-- dump date 20140619_150838 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1303024000001 Domain of unknown function (DUF955); Region: DUF955; cl01076 1303024000002 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1303024000003 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1303024000004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000005 active site 1303024000006 DNA binding site [nucleotide binding] 1303024000007 Int/Topo IB signature motif; other site 1303024000008 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000009 active site 1303024000010 DNA binding site [nucleotide binding] 1303024000011 Int/Topo IB signature motif; other site 1303024000012 putative transposase OrfB; Reviewed; Region: PHA02517 1303024000013 HTH-like domain; Region: HTH_21; pfam13276 1303024000014 Integrase core domain; Region: rve; pfam00665 1303024000015 Integrase core domain; Region: rve_3; cl15866 1303024000016 Transposase; Region: HTH_Tnp_1; cl17663 1303024000017 MT-A70; Region: MT-A70; cl01947 1303024000018 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1303024000019 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1303024000020 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1303024000021 iron-sulfur cluster [ion binding]; other site 1303024000022 [2Fe-2S] cluster binding site [ion binding]; other site 1303024000023 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1303024000024 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1303024000025 PYR/PP interface [polypeptide binding]; other site 1303024000026 dimer interface [polypeptide binding]; other site 1303024000027 tetramer interface [polypeptide binding]; other site 1303024000028 TPP binding site [chemical binding]; other site 1303024000029 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1303024000030 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1303024000031 TPP-binding site [chemical binding]; other site 1303024000032 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1303024000033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024000034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024000035 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1303024000036 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1303024000037 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1303024000038 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1303024000039 Cupin domain; Region: Cupin_2; pfam07883 1303024000040 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1303024000041 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000042 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1303024000043 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000044 DNA binding site [nucleotide binding] 1303024000045 active site 1303024000046 Int/Topo IB signature motif; other site 1303024000047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024000048 non-specific DNA binding site [nucleotide binding]; other site 1303024000049 salt bridge; other site 1303024000050 sequence-specific DNA binding site [nucleotide binding]; other site 1303024000051 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1303024000052 Integrase core domain; Region: rve; pfam00665 1303024000053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1303024000054 Integrase core domain; Region: rve_3; pfam13683 1303024000055 Integrase core domain; Region: rve; pfam00665 1303024000056 AAA domain; Region: AAA_22; pfam13401 1303024000057 Bacterial TniB protein; Region: TniB; pfam05621 1303024000058 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024000059 MULE transposase domain; Region: MULE; pfam10551 1303024000060 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1303024000061 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1303024000062 catalytic residues [active] 1303024000063 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1303024000064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1303024000065 Probable transposase; Region: OrfB_IS605; pfam01385 1303024000066 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1303024000067 transposase; Provisional; Region: PRK06526 1303024000068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024000069 Walker A motif; other site 1303024000070 ATP binding site [chemical binding]; other site 1303024000071 Walker B motif; other site 1303024000072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1303024000073 Integrase core domain; Region: rve; pfam00665 1303024000074 Integrase core domain; Region: rve_3; cl15866 1303024000075 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024000076 MULE transposase domain; Region: MULE; pfam10551 1303024000077 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1303024000078 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 1303024000079 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1303024000080 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024000081 P-loop; other site 1303024000082 Magnesium ion binding site [ion binding]; other site 1303024000083 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024000084 Magnesium ion binding site [ion binding]; other site 1303024000085 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1303024000086 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1303024000087 catalytic residue [active] 1303024000088 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1303024000089 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1303024000090 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1303024000091 DDE superfamily endonuclease; Region: DDE_4; cl17710 1303024000092 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1303024000093 NlpC/P60 family; Region: NLPC_P60; pfam00877 1303024000094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024000095 non-specific DNA binding site [nucleotide binding]; other site 1303024000096 salt bridge; other site 1303024000097 sequence-specific DNA binding site [nucleotide binding]; other site 1303024000098 Transcription factor WhiB; Region: Whib; pfam02467 1303024000099 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1303024000100 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024000101 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1303024000102 DNA methylase; Region: N6_N4_Mtase; pfam01555 1303024000103 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1303024000104 DNA methylase; Region: N6_N4_Mtase; pfam01555 1303024000105 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 1303024000106 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1303024000107 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1303024000108 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1303024000109 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000110 active site 1303024000111 DNA binding site [nucleotide binding] 1303024000112 Int/Topo IB signature motif; other site 1303024000113 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1303024000114 active site 1303024000115 catalytic residues [active] 1303024000116 DNA binding site [nucleotide binding] 1303024000117 Int/Topo IB signature motif; other site 1303024000118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024000119 Transposase; Region: HTH_Tnp_1; cl17663 1303024000120 putative transposase OrfB; Reviewed; Region: PHA02517 1303024000121 HTH-like domain; Region: HTH_21; pfam13276 1303024000122 Integrase core domain; Region: rve; pfam00665 1303024000123 Integrase core domain; Region: rve_3; pfam13683 1303024000124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024000125 NAD(P) binding site [chemical binding]; other site 1303024000126 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1303024000127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024000128 motif II; other site 1303024000129 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1303024000130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024000131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024000132 dimer interface [polypeptide binding]; other site 1303024000133 phosphorylation site [posttranslational modification] 1303024000134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024000135 ATP binding site [chemical binding]; other site 1303024000136 Mg2+ binding site [ion binding]; other site 1303024000137 G-X-G motif; other site 1303024000138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024000139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024000140 active site 1303024000141 phosphorylation site [posttranslational modification] 1303024000142 intermolecular recognition site; other site 1303024000143 dimerization interface [polypeptide binding]; other site 1303024000144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024000145 DNA binding site [nucleotide binding] 1303024000146 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1303024000147 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1303024000148 Ligand binding site; other site 1303024000149 Putative Catalytic site; other site 1303024000150 DXD motif; other site 1303024000151 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1303024000152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1303024000153 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1303024000154 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1303024000155 Moco binding site; other site 1303024000156 metal coordination site [ion binding]; other site 1303024000157 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1303024000158 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1303024000159 DNA binding residues [nucleotide binding] 1303024000160 dimer interface [polypeptide binding]; other site 1303024000161 metal binding site [ion binding]; metal-binding site 1303024000162 AhpC/TSA family; Region: AhpC-TSA; pfam00578 1303024000163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024000164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024000165 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1303024000166 putative catalytic residues [active] 1303024000167 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1303024000168 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1303024000169 NAD(P) binding site [chemical binding]; other site 1303024000170 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1303024000171 CGNR zinc finger; Region: zf-CGNR; pfam11706 1303024000172 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024000173 TIGR03086 family protein; Region: TIGR03086 1303024000174 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1303024000175 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1303024000176 Moco binding site; other site 1303024000177 metal coordination site [ion binding]; other site 1303024000178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1303024000179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024000180 NAD(P) binding site [chemical binding]; other site 1303024000181 active site 1303024000182 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1303024000183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024000184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024000185 DNA binding residues [nucleotide binding] 1303024000186 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1303024000187 iron-sulfur cluster [ion binding]; other site 1303024000188 [2Fe-2S] cluster binding site [ion binding]; other site 1303024000189 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1303024000190 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1303024000191 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1303024000192 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1303024000193 active site 1303024000194 metal binding site [ion binding]; metal-binding site 1303024000195 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1303024000196 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1303024000197 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1303024000198 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024000199 MULE transposase domain; Region: MULE; pfam10551 1303024000200 Domain of unknown function (DUF955); Region: DUF955; cl01076 1303024000201 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1303024000202 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1303024000203 Na binding site [ion binding]; other site 1303024000204 RNA polymerase sigma factor; Provisional; Region: PRK11924 1303024000205 Helix-turn-helix domain; Region: HTH_28; pfam13518 1303024000206 Winged helix-turn helix; Region: HTH_29; pfam13551 1303024000207 Homeodomain-like domain; Region: HTH_32; pfam13565 1303024000208 Integrase core domain; Region: rve; pfam00665 1303024000209 Integrase core domain; Region: rve_3; pfam13683 1303024000210 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1303024000211 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1303024000212 AAA domain; Region: AAA_22; pfam13401 1303024000213 ATP-binding site [chemical binding]; other site 1303024000214 Domain of unknown function (DUF955); Region: DUF955; cl01076 1303024000215 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1303024000216 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1303024000217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000218 active site 1303024000219 DNA binding site [nucleotide binding] 1303024000220 Int/Topo IB signature motif; other site 1303024000221 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000222 active site 1303024000223 Int/Topo IB signature motif; other site 1303024000224 DNA binding site [nucleotide binding] 1303024000225 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1303024000226 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1303024000227 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000228 active site 1303024000229 DNA binding site [nucleotide binding] 1303024000230 Int/Topo IB signature motif; other site 1303024000231 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1303024000232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000233 active site 1303024000234 DNA binding site [nucleotide binding] 1303024000235 Int/Topo IB signature motif; other site 1303024000236 HTH-like domain; Region: HTH_21; pfam13276 1303024000237 Integrase core domain; Region: rve; pfam00665 1303024000238 Transposase; Region: HTH_Tnp_1; cl17663 1303024000239 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 1303024000240 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1303024000241 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 1303024000242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1303024000243 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1303024000244 DNA methylase; Region: N6_N4_Mtase; pfam01555 1303024000245 TrwC relaxase; Region: TrwC; pfam08751 1303024000246 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1303024000247 AAA domain; Region: AAA_30; pfam13604 1303024000248 Family description; Region: UvrD_C_2; pfam13538 1303024000249 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1303024000250 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1303024000251 ATP binding site [chemical binding]; other site 1303024000252 substrate interface [chemical binding]; other site 1303024000253 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1303024000254 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1303024000255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024000256 non-specific DNA binding site [nucleotide binding]; other site 1303024000257 salt bridge; other site 1303024000258 sequence-specific DNA binding site [nucleotide binding]; other site 1303024000259 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1303024000260 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 1303024000261 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1303024000262 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1303024000263 catalytic residues [active] 1303024000264 catalytic nucleophile [active] 1303024000265 Presynaptic Site I dimer interface [polypeptide binding]; other site 1303024000266 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1303024000267 Synaptic Flat tetramer interface [polypeptide binding]; other site 1303024000268 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1303024000269 DNA-binding interface [nucleotide binding]; DNA binding site 1303024000270 cyclase homology domain; Region: CHD; cd07302 1303024000271 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1303024000272 nucleotidyl binding site; other site 1303024000273 metal binding site [ion binding]; metal-binding site 1303024000274 dimer interface [polypeptide binding]; other site 1303024000275 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1303024000276 RNA binding site [nucleotide binding]; other site 1303024000277 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1303024000278 DNA-binding site [nucleotide binding]; DNA binding site 1303024000279 RNA-binding motif; other site 1303024000280 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1303024000281 Abi-like protein; Region: Abi_2; pfam07751 1303024000282 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1303024000283 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024000284 P-loop; other site 1303024000285 Magnesium ion binding site [ion binding]; other site 1303024000286 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1303024000287 NlpC/P60 family; Region: NLPC_P60; pfam00877 1303024000288 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1303024000289 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1303024000290 putative active site [active] 1303024000291 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 1303024000292 V-type ATP synthase subunit I; Validated; Region: PRK05771 1303024000293 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1303024000294 Staphylococcal nuclease homologues; Region: SNc; smart00318 1303024000295 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1303024000296 Catalytic site; other site 1303024000297 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024000298 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1303024000299 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1303024000300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024000301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024000302 non-specific DNA binding site [nucleotide binding]; other site 1303024000303 salt bridge; other site 1303024000304 sequence-specific DNA binding site [nucleotide binding]; other site 1303024000305 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1303024000306 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1303024000307 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1303024000308 dimer interface [polypeptide binding]; other site 1303024000309 ssDNA binding site [nucleotide binding]; other site 1303024000310 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1303024000311 ParB-like nuclease domain; Region: ParBc; pfam02195 1303024000312 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1303024000313 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1303024000314 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1303024000315 catalytic residues [active] 1303024000316 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1303024000317 TrwC relaxase; Region: TrwC; pfam08751 1303024000318 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1303024000319 AAA domain; Region: AAA_30; pfam13604 1303024000320 AAA domain; Region: AAA_22; pfam13401 1303024000321 Family description; Region: UvrD_C_2; pfam13538 1303024000322 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1303024000323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1303024000324 Probable transposase; Region: OrfB_IS605; pfam01385 1303024000325 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1303024000326 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1303024000327 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1303024000328 catalytic residues [active] 1303024000329 catalytic nucleophile [active] 1303024000330 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1303024000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024000332 Walker A motif; other site 1303024000333 ATP binding site [chemical binding]; other site 1303024000334 Walker B motif; other site 1303024000335 arginine finger; other site 1303024000336 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 1303024000337 AAA-like domain; Region: AAA_10; pfam12846 1303024000338 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1303024000339 Winged helix-turn helix; Region: HTH_29; pfam13551 1303024000340 Integrase core domain; Region: rve; pfam00665 1303024000341 Integrase core domain; Region: rve_3; pfam13683 1303024000342 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1303024000343 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1303024000344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1303024000345 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1303024000346 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1303024000347 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1303024000348 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1303024000349 catalytic residues [active] 1303024000350 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1303024000351 active site 1303024000352 catalytic residues [active] 1303024000353 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1303024000354 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1303024000355 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1303024000356 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1303024000357 EspG family; Region: ESX-1_EspG; pfam14011 1303024000358 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1303024000359 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024000360 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1303024000361 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024000362 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024000363 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1303024000364 putative active site [active] 1303024000365 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1303024000366 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1303024000367 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1303024000368 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1303024000369 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1303024000370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024000371 Walker A motif; other site 1303024000372 ATP binding site [chemical binding]; other site 1303024000373 Walker B motif; other site 1303024000374 arginine finger; other site 1303024000375 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1303024000376 DnaA box-binding interface [nucleotide binding]; other site 1303024000377 DNA polymerase III subunit beta; Validated; Region: PRK07761 1303024000378 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1303024000379 putative DNA binding surface [nucleotide binding]; other site 1303024000380 dimer interface [polypeptide binding]; other site 1303024000381 beta-clamp/clamp loader binding surface; other site 1303024000382 beta-clamp/translesion DNA polymerase binding surface; other site 1303024000383 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1303024000384 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1303024000385 recombination protein F; Reviewed; Region: recF; PRK00064 1303024000386 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1303024000387 Walker A/P-loop; other site 1303024000388 ATP binding site [chemical binding]; other site 1303024000389 Q-loop/lid; other site 1303024000390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024000391 ABC transporter signature motif; other site 1303024000392 Walker B; other site 1303024000393 D-loop; other site 1303024000394 H-loop/switch region; other site 1303024000395 hypothetical protein; Provisional; Region: PRK03195 1303024000396 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1303024000397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024000398 ATP binding site [chemical binding]; other site 1303024000399 Mg2+ binding site [ion binding]; other site 1303024000400 G-X-G motif; other site 1303024000401 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1303024000402 anchoring element; other site 1303024000403 dimer interface [polypeptide binding]; other site 1303024000404 ATP binding site [chemical binding]; other site 1303024000405 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1303024000406 active site 1303024000407 putative metal-binding site [ion binding]; other site 1303024000408 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1303024000409 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1303024000410 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1303024000411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1303024000412 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1303024000413 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024000414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024000415 S-adenosylmethionine binding site [chemical binding]; other site 1303024000416 DNA gyrase subunit A; Validated; Region: PRK05560 1303024000417 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1303024000418 CAP-like domain; other site 1303024000419 active site 1303024000420 primary dimer interface [polypeptide binding]; other site 1303024000421 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1303024000422 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1303024000423 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1303024000424 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1303024000425 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1303024000426 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1303024000427 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1303024000428 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1303024000429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024000430 putative substrate translocation pore; other site 1303024000431 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1303024000432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024000433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1303024000434 dimerization interface [polypeptide binding]; other site 1303024000435 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1303024000436 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1303024000437 active site 1303024000438 Rhomboid family; Region: Rhomboid; pfam01694 1303024000439 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024000440 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024000441 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1303024000442 putative septation inhibitor protein; Reviewed; Region: PRK00159 1303024000443 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1303024000444 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1303024000445 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1303024000446 glutamine binding [chemical binding]; other site 1303024000447 catalytic triad [active] 1303024000448 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1303024000449 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1303024000450 active site 1303024000451 ATP binding site [chemical binding]; other site 1303024000452 substrate binding site [chemical binding]; other site 1303024000453 activation loop (A-loop); other site 1303024000454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1303024000455 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1303024000456 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1303024000457 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1303024000458 PASTA domain; Region: PASTA; pfam03793 1303024000459 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1303024000460 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1303024000461 active site 1303024000462 ATP binding site [chemical binding]; other site 1303024000463 substrate binding site [chemical binding]; other site 1303024000464 activation loop (A-loop); other site 1303024000465 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1303024000466 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1303024000467 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1303024000468 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1303024000469 active site 1303024000470 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1303024000471 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1303024000472 phosphopeptide binding site; other site 1303024000473 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1303024000474 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1303024000475 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1303024000476 phosphopeptide binding site; other site 1303024000477 SdpI/YhfL protein family; Region: SdpI; pfam13630 1303024000478 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1303024000479 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1303024000480 SdpI/YhfL protein family; Region: SdpI; pfam13630 1303024000481 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1303024000482 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1303024000483 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024000484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024000485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024000486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024000487 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1303024000488 PPE family; Region: PPE; pfam00823 1303024000489 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1303024000490 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1303024000491 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1303024000492 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024000493 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1303024000494 nucleoside/Zn binding site; other site 1303024000495 dimer interface [polypeptide binding]; other site 1303024000496 catalytic motif [active] 1303024000497 cyanate hydratase; Validated; Region: PRK02866 1303024000498 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1303024000499 oligomer interface [polypeptide binding]; other site 1303024000500 active site 1303024000501 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1303024000502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024000503 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1303024000504 dimerization interface [polypeptide binding]; other site 1303024000505 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1303024000506 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024000507 ATP binding site [chemical binding]; other site 1303024000508 putative Mg++ binding site [ion binding]; other site 1303024000509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024000510 nucleotide binding region [chemical binding]; other site 1303024000511 Helicase associated domain (HA2); Region: HA2; pfam04408 1303024000512 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1303024000513 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1303024000514 short chain dehydrogenase; Provisional; Region: PRK07041 1303024000515 classical (c) SDRs; Region: SDR_c; cd05233 1303024000516 NAD(P) binding site [chemical binding]; other site 1303024000517 active site 1303024000518 AAA domain; Region: AAA_31; pfam13614 1303024000519 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1303024000520 mycothione reductase; Reviewed; Region: PRK07846 1303024000521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024000522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024000523 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1303024000524 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024000525 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024000526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024000527 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024000528 active site 1303024000529 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024000530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024000531 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1303024000532 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1303024000533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1303024000534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024000535 DNA-binding site [nucleotide binding]; DNA binding site 1303024000536 FCD domain; Region: FCD; cl11656 1303024000537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024000538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024000539 putative substrate translocation pore; other site 1303024000540 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1303024000541 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1303024000542 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1303024000543 active site residue [active] 1303024000544 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1303024000545 active site residue [active] 1303024000546 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1303024000547 classical (c) SDRs; Region: SDR_c; cd05233 1303024000548 NAD(P) binding site [chemical binding]; other site 1303024000549 active site 1303024000550 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1303024000551 classical (c) SDRs; Region: SDR_c; cd05233 1303024000552 NAD(P) binding site [chemical binding]; other site 1303024000553 active site 1303024000554 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024000555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024000556 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024000557 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024000558 active site 1303024000559 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1303024000560 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1303024000561 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1303024000562 active site 1303024000563 Fe binding site [ion binding]; other site 1303024000564 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1303024000565 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1303024000566 Bacterial transcriptional regulator; Region: IclR; pfam01614 1303024000567 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024000568 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024000569 substrate binding pocket [chemical binding]; other site 1303024000570 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1303024000571 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1303024000572 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1303024000573 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1303024000574 Predicted transcriptional regulators [Transcription]; Region: COG1695 1303024000575 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1303024000576 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024000577 MarR family; Region: MarR; pfam01047 1303024000578 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1303024000579 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1303024000580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024000581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024000582 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1303024000583 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1303024000584 alkaline phosphatase; Provisional; Region: PRK10518 1303024000585 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1303024000586 active site 1303024000587 dimer interface [polypeptide binding]; other site 1303024000588 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1303024000589 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1303024000590 FMN-binding pocket [chemical binding]; other site 1303024000591 flavin binding motif; other site 1303024000592 phosphate binding motif [ion binding]; other site 1303024000593 beta-alpha-beta structure motif; other site 1303024000594 NAD binding pocket [chemical binding]; other site 1303024000595 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024000596 catalytic loop [active] 1303024000597 iron binding site [ion binding]; other site 1303024000598 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024000599 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024000600 short chain dehydrogenase; Provisional; Region: PRK07832 1303024000601 classical (c) SDRs; Region: SDR_c; cd05233 1303024000602 NAD(P) binding site [chemical binding]; other site 1303024000603 active site 1303024000604 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1303024000605 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1303024000606 active site 1303024000607 dimer interface [polypeptide binding]; other site 1303024000608 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1303024000609 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1303024000610 active site 1303024000611 FMN binding site [chemical binding]; other site 1303024000612 substrate binding site [chemical binding]; other site 1303024000613 3Fe-4S cluster binding site [ion binding]; other site 1303024000614 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1303024000615 domain interface; other site 1303024000616 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1303024000617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024000618 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1303024000619 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1303024000620 active site 1303024000621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1303024000622 sequence-specific DNA binding site [nucleotide binding]; other site 1303024000623 salt bridge; other site 1303024000624 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1303024000625 hypothetical protein; Provisional; Region: PRK07945 1303024000626 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1303024000627 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1303024000628 active site 1303024000629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024000630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024000631 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024000632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024000633 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1303024000634 classical (c) SDRs; Region: SDR_c; cd05233 1303024000635 NAD(P) binding site [chemical binding]; other site 1303024000636 active site 1303024000637 Cytochrome P450; Region: p450; cl12078 1303024000638 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024000639 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024000640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024000641 S-adenosylmethionine binding site [chemical binding]; other site 1303024000642 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024000643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024000644 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1303024000645 FAD binding domain; Region: FAD_binding_4; pfam01565 1303024000646 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1303024000647 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1303024000648 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1303024000649 dimer interface [polypeptide binding]; other site 1303024000650 active site 1303024000651 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1303024000652 substrate binding site [chemical binding]; other site 1303024000653 catalytic residue [active] 1303024000654 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1303024000655 CopC domain; Region: CopC; pfam04234 1303024000656 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1303024000657 Domain of unknown function (DUF955); Region: DUF955; cl01076 1303024000658 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1303024000659 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1303024000660 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1303024000661 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1303024000662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1303024000663 active site residue [active] 1303024000664 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1303024000665 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1303024000666 putative active site [active] 1303024000667 catalytic site [active] 1303024000668 putative metal binding site [ion binding]; other site 1303024000669 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1303024000670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1303024000671 metal binding site [ion binding]; metal-binding site 1303024000672 active site 1303024000673 I-site; other site 1303024000674 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024000675 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1303024000676 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1303024000677 Ferritin-like domain; Region: Ferritin; pfam00210 1303024000678 ferroxidase diiron center [ion binding]; other site 1303024000679 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1303024000680 Ferritin-like domain; Region: Ferritin; pfam00210 1303024000681 ferroxidase diiron center [ion binding]; other site 1303024000682 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1303024000683 CAAX protease self-immunity; Region: Abi; pfam02517 1303024000684 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024000685 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1303024000686 prephenate dehydratase; Provisional; Region: PRK11898 1303024000687 Prephenate dehydratase; Region: PDT; pfam00800 1303024000688 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1303024000689 putative L-Phe binding site [chemical binding]; other site 1303024000690 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024000691 catalytic core [active] 1303024000692 pyruvate dehydrogenase; Provisional; Region: PRK09124 1303024000693 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1303024000694 PYR/PP interface [polypeptide binding]; other site 1303024000695 dimer interface [polypeptide binding]; other site 1303024000696 tetramer interface [polypeptide binding]; other site 1303024000697 TPP binding site [chemical binding]; other site 1303024000698 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1303024000699 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1303024000700 TPP-binding site [chemical binding]; other site 1303024000701 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024000702 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024000703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024000704 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024000705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024000706 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024000707 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1303024000708 classical (c) SDRs; Region: SDR_c; cd05233 1303024000709 NAD(P) binding site [chemical binding]; other site 1303024000710 active site 1303024000711 short chain dehydrogenase; Provisional; Region: PRK07832 1303024000712 classical (c) SDRs; Region: SDR_c; cd05233 1303024000713 NAD(P) binding site [chemical binding]; other site 1303024000714 active site 1303024000715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024000716 MgtC family; Region: MgtC; pfam02308 1303024000717 EspG family; Region: ESX-1_EspG; pfam14011 1303024000718 PPE family; Region: PPE; pfam00823 1303024000719 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1303024000720 Septum formation; Region: Septum_form; pfam13845 1303024000721 Septum formation; Region: Septum_form; pfam13845 1303024000722 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1303024000723 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1303024000724 seryl-tRNA synthetase; Provisional; Region: PRK05431 1303024000725 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1303024000726 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1303024000727 dimer interface [polypeptide binding]; other site 1303024000728 active site 1303024000729 motif 1; other site 1303024000730 motif 2; other site 1303024000731 motif 3; other site 1303024000732 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024000733 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1303024000734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1303024000735 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1303024000736 iron-sulfur cluster [ion binding]; other site 1303024000737 [2Fe-2S] cluster binding site [ion binding]; other site 1303024000738 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1303024000739 MarR family; Region: MarR; pfam01047 1303024000740 Predicted ATPase [General function prediction only]; Region: COG3910 1303024000741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1303024000742 