005439	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
700508005440	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
700508005441	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
700508005442	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700508005443	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
700508005444	putative acyl-acceptor binding pocket; other site
700508005445	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
700508005446	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
700508005447	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508005448	catalytic residue [active]
700508005449	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
700508005450	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
700508005451	Ligand Binding Site [chemical binding]; other site
700508005452	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
700508005453	4-coumarate--CoA ligase; Region: PLN02246
700508005454	4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904
700508005455	acyl-activating enzyme (AAE) consensus motif; other site
700508005456	active site
700508005457	putative CoA binding site [chemical binding]; other site
700508005458	AMP binding site [chemical binding]; other site
700508005459	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508005460	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700508005461	Protein of unknown function (DUF419); Region: DUF419; pfam04237
700508005462	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
700508005463	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
700508005464	nucleotide binding pocket [chemical binding]; other site
700508005465	K-X-D-G motif; other site
700508005466	catalytic site [active]
700508005467	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
700508005468	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
700508005469	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
700508005470	Dimer interface [polypeptide binding]; other site
700508005471	BRCT sequence motif; other site
700508005472	spermidine synthase; Provisional; Region: PRK03612
700508005473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508005474	S-adenosylmethionine binding site [chemical binding]; other site
700508005475	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
700508005476	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
700508005477	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
700508005478	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
700508005479	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
700508005480	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
700508005481	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
700508005482	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
700508005483	pyruvate dehydrogenase; Provisional; Region: PRK09124
700508005484	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
700508005485	PYR/PP interface [polypeptide binding]; other site
700508005486	tetramer interface [polypeptide binding]; other site
700508005487	dimer interface [polypeptide binding]; other site
700508005488	TPP binding site [chemical binding]; other site
700508005489	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
700508005490	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
700508005491	TPP-binding site [chemical binding]; other site
700508005492	6-phosphofructokinase; Provisional; Region: PRK03202
700508005493	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
700508005494	active site
700508005495	ADP/pyrophosphate binding site [chemical binding]; other site
700508005496	dimerization interface [polypeptide binding]; other site
700508005497	allosteric effector site; other site
700508005498	fructose-1,6-bisphosphate binding site; other site
700508005499	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
700508005500	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
700508005501	GatB domain; Region: GatB_Yqey; smart00845
700508005502	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
700508005503	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
700508005504	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
700508005505	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
700508005506	PYR/PP interface [polypeptide binding]; other site
700508005507	dimer interface [polypeptide binding]; other site
700508005508	TPP binding site [chemical binding]; other site
700508005509	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
700508005510	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
700508005511	TPP-binding site [chemical binding]; other site
700508005512	dimer interface [polypeptide binding]; other site
700508005513	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
700508005514	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
700508005515	putative valine binding site [chemical binding]; other site
700508005516	dimer interface [polypeptide binding]; other site
700508005517	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
700508005518	ketol-acid reductoisomerase; Provisional; Region: PRK05479
700508005519	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
700508005520	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
700508005521	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
700508005522	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
700508005523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508005524	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
700508005525	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
700508005526	ligand binding site [chemical binding]; other site
700508005527	NAD binding site [chemical binding]; other site
700508005528	dimerization interface [polypeptide binding]; other site
700508005529	catalytic site [active]
700508005530	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
700508005531	putative L-serine binding site [chemical binding]; other site
700508005532	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
700508005533	tartrate dehydrogenase; Provisional; Region: PRK08194
700508005534	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
700508005535	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
700508005536	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
700508005537	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
700508005538	dimer interface [polypeptide binding]; other site
700508005539	decamer (pentamer of dimers) interface [polypeptide binding]; other site
700508005540	catalytic triad [active]
700508005541	peroxidatic and resolving cysteines [active]
700508005542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508005543	putative substrate translocation pore; other site
700508005544	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
700508005545	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
700508005546	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
700508005547	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
700508005548	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
700508005549	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
700508005550	active site
700508005551	HIGH motif; other site
700508005552	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
700508005553	active site
700508005554	KMSKS motif; other site
700508005555	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
700508005556	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
700508005557	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
700508005558	Transcriptional regulator [Transcription]; Region: IclR; COG1414
700508005559	Bacterial transcriptional regulator; Region: IclR; pfam01614
700508005560	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
700508005561	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
700508005562	substrate binding site [chemical binding]; other site
700508005563	ligand binding site [chemical binding]; other site
700508005564	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
700508005565	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
700508005566	substrate binding site [chemical binding]; other site
700508005567	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
700508005568	IHF - DNA interface [nucleotide binding]; other site
700508005569	IHF dimer interface [polypeptide binding]; other site
700508005570	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
700508005571	active site
700508005572	Ap6A binding site [chemical binding]; other site
700508005573	nudix motif; other site
700508005574	metal binding site [ion binding]; metal-binding site
700508005575	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508005576	catalytic core [active]
700508005577	polyphosphate kinase; Provisional; Region: PRK05443
700508005578	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
700508005579	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
700508005580	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
700508005581	putative domain interface [polypeptide binding]; other site
700508005582	putative active site [active]
700508005583	catalytic site [active]
700508005584	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
700508005585	putative domain interface [polypeptide binding]; other site
700508005586	putative active site [active]
700508005587	catalytic site [active]
700508005588	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
700508005589	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
700508005590	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
700508005591	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
700508005592	cystathionine gamma-lyase; Validated; Region: PRK07582
700508005593	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508005594	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508005595	catalytic residue [active]
700508005596	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
700508005597	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
700508005598	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
700508005599	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
700508005600	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700508005601	AsnC family; Region: AsnC_trans_reg; pfam01037
700508005602	thiamine monophosphate kinase; Provisional; Region: PRK05731
700508005603	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
700508005604	ATP binding site [chemical binding]; other site
700508005605	dimerization interface [polypeptide binding]; other site
700508005606	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
700508005607	ligand binding site [chemical binding]; other site
700508005608	active site
700508005609	UGI interface [polypeptide binding]; other site
700508005610	catalytic site [active]
700508005611	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
700508005612	DAK2 domain; Region: Dak2; pfam02734
700508005613	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
700508005614	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
700508005615	generic binding surface II; other site
700508005616	ssDNA binding site; other site
700508005617	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508005618	ATP binding site [chemical binding]; other site
700508005619	putative Mg++ binding site [ion binding]; other site
700508005620	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508005621	nucleotide binding region [chemical binding]; other site
700508005622	ATP-binding site [chemical binding]; other site
700508005623	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
700508005624	Predicted membrane protein [Function unknown]; Region: COG2119
700508005625	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
700508005626	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
700508005627	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700508005628	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508005629	anti sigma factor interaction site; other site
700508005630	regulatory phosphorylation site [posttranslational modification]; other site
700508005631	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700508005632	active site
700508005633	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
700508005634	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508005635	GAF domain; Region: GAF; pfam01590
700508005636	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
700508005637	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
700508005638	Penicillinase repressor; Region: Pencillinase_R; pfam03965
700508005639	Peptidase family M48; Region: Peptidase_M48; cl12018
700508005640	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
700508005641	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
700508005642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
700508005643	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700508005644	Thioredoxin; Region: Thioredoxin_4; pfam13462
700508005645	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
700508005646	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
700508005647	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508005648	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508005649	active site
700508005650	ATP binding site [chemical binding]; other site
700508005651	substrate binding site [chemical binding]; other site
700508005652	activation loop (A-loop); other site
700508005653	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005654	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508005655	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
700508005656	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700508005657	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700508005658	active site
700508005659	catalytic tetrad [active]
700508005660	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700508005661	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700508005662	active site
700508005663	catalytic tetrad [active]
700508005664	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508005665	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508005666	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
700508005667	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
700508005668	catalytic residues [active]
700508005669	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
700508005670	putative active site [active]
700508005671	redox center [active]
700508005672	pyruvate carboxylase; Reviewed; Region: PRK12999
700508005673	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700508005674	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508005675	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
700508005676	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
700508005677	active site
700508005678	catalytic residues [active]
700508005679	metal binding site [ion binding]; metal-binding site
700508005680	homodimer binding site [polypeptide binding]; other site
700508005681	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700508005682	carboxyltransferase (CT) interaction site; other site
700508005683	biotinylation site [posttranslational modification]; other site
700508005684	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
700508005685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508005686	S-adenosylmethionine binding site [chemical binding]; other site
700508005687	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
700508005688	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
700508005689	active site
700508005690	(T/H)XGH motif; other site
700508005691	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
700508005692	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
700508005693	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
700508005694	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508005695	active site
700508005696	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
700508005697	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
700508005698	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
700508005699	active site
700508005700	dimer interface [polypeptide binding]; other site
700508005701	non-prolyl cis peptide bond; other site
700508005702	insertion regions; other site
700508005703	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
700508005704	ribonuclease III; Reviewed; Region: rnc; PRK00102
700508005705	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
700508005706	dimerization interface [polypeptide binding]; other site
700508005707	active site
700508005708	metal binding site [ion binding]; metal-binding site
700508005709	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
700508005710	dsRNA binding site [nucleotide binding]; other site
700508005711	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
700508005712	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
700508005713	DNA binding site [nucleotide binding]
700508005714	catalytic residue [active]
700508005715	H2TH interface [polypeptide binding]; other site
700508005716	putative catalytic residues [active]
700508005717	turnover-facilitating residue; other site
700508005718	intercalation triad [nucleotide binding]; other site
700508005719	8OG recognition residue [nucleotide binding]; other site
700508005720	putative reading head residues; other site
700508005721	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
700508005722	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
700508005723	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
700508005724	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
700508005725	acylphosphatase; Provisional; Region: PRK14422
700508005726	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
700508005727	AAA domain; Region: AAA_23; pfam13476
700508005728	Walker A/P-loop; other site
700508005729	ATP binding site [chemical binding]; other site
700508005730	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
700508005731	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
700508005732	ABC transporter signature motif; other site
700508005733	Walker B; other site
700508005734	D-loop; other site
700508005735	H-loop/switch region; other site
700508005736	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
700508005737	Subunit I/III interface [polypeptide binding]; other site
700508005738	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
700508005739	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
700508005740	homotetramer interface [polypeptide binding]; other site
700508005741	FMN binding site [chemical binding]; other site
700508005742	homodimer contacts [polypeptide binding]; other site
700508005743	putative active site [active]
700508005744	putative substrate binding site [chemical binding]; other site
700508005745	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
700508005746	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
700508005747	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700508005748	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
700508005749	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
700508005750	Nitrogen regulatory protein P-II; Region: P-II; smart00938
700508005751	PII uridylyl-transferase; Provisional; Region: PRK03381
700508005752	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
700508005753	metal binding triad; other site
700508005754	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
700508005755	HD domain; Region: HD; pfam01966
700508005756	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
700508005757	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
700508005758	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
700508005759	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
700508005760	putative [Fe4-S4] binding site [ion binding]; other site
700508005761	putative molybdopterin cofactor binding site [chemical binding]; other site
700508005762	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
700508005763	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
700508005764	putative molybdopterin cofactor binding site; other site
700508005765	signal recognition particle protein; Provisional; Region: PRK10867
700508005766	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
700508005767	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
700508005768	P loop; other site
700508005769	GTP binding site [chemical binding]; other site
700508005770	Signal peptide binding domain; Region: SRP_SPB; pfam02978
700508005771	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
700508005772	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508005773	active site
700508005774	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
700508005775	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
700508005776	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
700508005777	FAD binding pocket [chemical binding]; other site
700508005778	FAD binding motif [chemical binding]; other site
700508005779	catalytic residues [active]
700508005780	NAD binding pocket [chemical binding]; other site
700508005781	phosphate binding motif [ion binding]; other site
700508005782	beta-alpha-beta structure motif; other site
700508005783	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
700508005784	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
700508005785	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
700508005786	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
700508005787	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
700508005788	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
700508005789	active site
700508005790	dimer interface [polypeptide binding]; other site
700508005791	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
700508005792	Ligand Binding Site [chemical binding]; other site
700508005793	Molecular Tunnel; other site
700508005794	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
700508005795	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700508005796	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508005797	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
700508005798	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
700508005799	putative oligomer interface [polypeptide binding]; other site
700508005800	putative active site [active]
700508005801	metal binding site [ion binding]; metal-binding site
700508005802	SnoaL-like domain; Region: SnoaL_4; pfam13577
700508005803	SnoaL-like domain; Region: SnoaL_3; pfam13474
700508005804	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
700508005805	hypothetical protein; Provisional; Region: PRK02821
700508005806	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
700508005807	G-X-X-G motif; other site
700508005808	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
700508005809	RimM N-terminal domain; Region: RimM; pfam01782
700508005810	PRC-barrel domain; Region: PRC; pfam05239
700508005811	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
700508005812	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
700508005813	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
700508005814	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
700508005815	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
700508005816	Catalytic site [active]
700508005817	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
700508005818	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
700508005819	RNA/DNA hybrid binding site [nucleotide binding]; other site
700508005820	active site
700508005821	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
700508005822	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
700508005823	Dienelactone hydrolase family; Region: DLH; pfam01738
700508005824	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
700508005825	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508005826	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
700508005827	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
700508005828	Walker A/P-loop; other site
700508005829	ATP binding site [chemical binding]; other site
700508005830	Q-loop/lid; other site
700508005831	ABC transporter signature motif; other site
700508005832	Walker B; other site
700508005833	D-loop; other site
700508005834	H-loop/switch region; other site
700508005835	TOBE domain; Region: TOBE_2; pfam08402
700508005836	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
700508005837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508005838	dimer interface [polypeptide binding]; other site
700508005839	conserved gate region; other site
700508005840	ABC-ATPase subunit interface; other site
700508005841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508005842	dimer interface [polypeptide binding]; other site
700508005843	conserved gate region; other site
700508005844	ABC-ATPase subunit interface; other site
700508005845	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
700508005846	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
700508005847	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
700508005848	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
700508005849	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
700508005850	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
700508005851	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
700508005852	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
700508005853	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508005854	GAF domain; Region: GAF; pfam01590
700508005855	hypothetical protein; Reviewed; Region: PRK12497
700508005856	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
700508005857	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
700508005858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508005859	Walker A motif; other site
700508005860	ATP binding site [chemical binding]; other site
700508005861	Walker B motif; other site
700508005862	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
700508005863	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
700508005864	DNA protecting protein DprA; Region: dprA; TIGR00732
700508005865	CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655
700508005866	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
700508005867	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
700508005868	FAD binding pocket [chemical binding]; other site
700508005869	FAD binding motif [chemical binding]; other site
700508005870	phosphate binding motif [ion binding]; other site
700508005871	NAD binding pocket [chemical binding]; other site
700508005872	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
700508005873	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
700508005874	putative active site [active]
700508005875	putative substrate binding site [chemical binding]; other site
700508005876	putative FMN binding site [chemical binding]; other site
700508005877	putative catalytic residues [active]
700508005878	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
700508005879	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700508005880	active site
700508005881	DNA binding site [nucleotide binding]
700508005882	Int/Topo IB signature motif; other site
700508005883	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
700508005884	Peptidase family M23; Region: Peptidase_M23; pfam01551
700508005885	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
700508005886	rRNA interaction site [nucleotide binding]; other site
700508005887	S8 interaction site; other site
700508005888	putative laminin-1 binding site; other site
700508005889	elongation factor Ts; Provisional; Region: tsf; PRK09377
700508005890	UBA/TS-N domain; Region: UBA; pfam00627
700508005891	Elongation factor TS; Region: EF_TS; pfam00889
700508005892	Elongation factor TS; Region: EF_TS; pfam00889
700508005893	amidase; Provisional; Region: PRK07869
700508005894	Amidase; Region: Amidase; pfam01425
700508005895	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508005896	MarR family; Region: MarR; pfam01047
700508005897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508005898	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700508005899	S-adenosylmethionine binding site [chemical binding]; other site
700508005900	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
700508005901	putative nucleotide binding site [chemical binding]; other site
700508005902	uridine monophosphate binding site [chemical binding]; other site
700508005903	homohexameric interface [polypeptide binding]; other site
700508005904	ribosome recycling factor; Reviewed; Region: frr; PRK00083
700508005905	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
700508005906	hinge region; other site
700508005907	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
700508005908	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
700508005909	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
700508005910	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508005911	FeS/SAM binding site; other site
700508005912	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508005913	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508005914	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
700508005915	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
700508005916	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
700508005917	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
700508005918	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
700508005919	amino acid transporter; Region: 2A0306; TIGR00909
700508005920	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
700508005921	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
700508005922	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
700508005923	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
700508005924	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700508005925	catalytic residues [active]
700508005926	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
700508005927	Fasciclin domain; Region: Fasciclin; pfam02469
700508005928	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
700508005929	Fasciclin domain; Region: Fasciclin; pfam02469
700508005930	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
700508005931	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
700508005932	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
700508005933	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
700508005934	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
700508005935	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
700508005936	active site
700508005937	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
700508005938	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
700508005939	putative substrate binding region [chemical binding]; other site
700508005940	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
700508005941	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
700508005942	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
700508005943	Predicted acetyltransferase [General function prediction only]; Region: COG3393
700508005944	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
700508005945	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
700508005946	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
700508005947	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700508005948	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
700508005949	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
700508005950	active site
700508005951	cobyric acid synthase; Provisional; Region: PRK00784
700508005952	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
700508005953	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
700508005954	catalytic triad [active]
700508005955	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508005956	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
700508005957	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700508005958	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
700508005959	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
700508005960	catalytic triad [active]
700508005961	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508005962	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
700508005963	NAD(P) binding site [chemical binding]; other site
700508005964	catalytic residues [active]
700508005965	short chain dehydrogenase; Provisional; Region: PRK06057
700508005966	classical (c) SDRs; Region: SDR_c; cd05233
700508005967	NAD(P) binding site [chemical binding]; other site
700508005968	active site
700508005969	Transcriptional regulators [Transcription]; Region: FadR; COG2186
700508005970	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508005971	DNA-binding site [nucleotide binding]; DNA binding site
700508005972	FCD domain; Region: FCD; pfam07729
700508005973	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508005974	dimerization interface [polypeptide binding]; other site
700508005975	putative DNA binding site [nucleotide binding]; other site
700508005976	putative Zn2+ binding site [ion binding]; other site
700508005977	High-affinity nickel-transport protein; Region: NicO; cl00964
700508005978	mycothione reductase; Reviewed; Region: PRK07846
700508005979	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508005980	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508005981	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
700508005982	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
700508005983	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508005984	malate:quinone oxidoreductase; Validated; Region: PRK05257
700508005985	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
700508005986	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
700508005987	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
700508005988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
700508005989	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
700508005990	metal ion-dependent adhesion site (MIDAS); other site
700508005991	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
700508005992	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
700508005993	Walker A motif; other site
700508005994	homodimer interface [polypeptide binding]; other site
700508005995	ATP binding site [chemical binding]; other site
700508005996	hydroxycobalamin binding site [chemical binding]; other site
700508005997	Walker B motif; other site
700508005998	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
700508005999	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
700508006000	catalytic triad [active]
700508006001	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
700508006002	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
700508006003	active site
700508006004	SAM binding site [chemical binding]; other site
700508006005	homodimer interface [polypeptide binding]; other site
700508006006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508006007	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508006008	putative substrate translocation pore; other site
700508006009	prolyl-tRNA synthetase; Provisional; Region: PRK09194
700508006010	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
700508006011	dimer interface [polypeptide binding]; other site
700508006012	motif 1; other site
700508006013	active site
700508006014	motif 2; other site
700508006015	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
700508006016	putative deacylase active site [active]
700508006017	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700508006018	active site
700508006019	motif 3; other site
700508006020	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
700508006021	anticodon binding site; other site
700508006022	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
700508006023	dinuclear metal binding motif [ion binding]; other site
700508006024	ribosome maturation protein RimP; Reviewed; Region: PRK00092
700508006025	Sm and related proteins; Region: Sm_like; cl00259
700508006026	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
700508006027	putative oligomer interface [polypeptide binding]; other site
700508006028	putative RNA binding site [nucleotide binding]; other site
700508006029	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
700508006030	NusA N-terminal domain; Region: NusA_N; pfam08529
700508006031	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
700508006032	RNA binding site [nucleotide binding]; other site
700508006033	homodimer interface [polypeptide binding]; other site
700508006034	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
700508006035	G-X-X-G motif; other site
700508006036	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
700508006037	G-X-X-G motif; other site
700508006038	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
700508006039	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
700508006040	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
700508006041	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
700508006042	G1 box; other site
700508006043	putative GEF interaction site [polypeptide binding]; other site
700508006044	GTP/Mg2+ binding site [chemical binding]; other site
700508006045	Switch I region; other site
700508006046	G2 box; other site
700508006047	G3 box; other site
700508006048	Switch II region; other site
700508006049	G4 box; other site
700508006050	G5 box; other site
700508006051	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
700508006052	Translation-initiation factor 2; Region: IF-2; pfam11987
700508006053	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
700508006054	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
700508006055	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
700508006056	DHH family; Region: DHH; pfam01368
700508006057	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
700508006058	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
700508006059	Predicted esterase [General function prediction only]; Region: COG0627
700508006060	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
700508006061	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
700508006062	Walker A/P-loop; other site
700508006063	ATP binding site [chemical binding]; other site
700508006064	Q-loop/lid; other site
700508006065	ABC transporter signature motif; other site
700508006066	Walker B; other site
700508006067	D-loop; other site
700508006068	H-loop/switch region; other site
700508006069	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
700508006070	NMT1/THI5 like; Region: NMT1; pfam09084
700508006071	substrate binding pocket [chemical binding]; other site
700508006072	membrane-bound complex binding site; other site
700508006073	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
700508006074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508006075	dimer interface [polypeptide binding]; other site
700508006076	conserved gate region; other site
700508006077	putative PBP binding loops; other site
700508006078	ABC-ATPase subunit interface; other site
700508006079	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700508006080	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700508006081	DNA binding site [nucleotide binding]
700508006082	domain linker motif; other site
700508006083	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700508006084	dimerization interface [polypeptide binding]; other site
700508006085	ligand binding site [chemical binding]; other site
700508006086	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700508006087	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700508006088	Protein of unknown function (DUF993); Region: DUF993; pfam06187
700508006089	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
700508006090	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
700508006091	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
700508006092	intersubunit interface [polypeptide binding]; other site
700508006093	active site
700508006094	catalytic residue [active]
700508006095	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700508006096	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700508006097	TM-ABC transporter signature motif; other site
700508006098	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
700508006099	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
700508006100	Walker A/P-loop; other site
700508006101	ATP binding site [chemical binding]; other site
700508006102	Q-loop/lid; other site
700508006103	ABC transporter signature motif; other site
700508006104	Walker B; other site
700508006105	D-loop; other site
700508006106	H-loop/switch region; other site
700508006107	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
700508006108	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
700508006109	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
700508006110	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
700508006111	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700508006112	nucleotide binding site [chemical binding]; other site
700508006113	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
700508006114	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
700508006115	putative NAD(P) binding site [chemical binding]; other site
700508006116	catalytic Zn binding site [ion binding]; other site
700508006117	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
700508006118	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
700508006119	enoyl-CoA hydratase; Provisional; Region: PRK06190
700508006120	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508006121	substrate binding site [chemical binding]; other site
700508006122	oxyanion hole (OAH) forming residues; other site
700508006123	trimer interface [polypeptide binding]; other site
700508006124	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
700508006125	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
700508006126	Predicted acyl esterases [General function prediction only]; Region: COG2936
700508006127	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
700508006128	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
700508006129	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
700508006130	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700508006131	active site
700508006132	metal binding site [ion binding]; metal-binding site
700508006133	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
700508006134	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
700508006135	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
700508006136	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
700508006137	RNA binding site [nucleotide binding]; other site
700508006138	active site
700508006139	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
700508006140	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700508006141	hydrophobic ligand binding site; other site
700508006142	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
700508006143	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508006144	putative DNA binding site [nucleotide binding]; other site
700508006145	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
700508006146	FeoA domain; Region: FeoA; pfam04023
700508006147	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
700508006148	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
700508006149	active site
700508006150	Riboflavin kinase; Region: Flavokinase; pfam01687
700508006151	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
700508006152	16S/18S rRNA binding site [nucleotide binding]; other site
700508006153	S13e-L30e interaction site [polypeptide binding]; other site
700508006154	25S rRNA binding site [nucleotide binding]; other site
700508006155	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
700508006156	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
700508006157	oligomer interface [polypeptide binding]; other site
700508006158	RNA binding site [nucleotide binding]; other site
700508006159	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
700508006160	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
700508006161	RNase E interface [polypeptide binding]; other site
700508006162	trimer interface [polypeptide binding]; other site
700508006163	active site
700508006164	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
700508006165	putative nucleic acid binding region [nucleotide binding]; other site
700508006166	G-X-X-G motif; other site
700508006167	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
700508006168	RNA binding site [nucleotide binding]; other site
700508006169	domain interface; other site
700508006170	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
700508006171	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
700508006172	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
700508006173	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
700508006174	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
700508006175	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
700508006176	hexamer interface [polypeptide binding]; other site
700508006177	ligand binding site [chemical binding]; other site
700508006178	putative active site [active]
700508006179	NAD(P) binding site [chemical binding]; other site
700508006180	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700508006181	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508006182	putative DNA binding site [nucleotide binding]; other site
700508006183	putative Zn2+ binding site [ion binding]; other site
700508006184	AsnC family; Region: AsnC_trans_reg; pfam01037
700508006185	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700508006186	extended (e) SDRs; Region: SDR_e; cd08946
700508006187	NAD(P) binding site [chemical binding]; other site
700508006188	substrate binding site [chemical binding]; other site
700508006189	active site
700508006190	META domain; Region: META; pfam03724
700508006191	META domain; Region: META; pfam03724
700508006192	dihydrodipicolinate reductase; Provisional; Region: PRK00048
700508006193	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
700508006194	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
700508006195	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
700508006196	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700508006197	Dienelactone hydrolase family; Region: DLH; pfam01738
700508006198	thymidylate synthase; Reviewed; Region: thyA; PRK01827
700508006199	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
700508006200	dimerization interface [polypeptide binding]; other site
700508006201	active site
700508006202	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
700508006203	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
700508006204	folate binding site [chemical binding]; other site
700508006205	NADP+ binding site [chemical binding]; other site
700508006206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
700508006207	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
700508006208	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508006209	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508006210	metal binding site [ion binding]; metal-binding site
700508006211	active site
700508006212	I-site; other site
700508006213	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
700508006214	classical (c) SDRs; Region: SDR_c; cd05233
700508006215	NAD(P) binding site [chemical binding]; other site
700508006216	active site
700508006217	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
700508006218	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
700508006219	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
700508006220	nucleoside/Zn binding site; other site
700508006221	dimer interface [polypeptide binding]; other site
700508006222	catalytic motif [active]
700508006223	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700508006224	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
700508006225	dimer interface [polypeptide binding]; other site
700508006226	active site
700508006227	catalytic residue [active]
700508006228	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
700508006229	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508006230	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
700508006231	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700508006232	Leucine carboxyl methyltransferase; Region: LCM; cl01306
700508006233	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
700508006234	classical (c) SDRs; Region: SDR_c; cd05233
700508006235	NAD(P) binding site [chemical binding]; other site
700508006236	active site
700508006237	Uncharacterized conserved protein [Function unknown]; Region: COG1359
700508006238	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
700508006239	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
700508006240	Sulfate transporter family; Region: Sulfate_transp; pfam00916
700508006241	Sulfate transporter family; Region: Sulfate_transp; pfam00916
700508006242	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
700508006243	active site clefts [active]
700508006244	zinc binding site [ion binding]; other site
700508006245	dimer interface [polypeptide binding]; other site
700508006246	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
700508006247	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
700508006248	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
700508006249	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508006250	Coenzyme A binding pocket [chemical binding]; other site
700508006251	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
700508006252	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508006253	non-specific DNA binding site [nucleotide binding]; other site
700508006254	salt bridge; other site
700508006255	sequence-specific DNA binding site [nucleotide binding]; other site
700508006256	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
700508006257	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700508006258	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
700508006259	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700508006260	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
700508006261	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508006262	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508006263	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508006264	recombinase A; Provisional; Region: recA; PRK09354
700508006265	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
700508006266	hexamer interface [polypeptide binding]; other site
700508006267	Walker A motif; other site
700508006268	ATP binding site [chemical binding]; other site
700508006269	Walker B motif; other site
700508006270	recombination regulator RecX; Reviewed; Region: recX; PRK00117
700508006271	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
700508006272	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
700508006273	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700508006274	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508006275	NAD(P) binding site [chemical binding]; other site
700508006276	active site
700508006277	MarR family; Region: MarR_2; pfam12802
700508006278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508006279	putative substrate translocation pore; other site
700508006280	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508006281	dimer interface [polypeptide binding]; other site
700508006282	conserved gate region; other site
700508006283	putative PBP binding loops; other site
700508006284	ABC-ATPase subunit interface; other site
700508006285	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700508006286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508006287	dimer interface [polypeptide binding]; other site
700508006288	conserved gate region; other site
700508006289	putative PBP binding loops; other site
700508006290	ABC-ATPase subunit interface; other site
700508006291	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
700508006292	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508006293	substrate binding pocket [chemical binding]; other site
700508006294	membrane-bound complex binding site; other site
700508006295	hinge residues; other site
700508006296	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700508006297	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700508006298	Walker A/P-loop; other site
700508006299	ATP binding site [chemical binding]; other site
700508006300	Q-loop/lid; other site
700508006301	ABC transporter signature motif; other site
700508006302	Walker B; other site
700508006303	D-loop; other site
700508006304	H-loop/switch region; other site
700508006305	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
700508006306	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
700508006307	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508006308	FeS/SAM binding site; other site
700508006309	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
700508006310	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
700508006311	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
700508006312	active site
700508006313	metal binding site [ion binding]; metal-binding site
700508006314	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
700508006315	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
700508006316	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
700508006317	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
700508006318	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
700508006319	GTPases [General function prediction only]; Region: HflX; COG2262
700508006320	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
700508006321	HflX GTPase family; Region: HflX; cd01878
700508006322	G1 box; other site
700508006323	GTP/Mg2+ binding site [chemical binding]; other site
700508006324	Switch I region; other site
700508006325	G2 box; other site
700508006326	G3 box; other site
700508006327	Switch II region; other site
700508006328	G4 box; other site
700508006329	G5 box; other site
700508006330	PE-PPE domain; Region: PE-PPE; pfam08237
700508006331	thiolase; Provisional; Region: PRK06158
700508006332	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508006333	active site
700508006334	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
700508006335	DUF35 OB-fold domain; Region: DUF35; pfam01796
700508006336	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508006337	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508006338	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508006339	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
700508006340	active site
700508006341	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508006342	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508006343	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
700508006344	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
700508006345	molybdopterin cofactor binding site [chemical binding]; other site
700508006346	substrate binding site [chemical binding]; other site
700508006347	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
700508006348	molybdopterin cofactor binding site; other site
700508006349	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508006350	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508006351	active site
700508006352	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
700508006353	LGFP repeat; Region: LGFP; pfam08310
700508006354	LGFP repeat; Region: LGFP; pfam08310
700508006355	LGFP repeat; Region: LGFP; pfam08310
700508006356	LGFP repeat; Region: LGFP; pfam08310
700508006357	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
700508006358	Catalytic site [active]
700508006359	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
700508006360	MarR family; Region: MarR_2; cl17246
700508006361	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700508006362	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
700508006363	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
700508006364	ATP cone domain; Region: ATP-cone; pfam03477
700508006365	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
700508006366	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508006367	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
700508006368	PAC2 family; Region: PAC2; pfam09754
700508006369	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
700508006370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508006371	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508006372	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
700508006373	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
700508006374	Domain of unknown function DUF21; Region: DUF21; pfam01595
700508006375	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700508006376	Transporter associated domain; Region: CorC_HlyC; pfam03471
700508006377	Domain of unknown function DUF21; Region: DUF21; pfam01595
700508006378	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700508006379	FOG: CBS domain [General function prediction only]; Region: COG0517
700508006380	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
700508006381	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
700508006382	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
700508006383	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
700508006384	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
700508006385	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
700508006386	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
700508006387	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508006388	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
700508006389	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508006390	DNA binding residues [nucleotide binding]
700508006391	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
700508006392	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
700508006393	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
700508006394	Protein of unknown function (DUF952); Region: DUF952; cl01393
700508006395	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508006396	NAD(P) binding site [chemical binding]; other site
700508006397	active site
700508006398	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
700508006399	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508006400	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
700508006401	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508006402	DNA binding residues [nucleotide binding]
700508006403	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
700508006404	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
700508006405	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
700508006406	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
700508006407	trimer interface [polypeptide binding]; other site
700508006408	active site
700508006409	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
700508006410	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
700508006411	generic binding surface II; other site
700508006412	ssDNA binding site; other site
700508006413	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
700508006414	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
700508006415	TrkA-N domain; Region: TrkA_N; pfam02254
700508006416	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
700508006417	TrkA-N domain; Region: TrkA_N; pfam02254
700508006418	TrkA-C domain; Region: TrkA_C; pfam02080
700508006419	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
700508006420	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
700508006421	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508006422	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508006423	non-specific DNA binding site [nucleotide binding]; other site
700508006424	salt bridge; other site
700508006425	sequence-specific DNA binding site [nucleotide binding]; other site
700508006426	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508006427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508006428	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
700508006429	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
700508006430	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
700508006431	TPP-binding site; other site
700508006432	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700508006433	PYR/PP interface [polypeptide binding]; other site
700508006434	dimer interface [polypeptide binding]; other site
700508006435	TPP binding site [chemical binding]; other site
700508006436	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700508006437	Phosphate-starvation-inducible E; Region: PsiE; cl01264
700508006438	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
700508006439	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
700508006440	catalytic site [active]
700508006441	putative active site [active]
700508006442	putative substrate binding site [chemical binding]; other site
700508006443	Helicase and RNase D C-terminal; Region: HRDC; smart00341
700508006444	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
700508006445	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
700508006446	substrate binding site [chemical binding]; other site
700508006447	active site
700508006448	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
700508006449	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508006450	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508006451	metal binding site [ion binding]; metal-binding site
700508006452	active site
700508006453	I-site; other site
700508006454	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
700508006455	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
700508006456	SelR domain; Region: SelR; pfam01641
700508006457	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
700508006458	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508006459	TAP-like protein; Region: Abhydrolase_4; pfam08386
700508006460	hypothetical protein; Provisional; Region: PRK14059
700508006461	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
700508006462	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
700508006463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
700508006464	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700508006465	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508006466	Coenzyme A binding pocket [chemical binding]; other site
700508006467	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
700508006468	Clp amino terminal domain; Region: Clp_N; pfam02861
700508006469	Clp amino terminal domain; Region: Clp_N; pfam02861
700508006470	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
700508006471	hydrophobic ligand binding site; other site
700508006472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508006473	S-adenosylmethionine binding site [chemical binding]; other site
700508006474	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
700508006475	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
700508006476	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
700508006477	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700508006478	hydrophobic ligand binding site; other site
700508006479	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
700508006480	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508006481	GAF domain; Region: GAF_2; pfam13185
700508006482	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508006483	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700508006484	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
700508006485	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700508006486	active site
700508006487	Int/Topo IB signature motif; other site
700508006488	DNA binding site [nucleotide binding]
700508006489	putative transposase OrfB; Reviewed; Region: PHA02517
700508006490	Integrase core domain; Region: rve; pfam00665
700508006491	Integrase core domain; Region: rve_3; cl15866
700508006492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
700508006493	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
700508006494	AAA domain; Region: AAA_25; pfam13481
700508006495	ATP binding site [chemical binding]; other site
700508006496	Walker B motif; other site
700508006497	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
700508006498	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
700508006499	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
700508006500	putative NAD(P) binding site [chemical binding]; other site