Walker A/P-loop; other site 1303024000743 ATP binding site [chemical binding]; other site 1303024000744 Q-loop/lid; other site 1303024000745 ABC transporter signature motif; other site 1303024000746 Walker B; other site 1303024000747 D-loop; other site 1303024000748 H-loop/switch region; other site 1303024000749 Nitronate monooxygenase; Region: NMO; pfam03060 1303024000750 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1303024000751 FMN binding site [chemical binding]; other site 1303024000752 substrate binding site [chemical binding]; other site 1303024000753 putative catalytic residue [active] 1303024000754 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1303024000755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024000756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024000757 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1303024000758 putative dimerization interface [polypeptide binding]; other site 1303024000759 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 1303024000760 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1303024000761 active site 1303024000762 ATP binding site [chemical binding]; other site 1303024000763 Phosphotransferase enzyme family; Region: APH; pfam01636 1303024000764 antibiotic binding site [chemical binding]; other site 1303024000765 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1303024000766 classical (c) SDRs; Region: SDR_c; cd05233 1303024000767 NAD(P) binding site [chemical binding]; other site 1303024000768 active site 1303024000769 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1303024000770 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1303024000771 putative acyl-acceptor binding pocket; other site 1303024000772 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1303024000773 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1303024000774 putative acyl-acceptor binding pocket; other site 1303024000775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024000776 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1303024000777 active site 1303024000778 motif I; other site 1303024000779 motif II; other site 1303024000780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024000781 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1303024000782 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1303024000783 amidase catalytic site [active] 1303024000784 Zn binding residues [ion binding]; other site 1303024000785 substrate binding site [chemical binding]; other site 1303024000786 LGFP repeat; Region: LGFP; pfam08310 1303024000787 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1303024000788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024000789 UDP-galactopyranose mutase; Region: GLF; pfam03275 1303024000790 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1303024000791 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1303024000792 active site 1303024000793 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1303024000794 UbiA prenyltransferase family; Region: UbiA; pfam01040 1303024000795 Predicted esterase [General function prediction only]; Region: COG0627 1303024000796 Putative esterase; Region: Esterase; pfam00756 1303024000797 Predicted esterase [General function prediction only]; Region: COG0627 1303024000798 Cutinase; Region: Cutinase; pfam01083 1303024000799 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1303024000800 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1303024000801 acyl-activating enzyme (AAE) consensus motif; other site 1303024000802 active site 1303024000803 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1303024000804 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1303024000805 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1303024000806 active site 1303024000807 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1303024000808 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1303024000809 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1303024000810 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1303024000811 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1303024000812 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1303024000813 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1303024000814 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1303024000815 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1303024000816 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1303024000817 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1303024000818 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1303024000819 AAA ATPase domain; Region: AAA_16; pfam13191 1303024000820 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1303024000821 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1303024000822 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1303024000823 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1303024000824 classical (c) SDRs; Region: SDR_c; cd05233 1303024000825 NAD(P) binding site [chemical binding]; other site 1303024000826 active site 1303024000827 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1303024000828 FAD binding domain; Region: FAD_binding_4; pfam01565 1303024000829 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1303024000830 Predicted membrane protein [Function unknown]; Region: COG2246 1303024000831 GtrA-like protein; Region: GtrA; pfam04138 1303024000832 dihydroxyacetone kinase; Provisional; Region: PRK14479 1303024000833 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1303024000834 DAK2 domain; Region: Dak2; pfam02734 1303024000835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024000836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024000837 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1303024000838 DNA-binding site [nucleotide binding]; DNA binding site 1303024000839 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024000840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024000841 homodimer interface [polypeptide binding]; other site 1303024000842 catalytic residue [active] 1303024000843 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1303024000844 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1303024000845 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1303024000846 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1303024000847 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1303024000848 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1303024000849 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1303024000850 active site 1303024000851 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1303024000852 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1303024000853 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1303024000854 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1303024000855 active site 1303024000856 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1303024000857 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1303024000858 Walker A/P-loop; other site 1303024000859 ATP binding site [chemical binding]; other site 1303024000860 Q-loop/lid; other site 1303024000861 ABC transporter signature motif; other site 1303024000862 Walker B; other site 1303024000863 D-loop; other site 1303024000864 H-loop/switch region; other site 1303024000865 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1303024000866 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1303024000867 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1303024000868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024000869 catalytic residue [active] 1303024000870 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1303024000871 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1303024000872 NAD(P) binding site [chemical binding]; other site 1303024000873 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024000874 MarR family; Region: MarR; pfam01047 1303024000875 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1303024000876 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1303024000877 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000878 DNA binding site [nucleotide binding] 1303024000879 Int/Topo IB signature motif; other site 1303024000880 active site 1303024000881 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1303024000882 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1303024000883 catalytic residues [active] 1303024000884 catalytic nucleophile [active] 1303024000885 Presynaptic Site I dimer interface [polypeptide binding]; other site 1303024000886 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1303024000887 Synaptic Flat tetramer interface [polypeptide binding]; other site 1303024000888 Synaptic Site I dimer interface [polypeptide binding]; other site 1303024000889 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1303024000890 DNA-binding interface [nucleotide binding]; DNA binding site 1303024000891 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1303024000892 MT-A70; Region: MT-A70; cl01947 1303024000893 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1303024000894 active site 1303024000895 catalytic site [active] 1303024000896 substrate binding site [chemical binding]; other site 1303024000897 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1303024000898 active site 1303024000899 DNA binding site [nucleotide binding] 1303024000900 catalytic site [active] 1303024000901 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1303024000902 DNA-binding residues [nucleotide binding]; DNA binding site 1303024000903 nucleotide binding site [chemical binding]; other site 1303024000904 polymerase nucleotide-binding site; other site 1303024000905 primase nucleotide-binding site [nucleotide binding]; other site 1303024000906 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024000907 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1303024000908 nucleoside/Zn binding site; other site 1303024000909 dimer interface [polypeptide binding]; other site 1303024000910 catalytic motif [active] 1303024000911 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1303024000912 prephenate dehydrogenase; Validated; Region: PRK06545 1303024000913 prephenate dehydrogenase; Validated; Region: PRK08507 1303024000914 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1303024000915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024000916 ABC-ATPase subunit interface; other site 1303024000917 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1303024000918 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1303024000919 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1303024000920 Walker A/P-loop; other site 1303024000921 ATP binding site [chemical binding]; other site 1303024000922 Q-loop/lid; other site 1303024000923 ABC transporter signature motif; other site 1303024000924 Walker B; other site 1303024000925 D-loop; other site 1303024000926 H-loop/switch region; other site 1303024000927 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1303024000928 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1303024000929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024000930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024000931 short chain dehydrogenase; Provisional; Region: PRK07890 1303024000932 classical (c) SDRs; Region: SDR_c; cd05233 1303024000933 NAD(P) binding site [chemical binding]; other site 1303024000934 active site 1303024000935 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1303024000936 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1303024000937 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024000938 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024000939 active site 1303024000940 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024000941 catalytic core [active] 1303024000942 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1303024000943 choline dehydrogenase; Validated; Region: PRK02106 1303024000944 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1303024000945 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1303024000946 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1303024000947 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1303024000948 putative hydrophobic ligand binding site [chemical binding]; other site 1303024000949 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1303024000950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024000951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024000952 homodimer interface [polypeptide binding]; other site 1303024000953 catalytic residue [active] 1303024000954 TQXA domain; Region: TQXA_dom; TIGR03934 1303024000955 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1303024000956 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1303024000957 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024000958 catalytic residue [active] 1303024000959 Predicted transcriptional regulator [Transcription]; Region: COG2345 1303024000960 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024000961 dimerization interface [polypeptide binding]; other site 1303024000962 putative DNA binding site [nucleotide binding]; other site 1303024000963 putative Zn2+ binding site [ion binding]; other site 1303024000964 OsmC-like protein; Region: OsmC; pfam02566 1303024000965 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024000966 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024000967 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 1303024000968 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1303024000969 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024000970 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1303024000971 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1303024000972 D5 N terminal like; Region: D5_N; smart00885 1303024000973 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024000974 MULE transposase domain; Region: MULE; pfam10551 1303024000975 MT-A70; Region: MT-A70; cl01947 1303024000976 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1303024000977 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1303024000978 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1303024000979 catalytic residues [active] 1303024000980 catalytic nucleophile [active] 1303024000981 Presynaptic Site I dimer interface [polypeptide binding]; other site 1303024000982 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1303024000983 Synaptic Flat tetramer interface [polypeptide binding]; other site 1303024000984 Synaptic Site I dimer interface [polypeptide binding]; other site 1303024000985 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1303024000986 DNA-binding interface [nucleotide binding]; DNA binding site 1303024000987 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1303024000988 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024000989 active site 1303024000990 DNA binding site [nucleotide binding] 1303024000991 Int/Topo IB signature motif; other site 1303024000992 GXWXG protein; Region: GXWXG; pfam14231 1303024000993 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1303024000994 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1303024000995 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1303024000996 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024000997 Cytochrome P450; Region: p450; cl12078 1303024000998 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1303024000999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1303024001000 substrate binding pocket [chemical binding]; other site 1303024001001 membrane-bound complex binding site; other site 1303024001002 hinge residues; other site 1303024001003 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1303024001004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024001005 dimer interface [polypeptide binding]; other site 1303024001006 conserved gate region; other site 1303024001007 putative PBP binding loops; other site 1303024001008 ABC-ATPase subunit interface; other site 1303024001009 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1303024001010 active site 1303024001011 HIGH motif; other site 1303024001012 nucleotide binding site [chemical binding]; other site 1303024001013 active site 1303024001014 KMSKS motif; other site 1303024001015 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1303024001016 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1303024001017 active site 1303024001018 DNA binding site [nucleotide binding] 1303024001019 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1303024001020 DNA binding site [nucleotide binding] 1303024001021 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1303024001022 nucleotide binding site [chemical binding]; other site 1303024001023 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1303024001024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024001025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024001026 putative substrate translocation pore; other site 1303024001027 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1303024001028 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1303024001029 NAD(P) binding site [chemical binding]; other site 1303024001030 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1303024001031 hydrophobic ligand binding site; other site 1303024001032 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1303024001033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024001034 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024001035 acyl-activating enzyme (AAE) consensus motif; other site 1303024001036 acyl-activating enzyme (AAE) consensus motif; other site 1303024001037 AMP binding site [chemical binding]; other site 1303024001038 active site 1303024001039 CoA binding site [chemical binding]; other site 1303024001040 salicylate hydroxylase; Provisional; Region: PRK08163 1303024001041 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024001042 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1303024001043 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1303024001044 tetramer interface [polypeptide binding]; other site 1303024001045 active site 1303024001046 GAF domain; Region: GAF; pfam01590 1303024001047 GAF domain; Region: GAF_2; pfam13185 1303024001048 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024001049 DDE superfamily endonuclease; Region: DDE_5; cl17874 1303024001050 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024001051 substrate binding pocket [chemical binding]; other site 1303024001052 catalytic triad [active] 1303024001053 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1303024001054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024001055 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1303024001056 NAD(P) binding site [chemical binding]; other site 1303024001057 active site 1303024001058 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1303024001059 Isochorismatase family; Region: Isochorismatase; pfam00857 1303024001060 catalytic triad [active] 1303024001061 conserved cis-peptide bond; other site 1303024001062 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1303024001063 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1303024001064 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1303024001065 glutamine binding [chemical binding]; other site 1303024001066 catalytic triad [active] 1303024001067 active site 1303024001068 Amidohydrolase; Region: Amidohydro_2; pfam04909 1303024001069 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1303024001070 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1303024001071 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1303024001072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024001073 catalytic residue [active] 1303024001074 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1303024001075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024001076 Walker A motif; other site 1303024001077 ATP binding site [chemical binding]; other site 1303024001078 Walker B motif; other site 1303024001079 arginine finger; other site 1303024001080 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1303024001081 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1303024001082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024001083 S-adenosylmethionine binding site [chemical binding]; other site 1303024001084 FAD binding domain; Region: FAD_binding_4; pfam01565 1303024001085 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1303024001086 enolase; Provisional; Region: eno; PRK00077 1303024001087 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1303024001088 metal binding site [ion binding]; metal-binding site 1303024001089 substrate binding pocket [chemical binding]; other site 1303024001090 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 1303024001091 Phosphotransferase enzyme family; Region: APH; pfam01636 1303024001092 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1303024001093 substrate binding site [chemical binding]; other site 1303024001094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001096 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024001097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001098 active site 1303024001099 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1303024001100 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024001101 substrate binding site [chemical binding]; other site 1303024001102 oxyanion hole (OAH) forming residues; other site 1303024001103 trimer interface [polypeptide binding]; other site 1303024001104 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1303024001105 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1303024001106 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1303024001107 active site 1303024001108 metal binding site [ion binding]; metal-binding site 1303024001109 hypothetical protein; Validated; Region: PRK00153 1303024001110 recombination protein RecR; Reviewed; Region: recR; PRK00076 1303024001111 RecR protein; Region: RecR; pfam02132 1303024001112 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1303024001113 putative active site [active] 1303024001114 putative metal-binding site [ion binding]; other site 1303024001115 tetramer interface [polypeptide binding]; other site 1303024001116 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1303024001117 catalytic triad [active] 1303024001118 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1303024001119 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1303024001120 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1303024001121 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024001122 MarR family; Region: MarR_2; pfam12802 1303024001123 Phosphotransferase enzyme family; Region: APH; pfam01636 1303024001124 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1303024001125 putative active site [active] 1303024001126 putative substrate binding site [chemical binding]; other site 1303024001127 ATP binding site [chemical binding]; other site 1303024001128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001129 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1303024001130 active site 1303024001131 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1303024001132 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1303024001133 active site 1303024001134 catalytic site [active] 1303024001135 substrate binding site [chemical binding]; other site 1303024001136 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1303024001137 Dimer interface [polypeptide binding]; other site 1303024001138 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024001139 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024001140 30S ribosomal protein S18; Provisional; Region: PRK13401 1303024001141 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1303024001142 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1303024001143 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1303024001144 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1303024001145 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1303024001146 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1303024001147 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1303024001148 2-isopropylmalate synthase; Validated; Region: PRK03739 1303024001149 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1303024001150 active site 1303024001151 catalytic residues [active] 1303024001152 metal binding site [ion binding]; metal-binding site 1303024001153 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1303024001154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001156 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1303024001157 FMN binding site [chemical binding]; other site 1303024001158 dimer interface [polypeptide binding]; other site 1303024001159 aspartate kinase; Reviewed; Region: PRK06635 1303024001160 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1303024001161 putative nucleotide binding site [chemical binding]; other site 1303024001162 putative catalytic residues [active] 1303024001163 putative Mg ion binding site [ion binding]; other site 1303024001164 putative aspartate binding site [chemical binding]; other site 1303024001165 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1303024001166 putative allosteric regulatory site; other site 1303024001167 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1303024001168 putative allosteric regulatory residue; other site 1303024001169 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1303024001170 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1303024001171 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1303024001172 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1303024001173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024001174 ATP binding site [chemical binding]; other site 1303024001175 Walker B motif; other site 1303024001176 arginine finger; other site 1303024001177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1303024001178 TPR motif; other site 1303024001179 TPR repeat; Region: TPR_11; pfam13414 1303024001180 binding surface 1303024001181 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1303024001182 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1303024001183 TAP-like protein; Region: Abhydrolase_4; pfam08386 1303024001184 Protein of unknown function, DUF486; Region: DUF486; cl01236 1303024001185 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1303024001186 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1303024001187 tetramer interface [polypeptide binding]; other site 1303024001188 heme binding pocket [chemical binding]; other site 1303024001189 NADPH binding site [chemical binding]; other site 1303024001190 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024001191 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024001192 Nitronate monooxygenase; Region: NMO; pfam03060 1303024001193 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1303024001194 FMN binding site [chemical binding]; other site 1303024001195 substrate binding site [chemical binding]; other site 1303024001196 putative catalytic residue [active] 1303024001197 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1303024001198 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1303024001199 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024001200 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1303024001201 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1303024001202 putative substrate binding site [chemical binding]; other site 1303024001203 putative ATP binding site [chemical binding]; other site 1303024001204 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024001205 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024001206 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024001207 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1303024001208 active site 1303024001209 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1303024001210 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1303024001211 dimer interface [polypeptide binding]; other site 1303024001212 active site 1303024001213 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1303024001214 dimer interface [polypeptide binding]; other site 1303024001215 active site 1303024001216 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1303024001217 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1303024001218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024001219 putative substrate translocation pore; other site 1303024001220 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1303024001221 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024001222 SnoaL-like domain; Region: SnoaL_4; pfam13577 1303024001223 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1303024001224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024001225 NAD(P) binding site [chemical binding]; other site 1303024001226 active site 1303024001227 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1303024001228 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1303024001229 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1303024001230 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1303024001231 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1303024001232 putative active site [active] 1303024001233 putative dimer interface [polypeptide binding]; other site 1303024001234 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1303024001235 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1303024001236 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 1303024001237 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1303024001238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024001239 catalytic residue [active] 1303024001240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001242 lipid-transfer protein; Provisional; Region: PRK08256 1303024001243 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024001244 active site 1303024001245 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1303024001246 active site 1303024001247 catalytic site [active] 1303024001248 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024001249 active site 2 [active] 1303024001250 active site 1 [active] 1303024001251 short chain dehydrogenase; Provisional; Region: PRK07791 1303024001252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024001253 NAD(P) binding site [chemical binding]; other site 1303024001254 active site 1303024001255 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1303024001256 amphipathic channel; other site 1303024001257 Asn-Pro-Ala signature motifs; other site 1303024001258 glycerol kinase; Provisional; Region: glpK; PRK00047 1303024001259 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1303024001260 N- and C-terminal domain interface [polypeptide binding]; other site 1303024001261 active site 1303024001262 MgATP binding site [chemical binding]; other site 1303024001263 catalytic site [active] 1303024001264 metal binding site [ion binding]; metal-binding site 1303024001265 putative homotetramer interface [polypeptide binding]; other site 1303024001266 glycerol binding site [chemical binding]; other site 1303024001267 homodimer interface [polypeptide binding]; other site 1303024001268 Predicted transcriptional regulators [Transcription]; Region: COG1695 1303024001269 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1303024001270 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1303024001271 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1303024001272 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1303024001273 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1303024001274 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1303024001275 Integral membrane protein DUF95; Region: DUF95; pfam01944 1303024001276 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1303024001277 Protein of unknown function DUF58; Region: DUF58; pfam01882 1303024001278 MoxR-like ATPases [General function prediction only]; Region: COG0714 1303024001279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024001280 Walker A motif; other site 1303024001281 ATP binding site [chemical binding]; other site 1303024001282 Walker B motif; other site 1303024001283 arginine finger; other site 1303024001284 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1303024001285 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1303024001286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024001287 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024001288 S-adenosylmethionine binding site [chemical binding]; other site 1303024001289 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1303024001290 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1303024001291 active site 1303024001292 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1303024001293 minor groove reading motif; other site 1303024001294 helix-hairpin-helix signature motif; other site 1303024001295 active site 1303024001296 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1303024001297 AAA domain; Region: AAA_30; pfam13604 1303024001298 Family description; Region: UvrD_C_2; pfam13538 1303024001299 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1303024001300 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1303024001301 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1303024001302 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1303024001303 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1303024001304 active site 1303024001305 catalytic triad [active] 1303024001306 oxyanion hole [active] 1303024001307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1303024001308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024001309 Coenzyme A binding pocket [chemical binding]; other site 1303024001310 integrase; Provisional; Region: int; PHA02601 1303024001311 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024001312 active site 1303024001313 DNA binding site [nucleotide binding] 1303024001314 Int/Topo IB signature motif; other site 1303024001315 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1303024001316 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1303024001317 catalytic residues [active] 1303024001318 catalytic nucleophile [active] 1303024001319 Presynaptic Site I dimer interface [polypeptide binding]; other site 1303024001320 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1303024001321 Synaptic Flat tetramer interface [polypeptide binding]; other site 1303024001322 Synaptic Site I dimer interface [polypeptide binding]; other site 1303024001323 DNA binding site [nucleotide binding] 1303024001324 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1303024001325 DNA-binding interface [nucleotide binding]; DNA binding site 1303024001326 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1303024001327 MT-A70; Region: MT-A70; cl01947 1303024001328 GAD-like domain; Region: GAD-like; pfam08887 1303024001329 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 1303024001330 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024001331 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1303024001332 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1303024001333 D5 N terminal like; Region: D5_N; smart00885 1303024001334 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 1303024001335 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024001336 large tegument protein UL36; Provisional; Region: PHA03247 1303024001337 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1303024001338 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1303024001339 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024001340 catalytic residue [active] 1303024001341 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1303024001342 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1303024001343 putative active site [active] 1303024001344 putative metal binding site [ion binding]; other site 1303024001345 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1303024001346 Transglycosylase; Region: Transgly; pfam00912 1303024001347 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1303024001348 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1303024001349 Transcription factor WhiB; Region: Whib; pfam02467 1303024001350 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1303024001351 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1303024001352 DTAP/Switch II; other site 1303024001353 Switch I; other site 1303024001354 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1303024001355 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1303024001356 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1303024001357 P loop; other site 1303024001358 Nucleotide binding site [chemical binding]; other site 1303024001359 DTAP/Switch II; other site 1303024001360 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1303024001361 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1303024001362 homotrimer interaction site [polypeptide binding]; other site 1303024001363 putative active site [active] 1303024001364 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024001365 EamA-like transporter family; Region: EamA; pfam00892 1303024001366 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1303024001367 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1303024001368 ligand binding site [chemical binding]; other site 1303024001369 flexible hinge region; other site 1303024001370 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1303024001371 putative switch regulator; other site 1303024001372 non-specific DNA interactions [nucleotide binding]; other site 1303024001373 DNA binding site [nucleotide binding] 1303024001374 sequence specific DNA binding site [nucleotide binding]; other site 1303024001375 putative cAMP binding site [chemical binding]; other site 1303024001376 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1303024001377 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1303024001378 minor groove reading motif; other site 1303024001379 helix-hairpin-helix signature motif; other site 1303024001380 substrate binding pocket [chemical binding]; other site 1303024001381 active site 1303024001382 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1303024001383 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1303024001384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1303024001385 catalytic residues [active] 1303024001386 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1303024001387 putative active site [active] 1303024001388 putative CoA binding site [chemical binding]; other site 1303024001389 nudix motif; other site 1303024001390 metal binding site [ion binding]; metal-binding site 1303024001391 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1303024001392 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1303024001393 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024001394 PGAP1-like protein; Region: PGAP1; pfam07819 1303024001395 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1303024001396 acetyl-CoA synthetase; Provisional; Region: PRK00174 1303024001397 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1303024001398 active site 1303024001399 CoA binding site [chemical binding]; other site 1303024001400 acyl-activating enzyme (AAE) consensus motif; other site 1303024001401 AMP binding site [chemical binding]; other site 1303024001402 acetate binding site [chemical binding]; other site 1303024001403 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1303024001404 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1303024001405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1303024001406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024001407 dimer interface [polypeptide binding]; other site 1303024001408 conserved gate region; other site 1303024001409 putative PBP binding loops; other site 1303024001410 ABC-ATPase subunit interface; other site 1303024001411 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1303024001412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024001413 dimer interface [polypeptide binding]; other site 1303024001414 conserved gate region; other site 1303024001415 putative PBP binding loops; other site 1303024001416 ABC-ATPase subunit interface; other site 1303024001417 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1303024001418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1303024001419 Walker A/P-loop; other site 1303024001420 ATP binding site [chemical binding]; other site 1303024001421 Q-loop/lid; other site 1303024001422 ABC transporter signature motif; other site 1303024001423 Walker B; other site 1303024001424 D-loop; other site 1303024001425 H-loop/switch region; other site 1303024001426 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1303024001427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1303024001428 Walker A/P-loop; other site 1303024001429 ATP binding site [chemical binding]; other site 1303024001430 Q-loop/lid; other site 1303024001431 ABC transporter signature motif; other site 1303024001432 Walker B; other site 1303024001433 D-loop; other site 1303024001434 H-loop/switch region; other site 1303024001435 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1303024001436 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1303024001437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024001438 motif II; other site 1303024001439 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1303024001440 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1303024001441 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1303024001442 Walker A motif; other site 1303024001443 ATP binding site [chemical binding]; other site 1303024001444 Walker B motif; other site 1303024001445 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1303024001446 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1303024001447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001449 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024001450 Transport protein; Region: actII; TIGR00833 1303024001451 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024001452 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024001453 2TM domain; Region: 2TM; pfam13239 1303024001454 Predicted transcriptional regulators [Transcription]; Region: COG1695 1303024001455 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1303024001456 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1303024001457 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024001458 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1303024001459 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1303024001460 active site 1303024001461 FMN binding site [chemical binding]; other site 1303024001462 substrate binding site [chemical binding]; other site 1303024001463 homotetramer interface [polypeptide binding]; other site 1303024001464 catalytic residue [active] 1303024001465 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1303024001466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024001467 ATP binding site [chemical binding]; other site 1303024001468 putative Mg++ binding site [ion binding]; other site 1303024001469 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1303024001470 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1303024001471 DNA-binding site [nucleotide binding]; DNA binding site 1303024001472 RNA-binding motif; other site 1303024001473 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1303024001474 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1303024001475 active site 1303024001476 interdomain interaction site; other site 1303024001477 putative metal-binding site [ion binding]; other site 1303024001478 nucleotide binding site [chemical binding]; other site 1303024001479 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1303024001480 domain I; other site 1303024001481 phosphate binding site [ion binding]; other site 1303024001482 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1303024001483 domain II; other site 1303024001484 domain III; other site 1303024001485 nucleotide binding site [chemical binding]; other site 1303024001486 DNA binding groove [nucleotide binding] 1303024001487 catalytic site [active] 1303024001488 domain IV; other site 1303024001489 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1303024001490 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1303024001491 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1303024001492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1303024001493 dimerization interface [polypeptide binding]; other site 1303024001494 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1303024001495 cyclase homology domain; Region: CHD; cd07302 1303024001496 nucleotidyl binding site; other site 1303024001497 metal binding site [ion binding]; metal-binding site 1303024001498 dimer interface [polypeptide binding]; other site 1303024001499 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1303024001500 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1303024001501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1303024001502 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1303024001503 CAAX protease self-immunity; Region: Abi; pfam02517 1303024001504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001506 WHG domain; Region: WHG; pfam13305 1303024001507 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1303024001508 Predicted acyl esterases [General function prediction only]; Region: COG2936 1303024001509 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1303024001510 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1303024001511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024001512 NAD(P) binding site [chemical binding]; other site 1303024001513 active site 1303024001514 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1303024001515 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1303024001516 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1303024001517 Ligand binding site; other site 1303024001518 Putative Catalytic site; other site 1303024001519 DXD motif; other site 1303024001520 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1303024001521 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1303024001522 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1303024001523 Zn binding site [ion binding]; other site 1303024001524 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1303024001525 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024001526 acyl-activating enzyme (AAE) consensus motif; other site 1303024001527 AMP binding site [chemical binding]; other site 1303024001528 active site 1303024001529 CoA binding site [chemical binding]; other site 1303024001530 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024001531 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1303024001532 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1303024001533 putative trimer interface [polypeptide binding]; other site 1303024001534 putative CoA binding site [chemical binding]; other site 1303024001535 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1303024001536 putative trimer interface [polypeptide binding]; other site 1303024001537 putative CoA binding site [chemical binding]; other site 1303024001538 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1303024001539 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1303024001540 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1303024001541 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024001542 catalytic residue [active] 1303024001543 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024001544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024001545 classical (c) SDRs; Region: SDR_c; cd05233 1303024001546 NAD(P) binding site [chemical binding]; other site 1303024001547 active site 1303024001548 putative OHCU decarboxylase; Provisional; Region: PRK13798 1303024001549 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1303024001550 dimer interface [polypeptide binding]; other site 1303024001551 substrate binding site [chemical binding]; other site 1303024001552 metal binding sites [ion binding]; metal-binding site 1303024001553 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1303024001554 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1303024001555 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1303024001556 putative hydrolase; Region: TIGR03624 1303024001557 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1303024001558 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1303024001559 TilS substrate binding domain; Region: TilS; pfam09179 1303024001560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1303024001561 active site 1303024001562 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1303024001563 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1303024001564 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1303024001565 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1303024001566 putative NAD(P) binding site [chemical binding]; other site 1303024001567 catalytic Zn binding site [ion binding]; other site 1303024001568 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024001569 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1303024001570 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024001571 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024001572 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 1303024001573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001575 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1303024001576 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1303024001577 metal ion-dependent adhesion site (MIDAS); other site 1303024001578 FtsH Extracellular; Region: FtsH_ext; pfam06480 1303024001579 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1303024001580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024001581 Walker A motif; other site 1303024001582 ATP binding site [chemical binding]; other site 1303024001583 Walker B motif; other site 1303024001584 arginine finger; other site 1303024001585 Peptidase family M41; Region: Peptidase_M41; pfam01434 1303024001586 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1303024001587 homodecamer interface [polypeptide binding]; other site 1303024001588 GTP cyclohydrolase I; Provisional; Region: PLN03044 1303024001589 active site 1303024001590 putative catalytic site residues [active] 1303024001591 zinc binding site [ion binding]; other site 1303024001592 GTP-CH-I/GFRP interaction surface; other site 1303024001593 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1303024001594 dihydropteroate synthase; Region: DHPS; TIGR01496 1303024001595 substrate binding pocket [chemical binding]; other site 1303024001596 dimer interface [polypeptide binding]; other site 1303024001597 inhibitor binding site; inhibition site 1303024001598 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1303024001599 homooctamer interface [polypeptide binding]; other site 1303024001600 active site 1303024001601 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1303024001602 catalytic center binding site [active] 1303024001603 ATP binding site [chemical binding]; other site 1303024001604 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1303024001605 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1303024001606 Rossmann-like domain; Region: Rossmann-like; pfam10727 1303024001607 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1303024001608 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1303024001609 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1303024001610 active site 1303024001611 ATP-binding site [chemical binding]; other site 1303024001612 pantoate-binding site; other site 1303024001613 HXXH motif; other site 1303024001614 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1303024001615 tetramerization interface [polypeptide binding]; other site 1303024001616 active site 1303024001617 pantothenate kinase; Reviewed; Region: PRK13318 1303024001618 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1303024001619 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1303024001620 dimer interface [polypeptide binding]; other site 1303024001621 putative anticodon binding site; other site 1303024001622 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1303024001623 motif 1; other site 1303024001624 dimer interface [polypeptide binding]; other site 1303024001625 active site 1303024001626 motif 2; other site 1303024001627 motif 3; other site 1303024001628 Lsr2; Region: Lsr2; pfam11774 1303024001629 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1303024001630 Clp amino terminal domain; Region: Clp_N; pfam02861 1303024001631 Clp amino terminal domain; Region: Clp_N; pfam02861 1303024001632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024001633 Walker A motif; other site 1303024001634 ATP binding site [chemical binding]; other site 1303024001635 Walker B motif; other site 1303024001636 arginine finger; other site 1303024001637 UvrB/uvrC motif; Region: UVR; pfam02151 1303024001638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024001639 Walker A motif; other site 1303024001640 ATP binding site [chemical binding]; other site 1303024001641 Walker B motif; other site 1303024001642 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1303024001643 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1303024001644 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1303024001645 putative ligand binding residues [chemical binding]; other site 1303024001646 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1303024001647 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1303024001648 Walker A/P-loop; other site 1303024001649 ATP binding site [chemical binding]; other site 1303024001650 Q-loop/lid; other site 1303024001651 ABC transporter signature motif; other site 1303024001652 Walker B; other site 1303024001653 D-loop; other site 1303024001654 H-loop/switch region; other site 1303024001655 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1303024001656 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1303024001657 dimer interface [polypeptide binding]; other site 1303024001658 putative PBP binding regions; other site 1303024001659 ABC-ATPase subunit interface; other site 1303024001660 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1303024001661 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1303024001662 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1303024001663 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1303024001664 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024001665 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1303024001666 catalytic site [active] 1303024001667 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1303024001668 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1303024001669 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1303024001670 conserved cys residue [active] 1303024001671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024001672 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1303024001673 endonuclease III; Region: ENDO3c; smart00478 1303024001674 minor groove reading motif; other site 1303024001675 helix-hairpin-helix signature motif; other site 1303024001676 substrate binding pocket [chemical binding]; other site 1303024001677 active site 1303024001678 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1303024001679 active site clefts [active] 1303024001680 zinc binding site [ion binding]; other site 1303024001681 dimer interface [polypeptide binding]; other site 1303024001682 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1303024001683 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1303024001684 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1303024001685 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1303024001686 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1303024001687 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024001688 CoenzymeA binding site [chemical binding]; other site 1303024001689 subunit interaction site [polypeptide binding]; other site 1303024001690 PHB binding site; other site 1303024001691 DNA repair protein RadA; Provisional; Region: PRK11823 1303024001692 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1303024001693 Walker A motif; other site 1303024001694 ATP binding site [chemical binding]; other site 1303024001695 Walker B motif; other site 1303024001696 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1303024001697 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024001698 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024001699 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1303024001700 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1303024001701 substrate binding site; other site 1303024001702 dimer interface; other site 1303024001703 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1303024001704 homotrimer interaction site [polypeptide binding]; other site 1303024001705 zinc binding site [ion binding]; other site 1303024001706 CDP-binding sites; other site 1303024001707 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1303024001708 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1303024001709 active site 1303024001710 HIGH motif; other site 1303024001711 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1303024001712 KMSKS motif; other site 1303024001713 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1303024001714 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1303024001715 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1303024001716 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1303024001717 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1303024001718 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1303024001719 active site 1303024001720 catalytic site [active] 1303024001721 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1303024001722 putative active site [active] 1303024001723 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1303024001724 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1303024001725 dimer interface [polypeptide binding]; other site 1303024001726 putative PBP binding regions; other site 1303024001727 ABC-ATPase subunit interface; other site 1303024001728 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1303024001729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024001730 Walker A/P-loop; other site 1303024001731 ATP binding site [chemical binding]; other site 1303024001732 Q-loop/lid; other site 1303024001733 ABC transporter signature motif; other site 1303024001734 Walker B; other site 1303024001735 D-loop; other site 1303024001736 H-loop/switch region; other site 1303024001737 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1303024001738 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1303024001739 intersubunit interface [polypeptide binding]; other site 1303024001740 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1303024001741 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1303024001742 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1303024001743 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1303024001744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001746 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001747 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024001748 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024001749 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024001750 active site 1303024001751 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1303024001752 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1303024001753 FAD binding pocket [chemical binding]; other site 1303024001754 FAD binding motif [chemical binding]; other site 1303024001755 phosphate binding motif [ion binding]; other site 1303024001756 beta-alpha-beta structure motif; other site 1303024001757 NAD(p) ribose binding residues [chemical binding]; other site 1303024001758 NAD binding pocket [chemical binding]; other site 1303024001759 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1303024001760 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024001761 catalytic loop [active] 1303024001762 iron binding site [ion binding]; other site 1303024001763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001764 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1303024001765 Flavin binding site [chemical binding]; other site 1303024001766 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1303024001767 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1303024001768 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1303024001769 active site 1303024001770 Fe binding site [ion binding]; other site 1303024001771 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1303024001772 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1303024001773 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1303024001774 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1303024001775 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1303024001776 amphipathic channel; other site 1303024001777 Asn-Pro-Ala signature motifs; other site 1303024001778 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1303024001779 Predicted membrane protein [Function unknown]; Region: COG4270 1303024001780 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024001781 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024001782 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024001783 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024001784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001785 active site 1303024001786 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001787 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024001788 active site 1303024001789 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1303024001790 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1303024001791 acyl-activating enzyme (AAE) consensus motif; other site 1303024001792 putative AMP binding site [chemical binding]; other site 1303024001793 putative active site [active] 1303024001794 putative CoA binding site [chemical binding]; other site 1303024001795 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001796 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1303024001797 FAD binding site [chemical binding]; other site 1303024001798 substrate binding site [chemical binding]; other site 1303024001799 catalytic base [active] 1303024001800 short chain dehydrogenase; Provisional; Region: PRK07831 1303024001801 classical (c) SDRs; Region: SDR_c; cd05233 1303024001802 NAD(P) binding site [chemical binding]; other site 1303024001803 active site 1303024001804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001806 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1303024001807 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1303024001808 dimer interface [polypeptide binding]; other site 1303024001809 active site 1303024001810 Nitronate monooxygenase; Region: NMO; pfam03060 1303024001811 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1303024001812 FMN binding site [chemical binding]; other site 1303024001813 substrate binding site [chemical binding]; other site 1303024001814 putative catalytic residue [active] 1303024001815 Coenzyme A transferase; Region: CoA_trans; cl17247 1303024001816 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1303024001817 enoyl-CoA hydratase; Provisional; Region: PRK06495 1303024001818 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024001819 substrate binding site [chemical binding]; other site 1303024001820 oxyanion hole (OAH) forming residues; other site 1303024001821 trimer interface [polypeptide binding]; other site 1303024001822 short chain dehydrogenase; Provisional; Region: PRK07856 1303024001823 classical (c) SDRs; Region: SDR_c; cd05233 1303024001824 NAD(P) binding site [chemical binding]; other site 1303024001825 active site 1303024001826 short chain dehydrogenase; Provisional; Region: PRK07791 1303024001827 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1303024001828 homodimer interface [polypeptide binding]; other site 1303024001829 NAD binding site [chemical binding]; other site 1303024001830 active site 1303024001831 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024001832 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024001833 Cytochrome P450; Region: p450; cl12078 1303024001834 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1303024001835 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1303024001836 dimer interface [polypeptide binding]; other site 1303024001837 active site 1303024001838 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024001839 Cytochrome P450; Region: p450; cl12078 1303024001840 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001841 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024001842 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024001843 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024001844 active site 1303024001845 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1303024001846 active site 1303024001847 catalytic site [active] 1303024001848 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1303024001849 DUF35 OB-fold domain; Region: DUF35; pfam01796 1303024001850 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024001851 active site 2 [active] 1303024001852 active site 1 [active] 1303024001853 lipid-transfer protein; Provisional; Region: PRK07855 1303024001854 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024001855 active site 1303024001856 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1303024001857 putative active site [active] 1303024001858 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 1303024001859 enoyl-CoA hydratase; Region: PLN02864 1303024001860 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1303024001861 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1303024001862 dimer interaction site [polypeptide binding]; other site 1303024001863 substrate-binding tunnel; other site 1303024001864 active site 1303024001865 catalytic site [active] 1303024001866 substrate binding site [chemical binding]; other site 1303024001867 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1303024001868 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1303024001869 hypothetical protein; Validated; Region: PRK07121 1303024001870 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1303024001871 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1303024001872 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1303024001873 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1303024001874 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1303024001875 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1303024001876 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1303024001877 active site 1303024001878 catalytic residues [active] 1303024001879 metal binding site [ion binding]; metal-binding site 1303024001880 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1303024001881 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1303024001882 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1303024001883 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024001884 P-loop; other site 1303024001885 Magnesium ion binding site [ion binding]; other site 1303024001886 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1303024001887 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1303024001888 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1303024001889 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1303024001890 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1303024001891 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1303024001892 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1303024001893 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1303024001894 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1303024001895 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1303024001896 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 1303024001897 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1303024001898 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1303024001899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024001900 Walker A motif; other site 1303024001901 ATP binding site [chemical binding]; other site 1303024001902 Walker B motif; other site 1303024001903 arginine finger; other site 1303024001904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024001905 Walker A motif; other site 1303024001906 ATP binding site [chemical binding]; other site 1303024001907 Walker B motif; other site 1303024001908 arginine finger; other site 1303024001909 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1303024001910 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1303024001911 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1303024001912 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1303024001913 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1303024001914 dimer interface [polypeptide binding]; other site 1303024001915 putative functional site; other site 1303024001916 putative MPT binding site; other site 1303024001917 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1303024001918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024001919 active site 1303024001920 motif I; other site 1303024001921 motif II; other site 1303024001922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024001923 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1303024001924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024001925 MspA; Region: MspA; pfam09203 1303024001926 short chain dehydrogenase; Provisional; Region: PRK06197 1303024001927 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1303024001928 putative NAD(P) binding site [chemical binding]; other site 1303024001929 active site 1303024001930 Cupin domain; Region: Cupin_2; pfam07883 1303024001931 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1303024001932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024001933 ATP binding site [chemical binding]; other site 1303024001934 putative Mg++ binding site [ion binding]; other site 1303024001935 short chain dehydrogenase; Provisional; Region: PRK06197 1303024001936 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1303024001937 putative NAD(P) binding site [chemical binding]; other site 1303024001938 active site 1303024001939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024001940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024001941 hypothetical protein; Provisional; Region: PRK07236 1303024001942 hypothetical protein; Validated; Region: PRK05868 1303024001943 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1303024001944 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1303024001945 ring oligomerisation interface [polypeptide binding]; other site 1303024001946 ATP/Mg binding site [chemical binding]; other site 1303024001947 stacking interactions; other site 1303024001948 hinge regions; other site 1303024001949 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1303024001950 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 1303024001951 MoxR-like ATPases [General function prediction only]; Region: COG0714 1303024001952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1303024001953 Protein of unknown function DUF58; Region: DUF58; pfam01882 1303024001954 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1303024001955 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1303024001956 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1303024001957 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1303024001958 acyl-CoA synthetase; Validated; Region: PRK05857 1303024001959 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024001960 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024001961 acyl-activating enzyme (AAE) consensus motif; other site 1303024001962 acyl-activating enzyme (AAE) consensus motif; other site 1303024001963 AMP binding site [chemical binding]; other site 1303024001964 active site 1303024001965 CoA binding site [chemical binding]; other site 1303024001966 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1303024001967 AMP-binding enzyme; Region: AMP-binding; pfam00501 1303024001968 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024001969 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024001970 acyl-activating enzyme (AAE) consensus motif; other site 1303024001971 acyl-activating enzyme (AAE) consensus motif; other site 1303024001972 AMP binding site [chemical binding]; other site 1303024001973 active site 1303024001974 CoA binding site [chemical binding]; other site 1303024001975 thioester reductase domain; Region: Thioester-redct; TIGR01746 1303024001976 NAD(P) binding site [chemical binding]; other site 1303024001977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024001978 active site 1303024001979 active site 1303024001980 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1303024001981 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1303024001982 metal-binding site [ion binding] 1303024001983 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024001984 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1303024001985 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1303024001986 PPE family; Region: PPE; pfam00823 1303024001987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024001988 Domain of unknown function (DUF202); Region: DUF202; cl09954 1303024001989 HNH endonuclease; Region: HNH_3; pfam13392 1303024001990 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024001991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024001992 active site 1303024001993 phosphorylation site [posttranslational modification] 1303024001994 intermolecular recognition site; other site 1303024001995 dimerization interface [polypeptide binding]; other site 1303024001996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024001997 DNA binding site [nucleotide binding] 1303024001998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024001999 HAMP domain; Region: HAMP; pfam00672 1303024002000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024002001 dimer interface [polypeptide binding]; other site 1303024002002 phosphorylation site [posttranslational modification] 1303024002003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024002004 ATP binding site [chemical binding]; other site 1303024002005 Mg2+ binding site [ion binding]; other site 1303024002006 G-X-G motif; other site 1303024002007 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1303024002008 nucleotide binding site/active site [active] 1303024002009 HIT family signature motif; other site 1303024002010 catalytic residue [active] 1303024002011 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1303024002012 EamA-like transporter family; Region: EamA; pfam00892 1303024002013 EamA-like transporter family; Region: EamA; pfam00892 1303024002014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024002015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024002016 putative DNA binding site [nucleotide binding]; other site 1303024002017 dimerization interface [polypeptide binding]; other site 1303024002018 putative Zn2+ binding site [ion binding]; other site 1303024002019 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1303024002020 putative dimerization interface [polypeptide binding]; other site 1303024002021 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024002022 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024002023 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1303024002024 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024002025 active site 1303024002026 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024002027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024002028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002029 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1303024002030 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1303024002031 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1303024002032 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1303024002033 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024002034 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1303024002035 S-formylglutathione hydrolase; Region: PLN02442 1303024002036 aspartate aminotransferase; Provisional; Region: PRK05764 1303024002037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024002038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024002039 homodimer interface [polypeptide binding]; other site 1303024002040 catalytic residue [active] 1303024002041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1303024002042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002043 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1303024002044 adenylosuccinate lyase; Region: purB; TIGR00928 1303024002045 tetramer interface [polypeptide binding]; other site 1303024002046 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1303024002047 ATP binding site [chemical binding]; other site 1303024002048 active site 1303024002049 substrate binding site [chemical binding]; other site 1303024002050 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1303024002051 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024002052 short chain dehydrogenase; Provisional; Region: PRK06940 1303024002053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002055 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1303024002056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024002057 putative substrate translocation pore; other site 1303024002058 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1303024002059 catalytic residues [active] 1303024002060 dimer interface [polypeptide binding]; other site 1303024002061 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1303024002062 Predicted deacetylase [General function prediction only]; Region: COG3233 1303024002063 putative active site [active] 1303024002064 putative Zn binding site [ion binding]; other site 1303024002065 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1303024002066 FAD binding domain; Region: FAD_binding_2; pfam00890 1303024002067 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1303024002068 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1303024002069 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1303024002070 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1303024002071 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1303024002072 putative active site [active] 1303024002073 catalytic triad [active] 1303024002074 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 1303024002075 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1303024002076 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1303024002077 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1303024002078 active site 1303024002079 metal binding site [ion binding]; metal-binding site 1303024002080 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024002081 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1303024002082 DoxX-like family; Region: DoxX_2; pfam13564 1303024002083 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1303024002084 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1303024002085 dimerization interface [polypeptide binding]; other site 1303024002086 ATP binding site [chemical binding]; other site 1303024002087 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1303024002088 dimerization interface [polypeptide binding]; other site 1303024002089 ATP binding site [chemical binding]; other site 1303024002090 Predicted membrane protein [Function unknown]; Region: COG4425 1303024002091 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1303024002092 CAAX protease self-immunity; Region: Abi; pfam02517 1303024002093 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1303024002094 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1303024002095 active site 1303024002096 tetramer interface [polypeptide binding]; other site 1303024002097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1303024002098 active site 1303024002099 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1303024002100 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024002101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024002102 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024002103 MarR family; Region: MarR; pfam01047 1303024002104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002105 NAD(P) binding site [chemical binding]; other site 1303024002106 active site 1303024002107 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1303024002108 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1303024002109 putative NADP binding site [chemical binding]; other site 1303024002110 putative substrate binding site [chemical binding]; other site 1303024002111 active site 1303024002112 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1303024002113 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 1303024002114 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1303024002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024002116 ABC-ATPase subunit interface; other site 1303024002117 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1303024002118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024002119 dimer interface [polypeptide binding]; other site 1303024002120 conserved gate region; other site 1303024002121 ABC-ATPase subunit interface; other site 1303024002122 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1303024002123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1303024002124 Walker A/P-loop; other site 1303024002125 ATP binding site [chemical binding]; other site 1303024002126 Q-loop/lid; other site 1303024002127 ABC transporter signature motif; other site 1303024002128 Walker B; other site 1303024002129 D-loop; other site 1303024002130 H-loop/switch region; other site 1303024002131 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1303024002132 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1303024002133 Walker A/P-loop; other site 1303024002134 ATP binding site [chemical binding]; other site 1303024002135 Q-loop/lid; other site 1303024002136 ABC transporter signature motif; other site 1303024002137 Walker B; other site 1303024002138 D-loop; other site 1303024002139 H-loop/switch region; other site 1303024002140 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1303024002141 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1303024002142 amidase; Provisional; Region: PRK07869 1303024002143 Amidase; Region: Amidase; cl11426 1303024002144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1303024002145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002146 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1303024002147 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1303024002148 iron-sulfur cluster [ion binding]; other site 1303024002149 [2Fe-2S] cluster binding site [ion binding]; other site 1303024002150 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1303024002151 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1303024002152 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1303024002153 dimerization interface [polypeptide binding]; other site 1303024002154 putative ATP binding site [chemical binding]; other site 1303024002155 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1303024002156 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1303024002157 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1303024002158 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1303024002159 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1303024002160 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1303024002161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024002162 catalytic residue [active] 1303024002163 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1303024002164 heme-binding site [chemical binding]; other site 1303024002165 MspA; Region: MspA; pfam09203 1303024002166 Helix-turn-helix domain; Region: HTH_18; pfam12833 1303024002167 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1303024002168 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1303024002169 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1303024002170 active site residue [active] 1303024002171 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1303024002172 active site residue [active] 1303024002173 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1303024002174 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1303024002175 catalytic residues [active] 1303024002176 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1303024002177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024002178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024002179 DNA binding site [nucleotide binding] 1303024002180 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1303024002181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024002182 Coenzyme A binding pocket [chemical binding]; other site 1303024002183 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1303024002184 PBP superfamily domain; Region: PBP_like_2; cl17296 1303024002185 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1303024002186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024002187 dimer interface [polypeptide binding]; other site 1303024002188 conserved gate region; other site 1303024002189 putative PBP binding loops; other site 1303024002190 ABC-ATPase subunit interface; other site 1303024002191 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1303024002192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024002193 dimer interface [polypeptide binding]; other site 1303024002194 conserved gate region; other site 1303024002195 putative PBP binding loops; other site 1303024002196 ABC-ATPase subunit interface; other site 1303024002197 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1303024002198 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1303024002199 Walker A/P-loop; other site 1303024002200 ATP binding site [chemical binding]; other site 1303024002201 Q-loop/lid; other site 1303024002202 ABC transporter signature motif; other site 1303024002203 Walker B; other site 1303024002204 D-loop; other site 1303024002205 H-loop/switch region; other site 1303024002206 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1303024002207 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1303024002208 putative NAD(P) binding site [chemical binding]; other site 1303024002209 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1303024002210 PhoU domain; Region: PhoU; pfam01895 1303024002211 PhoU domain; Region: PhoU; pfam01895 1303024002212 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1303024002213 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1303024002214 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1303024002215 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1303024002216 FMN binding site [chemical binding]; other site 1303024002217 active site 1303024002218 catalytic residues [active] 1303024002219 substrate binding site [chemical binding]; other site 1303024002220 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1303024002221 homodimer interface [polypeptide binding]; other site 1303024002222 putative substrate binding pocket [chemical binding]; other site 1303024002223 diiron center [ion binding]; other site 1303024002224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024002225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1303024002227 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1303024002228 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1303024002229 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1303024002230 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1303024002231 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 1303024002232 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 1303024002233 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1303024002234 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1303024002235 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1303024002236 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024002237 oxidoreductase; Provisional; Region: PRK06196 1303024002238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002239 NAD(P) binding site [chemical binding]; other site 1303024002240 active site 1303024002241 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1303024002242 EamA-like transporter family; Region: EamA; pfam00892 1303024002243 Cupin; Region: Cupin_6; pfam12852 1303024002244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024002245 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024002246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024002247 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1303024002248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024002249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024002250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024002251 non-specific DNA binding site [nucleotide binding]; other site 1303024002252 salt bridge; other site 1303024002253 sequence-specific DNA binding site [nucleotide binding]; other site 1303024002254 Cupin domain; Region: Cupin_2; cl17218 1303024002255 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1303024002256 putative deacylase active site [active] 1303024002257 putative sialic acid transporter; Provisional; Region: PRK12307 