700508006501	putative substrate binding site [chemical binding]; other site
700508006502	catalytic Zn binding site [ion binding]; other site
700508006503	structural Zn binding site [ion binding]; other site
700508006504	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700508006505	PAS domain; Region: PAS_9; pfam13426
700508006506	putative active site [active]
700508006507	heme pocket [chemical binding]; other site
700508006508	PAS domain S-box; Region: sensory_box; TIGR00229
700508006509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700508006510	putative active site [active]
700508006511	heme pocket [chemical binding]; other site
700508006512	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508006513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508006514	metal binding site [ion binding]; metal-binding site
700508006515	active site
700508006516	I-site; other site
700508006517	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
700508006518	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
700508006519	4Fe-4S binding domain; Region: Fer4; cl02805
700508006520	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508006521	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
700508006522	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700508006523	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
700508006524	putative active site [active]
700508006525	putative FMN binding site [chemical binding]; other site
700508006526	putative substrate binding site [chemical binding]; other site
700508006527	putative catalytic residue [active]
700508006528	putative phosphoketolase; Provisional; Region: PRK05261
700508006529	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
700508006530	TPP-binding site; other site
700508006531	XFP C-terminal domain; Region: XFP_C; pfam09363
700508006532	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
700508006533	homodimer interface [polypeptide binding]; other site
700508006534	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
700508006535	active site pocket [active]
700508006536	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
700508006537	Phosphotransferase enzyme family; Region: APH; pfam01636
700508006538	putative active site [active]
700508006539	putative substrate binding site [chemical binding]; other site
700508006540	ATP binding site [chemical binding]; other site
700508006541	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
700508006542	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508006543	CoenzymeA binding site [chemical binding]; other site
700508006544	subunit interaction site [polypeptide binding]; other site
700508006545	PHB binding site; other site
700508006546	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
700508006547	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
700508006548	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
700508006549	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
700508006550	active site
700508006551	dimer interface [polypeptide binding]; other site
700508006552	motif 1; other site
700508006553	motif 2; other site
700508006554	motif 3; other site
700508006555	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
700508006556	anticodon binding site; other site
700508006557	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
700508006558	nucleotide binding site/active site [active]
700508006559	HIT family signature motif; other site
700508006560	catalytic residue [active]
700508006561	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
700508006562	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
700508006563	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
700508006564	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
700508006565	putative acyl-acceptor binding pocket; other site
700508006566	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508006567	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700508006568	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
700508006569	nudix motif; other site
700508006570	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
700508006571	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
700508006572	active site
700508006573	multimer interface [polypeptide binding]; other site
700508006574	acyl-CoA thioesterase II; Region: tesB; TIGR00189
700508006575	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
700508006576	active site
700508006577	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
700508006578	catalytic triad [active]
700508006579	dimer interface [polypeptide binding]; other site
700508006580	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
700508006581	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143
700508006582	predicted active site [active]
700508006583	catalytic triad [active]
700508006584	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508006585	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508006586	active site
700508006587	hypothetical protein; Validated; Region: PRK00110
700508006588	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508006589	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700508006590	NAD(P) binding site [chemical binding]; other site
700508006591	active site
700508006592	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
700508006593	active site
700508006594	putative DNA-binding cleft [nucleotide binding]; other site
700508006595	dimer interface [polypeptide binding]; other site
700508006596	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
700508006597	RuvA N terminal domain; Region: RuvA_N; pfam01330
700508006598	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
700508006599	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
700508006600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508006601	Walker A motif; other site
700508006602	ATP binding site [chemical binding]; other site
700508006603	Walker B motif; other site
700508006604	arginine finger; other site
700508006605	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
700508006606	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
700508006607	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
700508006608	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508006609	inhibitor-cofactor binding pocket; inhibition site
700508006610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508006611	catalytic residue [active]
700508006612	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
700508006613	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
700508006614	Protein export membrane protein; Region: SecD_SecF; cl14618
700508006615	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
700508006616	Protein export membrane protein; Region: SecD_SecF; pfam02355
700508006617	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
700508006618	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
700508006619	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700508006620	active site
700508006621	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
700508006622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700508006623	Zn2+ binding site [ion binding]; other site
700508006624	Mg2+ binding site [ion binding]; other site
700508006625	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
700508006626	synthetase active site [active]
700508006627	NTP binding site [chemical binding]; other site
700508006628	metal binding site [ion binding]; metal-binding site
700508006629	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
700508006630	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
700508006631	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700508006632	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
700508006633	active site
700508006634	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
700508006635	active site
700508006636	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700508006637	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
700508006638	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
700508006639	dimer interface [polypeptide binding]; other site
700508006640	motif 1; other site
700508006641	active site
700508006642	motif 2; other site
700508006643	motif 3; other site
700508006644	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
700508006645	anticodon binding site; other site
700508006646	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
700508006647	putative active site [active]
700508006648	dimerization interface [polypeptide binding]; other site
700508006649	putative tRNAtyr binding site [nucleotide binding]; other site
700508006650	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
700508006651	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
700508006652	Walker A/P-loop; other site
700508006653	ATP binding site [chemical binding]; other site
700508006654	Q-loop/lid; other site
700508006655	ABC transporter signature motif; other site
700508006656	Walker B; other site
700508006657	D-loop; other site
700508006658	H-loop/switch region; other site
700508006659	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
700508006660	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
700508006661	Walker A/P-loop; other site
700508006662	ATP binding site [chemical binding]; other site
700508006663	Q-loop/lid; other site
700508006664	ABC transporter signature motif; other site
700508006665	Walker B; other site
700508006666	D-loop; other site
700508006667	H-loop/switch region; other site
700508006668	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
700508006669	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
700508006670	TM-ABC transporter signature motif; other site
700508006671	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
700508006672	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700508006673	TM-ABC transporter signature motif; other site
700508006674	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700508006675	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
700508006676	putative ligand binding site [chemical binding]; other site
700508006677	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
700508006678	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508006679	FeS/SAM binding site; other site
700508006680	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508006681	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508006682	active site
700508006683	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508006684	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508006685	Predicted amidohydrolase [General function prediction only]; Region: COG0388
700508006686	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
700508006687	active site
700508006688	catalytic triad [active]
700508006689	dimer interface [polypeptide binding]; other site
700508006690	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
700508006691	DinB superfamily; Region: DinB_2; pfam12867
700508006692	Predicted metalloprotease [General function prediction only]; Region: COG2321
700508006693	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
700508006694	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
700508006695	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508006696	substrate binding pocket [chemical binding]; other site
700508006697	catalytic triad [active]
700508006698	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
700508006699	putative hydrophobic ligand binding site [chemical binding]; other site
700508006700	protein interface [polypeptide binding]; other site
700508006701	gate; other site
700508006702	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
700508006703	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
700508006704	dimer interface [polypeptide binding]; other site
700508006705	anticodon binding site; other site
700508006706	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
700508006707	homodimer interface [polypeptide binding]; other site
700508006708	motif 1; other site
700508006709	active site
700508006710	motif 2; other site
700508006711	GAD domain; Region: GAD; pfam02938
700508006712	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700508006713	active site
700508006714	motif 3; other site
700508006715	Domain of unknown function (DUF385); Region: DUF385; pfam04075
700508006716	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
700508006717	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508006718	dimer interface [polypeptide binding]; other site
700508006719	active site
700508006720	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
700508006721	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
700508006722	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
700508006723	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
700508006724	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
700508006725	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
700508006726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
700508006727	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
700508006728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
700508006729	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
700508006730	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508006731	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
700508006732	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
700508006733	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
700508006734	recombination factor protein RarA; Reviewed; Region: PRK13342
700508006735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508006736	Walker A motif; other site
700508006737	ATP binding site [chemical binding]; other site
700508006738	Walker B motif; other site
700508006739	arginine finger; other site
700508006740	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
700508006741	Uncharacterized conserved protein [Function unknown]; Region: COG0432
700508006742	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
700508006743	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
700508006744	motif 1; other site
700508006745	active site
700508006746	motif 2; other site
700508006747	motif 3; other site
700508006748	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
700508006749	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
700508006750	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
700508006751	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
700508006752	dimerization interface [polypeptide binding]; other site
700508006753	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
700508006754	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
700508006755	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
700508006756	shikimate binding site; other site
700508006757	NAD(P) binding site [chemical binding]; other site
700508006758	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
700508006759	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
700508006760	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
700508006761	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700508006762	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700508006763	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
700508006764	dimerization interface [polypeptide binding]; other site
700508006765	ligand binding site [chemical binding]; other site
700508006766	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
700508006767	classical (c) SDRs; Region: SDR_c; cd05233
700508006768	NAD(P) binding site [chemical binding]; other site
700508006769	active site
700508006770	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
700508006771	benzoate transport; Region: 2A0115; TIGR00895
700508006772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508006773	putative substrate translocation pore; other site
700508006774	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
700508006775	Strictosidine synthase; Region: Str_synth; pfam03088
700508006776	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
700508006777	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
700508006778	Tetramer interface [polypeptide binding]; other site
700508006779	active site
700508006780	FMN-binding site [chemical binding]; other site
700508006781	shikimate kinase; Reviewed; Region: aroK; PRK00131
700508006782	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
700508006783	ADP binding site [chemical binding]; other site
700508006784	magnesium binding site [ion binding]; other site
700508006785	putative shikimate binding site; other site
700508006786	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
700508006787	active site
700508006788	dimer interface [polypeptide binding]; other site
700508006789	metal binding site [ion binding]; metal-binding site
700508006790	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
700508006791	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
700508006792	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
700508006793	active site
700508006794	elongation factor P; Validated; Region: PRK00529
700508006795	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
700508006796	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
700508006797	RNA binding site [nucleotide binding]; other site
700508006798	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
700508006799	RNA binding site [nucleotide binding]; other site
700508006800	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
700508006801	putative RNA binding site [nucleotide binding]; other site
700508006802	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
700508006803	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
700508006804	DNA-binding site [nucleotide binding]; DNA binding site
700508006805	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508006806	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508006807	homodimer interface [polypeptide binding]; other site
700508006808	catalytic residue [active]
700508006809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508006810	Coenzyme A binding pocket [chemical binding]; other site
700508006811	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700508006812	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508006813	DNA-binding site [nucleotide binding]; DNA binding site
700508006814	UTRA domain; Region: UTRA; pfam07702
700508006815	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
700508006816	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
700508006817	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
700508006818	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
700508006819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
700508006820	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
700508006821	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
700508006822	Walker A/P-loop; other site
700508006823	ATP binding site [chemical binding]; other site
700508006824	Q-loop/lid; other site
700508006825	ABC transporter signature motif; other site
700508006826	Walker B; other site
700508006827	D-loop; other site
700508006828	H-loop/switch region; other site
700508006829	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
700508006830	L-aspartate oxidase; Provisional; Region: PRK06175
700508006831	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
700508006832	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508006833	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508006834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508006835	metabolite-proton symporter; Region: 2A0106; TIGR00883
700508006836	putative substrate translocation pore; other site
700508006837	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
700508006838	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700508006839	active site
700508006840	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
700508006841	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
700508006842	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
700508006843	dihydroorotase; Validated; Region: pyrC; PRK09357
700508006844	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508006845	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
700508006846	active site
700508006847	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
700508006848	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
700508006849	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
700508006850	catalytic site [active]
700508006851	subunit interface [polypeptide binding]; other site
700508006852	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
700508006853	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700508006854	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508006855	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
700508006856	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700508006857	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508006858	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
700508006859	IMP binding site; other site
700508006860	dimer interface [polypeptide binding]; other site
700508006861	interdomain contacts; other site
700508006862	partial ornithine binding site; other site
700508006863	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
700508006864	active site
700508006865	dimer interface [polypeptide binding]; other site
700508006866	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
700508006867	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
700508006868	catalytic site [active]
700508006869	G-X2-G-X-G-K; other site
700508006870	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
700508006871	S-adenosylmethionine synthetase; Validated; Region: PRK05250
700508006872	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
700508006873	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
700508006874	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
700508006875	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508006876	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508006877	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508006878	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508006879	substrate binding pocket [chemical binding]; other site
700508006880	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508006881	Predicted membrane protein [Function unknown]; Region: COG3714
700508006882	primosome assembly protein PriA; Provisional; Region: PRK14873
700508006883	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
700508006884	LemA family; Region: LemA; cl00742
700508006885	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
700508006886	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
700508006887	putative active site [active]
700508006888	substrate binding site [chemical binding]; other site
700508006889	putative cosubstrate binding site; other site
700508006890	catalytic site [active]
700508006891	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
700508006892	substrate binding site [chemical binding]; other site
700508006893	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
700508006894	putative RNA binding site [nucleotide binding]; other site
700508006895	16S rRNA methyltransferase B; Provisional; Region: PRK14902
700508006896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508006897	S-adenosylmethionine binding site [chemical binding]; other site
700508006898	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
700508006899	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
700508006900	substrate binding site [chemical binding]; other site
700508006901	hexamer interface [polypeptide binding]; other site
700508006902	metal binding site [ion binding]; metal-binding site
700508006903	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
700508006904	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
700508006905	catalytic motif [active]
700508006906	Zn binding site [ion binding]; other site
700508006907	RibD C-terminal domain; Region: RibD_C; pfam01872
700508006908	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
700508006909	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
700508006910	putative catalytic site [active]
700508006911	putative metal binding site [ion binding]; other site
700508006912	putative phosphate binding site [ion binding]; other site
700508006913	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
700508006914	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
700508006915	Ligand binding site; other site
700508006916	Putative Catalytic site; other site
700508006917	DXD motif; other site
700508006918	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700508006919	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700508006920	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
700508006921	active site
700508006922	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
700508006923	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
700508006924	active site
700508006925	catalytic residues [active]
700508006926	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
700508006927	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
700508006928	active site
700508006929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508006930	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700508006931	putative substrate translocation pore; other site
700508006932	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
700508006933	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
700508006934	Lumazine binding domain; Region: Lum_binding; pfam00677
700508006935	Lumazine binding domain; Region: Lum_binding; pfam00677
700508006936	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
700508006937	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
700508006938	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
700508006939	dimerization interface [polypeptide binding]; other site
700508006940	active site
700508006941	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
700508006942	homopentamer interface [polypeptide binding]; other site
700508006943	active site
700508006944	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
700508006945	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700508006946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508006947	Coenzyme A binding pocket [chemical binding]; other site
700508006948	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
700508006949	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826
700508006950	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700508006951	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700508006952	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
700508006953	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
700508006954	GIY-YIG motif/motif A; other site
700508006955	active site
700508006956	catalytic site [active]
700508006957	putative DNA binding site [nucleotide binding]; other site
700508006958	metal binding site [ion binding]; metal-binding site
700508006959	UvrB/uvrC motif; Region: UVR; pfam02151
700508006960	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
700508006961	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
700508006962	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
700508006963	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
700508006964	phosphate binding site [ion binding]; other site
700508006965	putative substrate binding pocket [chemical binding]; other site
700508006966	dimer interface [polypeptide binding]; other site
700508006967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
700508006968	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
700508006969	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700508006970	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700508006971	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
700508006972	Walker A/P-loop; other site
700508006973	ATP binding site [chemical binding]; other site
700508006974	Q-loop/lid; other site
700508006975	ABC transporter signature motif; other site
700508006976	Walker B; other site
700508006977	D-loop; other site
700508006978	H-loop/switch region; other site
700508006979	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127
700508006980	PLD-like domain; Region: PLDc_2; pfam13091
700508006981	putative active site [active]
700508006982	putative catalytic site [active]
700508006983	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_2; cd09128
700508006984	PLD-like domain; Region: PLDc_2; pfam13091
700508006985	putative active site [active]
700508006986	putative catalytic site [active]
700508006987	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
700508006988	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
700508006989	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
700508006990	Phosphoglycerate kinase; Region: PGK; pfam00162
700508006991	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
700508006992	substrate binding site [chemical binding]; other site
700508006993	hinge regions; other site
700508006994	ADP binding site [chemical binding]; other site
700508006995	catalytic site [active]
700508006996	triosephosphate isomerase; Provisional; Region: PRK14567
700508006997	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
700508006998	substrate binding site [chemical binding]; other site
700508006999	dimer interface [polypeptide binding]; other site
700508007000	catalytic triad [active]
700508007001	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
700508007002	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
700508007003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
700508007004	Transposase; Region: DDE_Tnp_ISL3; pfam01610
700508007005	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508007006	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508007007	active site
700508007008	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
700508007009	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
700508007010	putative active site [active]
700508007011	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
700508007012	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
700508007013	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
700508007014	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
700508007015	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
700508007016	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
700508007017	putative active site [active]
700508007018	transaldolase; Provisional; Region: PRK03903
700508007019	catalytic residue [active]
700508007020	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
700508007021	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
700508007022	TPP-binding site [chemical binding]; other site
700508007023	dimer interface [polypeptide binding]; other site
700508007024	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
700508007025	PYR/PP interface [polypeptide binding]; other site
700508007026	dimer interface [polypeptide binding]; other site
700508007027	TPP binding site [chemical binding]; other site
700508007028	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700508007029	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
700508007030	UbiA prenyltransferase family; Region: UbiA; pfam01040
700508007031	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
700508007032	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
700508007033	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
700508007034	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
700508007035	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
700508007036	NADP binding site [chemical binding]; other site
700508007037	dimer interface [polypeptide binding]; other site
700508007038	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508007039	Protein of unknown function (DUF419); Region: DUF419; pfam04237
700508007040	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
700508007041	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508007042	Walker A/P-loop; other site
700508007043	ATP binding site [chemical binding]; other site
700508007044	Q-loop/lid; other site
700508007045	ABC transporter signature motif; other site
700508007046	Walker B; other site
700508007047	D-loop; other site
700508007048	H-loop/switch region; other site
700508007049	TOBE domain; Region: TOBE_2; pfam08402
700508007050	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
700508007051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508007052	dimer interface [polypeptide binding]; other site
700508007053	conserved gate region; other site
700508007054	putative PBP binding loops; other site
700508007055	ABC-ATPase subunit interface; other site
700508007056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508007057	dimer interface [polypeptide binding]; other site
700508007058	conserved gate region; other site
700508007059	putative PBP binding loops; other site
700508007060	ABC-ATPase subunit interface; other site
700508007061	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
700508007062	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
700508007063	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508007064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508007065	NAD(P) binding site [chemical binding]; other site
700508007066	active site
700508007067	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
700508007068	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
700508007069	N- and C-terminal domain interface [polypeptide binding]; other site
700508007070	putative active site [active]
700508007071	putative xylulose binding site [chemical binding]; other site
700508007072	MgATP binding site [chemical binding]; other site
700508007073	putative homodimer interface [polypeptide binding]; other site
700508007074	BtpA family; Region: BtpA; cl00440
700508007075	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
700508007076	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
700508007077	active site
700508007078	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
700508007079	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
700508007080	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
700508007081	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
700508007082	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
700508007083	Protein of unknown function (DUF429); Region: DUF429; cl12046
700508007084	ABC-2 type transporter; Region: ABC2_membrane; cl17235
700508007085	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700508007086	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700508007087	Walker A/P-loop; other site
700508007088	ATP binding site [chemical binding]; other site
700508007089	Q-loop/lid; other site
700508007090	ABC transporter signature motif; other site
700508007091	Walker B; other site
700508007092	D-loop; other site
700508007093	H-loop/switch region; other site
700508007094	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
700508007095	Predicted transcriptional regulator [Transcription]; Region: COG2345
700508007096	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508007097	putative DNA binding site [nucleotide binding]; other site
700508007098	putative Zn2+ binding site [ion binding]; other site
700508007099	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
700508007100	nucleic acid binding site [nucleotide binding]; other site
700508007101	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
700508007102	FeS assembly protein SufB; Region: sufB; TIGR01980
700508007103	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
700508007104	FeS assembly protein SufD; Region: sufD; TIGR01981
700508007105	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
700508007106	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
700508007107	Walker A/P-loop; other site
700508007108	ATP binding site [chemical binding]; other site
700508007109	Q-loop/lid; other site
700508007110	ABC transporter signature motif; other site
700508007111	Walker B; other site
700508007112	D-loop; other site
700508007113	H-loop/switch region; other site
700508007114	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
700508007115	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
700508007116	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508007117	catalytic residue [active]
700508007118	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
700508007119	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
700508007120	trimerization site [polypeptide binding]; other site
700508007121	active site
700508007122	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
700508007123	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
700508007124	active site
700508007125	catalytic residues [active]
700508007126	enoyl-CoA hydratase; Provisional; Region: PRK05864
700508007127	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508007128	substrate binding site [chemical binding]; other site
700508007129	oxyanion hole (OAH) forming residues; other site
700508007130	trimer interface [polypeptide binding]; other site
700508007131	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
700508007132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508007133	Walker A/P-loop; other site
700508007134	ATP binding site [chemical binding]; other site
700508007135	Q-loop/lid; other site
700508007136	ABC transporter signature motif; other site
700508007137	Walker B; other site
700508007138	D-loop; other site
700508007139	H-loop/switch region; other site
700508007140	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700508007141	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508007142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007143	aconitate hydratase; Validated; Region: PRK09277
700508007144	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
700508007145	substrate binding site [chemical binding]; other site
700508007146	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
700508007147	ligand binding site [chemical binding]; other site
700508007148	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
700508007149	substrate binding site [chemical binding]; other site
700508007150	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
700508007151	NlpC/P60 family; Region: NLPC_P60; pfam00877
700508007152	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
700508007153	NlpC/P60 family; Region: NLPC_P60; pfam00877
700508007154	MoxR-like ATPases [General function prediction only]; Region: COG0714
700508007155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508007156	Walker A motif; other site
700508007157	ATP binding site [chemical binding]; other site
700508007158	Walker B motif; other site
700508007159	arginine finger; other site
700508007160	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
700508007161	Protein of unknown function DUF58; Region: DUF58; pfam01882
700508007162	hypothetical protein; Provisional; Region: PRK13685
700508007163	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
700508007164	metal ion-dependent adhesion site (MIDAS); other site
700508007165	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700508007166	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700508007167	active site
700508007168	catalytic tetrad [active]
700508007169	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
700508007170	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508007171	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
700508007172	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
700508007173	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
700508007174	NAD(P) binding site [chemical binding]; other site
700508007175	homotetramer interface [polypeptide binding]; other site
700508007176	homodimer interface [polypeptide binding]; other site
700508007177	active site
700508007178	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
700508007179	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
700508007180	NAD binding site [chemical binding]; other site
700508007181	homotetramer interface [polypeptide binding]; other site
700508007182	homodimer interface [polypeptide binding]; other site
700508007183	substrate binding site [chemical binding]; other site
700508007184	active site
700508007185	ferrochelatase; Reviewed; Region: hemH; PRK00035
700508007186	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
700508007187	C-terminal domain interface [polypeptide binding]; other site
700508007188	active site
700508007189	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
700508007190	active site
700508007191	N-terminal domain interface [polypeptide binding]; other site
700508007192	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
700508007193	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
700508007194	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
700508007195	Uncharacterized conserved protein [Function unknown]; Region: COG0398
700508007196	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
700508007197	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
700508007198	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
700508007199	heterodimer interface [polypeptide binding]; other site
700508007200	substrate interaction site [chemical binding]; other site
700508007201	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
700508007202	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
700508007203	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
700508007204	active site
700508007205	substrate binding site [chemical binding]; other site
700508007206	coenzyme B12 binding site [chemical binding]; other site
700508007207	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
700508007208	B12 binding site [chemical binding]; other site
700508007209	cobalt ligand [ion binding]; other site
700508007210	membrane ATPase/protein kinase; Provisional; Region: PRK09435
700508007211	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
700508007212	Walker A; other site
700508007213	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700508007214	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508007215	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508007216	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
700508007217	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
700508007218	active site
700508007219	Acyl transferase domain; Region: Acyl_transf_1; cl08282
700508007220	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
700508007221	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508007222	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
700508007223	Enoylreductase; Region: PKS_ER; smart00829
700508007224	NAD(P) binding site [chemical binding]; other site
700508007225	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
700508007226	KR domain; Region: KR; pfam08659
700508007227	putative NADP binding site [chemical binding]; other site
700508007228	active site
700508007229	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
700508007230	Condensation domain; Region: Condensation; pfam00668
700508007231	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508007232	acyl-CoA synthetase; Validated; Region: PRK05850
700508007233	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
700508007234	acyl-activating enzyme (AAE) consensus motif; other site
700508007235	active site
700508007236	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
700508007237	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
700508007238	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
700508007239	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
700508007240	homodimer interface [polypeptide binding]; other site
700508007241	active site
700508007242	TDP-binding site; other site
700508007243	acceptor substrate-binding pocket; other site
700508007244	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
700508007245	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
700508007246	HIGH motif; other site
700508007247	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
700508007248	active site
700508007249	KMSKS motif; other site
700508007250	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
700508007251	tRNA binding surface [nucleotide binding]; other site
700508007252	anticodon binding site; other site
700508007253	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700508007254	RNA binding surface [nucleotide binding]; other site
700508007255	lipoprotein signal peptidase; Provisional; Region: PRK14764
700508007256	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
700508007257	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
700508007258	active site
700508007259	Predicted permeases [General function prediction only]; Region: RarD; COG2962
700508007260	Transport protein; Region: actII; TIGR00833
700508007261	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
700508007262	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
700508007263	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
700508007264	mannosyltransferase; Provisional; Region: pimE; PRK13375
700508007265	mannosyltransferase; Provisional; Region: pimE; PRK13375
700508007266	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700508007267	ABC-2 type transporter; Region: ABC2_membrane; cl17235
700508007268	ABC-2 type transporter; Region: ABC2_membrane; cl17235
700508007269	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508007270	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
700508007271	Walker A/P-loop; other site
700508007272	ATP binding site [chemical binding]; other site
700508007273	Q-loop/lid; other site
700508007274	ABC transporter signature motif; other site
700508007275	Walker B; other site
700508007276	D-loop; other site
700508007277	H-loop/switch region; other site
700508007278	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
700508007279	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
700508007280	active site
700508007281	PHP Thumb interface [polypeptide binding]; other site
700508007282	metal binding site [ion binding]; metal-binding site
700508007283	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
700508007284	generic binding surface II; other site
700508007285	generic binding surface I; other site
700508007286	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
700508007287	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
700508007288	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508007289	DNA binding residues [nucleotide binding]
700508007290	threonine dehydratase; Validated; Region: PRK08639
700508007291	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
700508007292	tetramer interface [polypeptide binding]; other site
700508007293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508007294	catalytic residue [active]
700508007295	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
700508007296	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
700508007297	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
700508007298	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
700508007299	catalytic site [active]
700508007300	active site
700508007301	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
700508007302	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
700508007303	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
700508007304	active site
700508007305	catalytic site [active]
700508007306	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
700508007307	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
700508007308	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
700508007309	active site
700508007310	catalytic site [active]
700508007311	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700508007312	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
700508007313	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508007314	inhibitor-cofactor binding pocket; inhibition site
700508007315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508007316	catalytic residue [active]
700508007317	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
700508007318	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
700508007319	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007320	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
700508007321	biotin synthase; Validated; Region: PRK06256
700508007322	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508007323	FeS/SAM binding site; other site
700508007324	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
700508007325	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
700508007326	Secretory lipase; Region: LIP; pfam03583
700508007327	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
700508007328	nudix motif; other site
700508007329	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
700508007330	quinolinate synthetase; Provisional; Region: PRK09375
700508007331	L-aspartate oxidase; Provisional; Region: PRK07804
700508007332	L-aspartate oxidase; Provisional; Region: PRK06175
700508007333	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
700508007334	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
700508007335	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
700508007336	dimerization interface [polypeptide binding]; other site
700508007337	active site
700508007338	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
700508007339	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508007340	NAD(P) binding site [chemical binding]; other site
700508007341	catalytic residues [active]
700508007342	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508007343	Permease; Region: Permease; pfam02405
700508007344	Permease; Region: Permease; pfam02405
700508007345	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508007346	mce related protein; Region: MCE; pfam02470
700508007347	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508007348	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508007349	mce related protein; Region: MCE; pfam02470
700508007350	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508007351	mce related protein; Region: MCE; pfam02470
700508007352	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508007353	mce related protein; Region: MCE; pfam02470
700508007354	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508007355	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508007356	mce related protein; Region: MCE; pfam02470
700508007357	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508007358	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508007359	mce related protein; Region: MCE; pfam02470
700508007360	ferredoxin-NADP+ reductase; Region: PLN02852
700508007361	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508007362	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
700508007363	4Fe-4S binding domain; Region: Fer4; pfam00037
700508007364	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
700508007365	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
700508007366	molybdopterin cofactor binding site; other site
700508007367	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
700508007368	molybdopterin cofactor binding site; other site
700508007369	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
700508007370	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
700508007371	dimer interface [polypeptide binding]; other site
700508007372	acyl-activating enzyme (AAE) consensus motif; other site
700508007373	putative active site [active]
700508007374	AMP binding site [chemical binding]; other site
700508007375	putative CoA binding site [chemical binding]; other site
700508007376	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700508007377	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
700508007378	FMN-binding pocket [chemical binding]; other site
700508007379	flavin binding motif; other site
700508007380	phosphate binding motif [ion binding]; other site
700508007381	beta-alpha-beta structure motif; other site
700508007382	NAD binding pocket [chemical binding]; other site
700508007383	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508007384	catalytic loop [active]
700508007385	iron binding site [ion binding]; other site
700508007386	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508007387	Cytochrome P450; Region: p450; cl12078
700508007388	SCP-2 sterol transfer family; Region: SCP2; cl01225
700508007389	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
700508007390	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
700508007391	catalytic Zn binding site [ion binding]; other site
700508007392	NAD binding site [chemical binding]; other site
700508007393	structural Zn binding site [ion binding]; other site
700508007394	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
700508007395	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508007396	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508007397	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700508007398	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508007399	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508007400	DNA binding residues [nucleotide binding]
700508007401	dimerization interface [polypeptide binding]; other site
700508007402	Protease prsW family; Region: PrsW-protease; pfam13367
700508007403	LysE type translocator; Region: LysE; cl00565
700508007404	Domain of unknown function (DUF385); Region: DUF385; cl04387
700508007405	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
700508007406	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
700508007407	NAD binding site [chemical binding]; other site
700508007408	dimerization interface [polypeptide binding]; other site
700508007409	product binding site; other site
700508007410	substrate binding site [chemical binding]; other site
700508007411	zinc binding site [ion binding]; other site
700508007412	catalytic residues [active]
700508007413	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
700508007414	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508007415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508007416	homodimer interface [polypeptide binding]; other site
700508007417	catalytic residue [active]
700508007418	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
700508007419	putative active site pocket [active]
700508007420	4-fold oligomerization interface [polypeptide binding]; other site
700508007421	metal binding residues [ion binding]; metal-binding site
700508007422	3-fold/trimer interface [polypeptide binding]; other site
700508007423	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
700508007424	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
700508007425	putative active site [active]
700508007426	oxyanion strand; other site
700508007427	catalytic triad [active]
700508007428	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
700508007429	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
700508007430	catalytic residues [active]
700508007431	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
700508007432	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
700508007433	active site
700508007434	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
700508007435	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
700508007436	substrate binding site [chemical binding]; other site
700508007437	glutamase interaction surface [polypeptide binding]; other site
700508007438	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
700508007439	Methyltransferase domain; Region: Methyltransf_26; pfam13659
700508007440	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
700508007441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508007442	Walker A/P-loop; other site
700508007443	ATP binding site [chemical binding]; other site
700508007444	Q-loop/lid; other site
700508007445	ABC transporter signature motif; other site
700508007446	Walker B; other site
700508007447	D-loop; other site
700508007448	H-loop/switch region; other site
700508007449	transcriptional regulator NanR; Provisional; Region: PRK03837
700508007450	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508007451	DNA-binding site [nucleotide binding]; DNA binding site
700508007452	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
700508007453	2-isopropylmalate synthase; Validated; Region: PRK03739
700508007454	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
700508007455	active site
700508007456	catalytic residues [active]
700508007457	metal binding site [ion binding]; metal-binding site
700508007458	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
700508007459	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
700508007460	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
700508007461	catalytic triad [active]
700508007462	anthranilate synthase component I; Provisional; Region: PRK13571
700508007463	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
700508007464	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
700508007465	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
700508007466	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
700508007467	active site
700508007468	ribulose/triose binding site [chemical binding]; other site
700508007469	phosphate binding site [ion binding]; other site
700508007470	substrate (anthranilate) binding pocket [chemical binding]; other site
700508007471	product (indole) binding pocket [chemical binding]; other site
700508007472	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
700508007473	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
700508007474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508007475	catalytic residue [active]
700508007476	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
700508007477	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
700508007478	substrate binding site [chemical binding]; other site
700508007479	active site
700508007480	catalytic residues [active]
700508007481	heterodimer interface [polypeptide binding]; other site
700508007482	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
700508007483	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508007484	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508007485	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
700508007486	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
700508007487	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
700508007488	[4Fe-4S] binding site [ion binding]; other site
700508007489	molybdopterin cofactor binding site; other site
700508007490	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
700508007491	molybdopterin cofactor binding site; other site
700508007492	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
700508007493	Flavodoxin; Region: Flavodoxin_1; pfam00258
700508007494	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
700508007495	FAD binding pocket [chemical binding]; other site
700508007496	FAD binding motif [chemical binding]; other site
700508007497	catalytic residues [active]
700508007498	NAD binding pocket [chemical binding]; other site
700508007499	phosphate binding motif [ion binding]; other site
700508007500	beta-alpha-beta structure motif; other site
700508007501	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
700508007502	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
700508007503	putative ligand binding residues [chemical binding]; other site
700508007504	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
700508007505	Methyltransferase domain; Region: Methyltransf_18; pfam12847
700508007506	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
700508007507	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508007508	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508007509	sequence-specific DNA binding site [nucleotide binding]; other site
700508007510	salt bridge; other site
700508007511	hypothetical protein; Provisional; Region: PRK07906
700508007512	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
700508007513	putative metal binding site [ion binding]; other site
700508007514	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
700508007515	substrate binding site [chemical binding]; other site
700508007516	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
700508007517	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
700508007518	quinone interaction residues [chemical binding]; other site
700508007519	active site
700508007520	catalytic residues [active]
700508007521	FMN binding site [chemical binding]; other site
700508007522	substrate binding site [chemical binding]; other site
700508007523	Uncharacterized conserved protein [Function unknown]; Region: COG3391
700508007524	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
700508007525	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508007526	catalytic core [active]
700508007527	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
700508007528	conserved hypothetical protein; Region: TIGR03843
700508007529	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
700508007530	active site
700508007531	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
700508007532	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
700508007533	active site
700508007534	HIGH motif; other site
700508007535	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700508007536	active site
700508007537	KMSKS motif; other site
700508007538	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
700508007539	putative tRNA binding surface [nucleotide binding]; other site
700508007540	short chain dehydrogenase; Provisional; Region: PRK05872
700508007541	classical (c) SDRs; Region: SDR_c; cd05233
700508007542	NAD(P) binding site [chemical binding]; other site
700508007543	active site
700508007544	PAC2 family; Region: PAC2; pfam09754
700508007545	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
700508007546	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
700508007547	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
700508007548	substrate binding pocket [chemical binding]; other site
700508007549	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
700508007550	B12 binding site [chemical binding]; other site
700508007551	cobalt ligand [ion binding]; other site
700508007552	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
700508007553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508007554	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700508007555	NAD(P) binding site [chemical binding]; other site
700508007556	active site
700508007557	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
700508007558	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508007559	motif II; other site
700508007560	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
700508007561	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
700508007562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508007563	putative substrate translocation pore; other site
700508007564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508007565	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
700508007566	homodimer interface [polypeptide binding]; other site
700508007567	putative metal binding site [ion binding]; other site
700508007568	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
700508007569	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
700508007570	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
700508007571	Predicted membrane protein [Function unknown]; Region: COG3918
700508007572	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508007573	mercuric reductase; Validated; Region: PRK06370
700508007574	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508007575	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
700508007576	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508007577	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007578	Ecdysteroid kinase; Region: EcKinase; cl17738
700508007579	Phosphotransferase enzyme family; Region: APH; pfam01636
700508007580	SnoaL-like domain; Region: SnoaL_4; pfam13577
700508007581	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
700508007582	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
700508007583	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
700508007584	putative hydrophobic ligand binding site [chemical binding]; other site
700508007585	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508007586	dimerization interface [polypeptide binding]; other site
700508007587	putative DNA binding site [nucleotide binding]; other site