1303024002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024002259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024002260 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024002261 active site 1303024002262 DNA binding site [nucleotide binding] 1303024002263 Int/Topo IB signature motif; other site 1303024002264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1303024002265 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1303024002266 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1303024002267 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1303024002268 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1303024002269 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1303024002270 oligomer interface [polypeptide binding]; other site 1303024002271 active site residues [active] 1303024002272 Protein of unknown function (DUF935); Region: DUF935; pfam06074 1303024002273 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1303024002274 AAA domain; Region: AAA_17; pfam13207 1303024002275 AAA domain; Region: AAA_33; pfam13671 1303024002276 Septum formation initiator; Region: DivIC; cl17659 1303024002277 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1303024002278 DNA methylase; Region: N6_N4_Mtase; pfam01555 1303024002279 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1303024002280 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1303024002281 active site 1303024002282 catalytic site [active] 1303024002283 substrate binding site [chemical binding]; other site 1303024002284 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 1303024002285 exonuclease VIII; Reviewed; Region: PRK09709 1303024002286 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1303024002287 Prophage antirepressor [Transcription]; Region: COG3617 1303024002288 BRO family, N-terminal domain; Region: Bro-N; smart01040 1303024002289 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1303024002290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024002291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024002292 non-specific DNA binding site [nucleotide binding]; other site 1303024002293 salt bridge; other site 1303024002294 sequence-specific DNA binding site [nucleotide binding]; other site 1303024002295 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1303024002296 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1303024002297 Int/Topo IB signature motif; other site 1303024002298 Helix-turn-helix domain; Region: HTH_17; cl17695 1303024002299 MspA; Region: MspA; pfam09203 1303024002300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1303024002301 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1303024002302 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1303024002303 Presynaptic Site I dimer interface [polypeptide binding]; other site 1303024002304 catalytic residues [active] 1303024002305 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1303024002306 Synaptic Flat tetramer interface [polypeptide binding]; other site 1303024002307 Synaptic Site I dimer interface [polypeptide binding]; other site 1303024002308 DNA binding site [nucleotide binding] 1303024002309 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1303024002310 DNA-binding interface [nucleotide binding]; DNA binding site 1303024002311 putative transposase OrfB; Reviewed; Region: PHA02517 1303024002312 HTH-like domain; Region: HTH_21; pfam13276 1303024002313 Integrase core domain; Region: rve; pfam00665 1303024002314 Integrase core domain; Region: rve_3; pfam13683 1303024002315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024002316 Transposase; Region: HTH_Tnp_1; cl17663 1303024002317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024002318 Transposase; Region: HTH_Tnp_1; cl17663 1303024002319 putative transposase OrfB; Reviewed; Region: PHA02517 1303024002320 HTH-like domain; Region: HTH_21; pfam13276 1303024002321 Integrase core domain; Region: rve; pfam00665 1303024002322 Integrase core domain; Region: rve_3; pfam13683 1303024002323 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1303024002324 PPE family; Region: PPE; pfam00823 1303024002325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024002326 DNA-binding site [nucleotide binding]; DNA binding site 1303024002327 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1303024002328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024002329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024002330 homodimer interface [polypeptide binding]; other site 1303024002331 catalytic residue [active] 1303024002332 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1303024002333 EamA-like transporter family; Region: EamA; pfam00892 1303024002334 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1303024002335 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024002336 inhibitor-cofactor binding pocket; inhibition site 1303024002337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024002338 catalytic residue [active] 1303024002339 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024002340 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024002341 active site 1303024002342 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1303024002343 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024002344 NAD(P) binding site [chemical binding]; other site 1303024002345 catalytic residues [active] 1303024002346 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1303024002347 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1303024002348 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1303024002349 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024002350 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024002351 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024002352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002353 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1303024002354 NAD(P) binding site [chemical binding]; other site 1303024002355 active site 1303024002356 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1303024002357 putative hydrophobic ligand binding site [chemical binding]; other site 1303024002358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024002359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1303024002361 classical (c) SDRs; Region: SDR_c; cd05233 1303024002362 NAD(P) binding site [chemical binding]; other site 1303024002363 active site 1303024002364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024002365 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1303024002366 substrate binding site [chemical binding]; other site 1303024002367 oxyanion hole (OAH) forming residues; other site 1303024002368 trimer interface [polypeptide binding]; other site 1303024002369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024002370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002371 enoyl-CoA hydratase; Provisional; Region: PRK07799 1303024002372 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024002373 substrate binding site [chemical binding]; other site 1303024002374 oxyanion hole (OAH) forming residues; other site 1303024002375 trimer interface [polypeptide binding]; other site 1303024002376 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1303024002377 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024002378 active site 1303024002379 lipid-transfer protein; Provisional; Region: PRK07937 1303024002380 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1303024002381 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1303024002382 DUF35 OB-fold domain; Region: DUF35; pfam01796 1303024002383 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1303024002384 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1303024002385 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1303024002386 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024002387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024002388 aminotransferase; Validated; Region: PRK07777 1303024002389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024002390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024002391 homodimer interface [polypeptide binding]; other site 1303024002392 catalytic residue [active] 1303024002393 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1303024002394 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1303024002395 dimer interface [polypeptide binding]; other site 1303024002396 active site 1303024002397 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1303024002398 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024002399 substrate binding site [chemical binding]; other site 1303024002400 oxyanion hole (OAH) forming residues; other site 1303024002401 trimer interface [polypeptide binding]; other site 1303024002402 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1303024002403 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1303024002404 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1303024002405 peptide synthase; Provisional; Region: PRK12316 1303024002406 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024002407 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024002408 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1303024002409 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1303024002410 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1303024002411 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1303024002412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002413 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1303024002414 hypothetical protein; Provisional; Region: PRK06834 1303024002415 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024002416 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024002417 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1303024002418 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1303024002419 hydrophobic ligand binding site; other site 1303024002420 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1303024002421 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1303024002422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1303024002423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024002424 ATP binding site [chemical binding]; other site 1303024002425 putative Mg++ binding site [ion binding]; other site 1303024002426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024002427 nucleotide binding region [chemical binding]; other site 1303024002428 ATP-binding site [chemical binding]; other site 1303024002429 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1303024002430 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1303024002431 WYL domain; Region: WYL; pfam13280 1303024002432 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1303024002433 trimer interface [polypeptide binding]; other site 1303024002434 dimer interface [polypeptide binding]; other site 1303024002435 putative active site [active] 1303024002436 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1303024002437 MPT binding site; other site 1303024002438 trimer interface [polypeptide binding]; other site 1303024002439 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1303024002440 MoaE homodimer interface [polypeptide binding]; other site 1303024002441 MoaD interaction [polypeptide binding]; other site 1303024002442 active site residues [active] 1303024002443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024002444 S-adenosylmethionine binding site [chemical binding]; other site 1303024002445 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024002446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024002447 S-adenosylmethionine binding site [chemical binding]; other site 1303024002448 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1303024002449 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1303024002450 MoaE interaction surface [polypeptide binding]; other site 1303024002451 MoeB interaction surface [polypeptide binding]; other site 1303024002452 thiocarboxylated glycine; other site 1303024002453 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1303024002454 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024002455 FeS/SAM binding site; other site 1303024002456 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1303024002457 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1303024002458 DNA-binding site [nucleotide binding]; DNA binding site 1303024002459 RNA-binding motif; other site 1303024002460 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1303024002461 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1303024002462 active site 1303024002463 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1303024002464 H+ Antiporter protein; Region: 2A0121; TIGR00900 1303024002465 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1303024002466 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1303024002467 hydrophobic ligand binding site; other site 1303024002468 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1303024002469 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024002470 MarR family; Region: MarR; pfam01047 1303024002471 H+ Antiporter protein; Region: 2A0121; TIGR00900 1303024002472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024002473 putative substrate translocation pore; other site 1303024002474 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1303024002475 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1303024002476 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1303024002477 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1303024002478 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1303024002479 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1303024002480 Domain of unknown function (DUF202); Region: DUF202; cl09954 1303024002481 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1303024002482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024002483 short chain dehydrogenase; Provisional; Region: PRK08251 1303024002484 classical (c) SDRs; Region: SDR_c; cd05233 1303024002485 NAD(P) binding site [chemical binding]; other site 1303024002486 active site 1303024002487 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024002488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024002489 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1303024002490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002491 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1303024002492 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1303024002493 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024002494 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1303024002495 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1303024002496 MarR family; Region: MarR; pfam01047 1303024002497 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 1303024002498 Ligand binding site; other site 1303024002499 Ligand binding site; other site 1303024002500 Ligand binding site; other site 1303024002501 Putative Catalytic site; other site 1303024002502 DXD motif; other site 1303024002503 Predicted membrane protein [Function unknown]; Region: COG2246 1303024002504 GtrA-like protein; Region: GtrA; pfam04138 1303024002505 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1303024002506 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1303024002507 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024002508 catalytic residue [active] 1303024002509 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1303024002510 Ferredoxin [Energy production and conversion]; Region: COG1146 1303024002511 ferredoxin-NADP+ reductase; Region: PLN02852 1303024002512 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1303024002513 putative dimer interface [polypeptide binding]; other site 1303024002514 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024002515 citrate synthase 2; Provisional; Region: PRK12350 1303024002516 Citrate synthase; Region: Citrate_synt; pfam00285 1303024002517 oxalacetate binding site [chemical binding]; other site 1303024002518 citrylCoA binding site [chemical binding]; other site 1303024002519 coenzyme A binding site [chemical binding]; other site 1303024002520 catalytic triad [active] 1303024002521 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024002522 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1303024002523 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1303024002524 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1303024002525 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1303024002526 acyl-CoA synthetase; Validated; Region: PRK05850 1303024002527 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1303024002528 acyl-activating enzyme (AAE) consensus motif; other site 1303024002529 active site 1303024002530 PE-PPE domain; Region: PE-PPE; pfam08237 1303024002531 Transport protein; Region: actII; TIGR00833 1303024002532 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1303024002533 Condensation domain; Region: Condensation; pfam00668 1303024002534 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1303024002535 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1303024002536 active site 1303024002537 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1303024002538 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1303024002539 KR domain; Region: KR; pfam08659 1303024002540 putative NADP binding site [chemical binding]; other site 1303024002541 active site 1303024002542 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1303024002543 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1303024002544 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1303024002545 active site 1303024002546 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1303024002547 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1303024002548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002549 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1303024002550 Enoylreductase; Region: PKS_ER; smart00829 1303024002551 NAD(P) binding site [chemical binding]; other site 1303024002552 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1303024002553 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1303024002554 putative NADP binding site [chemical binding]; other site 1303024002555 active site 1303024002556 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1303024002557 H+ Antiporter protein; Region: 2A0121; TIGR00900 1303024002558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024002559 putative substrate translocation pore; other site 1303024002560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1303024002561 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1303024002562 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1303024002563 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1303024002564 conserved cys residue [active] 1303024002565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024002566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024002567 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1303024002568 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1303024002569 conserved cys residue [active] 1303024002570 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1303024002571 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1303024002572 dimer interface [polypeptide binding]; other site 1303024002573 active site 1303024002574 citrylCoA binding site [chemical binding]; other site 1303024002575 NADH binding [chemical binding]; other site 1303024002576 cationic pore residues; other site 1303024002577 oxalacetate/citrate binding site [chemical binding]; other site 1303024002578 coenzyme A binding site [chemical binding]; other site 1303024002579 catalytic triad [active] 1303024002580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024002581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024002582 putative substrate translocation pore; other site 1303024002583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024002584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024002585 putative DNA binding site [nucleotide binding]; other site 1303024002586 dimerization interface [polypeptide binding]; other site 1303024002587 putative Zn2+ binding site [ion binding]; other site 1303024002588 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024002589 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1303024002590 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1303024002591 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1303024002592 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024002593 inhibitor-cofactor binding pocket; inhibition site 1303024002594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024002595 catalytic residue [active] 1303024002596 amino acid transporter; Region: 2A0306; TIGR00909 1303024002597 Phosphotransferase enzyme family; Region: APH; pfam01636 1303024002598 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1303024002599 short chain dehydrogenase; Provisional; Region: PRK12829 1303024002600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002601 NAD(P) binding site [chemical binding]; other site 1303024002602 active site 1303024002603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024002604 DNA-binding site [nucleotide binding]; DNA binding site 1303024002605 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1303024002606 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1303024002607 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1303024002608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024002609 HAMP domain; Region: HAMP; pfam00672 1303024002610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024002611 dimer interface [polypeptide binding]; other site 1303024002612 phosphorylation site [posttranslational modification] 1303024002613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024002614 ATP binding site [chemical binding]; other site 1303024002615 Mg2+ binding site [ion binding]; other site 1303024002616 G-X-G motif; other site 1303024002617 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024002618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024002619 active site 1303024002620 phosphorylation site [posttranslational modification] 1303024002621 intermolecular recognition site; other site 1303024002622 dimerization interface [polypeptide binding]; other site 1303024002623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024002624 DNA binding site [nucleotide binding] 1303024002625 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024002626 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024002627 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1303024002628 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024002629 substrate binding site [chemical binding]; other site 1303024002630 oxyanion hole (OAH) forming residues; other site 1303024002631 trimer interface [polypeptide binding]; other site 1303024002632 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1303024002633 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1303024002634 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024002635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024002636 S-adenosylmethionine binding site [chemical binding]; other site 1303024002637 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1303024002638 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1303024002639 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1303024002640 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024002641 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1303024002642 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1303024002643 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1303024002644 Secretory lipase; Region: LIP; pfam03583 1303024002645 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1303024002646 hydrophobic ligand binding site; other site 1303024002647 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1303024002648 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024002649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1303024002650 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1303024002651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024002652 putative substrate translocation pore; other site 1303024002653 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024002654 active site 1 [active] 1303024002655 active site 2 [active] 1303024002656 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1303024002657 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024002658 NAD(P) binding site [chemical binding]; other site 1303024002659 catalytic residues [active] 1303024002660 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1303024002661 MAEBL; Provisional; Region: PTZ00121 1303024002662 hypothetical protein; Validated; Region: PRK02101 1303024002663 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1303024002664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024002665 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1303024002666 DNA polymerase IV; Validated; Region: PRK03858 1303024002667 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1303024002668 active site 1303024002669 DNA binding site [nucleotide binding] 1303024002670 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024002671 MarR family; Region: MarR; pfam01047 1303024002672 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1303024002673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024002674 substrate binding site [chemical binding]; other site 1303024002675 oxyanion hole (OAH) forming residues; other site 1303024002676 trimer interface [polypeptide binding]; other site 1303024002677 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1303024002678 active site 1303024002679 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1303024002680 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1303024002681 NAD(P) binding site [chemical binding]; other site 1303024002682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024002683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002684 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024002685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024002686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024002687 dimerization interface [polypeptide binding]; other site 1303024002688 putative DNA binding site [nucleotide binding]; other site 1303024002689 putative Zn2+ binding site [ion binding]; other site 1303024002690 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1303024002691 putative hydrophobic ligand binding site [chemical binding]; other site 1303024002692 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1303024002693 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024002694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024002695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002696 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1303024002697 ArsC family; Region: ArsC; pfam03960 1303024002698 catalytic residues [active] 1303024002699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024002700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024002701 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1303024002702 dimerization interface [polypeptide binding]; other site 1303024002703 substrate binding pocket [chemical binding]; other site 1303024002704 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1303024002705 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1303024002706 putative NAD(P) binding site [chemical binding]; other site 1303024002707 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1303024002708 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1303024002709 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1303024002710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024002711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024002712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1303024002713 dimerization interface [polypeptide binding]; other site 1303024002714 formate dehydrogenase; Provisional; Region: PRK07574 1303024002715 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1303024002716 dimerization interface [polypeptide binding]; other site 1303024002717 ligand binding site [chemical binding]; other site 1303024002718 NAD binding site [chemical binding]; other site 1303024002719 catalytic site [active] 1303024002720 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1303024002721 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1303024002722 dimer interface [polypeptide binding]; other site 1303024002723 active site 1303024002724 Mannan-binding protein; Region: MVL; pfam12151 1303024002725 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1303024002726 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1303024002727 mce related protein; Region: MCE; pfam02470 1303024002728 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024002729 mce related protein; Region: MCE; pfam02470 1303024002730 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1303024002731 mce related protein; Region: MCE; pfam02470 1303024002732 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1303024002733 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024002734 mce related protein; Region: MCE; pfam02470 1303024002735 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024002736 mce related protein; Region: MCE; pfam02470 1303024002737 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024002738 mce related protein; Region: MCE; pfam02470 1303024002739 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1303024002740 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1303024002741 Permease; Region: Permease; pfam02405 1303024002742 Permease; Region: Permease; pfam02405 1303024002743 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1303024002744 putative ADP-binding pocket [chemical binding]; other site 1303024002745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024002746 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1303024002747 putative active site [active] 1303024002748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1303024002749 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1303024002750 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1303024002751 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1303024002752 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1303024002753 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024002754 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1303024002755 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024002756 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1303024002757 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1303024002758 HD domain; Region: HD_4; pfam13328 1303024002759 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1303024002760 metal binding triad [ion binding]; metal-binding site 1303024002761 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1303024002762 Protein of unknown function DUF262; Region: DUF262; pfam03235 1303024002763 DNA methylase; Region: N6_N4_Mtase; cl17433 1303024002764 Domain of unknown function DUF87; Region: DUF87; pfam01935 1303024002765 AAA-like domain; Region: AAA_10; pfam12846 1303024002766 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024002767 MarR family; Region: MarR; pfam01047 1303024002768 Predicted esterase [General function prediction only]; Region: COG0627 1303024002769 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1303024002770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024002771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002772 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 1303024002773 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1303024002774 cyanate hydratase; Validated; Region: PRK02866 1303024002775 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1303024002776 oligomer interface [polypeptide binding]; other site 1303024002777 active site 1303024002778 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1303024002779 MarR family; Region: MarR; pfam01047 1303024002780 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1303024002781 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1303024002782 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1303024002783 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1303024002784 putative DNA binding site [nucleotide binding]; other site 1303024002785 putative homodimer interface [polypeptide binding]; other site 1303024002786 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1303024002787 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1303024002788 nucleotide binding site [chemical binding]; other site 1303024002789 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1303024002790 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1303024002791 active site 1303024002792 DNA binding site [nucleotide binding] 1303024002793 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1303024002794 DNA binding site [nucleotide binding] 1303024002795 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1303024002796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024002797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024002798 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1303024002799 active site 1303024002800 SAM binding site [chemical binding]; other site 1303024002801 homodimer interface [polypeptide binding]; other site 1303024002802 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1303024002803 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1303024002804 putative DNA binding site [nucleotide binding]; other site 1303024002805 catalytic residue [active] 1303024002806 putative H2TH interface [polypeptide binding]; other site 1303024002807 putative catalytic residues [active] 1303024002808 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1303024002809 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1303024002810 short chain dehydrogenase; Provisional; Region: PRK08251 1303024002811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024002812 NAD(P) binding site [chemical binding]; other site 1303024002813 active site 1303024002814 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1303024002815 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1303024002816 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1303024002817 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1303024002818 D-pathway; other site 1303024002819 Putative ubiquinol binding site [chemical binding]; other site 1303024002820 Low-spin heme (heme b) binding site [chemical binding]; other site 1303024002821 Putative water exit pathway; other site 1303024002822 Binuclear center (heme o3/CuB) [ion binding]; other site 1303024002823 K-pathway; other site 1303024002824 Putative proton exit pathway; other site 1303024002825 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1303024002826 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1303024002827 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1303024002828 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1303024002829 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1303024002830 inhibitor site; inhibition site 1303024002831 active site 1303024002832 dimer interface [polypeptide binding]; other site 1303024002833 catalytic residue [active] 1303024002834 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1303024002835 intersubunit interface [polypeptide binding]; other site 1303024002836 active site 1303024002837 Zn2+ binding site [ion binding]; other site 1303024002838 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024002839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024002840 sequence-specific DNA binding site [nucleotide binding]; other site 1303024002841 salt bridge; other site 1303024002842 Cupin domain; Region: Cupin_2; pfam07883 1303024002843 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1303024002844 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1303024002845 active site 1303024002846 dimer interface [polypeptide binding]; other site 1303024002847 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1303024002848 dimer interface [polypeptide binding]; other site 1303024002849 active site 1303024002850 hypothetical protein; Provisional; Region: PRK07857 1303024002851 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1303024002852 Part of AAA domain; Region: AAA_19; pfam13245 1303024002853 Family description; Region: UvrD_C_2; pfam13538 1303024002854 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1303024002855 Peptidase family M23; Region: Peptidase_M23; pfam01551 1303024002856 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1303024002857 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1303024002858 CoA-ligase; Region: Ligase_CoA; pfam00549 1303024002859 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1303024002860 CoA binding domain; Region: CoA_binding; smart00881 1303024002861 CoA-ligase; Region: Ligase_CoA; pfam00549 1303024002862 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1303024002863 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024002864 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1303024002865 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1303024002866 active site 1303024002867 dimer interface [polypeptide binding]; other site 1303024002868 non-prolyl cis peptide bond; other site 1303024002869 insertion regions; other site 1303024002870 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1303024002871 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1303024002872 active site 1303024002873 substrate binding site [chemical binding]; other site 1303024002874 cosubstrate binding site; other site 1303024002875 catalytic site [active] 1303024002876 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1303024002877 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1303024002878 purine monophosphate binding site [chemical binding]; other site 1303024002879 dimer interface [polypeptide binding]; other site 1303024002880 putative catalytic residues [active] 1303024002881 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1303024002882 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1303024002883 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1303024002884 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1303024002885 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1303024002886 Cupin domain; Region: Cupin_2; cl17218 1303024002887 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1303024002888 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1303024002889 enoyl-CoA hydratase; Provisional; Region: PRK07827 1303024002890 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024002891 substrate binding site [chemical binding]; other site 1303024002892 oxyanion hole (OAH) forming residues; other site 1303024002893 trimer interface [polypeptide binding]; other site 1303024002894 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024002895 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1303024002896 active site 1303024002897 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1303024002898 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1303024002899 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1303024002900 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1303024002901 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1303024002902 carboxyltransferase (CT) interaction site; other site 1303024002903 biotinylation site [posttranslational modification]; other site 1303024002904 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1303024002905 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1303024002906 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024002907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024002908 active site 1303024002909 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1303024002910 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1303024002911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024002912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024002913 active site 1303024002914 phosphorylation site [posttranslational modification] 1303024002915 intermolecular recognition site; other site 1303024002916 dimerization interface [polypeptide binding]; other site 1303024002917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024002918 DNA binding site [nucleotide binding] 1303024002919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024002920 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1303024002921 dimerization interface [polypeptide binding]; other site 1303024002922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024002923 dimer interface [polypeptide binding]; other site 1303024002924 phosphorylation site [posttranslational modification] 1303024002925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024002926 ATP binding site [chemical binding]; other site 1303024002927 Mg2+ binding site [ion binding]; other site 1303024002928 G-X-G motif; other site 1303024002929 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1303024002930 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1303024002931 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1303024002932 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1303024002933 MPT binding site; other site 1303024002934 trimer interface [polypeptide binding]; other site 1303024002935 MspA; Region: MspA; pfam09203 1303024002936 MspA; Region: MspA; pfam09203 1303024002937 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1303024002938 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1303024002939 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1303024002940 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1303024002941 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1303024002942 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1303024002943 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1303024002944 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1303024002945 active site 1303024002946 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1303024002947 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1303024002948 dimer interface [polypeptide binding]; other site 1303024002949 putative functional site; other site 1303024002950 putative MPT binding site; other site 1303024002951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1303024002952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1303024002953 integrase; Provisional; Region: int; PHA02601 1303024002954 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024002955 active site 1303024002956 DNA binding site [nucleotide binding] 1303024002957 Int/Topo IB signature motif; other site 1303024002958 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1303024002959 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1303024002960 catalytic residues [active] 1303024002961 catalytic nucleophile [active] 1303024002962 Presynaptic Site I dimer interface [polypeptide binding]; other site 1303024002963 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1303024002964 Synaptic Flat tetramer interface [polypeptide binding]; other site 1303024002965 Synaptic Site I dimer interface [polypeptide binding]; other site 1303024002966 DNA binding site [nucleotide binding] 1303024002967 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1303024002968 DNA-binding interface [nucleotide binding]; DNA binding site 1303024002969 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1303024002970 MT-A70; Region: MT-A70; cl01947 1303024002971 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1303024002972 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1303024002973 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1303024002974 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1303024002975 D5 N terminal like; Region: D5_N; pfam08706 1303024002976 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1303024002977 Cupin domain; Region: Cupin_2; cl17218 1303024002978 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024002979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024002980 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1303024002981 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1303024002982 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1303024002983 NAD(P) binding site [chemical binding]; other site 1303024002984 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024002985 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024002986 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024002987 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 1303024002988 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024002989 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024002990 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1303024002991 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1303024002992 arginine deiminase; Provisional; Region: PRK01388 1303024002993 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1303024002994 Predicted methyltransferases [General function prediction only]; Region: COG0313 1303024002995 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1303024002996 putative SAM binding site [chemical binding]; other site 1303024002997 putative homodimer interface [polypeptide binding]; other site 1303024002998 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1303024002999 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1303024003000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024003001 Coenzyme A binding pocket [chemical binding]; other site 1303024003002 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1303024003003 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024003004 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1303024003005 DNA binding residues [nucleotide binding] 1303024003006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1303024003007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024003008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024003009 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1303024003010 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1303024003011 active site 1303024003012 HIGH motif; other site 1303024003013 KMSKS motif; other site 1303024003014 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1303024003015 tRNA binding surface [nucleotide binding]; other site 1303024003016 anticodon binding site; other site 1303024003017 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1303024003018 active site 1303024003019 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1303024003020 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1303024003021 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1303024003022 G5 domain; Region: G5; pfam07501 1303024003023 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1303024003024 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1303024003025 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1303024003026 L-asparagine permease; Provisional; Region: PRK15049 1303024003027 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1303024003028 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1303024003029 active site 1303024003030 ATP binding site [chemical binding]; other site 1303024003031 substrate binding site [chemical binding]; other site 1303024003032 activation loop (A-loop); other site 1303024003033 Transport protein; Region: actII; TIGR00833 1303024003034 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024003035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024003036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003037 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1303024003038 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1303024003039 putative acetyltransferase; Provisional; Region: PRK03624 1303024003040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024003041 Coenzyme A binding pocket [chemical binding]; other site 1303024003042 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1303024003043 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1303024003044 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1303024003045 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1303024003046 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1303024003047 acyl-activating enzyme (AAE) consensus motif; other site 1303024003048 active site 1303024003049 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1303024003050 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1303024003051 dimer interface [polypeptide binding]; other site 1303024003052 active site 1303024003053 CoA binding pocket [chemical binding]; other site 1303024003054 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1303024003055 putative active site [active] 1303024003056 catalytic residue [active] 1303024003057 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1303024003058 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1303024003059 5S rRNA interface [nucleotide binding]; other site 1303024003060 CTC domain interface [polypeptide binding]; other site 1303024003061 L16 interface [polypeptide binding]; other site 1303024003062 short chain dehydrogenase; Provisional; Region: PRK06197 1303024003063 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1303024003064 putative NAD(P) binding site [chemical binding]; other site 1303024003065 active site 1303024003066 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1303024003067 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1303024003068 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1303024003069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1303024003070 active site 1303024003071 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1303024003072 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1303024003073 Substrate binding site; other site 1303024003074 Mg++ binding site; other site 1303024003075 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1303024003076 active site 1303024003077 substrate binding site [chemical binding]; other site 1303024003078 CoA binding site [chemical binding]; other site 1303024003079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024003080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003081 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1303024003082 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1303024003083 active site 1303024003084 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1303024003085 substrate binding site [chemical binding]; other site 1303024003086 catalytic residues [active] 1303024003087 dimer interface [polypeptide binding]; other site 1303024003088 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1303024003089 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1303024003090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024003091 ATP binding site [chemical binding]; other site 1303024003092 putative Mg++ binding site [ion binding]; other site 1303024003093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024003094 nucleotide binding region [chemical binding]; other site 1303024003095 ATP-binding site [chemical binding]; other site 1303024003096 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1303024003097 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1303024003098 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1303024003099 homodimer interface [polypeptide binding]; other site 1303024003100 metal binding site [ion binding]; metal-binding site 1303024003101 Iron permease FTR1 family; Region: FTR1; cl00475 1303024003102 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1303024003103 Imelysin; Region: Peptidase_M75; cl09159 1303024003104 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1303024003105 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1303024003106 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1303024003107 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1303024003108 Imelysin; Region: Peptidase_M75; pfam09375 1303024003109 Iron permease FTR1 family; Region: FTR1; cl00475 1303024003110 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1303024003111 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1303024003112 enolase; Provisional; Region: eno; PRK00077 1303024003113 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1303024003114 dimer interface [polypeptide binding]; other site 1303024003115 metal binding site [ion binding]; metal-binding site 1303024003116 substrate binding pocket [chemical binding]; other site 1303024003117 Septum formation initiator; Region: DivIC; pfam04977 1303024003118 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1303024003119 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1303024003120 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1303024003121 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1303024003122 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1303024003123 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1303024003124 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1303024003125 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1303024003126 acyl-activating enzyme (AAE) consensus motif; other site 1303024003127 active site 1303024003128 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 1303024003129 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1303024003130 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1303024003131 LGFP repeat; Region: LGFP; pfam08310 1303024003132 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1303024003133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1303024003134 active site residue [active] 1303024003135 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024003136 MarR family; Region: MarR; pfam01047 1303024003137 enoyl-CoA hydratase; Provisional; Region: PRK05862 1303024003138 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024003139 substrate binding site [chemical binding]; other site 1303024003140 oxyanion hole (OAH) forming residues; other site 1303024003141 trimer interface [polypeptide binding]; other site 1303024003142 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1303024003143 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1303024003144 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1303024003145 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024003146 substrate binding site [chemical binding]; other site 1303024003147 oxyanion hole (OAH) forming residues; other site 1303024003148 trimer interface [polypeptide binding]; other site 1303024003149 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1303024003150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024003151 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1303024003152 substrate binding pocket [chemical binding]; other site 1303024003153 FAD binding site [chemical binding]; other site 1303024003154 catalytic base [active] 1303024003155 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1303024003156 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1303024003157 tetrameric interface [polypeptide binding]; other site 1303024003158 NAD binding site [chemical binding]; other site 1303024003159 catalytic residues [active] 1303024003160 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1303024003161 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1303024003162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024003163 ATP-grasp domain; Region: ATP-grasp; pfam02222 1303024003164 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1303024003165 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1303024003166 dimer interface [polypeptide binding]; other site 1303024003167 active site 1303024003168 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1303024003169 active site 1303024003170 catalytic triad [active] 1303024003171 oxyanion hole [active] 1303024003172 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1303024003173 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024003174 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1303024003175 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1303024003176 dimer interface [polypeptide binding]; other site 1303024003177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024003178 catalytic residue [active] 1303024003179 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1303024003180 RDD family; Region: RDD; pfam06271 1303024003181 cystathionine gamma-synthase; Provisional; Region: PRK07811 1303024003182 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1303024003183 homodimer interface [polypeptide binding]; other site 1303024003184 substrate-cofactor binding pocket; other site 1303024003185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024003186 catalytic residue [active] 1303024003187 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1303024003188 threonine dehydratase; Provisional; Region: PRK08198 1303024003189 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1303024003190 tetramer interface [polypeptide binding]; other site 1303024003191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024003192 catalytic residue [active] 1303024003193 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1303024003194 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1303024003195 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1303024003196 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1303024003197 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1303024003198 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1303024003199 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1303024003200 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1303024003201 catalytic residues [active] 1303024003202 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1303024003203 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1303024003204 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1303024003205 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1303024003206 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1303024003207 catalytic residue [active] 1303024003208 putative FPP diphosphate binding site; other site 1303024003209 putative FPP binding hydrophobic cleft; other site 1303024003210 dimer interface [polypeptide binding]; other site 1303024003211 putative IPP diphosphate binding site; other site 1303024003212 classical (c) SDRs; Region: SDR_c; cd05233 1303024003213 short chain dehydrogenase; Provisional; Region: PRK12939 1303024003214 NAD(P) binding site [chemical binding]; other site 1303024003215 active site 1303024003216 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024003217 Cytochrome P450; Region: p450; cl12078 1303024003218 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1303024003219 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1303024003220 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024003221 Cytochrome P450; Region: p450; cl12078 1303024003222 short chain dehydrogenase; Provisional; Region: PRK07775 1303024003223 classical (c) SDRs; Region: SDR_c; cd05233 1303024003224 NAD(P) binding site [chemical binding]; other site 1303024003225 active site 1303024003226 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024003227 Cytochrome P450; Region: p450; cl12078 1303024003228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024003229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003230 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1303024003231 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1303024003232 NAD binding site [chemical binding]; other site 1303024003233 catalytic residues [active] 1303024003234 short chain dehydrogenase; Provisional; Region: PRK07774 1303024003235 classical (c) SDRs; Region: SDR_c; cd05233 1303024003236 NAD(P) binding site [chemical binding]; other site 1303024003237 active site 1303024003238 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1303024003239 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1303024003240 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1303024003241 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1303024003242 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024003243 substrate binding pocket [chemical binding]; other site 1303024003244 catalytic triad [active] 1303024003245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024003246 putative PBP binding loops; other site 1303024003247 dimer interface [polypeptide binding]; other site 1303024003248 ABC-ATPase subunit interface; other site 1303024003249 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1303024003250 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1303024003251 Walker A/P-loop; other site 1303024003252 ATP binding site [chemical binding]; other site 1303024003253 Q-loop/lid; other site 1303024003254 ABC transporter signature motif; other site 1303024003255 Walker B; other site 1303024003256 D-loop; other site 1303024003257 H-loop/switch region; other site 1303024003258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024003259 ABC-ATPase subunit interface; other site 1303024003260 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1303024003261 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1303024003262 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1303024003263 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1303024003264 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1303024003265 SnoaL-like domain; Region: SnoaL_2; pfam12680 1303024003266 pantothenate kinase; Provisional; Region: PRK05439 1303024003267 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1303024003268 ATP-binding site [chemical binding]; other site 1303024003269 CoA-binding site [chemical binding]; other site 1303024003270 Mg2+-binding site [ion binding]; other site 1303024003271 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1303024003272 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1303024003273 dimer interface [polypeptide binding]; other site 1303024003274 active site 1303024003275 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1303024003276 folate binding site [chemical binding]; other site 1303024003277 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1303024003278 dinuclear metal binding motif [ion binding]; other site 1303024003279 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1303024003280 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1303024003281 putative active site [active] 1303024003282 PhoH-like protein; Region: PhoH; pfam02562 1303024003283 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1303024003284 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1303024003285 NodB motif; other site 1303024003286 active site 1303024003287 catalytic site [active] 1303024003288 metal binding site [ion binding]; metal-binding site 1303024003289 CsbD-like; Region: CsbD; pfam05532 1303024003290 Asp23 family; Region: Asp23; pfam03780 1303024003291 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1303024003292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024003293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024003294 DNA binding residues [nucleotide binding] 1303024003295 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1303024003296 Class II fumarases; Region: Fumarase_classII; cd01362 1303024003297 active site 1303024003298 tetramer interface [polypeptide binding]; other site 1303024003299 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1303024003300 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1303024003301 putative active site [active] 1303024003302 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1303024003303 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1303024003304 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1303024003305 dimer interface [polypeptide binding]; other site 1303024003306 active site 1303024003307 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1303024003308 substrate binding site [chemical binding]; other site 1303024003309 catalytic residue [active] 1303024003310 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1303024003311 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1303024003312 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1303024003313 generic binding surface II; other site 1303024003314 generic binding surface I; other site 1303024003315 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1303024003316 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1303024003317 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1303024003318 carbon starvation protein A; Provisional; Region: PRK15015 1303024003319 Carbon starvation protein CstA; Region: CstA; pfam02554 1303024003320 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1303024003321 PspC domain; Region: PspC; pfam04024 1303024003322 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1303024003323 GTP-binding protein YchF; Reviewed; Region: PRK09601 1303024003324 YchF GTPase; Region: YchF; cd01900 1303024003325 G1 box; other site 1303024003326 GTP/Mg2+ binding site [chemical binding]; other site 1303024003327 Switch I region; other site 1303024003328 G2 box; other site 1303024003329 Switch II region; other site 1303024003330 G3 box; other site 1303024003331 G4 box; other site 1303024003332 G5 box; other site 1303024003333 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1303024003334 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1303024003335 active site 1303024003336 metal binding site [ion binding]; metal-binding site 1303024003337 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1303024003338 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1303024003339 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1303024003340 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1303024003341 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1303024003342 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1303024003343 dimer interface [polypeptide binding]; other site 1303024003344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024003345 catalytic residue [active] 1303024003346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024003347 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024003348 putative substrate translocation pore; other site 1303024003349 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1303024003350 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024003351 ABC transporter; Region: ABC_tran_2; pfam12848 1303024003352 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024003353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1303024003354 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024003355 Predicted membrane protein [Function unknown]; Region: COG2259 1303024003356 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1303024003357 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1303024003358 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1303024003359 dimer interface [polypeptide binding]; other site 1303024003360 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1303024003361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024003362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003363 WHG domain; Region: WHG; pfam13305 1303024003364 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1303024003365 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1303024003366 dimer interface [polypeptide binding]; other site 1303024003367 catalytic triad [active] 1303024003368 peroxidatic and resolving cysteines [active] 1303024003369 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024003370 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1303024003371 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024003372 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1303024003373 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1303024003374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024003375 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024003376 S-adenosylmethionine binding site [chemical binding]; other site 1303024003377 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024003378 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1303024003379 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1303024003380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024003381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024003382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1303024003383 minor groove reading motif; other site 1303024003384 helix-hairpin-helix signature motif; other site 1303024003385 mannosyltransferase; Provisional; Region: pimE; PRK13375 1303024003386 short chain dehydrogenase; Provisional; Region: PRK06179 1303024003387 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1303024003388 NADP binding site [chemical binding]; other site 1303024003389 active site 1303024003390 steroid binding site; other site 1303024003391 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1303024003392 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1303024003393 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1303024003394 putative active site [active] 1303024003395 putative substrate binding site [chemical binding]; other site 1303024003396 putative cosubstrate binding site; other site 1303024003397 catalytic site [active] 1303024003398 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1303024003399 aromatic arch; other site 1303024003400 DCoH dimer interaction site [polypeptide binding]; other site 1303024003401 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1303024003402 DCoH tetramer interaction site [polypeptide binding]; other site 1303024003403 substrate binding site [chemical binding]; other site 1303024003404 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1303024003405 active site 1303024003406 8-oxo-dGMP binding site [chemical binding]; other site 1303024003407 nudix motif; other site 1303024003408 metal binding site [ion binding]; metal-binding site 1303024003409 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1303024003410 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1303024003411 G1 box; other site 1303024003412 putative GEF interaction site [polypeptide binding]; other site 1303024003413 GTP/Mg2+ binding site [chemical binding]; other site 1303024003414 Switch I region; other site 1303024003415 G2 box; other site 1303024003416 G3 box; other site 1303024003417 Switch II region; other site 1303024003418 G4 box; other site 1303024003419 G5 box; other site 1303024003420 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1303024003421 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1303024003422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024003423 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1303024003424 active site 1303024003425 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1303024003426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024003427 SCP-2 sterol transfer family; Region: SCP2; cl01225 1303024003428 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1303024003429 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1303024003430 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1303024003431 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1303024003432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024003433 S-adenosylmethionine binding site [chemical binding]; other site 1303024003434 FO synthase; Reviewed; Region: fbiC; PRK09234 1303024003435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024003436 FeS/SAM binding site; other site 1303024003437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024003438 FeS/SAM binding site; other site 1303024003439 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1303024003440 MspA; Region: MspA; pfam09203 1303024003441 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1303024003442 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1303024003443 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1303024003444 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1303024003445 active site 1303024003446 FMN binding site [chemical binding]; other site 1303024003447 2,4-decadienoyl-CoA binding site; other site 1303024003448 catalytic residue [active] 1303024003449 4Fe-4S cluster binding site [ion binding]; other site 1303024003450 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1303024003451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024003452 Predicted transcriptional regulators [Transcription]; Region: COG1695 1303024003453 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1303024003454 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1303024003455 Ferredoxin [Energy production and conversion]; Region: COG1146 1303024003456 4Fe-4S binding domain; Region: Fer4; pfam00037 1303024003457 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1303024003458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024003459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024003460 homodimer interface [polypeptide binding]; other site 1303024003461 catalytic residue [active] 1303024003462 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1303024003463 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1303024003464 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1303024003465 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1303024003466 Glutamate binding site [chemical binding]; other site 1303024003467 NAD binding site [chemical binding]; other site 1303024003468 catalytic residues [active] 1303024003469 Proline dehydrogenase; Region: Pro_dh; cl03282 1303024003470 acyl-CoA synthetase; Validated; Region: PRK07787 1303024003471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024003472 acyl-activating enzyme (AAE) consensus motif; other site 1303024003473 AMP binding site [chemical binding]; other site 1303024003474 active site 1303024003475 CoA binding site [chemical binding]; other site 1303024003476 DinB superfamily; Region: DinB_2; pfam12867 1303024003477 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1303024003478 active site 1303024003479 catalytic triad [active] 1303024003480 oxyanion hole [active] 1303024003481 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1303024003482 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1303024003483 putative trimer interface [polypeptide binding]; other site 1303024003484 putative CoA binding site [chemical binding]; other site 1303024003485 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1303024003486 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1303024003487 metal binding site [ion binding]; metal-binding site 1303024003488 putative dimer interface [polypeptide binding]; other site 1303024003489 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1303024003490 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1303024003491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024003492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024003493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024003494 putative substrate translocation pore; other site 1303024003495 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1303024003496 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024003497 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1303024003498 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1303024003499 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1303024003500 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1303024003501 acyl-activating enzyme (AAE) consensus motif; other site 1303024003502 putative AMP binding site [chemical binding]; other site 1303024003503 putative active site [active] 1303024003504 putative CoA binding site [chemical binding]; other site 1303024003505 HNH endonuclease; Region: HNH; pfam01844 1303024003506 active site 1303024003507 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1303024003508 extended (e) SDRs; Region: SDR_e; cd08946 1303024003509 NAD(P) binding site [chemical binding]; other site 1303024003510 active site 1303024003511 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1303024003512 dihydropteroate synthase; Region: DHPS; TIGR01496 1303024003513 substrate binding pocket [chemical binding]; other site 1303024003514 dimer interface [polypeptide binding]; other site 1303024003515 inhibitor binding site; inhibition site 1303024003516 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1303024003517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1303024003518 active site 1303024003519 DivIVA domain; Region: DivI1A_domain; TIGR03544 1303024003520 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1303024003521 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1303024003522 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1303024003523 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1303024003524 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1303024003525 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1303024003526 ligand binding site; other site 1303024003527 oligomer interface; other site 1303024003528 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1303024003529 dimer interface [polypeptide binding]; other site 1303024003530 N-terminal domain interface [polypeptide binding]; other site 1303024003531 sulfate 1 binding site; other site 1303024003532 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1303024003533 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1303024003534 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1303024003535 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1303024003536 Walker A/P-loop; other site 1303024003537 ATP binding site [chemical binding]; other site 1303024003538 Q-loop/lid; other site 1303024003539 ABC transporter signature motif; other site 1303024003540 Walker B; other site 1303024003541 D-loop; other site 1303024003542 H-loop/switch region; other site 1303024003543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024003544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003545 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1303024003546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024003547 S-adenosylmethionine binding site [chemical binding]; other site 1303024003548 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1303024003549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024003550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024003551 DNA binding residues [nucleotide binding] 1303024003552 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1303024003553 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1303024003554 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1303024003555 protein binding site [polypeptide binding]; other site 1303024003556 sec-independent translocase; Provisional; Region: PRK03100 1303024003557 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1303024003558 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1303024003559 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1303024003560 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1303024003561 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1303024003562 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1303024003563 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1303024003564 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1303024003565 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1303024003566 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1303024003567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024003568 dimer interface [polypeptide binding]; other site 1303024003569 conserved gate region; other site 1303024003570 putative PBP binding loops; other site 1303024003571 ABC-ATPase subunit interface; other site 1303024003572 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1303024003573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024003574 dimer interface [polypeptide binding]; other site 1303024003575 conserved gate region; other site 1303024003576 putative PBP binding loops; other site 1303024003577 ABC-ATPase subunit interface; other site 1303024003578 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1303024003579 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1303024003580 Walker A/P-loop; other site 1303024003581 ATP binding site [chemical binding]; other site 1303024003582 Q-loop/lid; other site 1303024003583 ABC transporter signature motif; other site 1303024003584 Walker B; other site 1303024003585 D-loop; other site 1303024003586 H-loop/switch region; other site 1303024003587 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1303024003588 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1303024003589 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1303024003590 oligomer interface [polypeptide binding]; other site 1303024003591 metal binding site [ion binding]; metal-binding site 1303024003592 metal binding site [ion binding]; metal-binding site 1303024003593 putative Cl binding site [ion binding]; other site 1303024003594 basic sphincter; other site 1303024003595 hydrophobic gate; other site 1303024003596 periplasmic entrance; other site 1303024003597 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1303024003598 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1303024003599 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1303024003600 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1303024003601 putative NAD(P) binding site [chemical binding]; other site 1303024003602 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1303024003603 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024003604 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024003605 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024003606 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024003607 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1303024003608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024003609 NAD(P) binding site [chemical binding]; other site 1303024003610 active site 1303024003611 classical (c) SDRs; Region: SDR_c; cd05233 1303024003612 short chain dehydrogenase; Provisional; Region: PRK05650 1303024003613 NAD(P) binding site [chemical binding]; other site 1303024003614 active site 1303024003615 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024003616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024003617 S-adenosylmethionine binding site [chemical binding]; other site 1303024003618 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024003619 Secretory lipase; Region: LIP; pfam03583 1303024003620 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1303024003621 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1303024003622 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1303024003623 TPP-binding site [chemical binding]; other site 1303024003624 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1303024003625 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1303024003626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024003627 putative substrate translocation pore; other site 1303024003628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024003629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024003630 putative substrate translocation pore; other site 1303024003631 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1303024003632 FAD binding domain; Region: FAD_binding_4; pfam01565 1303024003633 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1303024003634 active site 1303024003635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003636 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1303024003637 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1303024003638 RNase_H superfamily; Region: RNase_H_2; pfam13482 1303024003639 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1303024003640 Part of AAA domain; Region: AAA_19; pfam13245 1303024003641 AAA domain; Region: AAA_12; pfam13087 1303024003642 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1303024003643 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1303024003644 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1303024003645 ATP binding site [chemical binding]; other site 1303024003646 Mg++ binding site [ion binding]; other site 1303024003647 motif III; other site 1303024003648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024003649 nucleotide binding region [chemical binding]; other site 1303024003650 ATP-binding site [chemical binding]; other site 1303024003651 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1303024003652 putative RNA binding site [nucleotide binding]; other site 1303024003653 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1303024003654 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024003655 Cytochrome P450; Region: p450; cl12078 1303024003656 FAD binding domain; Region: FAD_binding_4; pfam01565 1303024003657 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1303024003658 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1303024003659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024003660 NAD(P) binding site [chemical binding]; other site 1303024003661 active site 1303024003662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024003663 H+ Antiporter protein; Region: 2A0121; TIGR00900 1303024003664 putative substrate translocation pore; other site 1303024003665 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1303024003666 HIT family signature motif; other site 1303024003667 catalytic residue [active] 1303024003668 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1303024003669 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1303024003670 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1303024003671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1303024003672 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1303024003673 Walker A/P-loop; other site 1303024003674 ATP binding site [chemical binding]; other site 1303024003675 Q-loop/lid; other site 1303024003676 ABC transporter signature motif; other site 1303024003677 Walker B; other site 1303024003678 D-loop; other site 1303024003679 H-loop/switch region; other site 1303024003680 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1303024003681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1303024003682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024003683 Walker A/P-loop; other site 1303024003684 ATP binding site [chemical binding]; other site 1303024003685 Q-loop/lid; other site 1303024003686 ABC transporter signature motif; other site 1303024003687 Walker B; other site 1303024003688 D-loop; other site 1303024003689 H-loop/switch region; other site 1303024003690 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1303024003691 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1303024003692 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1303024003693 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024003694 catalytic core [active] 1303024003695 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1303024003696 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1303024003697 active site 1303024003698 metal binding site [ion binding]; metal-binding site 1303024003699 DNA binding site [nucleotide binding] 1303024003700 AAA ATPase domain; Region: AAA_15; pfam13175 1303024003701 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1303024003702 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1303024003703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024003704 active site 1303024003705 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1303024003706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003707 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024003708 Cytochrome P450; Region: p450; cl12078 1303024003709 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024003710 Cytochrome P450; Region: p450; cl12078 1303024003711 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1303024003712 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1303024003713 putative active site [active] 1303024003714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024003715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024003716 putative substrate translocation pore; other site 1303024003717 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1303024003718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003719 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1303024003720 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024003721 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1303024003722 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1303024003723 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1303024003724 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1303024003725 active site 1303024003726 HIGH motif; other site 1303024003727 KMSK motif region; other site 1303024003728 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1303024003729 tRNA binding surface [nucleotide binding]; other site 1303024003730 anticodon binding site; other site 1303024003731 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1303024003732 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1303024003733 active site 1303024003734 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1303024003735 substrate binding site [chemical binding]; other site 1303024003736 catalytic residues [active] 1303024003737 dimer interface [polypeptide binding]; other site 1303024003738 homoserine dehydrogenase; Provisional; Region: PRK06349 1303024003739 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1303024003740 