700508007588	putative Zn2+ binding site [ion binding]; other site
700508007589	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
700508007590	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
700508007591	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
700508007592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508007593	S-adenosylmethionine binding site [chemical binding]; other site
700508007594	proteasome ATPase; Region: pup_AAA; TIGR03689
700508007595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508007596	Walker A motif; other site
700508007597	ATP binding site [chemical binding]; other site
700508007598	Walker B motif; other site
700508007599	arginine finger; other site
700508007600	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508007601	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508007602	putative DNA binding site [nucleotide binding]; other site
700508007603	dimerization interface [polypeptide binding]; other site
700508007604	putative Zn2+ binding site [ion binding]; other site
700508007605	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
700508007606	putative dimerization interface [polypeptide binding]; other site
700508007607	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
700508007608	EamA-like transporter family; Region: EamA; pfam00892
700508007609	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508007610	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508007611	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700508007612	dimerization interface [polypeptide binding]; other site
700508007613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508007614	dimer interface [polypeptide binding]; other site
700508007615	phosphorylation site [posttranslational modification]
700508007616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508007617	ATP binding site [chemical binding]; other site
700508007618	Mg2+ binding site [ion binding]; other site
700508007619	G-X-G motif; other site
700508007620	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508007621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508007622	active site
700508007623	phosphorylation site [posttranslational modification]
700508007624	intermolecular recognition site; other site
700508007625	dimerization interface [polypeptide binding]; other site
700508007626	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508007627	DNA binding site [nucleotide binding]
700508007628	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508007629	Coenzyme A binding pocket [chemical binding]; other site
700508007630	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
700508007631	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508007632	inhibitor-cofactor binding pocket; inhibition site
700508007633	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508007634	catalytic residue [active]
700508007635	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
700508007636	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
700508007637	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
700508007638	Pup-like protein; Region: Pup; cl05289
700508007639	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
700508007640	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
700508007641	active site
700508007642	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
700508007643	Proteasome subunit; Region: Proteasome; pfam00227
700508007644	active site
700508007645	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
700508007646	Predicted transcriptional regulator [Transcription]; Region: COG2378
700508007647	WYL domain; Region: WYL; pfam13280
700508007648	Predicted transcriptional regulator [Transcription]; Region: COG2378
700508007649	WYL domain; Region: WYL; pfam13280
700508007650	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
700508007651	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
700508007652	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
700508007653	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
700508007654	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508007655	ATP binding site [chemical binding]; other site
700508007656	putative Mg++ binding site [ion binding]; other site
700508007657	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508007658	nucleotide binding region [chemical binding]; other site
700508007659	ATP-binding site [chemical binding]; other site
700508007660	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
700508007661	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
700508007662	5'-3' exonuclease; Region: 53EXOc; smart00475
700508007663	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
700508007664	active site
700508007665	metal binding site 1 [ion binding]; metal-binding site
700508007666	putative 5' ssDNA interaction site; other site
700508007667	metal binding site 3; metal-binding site
700508007668	metal binding site 2 [ion binding]; metal-binding site
700508007669	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
700508007670	putative DNA binding site [nucleotide binding]; other site
700508007671	putative metal binding site [ion binding]; other site
700508007672	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
700508007673	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
700508007674	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
700508007675	active site
700508007676	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
700508007677	short chain dehydrogenase; Provisional; Region: PRK07024
700508007678	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508007679	NAD(P) binding site [chemical binding]; other site
700508007680	active site
700508007681	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
700508007682	active site
700508007683	putative homodimer interface [polypeptide binding]; other site
700508007684	SAM binding site [chemical binding]; other site
700508007685	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
700508007686	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
700508007687	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
700508007688	active site
700508007689	homodimer interface [polypeptide binding]; other site
700508007690	SAM binding site [chemical binding]; other site
700508007691	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
700508007692	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
700508007693	Phosphotransferase enzyme family; Region: APH; pfam01636
700508007694	Ecdysteroid kinase; Region: EcKinase; cl17738
700508007695	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
700508007696	active site
700508007697	SAM binding site [chemical binding]; other site
700508007698	homodimer interface [polypeptide binding]; other site
700508007699	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
700508007700	active site
700508007701	SAM binding site [chemical binding]; other site
700508007702	homodimer interface [polypeptide binding]; other site
700508007703	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
700508007704	Precorrin-8X methylmutase; Region: CbiC; pfam02570
700508007705	precorrin-3B synthase; Region: CobG; TIGR02435
700508007706	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
700508007707	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
700508007708	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
700508007709	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
700508007710	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
700508007711	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
700508007712	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
700508007713	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
700508007714	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
700508007715	putative active site [active]
700508007716	putative substrate binding site [chemical binding]; other site
700508007717	putative cosubstrate binding site; other site
700508007718	catalytic site [active]
700508007719	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
700508007720	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508007721	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007722	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
700508007723	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
700508007724	[2Fe-2S] cluster binding site [ion binding]; other site
700508007725	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
700508007726	putative alpha subunit interface [polypeptide binding]; other site
700508007727	putative active site [active]
700508007728	putative substrate binding site [chemical binding]; other site
700508007729	Fe binding site [ion binding]; other site
700508007730	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
700508007731	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
700508007732	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508007733	active site
700508007734	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
700508007735	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
700508007736	putative active site [active]
700508007737	catalytic triad [active]
700508007738	putative dimer interface [polypeptide binding]; other site
700508007739	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
700508007740	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
700508007741	Ligand binding site; other site
700508007742	Putative Catalytic site; other site
700508007743	DXD motif; other site
700508007744	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
700508007745	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
700508007746	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508007747	substrate binding pocket [chemical binding]; other site
700508007748	catalytic triad [active]
700508007749	Ecdysteroid kinase; Region: EcKinase; cl17738
700508007750	Phosphotransferase enzyme family; Region: APH; pfam01636
700508007751	hypothetical protein; Provisional; Region: PRK02237
700508007752	Transcriptional regulators [Transcription]; Region: FadR; COG2186
700508007753	FCD domain; Region: FCD; pfam07729
700508007754	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
700508007755	AAA domain; Region: AAA_33; pfam13671
700508007756	ATP-binding site [chemical binding]; other site
700508007757	Gluconate-6-phosphate binding site [chemical binding]; other site
700508007758	GntP family permease; Region: GntP_permease; pfam02447
700508007759	fructuronate transporter; Provisional; Region: PRK10034; cl15264
700508007760	RDD family; Region: RDD; pfam06271
700508007761	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
700508007762	FMN binding site [chemical binding]; other site
700508007763	dimer interface [polypeptide binding]; other site
700508007764	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
700508007765	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
700508007766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508007767	dimer interface [polypeptide binding]; other site
700508007768	conserved gate region; other site
700508007769	putative PBP binding loops; other site
700508007770	ABC-ATPase subunit interface; other site
700508007771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508007772	dimer interface [polypeptide binding]; other site
700508007773	conserved gate region; other site
700508007774	putative PBP binding loops; other site
700508007775	ABC-ATPase subunit interface; other site
700508007776	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
700508007777	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
700508007778	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
700508007779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508007780	Walker A/P-loop; other site
700508007781	ATP binding site [chemical binding]; other site
700508007782	Q-loop/lid; other site
700508007783	ABC transporter signature motif; other site
700508007784	Walker B; other site
700508007785	D-loop; other site
700508007786	H-loop/switch region; other site
700508007787	TOBE domain; Region: TOBE_2; pfam08402
700508007788	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
700508007789	Epoxide hydrolase N terminus; Region: EHN; pfam06441
700508007790	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508007791	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
700508007792	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
700508007793	active site
700508007794	non-prolyl cis peptide bond; other site
700508007795	YaeQ protein; Region: YaeQ; pfam07152
700508007796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508007797	dimer interface [polypeptide binding]; other site
700508007798	conserved gate region; other site
700508007799	ABC-ATPase subunit interface; other site
700508007800	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
700508007801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508007802	Walker A/P-loop; other site
700508007803	ATP binding site [chemical binding]; other site
700508007804	Q-loop/lid; other site
700508007805	ABC transporter signature motif; other site
700508007806	Walker B; other site
700508007807	D-loop; other site
700508007808	H-loop/switch region; other site
700508007809	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
700508007810	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
700508007811	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
700508007812	active site
700508007813	non-prolyl cis peptide bond; other site
700508007814	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
700508007815	short chain dehydrogenase; Validated; Region: PRK08264
700508007816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508007817	NAD(P) binding site [chemical binding]; other site
700508007818	active site
700508007819	Predicted transcriptional regulators [Transcription]; Region: COG1733
700508007820	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700508007821	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508007822	Ligand Binding Site [chemical binding]; other site
700508007823	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508007824	Ligand Binding Site [chemical binding]; other site
700508007825	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508007826	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700508007827	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508007828	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700508007829	Histidine kinase; Region: HisKA_3; pfam07730
700508007830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508007831	ATP binding site [chemical binding]; other site
700508007832	Mg2+ binding site [ion binding]; other site
700508007833	G-X-G motif; other site
700508007834	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700508007835	FMN binding site [chemical binding]; other site
700508007836	substrate binding site [chemical binding]; other site
700508007837	putative catalytic residue [active]
700508007838	Cutinase; Region: Cutinase; pfam01083
700508007839	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
700508007840	putative active site [active]
700508007841	putative metal binding site [ion binding]; other site
700508007842	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700508007843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
700508007844	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
700508007845	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508007846	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508007847	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
700508007848	putative dimerization interface [polypeptide binding]; other site
700508007849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
700508007850	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
700508007851	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
700508007852	Walker A/P-loop; other site
700508007853	ATP binding site [chemical binding]; other site
700508007854	Q-loop/lid; other site
700508007855	ABC transporter signature motif; other site
700508007856	Walker B; other site
700508007857	D-loop; other site
700508007858	H-loop/switch region; other site
700508007859	TOBE domain; Region: TOBE_2; pfam08402
700508007860	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
700508007861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508007862	dimer interface [polypeptide binding]; other site
700508007863	conserved gate region; other site
700508007864	putative PBP binding loops; other site
700508007865	ABC-ATPase subunit interface; other site
700508007866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508007867	ABC-ATPase subunit interface; other site
700508007868	putative PBP binding loops; other site
700508007869	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
700508007870	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
700508007871	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
700508007872	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
700508007873	allantoinase; Region: allantoinase; TIGR03178
700508007874	active site
700508007875	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
700508007876	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
700508007877	Na binding site [ion binding]; other site
700508007878	putative substrate binding site [chemical binding]; other site
700508007879	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
700508007880	hypothetical protein; Provisional; Region: PRK11171
700508007881	Cupin domain; Region: Cupin_2; pfam07883
700508007882	Cupin domain; Region: Cupin_2; cl17218
700508007883	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
700508007884	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
700508007885	Transcriptional regulator [Transcription]; Region: IclR; COG1414
700508007886	Bacterial transcriptional regulator; Region: IclR; pfam01614
700508007887	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508007888	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007889	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
700508007890	active site clefts [active]
700508007891	zinc binding site [ion binding]; other site
700508007892	dimer interface [polypeptide binding]; other site
700508007893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
700508007894	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
700508007895	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
700508007896	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
700508007897	dimerization interface [polypeptide binding]; other site
700508007898	putative Zn2+ binding site [ion binding]; other site
700508007899	putative DNA binding site [nucleotide binding]; other site
700508007900	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508007901	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
700508007902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007903	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700508007904	Sulfatase; Region: Sulfatase; pfam00884
700508007905	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
700508007906	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508007907	Walker A/P-loop; other site
700508007908	ATP binding site [chemical binding]; other site
700508007909	Q-loop/lid; other site
700508007910	ABC transporter signature motif; other site
700508007911	Walker B; other site
700508007912	D-loop; other site
700508007913	H-loop/switch region; other site
700508007914	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508007915	Walker A/P-loop; other site
700508007916	ATP binding site [chemical binding]; other site
700508007917	Q-loop/lid; other site
700508007918	ABC transporter signature motif; other site
700508007919	Walker B; other site
700508007920	D-loop; other site
700508007921	H-loop/switch region; other site
700508007922	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
700508007923	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700508007924	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
700508007925	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
700508007926	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
700508007927	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
700508007928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508007929	putative substrate translocation pore; other site
700508007930	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
700508007931	short chain dehydrogenase; Validated; Region: PRK08264
700508007932	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508007933	NAD(P) binding site [chemical binding]; other site
700508007934	active site
700508007935	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508007936	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007937	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508007938	short chain dehydrogenase; Provisional; Region: PRK05993
700508007939	NAD(P) binding site [chemical binding]; other site
700508007940	active site
700508007941	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508007942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007943	WHG domain; Region: WHG; pfam13305
700508007944	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
700508007945	Putative esterase; Region: Esterase; pfam00756
700508007946	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
700508007947	putative transposase OrfB; Reviewed; Region: PHA02517
700508007948	Integrase core domain; Region: rve; pfam00665
700508007949	Integrase core domain; Region: rve_3; cl15866
700508007950	hypothetical protein; Provisional; Region: PRK06126
700508007951	hypothetical protein; Provisional; Region: PRK07236
700508007952	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508007953	SnoaL-like domain; Region: SnoaL_4; pfam13577
700508007954	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
700508007955	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007956	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
700508007957	putative active site [active]
700508007958	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
700508007959	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508007960	active site
700508007961	motif I; other site
700508007962	motif II; other site
700508007963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508007964	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
700508007965	PemK-like protein; Region: PemK; pfam02452
700508007966	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700508007967	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
700508007968	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508007969	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508007970	Transcriptional regulators [Transcription]; Region: MarR; COG1846
700508007971	MarR family; Region: MarR_2; pfam12802
700508007972	Amidohydrolase; Region: Amidohydro_2; pfam04909
700508007973	active site
700508007974	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700508007975	Int/Topo IB signature motif; other site
700508007976	DNA binding site [nucleotide binding]
700508007977	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
700508007978	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
700508007979	NADH(P)-binding; Region: NAD_binding_10; pfam13460
700508007980	NAD binding site [chemical binding]; other site
700508007981	substrate binding site [chemical binding]; other site
700508007982	putative active site [active]
700508007983	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508007984	MarR family; Region: MarR_2; pfam12802
700508007985	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508007986	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508007987	active site
700508007988	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508007989	Predicted transcriptional regulators [Transcription]; Region: COG1695
700508007990	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
700508007991	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
700508007992	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700508007993	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
700508007994	TIGR03086 family protein; Region: TIGR03086
700508007995	Predicted transcriptional regulator [Transcription]; Region: COG2378
700508007996	HTH domain; Region: HTH_11; pfam08279
700508007997	WYL domain; Region: WYL; pfam13280
700508007998	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
700508007999	dimer interface [polypeptide binding]; other site
700508008000	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508008001	metal binding site [ion binding]; metal-binding site
700508008002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008003	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700508008004	active site
700508008005	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508008006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508008007	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
700508008008	substrate binding pocket [chemical binding]; other site
700508008009	dimerization interface [polypeptide binding]; other site
700508008010	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008011	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008012	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
700508008013	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008014	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508008015	Transport protein; Region: actII; TIGR00833
700508008016	choline dehydrogenase; Validated; Region: PRK02106
700508008017	lycopene cyclase; Region: lycopene_cycl; TIGR01789
700508008018	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700508008019	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
700508008020	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508008021	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508008022	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508008023	active site
700508008024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008026	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
700508008027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508008028	putative substrate translocation pore; other site
700508008029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008031	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
700508008032	dimer interface [polypeptide binding]; other site
700508008033	substrate binding site [chemical binding]; other site
700508008034	ATP binding site [chemical binding]; other site
700508008035	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
700508008036	Transposase; Region: DDE_Tnp_ISL3; pfam01610
700508008037	Protein of unknown function (DUF3072); Region: DUF3072; pfam11272
700508008038	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
700508008039	putative hydrophobic ligand binding site [chemical binding]; other site
700508008040	Domain of unknown function (DUF303); Region: DUF303; pfam03629
700508008041	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
700508008042	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
700508008043	heme binding site [chemical binding]; other site
700508008044	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
700508008045	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
700508008046	metal binding site 2 [ion binding]; metal-binding site
700508008047	putative DNA binding helix; other site
700508008048	metal binding site 1 [ion binding]; metal-binding site
700508008049	dimer interface [polypeptide binding]; other site
700508008050	structural Zn2+ binding site [ion binding]; other site
700508008051	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
700508008052	dimanganese center [ion binding]; other site
700508008053	Phosphotransferase enzyme family; Region: APH; pfam01636
700508008054	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508008055	active site
700508008056	ATP binding site [chemical binding]; other site
700508008057	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
700508008058	hydrophobic ligand binding site; other site
700508008059	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700508008060	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700508008061	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700508008062	ligand binding site [chemical binding]; other site
700508008063	flexible hinge region; other site
700508008064	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700508008065	putative switch regulator; other site
700508008066	non-specific DNA interactions [nucleotide binding]; other site
700508008067	DNA binding site [nucleotide binding]
700508008068	sequence specific DNA binding site [nucleotide binding]; other site
700508008069	putative cAMP binding site [chemical binding]; other site
700508008070	Cutinase; Region: Cutinase; pfam01083
700508008071	Cutinase; Region: Cutinase; pfam01083
700508008072	Cutinase; Region: Cutinase; pfam01083
700508008073	Cutinase; Region: Cutinase; pfam01083
700508008074	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700508008075	RNA binding surface [nucleotide binding]; other site
700508008076	Uncharacterized conserved protein [Function unknown]; Region: COG2966
700508008077	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
700508008078	Uncharacterized conserved protein [Function unknown]; Region: COG3610
700508008079	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
700508008080	DNA-binding site [nucleotide binding]; DNA binding site
700508008081	RNA-binding motif; other site
700508008082	GXWXG protein; Region: GXWXG; pfam14231
700508008083	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
700508008084	NlpC/P60 family; Region: NLPC_P60; pfam00877
700508008085	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
700508008086	dimer interface [polypeptide binding]; other site
700508008087	catalytic triad [active]
700508008088	peroxidatic and resolving cysteines [active]
700508008089	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
700508008090	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508008091	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508008092	active site
700508008093	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508008094	Cytochrome P450; Region: p450; cl12078
700508008095	O-succinylbenzoate synthase; Provisional; Region: PRK02901
700508008096	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
700508008097	metal binding site [ion binding]; metal-binding site
700508008098	substrate binding pocket [chemical binding]; other site
700508008099	Uncharacterized conserved protein [Function unknown]; Region: COG3379
700508008100	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
700508008101	PglZ domain; Region: PglZ; pfam08665
700508008102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
700508008103	MOSC domain; Region: MOSC; pfam03473
700508008104	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
700508008105	active site
700508008106	catalytic triad [active]
700508008107	oxyanion hole [active]
700508008108	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700508008109	NlpC/P60 family; Region: NLPC_P60; cl17555
700508008110	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
700508008111	Transcriptional regulators [Transcription]; Region: FadR; COG2186
700508008112	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508008113	DNA-binding site [nucleotide binding]; DNA binding site
700508008114	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
700508008115	hypothetical protein; Validated; Region: PRK02101
700508008116	Predicted esterase [General function prediction only]; Region: COG0627
700508008117	S-formylglutathione hydrolase; Region: PLN02442
700508008118	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508008119	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
700508008120	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700508008121	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508008122	Coenzyme A binding pocket [chemical binding]; other site
700508008123	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508008124	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
700508008125	competence damage-inducible protein A; Provisional; Region: PRK00549
700508008126	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
700508008127	putative MPT binding site; other site
700508008128	Competence-damaged protein; Region: CinA; pfam02464
700508008129	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008130	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508008131	NAD(P) binding site [chemical binding]; other site
700508008132	active site
700508008133	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
700508008134	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
700508008135	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
700508008136	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
700508008137	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
700508008138	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008139	NAD(P) binding site [chemical binding]; other site
700508008140	active site
700508008141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008142	NAD(P) binding site [chemical binding]; other site
700508008143	active site
700508008144	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
700508008145	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
700508008146	Nitronate monooxygenase; Region: NMO; pfam03060
700508008147	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700508008148	FMN binding site [chemical binding]; other site
700508008149	substrate binding site [chemical binding]; other site
700508008150	putative catalytic residue [active]
700508008151	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008152	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008153	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
700508008154	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
700508008155	molybdopterin cofactor binding site; other site
700508008156	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
700508008157	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
700508008158	putative molybdopterin cofactor binding site; other site
700508008159	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508008160	Cytochrome P450; Region: p450; cl12078
700508008161	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508008162	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508008163	non-specific DNA binding site [nucleotide binding]; other site
700508008164	salt bridge; other site
700508008165	sequence-specific DNA binding site [nucleotide binding]; other site
700508008166	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508008167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508008168	active site
700508008169	phosphorylation site [posttranslational modification]
700508008170	intermolecular recognition site; other site
700508008171	dimerization interface [polypeptide binding]; other site
700508008172	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508008173	DNA binding site [nucleotide binding]
700508008174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508008175	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700508008176	dimerization interface [polypeptide binding]; other site
700508008177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508008178	dimer interface [polypeptide binding]; other site
700508008179	phosphorylation site [posttranslational modification]
700508008180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508008181	ATP binding site [chemical binding]; other site
700508008182	Mg2+ binding site [ion binding]; other site
700508008183	G-X-G motif; other site
700508008184	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
700508008185	Transcriptional regulators [Transcription]; Region: FadR; COG2186
700508008186	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508008187	DNA-binding site [nucleotide binding]; DNA binding site
700508008188	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
700508008189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
700508008190	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
700508008191	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700508008192	POT family; Region: PTR2; cl17359
700508008193	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
700508008194	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
700508008195	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
700508008196	tetramer interface [polypeptide binding]; other site
700508008197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508008198	catalytic residue [active]
700508008199	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700508008200	active site
700508008201	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508008202	Cytochrome P450; Region: p450; cl12078
700508008203	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
700508008204	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
700508008205	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700508008206	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
700508008207	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
700508008208	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508008209	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508008210	DNA binding site [nucleotide binding]
700508008211	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508008212	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
700508008213	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
700508008214	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
700508008215	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508008216	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508008217	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508008218	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508008219	Cytochrome P450; Region: p450; cl12078
700508008220	Uncharacterized conserved protein [Function unknown]; Region: COG2128
700508008221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508008222	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508008223	putative substrate translocation pore; other site
700508008224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508008225	putative substrate translocation pore; other site
700508008226	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
700508008227	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
700508008228	heme binding site [chemical binding]; other site
700508008229	ferroxidase pore; other site
700508008230	ferroxidase diiron center [ion binding]; other site
700508008231	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
700508008232	enoyl-CoA hydratase; Provisional; Region: PRK06688
700508008233	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508008234	substrate binding site [chemical binding]; other site
700508008235	oxyanion hole (OAH) forming residues; other site
700508008236	trimer interface [polypeptide binding]; other site
700508008237	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
700508008238	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508008239	CoenzymeA binding site [chemical binding]; other site
700508008240	subunit interaction site [polypeptide binding]; other site
700508008241	PHB binding site; other site
700508008242	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508008243	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508008244	DNA-binding site [nucleotide binding]; DNA binding site
700508008245	FCD domain; Region: FCD; pfam07729
700508008246	Amidase; Region: Amidase; cl11426
700508008247	Isochorismatase family; Region: Isochorismatase; pfam00857
700508008248	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
700508008249	catalytic triad [active]
700508008250	conserved cis-peptide bond; other site
700508008251	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
700508008252	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008253	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
700508008254	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
700508008255	TPR motif; other site
700508008256	TPR repeat; Region: TPR_11; pfam13414
700508008257	binding surface
700508008258	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
700508008259	nucleoside/Zn binding site; other site
700508008260	dimer interface [polypeptide binding]; other site
700508008261	catalytic motif [active]
700508008262	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
700508008263	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
700508008264	active site
700508008265	catalytic site [active]
700508008266	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
700508008267	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
700508008268	Mechanosensitive ion channel; Region: MS_channel; pfam00924
700508008269	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700508008270	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700508008271	ligand binding site [chemical binding]; other site
700508008272	flexible hinge region; other site
700508008273	Putative esterase; Region: Esterase; pfam00756
700508008274	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
700508008275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508008276	Walker A motif; other site
700508008277	ATP binding site [chemical binding]; other site
700508008278	Walker B motif; other site
700508008279	arginine finger; other site
700508008280	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
700508008281	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
700508008282	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
700508008283	OsmC-like protein; Region: OsmC; cl00767
700508008284	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
700508008285	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508008286	malate dehydrogenase; Provisional; Region: PRK05442
700508008287	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
700508008288	NAD(P) binding site [chemical binding]; other site
700508008289	LDH/MDH dimer interface [polypeptide binding]; other site
700508008290	substrate binding site [chemical binding]; other site
700508008291	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
700508008292	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508008293	active site
700508008294	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
700508008295	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508008296	NAD binding site [chemical binding]; other site
700508008297	catalytic residues [active]
700508008298	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508008299	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508008300	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508008301	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508008302	CAAX protease self-immunity; Region: Abi; pfam02517
700508008303	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508008304	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508008305	non-specific DNA binding site [nucleotide binding]; other site
700508008306	salt bridge; other site
700508008307	sequence-specific DNA binding site [nucleotide binding]; other site
700508008308	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
700508008309	active site
700508008310	Predicted membrane protein [Function unknown]; Region: COG2261
700508008311	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
700508008312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008313	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
700508008314	NAD(P) binding site [chemical binding]; other site
700508008315	active site
700508008316	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508008317	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
700508008318	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
700508008319	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508008320	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
700508008321	UreD urease accessory protein; Region: UreD; cl00530
700508008322	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700508008323	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
700508008324	urease subunit alpha; Reviewed; Region: ureC; PRK13206
700508008325	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
700508008326	subunit interactions [polypeptide binding]; other site
700508008327	active site
700508008328	flap region; other site
700508008329	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
700508008330	gamma-beta subunit interface [polypeptide binding]; other site
700508008331	alpha-beta subunit interface [polypeptide binding]; other site
700508008332	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
700508008333	alpha-gamma subunit interface [polypeptide binding]; other site
700508008334	beta-gamma subunit interface [polypeptide binding]; other site
700508008335	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508008336	CoenzymeA binding site [chemical binding]; other site
700508008337	subunit interaction site [polypeptide binding]; other site
700508008338	PHB binding site; other site
700508008339	Predicted transcriptional regulator [Transcription]; Region: COG3682
700508008340	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
700508008341	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700508008342	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
700508008343	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
700508008344	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
700508008345	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
700508008346	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
700508008347	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
700508008348	active site
700508008349	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
700508008350	Domain of unknown function DUF21; Region: DUF21; pfam01595
700508008351	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700508008352	Transporter associated domain; Region: CorC_HlyC; smart01091
700508008353	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
700508008354	Domain of unknown function DUF21; Region: DUF21; pfam01595
700508008355	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700508008356	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
700508008357	active site
700508008358	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
700508008359	metal ion-dependent adhesion site (MIDAS); other site
700508008360	Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080
700508008361	putative catalytic site [active]
700508008362	putative metal binding site [ion binding]; other site
700508008363	putative phosphate binding site [ion binding]; other site
700508008364	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508008365	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508008366	glycine dehydrogenase; Provisional; Region: PRK05367
700508008367	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
700508008368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508008369	tetramer interface [polypeptide binding]; other site
700508008370	catalytic residue [active]
700508008371	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
700508008372	tetramer interface [polypeptide binding]; other site
700508008373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508008374	catalytic residue [active]
700508008375	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
700508008376	DNA binding residues [nucleotide binding]
700508008377	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508008378	putative dimer interface [polypeptide binding]; other site
700508008379	Bifunctional nuclease; Region: DNase-RNase; pfam02577
700508008380	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
700508008381	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508008382	DNA binding residues [nucleotide binding]
700508008383	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700508008384	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700508008385	phosphopeptide binding site; other site
700508008386	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
700508008387	lipoyl attachment site [posttranslational modification]; other site
700508008388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
700508008389	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
700508008390	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
700508008391	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
700508008392	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
700508008393	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
700508008394	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
700508008395	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
700508008396	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
700508008397	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
700508008398	tricarballylate dehydrogenase; Validated; Region: PRK08274
700508008399	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
700508008400	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
700508008401	active site
700508008402	metal binding site [ion binding]; metal-binding site
700508008403	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008404	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008405	Domain of unknown function (DUF385); Region: DUF385; cl04387
700508008406	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
700508008407	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
700508008408	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
700508008409	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
700508008410	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
700508008411	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
700508008412	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508008413	substrate binding pocket [chemical binding]; other site
700508008414	catalytic triad [active]
700508008415	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
700508008416	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
700508008417	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
700508008418	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
700508008419	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508008420	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508008421	active site
700508008422	ATP binding site [chemical binding]; other site
700508008423	substrate binding site [chemical binding]; other site
700508008424	activation loop (A-loop); other site
700508008425	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
700508008426	nudix motif; other site
700508008427	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
700508008428	active site
700508008429	catalytic triad [active]
700508008430	oxyanion hole [active]
700508008431	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
700508008432	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700508008433	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
700508008434	active site
700508008435	FMN binding site [chemical binding]; other site
700508008436	substrate binding site [chemical binding]; other site
700508008437	homotetramer interface [polypeptide binding]; other site
700508008438	catalytic residue [active]
700508008439	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508008440	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508008441	GAF domain; Region: GAF; pfam01590
700508008442	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
700508008443	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508008444	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508008445	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
700508008446	NAD(P) binding site [chemical binding]; other site
700508008447	catalytic residues [active]
700508008448	benzoate transport; Region: 2A0115; TIGR00895
700508008449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508008450	putative substrate translocation pore; other site
700508008451	hypothetical protein; Provisional; Region: PRK07236
700508008452	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
700508008453	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
700508008454	acyl-CoA synthetase; Validated; Region: PRK07798
700508008455	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508008456	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
700508008457	acyl-activating enzyme (AAE) consensus motif; other site
700508008458	acyl-activating enzyme (AAE) consensus motif; other site
700508008459	putative AMP binding site [chemical binding]; other site
700508008460	putative active site [active]
700508008461	putative CoA binding site [chemical binding]; other site
700508008462	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700508008463	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
700508008464	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
700508008465	putative homodimer interface [polypeptide binding]; other site
700508008466	putative homotetramer interface [polypeptide binding]; other site
700508008467	putative allosteric switch controlling residues; other site
700508008468	putative metal binding site [ion binding]; other site
700508008469	putative homodimer-homodimer interface [polypeptide binding]; other site
700508008470	Predicted membrane protein [Function unknown]; Region: COG2149
700508008471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008472	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
700508008473	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508008474	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508008475	active site
700508008476	mce related protein; Region: MCE; pfam02470
700508008477	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508008478	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
700508008479	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
700508008480	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
700508008481	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
700508008482	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
700508008483	RNA binding site [nucleotide binding]; other site
700508008484	PknH-like extracellular domain; Region: PknH_C; pfam14032
700508008485	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
700508008486	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
700508008487	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
700508008488	Sulfate transporter family; Region: Sulfate_transp; pfam00916
700508008489	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
700508008490	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508008491	dimerization interface [polypeptide binding]; other site
700508008492	putative DNA binding site [nucleotide binding]; other site
700508008493	putative Zn2+ binding site [ion binding]; other site
700508008494	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
700508008495	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
700508008496	tetramer interface [polypeptide binding]; other site
700508008497	active site
700508008498	Mg2+/Mn2+ binding site [ion binding]; other site
700508008499	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
700508008500	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
700508008501	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
700508008502	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
700508008503	N-acetyl-D-glucosamine binding site [chemical binding]; other site
700508008504	catalytic residue [active]
700508008505	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
700508008506	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508008507	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
700508008508	Cobalt transport protein; Region: CbiQ; cl00463
700508008509	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700508008510	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700508008511	Walker A/P-loop; other site
700508008512	ATP binding site [chemical binding]; other site
700508008513	Q-loop/lid; other site
700508008514	ABC transporter signature motif; other site
700508008515	Walker B; other site
700508008516	D-loop; other site
700508008517	H-loop/switch region; other site
700508008518	BioY family; Region: BioY; pfam02632
700508008519	Integral membrane protein TerC family; Region: TerC; cl10468
700508008520	Transmembrane secretion effector; Region: MFS_3; pfam05977
700508008521	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
700508008522	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
700508008523	active site
700508008524	catalytic tetrad [active]
700508008525	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
700508008526	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
700508008527	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008528	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008529	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
700508008530	Sulfatase; Region: Sulfatase; pfam00884
700508008531	haloalkane dehalogenase; Provisional; Region: PRK00870
700508008532	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700508008533	Predicted transcriptional regulators [Transcription]; Region: COG1695
700508008534	Transcriptional regulator PadR-like family; Region: PadR; cl17335
700508008535	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
700508008536	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
700508008537	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700508008538	FMN binding site [chemical binding]; other site
700508008539	substrate binding site [chemical binding]; other site
700508008540	putative catalytic residue [active]
700508008541	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
700508008542	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508008543	Coenzyme A binding pocket [chemical binding]; other site
700508008544	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
700508008545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008546	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008547	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
700508008548	putative active site [active]
700508008549	putative substrate binding site [chemical binding]; other site
700508008550	ATP binding site [chemical binding]; other site
700508008551	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008552	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008553	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
700508008554	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508008555	subunit interaction site [polypeptide binding]; other site
700508008556	PHB binding site; other site
700508008557	CoenzymeA binding site [chemical binding]; other site
700508008558	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508008559	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
700508008560	CoenzymeA binding site [chemical binding]; other site
700508008561	subunit interaction site [polypeptide binding]; other site
700508008562	PHB binding site; other site
700508008563	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700508008564	hydrophobic ligand binding site; other site
700508008565	choline dehydrogenase; Validated; Region: PRK02106
700508008566	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
700508008567	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
700508008568	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
700508008569	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
700508008570	Subunit I/III interface [polypeptide binding]; other site
700508008571	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508008572	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508008573	active site
700508008574	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008576	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
700508008577	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508008578	dimer interface [polypeptide binding]; other site
700508008579	active site
700508008580	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508008581	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508008582	active site
700508008583	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508008584	Cytochrome P450; Region: p450; cl12078
700508008585	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
700508008586	Ferredoxin [Energy production and conversion]; Region: COG1146
700508008587	4Fe-4S binding domain; Region: Fer4; pfam00037
700508008588	ferredoxin-NADP+ reductase; Region: PLN02852
700508008589	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
700508008590	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
700508008591	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
700508008592	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
700508008593	NAD(P) binding site [chemical binding]; other site
700508008594	catalytic residues [active]
700508008595	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
700508008596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008597	NAD(P) binding site [chemical binding]; other site
700508008598	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008599	active site
700508008600	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508008601	Cytochrome P450; Region: p450; cl12078
700508008602	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508008603	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
700508008604	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
700508008605	acyl-activating enzyme (AAE) consensus motif; other site
700508008606	acyl-activating enzyme (AAE) consensus motif; other site
700508008607	putative AMP binding site [chemical binding]; other site
700508008608	putative active site [active]
700508008609	putative CoA binding site [chemical binding]; other site
700508008610	SCP-2 sterol transfer family; Region: SCP2; pfam02036
700508008611	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
700508008612	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508008613	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008614	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008615	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
700508008616	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
700508008617	Ecdysteroid kinase; Region: EcKinase; cl17738
700508008618	Phosphotransferase enzyme family; Region: APH; pfam01636
700508008619	Ecdysteroid kinase; Region: EcKinase; cl17738
700508008620	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
700508008621	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
700508008622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508008623	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508008624	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
700508008625	active site
700508008626	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508008627	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508008628	enoyl-CoA hydratase; Provisional; Region: PRK06688
700508008629	substrate binding site [chemical binding]; other site
700508008630	oxyanion hole (OAH) forming residues; other site
700508008631	trimer interface [polypeptide binding]; other site
700508008632	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
700508008633	putative active site [active]
700508008634	putative catalytic site [active]
700508008635	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508008636	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
700508008637	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508008638	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
700508008639	acyl-activating enzyme (AAE) consensus motif; other site
700508008640	putative AMP binding site [chemical binding]; other site
700508008641	putative active site [active]
700508008642	putative CoA binding site [chemical binding]; other site
700508008643	AMP-binding domain protein; Validated; Region: PRK08315
700508008644	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508008645	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
700508008646	acyl-activating enzyme (AAE) consensus motif; other site
700508008647	acyl-activating enzyme (AAE) consensus motif; other site
700508008648	putative AMP binding site [chemical binding]; other site
700508008649	putative active site [active]
700508008650	putative CoA binding site [chemical binding]; other site
700508008651	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
700508008652	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508008653	homodimer interface [polypeptide binding]; other site
700508008654	NAD binding site [chemical binding]; other site
700508008655	active site
700508008656	acetyl-CoA acetyltransferase; Validated; Region: PRK06157
700508008657	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508008658	active site
700508008659	3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425
700508008660	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
700508008661	active site
700508008662	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
700508008663	DUF35 OB-fold domain; Region: DUF35; pfam01796
700508008664	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
700508008665	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508008666	dimer interface [polypeptide binding]; other site
700508008667	active site
700508008668	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
700508008669	inter-subunit interface; other site
700508008670	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
700508008671	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
700508008672	iron-sulfur cluster [ion binding]; other site
700508008673	[2Fe-2S] cluster binding site [ion binding]; other site
700508008674	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
700508008675	putative alpha subunit interface [polypeptide binding]; other site
700508008676	putative active site [active]
700508008677	putative substrate binding site [chemical binding]; other site
700508008678	Fe binding site [ion binding]; other site
700508008679	enoyl-CoA hydratase; Provisional; Region: PRK06688
700508008680	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508008681	substrate binding site [chemical binding]; other site
700508008682	oxyanion hole (OAH) forming residues; other site
700508008683	trimer interface [polypeptide binding]; other site
700508008684	enoyl-CoA hydratase; Provisional; Region: PRK06688
700508008685	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508008686	substrate binding site [chemical binding]; other site
700508008687	oxyanion hole (OAH) forming residues; other site
700508008688	trimer interface [polypeptide binding]; other site
700508008689	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
700508008690	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700508008691	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508008692	substrate binding site [chemical binding]; other site
700508008693	oxyanion hole (OAH) forming residues; other site
700508008694	trimer interface [polypeptide binding]; other site
700508008695	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508008696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008697	NAD(P) binding site [chemical binding]; other site
700508008698	active site
700508008699	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508008700	classical (c) SDRs; Region: SDR_c; cd05233
700508008701	NAD(P) binding site [chemical binding]; other site
700508008702	active site
700508008703	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508008704	mce related protein; Region: MCE; pfam02470
700508008705	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508008706	mce related protein; Region: MCE; pfam02470
700508008707	RNA polymerase Rpb4; Region: RNA_pol_Rpb4; cl00638
700508008708	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508008709	mce related protein; Region: MCE; pfam02470
700508008710	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508008711	mce related protein; Region: MCE; pfam02470
700508008712	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508008713	mce related protein; Region: MCE; pfam02470
700508008714	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508008715	mce related protein; Region: MCE; pfam02470
700508008716	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508008717	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508008718	Permease; Region: Permease; pfam02405
700508008719	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508008720	Permease; Region: Permease; pfam02405
700508008721	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508008722	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508008723	active site 2 [active]
700508008724	active site 1 [active]
700508008725	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508008726	active site 2 [active]
700508008727	active site 1 [active]
700508008728	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008729	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008730	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
700508008731	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508008732	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508008733	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008734	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008735	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008736	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008737	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508008738	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508008739	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508008740	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
700508008741	YceI-like domain; Region: YceI; smart00867
700508008742	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508008743	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508008744	DNA-binding site [nucleotide binding]; DNA binding site
700508008745	FCD domain; Region: FCD; pfam07729
700508008746	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
700508008747	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
700508008748	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508008749	putative PBP binding loops; other site
700508008750	ABC-ATPase subunit interface; other site
700508008751	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
700508008752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508008753	dimer interface [polypeptide binding]; other site
700508008754	conserved gate region; other site
700508008755	putative PBP binding loops; other site
700508008756	ABC-ATPase subunit interface; other site
700508008757	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
700508008758	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508008759	Walker A/P-loop; other site
700508008760	ATP binding site [chemical binding]; other site
700508008761	Q-loop/lid; other site
700508008762	ABC transporter signature motif; other site
700508008763	Walker B; other site
700508008764	D-loop; other site
700508008765	H-loop/switch region; other site
700508008766	TOBE domain; Region: TOBE_2; pfam08402
700508008767	hypothetical protein; Provisional; Region: PRK06847
700508008768	Integrase core domain; Region: rve_3; cl15866
700508008769	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
700508008770	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508008771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508008772	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508008773	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
700508008774	tetramerization interface [polypeptide binding]; other site
700508008775	NAD(P) binding site [chemical binding]; other site
700508008776	catalytic residues [active]
700508008777	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
700508008778	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508008779	inhibitor-cofactor binding pocket; inhibition site
700508008780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508008781	catalytic residue [active]
700508008782	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508008783	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508008784	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
700508008785	putative dimerization interface [polypeptide binding]; other site
700508008786	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
700508008787	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508008788	inhibitor-cofactor binding pocket; inhibition site
700508008789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508008790	catalytic residue [active]
700508008791	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508008792	active site
700508008793	ATP binding site [chemical binding]; other site
700508008794	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
700508008795	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
700508008796	active site
700508008797	ATP binding site [chemical binding]; other site
700508008798	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
700508008799	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
700508008800	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508008801	inhibitor-cofactor binding pocket; inhibition site
700508008802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508008803	catalytic residue [active]
700508008804	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
700508008805	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
700508008806	NAD(P) binding site [chemical binding]; other site
700508008807	catalytic residues [active]
700508008808	amino acid transporter; Region: 2A0306; TIGR00909
700508008809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
700508008810	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
700508008811	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508008812	inhibitor-cofactor binding pocket; inhibition site
700508008813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508008814	catalytic residue [active]
700508008815	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508008816	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508008817	DNA-binding site [nucleotide binding]; DNA binding site
700508008818	FCD domain; Region: FCD; pfam07729
700508008819	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
700508008820	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
700508008821	active site
700508008822	multimer interface [polypeptide binding]; other site
700508008823	hypothetical protein; Provisional; Region: PRK06149
700508008824	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508008825	active site
700508008826	ATP binding site [chemical binding]; other site
700508008827	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508008828	inhibitor-cofactor binding pocket; inhibition site
700508008829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508008830	catalytic residue [active]
700508008831	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
700508008832	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
700508008833	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508008834	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
700508008835	active site
700508008836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508008837	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508008838	NAD(P) binding site [chemical binding]; other site
700508008839	active site
700508008840	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508008841	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508008842	DNA binding residues [nucleotide binding]
700508008843	dimerization interface [polypeptide binding]; other site
700508008844	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508008845	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508008846	DNA-binding site [nucleotide binding]; DNA binding site
700508008847	FCD domain; Region: FCD; pfam07729
700508008848	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700508008849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508008850	putative substrate translocation pore; other site
700508008851	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508008852	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508008853	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508008854	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508008855	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508008856	Transcriptional regulator [Transcription]; Region: IclR; COG1414
700508008857	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
700508008858	Bacterial transcriptional regulator; Region: IclR; pfam01614
700508008859	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
700508008860	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508008861	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508008862	classical (c) SDRs; Region: SDR_c; cd05233
700508008863	NAD(P) binding site [chemical binding]; other site
700508008864	active site
700508008865	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700508008866	Dienelactone hydrolase family; Region: DLH; pfam01738
700508008867	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
700508008868	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
700508008869	[2Fe-2S] cluster binding site [ion binding]; other site
700508008870	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
700508008871	putative alpha subunit interface [polypeptide binding]; other site
700508008872	putative active site [active]
700508008873	putative substrate binding site [chemical binding]; other site
700508008874	Fe binding site [ion binding]; other site
700508008875	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
700508008876	Serine hydrolase (FSH1); Region: FSH1; pfam03959
700508008877	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
700508008878	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
700508008879	[2Fe-2S] cluster binding site [ion binding]; other site
700508008880	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
700508008881	putative alpha subunit interface [polypeptide binding]; other site
700508008882	putative active site [active]
700508008883	putative substrate binding site [chemical binding]; other site
700508008884	Fe binding site [ion binding]; other site
700508008885	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
700508008886	inter-subunit interface; other site
700508008887	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508008888	Ligand Binding Site [chemical binding]; other site
700508008889	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
700508008890	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
700508008891	active site
700508008892	catalytic residues [active]
700508008893	metal binding site [ion binding]; metal-binding site
700508008894	DmpG-like communication domain; Region: DmpG_comm; pfam07836
700508008895	acetaldehyde dehydrogenase; Validated; Region: PRK08300
700508008896	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
700508008897	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
700508008898	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
700508008899	Amidohydrolase; Region: Amidohydro_2; pfam04909
700508008900	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
700508008901	[2Fe-2S] cluster binding site [ion binding]; other site
700508008902	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508008903	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508008904	active site
700508008905	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508008906	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508008907	active site
700508008908	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
700508008909	active site
700508008910	metal binding site [ion binding]; metal-binding site
700508008911	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508008912	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
700508008913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508008914	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508008915	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508008916	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508008917	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
700508008918	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
700508008919	putative NAD(P) binding site [chemical binding]; other site
700508008920	catalytic Zn binding site [ion binding]; other site
700508008921	structural Zn binding site [ion binding]; other site
700508008922	AMP-binding domain protein; Validated; Region: PRK08315
700508008923	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508008924	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
700508008925	acyl-activating enzyme (AAE) consensus motif; other site
700508008926	acyl-activating enzyme (AAE) consensus motif; other site
700508008927	putative AMP binding site [chemical binding]; other site
700508008928	putative active site [active]
700508008929	putative CoA binding site [chemical binding]; other site
700508008930	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508008931	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
700508008932	putative transposase OrfB; Reviewed; Region: PHA02517
700508008933	Integrase core domain; Region: rve; pfam00665
700508008934	Integrase core domain; Region: rve_3; cl15866
700508008935	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
700508008936	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
700508008937	Int/Topo IB signature motif; other site
700508008938	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
700508008939	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
700508008940	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700508008941	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700508008942	hypothetical protein; Provisional; Region: PRK10621
700508008943	GTP-binding protein Der; Reviewed; Region: PRK03003
700508008944	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
700508008945	G1 box; other site
700508008946	GTP/Mg2+ binding site [chemical binding]; other site
700508008947	Switch I region; other site
700508008948	G2 box; other site
700508008949	Switch II region; other site
700508008950	G3 box; other site
700508008951	G4 box; other site
700508008952	G5 box; other site
700508008953	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
700508008954	G1 box; other site
700508008955	GTP/Mg2+ binding site [chemical binding]; other site
700508008956	Switch I region; other site
700508008957	G2 box; other site
700508008958	G3 box; other site
700508008959	Switch II region; other site
700508008960	G4 box; other site
700508008961	G5 box; other site
700508008962	cytidylate kinase; Provisional; Region: cmk; PRK00023
700508008963	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
700508008964	CMP-binding site; other site
700508008965	The sites determining sugar specificity; other site
700508008966	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
700508008967	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700508008968	RNA binding surface [nucleotide binding]; other site
700508008969	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
700508008970	active site
700508008971	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
700508008972	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
700508008973	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
700508008974	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700508008975	P-loop; other site
700508008976	Magnesium ion binding site [ion binding]; other site
700508008977	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
700508008978	Magnesium ion binding site [ion binding]; other site
700508008979	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
700508008980	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700508008981	active site
700508008982	DNA binding site [nucleotide binding]
700508008983	Int/Topo IB signature motif; other site
700508008984	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
700508008985	dimer interface [polypeptide binding]; other site
700508008986	active site
700508008987	ADP-ribose binding site [chemical binding]; other site
700508008988	nudix motif; other site
700508008989	metal binding site [ion binding]; metal-binding site
700508008990	CTP synthetase; Validated; Region: pyrG; PRK05380
700508008991	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
700508008992	Catalytic site [active]
700508008993	active site
700508008994	UTP binding site [chemical binding]; other site
700508008995	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
700508008996	active site
700508008997	putative oxyanion hole; other site
700508008998	catalytic triad [active]
700508008999	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
700508009000	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
700508009001	Thiamine pyrophosphokinase; Region: TPK; cl08415
700508009002	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
700508009003	CGNR zinc finger; Region: zf-CGNR; pfam11706
700508009004	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508009005	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
700508009006	putative dimer interface [polypeptide binding]; other site
700508009007	ligand binding site [chemical binding]; other site
700508009008	Zn binding site [ion binding]; other site
700508009009	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
700508009010	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
700508009011	DNA repair protein RecN; Region: recN; TIGR00634
700508009012	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
700508009013	Walker A/P-loop; other site
700508009014	ATP binding site [chemical binding]; other site
700508009015	Q-loop/lid; other site
700508009016	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
700508009017	ABC transporter signature motif; other site
700508009018	Walker B; other site
700508009019	D-loop; other site
700508009020	H-loop/switch region; other site
700508009021	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
700508009022	ATP-NAD kinase; Region: NAD_kinase; pfam01513
700508009023	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
700508009024	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700508009025	RNA binding surface [nucleotide binding]; other site
700508009026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508009027	S-adenosylmethionine binding site [chemical binding]; other site
700508009028	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
700508009029	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
700508009030	active site
700508009031	HIGH motif; other site
700508009032	dimer interface [polypeptide binding]; other site
700508009033	KMSKS motif; other site
700508009034	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
700508009035	RNA binding surface [nucleotide binding]; other site
700508009036	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
700508009037	active site
700508009038	DNA binding site [nucleotide binding]
700508009039	Uncharacterized conserved protein [Function unknown]; Region: COG2835
700508009040	acyl-CoA synthetase; Validated; Region: PRK07868
700508009041	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
700508009042	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508009043	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508009044	active site
700508009045	CoA binding site [chemical binding]; other site
700508009046	AMP binding site [chemical binding]; other site
700508009047	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
700508009048	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700508009049	ABC transporter; Region: ABC_tran_2; pfam12848
700508009050	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700508009051	argininosuccinate lyase; Provisional; Region: PRK00855
700508009052	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
700508009053	active sites [active]
700508009054	tetramer interface [polypeptide binding]; other site
700508009055	argininosuccinate synthase; Provisional; Region: PRK13820
700508009056	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
700508009057	ANP binding site [chemical binding]; other site
700508009058	Substrate Binding Site II [chemical binding]; other site
700508009059	Substrate Binding Site I [chemical binding]; other site
700508009060	arginine repressor; Provisional; Region: PRK03341
700508009061	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
700508009062	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
700508009063	ornithine carbamoyltransferase; Provisional; Region: PRK00779
700508009064	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
700508009065	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
700508009066	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
700508009067	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508009068	inhibitor-cofactor binding pocket; inhibition site
700508009069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508009070	catalytic residue [active]
700508009071	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
700508009072	feedback inhibition sensing region; other site
700508009073	homohexameric interface [polypeptide binding]; other site
700508009074	nucleotide binding site [chemical binding]; other site
700508009075	N-acetyl-L-glutamate binding site [chemical binding]; other site
700508009076	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
700508009077	heterotetramer interface [polypeptide binding]; other site
700508009078	active site pocket [active]
700508009079	cleavage site
700508009080	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
700508009081	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
700508009082	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
700508009083	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
700508009084	putative tRNA-binding site [nucleotide binding]; other site
700508009085	B3/4 domain; Region: B3_4; pfam03483
700508009086	tRNA synthetase B5 domain; Region: B5; smart00874
700508009087	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
700508009088	dimer interface [polypeptide binding]; other site
700508009089	motif 1; other site
700508009090	motif 3; other site
700508009091	motif 2; other site
700508009092	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
700508009093	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
700508009094	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
700508009095	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
700508009096	dimer interface [polypeptide binding]; other site
700508009097	motif 1; other site
700508009098	active site
700508009099	motif 2; other site
700508009100	motif 3; other site
700508009101	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700508009102	cyclase homology domain; Region: CHD; cd07302
700508009103	nucleotidyl binding site; other site
700508009104	metal binding site [ion binding]; metal-binding site
700508009105	dimer interface [polypeptide binding]; other site
700508009106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
700508009107	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508009108	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508009109	active site
700508009110	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
700508009111	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
700508009112	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700508009113	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
700508009114	23S rRNA binding site [nucleotide binding]; other site
700508009115	L21 binding site [polypeptide binding]; other site
700508009116	L13 binding site [polypeptide binding]; other site
700508009117	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
700508009118	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
700508009119	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
700508009120	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
700508009121	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
700508009122	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
700508009123	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
700508009124	dimer interface [polypeptide binding]; other site
700508009125	putative anticodon binding site; other site
700508009126	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700508009127	motif 1; other site
700508009128	dimer interface [polypeptide binding]; other site
700508009129	active site
700508009130	motif 2; other site
700508009131	motif 3; other site
700508009132	Predicted esterase [General function prediction only]; Region: COG0627
700508009133	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
700508009134	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
700508009135	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
700508009136	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700508009137	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
700508009138	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
700508009139	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700508009140	Domain of unknown function (DUF427); Region: DUF427; pfam04248
700508009141	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508009142	Ligand Binding Site [chemical binding]; other site
700508009143	CsbD-like; Region: CsbD; pfam05532
700508009144	Asp23 family; Region: Asp23; pfam03780
700508009145	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700508009146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508009147	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508009148	DNA binding residues [nucleotide binding]
700508009149	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508009150	dimerization interface [polypeptide binding]; other site
700508009151	putative DNA binding site [nucleotide binding]; other site
700508009152	putative Zn2+ binding site [ion binding]; other site
700508009153	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
700508009154	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508009155	putative metal binding site [ion binding]; other site
700508009156	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
700508009157	arsenical-resistance protein; Region: acr3; TIGR00832
700508009158	Low molecular weight phosphatase family; Region: LMWPc; cl00105
700508009159	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
700508009160	active site
700508009161	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
700508009162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508009163	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508009164	putative substrate translocation pore; other site
700508009165	excinuclease ABC subunit B; Provisional; Region: PRK05298
700508009166	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508009167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508009168	nucleotide binding region [chemical binding]; other site
700508009169	ATP-binding site [chemical binding]; other site
700508009170	Ultra-violet resistance protein B; Region: UvrB; pfam12344
700508009171	UvrB/uvrC motif; Region: UVR; pfam02151
700508009172	Protein of unknown function (DUF402); Region: DUF402; cl00979
700508009173	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
700508009174	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
700508009175	CoA-binding site [chemical binding]; other site
700508009176	ATP-binding [chemical binding]; other site
700508009177	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
700508009178	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
700508009179	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
700508009180	RNA binding site [nucleotide binding]; other site
700508009181	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
700508009182	RNA binding site [nucleotide binding]; other site
700508009183	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
700508009184	RNA binding site [nucleotide binding]; other site
700508009185	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
700508009186	RNA binding site [nucleotide binding]; other site
700508009187	Protease prsW family; Region: PrsW-protease; pfam13367
700508009188	Uncharacterized conserved protein [Function unknown]; Region: COG2966
700508009189	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
700508009190	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
700508009191	DNA polymerase I; Provisional; Region: PRK05755
700508009192	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
700508009193	active site
700508009194	metal binding site 1 [ion binding]; metal-binding site
700508009195	putative 5' ssDNA interaction site; other site
700508009196	metal binding site 3; metal-binding site
700508009197	metal binding site 2 [ion binding]; metal-binding site
700508009198	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
700508009199	putative DNA binding site [nucleotide binding]; other site
700508009200	putative metal binding site [ion binding]; other site
700508009201	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
700508009202	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
700508009203	active site
700508009204	DNA binding site [nucleotide binding]
700508009205	catalytic site [active]
700508009206	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
700508009207	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508009208	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
700508009209	putative dimerization interface [polypeptide binding]; other site
700508009210	hypothetical protein; Provisional; Region: PRK07538
700508009211	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508009212	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
700508009213	lipid-transfer protein; Provisional; Region: PRK06059
700508009214	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508009215	active site
700508009216	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
700508009217	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
700508009218	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
700508009219	Walker A/P-loop; other site
700508009220	ATP binding site [chemical binding]; other site
700508009221	Q-loop/lid; other site
700508009222	ABC transporter signature motif; other site
700508009223	Walker B; other site
700508009224	D-loop; other site
700508009225	H-loop/switch region; other site
700508009226	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
700508009227	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
700508009228	Walker A/P-loop; other site
700508009229	ATP binding site [chemical binding]; other site
700508009230	Q-loop/lid; other site
700508009231	ABC transporter signature motif; other site
700508009232	Walker B; other site
700508009233	D-loop; other site
700508009234	H-loop/switch region; other site
700508009235	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
700508009236	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700508009237	TM-ABC transporter signature motif; other site
700508009238	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700508009239	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
700508009240	TM-ABC transporter signature motif; other site
700508009241	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700508009242	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
700508009243	dimerization interface [polypeptide binding]; other site
700508009244	ligand binding site [chemical binding]; other site
700508009245	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
700508009246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508009247	active site
700508009248	phosphorylation site [posttranslational modification]
700508009249	intermolecular recognition site; other site
700508009250	dimerization interface [polypeptide binding]; other site
700508009251	ANTAR domain; Region: ANTAR; pfam03861
700508009252	Predicted membrane protein [Function unknown]; Region: COG2860
700508009253	UPF0126 domain; Region: UPF0126; pfam03458
700508009254	UPF0126 domain; Region: UPF0126; pfam03458
700508009255	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
700508009256	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
700508009257	cyclase homology domain; Region: CHD; cd07302
700508009258	nucleotidyl binding site; other site
700508009259	metal binding site [ion binding]; metal-binding site
700508009260	dimer interface [polypeptide binding]; other site
700508009261	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
700508009262	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
700508009263	dimerization interface [polypeptide binding]; other site
700508009264	DPS ferroxidase diiron center [ion binding]; other site
700508009265	ion pore; other site
700508009266	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
700508009267	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508009268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508009269	active site
700508009270	phosphorylation site [posttranslational modification]
700508009271	intermolecular recognition site; other site
700508009272	dimerization interface [polypeptide binding]; other site
700508009273	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508009274	DNA binding residues [nucleotide binding]
700508009275	dimerization interface [polypeptide binding]; other site
700508009276	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700508009277	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700508009278	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700508009279	Walker A/P-loop; other site
700508009280	ATP binding site [chemical binding]; other site
700508009281	Q-loop/lid; other site
700508009282	ABC transporter signature motif; other site
700508009283	Walker B; other site
700508009284	D-loop; other site
700508009285	H-loop/switch region; other site
700508009286	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700508009287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508009288	dimer interface [polypeptide binding]; other site
700508009289	conserved gate region; other site
700508009290	putative PBP binding loops; other site
700508009291	ABC-ATPase subunit interface; other site
700508009292	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508009293	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508009294	substrate binding pocket [chemical binding]; other site
700508009295	membrane-bound complex binding site; other site
700508009296	hinge residues; other site
700508009297	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
700508009298	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
700508009299	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
700508009300	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
700508009301	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
700508009302	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
700508009303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508009304	Walker A/P-loop; other site
700508009305	ATP binding site [chemical binding]; other site
700508009306	Q-loop/lid; other site
700508009307	ABC transporter signature motif; other site
700508009308	Walker B; other site
700508009309	D-loop; other site
700508009310	H-loop/switch region; other site
700508009311	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
700508009312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508009313	Walker A/P-loop; other site
700508009314	ATP binding site [chemical binding]; other site
700508009315	Q-loop/lid; other site
700508009316	ABC transporter signature motif; other site
700508009317	Walker B; other site
700508009318	D-loop; other site
700508009319	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
700508009320	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
700508009321	active site
700508009322	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
700508009323	catalytic triad [active]
700508009324	dimer interface [polypeptide binding]; other site
700508009325	pyruvate kinase; Provisional; Region: PRK06247
700508009326	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
700508009327	domain interfaces; other site
700508009328	active site
700508009329	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
700508009330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508009331	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
700508009332	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
700508009333	active site
700508009334	dimer interface [polypeptide binding]; other site
700508009335	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
700508009336	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
700508009337	active site
700508009338	FMN binding site [chemical binding]; other site
700508009339	substrate binding site [chemical binding]; other site
700508009340	3Fe-4S cluster binding site [ion binding]; other site
700508009341	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
700508009342	domain interface; other site
700508009343	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
700508009344	TM2 domain; Region: TM2; pfam05154
700508009345	malate:quinone oxidoreductase; Validated; Region: PRK05257
700508009346	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
700508009347	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508009348	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508009349	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
700508009350	dimerization interface [polypeptide binding]; other site
700508009351	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
700508009352	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700508009353	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700508009354	Walker A/P-loop; other site
700508009355	ATP binding site [chemical binding]; other site
700508009356	Q-loop/lid; other site
700508009357	ABC transporter signature motif; other site
700508009358	Walker B; other site
700508009359	D-loop; other site
700508009360	H-loop/switch region; other site
700508009361	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
700508009362	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
700508009363	active site
700508009364	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
700508009365	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
700508009366	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
700508009367	putative NADP binding site [chemical binding]; other site
700508009368	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
700508009369	active site
700508009370	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
700508009371	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
700508009372	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
700508009373	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
700508009374	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508009375	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
700508009376	Ligand Binding Site [chemical binding]; other site
700508009377	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
700508009378	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
700508009379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
700508009380	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
700508009381	PAS domain; Region: PAS; smart00091
700508009382	putative active site [active]
700508009383	heme pocket [chemical binding]; other site
700508009384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508009385	ATP binding site [chemical binding]; other site
700508009386	Mg2+ binding site [ion binding]; other site
700508009387	G-X-G motif; other site
700508009388	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
700508009389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508009390	active site
700508009391	phosphorylation site [posttranslational modification]
700508009392	intermolecular recognition site; other site
700508009393	dimerization interface [polypeptide binding]; other site
700508009394	Transcriptional regulator; Region: CitT; pfam12431
700508009395	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
700508009396	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
700508009397	catalytic triad [active]
700508009398	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
700508009399	putative hydrophobic ligand binding site [chemical binding]; other site
700508009400	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508009401	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
700508009402	NAD(P) binding site [chemical binding]; other site
700508009403	active site
700508009404	DivIVA domain; Region: DivI1A_domain; TIGR03544
700508009405	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
700508009406	Predicted integral membrane protein [Function unknown]; Region: COG0762
700508009407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
700508009408	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
700508009409	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700508009410	catalytic residue [active]
700508009411	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
700508009412	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
700508009413	cell division protein FtsZ; Validated; Region: PRK09330
700508009414	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
700508009415	nucleotide binding site [chemical binding]; other site
700508009416	SulA interaction site; other site
700508009417	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
700508009418	Cell division protein FtsQ; Region: FtsQ; pfam03799
700508009419	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
700508009420	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700508009421	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700508009422	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700508009423	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
700508009424	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
700508009425	active site
700508009426	homodimer interface [polypeptide binding]; other site
700508009427	cell division protein FtsW; Region: ftsW; TIGR02614
700508009428	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
700508009429	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
700508009430	Mg++ binding site [ion binding]; other site
700508009431	putative catalytic motif [active]
700508009432	putative substrate binding site [chemical binding]; other site
700508009433	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700508009434	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700508009435	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700508009436	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
700508009437	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
700508009438	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700508009439	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700508009440	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
700508009441	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
700508009442	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700508009443	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
700508009444	MraW methylase family; Region: Methyltransf_5; cl17771
700508009445	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
700508009446	MraZ protein; Region: MraZ; pfam02381
700508009447	MraZ protein; Region: MraZ; pfam02381
700508009448	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
700508009449	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700508009450	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
700508009451	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
700508009452	substrate binding pocket [chemical binding]; other site
700508009453	chain length determination region; other site
700508009454	substrate-Mg2+ binding site; other site
700508009455	catalytic residues [active]
700508009456	aspartate-rich region 1; other site
700508009457	active site lid residues [active]
700508009458	aspartate-rich region 2; other site
700508009459	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
700508009460	Helix-turn-helix domain; Region: HTH_17; cl17695
700508009461	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508009462	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508009463	active site
700508009464	ATP binding site [chemical binding]; other site
700508009465	substrate binding site [chemical binding]; other site
700508009466	activation loop (A-loop); other site
700508009467	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
700508009468	ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040
700508009469	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
700508009470	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700508009471	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
700508009472	putative acyl-acceptor binding pocket; other site
700508009473	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
700508009474	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
700508009475	P loop; other site
700508009476	Nucleotide binding site [chemical binding]; other site
700508009477	DTAP/Switch II; other site
700508009478	Switch I; other site
700508009479	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
700508009480	putative hydrophobic ligand binding site [chemical binding]; other site
700508009481	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
700508009482	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
700508009483	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
700508009484	acyl-activating enzyme (AAE) consensus motif; other site
700508009485	putative AMP binding site [chemical binding]; other site
700508009486	putative active site [active]
700508009487	putative CoA binding site [chemical binding]; other site
700508009488	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700508009489	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508009490	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
700508009491	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
700508009492	NlpC/P60 family; Region: NLPC_P60; pfam00877
700508009493	hypothetical protein; Validated; Region: PRK07883
700508009494	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
700508009495	active site
700508009496	catalytic site [active]
700508009497	substrate binding site [chemical binding]; other site
700508009498	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
700508009499	GIY-YIG motif/motif A; other site
700508009500	active site
700508009501	catalytic site [active]
700508009502	putative DNA binding site [nucleotide binding]; other site
700508009503	metal binding site [ion binding]; metal-binding site
700508009504	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
700508009505	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
700508009506	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
700508009507	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
700508009508	Subunit I/III interface [polypeptide binding]; other site
700508009509	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
700508009510	Cytochrome c; Region: Cytochrom_C; pfam00034
700508009511	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
700508009512	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
700508009513	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
700508009514	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
700508009515	iron-sulfur cluster [ion binding]; other site
700508009516	[2Fe-2S] cluster binding site [ion binding]; other site
700508009517	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
700508009518	heme bH binding site [chemical binding]; other site
700508009519	Qi binding site; other site
700508009520	intrachain domain interface; other site
700508009521	heme bL binding site [chemical binding]; other site
700508009522	interchain domain interface [polypeptide binding]; other site
700508009523	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
700508009524	Qo binding site; other site
700508009525	Protein of unknown function (DUF664); Region: DUF664; pfam04978
700508009526	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
700508009527	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508009528	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
700508009529	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
700508009530	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
700508009531	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
700508009532	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
700508009533	active site
700508009534	dimer interface [polypeptide binding]; other site
700508009535	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
700508009536	Ligand Binding Site [chemical binding]; other site
700508009537	Molecular Tunnel; other site
700508009538	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
700508009539	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700508009540	substrate binding site [chemical binding]; other site
700508009541	ATP binding site [chemical binding]; other site
700508009542	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
700508009543	Glycerate kinase family; Region: Gly_kinase; cl00841
700508009544	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
700508009545	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
700508009546	homotrimer interface [polypeptide binding]; other site
700508009547	Walker A motif; other site
700508009548	GTP binding site [chemical binding]; other site
700508009549	Walker B motif; other site
700508009550	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
700508009551	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
700508009552	putative dimer interface [polypeptide binding]; other site
700508009553	active site pocket [active]
700508009554	putative cataytic base [active]
700508009555	cobalamin synthase; Reviewed; Region: cobS; PRK00235
700508009556	Uncharacterized conserved protein [Function unknown]; Region: COG0397
700508009557	hypothetical protein; Validated; Region: PRK00029
700508009558	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
700508009559	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
700508009560	homodimer interface [polypeptide binding]; other site
700508009561	substrate-cofactor binding pocket; other site
700508009562	catalytic residue [active]
700508009563	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
700508009564	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
700508009565	cyclase homology domain; Region: CHD; cd07302
700508009566	nucleotidyl binding site; other site
700508009567	metal binding site [ion binding]; metal-binding site
700508009568	dimer interface [polypeptide binding]; other site
700508009569	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700508009570	multifunctional aminopeptidase A; Provisional; Region: PRK00913
700508009571	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
700508009572	interface (dimer of trimers) [polypeptide binding]; other site
700508009573	Substrate-binding/catalytic site; other site
700508009574	Zn-binding sites [ion binding]; other site
700508009575	short chain dehydrogenase; Validated; Region: PRK05855
700508009576	classical (c) SDRs; Region: SDR_c; cd05233
700508009577	NAD(P) binding site [chemical binding]; other site
700508009578	active site
700508009579	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700508009580	E3 interaction surface; other site
700508009581	lipoyl attachment site [posttranslational modification]; other site
700508009582	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700508009583	E3 interaction surface; other site
700508009584	lipoyl attachment site [posttranslational modification]; other site
700508009585	e3 binding domain; Region: E3_binding; pfam02817
700508009586	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
700508009587	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
700508009588	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
700508009589	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
700508009590	putative NAD(P) binding site [chemical binding]; other site
700508009591	putative active site [active]
700508009592	lipoate-protein ligase B; Provisional; Region: PRK14345
700508009593	lipoyl synthase; Provisional; Region: PRK05481
700508009594	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508009595	FeS/SAM binding site; other site
700508009596	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
700508009597	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
700508009598	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
700508009599	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
700508009600	active site
700508009601	RDD family; Region: RDD; pfam06271
700508009602	glutamine synthetase, type I; Region: GlnA; TIGR00653
700508009603	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
700508009604	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700508009605	Predicted membrane protein [Function unknown]; Region: COG2259
700508009606	Predicted membrane protein [Function unknown]; Region: COG2259
700508009607	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508009608	CoenzymeA binding site [chemical binding]; other site
700508009609	subunit interaction site [polypeptide binding]; other site
700508009610	PHB binding site; other site
700508009611	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
700508009612	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
700508009613	metal binding triad; other site
700508009614	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
700508009615	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
700508009616	metal binding triad; other site
700508009617	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
700508009618	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
700508009619	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
700508009620	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700508009621	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
700508009622	TAP-like protein; Region: Abhydrolase_4; pfam08386
700508009623	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
700508009624	TAP-like protein; Region: Abhydrolase_4; pfam08386
700508009625	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508009626	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
700508009627	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
700508009628	oligomerization interface [polypeptide binding]; other site
700508009629	active site
700508009630	metal binding site [ion binding]; metal-binding site
700508009631	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700508009632	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508009633	substrate binding site [chemical binding]; other site
700508009634	oxyanion hole (OAH) forming residues; other site
700508009635	trimer interface [polypeptide binding]; other site
700508009636	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
700508009637	putative active site; other site
700508009638	putative metal binding residues [ion binding]; other site
700508009639	signature motif; other site
700508009640	putative triphosphate binding site [ion binding]; other site
700508009641	CHAD domain; Region: CHAD; pfam05235
700508009642	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508009643	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508009644	active site
700508009645	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
700508009646	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508009647	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700508009648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508009649	S-adenosylmethionine binding site [chemical binding]; other site
700508009650	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508009651	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508009652	non-specific DNA binding site [nucleotide binding]; other site
700508009653	salt bridge; other site
700508009654	sequence-specific DNA binding site [nucleotide binding]; other site
700508009655	Cupin domain; Region: Cupin_2; pfam07883
700508009656	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
700508009657	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
700508009658	RNA/DNA hybrid binding site [nucleotide binding]; other site
700508009659	active site
700508009660	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508009661	catalytic core [active]
700508009662	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
700508009663	Putative zinc ribbon domain; Region: DUF164; pfam02591
700508009664	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
700508009665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
700508009666	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
700508009667	hypothetical protein; Provisional; Region: PRK07908
700508009668	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508009669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508009670	homodimer interface [polypeptide binding]; other site
700508009671	catalytic residue [active]
700508009672	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
700508009673	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508009674	motif II; other site
700508009675	Low molecular weight phosphatase family; Region: LMWPc; cd00115
700508009676	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
700508009677	active site
700508009678	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
700508009679	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
700508009680	SOUL heme-binding protein; Region: SOUL; pfam04832
700508009681	MspA; Region: MspA; pfam09203
700508009682	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
700508009683	putative metal binding residues [ion binding]; other site
700508009684	signature motif; other site
700508009685	dimer interface [polypeptide binding]; other site
700508009686	active site
700508009687	polyP binding site; other site
700508009688	substrate binding site [chemical binding]; other site
700508009689	acceptor-phosphate pocket; other site
700508009690	Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337
700508009691	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
700508009692	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
700508009693	dimer interface [polypeptide binding]; other site
700508009694	catalytic triad [active]
700508009695	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
700508009696	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
700508009697	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
700508009698	dimer interface [polypeptide binding]; other site
700508009699	TPP-binding site [chemical binding]; other site
700508009700	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
700508009701	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508009702	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
700508009703	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
700508009704	acyl carrier protein; Provisional; Region: acpP; PRK00982
700508009705	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
700508009706	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
700508009707	dimer interface [polypeptide binding]; other site
700508009708	active site
700508009709	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
700508009710	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
700508009711	dimer interface [polypeptide binding]; other site
700508009712	active site
700508009713	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
700508009714	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
700508009715	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
700508009716	short chain dehydrogenase; Provisional; Region: PRK12744
700508009717	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
700508009718	NADP binding site [chemical binding]; other site
700508009719	homodimer interface [polypeptide binding]; other site
700508009720	active site
700508009721	substrate binding site [chemical binding]; other site
700508009722	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508009723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508009724	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
700508009725	dimerization interface [polypeptide binding]; other site
700508009726	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
700508009727	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508009728	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508009729	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700508009730	FAD binding domain; Region: FAD_binding_4; pfam01565
700508009731	diacylglycerol kinase; Reviewed; Region: PRK11914
700508009732	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
700508009733	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
700508009734	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
700508009735	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508009736	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508009737	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
700508009738	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
700508009739	NAD binding site [chemical binding]; other site
700508009740	catalytic Zn binding site [ion binding]; other site
700508009741	substrate binding site [chemical binding]; other site
700508009742	structural Zn binding site [ion binding]; other site
700508009743	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508009744	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
700508009745	Short C-terminal domain; Region: SHOCT; pfam09851
700508009746	SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109
700508009747	hypothetical protein; Validated; Region: PRK07586
700508009748	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
700508009749	PYR/PP interface [polypeptide binding]; other site
700508009750	dimer interface [polypeptide binding]; other site
700508009751	TPP binding site [chemical binding]; other site
700508009752	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
700508009753	TPP-binding site [chemical binding]; other site
700508009754	dimer interface [polypeptide binding]; other site
700508009755	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
700508009756	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
700508009757	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
700508009758	classical (c) SDRs; Region: SDR_c; cd05233
700508009759	NAD(P) binding site [chemical binding]; other site
700508009760	active site
700508009761	AAA domain; Region: AAA_30; pfam13604
700508009762	PIF1-like helicase; Region: PIF1; pfam05970
700508009763	Family description; Region: UvrD_C_2; pfam13538
700508009764	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
700508009765	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
700508009766	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
700508009767	Uncharacterized conserved protein [Function unknown]; Region: COG0398
700508009768	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
700508009769	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
700508009770	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
700508009771	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
700508009772	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
700508009773	structural tetrad; other site
700508009774	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508009775	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508009776	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
700508009777	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508009778	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508009779	metal binding site [ion binding]; metal-binding site
700508009780	active site
700508009781	I-site; other site
700508009782	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508009783	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508009784	active site
700508009785	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
700508009786	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508009787	NAD(P) binding site [chemical binding]; other site
700508009788	active site
700508009789	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508009790	Cytochrome P450; Region: p450; cl12078
700508009791	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
700508009792	Flavodoxin; Region: Flavodoxin_1; pfam00258
700508009793	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
700508009794	FAD binding pocket [chemical binding]; other site
700508009795	FAD binding motif [chemical binding]; other site
700508009796	catalytic residues [active]
700508009797	NAD binding pocket [chemical binding]; other site
700508009798	phosphate binding motif [ion binding]; other site
700508009799	beta-alpha-beta structure motif; other site
700508009800	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
700508009801	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
700508009802	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
700508009803	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
700508009804	Transposase; Region: HTH_Tnp_1; cl17663
700508009805	putative transposase OrfB; Reviewed; Region: PHA02517
700508009806	Integrase core domain; Region: rve; pfam00665
700508009807	Integrase core domain; Region: rve_2; pfam13333
700508009808	Helix-turn-helix domain; Region: HTH_28; pfam13518
700508009809	Winged helix-turn helix; Region: HTH_29; pfam13551
700508009810	Transcriptional regulators [Transcription]; Region: FadR; COG2186
700508009811	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508009812	DNA-binding site [nucleotide binding]; DNA binding site
700508009813	FCD domain; Region: FCD; pfam07729
700508009814	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508009815	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508009816	substrate binding pocket [chemical binding]; other site
700508009817	membrane-bound complex binding site; other site
700508009818	hinge residues; other site
700508009819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508009820	dimer interface [polypeptide binding]; other site
700508009821	conserved gate region; other site
700508009822	putative PBP binding loops; other site
700508009823	ABC-ATPase subunit interface; other site
700508009824	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700508009825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508009826	dimer interface [polypeptide binding]; other site
700508009827	conserved gate region; other site
700508009828	putative PBP binding loops; other site
700508009829	ABC-ATPase subunit interface; other site
700508009830	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700508009831	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700508009832	Walker A/P-loop; other site
700508009833	ATP binding site [chemical binding]; other site
700508009834	Q-loop/lid; other site
700508009835	ABC transporter signature motif; other site
700508009836	Walker B; other site
700508009837	D-loop; other site
700508009838	H-loop/switch region; other site
700508009839	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
700508009840	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508009841	active site
700508009842	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508009843	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
700508009844	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
700508009845	active site pocket [active]
700508009846	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
700508009847	active site
700508009848	intersubunit interface [polypeptide binding]; other site
700508009849	catalytic residue [active]
700508009850	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700508009851	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
700508009852	substrate binding site [chemical binding]; other site
700508009853	ATP binding site [chemical binding]; other site
700508009854	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
700508009855	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
700508009856	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
700508009857	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
700508009858	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
700508009859	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508009860	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508009861	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508009862	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
700508009863	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
700508009864	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700508009865	Walker A/P-loop; other site
700508009866	ATP binding site [chemical binding]; other site
700508009867	Q-loop/lid; other site
700508009868	ABC transporter signature motif; other site
700508009869	Walker B; other site
700508009870	D-loop; other site
700508009871	H-loop/switch region; other site
700508009872	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700508009873	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
700508009874	Walker A/P-loop; other site
700508009875	ATP binding site [chemical binding]; other site
700508009876	Q-loop/lid; other site
700508009877	ABC transporter signature motif; other site
700508009878	Walker B; other site
700508009879	D-loop; other site
700508009880	H-loop/switch region; other site
700508009881	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508009882	MarR family; Region: MarR; pfam01047
700508009883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508009884	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508009885	putative substrate translocation pore; other site
700508009886	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
700508009887	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508009888	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508009889	active site
700508009890	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
700508009891	DNA primase; Validated; Region: dnaG; PRK05667
700508009892	CHC2 zinc finger; Region: zf-CHC2; cl17510
700508009893	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
700508009894	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
700508009895	active site
700508009896	metal binding site [ion binding]; metal-binding site
700508009897	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
700508009898	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
700508009899	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
700508009900	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
700508009901	Zn2+ binding site [ion binding]; other site
700508009902	Mg2+ binding site [ion binding]; other site
700508009903	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
700508009904	Repair protein; Region: Repair_PSII; pfam04536
700508009905	glycyl-tRNA synthetase; Provisional; Region: PRK04173
700508009906	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700508009907	motif 1; other site
700508009908	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
700508009909	active site
700508009910	motif 2; other site
700508009911	motif 3; other site
700508009912	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
700508009913	anticodon binding site; other site
700508009914	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508009915	dimerization interface [polypeptide binding]; other site
700508009916	putative Zn2+ binding site [ion binding]; other site
700508009917	putative DNA binding site [nucleotide binding]; other site
700508009918	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
700508009919	metal binding site 2 [ion binding]; metal-binding site
700508009920	putative DNA binding helix; other site
700508009921	metal binding site 1 [ion binding]; metal-binding site
700508009922	dimer interface [polypeptide binding]; other site
700508009923	structural Zn2+ binding site [ion binding]; other site
700508009924	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
700508009925	nudix motif; other site
700508009926	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
700508009927	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
700508009928	catalytic residue [active]
700508009929	putative FPP diphosphate  binding site; other site
700508009930	putative FPP binding hydrophobic cleft; other site
700508009931	dimer interface [polypeptide binding]; other site
700508009932	putative IPP diphosphate binding site; other site
700508009933	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
700508009934	Recombination protein O N terminal; Region: RecO_N; pfam11967
700508009935	Recombination protein O C terminal; Region: RecO_C; pfam02565
700508009936	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
700508009937	GTPase Era; Reviewed; Region: era; PRK00089
700508009938	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
700508009939	G1 box; other site
700508009940	GTP/Mg2+ binding site [chemical binding]; other site
700508009941	Switch I region; other site
700508009942	G2 box; other site
700508009943	Switch II region; other site
700508009944	G3 box; other site
700508009945	G4 box; other site
700508009946	G5 box; other site
700508009947	KH domain; Region: KH_2; pfam07650
700508009948	Domain of unknown function DUF21; Region: DUF21; pfam01595
700508009949	FOG: CBS domain [General function prediction only]; Region: COG0517
700508009950	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
700508009951	Transporter associated domain; Region: CorC_HlyC; smart01091
700508009952	metal-binding heat shock protein; Provisional; Region: PRK00016
700508009953	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
700508009954	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
700508009955	PhoH-like protein; Region: PhoH; pfam02562
700508009956	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
700508009957	chaperone protein DnaJ; Provisional; Region: PRK14278
700508009958	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
700508009959	HSP70 interaction site [polypeptide binding]; other site
700508009960	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
700508009961	Zn binding sites [ion binding]; other site
700508009962	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
700508009963	dimer interface [polypeptide binding]; other site
700508009964	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
700508009965	HTH domain; Region: HTH_11; cl17392
700508009966	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
700508009967	MbtH-like protein; Region: MbtH; pfam03621
700508009968	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
700508009969	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508009970	Condensation domain; Region: Condensation; pfam00668
700508009971	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508009972	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508009973	acyl-activating enzyme (AAE) consensus motif; other site
700508009974	AMP binding site [chemical binding]; other site
700508009975	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508009976	Condensation domain; Region: Condensation; pfam00668
700508009977	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
700508009978	Condensation domain; Region: Condensation; pfam00668
700508009979	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508009980	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700508009981	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508009982	acyl-activating enzyme (AAE) consensus motif; other site
700508009983	AMP binding site [chemical binding]; other site
700508009984	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508009985	Condensation domain; Region: Condensation; pfam00668
700508009986	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508009987	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700508009988	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508009989	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508009990	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
700508009991	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
700508009992	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
700508009993	NADP binding site [chemical binding]; other site
700508009994	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
700508009995	active site
700508009996	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
700508009997	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
700508009998	active site
700508009999	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
700508010000	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
700508010001	Condensation domain; Region: Condensation; pfam00668
700508010002	Nonribosomal peptide synthase; Region: NRPS; pfam08415
700508010003	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
700508010004	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
700508010005	acyl-activating enzyme (AAE) consensus motif; other site
700508010006	AMP binding site [chemical binding]; other site
700508010007	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
700508010008	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
700508010009	acyl-activating enzyme (AAE) consensus motif; other site
700508010010	active site
700508010011	AMP binding site [chemical binding]; other site
700508010012	substrate binding site [chemical binding]; other site
700508010013	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
700508010014	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
700508010015	active site
700508010016	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
700508010017	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
700508010018	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
700508010019	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
700508010020	NADP binding site [chemical binding]; other site
700508010021	active site
700508010022	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
700508010023	coproporphyrinogen III oxidase; Validated; Region: PRK05628
700508010024	HemN C-terminal domain; Region: HemN_C; pfam06969
700508010025	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
700508010026	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
700508010027	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
700508010028	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
700508010029	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
700508010030	Active Sites [active]
700508010031	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
700508010032	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
700508010033	putative active site [active]
700508010034	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
700508010035	putative active site [active]
700508010036	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010037	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
700508010038	Amidase; Region: Amidase; cl11426
700508010039	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
700508010040	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
700508010041	Walker A/P-loop; other site
700508010042	ATP binding site [chemical binding]; other site
700508010043	Q-loop/lid; other site
700508010044	ABC transporter signature motif; other site
700508010045	Walker B; other site
700508010046	D-loop; other site
700508010047	H-loop/switch region; other site
700508010048	TOBE domain; Region: TOBE; pfam03459
700508010049	sulfate transport protein; Provisional; Region: cysT; CHL00187
700508010050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508010051	dimer interface [polypeptide binding]; other site
700508010052	conserved gate region; other site
700508010053	putative PBP binding loops; other site
700508010054	ABC-ATPase subunit interface; other site
700508010055	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
700508010056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508010057	dimer interface [polypeptide binding]; other site
700508010058	conserved gate region; other site
700508010059	putative PBP binding loops; other site
700508010060	ABC-ATPase subunit interface; other site
700508010061	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
700508010062	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
700508010063	hypothetical protein; Provisional; Region: PRK06185
700508010064	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
700508010065	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
700508010066	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
700508010067	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
700508010068	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508010069	catalytic residue [active]
700508010070	hypothetical protein; Provisional; Region: PRK01346
700508010071	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
700508010072	Coenzyme A binding pocket [chemical binding]; other site
700508010073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508010074	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700508010075	S-adenosylmethionine binding site [chemical binding]; other site
700508010076	PknH-like extracellular domain; Region: PknH_C; pfam14032
700508010077	GTP-binding protein LepA; Provisional; Region: PRK05433
700508010078	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
700508010079	putative GEF interaction site [polypeptide binding]; other site
700508010080	Switch I region; other site
700508010081	G2 box; other site
700508010082	G3 box; other site
700508010083	Switch II region; other site
700508010084	GTP/Mg2+ binding site [chemical binding]; other site
700508010085	G4 box; other site
700508010086	G5 box; other site
700508010087	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
700508010088	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
700508010089	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
700508010090	PemK-like protein; Region: PemK; pfam02452
700508010091	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
700508010092	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
700508010093	active site
700508010094	dimer interface [polypeptide binding]; other site
700508010095	non-prolyl cis peptide bond; other site
700508010096	insertion regions; other site
700508010097	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
700508010098	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
700508010099	Walker A/P-loop; other site
700508010100	ATP binding site [chemical binding]; other site
700508010101	Q-loop/lid; other site
700508010102	ABC transporter signature motif; other site
700508010103	Walker B; other site
700508010104	D-loop; other site
700508010105	H-loop/switch region; other site
700508010106	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
700508010107	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
700508010108	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
700508010109	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
700508010110	active site
700508010111	non-prolyl cis peptide bond; other site
700508010112	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
700508010113	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
700508010114	Walker A/P-loop; other site
700508010115	ATP binding site [chemical binding]; other site
700508010116	Q-loop/lid; other site
700508010117	ABC transporter signature motif; other site
700508010118	Walker B; other site
700508010119	D-loop; other site
700508010120	H-loop/switch region; other site
700508010121	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
700508010122	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
700508010123	ABC-ATPase subunit  interface; other site
700508010124	dimer interface [polypeptide binding]; other site
700508010125	putative PBP binding regions; other site
700508010126	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
700508010127	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
700508010128	putative ligand binding residues [chemical binding]; other site
700508010129	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
700508010130	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
700508010131	putative ligand binding residues [chemical binding]; other site
700508010132	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
700508010133	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
700508010134	FOG: CBS domain [General function prediction only]; Region: COG0517
700508010135	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
700508010136	ribonuclease Z; Reviewed; Region: PRK00055
700508010137	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
700508010138	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
700508010139	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
700508010140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
700508010141	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
700508010142	Uncharacterized conserved protein [Function unknown]; Region: COG2308
700508010143	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
700508010144	hypothetical protein; Reviewed; Region: PRK07914
700508010145	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
700508010146	Competence protein; Region: Competence; pfam03772
700508010147	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
700508010148	Helix-hairpin-helix motif; Region: HHH; pfam00633
700508010149	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
700508010150	putative dimer interface [polypeptide binding]; other site
700508010151	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508010152	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508010153	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010154	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508010155	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
700508010156	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742
700508010157	EDD domain protein, DegV family; Region: DegV; TIGR00762
700508010158	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
700508010159	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
700508010160	active site
700508010161	catalytic triad [active]
700508010162	oxyanion hole [active]
700508010163	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508010164	catalytic core [active]
700508010165	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
700508010166	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
700508010167	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
700508010168	active site
700508010169	(T/H)XGH motif; other site
700508010170	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
700508010171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508010172	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700508010173	Walker A motif; other site
700508010174	ATP binding site [chemical binding]; other site
700508010175	Walker B motif; other site
700508010176	arginine finger; other site
700508010177	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
700508010178	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
700508010179	putative catalytic cysteine [active]
700508010180	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
700508010181	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700508010182	substrate binding site [chemical binding]; other site
700508010183	dimer interface [polypeptide binding]; other site
700508010184	ATP binding site [chemical binding]; other site
700508010185	NAD synthetase; Reviewed; Region: nadE; PRK02628
700508010186	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
700508010187	multimer interface [polypeptide binding]; other site
700508010188	active site
700508010189	catalytic triad [active]
700508010190	protein interface 1 [polypeptide binding]; other site
700508010191	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
700508010192	homodimer interface [polypeptide binding]; other site
700508010193	NAD binding pocket [chemical binding]; other site
700508010194	ATP binding pocket [chemical binding]; other site
700508010195	Mg binding site [ion binding]; other site
700508010196	active-site loop [active]
700508010197	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508010198	active site
700508010199	ATP binding site [chemical binding]; other site
700508010200	NAD-dependent deacetylase; Provisional; Region: PRK00481
700508010201	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
700508010202	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508010203	Cytochrome P450; Region: p450; cl12078
700508010204	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508010205	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010206	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
700508010207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508010208	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
700508010209	active site
700508010210	catalytic triad [active]
700508010211	dimer interface [polypeptide binding]; other site
700508010212	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
700508010213	gamma-glutamyl kinase; Provisional; Region: PRK05429
700508010214	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
700508010215	nucleotide binding site [chemical binding]; other site
700508010216	homotetrameric interface [polypeptide binding]; other site
700508010217	putative phosphate binding site [ion binding]; other site
700508010218	putative allosteric binding site; other site
700508010219	PUA domain; Region: PUA; pfam01472
700508010220	GTPase CgtA; Reviewed; Region: obgE; PRK12296
700508010221	GTP1/OBG; Region: GTP1_OBG; pfam01018
700508010222	Obg GTPase; Region: Obg; cd01898
700508010223	G1 box; other site
700508010224	GTP/Mg2+ binding site [chemical binding]; other site
700508010225	Switch I region; other site
700508010226	G2 box; other site
700508010227	G3 box; other site
700508010228	Switch II region; other site
700508010229	G4 box; other site
700508010230	G5 box; other site
700508010231	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
700508010232	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
700508010233	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
700508010234	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
700508010235	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
700508010236	homodimer interface [polypeptide binding]; other site
700508010237	oligonucleotide binding site [chemical binding]; other site
700508010238	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
700508010239	active site
700508010240	multimer interface [polypeptide binding]; other site
700508010241	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
700508010242	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
700508010243	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
700508010244	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
700508010245	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
700508010246	active site
700508010247	HIGH motif; other site
700508010248	nucleotide binding site [chemical binding]; other site
700508010249	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
700508010250	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
700508010251	active site
700508010252	KMSKS motif; other site
700508010253	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
700508010254	tRNA binding surface [nucleotide binding]; other site
700508010255	anticodon binding site; other site
700508010256	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
700508010257	Uncharacterized conserved protein [Function unknown]; Region: COG3268
700508010258	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700508010259	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508010260	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
700508010261	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
700508010262	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
700508010263	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
700508010264	FMN-binding pocket [chemical binding]; other site
700508010265	flavin binding motif; other site
700508010266	phosphate binding motif [ion binding]; other site
700508010267	beta-alpha-beta structure motif; other site
700508010268	NAD binding pocket [chemical binding]; other site
700508010269	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508010270	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
700508010271	catalytic loop [active]
700508010272	iron binding site [ion binding]; other site
700508010273	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
700508010274	hypothetical protein; Provisional; Region: PRK06753
700508010275	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
700508010276	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
700508010277	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
700508010278	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
700508010279	GTP binding site; other site
700508010280	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
700508010281	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
700508010282	TPP-binding site [chemical binding]; other site
700508010283	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
700508010284	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
700508010285	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
700508010286	dimer interface [polypeptide binding]; other site
700508010287	PYR/PP interface [polypeptide binding]; other site
700508010288	TPP binding site [chemical binding]; other site
700508010289	substrate binding site [chemical binding]; other site
700508010290	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
700508010291	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700508010292	substrate binding site [chemical binding]; other site
700508010293	ATP binding site [chemical binding]; other site
700508010294	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700508010295	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700508010296	DNA binding site [nucleotide binding]
700508010297	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
700508010298	putative ligand binding site [chemical binding]; other site
700508010299	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700508010300	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700508010301	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
700508010302	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
700508010303	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
700508010304	putative hydrophobic ligand binding site [chemical binding]; other site
700508010305	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700508010306	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
700508010307	Walker A/P-loop; other site
700508010308	ATP binding site [chemical binding]; other site
700508010309	Q-loop/lid; other site
700508010310	ABC transporter signature motif; other site
700508010311	Walker B; other site
700508010312	D-loop; other site
700508010313	H-loop/switch region; other site
700508010314	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
700508010315	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
700508010316	TM-ABC transporter signature motif; other site
700508010317	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
700508010318	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
700508010319	putative ligand binding site [chemical binding]; other site
700508010320	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
700508010321	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508010322	DNA-binding site [nucleotide binding]; DNA binding site
700508010323	UTRA domain; Region: UTRA; pfam07702
700508010324	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
700508010325	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
700508010326	substrate binding site [chemical binding]; other site
700508010327	ATP binding site [chemical binding]; other site
700508010328	KduI/IolB family; Region: KduI; pfam04962
700508010329	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
700508010330	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
700508010331	PYR/PP interface [polypeptide binding]; other site
700508010332	dimer interface [polypeptide binding]; other site
700508010333	TPP binding site [chemical binding]; other site
700508010334	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
700508010335	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
700508010336	TPP-binding site; other site
700508010337	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
700508010338	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
700508010339	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700508010340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
700508010341	Transposase; Region: DDE_Tnp_ISL3; pfam01610
700508010342	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508010343	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508010344	active site
700508010345	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508010346	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508010347	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
700508010348	dimerization interface [polypeptide binding]; other site
700508010349	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
700508010350	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
700508010351	putative molybdopterin cofactor binding site [chemical binding]; other site
700508010352	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
700508010353	putative molybdopterin cofactor binding site; other site
700508010354	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
700508010355	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
700508010356	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
700508010357	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508010358	Walker A motif; other site
700508010359	ATP binding site [chemical binding]; other site
700508010360	Walker B motif; other site
700508010361	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
700508010362	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
700508010363	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
700508010364	oligomer interface [polypeptide binding]; other site
700508010365	active site residues [active]
700508010366	Clp protease; Region: CLP_protease; pfam00574
700508010367	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
700508010368	oligomer interface [polypeptide binding]; other site
700508010369	active site residues [active]
700508010370	trigger factor; Provisional; Region: tig; PRK01490
700508010371	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700508010372	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
700508010373	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700508010374	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
700508010375	active site
700508010376	DNA binding site [nucleotide binding]
700508010377	Int/Topo IB signature motif; other site
700508010378	Helix-turn-helix domain; Region: HTH_17; cl17695
700508010379	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
700508010380	active site
700508010381	Int/Topo IB signature motif; other site
700508010382	Transcriptional regulator; Region: Rrf2; cl17282
700508010383	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
700508010384	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
700508010385	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
700508010386	Phage capsid family; Region: Phage_capsid; pfam05065
700508010387	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
700508010388	HicB family; Region: HicB; pfam05534
700508010389	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508010390	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508010391	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700508010392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508010393	putative substrate translocation pore; other site
700508010394	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
700508010395	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
700508010396	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
700508010397	putative DNA binding site [nucleotide binding]; other site
700508010398	catalytic residue [active]
700508010399	putative H2TH interface [polypeptide binding]; other site
700508010400	putative catalytic residues [active]
700508010401	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
700508010402	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
700508010403	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
700508010404	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508010405	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010406	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
700508010407	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508010408	NAD(P) binding site [chemical binding]; other site
700508010409	active site
700508010410	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
700508010411	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
700508010412	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
700508010413	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
700508010414	nucleoside/Zn binding site; other site
700508010415	dimer interface [polypeptide binding]; other site
700508010416	catalytic motif [active]
700508010417	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
700508010418	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
700508010419	Na binding site [ion binding]; other site
700508010420	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
700508010421	MgtE intracellular N domain; Region: MgtE_N; cl15244
700508010422	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
700508010423	Divalent cation transporter; Region: MgtE; pfam01769
700508010424	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
700508010425	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700508010426	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
700508010427	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
700508010428	Zn binding site [ion binding]; other site
700508010429	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508010430	active site
700508010431	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
700508010432	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508010433	active site
700508010434	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
700508010435	apolar tunnel; other site
700508010436	heme binding site [chemical binding]; other site
700508010437	dimerization interface [polypeptide binding]; other site
700508010438	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
700508010439	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
700508010440	active site
700508010441	catalytic site [active]
700508010442	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
700508010443	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
700508010444	active site
700508010445	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
700508010446	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
700508010447	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508010448	Walker A/P-loop; other site
700508010449	ATP binding site [chemical binding]; other site
700508010450	Q-loop/lid; other site
700508010451	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700508010452	ABC transporter; Region: ABC_tran_2; pfam12848
700508010453	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
700508010454	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
700508010455	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
700508010456	dimer interface [polypeptide binding]; other site
700508010457	ssDNA binding site [nucleotide binding]; other site
700508010458	tetramer (dimer of dimers) interface [polypeptide binding]; other site
700508010459	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
700508010460	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508010461	active site
700508010462	ATP binding site [chemical binding]; other site
700508010463	substrate binding site [chemical binding]; other site
700508010464	activation loop (A-loop); other site
700508010465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
700508010466	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508010467	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508010468	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508010469	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508010470	Copper resistance protein D; Region: CopD; pfam05425
700508010471	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
700508010472	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
700508010473	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
700508010474	putative acyl-acceptor binding pocket; other site
700508010475	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
700508010476	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
700508010477	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700508010478	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
700508010479	putative acyl-acceptor binding pocket; other site
700508010480	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
700508010481	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508010482	Protein of unknown function (DUF3257); Region: DUF3257; pfam11645
700508010483	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508010484	anti sigma factor interaction site; other site
700508010485	regulatory phosphorylation site [posttranslational modification]; other site
700508010486	PAS fold; Region: PAS_2; pfam08446
700508010487	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508010488	GAF domain; Region: GAF; pfam01590
700508010489	Phytochrome region; Region: PHY; pfam00360
700508010490	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
700508010491	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
700508010492	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700508010493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508010494	S-adenosylmethionine binding site [chemical binding]; other site
700508010495	enoyl-CoA hydratase; Provisional; Region: PRK05870
700508010496	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508010497	substrate binding site [chemical binding]; other site
700508010498	oxyanion hole (OAH) forming residues; other site
700508010499	trimer interface [polypeptide binding]; other site
700508010500	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
700508010501	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700508010502	E3 interaction surface; other site
700508010503	lipoyl attachment site [posttranslational modification]; other site
700508010504	e3 binding domain; Region: E3_binding; pfam02817
700508010505	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
700508010506	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
700508010507	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
700508010508	alpha subunit interface [polypeptide binding]; other site
700508010509	TPP binding site [chemical binding]; other site
700508010510	heterodimer interface [polypeptide binding]; other site
700508010511	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
700508010512	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
700508010513	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
700508010514	tetramer interface [polypeptide binding]; other site
700508010515	TPP-binding site [chemical binding]; other site
700508010516	heterodimer interface [polypeptide binding]; other site
700508010517	phosphorylation loop region [posttranslational modification]
700508010518	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
700508010519	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
700508010520	putative active site [active]
700508010521	putative catalytic site [active]
700508010522	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508010523	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508010524	active site
700508010525	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
700508010526	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700508010527	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
700508010528	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
700508010529	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700508010530	carboxyltransferase (CT) interaction site; other site
700508010531	biotinylation site [posttranslational modification]; other site
700508010532	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
700508010533	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
700508010534	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
700508010535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508010536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010537	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
700508010538	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
700508010539	classical (c) SDRs; Region: SDR_c; cd05233
700508010540	NAD(P) binding site [chemical binding]; other site
700508010541	active site
700508010542	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508010543	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
700508010544	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
700508010545	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
700508010546	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
700508010547	putative hydrophobic ligand binding site [chemical binding]; other site
700508010548	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
700508010549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
700508010550	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
700508010551	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
700508010552	Transcriptional regulator [Transcription]; Region: IclR; COG1414
700508010553	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
700508010554	Bacterial transcriptional regulator; Region: IclR; pfam01614
700508010555	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
700508010556	acyl-CoA synthetase; Validated; Region: PRK07787
700508010557	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508010558	acyl-activating enzyme (AAE) consensus motif; other site
700508010559	AMP binding site [chemical binding]; other site
700508010560	active site
700508010561	CoA binding site [chemical binding]; other site
700508010562	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
700508010563	CoenzymeA binding site [chemical binding]; other site
700508010564	subunit interaction site [polypeptide binding]; other site
700508010565	PHB binding site; other site
700508010566	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
700508010567	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
700508010568	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700508010569	catalytic triad [active]
700508010570	hypothetical protein; Provisional; Region: PRK07907
700508010571	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
700508010572	active site
700508010573	metal binding site [ion binding]; metal-binding site
700508010574	dimer interface [polypeptide binding]; other site
700508010575	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
700508010576	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
700508010577	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
700508010578	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
700508010579	phosphate binding site [ion binding]; other site
700508010580	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
700508010581	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
700508010582	putative active site [active]
700508010583	putative catalytic site [active]
700508010584	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
700508010585	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
700508010586	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
700508010587	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
700508010588	putative NAD(P) binding site [chemical binding]; other site
700508010589	active site
700508010590	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
700508010591	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
700508010592	active site
700508010593	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
700508010594	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508010595	DNA binding residues [nucleotide binding]
700508010596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508010597	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508010598	putative substrate translocation pore; other site
700508010599	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
700508010600	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
700508010601	substrate binding site; other site
700508010602	dimer interface; other site
700508010603	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
700508010604	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508010605	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508010606	active site
700508010607	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
700508010608	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508010609	dimer interface [polypeptide binding]; other site
700508010610	active site
700508010611	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508010612	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508010613	Syntaxin 6, N-terminal; Region: Syntaxin-6_N; pfam09177
700508010614	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508010615	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010616	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
700508010617	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010618	Predicted metalloprotease [General function prediction only]; Region: COG2321
700508010619	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
700508010620	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
700508010621	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
700508010622	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
700508010623	short chain dehydrogenase; Provisional; Region: PRK06180
700508010624	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
700508010625	NADP binding site [chemical binding]; other site
700508010626	active site
700508010627	steroid binding site; other site
700508010628	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
700508010629	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
700508010630	DNA binding residues [nucleotide binding]
700508010631	drug binding residues [chemical binding]; other site
700508010632	dimer interface [polypeptide binding]; other site
700508010633	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
700508010634	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
700508010635	nudix motif; other site
700508010636	Glucitol operon activator protein (GutM); Region: GutM; cl01890
700508010637	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
700508010638	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508010639	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508010640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508010641	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
700508010642	active site
700508010643	dimerization interface [polypeptide binding]; other site
700508010644	ribonuclease PH; Reviewed; Region: rph; PRK00173
700508010645	Ribonuclease PH; Region: RNase_PH_bact; cd11362
700508010646	hexamer interface [polypeptide binding]; other site
700508010647	active site
700508010648	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
700508010649	Rhomboid family; Region: Rhomboid; pfam01694
700508010650	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
700508010651	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
700508010652	dimer interface [polypeptide binding]; other site
700508010653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508010654	catalytic residue [active]
700508010655	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
700508010656	MoaE interaction surface [polypeptide binding]; other site
700508010657	MoeB interaction surface [polypeptide binding]; other site
700508010658	thiocarboxylated glycine; other site
700508010659	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
700508010660	MPN+ (JAMM) motif; other site
700508010661	Zinc-binding site [ion binding]; other site
700508010662	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
700508010663	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
700508010664	cleavage site
700508010665	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
700508010666	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
700508010667	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
700508010668	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
700508010669	active site
700508010670	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
700508010671	DEAD/DEAH box helicase; Region: DEAD; pfam00270
700508010672	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
700508010673	putative Mg++ binding site [ion binding]; other site
700508010674	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
700508010675	Predicted metalloprotease [General function prediction only]; Region: COG2321
700508010676	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
700508010677	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
700508010678	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
700508010679	putative homodimer interface [polypeptide binding]; other site
700508010680	putative active site pocket [active]
700508010681	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
700508010682	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
700508010683	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
700508010684	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
700508010685	active site
700508010686	homodimer interface [polypeptide binding]; other site
700508010687	catalytic site [active]
700508010688	acceptor binding site [chemical binding]; other site
700508010689	glycogen branching enzyme; Provisional; Region: PRK05402
700508010690	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
700508010691	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
700508010692	active site
700508010693	catalytic site [active]
700508010694	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
700508010695	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
700508010696	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
700508010697	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
700508010698	putative acyltransferase; Provisional; Region: PRK05790
700508010699	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508010700	dimer interface [polypeptide binding]; other site
700508010701	active site
700508010702	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
700508010703	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508010704	dimer interface [polypeptide binding]; other site
700508010705	substrate binding site [chemical binding]; other site
700508010706	metal binding site [ion binding]; metal-binding site
700508010707	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
700508010708	hypothetical protein; Provisional; Region: PRK03298
700508010709	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700508010710	dimerization interface [polypeptide binding]; other site
700508010711	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700508010712	cyclase homology domain; Region: CHD; cd07302
700508010713	nucleotidyl binding site; other site
700508010714	metal binding site [ion binding]; metal-binding site
700508010715	dimer interface [polypeptide binding]; other site
700508010716	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
700508010717	Glutaminase; Region: Glutaminase; cl00907
700508010718	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
700508010719	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
700508010720	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
700508010721	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
700508010722	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
700508010723	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
700508010724	AlkA N-terminal domain; Region: AlkA_N; pfam06029
700508010725	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
700508010726	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700508010727	minor groove reading motif; other site
700508010728	helix-hairpin-helix signature motif; other site
700508010729	substrate binding pocket [chemical binding]; other site
700508010730	active site
700508010731	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
700508010732	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
700508010733	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
700508010734	DNA binding site [nucleotide binding]
700508010735	active site
700508010736	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
700508010737	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
700508010738	hinge; other site
700508010739	active site
700508010740	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
700508010741	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
700508010742	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
700508010743	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
700508010744	gamma subunit interface [polypeptide binding]; other site
700508010745	epsilon subunit interface [polypeptide binding]; other site
700508010746	LBP interface [polypeptide binding]; other site
700508010747	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
700508010748	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
700508010749	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
700508010750	alpha subunit interaction interface [polypeptide binding]; other site
700508010751	Walker A motif; other site
700508010752	ATP binding site [chemical binding]; other site
700508010753	Walker B motif; other site
700508010754	inhibitor binding site; inhibition site
700508010755	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
700508010756	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
700508010757	core domain interface [polypeptide binding]; other site
700508010758	delta subunit interface [polypeptide binding]; other site
700508010759	epsilon subunit interface [polypeptide binding]; other site
700508010760	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
700508010761	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
700508010762	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
700508010763	beta subunit interaction interface [polypeptide binding]; other site
700508010764	Walker A motif; other site
700508010765	ATP binding site [chemical binding]; other site
700508010766	Walker B motif; other site
700508010767	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
700508010768	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
700508010769	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
700508010770	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
700508010771	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
700508010772	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
700508010773	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
700508010774	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
700508010775	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
700508010776	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
700508010777	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
700508010778	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508010779	S-adenosylmethionine binding site [chemical binding]; other site
700508010780	peptide chain release factor 1; Validated; Region: prfA; PRK00591
700508010781	This domain is found in peptide chain release factors; Region: PCRF; smart00937
700508010782	RF-1 domain; Region: RF-1; pfam00472
700508010783	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
700508010784	acyl-CoA synthetase; Provisional; Region: PRK13388
700508010785	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508010786	acyl-activating enzyme (AAE) consensus motif; other site
700508010787	AMP binding site [chemical binding]; other site
700508010788	active site
700508010789	CoA binding site [chemical binding]; other site
700508010790	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508010791	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010792	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
700508010793	transcription termination factor Rho; Provisional; Region: PRK12608
700508010794	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
700508010795	RNA binding site [nucleotide binding]; other site
700508010796	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
700508010797	multimer interface [polypeptide binding]; other site
700508010798	Walker A motif; other site
700508010799	ATP binding site [chemical binding]; other site
700508010800	Walker B motif; other site
700508010801	threonine synthase; Reviewed; Region: PRK06721
700508010802	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
700508010803	homodimer interface [polypeptide binding]; other site
700508010804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508010805	catalytic residue [active]
700508010806	homoserine dehydrogenase; Provisional; Region: PRK06349
700508010807	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
700508010808	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
700508010809	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
700508010810	diaminopimelate decarboxylase; Region: lysA; TIGR01048
700508010811	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
700508010812	active site
700508010813	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
700508010814	substrate binding site [chemical binding]; other site
700508010815	catalytic residues [active]
700508010816	dimer interface [polypeptide binding]; other site
700508010817	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
700508010818	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
700508010819	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
700508010820	active site
700508010821	HIGH motif; other site
700508010822	KMSK motif region; other site
700508010823	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
700508010824	tRNA binding surface [nucleotide binding]; other site
700508010825	anticodon binding site; other site
700508010826	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508010827	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508010828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508010829	protochlorophyllide reductase; Region: PLN00015
700508010830	NAD(P) binding site [chemical binding]; other site
700508010831	active site
700508010832	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
700508010833	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
700508010834	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700508010835	Histidine kinase; Region: HisKA_3; pfam07730
700508010836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508010837	ATP binding site [chemical binding]; other site
700508010838	Mg2+ binding site [ion binding]; other site
700508010839	G-X-G motif; other site
700508010840	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508010841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508010842	active site
700508010843	phosphorylation site [posttranslational modification]
700508010844	intermolecular recognition site; other site
700508010845	dimerization interface [polypeptide binding]; other site
700508010846	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508010847	DNA binding residues [nucleotide binding]
700508010848	dimerization interface [polypeptide binding]; other site
700508010849	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
700508010850	Rrf2 family protein; Region: rrf2_super; TIGR00738
700508010851	Transcriptional regulator; Region: Rrf2; pfam02082
700508010852	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508010853	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508010854	DNA-binding site [nucleotide binding]; DNA binding site
700508010855	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
700508010856	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700508010857	FAD binding domain; Region: FAD_binding_4; pfam01565
700508010858	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
700508010859	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
700508010860	Isochorismatase family; Region: Isochorismatase; pfam00857
700508010861	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
700508010862	catalytic triad [active]
700508010863	conserved cis-peptide bond; other site
700508010864	Protein of unknown function (DUF664); Region: DUF664; pfam04978
700508010865	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
700508010866	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
700508010867	active site
700508010868	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
700508010869	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
700508010870	CysD dimerization site [polypeptide binding]; other site
700508010871	G1 box; other site
700508010872	putative GEF interaction site [polypeptide binding]; other site
700508010873	GTP/Mg2+ binding site [chemical binding]; other site
700508010874	Switch I region; other site
700508010875	G2 box; other site
700508010876	G3 box; other site
700508010877	Switch II region; other site
700508010878	G4 box; other site
700508010879	G5 box; other site
700508010880	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
700508010881	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
700508010882	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
700508010883	ligand-binding site [chemical binding]; other site
700508010884	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
700508010885	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
700508010886	Active Sites [active]
700508010887	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
700508010888	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700508010889	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
700508010890	Ligand binding site; other site
700508010891	Ligand binding site; other site
700508010892	Ligand binding site; other site
700508010893	Putative Catalytic site; other site
700508010894	DXD motif; other site
700508010895	Predicted membrane protein [Function unknown]; Region: COG2246
700508010896	GtrA-like protein; Region: GtrA; pfam04138
700508010897	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
700508010898	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508010899	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508010900	dimer interface [polypeptide binding]; other site
700508010901	phosphorylation site [posttranslational modification]
700508010902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508010903	ATP binding site [chemical binding]; other site
700508010904	Mg2+ binding site [ion binding]; other site
700508010905	G-X-G motif; other site
700508010906	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508010907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508010908	active site
700508010909	phosphorylation site [posttranslational modification]
700508010910	intermolecular recognition site; other site
700508010911	dimerization interface [polypeptide binding]; other site
700508010912	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508010913	DNA binding site [nucleotide binding]
700508010914	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700508010915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508010916	dimer interface [polypeptide binding]; other site
700508010917	conserved gate region; other site
700508010918	putative PBP binding loops; other site
700508010919	ABC-ATPase subunit interface; other site
700508010920	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
700508010921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508010922	dimer interface [polypeptide binding]; other site
700508010923	conserved gate region; other site
700508010924	putative PBP binding loops; other site
700508010925	ABC-ATPase subunit interface; other site
700508010926	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
700508010927	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508010928	Walker A/P-loop; other site
700508010929	ATP binding site [chemical binding]; other site
700508010930	Q-loop/lid; other site
700508010931	ABC transporter signature motif; other site
700508010932	Walker B; other site
700508010933	D-loop; other site
700508010934	H-loop/switch region; other site
700508010935	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
700508010936	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508010937	Walker A/P-loop; other site
700508010938	ATP binding site [chemical binding]; other site
700508010939	Q-loop/lid; other site
700508010940	ABC transporter signature motif; other site
700508010941	Walker B; other site
700508010942	D-loop; other site
700508010943	H-loop/switch region; other site
700508010944	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
700508010945	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
700508010946	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
700508010947	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
700508010948	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508010949	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
700508010950	active site
700508010951	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508010952	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508010953	AAA domain; Region: AAA_23; pfam13476
700508010954	Walker A/P-loop; other site
700508010955	ATP binding site [chemical binding]; other site
700508010956	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
700508010957	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
700508010958	active site
700508010959	metal binding site [ion binding]; metal-binding site
700508010960	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508010961	catalytic core [active]
700508010962	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
700508010963	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
700508010964	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700508010965	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700508010966	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508010967	Walker A/P-loop; other site
700508010968	ATP binding site [chemical binding]; other site
700508010969	Q-loop/lid; other site
700508010970	ABC transporter signature motif; other site
700508010971	Walker B; other site
700508010972	D-loop; other site
700508010973	H-loop/switch region; other site
700508010974	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700508010975	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
700508010976	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700508010977	Walker A/P-loop; other site
700508010978	ATP binding site [chemical binding]; other site
700508010979	Q-loop/lid; other site
700508010980	ABC transporter signature motif; other site
700508010981	Walker B; other site
700508010982	D-loop; other site
700508010983	H-loop/switch region; other site
700508010984	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
700508010985	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
700508010986	Domain of unknown function (DUF305); Region: DUF305; pfam03713
700508010987	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700508010988	metal-binding site [ion binding]
700508010989	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
700508010990	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
700508010991	metal-binding site [ion binding]
700508010992	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700508010993	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700508010994	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700508010995	cyclase homology domain; Region: CHD; cd07302
700508010996	nucleotidyl binding site; other site
700508010997	metal binding site [ion binding]; metal-binding site
700508010998	dimer interface [polypeptide binding]; other site
700508010999	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
700508011000	HIT family signature motif; other site
700508011001	catalytic residue [active]
700508011002	Domain of unknown function (DUF385); Region: DUF385; pfam04075
700508011003	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
700508011004	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508011005	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
700508011006	Fe-S cluster binding site [ion binding]; other site
700508011007	DNA binding site [nucleotide binding]
700508011008	active site
700508011009	H+ Antiporter protein; Region: 2A0121; TIGR00900
700508011010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508011011	putative substrate translocation pore; other site
700508011012	AAA ATPase domain; Region: AAA_16; pfam13191
700508011013	Walker A motif; other site
700508011014	ATP binding site [chemical binding]; other site
700508011015	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508011016	DNA binding residues [nucleotide binding]
700508011017	FAD binding domain; Region: FAD_binding_4; pfam01565
700508011018	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
700508011019	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700508011020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508011021	Walker A/P-loop; other site
700508011022	ATP binding site [chemical binding]; other site
700508011023	Q-loop/lid; other site
700508011024	ABC transporter signature motif; other site
700508011025	Walker B; other site
700508011026	D-loop; other site
700508011027	H-loop/switch region; other site
700508011028	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
700508011029	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
700508011030	FAD binding pocket [chemical binding]; other site
700508011031	FAD binding motif [chemical binding]; other site
700508011032	phosphate binding motif [ion binding]; other site
700508011033	NAD binding pocket [chemical binding]; other site
700508011034	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700508011035	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
700508011036	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508011037	Walker A/P-loop; other site
700508011038	ATP binding site [chemical binding]; other site
700508011039	Q-loop/lid; other site
700508011040	ABC transporter signature motif; other site
700508011041	Walker B; other site
700508011042	D-loop; other site
700508011043	H-loop/switch region; other site
700508011044	Predicted amidohydrolase [General function prediction only]; Region: COG0388
700508011045	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
700508011046	active site
700508011047	catalytic triad [active]
700508011048	dimer interface [polypeptide binding]; other site
700508011049	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508011050	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508011051	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508011052	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
700508011053	FAD binding pocket [chemical binding]; other site
700508011054	FAD binding motif [chemical binding]; other site
700508011055	phosphate binding motif [ion binding]; other site
700508011056	NAD binding pocket [chemical binding]; other site
700508011057	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
700508011058	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
700508011059	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
700508011060	ATP binding site [chemical binding]; other site
700508011061	Mg++ binding site [ion binding]; other site
700508011062	motif III; other site
700508011063	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508011064	nucleotide binding region [chemical binding]; other site
700508011065	ATP-binding site [chemical binding]; other site
700508011066	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
700508011067	putative RNA binding site [nucleotide binding]; other site
700508011068	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
700508011069	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
700508011070	RNase_H superfamily; Region: RNase_H_2; pfam13482
700508011071	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
700508011072	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508011073	ATP binding site [chemical binding]; other site
700508011074	putative Mg++ binding site [ion binding]; other site
700508011075	AAA domain; Region: AAA_12; pfam13087
700508011076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508011077	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508011078	putative substrate translocation pore; other site
700508011079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508011080	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
700508011081	putative substrate translocation pore; other site
700508011082	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
700508011083	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
700508011084	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
700508011085	TPP-binding site [chemical binding]; other site
700508011086	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
700508011087	dimer interface [polypeptide binding]; other site
700508011088	PYR/PP interface [polypeptide binding]; other site
700508011089	TPP binding site [chemical binding]; other site
700508011090	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508011091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508011092	short chain dehydrogenase; Provisional; Region: PRK08267
700508011093	NAD(P) binding site [chemical binding]; other site
700508011094	active site
700508011095	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
700508011096	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
700508011097	Malic enzyme, N-terminal domain; Region: malic; pfam00390
700508011098	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
700508011099	NAD(P) binding pocket [chemical binding]; other site
700508011100	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
700508011101	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
700508011102	oligomer interface [polypeptide binding]; other site
700508011103	metal binding site [ion binding]; metal-binding site
700508011104	metal binding site [ion binding]; metal-binding site
700508011105	putative Cl binding site [ion binding]; other site
700508011106	basic sphincter; other site
700508011107	hydrophobic gate; other site
700508011108	periplasmic entrance; other site
700508011109	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
700508011110	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
700508011111	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
700508011112	Walker A/P-loop; other site
700508011113	ATP binding site [chemical binding]; other site
700508011114	Q-loop/lid; other site
700508011115	ABC transporter signature motif; other site
700508011116	Walker B; other site
700508011117	D-loop; other site
700508011118	H-loop/switch region; other site
700508011119	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
700508011120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508011121	dimer interface [polypeptide binding]; other site
700508011122	conserved gate region; other site
700508011123	putative PBP binding loops; other site
700508011124	ABC-ATPase subunit interface; other site
700508011125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508011126	dimer interface [polypeptide binding]; other site
700508011127	conserved gate region; other site
700508011128	putative PBP binding loops; other site
700508011129	ABC-ATPase subunit interface; other site
700508011130	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
700508011131	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
700508011132	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700508011133	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
700508011134	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
700508011135	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
700508011136	MgtE intracellular N domain; Region: MgtE_N; smart00924
700508011137	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
700508011138	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
700508011139	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
700508011140	N-acetyl-D-glucosamine binding site [chemical binding]; other site
700508011141	catalytic residue [active]
700508011142	Domain of unknown function DUF59; Region: DUF59; pfam01883
700508011143	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
700508011144	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
700508011145	sec-independent translocase; Provisional; Region: PRK03100
700508011146	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700508011147	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700508011148	protein binding site [polypeptide binding]; other site
700508011149	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
700508011150	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508011151	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508011152	DNA binding residues [nucleotide binding]
700508011153	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
700508011154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508011155	S-adenosylmethionine binding site [chemical binding]; other site
700508011156	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
700508011157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508011158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508011159	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
700508011160	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
700508011161	Walker A/P-loop; other site
700508011162	ATP binding site [chemical binding]; other site
700508011163	Q-loop/lid; other site
700508011164	ABC transporter signature motif; other site
700508011165	Walker B; other site
700508011166	D-loop; other site
700508011167	H-loop/switch region; other site
700508011168	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
700508011169	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
700508011170	PAS domain S-box; Region: sensory_box; TIGR00229
700508011171	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
700508011172	putative active site [active]
700508011173	heme pocket [chemical binding]; other site
700508011174	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508011175	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508011176	metal binding site [ion binding]; metal-binding site
700508011177	active site
700508011178	I-site; other site
700508011179	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
700508011180	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
700508011181	ligand binding site; other site
700508011182	oligomer interface; other site
700508011183	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
700508011184	dimer interface [polypeptide binding]; other site
700508011185	N-terminal domain interface [polypeptide binding]; other site
700508011186	sulfate 1 binding site; other site
700508011187	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
700508011188	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700508011189	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
700508011190	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
700508011191	DivIVA domain; Region: DivI1A_domain; TIGR03544
700508011192	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
700508011193	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
700508011194	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
700508011195	dihydropteroate synthase; Region: DHPS; TIGR01496
700508011196	substrate binding pocket [chemical binding]; other site
700508011197	dimer interface [polypeptide binding]; other site
700508011198	inhibitor binding site; inhibition site
700508011199	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
700508011200	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
700508011201	acyl-activating enzyme (AAE) consensus motif; other site
700508011202	putative AMP binding site [chemical binding]; other site
700508011203	putative active site [active]
700508011204	putative CoA binding site [chemical binding]; other site
700508011205	TIGR00730 family protein; Region: TIGR00730
700508011206	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
700508011207	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
700508011208	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
700508011209	metal binding site [ion binding]; metal-binding site
700508011210	putative dimer interface [polypeptide binding]; other site
700508011211	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
700508011212	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
700508011213	putative trimer interface [polypeptide binding]; other site
700508011214	putative CoA binding site [chemical binding]; other site
700508011215	acyl-CoA synthetase; Validated; Region: PRK07787
700508011216	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508011217	acyl-activating enzyme (AAE) consensus motif; other site
700508011218	AMP binding site [chemical binding]; other site
700508011219	active site
700508011220	CoA binding site [chemical binding]; other site
700508011221	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
700508011222	dimer interface [polypeptide binding]; other site
700508011223	active site
700508011224	ADP-ribose binding site [chemical binding]; other site
700508011225	nudix motif; other site
700508011226	metal binding site [ion binding]; metal-binding site
700508011227	Proline dehydrogenase; Region: Pro_dh; cl03282
700508011228	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
700508011229	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
700508011230	Glutamate binding site [chemical binding]; other site
700508011231	NAD binding site [chemical binding]; other site
700508011232	catalytic residues [active]
700508011233	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508011234	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
700508011235	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
700508011236	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508011237	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508011238	homodimer interface [polypeptide binding]; other site
700508011239	catalytic residue [active]
700508011240	Ferredoxin [Energy production and conversion]; Region: COG1146
700508011241	4Fe-4S binding domain; Region: Fer4; pfam00037
700508011242	Predicted transcriptional regulators [Transcription]; Region: COG1695
700508011243	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
700508011244	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
700508011245	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700508011246	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
700508011247	active site
700508011248	FMN binding site [chemical binding]; other site
700508011249	2,4-decadienoyl-CoA binding site; other site
700508011250	catalytic residue [active]
700508011251	4Fe-4S cluster binding site [ion binding]; other site
700508011252	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
700508011253	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508011254	Uncharacterized conserved protein [Function unknown]; Region: COG2353
700508011255	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
700508011256	classical (c) SDRs; Region: SDR_c; cd05233
700508011257	NAD(P) binding site [chemical binding]; other site
700508011258	active site
700508011259	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508011260	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508011261	DNA binding residues [nucleotide binding]
700508011262	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700508011263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508011264	NAD(P) binding site [chemical binding]; other site
700508011265	active site
700508011266	AAA ATPase domain; Region: AAA_16; pfam13191
700508011267	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508011268	DNA binding residues [nucleotide binding]
700508011269	dimerization interface [polypeptide binding]; other site
700508011270	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508011271	FO synthase; Reviewed; Region: fbiC; PRK09234
700508011272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508011273	FeS/SAM binding site; other site
700508011274	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508011275	FeS/SAM binding site; other site
700508011276	transcription termination factor Rho; Provisional; Region: PRK12678
700508011277	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
700508011278	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
700508011279	Cl- selectivity filter; other site
700508011280	Cl- binding residues [ion binding]; other site
700508011281	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
700508011282	pore gating glutamate residue; other site
700508011283	dimer interface [polypeptide binding]; other site
700508011284	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
700508011285	dihydroxyacetone kinase; Provisional; Region: PRK14479
700508011286	DAK2 domain; Region: Dak2; pfam02734
700508011287	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
700508011288	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
700508011289	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
700508011290	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
700508011291	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
700508011292	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
700508011293	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
700508011294	G1 box; other site
700508011295	putative GEF interaction site [polypeptide binding]; other site
700508011296	GTP/Mg2+ binding site [chemical binding]; other site
700508011297	Switch I region; other site
700508011298	G2 box; other site
700508011299	G3 box; other site
700508011300	Switch II region; other site
700508011301	G4 box; other site
700508011302	G5 box; other site
700508011303	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
700508011304	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
700508011305	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
700508011306	active site
700508011307	8-oxo-dGMP binding site [chemical binding]; other site
700508011308	nudix motif; other site
700508011309	metal binding site [ion binding]; metal-binding site
700508011310	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
700508011311	aromatic arch; other site
700508011312	DCoH dimer interaction site [polypeptide binding]; other site
700508011313	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
700508011314	DCoH tetramer interaction site [polypeptide binding]; other site
700508011315	substrate binding site [chemical binding]; other site
700508011316	mannosyltransferase; Provisional; Region: pimE; PRK13375
700508011317	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
700508011318	FMN binding site [chemical binding]; other site
700508011319	dimer interface [polypeptide binding]; other site
700508011320	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
700508011321	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
700508011322	metal binding site [ion binding]; metal-binding site
700508011323	putative dimer interface [polypeptide binding]; other site
700508011324	Histidine kinase; Region: His_kinase; pfam06580
700508011325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508011326	ATP binding site [chemical binding]; other site
700508011327	Mg2+ binding site [ion binding]; other site
700508011328	G-X-G motif; other site
700508011329	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
700508011330	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508011331	active site
700508011332	phosphorylation site [posttranslational modification]
700508011333	intermolecular recognition site; other site
700508011334	dimerization interface [polypeptide binding]; other site
700508011335	LytTr DNA-binding domain; Region: LytTR; smart00850
700508011336	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
700508011337	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
700508011338	Na binding site [ion binding]; other site
700508011339	Protein of unknown function, DUF485; Region: DUF485; pfam04341
700508011340	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
700508011341	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
700508011342	Na binding site [ion binding]; other site
700508011343	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
700508011344	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
700508011345	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
700508011346	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
700508011347	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508011348	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
700508011349	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
700508011350	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508011351	DNA-binding site [nucleotide binding]; DNA binding site
700508011352	NAD-dependent deacetylase; Provisional; Region: PRK00481
700508011353	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
700508011354	NAD+ binding site [chemical binding]; other site
700508011355	substrate binding site [chemical binding]; other site
700508011356	Zn binding site [ion binding]; other site
700508011357	Methyltransferase domain; Region: Methyltransf_23; pfam13489
700508011358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508011359	S-adenosylmethionine binding site [chemical binding]; other site
700508011360	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508011361	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508011362	WHG domain; Region: WHG; pfam13305
700508011363	MMPL family; Region: MMPL; pfam03176
700508011364	MMPL family; Region: MMPL; pfam03176
700508011365	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
700508011366	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700508011367	FMN binding site [chemical binding]; other site
700508011368	substrate binding site [chemical binding]; other site
700508011369	putative catalytic residue [active]
700508011370	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
700508011371	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
700508011372	NAD binding site [chemical binding]; other site
700508011373	homodimer interface [polypeptide binding]; other site
700508011374	homotetramer interface [polypeptide binding]; other site
700508011375	active site
700508011376	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508011377	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508011378	enoyl-CoA hydratase; Provisional; Region: PRK06688
700508011379	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508011380	substrate binding site [chemical binding]; other site
700508011381	oxyanion hole (OAH) forming residues; other site
700508011382	trimer interface [polypeptide binding]; other site
700508011383	H+ Antiporter protein; Region: 2A0121; TIGR00900
700508011384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508011385	CAAX protease self-immunity; Region: Abi; pfam02517
700508011386	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
700508011387	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508011388	NAD(P) binding site [chemical binding]; other site
700508011389	active site
700508011390	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
700508011391	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
700508011392	trimer interface [polypeptide binding]; other site
700508011393	putative metal binding site [ion binding]; other site
700508011394	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
700508011395	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
700508011396	conserved cys residue [active]
700508011397	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508011398	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508011399	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508011400	Fasciclin domain; Region: Fasciclin; pfam02469
700508011401	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508011402	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508011403	active site
700508011404	enoyl-CoA hydratase; Provisional; Region: PRK08252
700508011405	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508011406	substrate binding site [chemical binding]; other site
700508011407	oxyanion hole (OAH) forming residues; other site
700508011408	trimer interface [polypeptide binding]; other site
700508011409	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
700508011410	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508011411	dimer interface [polypeptide binding]; other site
700508011412	active site
700508011413	Transcriptional regulators [Transcription]; Region: FadR; COG2186
700508011414	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508011415	FCD domain; Region: FCD; pfam07729
700508011416	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
700508011417	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
700508011418	nudix motif; other site
700508011419	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
700508011420	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
700508011421	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
700508011422	Predicted membrane protein [Function unknown]; Region: COG2259
700508011423	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
700508011424	homotrimer interaction site [polypeptide binding]; other site
700508011425	putative active site [active]
700508011426	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508011427	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508011428	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508011429	mce related protein; Region: MCE; pfam02470
700508011430	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508011431	mce related protein; Region: MCE; pfam02470
700508011432	mce related protein; Region: MCE; pfam02470
700508011433	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508011434	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508011435	mce related protein; Region: MCE; pfam02470
700508011436	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508011437	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508011438	mce related protein; Region: MCE; pfam02470
700508011439	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508011440	mce related protein; Region: MCE; pfam02470
700508011441	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508011442	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508011443	Permease; Region: Permease; pfam02405
700508011444	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508011445	Permease; Region: Permease; pfam02405
700508011446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508011447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508011448	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508011449	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508011450	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
700508011451	hypothetical protein; Provisional; Region: PRK06149
700508011452	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
700508011453	active site
700508011454	ATP binding site [chemical binding]; other site
700508011455	substrate binding site [chemical binding]; other site
700508011456	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
700508011457	inhibitor-cofactor binding pocket; inhibition site
700508011458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508011459	catalytic residue [active]
700508011460	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
700508011461	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
700508011462	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
700508011463	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508011464	Cytochrome P450; Region: p450; cl12078
700508011465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508011466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508011467	RibD C-terminal domain; Region: RibD_C; cl17279
700508011468	AAA domain; Region: AAA_33; pfam13671
700508011469	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
700508011470	active site
700508011471	Shikimate kinase; Region: SKI; pfam01202
700508011472	Domain of unknown function (DU1801); Region: DUF1801; cl17490
700508011473	GTP-binding protein YchF; Reviewed; Region: PRK09601
700508011474	YchF GTPase; Region: YchF; cd01900
700508011475	G1 box; other site
700508011476	GTP/Mg2+ binding site [chemical binding]; other site
700508011477	Switch I region; other site
700508011478	G2 box; other site
700508011479	Switch II region; other site
700508011480	G3 box; other site
700508011481	G4 box; other site
700508011482	G5 box; other site
700508011483	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
700508011484	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
700508011485	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
700508011486	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
700508011487	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
700508011488	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
700508011489	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
700508011490	generic binding surface II; other site
700508011491	generic binding surface I; other site
700508011492	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
700508011493	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
700508011494	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
700508011495	putative NAD(P) binding site [chemical binding]; other site
700508011496	active site
700508011497	putative substrate binding site [chemical binding]; other site
700508011498	extended (e) SDRs; Region: SDR_e; cd08946
700508011499	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700508011500	NAD(P) binding site [chemical binding]; other site
700508011501	active site
700508011502	substrate binding site [chemical binding]; other site
700508011503	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508011504	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508011505	NAD(P) binding site [chemical binding]; other site
700508011506	active site
700508011507	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
700508011508	Domain of unknown function DUF20; Region: UPF0118; pfam01594
700508011509	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
700508011510	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
700508011511	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
700508011512	putative active site [active]
700508011513	fumarate hydratase; Reviewed; Region: fumC; PRK00485
700508011514	Class II fumarases; Region: Fumarase_classII; cd01362
700508011515	active site
700508011516	tetramer interface [polypeptide binding]; other site
700508011517	PRC-barrel domain; Region: PRC; pfam05239
700508011518	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700508011519	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
700508011520	NodB motif; other site
700508011521	active site
700508011522	catalytic site [active]
700508011523	metal binding site [ion binding]; metal-binding site
700508011524	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
700508011525	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
700508011526	putative active site [active]
700508011527	PhoH-like protein; Region: PhoH; pfam02562
700508011528	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
700508011529	dinuclear metal binding motif [ion binding]; other site
700508011530	serine hydroxymethyltransferase; Provisional; Region: PRK13580
700508011531	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
700508011532	dimer interface [polypeptide binding]; other site
700508011533	active site
700508011534	glycine-pyridoxal phosphate binding site [chemical binding]; other site
700508011535	folate binding site [chemical binding]; other site
700508011536	pantothenate kinase; Provisional; Region: PRK05439
700508011537	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
700508011538	ATP-binding site [chemical binding]; other site
700508011539	CoA-binding site [chemical binding]; other site
700508011540	Mg2+-binding site [ion binding]; other site
700508011541	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
700508011542	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
700508011543	catalytic residue [active]
700508011544	putative FPP diphosphate  binding site; other site
700508011545	putative FPP binding hydrophobic cleft; other site
700508011546	dimer interface [polypeptide binding]; other site
700508011547	putative IPP diphosphate binding site; other site
700508011548	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
700508011549	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
700508011550	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700508011551	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
700508011552	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
700508011553	catalytic residues [active]
700508011554	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
700508011555	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
700508011556	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
700508011557	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
700508011558	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
700508011559	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
700508011560	cystathionine gamma-synthase; Provisional; Region: PRK07811
700508011561	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
700508011562	homodimer interface [polypeptide binding]; other site
700508011563	substrate-cofactor binding pocket; other site
700508011564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508011565	catalytic residue [active]
700508011566	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
700508011567	RDD family; Region: RDD; pfam06271
700508011568	RDD family; Region: RDD; pfam06271
700508011569	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
700508011570	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
700508011571	dimer interface [polypeptide binding]; other site
700508011572	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508011573	catalytic residue [active]
700508011574	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
700508011575	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
700508011576	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
700508011577	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
700508011578	active site
700508011579	catalytic triad [active]
700508011580	oxyanion hole [active]
700508011581	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
700508011582	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508011583	dimer interface [polypeptide binding]; other site
700508011584	active site
700508011585	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
700508011586	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
700508011587	ATP-grasp domain; Region: ATP-grasp; pfam02222
700508011588	Bax inhibitor 1 like; Region: BaxI_1; cl17691
700508011589	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
700508011590	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508011591	substrate binding site [chemical binding]; other site
700508011592	oxyanion hole (OAH) forming residues; other site
700508011593	trimer interface [polypeptide binding]; other site
700508011594	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
700508011595	enoyl-CoA hydratase; Provisional; Region: PRK05862
700508011596	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508011597	substrate binding site [chemical binding]; other site
700508011598	oxyanion hole (OAH) forming residues; other site
700508011599	trimer interface [polypeptide binding]; other site
700508011600	Predicted membrane protein [Function unknown]; Region: COG4425
700508011601	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
700508011602	Rhodanese Homology Domain; Region: RHOD; smart00450
700508011603	active site residue [active]
700508011604	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
700508011605	hypothetical protein; Provisional; Region: PRK10279
700508011606	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
700508011607	active site
700508011608	nucleophile elbow; other site
700508011609	Patatin-like phospholipase; Region: Patatin; pfam01734
700508011610	nucleophile elbow; other site
700508011611	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
700508011612	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
700508011613	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
700508011614	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
700508011615	DNA binding site [nucleotide binding]
700508011616	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
700508011617	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
700508011618	phosphopeptide binding site; other site
700508011619	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508011620	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508011621	active site
700508011622	ATP binding site [chemical binding]; other site
700508011623	substrate binding site [chemical binding]; other site
700508011624	activation loop (A-loop); other site
700508011625	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508011626	lipid-transfer protein; Provisional; Region: PRK08256
700508011627	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508011628	active site
700508011629	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
700508011630	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
700508011631	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
700508011632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508011633	active site
700508011634	phosphorylation site [posttranslational modification]
700508011635	intermolecular recognition site; other site
700508011636	dimerization interface [polypeptide binding]; other site
700508011637	Homeodomain-like domain; Region: HTH_23; pfam13384
700508011638	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
700508011639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508011640	ATP binding site [chemical binding]; other site
700508011641	Mg2+ binding site [ion binding]; other site
700508011642	G-X-G motif; other site
700508011643	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
700508011644	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
700508011645	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
700508011646	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
700508011647	amidase catalytic site [active]
700508011648	Zn binding residues [ion binding]; other site
700508011649	substrate binding site [chemical binding]; other site
700508011650	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
700508011651	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700508011652	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700508011653	Walker A/P-loop; other site
700508011654	ATP binding site [chemical binding]; other site
700508011655	Q-loop/lid; other site
700508011656	ABC transporter signature motif; other site
700508011657	Walker B; other site
700508011658	D-loop; other site
700508011659	H-loop/switch region; other site
700508011660	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
700508011661	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508011662	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508011663	substrate binding pocket [chemical binding]; other site
700508011664	membrane-bound complex binding site; other site
700508011665	hinge residues; other site
700508011666	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700508011667	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508011668	dimer interface [polypeptide binding]; other site
700508011669	conserved gate region; other site
700508011670	putative PBP binding loops; other site
700508011671	ABC-ATPase subunit interface; other site
700508011672	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
700508011673	Acyltransferase family; Region: Acyl_transf_3; pfam01757
700508011674	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
700508011675	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
700508011676	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508011677	dimerization interface [polypeptide binding]; other site
700508011678	putative DNA binding site [nucleotide binding]; other site
700508011679	putative Zn2+ binding site [ion binding]; other site
700508011680	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
700508011681	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
700508011682	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
700508011683	NAD(P) binding site [chemical binding]; other site
700508011684	catalytic residues [active]
700508011685	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
700508011686	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
700508011687	Spore germination protein; Region: Spore_permease; cl17796
700508011688	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
700508011689	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
700508011690	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508011691	Domain of unknown function (DUF385); Region: DUF385; cl04387
700508011692	Putative amidase domain; Region: Amidase_6; pfam12671
700508011693	AAA domain; Region: AAA_23; pfam13476
700508011694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508011695	Walker A/P-loop; other site
700508011696	ATP binding site [chemical binding]; other site
700508011697	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
700508011698	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508011699	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508011700	active site
700508011701	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
700508011702	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
700508011703	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700508011704	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700508011705	K+-transporting ATPase, c chain; Region: KdpC; cl00944
700508011706	K+-transporting ATPase, c chain; Region: KdpC; cl00944
700508011707	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
700508011708	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
700508011709	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
700508011710	Ligand Binding Site [chemical binding]; other site
700508011711	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508011712	dimer interface [polypeptide binding]; other site
700508011713	phosphorylation site [posttranslational modification]
700508011714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508011715	ATP binding site [chemical binding]; other site
700508011716	Mg2+ binding site [ion binding]; other site
700508011717	G-X-G motif; other site
700508011718	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
700508011719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508011720	active site
700508011721	phosphorylation site [posttranslational modification]
700508011722	intermolecular recognition site; other site
700508011723	dimerization interface [polypeptide binding]; other site
700508011724	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508011725	DNA binding site [nucleotide binding]
700508011726	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
700508011727	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
700508011728	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
700508011729	Ligand Binding Site [chemical binding]; other site
700508011730	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
700508011731	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
700508011732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508011733	TIGR03086 family protein; Region: TIGR03086
700508011734	DinB superfamily; Region: DinB_2; pfam12867
700508011735	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
700508011736	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508011737	acyl-activating enzyme (AAE) consensus motif; other site
700508011738	AMP binding site [chemical binding]; other site
700508011739	active site
700508011740	CoA binding site [chemical binding]; other site
700508011741	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
700508011742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508011743	dimer interface [polypeptide binding]; other site
700508011744	conserved gate region; other site
700508011745	ABC-ATPase subunit interface; other site
700508011746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508011747	dimer interface [polypeptide binding]; other site
700508011748	conserved gate region; other site
700508011749	ABC-ATPase subunit interface; other site
700508011750	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
700508011751	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
700508011752	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
700508011753	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700508011754	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
700508011755	dimerization interface [polypeptide binding]; other site
700508011756	putative DNA binding site [nucleotide binding]; other site
700508011757	putative Zn2+ binding site [ion binding]; other site
700508011758	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
700508011759	exopolyphosphatase; Region: exo_poly_only; TIGR03706
700508011760	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
700508011761	Uncharacterized conserved protein [Function unknown]; Region: COG1507
700508011762	Septum formation initiator; Region: DivIC; pfam04977
700508011763	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
700508011764	enolase; Provisional; Region: eno; PRK00077
700508011765	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
700508011766	dimer interface [polypeptide binding]; other site
700508011767	metal binding site [ion binding]; metal-binding site
700508011768	substrate binding pocket [chemical binding]; other site
700508011769	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
700508011770	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
700508011771	N-acetyl-D-glucosamine binding site [chemical binding]; other site
700508011772	Imelysin; Region: Peptidase_M75; pfam09375
700508011773	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
700508011774	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
700508011775	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
700508011776	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
700508011777	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
700508011778	Protein of unknown function (DUF461); Region: DUF461; pfam04314
700508011779	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
700508011780	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
700508011781	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
700508011782	E3 interaction surface; other site
700508011783	lipoyl attachment site [posttranslational modification]; other site
700508011784	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
700508011785	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
700508011786	TPP-binding site [chemical binding]; other site
700508011787	PYR/PP interface [polypeptide binding]; other site
700508011788	dimer interface [polypeptide binding]; other site
700508011789	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
700508011790	TPP binding site [chemical binding]; other site
700508011791	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508011792	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508011793	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508011794	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508011795	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
700508011796	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
700508011797	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
700508011798	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508011799	substrate binding site [chemical binding]; other site
700508011800	oxyanion hole (OAH) forming residues; other site
700508011801	trimer interface [polypeptide binding]; other site
700508011802	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508011803	enoyl-CoA hydratase; Provisional; Region: PRK06190
700508011804	substrate binding site [chemical binding]; other site
700508011805	oxyanion hole (OAH) forming residues; other site
700508011806	trimer interface [polypeptide binding]; other site
700508011807	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
700508011808	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508011809	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508011810	acyl-activating enzyme (AAE) consensus motif; other site
700508011811	AMP binding site [chemical binding]; other site
700508011812	active site
700508011813	CoA binding site [chemical binding]; other site
700508011814	Creatinine amidohydrolase; Region: Creatininase; pfam02633
700508011815	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
700508011816	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
700508011817	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
700508011818	acyl-CoA synthetase; Validated; Region: PRK08162
700508011819	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
700508011820	acyl-activating enzyme (AAE) consensus motif; other site
700508011821	putative active site [active]
700508011822	AMP binding site [chemical binding]; other site
700508011823	putative CoA binding site [chemical binding]; other site
700508011824	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508011825	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
700508011826	FAD binding site [chemical binding]; other site
700508011827	homotetramer interface [polypeptide binding]; other site
700508011828	substrate binding pocket [chemical binding]; other site
700508011829	catalytic base [active]
700508011830	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
700508011831	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
700508011832	homodimer interface [polypeptide binding]; other site
700508011833	metal binding site [ion binding]; metal-binding site
700508011834	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
700508011835	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
700508011836	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508011837	ATP binding site [chemical binding]; other site
700508011838	putative Mg++ binding site [ion binding]; other site
700508011839	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508011840	nucleotide binding region [chemical binding]; other site
700508011841	ATP-binding site [chemical binding]; other site
700508011842	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
700508011843	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
700508011844	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
700508011845	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508011846	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508011847	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
700508011848	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
700508011849	Substrate binding site; other site
700508011850	Mg++ binding site; other site
700508011851	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
700508011852	active site
700508011853	substrate binding site [chemical binding]; other site
700508011854	CoA binding site [chemical binding]; other site
700508011855	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
700508011856	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
700508011857	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700508011858	active site
700508011859	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
700508011860	ArsC family; Region: ArsC; pfam03960
700508011861	catalytic residues [active]
700508011862	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
700508011863	short chain dehydrogenase; Provisional; Region: PRK05854
700508011864	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
700508011865	putative NAD(P) binding site [chemical binding]; other site
700508011866	active site
700508011867	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
700508011868	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
700508011869	5S rRNA interface [nucleotide binding]; other site
700508011870	CTC domain interface [polypeptide binding]; other site
700508011871	L16 interface [polypeptide binding]; other site
700508011872	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
700508011873	putative active site [active]
700508011874	catalytic residue [active]
700508011875	Protein of unknown function (DUF998); Region: DUF998; pfam06197
700508011876	ADDz for ATRX, Dnmt3 and Dnmt3l PHD-like zinc finger domain; Region: ADDz; cl17040
700508011877	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
700508011878	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508011879	acyl-activating enzyme (AAE) consensus motif; other site
700508011880	AMP binding site [chemical binding]; other site
700508011881	active site
700508011882	CoA binding site [chemical binding]; other site
700508011883	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
700508011884	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
700508011885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
700508011886	Domain of unknown function (DUF348); Region: DUF348; pfam03990
700508011887	Domain of unknown function (DUF348); Region: DUF348; pfam03990
700508011888	Domain of unknown function (DUF348); Region: DUF348; pfam03990
700508011889	G5 domain; Region: G5; pfam07501
700508011890	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
700508011891	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
700508011892	active site
700508011893	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
700508011894	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
700508011895	active site
700508011896	HIGH motif; other site
700508011897	KMSKS motif; other site
700508011898	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
700508011899	tRNA binding surface [nucleotide binding]; other site
700508011900	anticodon binding site; other site
700508011901	glutamate dehydrogenase; Provisional; Region: PRK09414
700508011902	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
700508011903	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
700508011904	NAD(P) binding site [chemical binding]; other site
700508011905	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
700508011906	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
700508011907	putative DNA binding site [nucleotide binding]; other site
700508011908	putative Zn2+ binding site [ion binding]; other site
700508011909	AsnC family; Region: AsnC_trans_reg; pfam01037
700508011910	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
700508011911	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
700508011912	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
700508011913	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508011914	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508011915	DNA binding residues [nucleotide binding]
700508011916	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
700508011917	chorismate binding enzyme; Region: Chorismate_bind; cl10555
700508011918	Predicted methyltransferases [General function prediction only]; Region: COG0313
700508011919	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
700508011920	putative SAM binding site [chemical binding]; other site
700508011921	putative homodimer interface [polypeptide binding]; other site
700508011922	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
700508011923	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
700508011924	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
700508011925	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
700508011926	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
700508011927	DNA photolyase; Region: DNA_photolyase; pfam00875
700508011928	arginine deiminase; Provisional; Region: PRK01388
700508011929	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
700508011930	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
700508011931	DNA binding residues [nucleotide binding]
700508011932	dimer interface [polypeptide binding]; other site
700508011933	[2Fe-2S] cluster binding site [ion binding]; other site
700508011934	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
700508011935	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
700508011936	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
700508011937	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
700508011938	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
700508011939	shikimate binding site; other site
700508011940	NAD(P) binding site [chemical binding]; other site
700508011941	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700508011942	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700508011943	ligand binding site [chemical binding]; other site
700508011944	flexible hinge region; other site
700508011945	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
700508011946	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700508011947	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508011948	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508011949	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
700508011950	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
700508011951	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
700508011952	Moco binding site; other site
700508011953	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
700508011954	metal coordination site [ion binding]; other site
700508011955	Helix-turn-helix domain; Region: HTH_31; pfam13560
700508011956	short chain dehydrogenase; Provisional; Region: PRK05854
700508011957	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508011958	NAD(P) binding site [chemical binding]; other site
700508011959	active site
700508011960	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508011961	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508011962	metal binding site [ion binding]; metal-binding site
700508011963	active site
700508011964	I-site; other site
700508011965	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
700508011966	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
700508011967	[2Fe-2S] cluster binding site [ion binding]; other site
700508011968	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
700508011969	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
700508011970	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
700508011971	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
700508011972	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
700508011973	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
700508011974	dimer interface [polypeptide binding]; other site
700508011975	putative functional site; other site
700508011976	putative MPT binding site; other site
700508011977	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
700508011978	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
700508011979	active site
700508011980	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
700508011981	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
700508011982	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
700508011983	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
700508011984	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
700508011985	MspA; Region: MspA; pfam09203
700508011986	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
700508011987	MPT binding site; other site
700508011988	trimer interface [polypeptide binding]; other site
700508011989	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
700508011990	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700508011991	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700508011992	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508011993	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700508011994	dimerization interface [polypeptide binding]; other site
700508011995	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508011996	dimer interface [polypeptide binding]; other site
700508011997	phosphorylation site [posttranslational modification]
700508011998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508011999	ATP binding site [chemical binding]; other site
700508012000	Mg2+ binding site [ion binding]; other site
700508012001	G-X-G motif; other site
700508012002	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508012003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508012004	active site
700508012005	phosphorylation site [posttranslational modification]
700508012006	intermolecular recognition site; other site
700508012007	dimerization interface [polypeptide binding]; other site
700508012008	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508012009	DNA binding site [nucleotide binding]
700508012010	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
700508012011	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508012012	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508012013	active site
700508012014	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
700508012015	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
700508012016	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
700508012017	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
700508012018	ATP-grasp domain; Region: ATP-grasp_4; cl17255
700508012019	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
700508012020	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
700508012021	carboxyltransferase (CT) interaction site; other site
700508012022	biotinylation site [posttranslational modification]; other site
700508012023	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508012024	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
700508012025	active site
700508012026	enoyl-CoA hydratase; Provisional; Region: PRK07827
700508012027	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508012028	substrate binding site [chemical binding]; other site
700508012029	oxyanion hole (OAH) forming residues; other site
700508012030	trimer interface [polypeptide binding]; other site
700508012031	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
700508012032	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
700508012033	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
700508012034	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
700508012035	metal ion-dependent adhesion site (MIDAS); other site
700508012036	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
700508012037	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
700508012038	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
700508012039	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
700508012040	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
700508012041	purine monophosphate binding site [chemical binding]; other site
700508012042	dimer interface [polypeptide binding]; other site
700508012043	putative catalytic residues [active]
700508012044	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
700508012045	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
700508012046	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
700508012047	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
700508012048	active site
700508012049	substrate binding site [chemical binding]; other site
700508012050	cosubstrate binding site; other site
700508012051	catalytic site [active]
700508012052	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
700508012053	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
700508012054	active site
700508012055	dimer interface [polypeptide binding]; other site
700508012056	non-prolyl cis peptide bond; other site
700508012057	insertion regions; other site
700508012058	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
700508012059	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508012060	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
700508012061	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
700508012062	active site
700508012063	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
700508012064	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508012065	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
700508012066	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508012067	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
700508012068	CoA binding domain; Region: CoA_binding; smart00881
700508012069	CoA-ligase; Region: Ligase_CoA; pfam00549
700508012070	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
700508012071	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
700508012072	CoA-ligase; Region: Ligase_CoA; pfam00549
700508012073	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
700508012074	Peptidase family M23; Region: Peptidase_M23; pfam01551
700508012075	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
700508012076	Part of AAA domain; Region: AAA_19; pfam13245
700508012077	Family description; Region: UvrD_C_2; pfam13538
700508012078	hypothetical protein; Provisional; Region: PRK07857
700508012079	succinic semialdehyde dehydrogenase; Region: PLN02278
700508012080	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
700508012081	tetramerization interface [polypeptide binding]; other site
700508012082	NAD(P) binding site [chemical binding]; other site
700508012083	catalytic residues [active]
700508012084	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
700508012085	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
700508012086	active site
700508012087	dimer interface [polypeptide binding]; other site
700508012088	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
700508012089	dimer interface [polypeptide binding]; other site
700508012090	active site
700508012091	short chain dehydrogenase; Provisional; Region: PRK08251
700508012092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508012093	NAD(P) binding site [chemical binding]; other site
700508012094	active site
700508012095	Uncharacterized conserved protein [Function unknown]; Region: COG2966
700508012096	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
700508012097	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
700508012098	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
700508012099	putative DNA binding site [nucleotide binding]; other site
700508012100	catalytic residue [active]
700508012101	putative H2TH interface [polypeptide binding]; other site
700508012102	putative catalytic residues [active]
700508012103	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
700508012104	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
700508012105	Predicted membrane protein [Function unknown]; Region: COG1289
700508012106	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
700508012107	Predicted membrane protein [Function unknown]; Region: COG1950
700508012108	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
700508012109	active site
700508012110	SAM binding site [chemical binding]; other site
700508012111	homodimer interface [polypeptide binding]; other site
700508012112	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
700508012113	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508012114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508012115	S-adenosylmethionine binding site [chemical binding]; other site
700508012116	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
700508012117	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700508012118	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700508012119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508012120	putative substrate translocation pore; other site
700508012121	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
700508012122	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
700508012123	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
700508012124	substrate binding pocket [chemical binding]; other site
700508012125	chain length determination region; other site
700508012126	substrate-Mg2+ binding site; other site
700508012127	catalytic residues [active]
700508012128	aspartate-rich region 1; other site
700508012129	active site lid residues [active]
700508012130	aspartate-rich region 2; other site
700508012131	phytoene desaturase; Region: crtI_fam; TIGR02734
700508012132	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
700508012133	active site lid residues [active]
700508012134	substrate binding pocket [chemical binding]; other site
700508012135	catalytic residues [active]
700508012136	substrate-Mg2+ binding site; other site
700508012137	aspartate-rich region 1; other site
700508012138	aspartate-rich region 2; other site
700508012139	Methyltransferase domain; Region: Methyltransf_31; pfam13847
700508012140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508012141	S-adenosylmethionine binding site [chemical binding]; other site
700508012142	Uncharacterized conserved protein [Function unknown]; Region: COG3349
700508012143	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508012144	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
700508012145	[2Fe-2S] cluster binding site [ion binding]; other site
700508012146	iron-sulfur cluster [ion binding]; other site
700508012147	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
700508012148	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
700508012149	active site
700508012150	metal binding site [ion binding]; metal-binding site
700508012151	nudix motif; other site
700508012152	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508012153	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508012154	metal binding site [ion binding]; metal-binding site
700508012155	active site
700508012156	I-site; other site
700508012157	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
700508012158	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
700508012159	nucleotide binding site [chemical binding]; other site
700508012160	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
700508012161	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
700508012162	active site
700508012163	DNA binding site [nucleotide binding]
700508012164	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
700508012165	DNA binding site [nucleotide binding]
700508012166	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
700508012167	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
700508012168	putative DNA binding site [nucleotide binding]; other site
700508012169	putative homodimer interface [polypeptide binding]; other site
700508012170	short chain dehydrogenase; Provisional; Region: PRK07814
700508012171	classical (c) SDRs; Region: SDR_c; cd05233
700508012172	NAD(P) binding site [chemical binding]; other site
700508012173	active site
700508012174	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
700508012175	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
700508012176	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
700508012177	putative active site pocket [active]
700508012178	dimerization interface [polypeptide binding]; other site
700508012179	putative catalytic residue [active]
700508012180	Protein of unknown function (DUF867); Region: DUF867; cl01713
700508012181	amino acid transporter; Region: 2A0306; TIGR00909
700508012182	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
700508012183	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
700508012184	active site
700508012185	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
700508012186	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508012187	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
700508012188	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508012189	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
700508012190	DNA binding residues [nucleotide binding]
700508012191	putative anti-sigmaE protein; Provisional; Region: PRK13920
700508012192	Anti-sigma-K factor rskA; Region: RskA; pfam10099
700508012193	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
700508012194	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508012195	Helix-turn-helix domain; Region: HTH_28; pfam13518
700508012196	Winged helix-turn helix; Region: HTH_29; pfam13551
700508012197	Homeodomain-like domain; Region: HTH_32; pfam13565
700508012198	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
700508012199	Integrase core domain; Region: rve; pfam00665
700508012200	Integrase core domain; Region: rve_3; pfam13683
700508012201	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
700508012202	active sites [active]
700508012203	tetramer interface [polypeptide binding]; other site
700508012204	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
700508012205	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
700508012206	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508012207	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
700508012208	acyl-activating enzyme (AAE) consensus motif; other site
700508012209	AMP binding site [chemical binding]; other site
700508012210	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508012211	Condensation domain; Region: Condensation; pfam00668
700508012212	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508012213	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700508012214	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508012215	acyl-activating enzyme (AAE) consensus motif; other site
700508012216	AMP binding site [chemical binding]; other site
700508012217	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508012218	Condensation domain; Region: Condensation; pfam00668
700508012219	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508012220	Condensation domain; Region: Condensation; pfam00668
700508012221	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508012222	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508012223	acyl-activating enzyme (AAE) consensus motif; other site
700508012224	AMP binding site [chemical binding]; other site
700508012225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508012226	S-adenosylmethionine binding site [chemical binding]; other site
700508012227	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508012228	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508012229	Condensation domain; Region: Condensation; pfam00668
700508012230	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508012231	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700508012232	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508012233	acyl-activating enzyme (AAE) consensus motif; other site
700508012234	AMP binding site [chemical binding]; other site
700508012235	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508012236	Condensation domain; Region: Condensation; pfam00668
700508012237	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508012238	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700508012239	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508012240	acyl-activating enzyme (AAE) consensus motif; other site
700508012241	AMP binding site [chemical binding]; other site
700508012242	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508012243	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
700508012244	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
700508012245	siderophore binding site; other site
700508012246	H+ Antiporter protein; Region: 2A0121; TIGR00900
700508012247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508012248	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
700508012249	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
700508012250	ABC-ATPase subunit  interface; other site
700508012251	dimer interface [polypeptide binding]; other site
700508012252	putative PBP binding regions; other site
700508012253	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
700508012254	ABC-ATPase subunit  interface; other site
700508012255	dimer interface [polypeptide binding]; other site
700508012256	putative PBP binding regions; other site
700508012257	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
700508012258	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508012259	SnoaL-like domain; Region: SnoaL_2; pfam12680
700508012260	Ecdysteroid kinase; Region: EcKinase; cl17738
700508012261	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508012262	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508012263	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
700508012264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
700508012265	MOSC domain; Region: MOSC; pfam03473
700508012266	3-alpha domain; Region: 3-alpha; pfam03475
700508012267	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
700508012268	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
700508012269	FAD binding pocket [chemical binding]; other site
700508012270	FAD binding motif [chemical binding]; other site
700508012271	phosphate binding motif [ion binding]; other site
700508012272	beta-alpha-beta structure motif; other site
700508012273	NAD binding pocket [chemical binding]; other site
700508012274	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508012275	catalytic loop [active]
700508012276	iron binding site [ion binding]; other site
700508012277	Isochorismatase family; Region: Isochorismatase; pfam00857
700508012278	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
700508012279	catalytic triad [active]
700508012280	conserved cis-peptide bond; other site
700508012281	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508012282	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
700508012283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508012284	active site
700508012285	phosphorylation site [posttranslational modification]
700508012286	intermolecular recognition site; other site
700508012287	dimerization interface [polypeptide binding]; other site
700508012288	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
700508012289	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
700508012290	CHASE3 domain; Region: CHASE3; pfam05227
700508012291	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700508012292	dimerization interface [polypeptide binding]; other site
700508012293	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508012294	dimer interface [polypeptide binding]; other site
700508012295	phosphorylation site [posttranslational modification]
700508012296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508012297	ATP binding site [chemical binding]; other site
700508012298	Mg2+ binding site [ion binding]; other site
700508012299	G-X-G motif; other site
700508012300	Response regulator receiver domain; Region: Response_reg; pfam00072
700508012301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508012302	active site
700508012303	phosphorylation site [posttranslational modification]
700508012304	intermolecular recognition site; other site
700508012305	dimerization interface [polypeptide binding]; other site
700508012306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
700508012307	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
700508012308	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
700508012309	anti sigma factor interaction site; other site
700508012310	regulatory phosphorylation site [posttranslational modification]; other site
700508012311	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516
700508012312	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
700508012313	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700508012314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508012315	dimer interface [polypeptide binding]; other site
700508012316	conserved gate region; other site
700508012317	ABC-ATPase subunit interface; other site
700508012318	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
700508012319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508012320	dimer interface [polypeptide binding]; other site
700508012321	conserved gate region; other site
700508012322	putative PBP binding loops; other site
700508012323	ABC-ATPase subunit interface; other site
700508012324	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508012325	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
700508012326	Walker A/P-loop; other site
700508012327	ATP binding site [chemical binding]; other site
700508012328	Q-loop/lid; other site
700508012329	ABC transporter signature motif; other site
700508012330	Walker B; other site
700508012331	D-loop; other site
700508012332	H-loop/switch region; other site
700508012333	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
700508012334	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508012335	Walker A/P-loop; other site
700508012336	ATP binding site [chemical binding]; other site
700508012337	Q-loop/lid; other site
700508012338	ABC transporter signature motif; other site
700508012339	Walker B; other site
700508012340	D-loop; other site
700508012341	H-loop/switch region; other site
700508012342	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
700508012343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508012344	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
700508012345	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
700508012346	DNA binding site [nucleotide binding]
700508012347	active site
700508012348	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
700508012349	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
700508012350	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
700508012351	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508012352	active site
700508012353	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
700508012354	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
700508012355	Predicted transcriptional regulators [Transcription]; Region: COG1733
700508012356	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700508012357	Predicted transcriptional regulators [Transcription]; Region: COG1733
700508012358	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700508012359	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
700508012360	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
700508012361	putative dimer interface [polypeptide binding]; other site
700508012362	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
700508012363	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
700508012364	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
700508012365	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
700508012366	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508012367	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
700508012368	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508012369	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700508012370	hydrophobic ligand binding site; other site
700508012371	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
700508012372	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
700508012373	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700508012374	Soluble P-type ATPase [General function prediction only]; Region: COG4087
700508012375	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508012376	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508012377	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
700508012378	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700508012379	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
700508012380	enoyl-CoA hydratase; Provisional; Region: PRK06688
700508012381	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508012382	substrate binding site [chemical binding]; other site
700508012383	oxyanion hole (OAH) forming residues; other site
700508012384	trimer interface [polypeptide binding]; other site
700508012385	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
700508012386	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
700508012387	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508012388	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
700508012389	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508012390	dimer interface [polypeptide binding]; other site
700508012391	phosphorylation site [posttranslational modification]
700508012392	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508012393	ATP binding site [chemical binding]; other site
700508012394	Mg2+ binding site [ion binding]; other site
700508012395	G-X-G motif; other site
700508012396	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508012397	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508012398	active site
700508012399	phosphorylation site [posttranslational modification]
700508012400	intermolecular recognition site; other site
700508012401	dimerization interface [polypeptide binding]; other site
700508012402	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508012403	DNA binding site [nucleotide binding]
700508012404	Predicted membrane protein [Function unknown]; Region: COG2259
700508012405	Predicted membrane protein [Function unknown]; Region: COG1511
700508012406	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
700508012407	Predicted membrane protein [Function unknown]; Region: COG1511
700508012408	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
700508012409	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
700508012410	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
700508012411	Rhomboid family; Region: Rhomboid; pfam01694
700508012412	AMP-binding domain protein; Validated; Region: PRK08315
700508012413	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508012414	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
700508012415	acyl-activating enzyme (AAE) consensus motif; other site
700508012416	acyl-activating enzyme (AAE) consensus motif; other site
700508012417	putative AMP binding site [chemical binding]; other site
700508012418	putative active site [active]
700508012419	putative CoA binding site [chemical binding]; other site
700508012420	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
700508012421	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508012422	acyl-activating enzyme (AAE) consensus motif; other site
700508012423	AMP binding site [chemical binding]; other site
700508012424	active site
700508012425	CoA binding site [chemical binding]; other site
700508012426	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508012427	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508012428	DNA binding residues [nucleotide binding]
700508012429	dimerization interface [polypeptide binding]; other site
700508012430	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700508012431	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700508012432	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508012433	Walker A/P-loop; other site
700508012434	ATP binding site [chemical binding]; other site
700508012435	Q-loop/lid; other site
700508012436	ABC transporter signature motif; other site
700508012437	Walker B; other site
700508012438	D-loop; other site
700508012439	H-loop/switch region; other site
700508012440	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
700508012441	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
700508012442	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508012443	Walker A/P-loop; other site
700508012444	ATP binding site [chemical binding]; other site
700508012445	Q-loop/lid; other site
700508012446	ABC transporter signature motif; other site
700508012447	Walker B; other site
700508012448	D-loop; other site
700508012449	H-loop/switch region; other site
700508012450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508012451	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508012452	active site
700508012453	phosphorylation site [posttranslational modification]
700508012454	intermolecular recognition site; other site
700508012455	dimerization interface [polypeptide binding]; other site
700508012456	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508012457	DNA binding site [nucleotide binding]
700508012458	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
700508012459	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508012460	HAMP domain; Region: HAMP; pfam00672
700508012461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508012462	dimer interface [polypeptide binding]; other site
700508012463	phosphorylation site [posttranslational modification]
700508012464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508012465	ATP binding site [chemical binding]; other site
700508012466	Mg2+ binding site [ion binding]; other site
700508012467	G-X-G motif; other site
700508012468	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
700508012469	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
700508012470	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508012471	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508012472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508012473	Major Facilitator Superfamily; Region: MFS_1; pfam07690
700508012474	putative substrate translocation pore; other site
700508012475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508012476	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
700508012477	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
700508012478	dimer interface [polypeptide binding]; other site
700508012479	active site
700508012480	citrylCoA binding site [chemical binding]; other site
700508012481	NADH binding [chemical binding]; other site
700508012482	cationic pore residues; other site
700508012483	oxalacetate/citrate binding site [chemical binding]; other site
700508012484	coenzyme A binding site [chemical binding]; other site
700508012485	catalytic triad [active]
700508012486	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508012487	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508012488	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508012489	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
700508012490	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
700508012491	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
700508012492	citrate synthase 2; Provisional; Region: PRK12350
700508012493	Citrate synthase; Region: Citrate_synt; pfam00285
700508012494	oxalacetate binding site [chemical binding]; other site
700508012495	citrylCoA binding site [chemical binding]; other site
700508012496	coenzyme A binding site [chemical binding]; other site
700508012497	catalytic triad [active]
700508012498	TIGR03086 family protein; Region: TIGR03086
700508012499	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
700508012500	putative dimer interface [polypeptide binding]; other site
700508012501	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508012502	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
700508012503	beta-galactosidase; Region: BGL; TIGR03356
700508012504	Ferredoxin [Energy production and conversion]; Region: COG1146
700508012505	4Fe-4S binding domain; Region: Fer4; pfam00037
700508012506	ferredoxin-NADP+ reductase; Region: PLN02852
700508012507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
700508012508	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
700508012509	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508012510	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508012511	catalytic residue [active]
700508012512	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
700508012513	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508012514	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508012515	active site
700508012516	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508012517	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508012518	WHG domain; Region: WHG; pfam13305
700508012519	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
700508012520	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
700508012521	homodimer interface [polypeptide binding]; other site
700508012522	active site
700508012523	TDP-binding site; other site
700508012524	acceptor substrate-binding pocket; other site
700508012525	Part of AAA domain; Region: AAA_19; pfam13245
700508012526	Family description; Region: UvrD_C_2; pfam13538
700508012527	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
700508012528	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
700508012529	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700508012530	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
700508012531	MarR family; Region: MarR; pfam01047
700508012532	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
700508012533	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
700508012534	hydrophobic ligand binding site; other site
700508012535	H+ Antiporter protein; Region: 2A0121; TIGR00900
700508012536	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
700508012537	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
700508012538	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
700508012539	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
700508012540	putative dimer interface [polypeptide binding]; other site
700508012541	N-terminal domain interface [polypeptide binding]; other site
700508012542	putative substrate binding pocket (H-site) [chemical binding]; other site
700508012543	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
700508012544	DNA-binding site [nucleotide binding]; DNA binding site
700508012545	RNA-binding motif; other site
700508012546	hypothetical protein; Provisional; Region: PRK11770
700508012547	Domain of unknown function (DUF307); Region: DUF307; pfam03733
700508012548	Domain of unknown function (DUF307); Region: DUF307; pfam03733
700508012549	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
700508012550	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508012551	FeS/SAM binding site; other site
700508012552	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
700508012553	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
700508012554	MoaE interaction surface [polypeptide binding]; other site
700508012555	MoeB interaction surface [polypeptide binding]; other site
700508012556	thiocarboxylated glycine; other site
700508012557	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
700508012558	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
700508012559	MoaD interaction [polypeptide binding]; other site
700508012560	active site residues [active]
700508012561	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
700508012562	MPT binding site; other site
700508012563	trimer interface [polypeptide binding]; other site
700508012564	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
700508012565	trimer interface [polypeptide binding]; other site
700508012566	dimer interface [polypeptide binding]; other site
700508012567	putative active site [active]
700508012568	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
700508012569	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
700508012570	active site
700508012571	metal binding site [ion binding]; metal-binding site
700508012572	Cupin domain; Region: Cupin_2; cl17218
700508012573	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508012574	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
700508012575	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
700508012576	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
700508012577	metal binding site [ion binding]; metal-binding site
700508012578	active site
700508012579	I-site; other site
700508012580	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
700508012581	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
700508012582	conserved cys residue [active]
700508012583	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508012584	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
700508012585	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508012586	substrate binding site [chemical binding]; other site
700508012587	oxyanion hole (OAH) forming residues; other site
700508012588	trimer interface [polypeptide binding]; other site
700508012589	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
700508012590	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
700508012591	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
700508012592	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508012593	dimer interface [polypeptide binding]; other site
700508012594	active site
700508012595	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700508012596	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
700508012597	FMN binding site [chemical binding]; other site
700508012598	active site
700508012599	substrate binding site [chemical binding]; other site
700508012600	catalytic residue [active]
700508012601	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508012602	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508012603	DNA binding residues [nucleotide binding]
700508012604	dimerization interface [polypeptide binding]; other site
700508012605	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700508012606	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
700508012607	putative ligand binding site [chemical binding]; other site
700508012608	bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192
700508012609	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
700508012610	alpha-gamma subunit interface [polypeptide binding]; other site
700508012611	beta-gamma subunit interface [polypeptide binding]; other site
700508012612	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
700508012613	alpha-beta subunit interface [polypeptide binding]; other site
700508012614	urease subunit alpha; Reviewed; Region: ureC; PRK13308
700508012615	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
700508012616	subunit interactions [polypeptide binding]; other site
700508012617	active site
700508012618	flap region; other site
700508012619	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700508012620	UreD urease accessory protein; Region: UreD; pfam01774
700508012621	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
700508012622	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727
700508012623	dimer interface [polypeptide binding]; other site
700508012624	catalytic residues [active]
700508012625	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
700508012626	UreF; Region: UreF; pfam01730
700508012627	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
700508012628	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
700508012629	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
700508012630	NAD binding site [chemical binding]; other site
700508012631	catalytic Zn binding site [ion binding]; other site
700508012632	substrate binding site [chemical binding]; other site
700508012633	structural Zn binding site [ion binding]; other site
700508012634	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
700508012635	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
700508012636	NmrA-like family; Region: NmrA; pfam05368
700508012637	NADP binding site [chemical binding]; other site
700508012638	active site
700508012639	regulatory binding site [polypeptide binding]; other site
700508012640	aminotransferase; Validated; Region: PRK07777
700508012641	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508012642	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508012643	homodimer interface [polypeptide binding]; other site
700508012644	catalytic residue [active]
700508012645	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
700508012646	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
700508012647	Na binding site [ion binding]; other site
700508012648	putative substrate binding site [chemical binding]; other site
700508012649	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
700508012650	Transcriptional regulators [Transcription]; Region: GntR; COG1802
700508012651	DNA-binding site [nucleotide binding]; DNA binding site
700508012652	FCD domain; Region: FCD; pfam07729
700508012653	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
700508012654	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508012655	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
700508012656	putative hydrophobic ligand binding site [chemical binding]; other site
700508012657	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
700508012658	CoA-transferase family III; Region: CoA_transf_3; pfam02515
700508012659	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
700508012660	putative hydrophobic ligand binding site [chemical binding]; other site
700508012661	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012662	mce related protein; Region: MCE; pfam02470
700508012663	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012664	mce related protein; Region: MCE; pfam02470
700508012665	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508012666	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012667	mce related protein; Region: MCE; pfam02470
700508012668	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012669	mce related protein; Region: MCE; pfam02470
700508012670	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
700508012671	mce related protein; Region: MCE; pfam02470
700508012672	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012673	mce related protein; Region: MCE; pfam02470
700508012674	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508012675	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508012676	Permease; Region: Permease; pfam02405
700508012677	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508012678	Permease; Region: Permease; pfam02405
700508012679	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
700508012680	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
700508012681	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508012682	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508012683	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508012684	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508012685	Uncharacterized conserved protein [Function unknown]; Region: COG1434
700508012686	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
700508012687	putative active site [active]
700508012688	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508012689	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508012690	active site
700508012691	ATP binding site [chemical binding]; other site
700508012692	substrate binding site [chemical binding]; other site
700508012693	activation loop (A-loop); other site
700508012694	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
700508012695	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
700508012696	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
700508012697	homodimer interface [polypeptide binding]; other site
700508012698	putative substrate binding pocket [chemical binding]; other site
700508012699	diiron center [ion binding]; other site
700508012700	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
700508012701	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
700508012702	FMN binding site [chemical binding]; other site
700508012703	active site
700508012704	catalytic residues [active]
700508012705	substrate binding site [chemical binding]; other site
700508012706	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
700508012707	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
700508012708	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
700508012709	PhoU domain; Region: PhoU; pfam01895
700508012710	PhoU domain; Region: PhoU; pfam01895
700508012711	MarR family; Region: MarR_2; cl17246
700508012712	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
700508012713	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
700508012714	putative NAD(P) binding site [chemical binding]; other site
700508012715	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
700508012716	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
700508012717	Walker A/P-loop; other site
700508012718	ATP binding site [chemical binding]; other site
700508012719	Q-loop/lid; other site
700508012720	ABC transporter signature motif; other site
700508012721	Walker B; other site
700508012722	D-loop; other site
700508012723	H-loop/switch region; other site
700508012724	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
700508012725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508012726	dimer interface [polypeptide binding]; other site
700508012727	conserved gate region; other site
700508012728	putative PBP binding loops; other site
700508012729	ABC-ATPase subunit interface; other site
700508012730	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
700508012731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508012732	dimer interface [polypeptide binding]; other site
700508012733	conserved gate region; other site
700508012734	putative PBP binding loops; other site
700508012735	ABC-ATPase subunit interface; other site
700508012736	PBP superfamily domain; Region: PBP_like_2; cl17296
700508012737	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
700508012738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508012739	Coenzyme A binding pocket [chemical binding]; other site
700508012740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
700508012741	Coenzyme A binding pocket [chemical binding]; other site
700508012742	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508012743	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508012744	DNA binding site [nucleotide binding]
700508012745	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
700508012746	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
700508012747	catalytic residues [active]
700508012748	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
700508012749	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
700508012750	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
700508012751	active site residue [active]
700508012752	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
700508012753	active site residue [active]
700508012754	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
700508012755	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
700508012756	heme-binding site [chemical binding]; other site
700508012757	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
700508012758	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
700508012759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508012760	catalytic residue [active]
700508012761	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
700508012762	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
700508012763	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
700508012764	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
700508012765	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
700508012766	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
700508012767	dimerization interface [polypeptide binding]; other site
700508012768	putative ATP binding site [chemical binding]; other site
700508012769	Cupin domain; Region: Cupin_2; pfam07883
700508012770	amidophosphoribosyltransferase; Provisional; Region: PRK07847
700508012771	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
700508012772	active site
700508012773	tetramer interface [polypeptide binding]; other site
700508012774	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700508012775	active site
700508012776	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012777	mce related protein; Region: MCE; pfam02470
700508012778	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508012779	Predicted membrane protein [Function unknown]; Region: COG4425
700508012780	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
700508012781	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
700508012782	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
700508012783	dimerization interface [polypeptide binding]; other site
700508012784	ATP binding site [chemical binding]; other site
700508012785	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
700508012786	dimerization interface [polypeptide binding]; other site
700508012787	ATP binding site [chemical binding]; other site
700508012788	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
700508012789	active site
700508012790	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
700508012791	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
700508012792	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
700508012793	active site
700508012794	metal binding site [ion binding]; metal-binding site
700508012795	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
700508012796	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
700508012797	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
700508012798	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
700508012799	putative active site [active]
700508012800	catalytic triad [active]
700508012801	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
700508012802	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700508012803	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
700508012804	PAP2 superfamily; Region: PAP2; pfam01569
700508012805	active site
700508012806	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
700508012807	FAD binding domain; Region: FAD_binding_2; pfam00890
700508012808	Predicted deacetylase [General function prediction only]; Region: COG3233
700508012809	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
700508012810	putative active site [active]
700508012811	putative Zn binding site [ion binding]; other site
700508012812	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
700508012813	catalytic residues [active]
700508012814	dimer interface [polypeptide binding]; other site
700508012815	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
700508012816	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
700508012817	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
700508012818	ATP binding site [chemical binding]; other site
700508012819	active site
700508012820	substrate binding site [chemical binding]; other site
700508012821	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
700508012822	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
700508012823	ABC-ATPase subunit  interface; other site
700508012824	dimer interface [polypeptide binding]; other site
700508012825	putative PBP binding regions; other site
700508012826	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
700508012827	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
700508012828	ABC-ATPase subunit  interface; other site
700508012829	dimer interface [polypeptide binding]; other site
700508012830	putative PBP binding regions; other site
700508012831	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
700508012832	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
700508012833	Walker A/P-loop; other site
700508012834	ATP binding site [chemical binding]; other site
700508012835	Q-loop/lid; other site
700508012836	ABC transporter signature motif; other site
700508012837	Walker B; other site
700508012838	D-loop; other site
700508012839	H-loop/switch region; other site
700508012840	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
700508012841	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
700508012842	siderophore binding site; other site
700508012843	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
700508012844	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508012845	Cytochrome P450; Region: p450; cl12078
700508012846	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
700508012847	Lyase; Region: Lyase_1; pfam00206
700508012848	tetramer interface [polypeptide binding]; other site
700508012849	amino acid transporter; Region: 2A0306; TIGR00909
700508012850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
700508012851	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
700508012852	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
700508012853	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
700508012854	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
700508012855	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508012856	Cytochrome P450; Region: p450; cl12078
700508012857	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508012858	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
700508012859	DNA-binding interface [nucleotide binding]; DNA binding site
700508012860	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
700508012861	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
700508012862	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
700508012863	short chain dehydrogenase; Provisional; Region: PRK07774
700508012864	classical (c) SDRs; Region: SDR_c; cd05233
700508012865	NAD(P) binding site [chemical binding]; other site
700508012866	active site
700508012867	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
700508012868	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
700508012869	NAD binding site [chemical binding]; other site
700508012870	catalytic residues [active]
700508012871	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508012872	Cytochrome P450; Region: p450; cl12078
700508012873	short chain dehydrogenase; Provisional; Region: PRK07775
700508012874	classical (c) SDRs; Region: SDR_c; cd05233
700508012875	NAD(P) binding site [chemical binding]; other site
700508012876	active site
700508012877	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508012878	Cytochrome P450; Region: p450; cl12078
700508012879	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
700508012880	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
700508012881	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
700508012882	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
700508012883	NAD binding site [chemical binding]; other site
700508012884	catalytic Zn binding site [ion binding]; other site
700508012885	substrate binding site [chemical binding]; other site
700508012886	structural Zn binding site [ion binding]; other site
700508012887	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700508012888	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
700508012889	classical (c) SDRs; Region: SDR_c; cd05233
700508012890	NAD(P) binding site [chemical binding]; other site
700508012891	active site
700508012892	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
700508012893	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
700508012894	dimer interface [polypeptide binding]; other site
700508012895	acyl-activating enzyme (AAE) consensus motif; other site
700508012896	putative active site [active]
700508012897	AMP binding site [chemical binding]; other site
700508012898	putative CoA binding site [chemical binding]; other site
700508012899	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
700508012900	nucleotide binding site/active site [active]
700508012901	HIT family signature motif; other site
700508012902	catalytic residue [active]
700508012903	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508012904	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700508012905	dimerization interface [polypeptide binding]; other site
700508012906	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
700508012907	dimer interface [polypeptide binding]; other site
700508012908	phosphorylation site [posttranslational modification]
700508012909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508012910	ATP binding site [chemical binding]; other site
700508012911	Mg2+ binding site [ion binding]; other site
700508012912	G-X-G motif; other site
700508012913	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508012914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508012915	active site
700508012916	phosphorylation site [posttranslational modification]
700508012917	intermolecular recognition site; other site
700508012918	dimerization interface [polypeptide binding]; other site
700508012919	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508012920	DNA binding site [nucleotide binding]
700508012921	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
700508012922	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
700508012923	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
700508012924	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
700508012925	XdhC Rossmann domain; Region: XdhC_C; pfam13478
700508012926	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508012927	short chain dehydrogenase; Provisional; Region: PRK05875
700508012928	classical (c) SDRs; Region: SDR_c; cd05233
700508012929	NAD(P) binding site [chemical binding]; other site
700508012930	active site
700508012931	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
700508012932	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
700508012933	active site
700508012934	homotetramer interface [polypeptide binding]; other site
700508012935	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012936	mce related protein; Region: MCE; pfam02470
700508012937	Tellurite resistance protein TerB; Region: TerB; cl17311
700508012938	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012939	mce related protein; Region: MCE; pfam02470
700508012940	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508012941	mce related protein; Region: MCE; pfam02470
700508012942	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508012943	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
700508012944	mce related protein; Region: MCE; pfam02470
700508012945	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
700508012946	mce related protein; Region: MCE; pfam02470
700508012947	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508012948	mce related protein; Region: MCE; pfam02470
700508012949	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
700508012950	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
700508012951	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508012952	acyl-activating enzyme (AAE) consensus motif; other site
700508012953	AMP binding site [chemical binding]; other site
700508012954	active site
700508012955	CoA binding site [chemical binding]; other site
700508012956	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
700508012957	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
700508012958	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
700508012959	putative NAD(P) binding site [chemical binding]; other site
700508012960	active site
700508012961	putative substrate binding site [chemical binding]; other site
700508012962	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508012963	Cytochrome P450; Region: p450; cl12078
700508012964	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508012965	Cytochrome P450; Region: p450; cl12078
700508012966	Domain of unknown function (DUF385); Region: DUF385; cl04387
700508012967	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
700508012968	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
700508012969	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508012970	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
700508012971	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508012972	catalytic residue [active]
700508012973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508012974	NAD(P) binding site [chemical binding]; other site
700508012975	active site
700508012976	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
700508012977	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
700508012978	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508012979	Permease; Region: Permease; pfam02405
700508012980	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
700508012981	Permease; Region: Permease; pfam02405
700508012982	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
700508012983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508012984	NAD(P) binding site [chemical binding]; other site
700508012985	active site
700508012986	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508012987	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
700508012988	FAD binding site [chemical binding]; other site
700508012989	substrate binding site [chemical binding]; other site
700508012990	catalytic base [active]
700508012991	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508012992	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
700508012993	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
700508012994	active site
700508012995	acyl-CoA synthetase; Validated; Region: PRK07867
700508012996	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508012997	acyl-activating enzyme (AAE) consensus motif; other site
700508012998	AMP binding site [chemical binding]; other site
700508012999	active site
700508013000	CoA binding site [chemical binding]; other site
700508013001	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
700508013002	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
700508013003	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
700508013004	active site
700508013005	FMN binding site [chemical binding]; other site
700508013006	substrate binding site [chemical binding]; other site
700508013007	putative catalytic residue [active]
700508013008	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508013009	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
700508013010	NAD(P) binding site [chemical binding]; other site
700508013011	active site
700508013012	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508013013	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508013014	Nitronate monooxygenase; Region: NMO; pfam03060
700508013015	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700508013016	FMN binding site [chemical binding]; other site
700508013017	substrate binding site [chemical binding]; other site
700508013018	putative catalytic residue [active]
700508013019	acyl-CoA synthetase; Validated; Region: PRK07798
700508013020	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508013021	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
700508013022	acyl-activating enzyme (AAE) consensus motif; other site
700508013023	acyl-activating enzyme (AAE) consensus motif; other site
700508013024	putative AMP binding site [chemical binding]; other site
700508013025	putative active site [active]
700508013026	putative CoA binding site [chemical binding]; other site
700508013027	enoyl-CoA hydratase; Provisional; Region: PRK07799
700508013028	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508013029	substrate binding site [chemical binding]; other site
700508013030	oxyanion hole (OAH) forming residues; other site
700508013031	trimer interface [polypeptide binding]; other site
700508013032	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
700508013033	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
700508013034	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
700508013035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508013036	putative substrate translocation pore; other site
700508013037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
700508013038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
700508013039	phosphorylation site [posttranslational modification]
700508013040	dimer interface [polypeptide binding]; other site
700508013041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
700508013042	ATP binding site [chemical binding]; other site
700508013043	Mg2+ binding site [ion binding]; other site
700508013044	G-X-G motif; other site
700508013045	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
700508013046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508013047	active site
700508013048	phosphorylation site [posttranslational modification]
700508013049	intermolecular recognition site; other site
700508013050	dimerization interface [polypeptide binding]; other site
700508013051	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
700508013052	DNA binding site [nucleotide binding]
700508013053	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508013054	Cytochrome P450; Region: p450; cl12078
700508013055	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
700508013056	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508013057	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
700508013058	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
700508013059	DUF35 OB-fold domain; Region: DUF35; pfam01796
700508013060	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
700508013061	DUF35 OB-fold domain; Region: DUF35; pfam01796
700508013062	lipid-transfer protein; Provisional; Region: PRK07937
700508013063	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508013064	active site
700508013065	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
700508013066	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508013067	active site
700508013068	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700508013069	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
700508013070	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
700508013071	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
700508013072	short chain dehydrogenase; Provisional; Region: PRK07890
700508013073	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508013074	NAD(P) binding site [chemical binding]; other site
700508013075	active site
700508013076	Transcriptional regulator [Transcription]; Region: IclR; COG1414
700508013077	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
700508013078	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
700508013079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508013080	ATP binding site [chemical binding]; other site
700508013081	putative Mg++ binding site [ion binding]; other site
700508013082	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508013083	nucleotide binding region [chemical binding]; other site
700508013084	ATP-binding site [chemical binding]; other site
700508013085	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
700508013086	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
700508013087	MarR family; Region: MarR_2; pfam12802
700508013088	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
700508013089	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
700508013090	hypothetical protein; Validated; Region: PRK07581
700508013091	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
700508013092	putative hydrophobic ligand binding site [chemical binding]; other site
700508013093	protein interface [polypeptide binding]; other site
700508013094	gate; other site
700508013095	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
700508013096	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
700508013097	active site
700508013098	catalytic residues [active]
700508013099	metal binding site [ion binding]; metal-binding site
700508013100	DmpG-like communication domain; Region: DmpG_comm; pfam07836
700508013101	acetaldehyde dehydrogenase; Validated; Region: PRK08300
700508013102	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
700508013103	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
700508013104	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
700508013105	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
700508013106	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
700508013107	enoyl-CoA hydratase; Region: PLN02864
700508013108	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
700508013109	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
700508013110	dimer interaction site [polypeptide binding]; other site
700508013111	substrate-binding tunnel; other site
700508013112	active site
700508013113	catalytic site [active]
700508013114	substrate binding site [chemical binding]; other site
700508013115	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
700508013116	GAF domain; Region: GAF; pfam01590
700508013117	ANTAR domain; Region: ANTAR; pfam03861
700508013118	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
700508013119	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
700508013120	putative active site [active]
700508013121	Thioesterase domain; Region: Thioesterase; pfam00975
700508013122	Condensation domain; Region: Condensation; pfam00668
700508013123	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508013124	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
700508013125	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508013126	acyl-activating enzyme (AAE) consensus motif; other site
700508013127	AMP binding site [chemical binding]; other site
700508013128	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508013129	Condensation domain; Region: Condensation; pfam00668
700508013130	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
700508013131	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508013132	acyl-activating enzyme (AAE) consensus motif; other site
700508013133	AMP binding site [chemical binding]; other site
700508013134	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508013135	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
700508013136	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
700508013137	active site
700508013138	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
700508013139	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
700508013140	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508013141	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
700508013142	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508013143	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508013144	catalytic residue [active]
700508013145	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
700508013146	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
700508013147	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
700508013148	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
700508013149	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700508013150	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
700508013151	NAD binding site [chemical binding]; other site
700508013152	putative substrate binding site 2 [chemical binding]; other site
700508013153	putative substrate binding site 1 [chemical binding]; other site
700508013154	active site
700508013155	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
700508013156	Bacterial sugar transferase; Region: Bac_transf; pfam02397
700508013157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
700508013158	FeS/SAM binding site; other site
700508013159	Radical SAM superfamily; Region: Radical_SAM; pfam04055
700508013160	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
700508013161	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
700508013162	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
700508013163	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
700508013164	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
700508013165	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
700508013166	putative active site [active]
700508013167	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508013168	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
700508013169	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
700508013170	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
700508013171	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
700508013172	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
700508013173	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
700508013174	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
700508013175	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700508013176	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508013177	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700508013178	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
700508013179	putative NAD(P) binding site [chemical binding]; other site
700508013180	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
700508013181	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
700508013182	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
700508013183	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508013184	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700508013185	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
700508013186	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
700508013187	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
700508013188	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
700508013189	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508013190	NAD(P) binding site [chemical binding]; other site
700508013191	active site
700508013192	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
700508013193	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
700508013194	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
700508013195	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
700508013196	acyl-activating enzyme (AAE) consensus motif; other site
700508013197	AMP binding site [chemical binding]; other site
700508013198	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
700508013199	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
700508013200	glutaminase active site [active]
700508013201	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
700508013202	dimer interface [polypeptide binding]; other site
700508013203	active site
700508013204	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
700508013205	dimer interface [polypeptide binding]; other site
700508013206	active site
700508013207	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508013208	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508013209	DNA binding residues [nucleotide binding]
700508013210	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508013211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508013212	active site
700508013213	intermolecular recognition site; other site
700508013214	dimerization interface [polypeptide binding]; other site
700508013215	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508013216	DNA binding residues [nucleotide binding]
700508013217	dimerization interface [polypeptide binding]; other site
700508013218	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
700508013219	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
700508013220	lipid-transfer protein; Provisional; Region: PRK07855
700508013221	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
700508013222	active site
700508013223	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
700508013224	putative active site [active]
700508013225	putative catalytic site [active]
700508013226	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
700508013227	active site
700508013228	catalytic site [active]
700508013229	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
700508013230	DUF35 OB-fold domain; Region: DUF35; pfam01796
700508013231	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013232	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013233	active site
700508013234	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013235	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013236	active site
700508013237	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
700508013238	Cytochrome P450; Region: p450; cl12078
700508013239	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
700508013240	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508013241	dimer interface [polypeptide binding]; other site
700508013242	active site
700508013243	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
700508013244	Domain of unknown function (DUF385); Region: DUF385; pfam04075
700508013245	short chain dehydrogenase; Provisional; Region: PRK07791
700508013246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508013247	NAD(P) binding site [chemical binding]; other site
700508013248	active site
700508013249	short chain dehydrogenase; Provisional; Region: PRK07856
700508013250	classical (c) SDRs; Region: SDR_c; cd05233
700508013251	NAD(P) binding site [chemical binding]; other site
700508013252	active site
700508013253	enoyl-CoA hydratase; Provisional; Region: PRK06495
700508013254	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
700508013255	substrate binding site [chemical binding]; other site
700508013256	oxyanion hole (OAH) forming residues; other site
700508013257	trimer interface [polypeptide binding]; other site
700508013258	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
700508013259	Coenzyme A transferase; Region: CoA_trans; cl17247
700508013260	Nitronate monooxygenase; Region: NMO; pfam03060
700508013261	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
700508013262	FMN binding site [chemical binding]; other site
700508013263	substrate binding site [chemical binding]; other site
700508013264	putative catalytic residue [active]
700508013265	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
700508013266	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
700508013267	NAD binding site [chemical binding]; other site
700508013268	catalytic Zn binding site [ion binding]; other site
700508013269	substrate binding site [chemical binding]; other site
700508013270	structural Zn binding site [ion binding]; other site
700508013271	xanthine permease; Region: pbuX; TIGR03173
700508013272	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
700508013273	putative OHCU decarboxylase; Provisional; Region: PRK13798
700508013274	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
700508013275	active site
700508013276	homotetramer interface [polypeptide binding]; other site
700508013277	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
700508013278	hypothetical protein; Provisional; Region: PRK07236
700508013279	guanine deaminase; Provisional; Region: PRK09228
700508013280	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
700508013281	active site
700508013282	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
700508013283	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
700508013284	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508013285	catalytic loop [active]
700508013286	iron binding site [ion binding]; other site
700508013287	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
700508013288	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
700508013289	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
700508013290	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
700508013291	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
700508013292	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
700508013293	dimer interface [polypeptide binding]; other site
700508013294	active site
700508013295	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508013296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508013297	short chain dehydrogenase; Provisional; Region: PRK07831
700508013298	classical (c) SDRs; Region: SDR_c; cd05233
700508013299	NAD(P) binding site [chemical binding]; other site
700508013300	active site
700508013301	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013302	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013303	active site
700508013304	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
700508013305	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
700508013306	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
700508013307	acyl-activating enzyme (AAE) consensus motif; other site
700508013308	putative AMP binding site [chemical binding]; other site
700508013309	putative active site [active]
700508013310	putative CoA binding site [chemical binding]; other site
700508013311	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013312	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013313	active site
700508013314	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013315	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013316	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
700508013317	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013318	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013319	active site
700508013320	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
700508013321	catalytic triad [active]
700508013322	conserved cis-peptide bond; other site
700508013323	aspartate aminotransferase; Provisional; Region: PRK05764
700508013324	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
700508013325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508013326	homodimer interface [polypeptide binding]; other site
700508013327	catalytic residue [active]
700508013328	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508013329	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508013330	active site
700508013331	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508013332	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508013333	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
700508013334	D-xylulose kinase; Region: XylB; TIGR01312
700508013335	nucleotide binding site [chemical binding]; other site
700508013336	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
700508013337	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
700508013338	acyl-activating enzyme (AAE) consensus motif; other site
700508013339	putative AMP binding site [chemical binding]; other site
700508013340	putative active site [active]
700508013341	putative CoA binding site [chemical binding]; other site
700508013342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508013343	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
700508013344	NAD(P) binding site [chemical binding]; other site
700508013345	active site
700508013346	metabolite-proton symporter; Region: 2A0106; TIGR00883
700508013347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508013348	putative substrate translocation pore; other site
700508013349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
700508013350	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508013351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
700508013352	dimerization interface [polypeptide binding]; other site
700508013353	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
700508013354	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
700508013355	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
700508013356	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
700508013357	active site
700508013358	Fe binding site [ion binding]; other site
700508013359	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
700508013360	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
700508013361	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013362	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
700508013363	Flavin binding site [chemical binding]; other site
700508013364	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
700508013365	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
700508013366	FAD binding pocket [chemical binding]; other site
700508013367	FAD binding motif [chemical binding]; other site
700508013368	phosphate binding motif [ion binding]; other site
700508013369	NAD(p) ribose binding residues [chemical binding]; other site
700508013370	beta-alpha-beta structure motif; other site
700508013371	NAD binding pocket [chemical binding]; other site
700508013372	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
700508013373	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
700508013374	catalytic loop [active]
700508013375	iron binding site [ion binding]; other site
700508013376	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013377	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
700508013378	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013379	active site
700508013380	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013381	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013382	active site
700508013383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508013384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508013385	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
700508013386	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
700508013387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
700508013388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508013389	S-adenosylmethionine binding site [chemical binding]; other site
700508013390	Transcriptional regulators [Transcription]; Region: PurR; COG1609
700508013391	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
700508013392	DNA binding site [nucleotide binding]
700508013393	domain linker motif; other site
700508013394	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
700508013395	putative dimerization interface [polypeptide binding]; other site
700508013396	putative ligand binding site [chemical binding]; other site
700508013397	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
700508013398	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
700508013399	ABC-ATPase subunit  interface; other site
700508013400	dimer interface [polypeptide binding]; other site
700508013401	putative PBP binding regions; other site
700508013402	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
700508013403	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
700508013404	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
700508013405	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
700508013406	intersubunit interface [polypeptide binding]; other site
700508013407	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
700508013408	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
700508013409	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
700508013410	PQQ-like domain; Region: PQQ_2; pfam13360
700508013411	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
700508013412	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
700508013413	intersubunit interface [polypeptide binding]; other site
700508013414	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
700508013415	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
700508013416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
700508013417	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
700508013418	Walker A/P-loop; other site
700508013419	ATP binding site [chemical binding]; other site
700508013420	Q-loop/lid; other site
700508013421	ABC transporter signature motif; other site
700508013422	Walker B; other site
700508013423	D-loop; other site
700508013424	H-loop/switch region; other site
700508013425	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
700508013426	putative active site [active]
700508013427	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
700508013428	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
700508013429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
700508013430	motif II; other site
700508013431	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
700508013432	Predicted permease; Region: DUF318; cl17795
700508013433	TIGR03943 family protein; Region: TIGR03943
700508013434	Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640
700508013435	putative DNA binding site [nucleotide binding]; other site
700508013436	putative Zn2+ binding site [ion binding]; other site
700508013437	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
700508013438	putative FMN binding site [chemical binding]; other site
700508013439	30S ribosomal protein S18; Provisional; Region: PRK13401
700508013440	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
700508013441	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
700508013442	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
700508013443	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
700508013444	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
700508013445	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
700508013446	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
700508013447	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
700508013448	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
700508013449	transmembrane helices; other site
700508013450	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
700508013451	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
700508013452	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
700508013453	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
700508013454	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
700508013455	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
700508013456	active site
700508013457	HIGH motif; other site
700508013458	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
700508013459	KMSKS motif; other site
700508013460	This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
700508013461	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084
700508013462	homotrimer interaction site [polypeptide binding]; other site
700508013463	zinc binding site [ion binding]; other site
700508013464	CDP-binding sites; other site
700508013465	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
700508013466	DNA repair protein RadA; Provisional; Region: PRK11823
700508013467	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
700508013468	Walker A motif/ATP binding site; other site
700508013469	ATP binding site [chemical binding]; other site
700508013470	Walker B motif; other site
700508013471	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
700508013472	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
700508013473	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
700508013474	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
700508013475	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
700508013476	active site clefts [active]
700508013477	zinc binding site [ion binding]; other site
700508013478	dimer interface [polypeptide binding]; other site
700508013479	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
700508013480	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700508013481	minor groove reading motif; other site
700508013482	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
700508013483	helix-hairpin-helix signature motif; other site
700508013484	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
700508013485	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
700508013486	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
700508013487	conserved cys residue [active]
700508013488	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
700508013489	Lipase (class 2); Region: Lipase_2; pfam01674
700508013490	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
700508013491	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
700508013492	catalytic site [active]
700508013493	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
700508013494	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
700508013495	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
700508013496	catalytic core [active]
700508013497	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
700508013498	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
700508013499	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
700508013500	Clp amino terminal domain; Region: Clp_N; pfam02861
700508013501	Clp amino terminal domain; Region: Clp_N; pfam02861
700508013502	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508013503	Walker A motif; other site
700508013504	ATP binding site [chemical binding]; other site
700508013505	Walker B motif; other site
700508013506	arginine finger; other site
700508013507	UvrB/uvrC motif; Region: UVR; pfam02151
700508013508	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508013509	Walker A motif; other site
700508013510	ATP binding site [chemical binding]; other site
700508013511	Walker B motif; other site
700508013512	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
700508013513	Lsr2; Region: Lsr2; pfam11774
700508013514	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
700508013515	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
700508013516	dimer interface [polypeptide binding]; other site
700508013517	putative anticodon binding site; other site
700508013518	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
700508013519	motif 1; other site
700508013520	dimer interface [polypeptide binding]; other site
700508013521	active site
700508013522	motif 2; other site
700508013523	motif 3; other site
700508013524	pantothenate kinase; Reviewed; Region: PRK13318
700508013525	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
700508013526	tetramerization interface [polypeptide binding]; other site
700508013527	active site
700508013528	Pantoate-beta-alanine ligase; Region: PanC; cd00560
700508013529	pantoate--beta-alanine ligase; Region: panC; TIGR00018
700508013530	active site
700508013531	ATP-binding site [chemical binding]; other site
700508013532	pantoate-binding site; other site
700508013533	HXXH motif; other site
700508013534	Uncharacterized conserved protein [Function unknown]; Region: COG5495
700508013535	Rossmann-like domain; Region: Rossmann-like; pfam10727
700508013536	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
700508013537	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
700508013538	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
700508013539	catalytic center binding site [active]
700508013540	ATP binding site [chemical binding]; other site
700508013541	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
700508013542	homooctamer interface [polypeptide binding]; other site
700508013543	active site
700508013544	dihydropteroate synthase; Region: DHPS; TIGR01496
700508013545	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
700508013546	substrate binding pocket [chemical binding]; other site
700508013547	dimer interface [polypeptide binding]; other site
700508013548	inhibitor binding site; inhibition site
700508013549	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
700508013550	GTP cyclohydrolase I; Provisional; Region: PLN03044
700508013551	homodecamer interface [polypeptide binding]; other site
700508013552	active site
700508013553	putative catalytic site residues [active]
700508013554	zinc binding site [ion binding]; other site
700508013555	GTP-CH-I/GFRP interaction surface; other site
700508013556	FtsH Extracellular; Region: FtsH_ext; pfam06480
700508013557	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
700508013558	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508013559	Walker A motif; other site
700508013560	ATP binding site [chemical binding]; other site
700508013561	Walker B motif; other site
700508013562	arginine finger; other site
700508013563	Peptidase family M41; Region: Peptidase_M41; pfam01434
700508013564	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508013565	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
700508013566	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
700508013567	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
700508013568	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
700508013569	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700508013570	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
700508013571	putative NAD(P) binding site [chemical binding]; other site
700508013572	catalytic Zn binding site [ion binding]; other site
700508013573	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
700508013574	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
700508013575	active site
700508013576	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
700508013577	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
700508013578	Ligand Binding Site [chemical binding]; other site
700508013579	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
700508013580	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
700508013581	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
700508013582	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
700508013583	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
700508013584	dimer interface [polypeptide binding]; other site
700508013585	substrate binding site [chemical binding]; other site
700508013586	metal binding sites [ion binding]; metal-binding site
700508013587	putative OHCU decarboxylase; Provisional; Region: PRK13798
700508013588	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
700508013589	Beta-lactamase; Region: Beta-lactamase; pfam00144
700508013590	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165
700508013591	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
700508013592	putative ligand binding site [chemical binding]; other site
700508013593	NAD binding site [chemical binding]; other site
700508013594	dimer interface [polypeptide binding]; other site
700508013595	putative catalytic site [active]
700508013596	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
700508013597	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
700508013598	active site
700508013599	tetramer interface [polypeptide binding]; other site
700508013600	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
700508013601	Transcriptional regulator [Transcription]; Region: IclR; COG1414
700508013602	Bacterial transcriptional regulator; Region: IclR; pfam01614
700508013603	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
700508013604	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
700508013605	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508013606	Walker A/P-loop; other site
700508013607	ATP binding site [chemical binding]; other site
700508013608	Q-loop/lid; other site
700508013609	ABC transporter signature motif; other site
700508013610	Walker B; other site
700508013611	D-loop; other site
700508013612	H-loop/switch region; other site
700508013613	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
700508013614	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
700508013615	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
700508013616	Walker A/P-loop; other site
700508013617	ATP binding site [chemical binding]; other site
700508013618	Q-loop/lid; other site
700508013619	ABC transporter signature motif; other site
700508013620	Walker B; other site
700508013621	D-loop; other site
700508013622	H-loop/switch region; other site
700508013623	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
700508013624	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
700508013625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508013626	dimer interface [polypeptide binding]; other site
700508013627	conserved gate region; other site
700508013628	putative PBP binding loops; other site
700508013629	ABC-ATPase subunit interface; other site
700508013630	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
700508013631	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508013632	dimer interface [polypeptide binding]; other site
700508013633	conserved gate region; other site
700508013634	putative PBP binding loops; other site
700508013635	ABC-ATPase subunit interface; other site
700508013636	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
700508013637	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491
700508013638	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
700508013639	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
700508013640	putative ligand binding site [chemical binding]; other site
700508013641	NAD binding site [chemical binding]; other site
700508013642	catalytic site [active]
700508013643	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
700508013644	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
700508013645	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
700508013646	putative dimerization interface [polypeptide binding]; other site
700508013647	putative substrate binding pocket [chemical binding]; other site
700508013648	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
700508013649	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508013650	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508013651	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
700508013652	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
700508013653	active site
700508013654	tetramer interface [polypeptide binding]; other site
700508013655	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
700508013656	5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620
700508013657	catalytic residue [active]
700508013658	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
700508013659	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
700508013660	dimer interface [polypeptide binding]; other site
700508013661	NADP binding site [chemical binding]; other site
700508013662	catalytic residues [active]
700508013663	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
700508013664	Zn binding site [ion binding]; other site
700508013665	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
700508013666	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508013667	NAD(P) binding site [chemical binding]; other site
700508013668	active site
700508013669	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508013670	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508013671	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
700508013672	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
700508013673	putative acyl-acceptor binding pocket; other site
700508013674	DNA polymerase III subunit delta'; Validated; Region: PRK07940
700508013675	DNA polymerase III subunit delta'; Validated; Region: PRK08485
700508013676	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
700508013677	dimerization interface [polypeptide binding]; other site
700508013678	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
700508013679	cyclase homology domain; Region: CHD; cd07302
700508013680	nucleotidyl binding site; other site
700508013681	metal binding site [ion binding]; metal-binding site
700508013682	dimer interface [polypeptide binding]; other site
700508013683	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
700508013684	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
700508013685	active site
700508013686	interdomain interaction site; other site
700508013687	putative metal-binding site [ion binding]; other site
700508013688	nucleotide binding site [chemical binding]; other site
700508013689	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
700508013690	domain I; other site
700508013691	phosphate binding site [ion binding]; other site
700508013692	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
700508013693	domain II; other site
700508013694	domain III; other site
700508013695	nucleotide binding site [chemical binding]; other site
700508013696	DNA binding groove [nucleotide binding]
700508013697	catalytic site [active]
700508013698	domain IV; other site
700508013699	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
700508013700	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
700508013701	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
700508013702	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
700508013703	DNA-binding site [nucleotide binding]; DNA binding site
700508013704	RNA-binding motif; other site
700508013705	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
700508013706	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
700508013707	ATP binding site [chemical binding]; other site
700508013708	putative Mg++ binding site [ion binding]; other site
700508013709	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
700508013710	nucleotide binding region [chemical binding]; other site
700508013711	ATP-binding site [chemical binding]; other site
700508013712	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
700508013713	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
700508013714	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
700508013715	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
700508013716	Type II/IV secretion system protein; Region: T2SE; pfam00437
700508013717	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
700508013718	Walker A motif; other site
700508013719	hexamer interface [polypeptide binding]; other site
700508013720	ATP binding site [chemical binding]; other site
700508013721	Walker B motif; other site
700508013722	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
700508013723	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
700508013724	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
700508013725	acetyl-CoA synthetase; Provisional; Region: PRK00174
700508013726	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
700508013727	active site
700508013728	CoA binding site [chemical binding]; other site
700508013729	acyl-activating enzyme (AAE) consensus motif; other site
700508013730	AMP binding site [chemical binding]; other site
700508013731	acetate binding site [chemical binding]; other site
700508013732	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
700508013733	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
700508013734	Colicin V production protein; Region: Colicin_V; pfam02674
700508013735	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
700508013736	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700508013737	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
700508013738	putative active site [active]
700508013739	putative CoA binding site [chemical binding]; other site
700508013740	nudix motif; other site
700508013741	metal binding site [ion binding]; metal-binding site
700508013742	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
700508013743	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
700508013744	catalytic residues [active]
700508013745	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
700508013746	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
700508013747	minor groove reading motif; other site
700508013748	helix-hairpin-helix signature motif; other site
700508013749	substrate binding pocket [chemical binding]; other site
700508013750	active site
700508013751	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
700508013752	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
700508013753	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
700508013754	ligand binding site [chemical binding]; other site
700508013755	flexible hinge region; other site
700508013756	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
700508013757	putative switch regulator; other site
700508013758	non-specific DNA interactions [nucleotide binding]; other site
700508013759	DNA binding site [nucleotide binding]
700508013760	sequence specific DNA binding site [nucleotide binding]; other site
700508013761	putative cAMP binding site [chemical binding]; other site
700508013762	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
700508013763	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
700508013764	homotrimer interaction site [polypeptide binding]; other site
700508013765	putative active site [active]
700508013766	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
700508013767	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
700508013768	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
700508013769	P loop; other site
700508013770	Nucleotide binding site [chemical binding]; other site
700508013771	DTAP/Switch II; other site
700508013772	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
700508013773	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
700508013774	DTAP/Switch II; other site
700508013775	Switch I; other site
700508013776	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
700508013777	Transcription factor WhiB; Region: Whib; pfam02467
700508013778	Transglycosylase; Region: Transgly; pfam00912
700508013779	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
700508013780	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
700508013781	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
700508013782	phosphodiesterase YaeI; Provisional; Region: PRK11340
700508013783	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
700508013784	putative active site [active]
700508013785	putative metal binding site [ion binding]; other site
700508013786	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
700508013787	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
700508013788	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508013789	catalytic residue [active]
700508013790	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
700508013791	Catalytic domain of Protein Kinases; Region: PKc; cd00180
700508013792	active site
700508013793	ATP binding site [chemical binding]; other site
700508013794	substrate binding site [chemical binding]; other site
700508013795	activation loop (A-loop); other site
700508013796	L-asparagine permease; Provisional; Region: PRK15049
700508013797	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
700508013798	active site
700508013799	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
700508013800	catalytic triad [active]
700508013801	dimer interface [polypeptide binding]; other site
700508013802	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
700508013803	MoxR-like ATPases [General function prediction only]; Region: COG0714
700508013804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508013805	Walker A motif; other site
700508013806	ATP binding site [chemical binding]; other site
700508013807	Walker B motif; other site
700508013808	arginine finger; other site
700508013809	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
700508013810	Protein of unknown function DUF58; Region: DUF58; pfam01882
700508013811	Integral membrane protein DUF95; Region: DUF95; pfam01944
700508013812	Predicted membrane protein/domain [Function unknown]; Region: COG1714
700508013813	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
700508013814	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
700508013815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
700508013816	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
700508013817	putative substrate translocation pore; other site
700508013818	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
700508013819	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
700508013820	Predicted transcriptional regulators [Transcription]; Region: COG1695
700508013821	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
700508013822	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
700508013823	Predicted transcriptional regulators [Transcription]; Region: COG1695
700508013824	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
700508013825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
700508013826	Methyltransferase domain; Region: Methyltransf_11; pfam08241
700508013827	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
700508013828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
700508013829	active site
700508013830	phosphorylation site [posttranslational modification]
700508013831	intermolecular recognition site; other site
700508013832	dimerization interface [polypeptide binding]; other site
700508013833	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
700508013834	DNA binding residues [nucleotide binding]
700508013835	dimerization interface [polypeptide binding]; other site
700508013836	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
700508013837	GAF domain; Region: GAF_3; pfam13492
700508013838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
700508013839	Histidine kinase; Region: HisKA_3; pfam07730
700508013840	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
700508013841	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
700508013842	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
700508013843	putative active site [active]
700508013844	metal binding site [ion binding]; metal-binding site
700508013845	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
700508013846	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508013847	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
700508013848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508013849	Walker A motif; other site
700508013850	ATP binding site [chemical binding]; other site
700508013851	Walker B motif; other site
700508013852	NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266
700508013853	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
700508013854	dimer interface [polypeptide binding]; other site
700508013855	active site
700508013856	metal binding site [ion binding]; metal-binding site
700508013857	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508013858	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508013859	active site
700508013860	haloalkane dehalogenase; Provisional; Region: PRK03204
700508013861	Predicted transcriptional regulators [Transcription]; Region: COG1733
700508013862	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
700508013863	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508013864	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508013865	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508013866	catalytic residue [active]
700508013867	catalytic residue [active]
700508013868	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
700508013869	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
700508013870	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
700508013871	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
700508013872	putative active site [active]
700508013873	putative dimer interface [polypeptide binding]; other site
700508013874	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
700508013875	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
700508013876	ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444
700508013877	PknH-like extracellular domain; Region: PknH_C; pfam14032
700508013878	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
700508013879	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
700508013880	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
700508013881	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
700508013882	aspartate kinase; Reviewed; Region: PRK06635
700508013883	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
700508013884	putative nucleotide binding site [chemical binding]; other site
700508013885	putative catalytic residues [active]
700508013886	putative Mg ion binding site [ion binding]; other site
700508013887	putative aspartate binding site [chemical binding]; other site
700508013888	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
700508013889	putative allosteric regulatory site; other site
700508013890	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
700508013891	putative allosteric regulatory residue; other site
700508013892	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
700508013893	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
700508013894	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
700508013895	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
700508013896	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
700508013897	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
700508013898	active site
700508013899	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
700508013900	domain_subunit interface; other site
700508013901	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
700508013902	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
700508013903	active site
700508013904	FMN binding site [chemical binding]; other site
700508013905	substrate binding site [chemical binding]; other site
700508013906	3Fe-4S cluster binding site [ion binding]; other site
700508013907	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
700508013908	hydroxyglutarate oxidase; Provisional; Region: PRK11728
700508013909	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
700508013910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
700508013911	non-specific DNA binding site [nucleotide binding]; other site
700508013912	salt bridge; other site
700508013913	sequence-specific DNA binding site [nucleotide binding]; other site
700508013914	Cupin domain; Region: Cupin_2; pfam07883
700508013915	D-aminopeptidase; Reviewed; Region: PRK13128
700508013916	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
700508013917	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
700508013918	2-isopropylmalate synthase; Validated; Region: PRK03739
700508013919	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
700508013920	active site
700508013921	catalytic residues [active]
700508013922	metal binding site [ion binding]; metal-binding site
700508013923	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
700508013924	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
700508013925	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
700508013926	active site
700508013927	catalytic site [active]
700508013928	substrate binding site [chemical binding]; other site
700508013929	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
700508013930	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
700508013931	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
700508013932	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
700508013933	catalytic triad [active]
700508013934	recombination protein RecR; Reviewed; Region: recR; PRK00076
700508013935	RecR protein; Region: RecR; pfam02132
700508013936	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
700508013937	putative active site [active]
700508013938	putative metal-binding site [ion binding]; other site
700508013939	tetramer interface [polypeptide binding]; other site
700508013940	hypothetical protein; Validated; Region: PRK00153
700508013941	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
700508013942	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
700508013943	FAD binding domain; Region: FAD_binding_4; pfam01565
700508013944	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
700508013945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
700508013946	S-adenosylmethionine binding site [chemical binding]; other site
700508013947	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
700508013948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
700508013949	Walker A motif; other site
700508013950	ATP binding site [chemical binding]; other site
700508013951	Walker B motif; other site
700508013952	arginine finger; other site
700508013953	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
700508013954	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
700508013955	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
700508013956	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
700508013957	catalytic residue [active]
700508013958	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
700508013959	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
700508013960	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
700508013961	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
700508013962	nucleotide binding site [chemical binding]; other site
700508013963	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
700508013964	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
700508013965	active site
700508013966	DNA binding site [nucleotide binding]
700508013967	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
700508013968	DNA binding site [nucleotide binding]
700508013969	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
700508013970	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
700508013971	active site
700508013972	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
700508013973	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
700508013974	tetramer interface [polypeptide binding]; other site
700508013975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
700508013976	catalytic residue [active]
700508013977	Domain of unknown function (DUF222); Region: DUF222; pfam02720
700508013978	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
700508013979	active site
700508013980	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
700508013981	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
700508013982	active site
700508013983	DNA binding site [nucleotide binding]
700508013984	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
700508013985	DNA binding site [nucleotide binding]
700508013986	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
700508013987	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
700508013988	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
700508013989	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
700508013990	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
700508013991	active site
700508013992	HIGH motif; other site
700508013993	nucleotide binding site [chemical binding]; other site
700508013994	active site
700508013995	KMSKS motif; other site
700508013996	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
700508013997	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
700508013998	substrate binding pocket [chemical binding]; other site
700508013999	membrane-bound complex binding site; other site
700508014000	hinge residues; other site
700508014001	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
700508014002	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
700508014003	dimer interface [polypeptide binding]; other site
700508014004	conserved gate region; other site
700508014005	putative PBP binding loops; other site
700508014006	ABC-ATPase subunit interface; other site
700508014007	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
700508014008	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
700508014009	Walker A/P-loop; other site
700508014010	ATP binding site [chemical binding]; other site
700508014011	Q-loop/lid; other site
700508014012	ABC transporter signature motif; other site
700508014013	Walker B; other site
700508014014	D-loop; other site
700508014015	H-loop/switch region; other site
700508014016	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
700508014017	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
700508014018	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
700508014019	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
700508014020	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
700508014021	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
700508014022	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
700508014023	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
700508014024	Protein of unknown function (DUF732); Region: DUF732; pfam05305
700508014025	PE-PPE domain; Region: PE-PPE; pfam08237
700508014026	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
700508014027	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
700508014028	putative NAD(P) binding site [chemical binding]; other site
700508014029	catalytic Zn binding site [ion binding]; other site
700508014030	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657