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1303024003741 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1303024003742 threonine synthase; Reviewed; Region: PRK06721 1303024003743 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1303024003744 homodimer interface [polypeptide binding]; other site 1303024003745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024003746 catalytic residue [active] 1303024003747 homoserine kinase; Provisional; Region: PRK01212 1303024003748 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1303024003749 transcription termination factor Rho; Provisional; Region: PRK12608 1303024003750 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1303024003751 RNA binding site [nucleotide binding]; other site 1303024003752 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1303024003753 multimer interface [polypeptide binding]; other site 1303024003754 Walker A motif; other site 1303024003755 ATP binding site [chemical binding]; other site 1303024003756 Walker B motif; other site 1303024003757 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1303024003758 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1303024003759 PCRF domain; Region: PCRF; pfam03462 1303024003760 RF-1 domain; Region: RF-1; pfam00472 1303024003761 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1303024003762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024003763 S-adenosylmethionine binding site [chemical binding]; other site 1303024003764 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1303024003765 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1303024003766 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1303024003767 Mg++ binding site [ion binding]; other site 1303024003768 putative catalytic motif [active] 1303024003769 substrate binding site [chemical binding]; other site 1303024003770 Tic20-like protein; Region: Tic20; pfam09685 1303024003771 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1303024003772 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1303024003773 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1303024003774 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1303024003775 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1303024003776 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1303024003777 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1303024003778 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1303024003779 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1303024003780 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1303024003781 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1303024003782 beta subunit interaction interface [polypeptide binding]; other site 1303024003783 Walker A motif; other site 1303024003784 ATP binding site [chemical binding]; other site 1303024003785 Walker B motif; other site 1303024003786 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1303024003787 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1303024003788 core domain interface [polypeptide binding]; other site 1303024003789 delta subunit interface [polypeptide binding]; other site 1303024003790 epsilon subunit interface [polypeptide binding]; other site 1303024003791 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1303024003792 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1303024003793 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1303024003794 alpha subunit interaction interface [polypeptide binding]; other site 1303024003795 Walker A motif; other site 1303024003796 ATP binding site [chemical binding]; other site 1303024003797 Walker B motif; other site 1303024003798 inhibitor binding site; inhibition site 1303024003799 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1303024003800 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1303024003801 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1303024003802 gamma subunit interface [polypeptide binding]; other site 1303024003803 epsilon subunit interface [polypeptide binding]; other site 1303024003804 LBP interface [polypeptide binding]; other site 1303024003805 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1303024003806 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1303024003807 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1303024003808 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1303024003809 hinge; other site 1303024003810 active site 1303024003811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1303024003812 dimerization interface [polypeptide binding]; other site 1303024003813 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1303024003814 cyclase homology domain; Region: CHD; cd07302 1303024003815 nucleotidyl binding site; other site 1303024003816 metal binding site [ion binding]; metal-binding site 1303024003817 dimer interface [polypeptide binding]; other site 1303024003818 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1303024003819 hypothetical protein; Provisional; Region: PRK03298 1303024003820 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1303024003821 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024003822 dimer interface [polypeptide binding]; other site 1303024003823 substrate binding site [chemical binding]; other site 1303024003824 metal binding site [ion binding]; metal-binding site 1303024003825 putative acyltransferase; Provisional; Region: PRK05790 1303024003826 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1303024003827 dimer interface [polypeptide binding]; other site 1303024003828 active site 1303024003829 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1303024003830 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1303024003831 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1303024003832 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1303024003833 glycogen branching enzyme; Provisional; Region: PRK05402 1303024003834 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1303024003835 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1303024003836 active site 1303024003837 catalytic site [active] 1303024003838 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1303024003839 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1303024003840 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1303024003841 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1303024003842 active site 1303024003843 homodimer interface [polypeptide binding]; other site 1303024003844 catalytic site [active] 1303024003845 acceptor binding site [chemical binding]; other site 1303024003846 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1303024003847 putative homodimer interface [polypeptide binding]; other site 1303024003848 putative active site pocket [active] 1303024003849 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1303024003850 Predicted metalloprotease [General function prediction only]; Region: COG2321 1303024003851 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1303024003852 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1303024003853 ATP binding site [chemical binding]; other site 1303024003854 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1303024003855 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1303024003856 Isochorismatase family; Region: Isochorismatase; pfam00857 1303024003857 catalytic triad [active] 1303024003858 metal binding site [ion binding]; metal-binding site 1303024003859 conserved cis-peptide bond; other site 1303024003860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024003861 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1303024003862 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1303024003863 active site 1303024003864 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1303024003865 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1303024003866 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1303024003867 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1303024003868 cleavage site 1303024003869 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1303024003870 MPN+ (JAMM) motif; other site 1303024003871 Zinc-binding site [ion binding]; other site 1303024003872 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1303024003873 MoaE interaction surface [polypeptide binding]; other site 1303024003874 MoeB interaction surface [polypeptide binding]; other site 1303024003875 thiocarboxylated glycine; other site 1303024003876 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1303024003877 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1303024003878 dimer interface [polypeptide binding]; other site 1303024003879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024003880 catalytic residue [active] 1303024003881 Rhomboid family; Region: Rhomboid; pfam01694 1303024003882 glutamate racemase; Provisional; Region: PRK00865 1303024003883 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1303024003884 ribonuclease PH; Reviewed; Region: rph; PRK00173 1303024003885 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1303024003886 hexamer interface [polypeptide binding]; other site 1303024003887 active site 1303024003888 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1303024003889 active site 1303024003890 dimerization interface [polypeptide binding]; other site 1303024003891 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1303024003892 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1303024003893 putative NAD(P) binding site [chemical binding]; other site 1303024003894 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1303024003895 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1303024003896 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1303024003897 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1303024003898 acyl-activating enzyme (AAE) consensus motif; other site 1303024003899 active site 1303024003900 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1303024003901 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1303024003902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1303024003903 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1303024003904 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1303024003905 enoyl-CoA hydratase; Provisional; Region: PRK06563 1303024003906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024003907 substrate binding site [chemical binding]; other site 1303024003908 oxyanion hole (OAH) forming residues; other site 1303024003909 trimer interface [polypeptide binding]; other site 1303024003910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024003911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003912 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1303024003913 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1303024003914 molybdopterin cofactor binding site; other site 1303024003915 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1303024003916 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1303024003917 putative molybdopterin cofactor binding site; other site 1303024003918 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024003919 hypothetical protein; Provisional; Region: PRK06184 1303024003920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024003921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003922 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1303024003923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024003924 DNA-binding site [nucleotide binding]; DNA binding site 1303024003925 UTRA domain; Region: UTRA; pfam07702 1303024003926 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1303024003927 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1303024003928 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1303024003929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024003930 motif II; other site 1303024003931 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1303024003932 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1303024003933 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1303024003934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024003935 Walker A/P-loop; other site 1303024003936 ATP binding site [chemical binding]; other site 1303024003937 Q-loop/lid; other site 1303024003938 ABC transporter signature motif; other site 1303024003939 Walker B; other site 1303024003940 D-loop; other site 1303024003941 H-loop/switch region; other site 1303024003942 TOBE domain; Region: TOBE_2; pfam08402 1303024003943 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1303024003944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024003945 dimer interface [polypeptide binding]; other site 1303024003946 conserved gate region; other site 1303024003947 putative PBP binding loops; other site 1303024003948 ABC-ATPase subunit interface; other site 1303024003949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024003950 dimer interface [polypeptide binding]; other site 1303024003951 conserved gate region; other site 1303024003952 putative PBP binding loops; other site 1303024003953 ABC-ATPase subunit interface; other site 1303024003954 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1303024003955 putative active site [active] 1303024003956 putative catalytic site [active] 1303024003957 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024003958 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1303024003959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003960 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1303024003961 Predicted membrane protein [Function unknown]; Region: COG4425 1303024003962 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1303024003963 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024003964 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1303024003965 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1303024003966 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1303024003967 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1303024003968 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1303024003969 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1303024003970 phosphate binding site [ion binding]; other site 1303024003971 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1303024003972 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1303024003973 putative active site [active] 1303024003974 putative catalytic site [active] 1303024003975 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1303024003976 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1303024003977 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1303024003978 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1303024003979 putative NAD(P) binding site [chemical binding]; other site 1303024003980 active site 1303024003981 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1303024003982 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1303024003983 active site 1303024003984 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1303024003985 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1303024003986 nudix motif; other site 1303024003987 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1303024003988 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1303024003989 catalytic triad [active] 1303024003990 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1303024003991 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024003992 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1303024003993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024003994 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 1303024003995 Transport protein; Region: actII; TIGR00833 1303024003996 Histidine kinase; Region: HisKA_3; pfam07730 1303024003997 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1303024003998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024003999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024004000 active site 1303024004001 phosphorylation site [posttranslational modification] 1303024004002 intermolecular recognition site; other site 1303024004003 dimerization interface [polypeptide binding]; other site 1303024004004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024004005 DNA binding residues [nucleotide binding] 1303024004006 dimerization interface [polypeptide binding]; other site 1303024004007 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1303024004008 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1303024004009 MgtE intracellular N domain; Region: MgtE_N; smart00924 1303024004010 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1303024004011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024004012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004013 short chain dehydrogenase; Provisional; Region: PRK07825 1303024004014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024004015 NAD(P) binding site [chemical binding]; other site 1303024004016 active site 1303024004017 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024004018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024004019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024004020 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1303024004021 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1303024004022 active site 1303024004023 catalytic tetrad [active] 1303024004024 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1303024004025 active site 1303024004026 catalytic site [active] 1303024004027 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024004028 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1303024004029 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024004030 active site 1303024004031 DNA binding site [nucleotide binding] 1303024004032 Int/Topo IB signature motif; other site 1303024004033 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1303024004034 Domain of unknown function (DUF955); Region: DUF955; cl01076 1303024004035 LabA_like proteins; Region: LabA_like; cd06167 1303024004036 putative metal binding site [ion binding]; other site 1303024004037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1303024004038 DNA binding residues [nucleotide binding] 1303024004039 Helix-turn-helix domain; Region: HTH_17; cl17695 1303024004040 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1303024004041 ERF superfamily; Region: ERF; pfam04404 1303024004042 putative transposase OrfB; Reviewed; Region: PHA02517 1303024004043 HTH-like domain; Region: HTH_21; pfam13276 1303024004044 Integrase core domain; Region: rve; pfam00665 1303024004045 Integrase core domain; Region: rve_3; pfam13683 1303024004046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024004047 Transposase; Region: HTH_Tnp_1; cl17663 1303024004048 Transcription factor WhiB; Region: Whib; pfam02467 1303024004049 Transcription factor WhiB; Region: Whib; pfam02467 1303024004050 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 1303024004051 HicB family; Region: HicB; pfam05534 1303024004052 HNH endonuclease; Region: HNH_3; pfam13392 1303024004053 putative transposase OrfB; Reviewed; Region: PHA02517 1303024004054 HTH-like domain; Region: HTH_21; pfam13276 1303024004055 Integrase core domain; Region: rve; pfam00665 1303024004056 Integrase core domain; Region: rve_3; cl15866 1303024004057 Transposase; Region: HTH_Tnp_1; cl17663 1303024004058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024004059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1303024004060 active site 1303024004061 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1303024004062 putative transposase OrfB; Reviewed; Region: PHA02517 1303024004063 HTH-like domain; Region: HTH_21; pfam13276 1303024004064 Integrase core domain; Region: rve; pfam00665 1303024004065 Integrase core domain; Region: rve_3; pfam13683 1303024004066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024004067 Transposase; Region: HTH_Tnp_1; cl17663 1303024004068 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1303024004069 active site 1303024004070 Transposase; Region: HTH_Tnp_1; cl17663 1303024004071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024004072 putative transposase OrfB; Reviewed; Region: PHA02517 1303024004073 HTH-like domain; Region: HTH_21; pfam13276 1303024004074 Integrase core domain; Region: rve; pfam00665 1303024004075 Integrase core domain; Region: rve_3; cl15866 1303024004076 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1303024004077 putative transposase OrfB; Reviewed; Region: PHA02517 1303024004078 HTH-like domain; Region: HTH_21; pfam13276 1303024004079 Integrase core domain; Region: rve; pfam00665 1303024004080 Integrase core domain; Region: rve_3; cl15866 1303024004081 Transposase; Region: HTH_Tnp_1; cl17663 1303024004082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024004083 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1303024004084 Transposase; Region: HTH_Tnp_1; cl17663 1303024004085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024004086 putative transposase OrfB; Reviewed; Region: PHA02517 1303024004087 HTH-like domain; Region: HTH_21; pfam13276 1303024004088 Integrase core domain; Region: rve; pfam00665 1303024004089 Integrase core domain; Region: rve_3; cl15866 1303024004090 putative transposase OrfB; Reviewed; Region: PHA02517 1303024004091 HTH-like domain; Region: HTH_21; pfam13276 1303024004092 Integrase core domain; Region: rve; pfam00665 1303024004093 Integrase core domain; Region: rve_3; cl15866 1303024004094 Transposase; Region: HTH_Tnp_1; cl17663 1303024004095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024004096 Phage capsid family; Region: Phage_capsid; pfam05065 1303024004097 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1303024004098 Phage-related protein [Function unknown]; Region: COG5412 1303024004099 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1303024004100 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1303024004101 catalytic residue [active] 1303024004102 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1303024004103 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1303024004104 active site 1303024004105 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 1303024004106 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024004107 MULE transposase domain; Region: MULE; pfam10551 1303024004108 Pleckstrin homology-like domain; Region: PH-like; cl17171 1303024004109 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1303024004110 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1303024004111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1303024004112 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1303024004113 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1303024004114 DivIVA protein; Region: DivIVA; pfam05103 1303024004115 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1303024004116 catalytic site [active] 1303024004117 putative active site [active] 1303024004118 putative substrate binding site [chemical binding]; other site 1303024004119 dimer interface [polypeptide binding]; other site 1303024004120 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1303024004121 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1303024004122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004123 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1303024004124 classical (c) SDRs; Region: SDR_c; cd05233 1303024004125 NAD(P) binding site [chemical binding]; other site 1303024004126 active site 1303024004127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024004128 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024004129 MULE transposase domain; Region: MULE; pfam10551 1303024004130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024004131 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024004132 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1303024004133 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1303024004134 Cutinase; Region: Cutinase; pfam01083 1303024004135 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1303024004136 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1303024004137 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1303024004138 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1303024004139 CysD dimerization site [polypeptide binding]; other site 1303024004140 G1 box; other site 1303024004141 putative GEF interaction site [polypeptide binding]; other site 1303024004142 GTP/Mg2+ binding site [chemical binding]; other site 1303024004143 Switch I region; other site 1303024004144 G2 box; other site 1303024004145 G3 box; other site 1303024004146 Switch II region; other site 1303024004147 G4 box; other site 1303024004148 G5 box; other site 1303024004149 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1303024004150 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1303024004151 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1303024004152 ligand-binding site [chemical binding]; other site 1303024004153 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1303024004154 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1303024004155 Active Sites [active] 1303024004156 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 1303024004157 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1303024004158 Sulfatase; Region: Sulfatase; cl17466 1303024004159 Predicted ATPase [General function prediction only]; Region: COG4637 1303024004160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024004161 Walker A/P-loop; other site 1303024004162 ATP binding site [chemical binding]; other site 1303024004163 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024004164 Cytochrome P450; Region: p450; cl12078 1303024004165 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1303024004166 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1303024004167 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1303024004168 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1303024004169 RNA binding site [nucleotide binding]; other site 1303024004170 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1303024004171 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1303024004172 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1303024004173 ligand binding site [chemical binding]; other site 1303024004174 flexible hinge region; other site 1303024004175 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1303024004176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024004177 Coenzyme A binding pocket [chemical binding]; other site 1303024004178 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1303024004179 Copper resistance protein D; Region: CopD; cl00563 1303024004180 Copper resistance protein D; Region: CopD; pfam05425 1303024004181 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1303024004182 allophanate hydrolase; Provisional; Region: PRK08186 1303024004183 Amidase; Region: Amidase; cl11426 1303024004184 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1303024004185 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1303024004186 dimer interface [polypeptide binding]; other site 1303024004187 ssDNA binding site [nucleotide binding]; other site 1303024004188 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1303024004189 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1303024004190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024004191 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024004192 ABC transporter; Region: ABC_tran_2; pfam12848 1303024004193 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024004194 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1303024004195 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1303024004196 active site 1303024004197 Pirin-related protein [General function prediction only]; Region: COG1741 1303024004198 Pirin; Region: Pirin; pfam02678 1303024004199 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1303024004200 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1303024004201 active site 1303024004202 catalytic site [active] 1303024004203 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1303024004204 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1303024004205 apolar tunnel; other site 1303024004206 heme binding site [chemical binding]; other site 1303024004207 dimerization interface [polypeptide binding]; other site 1303024004208 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1303024004209 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1303024004210 active site 1303024004211 Repair protein; Region: Repair_PSII; cl01535 1303024004212 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1303024004213 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1303024004214 Zn binding site [ion binding]; other site 1303024004215 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1303024004216 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1303024004217 Peptidase family M48; Region: Peptidase_M48; pfam01435 1303024004218 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1303024004219 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1303024004220 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1303024004221 putative DNA binding site [nucleotide binding]; other site 1303024004222 catalytic residue [active] 1303024004223 putative H2TH interface [polypeptide binding]; other site 1303024004224 putative catalytic residues [active] 1303024004225 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1303024004226 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1303024004227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024004228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024004230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004231 Predicted esterase [General function prediction only]; Region: COG0627 1303024004232 trigger factor; Provisional; Region: tig; PRK01490 1303024004233 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1303024004234 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1303024004235 Clp protease; Region: CLP_protease; pfam00574 1303024004236 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1303024004237 oligomer interface [polypeptide binding]; other site 1303024004238 active site residues [active] 1303024004239 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1303024004240 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1303024004241 oligomer interface [polypeptide binding]; other site 1303024004242 active site residues [active] 1303024004243 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1303024004244 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1303024004245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024004246 Walker A motif; other site 1303024004247 ATP binding site [chemical binding]; other site 1303024004248 Walker B motif; other site 1303024004249 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1303024004250 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024004251 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1303024004252 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1303024004253 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1303024004254 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1303024004255 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1303024004256 putative di-iron ligands [ion binding]; other site 1303024004257 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1303024004258 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1303024004259 FAD binding pocket [chemical binding]; other site 1303024004260 FAD binding motif [chemical binding]; other site 1303024004261 phosphate binding motif [ion binding]; other site 1303024004262 beta-alpha-beta structure motif; other site 1303024004263 NAD binding pocket [chemical binding]; other site 1303024004264 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024004265 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1303024004266 catalytic loop [active] 1303024004267 iron binding site [ion binding]; other site 1303024004268 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1303024004269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004270 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1303024004271 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1303024004272 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1303024004273 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1303024004274 putative molybdopterin cofactor binding site [chemical binding]; other site 1303024004275 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1303024004276 putative molybdopterin cofactor binding site; other site 1303024004277 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1303024004278 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1303024004279 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1303024004280 dimer interface [polypeptide binding]; other site 1303024004281 PYR/PP interface [polypeptide binding]; other site 1303024004282 TPP binding site [chemical binding]; other site 1303024004283 substrate binding site [chemical binding]; other site 1303024004284 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1303024004285 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1303024004286 TPP-binding site [chemical binding]; other site 1303024004287 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1303024004288 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1303024004289 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1303024004290 GTP binding site; other site 1303024004291 YibE/F-like protein; Region: YibE_F; pfam07907 1303024004292 hypothetical protein; Provisional; Region: PRK06753 1303024004293 hypothetical protein; Provisional; Region: PRK07236 1303024004294 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 1303024004295 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1303024004296 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1303024004297 active site 1303024004298 HIGH motif; other site 1303024004299 nucleotide binding site [chemical binding]; other site 1303024004300 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1303024004301 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1303024004302 active site 1303024004303 KMSKS motif; other site 1303024004304 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1303024004305 tRNA binding surface [nucleotide binding]; other site 1303024004306 anticodon binding site; other site 1303024004307 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1303024004308 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1303024004309 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1303024004310 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1303024004311 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1303024004312 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1303024004313 active site 1303024004314 multimer interface [polypeptide binding]; other site 1303024004315 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1303024004316 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1303024004317 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1303024004318 homodimer interface [polypeptide binding]; other site 1303024004319 oligonucleotide binding site [chemical binding]; other site 1303024004320 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1303024004321 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1303024004322 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1303024004323 GTP1/OBG; Region: GTP1_OBG; pfam01018 1303024004324 Obg GTPase; Region: Obg; cd01898 1303024004325 G1 box; other site 1303024004326 GTP/Mg2+ binding site [chemical binding]; other site 1303024004327 Switch I region; other site 1303024004328 G2 box; other site 1303024004329 G3 box; other site 1303024004330 Switch II region; other site 1303024004331 G4 box; other site 1303024004332 G5 box; other site 1303024004333 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1303024004334 gamma-glutamyl kinase; Provisional; Region: PRK05429 1303024004335 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1303024004336 nucleotide binding site [chemical binding]; other site 1303024004337 homotetrameric interface [polypeptide binding]; other site 1303024004338 putative phosphate binding site [ion binding]; other site 1303024004339 putative allosteric binding site; other site 1303024004340 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1303024004341 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1303024004342 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1303024004343 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1303024004344 substrate binding site [chemical binding]; other site 1303024004345 dimer interface [polypeptide binding]; other site 1303024004346 ATP binding site [chemical binding]; other site 1303024004347 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1303024004348 putative catalytic cysteine [active] 1303024004349 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1303024004350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024004351 Walker A motif; other site 1303024004352 ATP binding site [chemical binding]; other site 1303024004353 Walker B motif; other site 1303024004354 arginine finger; other site 1303024004355 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1303024004356 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1303024004357 metal ion-dependent adhesion site (MIDAS); other site 1303024004358 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1303024004359 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1303024004360 active site 1303024004361 (T/H)XGH motif; other site 1303024004362 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1303024004363 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024004364 catalytic core [active] 1303024004365 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1303024004366 active site 1303024004367 catalytic triad [active] 1303024004368 oxyanion hole [active] 1303024004369 EDD domain protein, DegV family; Region: DegV; TIGR00762 1303024004370 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1303024004371 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1303024004372 Helix-hairpin-helix motif; Region: HHH; pfam00633 1303024004373 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1303024004374 Competence protein; Region: Competence; pfam03772 1303024004375 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1303024004376 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1303024004377 hypothetical protein; Reviewed; Region: PRK07914 1303024004378 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1303024004379 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1303024004380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1303024004381 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1303024004382 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1303024004383 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1303024004384 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1303024004385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004386 PemK-like protein; Region: PemK; pfam02452 1303024004387 GTP-binding protein LepA; Provisional; Region: PRK05433 1303024004388 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1303024004389 G1 box; other site 1303024004390 putative GEF interaction site [polypeptide binding]; other site 1303024004391 GTP/Mg2+ binding site [chemical binding]; other site 1303024004392 Switch I region; other site 1303024004393 G2 box; other site 1303024004394 G3 box; other site 1303024004395 Switch II region; other site 1303024004396 G4 box; other site 1303024004397 G5 box; other site 1303024004398 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1303024004399 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1303024004400 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1303024004401 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1303024004402 Nitronate monooxygenase; Region: NMO; pfam03060 1303024004403 FMN binding site [chemical binding]; other site 1303024004404 substrate binding site [chemical binding]; other site 1303024004405 putative catalytic residue [active] 1303024004406 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1303024004407 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1303024004408 hypothetical protein; Provisional; Region: PRK06185 1303024004409 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024004410 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1303024004411 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1303024004412 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1303024004413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024004414 dimer interface [polypeptide binding]; other site 1303024004415 conserved gate region; other site 1303024004416 putative PBP binding loops; other site 1303024004417 ABC-ATPase subunit interface; other site 1303024004418 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1303024004419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024004420 dimer interface [polypeptide binding]; other site 1303024004421 conserved gate region; other site 1303024004422 putative PBP binding loops; other site 1303024004423 ABC-ATPase subunit interface; other site 1303024004424 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1303024004425 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1303024004426 Walker A/P-loop; other site 1303024004427 ATP binding site [chemical binding]; other site 1303024004428 Q-loop/lid; other site 1303024004429 ABC transporter signature motif; other site 1303024004430 Walker B; other site 1303024004431 D-loop; other site 1303024004432 H-loop/switch region; other site 1303024004433 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1303024004434 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1303024004435 putative active site [active] 1303024004436 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1303024004437 putative active site [active] 1303024004438 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1303024004439 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1303024004440 CysD dimerization site [polypeptide binding]; other site 1303024004441 G1 box; other site 1303024004442 putative GEF interaction site [polypeptide binding]; other site 1303024004443 GTP/Mg2+ binding site [chemical binding]; other site 1303024004444 Switch I region; other site 1303024004445 G2 box; other site 1303024004446 G3 box; other site 1303024004447 Switch II region; other site 1303024004448 G4 box; other site 1303024004449 G5 box; other site 1303024004450 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1303024004451 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1303024004452 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1303024004453 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1303024004454 Active Sites [active] 1303024004455 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1303024004456 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1303024004457 Active Sites [active] 1303024004458 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1303024004459 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1303024004460 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1303024004461 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1303024004462 HemN C-terminal domain; Region: HemN_C; pfam06969 1303024004463 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1303024004464 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1303024004465 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1303024004466 chaperone protein DnaJ; Provisional; Region: PRK14278 1303024004467 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1303024004468 HSP70 interaction site [polypeptide binding]; other site 1303024004469 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1303024004470 Zn binding sites [ion binding]; other site 1303024004471 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1303024004472 dimer interface [polypeptide binding]; other site 1303024004473 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1303024004474 K homology RNA-binding domain; Region: KH; smart00322 1303024004475 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1303024004476 PhoH-like protein; Region: PhoH; pfam02562 1303024004477 metal-binding heat shock protein; Provisional; Region: PRK00016 1303024004478 Domain of unknown function DUF21; Region: DUF21; pfam01595 1303024004479 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1303024004480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1303024004481 Transporter associated domain; Region: CorC_HlyC; smart01091 1303024004482 enolase; Provisional; Region: eno; PRK00077 1303024004483 GTPase Era; Reviewed; Region: era; PRK00089 1303024004484 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1303024004485 G1 box; other site 1303024004486 GTP/Mg2+ binding site [chemical binding]; other site 1303024004487 Switch I region; other site 1303024004488 G2 box; other site 1303024004489 Switch II region; other site 1303024004490 G3 box; other site 1303024004491 G4 box; other site 1303024004492 G5 box; other site 1303024004493 KH domain; Region: KH_2; pfam07650 1303024004494 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1303024004495 amidase; Provisional; Region: PRK06061 1303024004496 Amidase; Region: Amidase; pfam01425 1303024004497 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1303024004498 Recombination protein O N terminal; Region: RecO_N; pfam11967 1303024004499 Recombination protein O C terminal; Region: RecO_C; pfam02565 1303024004500 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1303024004501 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1303024004502 catalytic residue [active] 1303024004503 putative FPP diphosphate binding site; other site 1303024004504 putative FPP binding hydrophobic cleft; other site 1303024004505 dimer interface [polypeptide binding]; other site 1303024004506 putative IPP diphosphate binding site; other site 1303024004507 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1303024004508 metal binding site 2 [ion binding]; metal-binding site 1303024004509 putative DNA binding helix; other site 1303024004510 metal binding site 1 [ion binding]; metal-binding site 1303024004511 dimer interface [polypeptide binding]; other site 1303024004512 structural Zn2+ binding site [ion binding]; other site 1303024004513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024004514 dimerization interface [polypeptide binding]; other site 1303024004515 putative DNA binding site [nucleotide binding]; other site 1303024004516 putative Zn2+ binding site [ion binding]; other site 1303024004517 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1303024004518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024004519 NAD(P) binding site [chemical binding]; other site 1303024004520 active site 1303024004521 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1303024004522 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1303024004523 putative di-iron ligands [ion binding]; other site 1303024004524 2,4-diaminobutyrate 4-transaminases; Region: dat; TIGR00709 1303024004525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024004526 inhibitor-cofactor binding pocket; inhibition site 1303024004527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024004528 catalytic residue [active] 1303024004529 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1303024004530 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024004531 catalytic residue [active] 1303024004532 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1303024004533 hydrophobic ligand binding site; other site 1303024004534 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1303024004535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024004536 Walker A/P-loop; other site 1303024004537 ATP binding site [chemical binding]; other site 1303024004538 Q-loop/lid; other site 1303024004539 ABC transporter signature motif; other site 1303024004540 Walker B; other site 1303024004541 D-loop; other site 1303024004542 H-loop/switch region; other site 1303024004543 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1303024004544 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1303024004545 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1303024004546 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1303024004547 acyl-activating enzyme (AAE) consensus motif; other site 1303024004548 active site 1303024004549 Permease; Region: Permease; pfam02405 1303024004550 Permease; Region: Permease; pfam02405 1303024004551 mce related protein; Region: MCE; pfam02470 1303024004552 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1303024004553 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1303024004554 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024004555 mce related protein; Region: MCE; pfam02470 1303024004556 mce related protein; Region: MCE; pfam02470 1303024004557 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024004558 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024004559 mce related protein; Region: MCE; pfam02470 1303024004560 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024004561 mce related protein; Region: MCE; pfam02470 1303024004562 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024004563 mce related protein; Region: MCE; pfam02470 1303024004564 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024004565 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024004566 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1303024004567 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1303024004568 motif 1; other site 1303024004569 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1303024004570 active site 1303024004571 motif 2; other site 1303024004572 motif 3; other site 1303024004573 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1303024004574 anticodon binding site; other site 1303024004575 hypothetical protein; Provisional; Region: PRK06062 1303024004576 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024004577 inhibitor-cofactor binding pocket; inhibition site 1303024004578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024004579 catalytic residue [active] 1303024004580 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1303024004581 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1303024004582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024004583 catalytic residue [active] 1303024004584 transcriptional regulator NanR; Provisional; Region: PRK03837 1303024004585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024004586 DNA-binding site [nucleotide binding]; DNA binding site 1303024004587 FCD domain; Region: FCD; pfam07729 1303024004588 Repair protein; Region: Repair_PSII; pfam04536 1303024004589 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1303024004590 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1303024004591 Zn2+ binding site [ion binding]; other site 1303024004592 Mg2+ binding site [ion binding]; other site 1303024004593 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1303024004594 DNA primase; Validated; Region: dnaG; PRK05667 1303024004595 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1303024004596 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1303024004597 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1303024004598 active site 1303024004599 metal binding site [ion binding]; metal-binding site 1303024004600 interdomain interaction site; other site 1303024004601 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1303024004602 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1303024004603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1303024004604 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1303024004605 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1303024004606 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1303024004607 Walker A/P-loop; other site 1303024004608 ATP binding site [chemical binding]; other site 1303024004609 Q-loop/lid; other site 1303024004610 ABC transporter signature motif; other site 1303024004611 Walker B; other site 1303024004612 D-loop; other site 1303024004613 H-loop/switch region; other site 1303024004614 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1303024004615 Walker A/P-loop; other site 1303024004616 ATP binding site [chemical binding]; other site 1303024004617 Q-loop/lid; other site 1303024004618 ABC transporter signature motif; other site 1303024004619 Walker B; other site 1303024004620 D-loop; other site 1303024004621 H-loop/switch region; other site 1303024004622 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1303024004623 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1303024004624 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1303024004625 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1303024004626 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1303024004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024004628 dimer interface [polypeptide binding]; other site 1303024004629 conserved gate region; other site 1303024004630 putative PBP binding loops; other site 1303024004631 ABC-ATPase subunit interface; other site 1303024004632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1303024004633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024004634 ABC-ATPase subunit interface; other site 1303024004635 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1303024004636 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1303024004637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024004638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024004639 active site 1303024004640 phosphorylation site [posttranslational modification] 1303024004641 intermolecular recognition site; other site 1303024004642 dimerization interface [polypeptide binding]; other site 1303024004643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024004644 DNA binding site [nucleotide binding] 1303024004645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024004646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1303024004647 dimerization interface [polypeptide binding]; other site 1303024004648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024004649 dimer interface [polypeptide binding]; other site 1303024004650 phosphorylation site [posttranslational modification] 1303024004651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024004652 ATP binding site [chemical binding]; other site 1303024004653 Mg2+ binding site [ion binding]; other site 1303024004654 G-X-G motif; other site 1303024004655 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1303024004656 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1303024004657 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 1303024004658 active site 1303024004659 Zn binding site [ion binding]; other site 1303024004660 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1303024004661 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1303024004662 metal binding site [ion binding]; metal-binding site 1303024004663 active site 1303024004664 I-site; other site 1303024004665 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1303024004666 active site 1303024004667 catalytic residues [active] 1303024004668 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1303024004669 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1303024004670 putative heme binding pocket [chemical binding]; other site 1303024004671 putative transposase OrfB; Reviewed; Region: PHA02517 1303024004672 HTH-like domain; Region: HTH_21; pfam13276 1303024004673 Integrase core domain; Region: rve; pfam00665 1303024004674 Integrase core domain; Region: rve_3; pfam13683 1303024004675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024004676 Transposase; Region: HTH_Tnp_1; cl17663 1303024004677 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1303024004678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024004679 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1303024004680 Walker A/P-loop; other site 1303024004681 ATP binding site [chemical binding]; other site 1303024004682 Q-loop/lid; other site 1303024004683 ABC transporter signature motif; other site 1303024004684 Walker B; other site 1303024004685 D-loop; other site 1303024004686 H-loop/switch region; other site 1303024004687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024004688 Walker A/P-loop; other site 1303024004689 ATP binding site [chemical binding]; other site 1303024004690 Q-loop/lid; other site 1303024004691 ABC transporter signature motif; other site 1303024004692 Walker B; other site 1303024004693 D-loop; other site 1303024004694 H-loop/switch region; other site 1303024004695 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1303024004696 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1303024004697 active site 1303024004698 Zn binding site [ion binding]; other site 1303024004699 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1303024004700 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1303024004701 active site 1303024004702 Zn binding site [ion binding]; other site 1303024004703 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024004704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024004705 active site 1303024004706 Isochorismatase family; Region: Isochorismatase; pfam00857 1303024004707 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1303024004708 catalytic triad [active] 1303024004709 conserved cis-peptide bond; other site 1303024004710 TIGR03086 family protein; Region: TIGR03086 1303024004711 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024004712 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1303024004713 homodimer interface [polypeptide binding]; other site 1303024004714 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1303024004715 active site pocket [active] 1303024004716 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1303024004717 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1303024004718 NAD(P) binding site [chemical binding]; other site 1303024004719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024004720 putative DNA binding site [nucleotide binding]; other site 1303024004721 putative Zn2+ binding site [ion binding]; other site 1303024004722 MarR family; Region: MarR_2; cl17246 1303024004723 Predicted transcriptional regulators [Transcription]; Region: COG1510 1303024004724 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1303024004725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024004726 Walker A/P-loop; other site 1303024004727 ATP binding site [chemical binding]; other site 1303024004728 Q-loop/lid; other site 1303024004729 ABC transporter signature motif; other site 1303024004730 Walker B; other site 1303024004731 D-loop; other site 1303024004732 H-loop/switch region; other site 1303024004733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024004734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004735 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1303024004736 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024004737 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024004738 active site 1303024004739 lipid-transfer protein; Provisional; Region: PRK08256 1303024004740 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024004741 active site 1303024004742 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1303024004743 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1303024004744 acyl-activating enzyme (AAE) consensus motif; other site 1303024004745 putative AMP binding site [chemical binding]; other site 1303024004746 putative active site [active] 1303024004747 putative CoA binding site [chemical binding]; other site 1303024004748 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1303024004749 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1303024004750 metal binding site [ion binding]; metal-binding site 1303024004751 active site 1303024004752 I-site; other site 1303024004753 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1303024004754 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1303024004755 active site 1303024004756 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1303024004757 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1303024004758 NAD binding site [chemical binding]; other site 1303024004759 catalytic Zn binding site [ion binding]; other site 1303024004760 substrate binding site [chemical binding]; other site 1303024004761 structural Zn binding site [ion binding]; other site 1303024004762 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024004763 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024004764 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1303024004765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024004766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004767 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1303024004768 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1303024004769 putative NAD(P) binding site [chemical binding]; other site 1303024004770 haloalkane dehalogenase; Provisional; Region: PRK03592 1303024004771 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1303024004772 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1303024004773 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1303024004774 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1303024004775 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1303024004776 dimer interface [polypeptide binding]; other site 1303024004777 active site 1303024004778 acyl carrier protein; Provisional; Region: acpP; PRK00982 1303024004779 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1303024004780 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1303024004781 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1303024004782 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024004783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024004784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024004785 DoxX; Region: DoxX; cl17842 1303024004786 Electron transfer DM13; Region: DM13; cl02735 1303024004787 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1303024004788 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1303024004789 dimer interface [polypeptide binding]; other site 1303024004790 TPP-binding site [chemical binding]; other site 1303024004791 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1303024004792 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1303024004793 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1303024004794 dimer interface [polypeptide binding]; other site 1303024004795 catalytic triad [active] 1303024004796 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1303024004797 active site 1303024004798 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1303024004799 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1303024004800 MspA; Region: MspA; pfam09203 1303024004801 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1303024004802 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1303024004803 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1303024004804 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1303024004805 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1303024004806 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1303024004807 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1303024004808 active site 1303024004809 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1303024004810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024004811 motif II; other site 1303024004812 hypothetical protein; Provisional; Region: PRK07908 1303024004813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024004814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024004815 homodimer interface [polypeptide binding]; other site 1303024004816 catalytic residue [active] 1303024004817 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1303024004818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1303024004819 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1303024004820 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1303024004821 Putative zinc ribbon domain; Region: DUF164; pfam02591 1303024004822 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1303024004823 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1303024004824 RNA/DNA hybrid binding site [nucleotide binding]; other site 1303024004825 active site 1303024004826 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024004827 catalytic core [active] 1303024004828 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1303024004829 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1303024004830 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1303024004831 active site 1303024004832 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1303024004833 Protein of unknown function DUF58; Region: DUF58; pfam01882 1303024004834 MoxR-like ATPases [General function prediction only]; Region: COG0714 1303024004835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024004836 Walker A motif; other site 1303024004837 ATP binding site [chemical binding]; other site 1303024004838 Walker B motif; other site 1303024004839 arginine finger; other site 1303024004840 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1303024004841 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1303024004842 active site 1303024004843 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1303024004844 RNB domain; Region: RNB; pfam00773 1303024004845 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1303024004846 putative active site; other site 1303024004847 putative metal binding residues [ion binding]; other site 1303024004848 signature motif; other site 1303024004849 putative triphosphate binding site [ion binding]; other site 1303024004850 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1303024004851 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1303024004852 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1303024004853 acyl-activating enzyme (AAE) consensus motif; other site 1303024004854 active site 1303024004855 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1303024004856 oligomerization interface [polypeptide binding]; other site 1303024004857 active site 1303024004858 metal binding site [ion binding]; metal-binding site 1303024004859 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1303024004860 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1303024004861 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1303024004862 TAP-like protein; Region: Abhydrolase_4; pfam08386 1303024004863 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1303024004864 TAP-like protein; Region: Abhydrolase_4; pfam08386 1303024004865 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1303024004866 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1303024004867 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1303024004868 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1303024004869 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1303024004870 metal binding triad; other site 1303024004871 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1303024004872 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1303024004873 metal binding triad; other site 1303024004874 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1303024004875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024004876 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1303024004877 active site 1303024004878 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024004879 MarR family; Region: MarR_2; pfam12802 1303024004880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024004881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024004882 active site 1303024004883 phosphorylation site [posttranslational modification] 1303024004884 intermolecular recognition site; other site 1303024004885 dimerization interface [polypeptide binding]; other site 1303024004886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024004887 DNA binding site [nucleotide binding] 1303024004888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024004889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024004890 phosphorylation site [posttranslational modification] 1303024004891 dimer interface [polypeptide binding]; other site 1303024004892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024004893 Mg2+ binding site [ion binding]; other site 1303024004894 G-X-G motif; other site 1303024004895 SnoaL-like domain; Region: SnoaL_2; pfam12680 1303024004896 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1303024004897 putative catalytic site [active] 1303024004898 putative phosphate binding site [ion binding]; other site 1303024004899 putative metal binding site [ion binding]; other site 1303024004900 Predicted membrane protein [Function unknown]; Region: COG2259 1303024004901 Predicted membrane protein [Function unknown]; Region: COG2259 1303024004902 chaperone protein HchA; Provisional; Region: PRK04155 1303024004903 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1303024004904 conserved cys residue [active] 1303024004905 glutamine synthetase, type I; Region: GlnA; TIGR00653 1303024004906 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1303024004907 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1303024004908 RDD family; Region: RDD; pfam06271 1303024004909 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1303024004910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024004911 putative substrate translocation pore; other site 1303024004912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1303024004913 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1303024004914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024004915 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024004916 Cytochrome P450; Region: p450; cl12078 1303024004917 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1303024004918 lipoyl synthase; Provisional; Region: PRK05481 1303024004919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024004920 FeS/SAM binding site; other site 1303024004921 lipoate-protein ligase B; Provisional; Region: PRK14345 1303024004922 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1303024004923 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1303024004924 putative NAD(P) binding site [chemical binding]; other site 1303024004925 putative active site [active] 1303024004926 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1303024004927 E3 interaction surface; other site 1303024004928 lipoyl attachment site [posttranslational modification]; other site 1303024004929 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1303024004930 E3 interaction surface; other site 1303024004931 lipoyl attachment site [posttranslational modification]; other site 1303024004932 e3 binding domain; Region: E3_binding; pfam02817 1303024004933 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1303024004934 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1303024004935 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1303024004936 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1303024004937 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1303024004938 interface (dimer of trimers) [polypeptide binding]; other site 1303024004939 Substrate-binding/catalytic site; other site 1303024004940 Zn-binding sites [ion binding]; other site 1303024004941 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1303024004942 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1303024004943 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1303024004944 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1303024004945 homodimer interface [polypeptide binding]; other site 1303024004946 substrate-cofactor binding pocket; other site 1303024004947 catalytic residue [active] 1303024004948 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1303024004949 active site 1303024004950 metal binding site [ion binding]; metal-binding site 1303024004951 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1303024004952 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1303024004953 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1303024004954 putative dimer interface [polypeptide binding]; other site 1303024004955 active site pocket [active] 1303024004956 putative cataytic base [active] 1303024004957 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1303024004958 homotrimer interface [polypeptide binding]; other site 1303024004959 Walker A motif; other site 1303024004960 GTP binding site [chemical binding]; other site 1303024004961 Walker B motif; other site 1303024004962 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1303024004963 Glycerate kinase family; Region: Gly_kinase; cl00841 1303024004964 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1303024004965 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1303024004966 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1303024004967 substrate binding site [chemical binding]; other site 1303024004968 ATP binding site [chemical binding]; other site 1303024004969 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1303024004970 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1303024004971 active site 1303024004972 dimer interface [polypeptide binding]; other site 1303024004973 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1303024004974 Ligand Binding Site [chemical binding]; other site 1303024004975 Molecular Tunnel; other site 1303024004976 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1303024004977 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1303024004978 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1303024004979 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1303024004980 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1303024004981 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1303024004982 heme bH binding site [chemical binding]; other site 1303024004983 intrachain domain interface; other site 1303024004984 heme bL binding site [chemical binding]; other site 1303024004985 interchain domain interface [polypeptide binding]; other site 1303024004986 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1303024004987 Qo binding site; other site 1303024004988 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1303024004989 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1303024004990 iron-sulfur cluster [ion binding]; other site 1303024004991 [2Fe-2S] cluster binding site [ion binding]; other site 1303024004992 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1303024004993 Cytochrome c; Region: Cytochrom_C; pfam00034 1303024004994 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1303024004995 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1303024004996 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1303024004997 Subunit I/III interface [polypeptide binding]; other site 1303024004998 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1303024004999 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1303024005000 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1303024005001 hypothetical protein; Validated; Region: PRK07883 1303024005002 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1303024005003 active site 1303024005004 catalytic site [active] 1303024005005 substrate binding site [chemical binding]; other site 1303024005006 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1303024005007 GIY-YIG motif/motif A; other site 1303024005008 active site 1303024005009 catalytic site [active] 1303024005010 putative DNA binding site [nucleotide binding]; other site 1303024005011 metal binding site [ion binding]; metal-binding site 1303024005012 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024005013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024005014 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1303024005015 NlpC/P60 family; Region: NLPC_P60; pfam00877 1303024005016 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1303024005017 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1303024005018 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024005019 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024005020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024005021 S-adenosylmethionine binding site [chemical binding]; other site 1303024005022 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1303024005023 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1303024005024 acyl-activating enzyme (AAE) consensus motif; other site 1303024005025 putative AMP binding site [chemical binding]; other site 1303024005026 putative active site [active] 1303024005027 putative CoA binding site [chemical binding]; other site 1303024005028 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1303024005029 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024005030 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024005031 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1303024005032 putative hydrophobic ligand binding site [chemical binding]; other site 1303024005033 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1303024005034 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1303024005035 P loop; other site 1303024005036 Nucleotide binding site [chemical binding]; other site 1303024005037 DTAP/Switch II; other site 1303024005038 Switch I; other site 1303024005039 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1303024005040 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1303024005041 putative acyl-acceptor binding pocket; other site 1303024005042 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1303024005043 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1303024005044 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1303024005045 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1303024005046 active site 1303024005047 ATP binding site [chemical binding]; other site 1303024005048 substrate binding site [chemical binding]; other site 1303024005049 activation loop (A-loop); other site 1303024005050 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1303024005051 putative hydrophobic ligand binding site [chemical binding]; other site 1303024005052 Helix-turn-helix domain; Region: HTH_17; pfam12728 1303024005053 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1303024005054 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1303024005055 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1303024005056 substrate binding pocket [chemical binding]; other site 1303024005057 chain length determination region; other site 1303024005058 substrate-Mg2+ binding site; other site 1303024005059 catalytic residues [active] 1303024005060 aspartate-rich region 1; other site 1303024005061 active site lid residues [active] 1303024005062 aspartate-rich region 2; other site 1303024005063 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1303024005064 FAD binding site [chemical binding]; other site 1303024005065 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1303024005066 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1303024005067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1303024005068 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1303024005069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1303024005070 MraZ protein; Region: MraZ; pfam02381 1303024005071 MraZ protein; Region: MraZ; pfam02381 1303024005072 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1303024005073 MraW methylase family; Region: Methyltransf_5; cl17771 1303024005074 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1303024005075 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1303024005076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1303024005077 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1303024005078 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1303024005079 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1303024005080 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1303024005081 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1303024005082 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1303024005083 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1303024005084 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1303024005085 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1303024005086 Mg++ binding site [ion binding]; other site 1303024005087 putative catalytic motif [active] 1303024005088 putative substrate binding site [chemical binding]; other site 1303024005089 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1303024005090 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1303024005091 cell division protein FtsW; Region: ftsW; TIGR02614 1303024005092 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1303024005093 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1303024005094 active site 1303024005095 homodimer interface [polypeptide binding]; other site 1303024005096 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1303024005097 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1303024005098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1303024005099 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1303024005100 Cell division protein FtsQ; Region: FtsQ; pfam03799 1303024005101 cell division protein FtsZ; Validated; Region: PRK09330 1303024005102 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1303024005103 nucleotide binding site [chemical binding]; other site 1303024005104 SulA interaction site; other site 1303024005105 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1303024005106 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1303024005107 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1303024005108 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1303024005109 catalytic residue [active] 1303024005110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1303024005111 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1303024005112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024005113 putative DNA binding site [nucleotide binding]; other site 1303024005114 dimerization interface [polypeptide binding]; other site 1303024005115 putative Zn2+ binding site [ion binding]; other site 1303024005116 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1303024005117 putative hydrophobic ligand binding site [chemical binding]; other site 1303024005118 DivIVA domain; Region: DivI1A_domain; TIGR03544 1303024005119 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1303024005120 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1303024005121 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1303024005122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024005123 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1303024005124 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1303024005125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024005126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024005127 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1303024005128 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1303024005129 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1303024005130 dimer interface [polypeptide binding]; other site 1303024005131 active site 1303024005132 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1303024005133 active site 1303024005134 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1303024005135 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1303024005136 dimer interface [polypeptide binding]; other site 1303024005137 active site 1303024005138 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1303024005139 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1303024005140 active site 1303024005141 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1303024005142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024005143 NAD(P) binding site [chemical binding]; other site 1303024005144 active site 1303024005145 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1303024005146 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1303024005147 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1303024005148 acyltransferase PapA5; Provisional; Region: PRK09294 1303024005149 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024005150 Transport protein; Region: actII; TIGR00833 1303024005151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024005152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024005153 putative substrate translocation pore; other site 1303024005154 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024005155 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024005156 substrate binding pocket [chemical binding]; other site 1303024005157 hypothetical protein; Provisional; Region: PRK07906 1303024005158 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1303024005159 putative metal binding site [ion binding]; other site 1303024005160 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1303024005161 substrate binding site [chemical binding]; other site 1303024005162 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1303024005163 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1303024005164 quinone interaction residues [chemical binding]; other site 1303024005165 active site 1303024005166 catalytic residues [active] 1303024005167 FMN binding site [chemical binding]; other site 1303024005168 substrate binding site [chemical binding]; other site 1303024005169 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1303024005170 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024005171 catalytic core [active] 1303024005172 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1303024005173 conserved hypothetical protein; Region: TIGR03843 1303024005174 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1303024005175 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024005176 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1303024005177 active site 1303024005178 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1303024005179 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1303024005180 active site 1303024005181 HIGH motif; other site 1303024005182 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1303024005183 active site 1303024005184 KMSKS motif; other site 1303024005185 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1303024005186 putative tRNA binding surface [nucleotide binding]; other site 1303024005187 short chain dehydrogenase; Provisional; Region: PRK05872 1303024005188 classical (c) SDRs; Region: SDR_c; cd05233 1303024005189 NAD(P) binding site [chemical binding]; other site 1303024005190 active site 1303024005191 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1303024005192 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1303024005193 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1303024005194 NADP binding site [chemical binding]; other site 1303024005195 active site 1303024005196 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1303024005197 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1303024005198 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1303024005199 active site 1303024005200 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1303024005201 Condensation domain; Region: Condensation; pfam00668 1303024005202 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024005203 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024005204 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024005205 acyl-activating enzyme (AAE) consensus motif; other site 1303024005206 AMP binding site [chemical binding]; other site 1303024005207 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024005208 Condensation domain; Region: Condensation; pfam00668 1303024005209 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024005210 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024005211 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024005212 Condensation domain; Region: Condensation; pfam00668 1303024005213 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024005214 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024005215 acyl-activating enzyme (AAE) consensus motif; other site 1303024005216 AMP binding site [chemical binding]; other site 1303024005217 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024005218 Condensation domain; Region: Condensation; pfam00668 1303024005219 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1303024005220 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1303024005221 Condensation domain; Region: Condensation; pfam00668 1303024005222 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024005223 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1303024005224 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1303024005225 acyl-activating enzyme (AAE) consensus motif; other site 1303024005226 AMP binding site [chemical binding]; other site 1303024005227 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024005228 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1303024005229 putative FMN binding site [chemical binding]; other site 1303024005230 NADPH bind site [chemical binding]; other site 1303024005231 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1303024005232 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1303024005233 phosphate binding site [ion binding]; other site 1303024005234 Predicted membrane protein [Function unknown]; Region: COG2860 1303024005235 UPF0126 domain; Region: UPF0126; pfam03458 1303024005236 UPF0126 domain; Region: UPF0126; pfam03458 1303024005237 PAC2 family; Region: PAC2; pfam09754 1303024005238 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1303024005239 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1303024005240 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1303024005241 substrate binding pocket [chemical binding]; other site 1303024005242 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1303024005243 B12 binding site [chemical binding]; other site 1303024005244 cobalt ligand [ion binding]; other site 1303024005245 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1303024005246 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1303024005247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024005248 motif II; other site 1303024005249 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1303024005250 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1303024005251 homodimer interface [polypeptide binding]; other site 1303024005252 putative metal binding site [ion binding]; other site 1303024005253 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1303024005254 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1303024005255 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1303024005256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1303024005257 active site 1303024005258 phosphorylation site [posttranslational modification] 1303024005259 intermolecular recognition site; other site 1303024005260 dimerization interface [polypeptide binding]; other site 1303024005261 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1303024005262 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1303024005263 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1303024005264 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1303024005265 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1303024005266 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024005267 MULE transposase domain; Region: MULE; pfam10551 1303024005268 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1303024005269 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1303024005270 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1303024005271 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1303024005272 putative dimer interface [polypeptide binding]; other site 1303024005273 [2Fe-2S] cluster binding site [ion binding]; other site 1303024005274 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1303024005275 SLBB domain; Region: SLBB; pfam10531 1303024005276 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1303024005277 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1303024005278 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024005279 catalytic loop [active] 1303024005280 iron binding site [ion binding]; other site 1303024005281 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1303024005282 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1303024005283 molybdopterin cofactor binding site; other site 1303024005284 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1303024005285 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1303024005286 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1303024005287 4Fe-4S binding domain; Region: Fer4; pfam00037 1303024005288 4Fe-4S binding domain; Region: Fer4; pfam00037 1303024005289 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1303024005290 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1303024005291 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1303024005292 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1303024005293 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1303024005294 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1303024005295 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1303024005296 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1303024005297 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1303024005298 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1303024005299 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1303024005300 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1303024005301 putative di-iron ligands [ion binding]; other site 1303024005302 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1303024005303 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1303024005304 molybdopterin cofactor binding site; other site 1303024005305 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1303024005306 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 1303024005307 putative molybdopterin cofactor binding site; other site 1303024005308 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1303024005309 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1303024005310 FAD binding pocket [chemical binding]; other site 1303024005311 conserved FAD binding motif [chemical binding]; other site 1303024005312 phosphate binding motif [ion binding]; other site 1303024005313 beta-alpha-beta structure motif; other site 1303024005314 NAD binding pocket [chemical binding]; other site 1303024005315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024005316 catalytic loop [active] 1303024005317 iron binding site [ion binding]; other site 1303024005318 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1303024005319 SnoaL-like domain; Region: SnoaL_2; pfam12680 1303024005320 Cytochrome P450; Region: p450; cl12078 1303024005321 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024005322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024005323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024005324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1303024005325 MOSC domain; Region: MOSC; pfam03473 1303024005326 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1303024005327 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024005328 active site 2 [active] 1303024005329 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1303024005330 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1303024005331 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024005332 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1303024005333 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1303024005334 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1303024005335 homodimer interface [polypeptide binding]; other site 1303024005336 putative substrate binding pocket [chemical binding]; other site 1303024005337 diiron center [ion binding]; other site 1303024005338 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1303024005339 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1303024005340 ATP binding site [chemical binding]; other site 1303024005341 Mg++ binding site [ion binding]; other site 1303024005342 motif III; other site 1303024005343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024005344 nucleotide binding region [chemical binding]; other site 1303024005345 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1303024005346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024005347 S-adenosylmethionine binding site [chemical binding]; other site 1303024005348 proteasome ATPase; Region: pup_AAA; TIGR03689 1303024005349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024005350 Walker A motif; other site 1303024005351 ATP binding site [chemical binding]; other site 1303024005352 Walker B motif; other site 1303024005353 arginine finger; other site 1303024005354 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1303024005355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024005356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024005357 DNA binding residues [nucleotide binding] 1303024005358 Putative zinc-finger; Region: zf-HC2; pfam13490 1303024005359 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1303024005360 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1303024005361 PYR/PP interface [polypeptide binding]; other site 1303024005362 dimer interface [polypeptide binding]; other site 1303024005363 TPP binding site [chemical binding]; other site 1303024005364 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1303024005365 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1303024005366 TPP-binding site [chemical binding]; other site 1303024005367 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1303024005368 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1303024005369 active site 1303024005370 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 1303024005371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024005372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024005373 homodimer interface [polypeptide binding]; other site 1303024005374 catalytic residue [active] 1303024005375 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024005376 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1303024005377 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1303024005378 Pup-like protein; Region: Pup; cl05289 1303024005379 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1303024005380 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1303024005381 active site 1303024005382 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1303024005383 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1303024005384 active site 1303024005385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1303024005386 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1303024005387 ABC-ATPase subunit interface; other site 1303024005388 putative PBP binding loops; other site 1303024005389 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1303024005390 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1303024005391 substrate binding pocket [chemical binding]; other site 1303024005392 membrane-bound complex binding site; other site 1303024005393 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1303024005394 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1303024005395 Walker A/P-loop; other site 1303024005396 ATP binding site [chemical binding]; other site 1303024005397 Q-loop/lid; other site 1303024005398 ABC transporter signature motif; other site 1303024005399 Walker B; other site 1303024005400 D-loop; other site 1303024005401 H-loop/switch region; other site 1303024005402 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024005403 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024005404 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1303024005405 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1303024005406 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1303024005407 Amidase; Region: Amidase; cl11426 1303024005408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024005409 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1303024005410 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1303024005411 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1303024005412 Predicted transcriptional regulator [Transcription]; Region: COG2378 1303024005413 WYL domain; Region: WYL; pfam13280 1303024005414 Predicted transcriptional regulator [Transcription]; Region: COG2378 1303024005415 WYL domain; Region: WYL; pfam13280 1303024005416 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1303024005417 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 1303024005418 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1303024005419 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1303024005420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024005421 ATP binding site [chemical binding]; other site 1303024005422 putative Mg++ binding site [ion binding]; other site 1303024005423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024005424 nucleotide binding region [chemical binding]; other site 1303024005425 ATP-binding site [chemical binding]; other site 1303024005426 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1303024005427 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1303024005428 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1303024005429 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1303024005430 active site 1303024005431 metal binding site 1 [ion binding]; metal-binding site 1303024005432 putative 5' ssDNA interaction site; other site 1303024005433 metal binding site 3; metal-binding site 1303024005434 metal binding site 2 [ion binding]; metal-binding site 1303024005435 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1303024005436 putative DNA binding site [nucleotide binding]; other site 1303024005437 putative metal binding site [ion binding]; other site 1303024005438 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1303024005439 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1303024005440 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1303024005441 active site 1303024005442 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1303024005443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024005444 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1303024005445 NAD(P) binding site [chemical binding]; other site 1303024005446 active site 1303024005447 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1303024005448 active site 1303024005449 putative homodimer interface [polypeptide binding]; other site 1303024005450 SAM binding site [chemical binding]; other site 1303024005451 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1303024005452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024005453 S-adenosylmethionine binding site [chemical binding]; other site 1303024005454 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1303024005455 active site 1303024005456 SAM binding site [chemical binding]; other site 1303024005457 homodimer interface [polypeptide binding]; other site 1303024005458 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1303024005459 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1303024005460 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1303024005461 active site 1303024005462 SAM binding site [chemical binding]; other site 1303024005463 homodimer interface [polypeptide binding]; other site 1303024005464 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1303024005465 active site 1303024005466 SAM binding site [chemical binding]; other site 1303024005467 homodimer interface [polypeptide binding]; other site 1303024005468 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1303024005469 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1303024005470 precorrin-3B synthase; Region: CobG; TIGR02435 1303024005471 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1303024005472 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1303024005473 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1303024005474 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024005475 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1303024005476 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1303024005477 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1303024005478 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1303024005479 active site 1303024005480 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1303024005481 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1303024005482 putative active site [active] 1303024005483 catalytic triad [active] 1303024005484 putative dimer interface [polypeptide binding]; other site 1303024005485 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1303024005486 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1303024005487 Ligand binding site; other site 1303024005488 Putative Catalytic site; other site 1303024005489 DXD motif; other site 1303024005490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024005491 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1303024005492 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024005493 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1303024005494 Transport protein; Region: actII; TIGR00833 1303024005495 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024005496 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1303024005497 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1303024005498 active site 1303024005499 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1303024005500 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1303024005501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024005502 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1303024005503 Enoylreductase; Region: PKS_ER; smart00829 1303024005504 NAD(P) binding site [chemical binding]; other site 1303024005505 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1303024005506 KR domain; Region: KR; pfam08659 1303024005507 putative NADP binding site [chemical binding]; other site 1303024005508 active site 1303024005509 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1303024005510 Thioesterase domain; Region: Thioesterase; pfam00975 1303024005511 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1303024005512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024005513 dimer interface [polypeptide binding]; other site 1303024005514 conserved gate region; other site 1303024005515 putative PBP binding loops; other site 1303024005516 ABC-ATPase subunit interface; other site 1303024005517 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1303024005518 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1303024005519 Walker A/P-loop; other site 1303024005520 ATP binding site [chemical binding]; other site 1303024005521 Q-loop/lid; other site 1303024005522 ABC transporter signature motif; other site 1303024005523 Walker B; other site 1303024005524 D-loop; other site 1303024005525 H-loop/switch region; other site 1303024005526 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1303024005527 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1303024005528 substrate binding pocket [chemical binding]; other site 1303024005529 membrane-bound complex binding site; other site 1303024005530 hinge residues; other site 1303024005531 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1303024005532 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1303024005533 active site 1303024005534 dimer interface [polypeptide binding]; other site 1303024005535 non-prolyl cis peptide bond; other site 1303024005536 insertion regions; other site 1303024005537 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1303024005538 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1303024005539 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1303024005540 TspO/MBR family; Region: TspO_MBR; pfam03073 1303024005541 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1303024005542 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1303024005543 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1303024005544 active site 1303024005545 catalytic residues [active] 1303024005546 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1303024005547 EspG family; Region: ESX-1_EspG; pfam14011 1303024005548 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1303024005549 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1303024005550 PPE family; Region: PPE; pfam00823 1303024005551 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1303024005552 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024005553 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1303024005554 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024005555 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024005556 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1303024005557 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1303024005558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024005559 Walker A motif; other site 1303024005560 ATP binding site [chemical binding]; other site 1303024005561 Walker B motif; other site 1303024005562 arginine finger; other site 1303024005563 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1303024005564 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1303024005565 FAD binding pocket [chemical binding]; other site 1303024005566 FAD binding motif [chemical binding]; other site 1303024005567 phosphate binding motif [ion binding]; other site 1303024005568 NAD binding pocket [chemical binding]; other site 1303024005569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024005570 NAD(P) binding site [chemical binding]; other site 1303024005571 hypothetical protein; Provisional; Region: PRK07538 1303024005572 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024005573 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1303024005574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024005575 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1303024005576 putative dimerization interface [polypeptide binding]; other site 1303024005577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024005578 DNA-binding site [nucleotide binding]; DNA binding site 1303024005579 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1303024005580 UTRA domain; Region: UTRA; pfam07702 1303024005581 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1303024005582 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1303024005583 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1303024005584 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1303024005585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024005586 dimer interface [polypeptide binding]; other site 1303024005587 conserved gate region; other site 1303024005588 putative PBP binding loops; other site 1303024005589 ABC-ATPase subunit interface; other site 1303024005590 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1303024005591 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1303024005592 Walker A/P-loop; other site 1303024005593 ATP binding site [chemical binding]; other site 1303024005594 Q-loop/lid; other site 1303024005595 ABC transporter signature motif; other site 1303024005596 Walker B; other site 1303024005597 D-loop; other site 1303024005598 H-loop/switch region; other site 1303024005599 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1303024005600 L-aspartate oxidase; Provisional; Region: PRK06175 1303024005601 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1303024005602 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1303024005603 protein binding surface [polypeptide binding]; other site 1303024005604 salicylate synthase MbtI; Reviewed; Region: PRK07912 1303024005605 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1303024005606 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1303024005607 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1303024005608 DNA binding residues [nucleotide binding] 1303024005609 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1303024005610 catalytic triad [active] 1303024005611 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1303024005612 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1303024005613 acyl-activating enzyme (AAE) consensus motif; other site 1303024005614 active site 1303024005615 AMP binding site [chemical binding]; other site 1303024005616 substrate binding site [chemical binding]; other site 1303024005617 Condensation domain; Region: Condensation; pfam00668 1303024005618 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024005619 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024005620 acyl-activating enzyme (AAE) consensus motif; other site 1303024005621 AMP binding site [chemical binding]; other site 1303024005622 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024005623 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1303024005624 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1303024005625 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024005626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1303024005627 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1303024005628 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1303024005629 active site 1303024005630 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024005631 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1303024005632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1303024005633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024005634 Walker A/P-loop; other site 1303024005635 ATP binding site [chemical binding]; other site 1303024005636 Q-loop/lid; other site 1303024005637 ABC transporter signature motif; other site 1303024005638 Walker B; other site 1303024005639 D-loop; other site 1303024005640 H-loop/switch region; other site 1303024005641 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1303024005642 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1303024005643 FAD binding pocket [chemical binding]; other site 1303024005644 FAD binding motif [chemical binding]; other site 1303024005645 phosphate binding motif [ion binding]; other site 1303024005646 NAD binding pocket [chemical binding]; other site 1303024005647 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1303024005648 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1303024005649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024005650 Walker A/P-loop; other site 1303024005651 ATP binding site [chemical binding]; other site 1303024005652 Q-loop/lid; other site 1303024005653 ABC transporter signature motif; other site 1303024005654 Walker B; other site 1303024005655 D-loop; other site 1303024005656 H-loop/switch region; other site 1303024005657 metabolite-proton symporter; Region: 2A0106; TIGR00883 1303024005658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024005659 putative substrate translocation pore; other site 1303024005660 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1303024005661 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1303024005662 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1303024005663 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024005664 inhibitor-cofactor binding pocket; inhibition site 1303024005665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024005666 catalytic residue [active] 1303024005667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024005668 Coenzyme A binding pocket [chemical binding]; other site 1303024005669 Predicted membrane protein [Function unknown]; Region: COG1289 1303024005670 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1303024005671 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1303024005672 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1303024005673 DNA binding residues [nucleotide binding] 1303024005674 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1303024005675 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1303024005676 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1303024005677 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1303024005678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024005679 DNA-binding site [nucleotide binding]; DNA binding site 1303024005680 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1303024005681 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1303024005682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024005683 putative substrate translocation pore; other site 1303024005684 DoxX-like family; Region: DoxX_2; pfam13564 1303024005685 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1303024005686 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1303024005687 DNA binding site [nucleotide binding] 1303024005688 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1303024005689 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024005690 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1303024005691 NAD(P) binding site [chemical binding]; other site 1303024005692 catalytic residues [active] 1303024005693 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024005694 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024005695 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024005696 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1303024005697 inhibitor-cofactor binding pocket; inhibition site 1303024005698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024005699 catalytic residue [active] 1303024005700 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 1303024005701 putative hydrophobic ligand binding site [chemical binding]; other site 1303024005702 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1303024005703 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1303024005704 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1303024005705 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1303024005706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024005707 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1303024005708 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1303024005709 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1303024005710 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1303024005711 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024005712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024005713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024005714 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1303024005715 putative hydrophobic ligand binding site [chemical binding]; other site 1303024005716 protein interface [polypeptide binding]; other site 1303024005717 gate; other site 1303024005718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024005719 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024005720 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1303024005721 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024005722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024005723 Protease prsW family; Region: PrsW-protease; pfam13367 1303024005724 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1303024005725 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1303024005726 RNA binding site [nucleotide binding]; other site 1303024005727 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1303024005728 RNA binding site [nucleotide binding]; other site 1303024005729 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1303024005730 RNA binding site [nucleotide binding]; other site 1303024005731 S1 RNA binding domain; Region: S1; pfam00575 1303024005732 RNA binding site [nucleotide binding]; other site 1303024005733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1303024005734 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1303024005735 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1303024005736 CoA-binding site [chemical binding]; other site 1303024005737 ATP-binding [chemical binding]; other site 1303024005738 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1303024005739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024005740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024005741 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024005742 Transport protein; Region: actII; TIGR00833 1303024005743 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024005744 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1303024005745 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1303024005746 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1303024005747 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1303024005748 Protein of unknown function (DUF402); Region: DUF402; cl00979 1303024005749 excinuclease ABC subunit B; Provisional; Region: PRK05298 1303024005750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024005751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024005752 nucleotide binding region [chemical binding]; other site 1303024005753 ATP-binding site [chemical binding]; other site 1303024005754 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1303024005755 UvrB/uvrC motif; Region: UVR; pfam02151 1303024005756 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024005757 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1303024005758 DNA binding residues [nucleotide binding] 1303024005759 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1303024005760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024005761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024005762 putative substrate translocation pore; other site 1303024005763 hypothetical protein; Provisional; Region: PRK09133 1303024005764 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1303024005765 putative metal binding site [ion binding]; other site 1303024005766 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024005767 Ligand Binding Site [chemical binding]; other site 1303024005768 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1303024005769 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1303024005770 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1303024005771 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1303024005772 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1303024005773 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024005774 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1303024005775 acyl-activating enzyme (AAE) consensus motif; other site 1303024005776 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024005777 AMP binding site [chemical binding]; other site 1303024005778 active site 1303024005779 acyl-activating enzyme (AAE) consensus motif; other site 1303024005780 CoA binding site [chemical binding]; other site 1303024005781 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1303024005782 Putative esterase; Region: Esterase; pfam00756 1303024005783 Protein of unknown function (DUF585); Region: DUF585; pfam04522 1303024005784 S-formylglutathione hydrolase; Region: PLN02442 1303024005785 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1303024005786 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1303024005787 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1303024005788 dimer interface [polypeptide binding]; other site 1303024005789 putative anticodon binding site; other site 1303024005790 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1303024005791 motif 1; other site 1303024005792 dimer interface [polypeptide binding]; other site 1303024005793 active site 1303024005794 motif 2; other site 1303024005795 motif 3; other site 1303024005796 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1303024005797 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1303024005798 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1303024005799 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1303024005800 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1303024005801 23S rRNA binding site [nucleotide binding]; other site 1303024005802 L21 binding site [polypeptide binding]; other site 1303024005803 L13 binding site [polypeptide binding]; other site 1303024005804 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1303024005805 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1303024005806 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1303024005807 short chain dehydrogenase; Provisional; Region: PRK06197 1303024005808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024005809 NAD(P) binding site [chemical binding]; other site 1303024005810 active site 1303024005811 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 1303024005812 MspA; Region: MspA; pfam09203 1303024005813 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1303024005814 cyclase homology domain; Region: CHD; cd07302 1303024005815 nucleotidyl binding site; other site 1303024005816 metal binding site [ion binding]; metal-binding site 1303024005817 dimer interface [polypeptide binding]; other site 1303024005818 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1303024005819 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1303024005820 active site 1303024005821 DNA binding site [nucleotide binding] 1303024005822 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1303024005823 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1303024005824 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1303024005825 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1303024005826 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1303024005827 helix-hairpin-helix signature motif; other site 1303024005828 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1303024005829 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1303024005830 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1303024005831 dimer interface [polypeptide binding]; other site 1303024005832 motif 1; other site 1303024005833 active site 1303024005834 motif 2; other site 1303024005835 motif 3; other site 1303024005836 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1303024005837 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1303024005838 putative tRNA-binding site [nucleotide binding]; other site 1303024005839 B3/4 domain; Region: B3_4; pfam03483 1303024005840 tRNA synthetase B5 domain; Region: B5; smart00874 1303024005841 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1303024005842 dimer interface [polypeptide binding]; other site 1303024005843 motif 1; other site 1303024005844 motif 3; other site 1303024005845 motif 2; other site 1303024005846 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1303024005847 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1303024005848 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1303024005849 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1303024005850 heterotetramer interface [polypeptide binding]; other site 1303024005851 active site pocket [active] 1303024005852 cleavage site 1303024005853 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1303024005854 feedback inhibition sensing region; other site 1303024005855 homohexameric interface [polypeptide binding]; other site 1303024005856 nucleotide binding site [chemical binding]; other site 1303024005857 N-acetyl-L-glutamate binding site [chemical binding]; other site 1303024005858 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1303024005859 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024005860 inhibitor-cofactor binding pocket; inhibition site 1303024005861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024005862 catalytic residue [active] 1303024005863 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1303024005864 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1303024005865 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1303024005866 arginine repressor; Provisional; Region: PRK03341 1303024005867 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1303024005868 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1303024005869 argininosuccinate synthase; Provisional; Region: PRK13820 1303024005870 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1303024005871 ANP binding site [chemical binding]; other site 1303024005872 Substrate Binding Site II [chemical binding]; other site 1303024005873 Substrate Binding Site I [chemical binding]; other site 1303024005874 argininosuccinate lyase; Provisional; Region: PRK00855 1303024005875 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1303024005876 active sites [active] 1303024005877 tetramer interface [polypeptide binding]; other site 1303024005878 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1303024005879 acyl-CoA synthetase; Validated; Region: PRK07868 1303024005880 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024005881 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024005882 acyl-activating enzyme (AAE) consensus motif; other site 1303024005883 AMP binding site [chemical binding]; other site 1303024005884 active site 1303024005885 CoA binding site [chemical binding]; other site 1303024005886 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1303024005887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024005888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024005889 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1303024005890 active site 1303024005891 DNA binding site [nucleotide binding] 1303024005892 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1303024005893 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1303024005894 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1303024005895 active site 1303024005896 HIGH motif; other site 1303024005897 dimer interface [polypeptide binding]; other site 1303024005898 KMSKS motif; other site 1303024005899 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1303024005900 RNA binding surface [nucleotide binding]; other site 1303024005901 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1303024005902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024005903 Walker A/P-loop; other site 1303024005904 ATP binding site [chemical binding]; other site 1303024005905 Q-loop/lid; other site 1303024005906 ABC transporter signature motif; other site 1303024005907 Walker B; other site 1303024005908 D-loop; other site 1303024005909 H-loop/switch region; other site 1303024005910 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024005911 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1303024005912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024005913 active site 1303024005914 motif I; other site 1303024005915 motif II; other site 1303024005916 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1303024005917 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1303024005918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1303024005919 RNA binding surface [nucleotide binding]; other site 1303024005920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024005921 S-adenosylmethionine binding site [chemical binding]; other site 1303024005922 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1303024005923 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1303024005924 DNA repair protein RecN; Region: recN; TIGR00634 1303024005925 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1303024005926 Walker A/P-loop; other site 1303024005927 ATP binding site [chemical binding]; other site 1303024005928 Q-loop/lid; other site 1303024005929 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1303024005930 ABC transporter signature motif; other site 1303024005931 Walker B; other site 1303024005932 D-loop; other site 1303024005933 H-loop/switch region; other site 1303024005934 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1303024005935 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1303024005936 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1303024005937 CTP synthetase; Validated; Region: pyrG; PRK05380 1303024005938 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1303024005939 Catalytic site [active] 1303024005940 active site 1303024005941 UTP binding site [chemical binding]; other site 1303024005942 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1303024005943 active site 1303024005944 putative oxyanion hole; other site 1303024005945 catalytic triad [active] 1303024005946 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1303024005947 dimer interface [polypeptide binding]; other site 1303024005948 active site 1303024005949 ADP-ribose binding site [chemical binding]; other site 1303024005950 nudix motif; other site 1303024005951 metal binding site [ion binding]; metal-binding site 1303024005952 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1303024005953 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024005954 active site 1303024005955 DNA binding site [nucleotide binding] 1303024005956 Int/Topo IB signature motif; other site 1303024005957 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1303024005958 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024005959 P-loop; other site 1303024005960 Magnesium ion binding site [ion binding]; other site 1303024005961 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024005962 Magnesium ion binding site [ion binding]; other site 1303024005963 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1303024005964 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1303024005965 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1303024005966 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1303024005967 RNA binding surface [nucleotide binding]; other site 1303024005968 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1303024005969 active site 1303024005970 cytidylate kinase; Provisional; Region: cmk; PRK00023 1303024005971 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1303024005972 CMP-binding site; other site 1303024005973 The sites determining sugar specificity; other site 1303024005974 GTP-binding protein Der; Reviewed; Region: PRK03003 1303024005975 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1303024005976 G1 box; other site 1303024005977 GTP/Mg2+ binding site [chemical binding]; other site 1303024005978 Switch I region; other site 1303024005979 G2 box; other site 1303024005980 Switch II region; other site 1303024005981 G3 box; other site 1303024005982 G4 box; other site 1303024005983 G5 box; other site 1303024005984 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1303024005985 G1 box; other site 1303024005986 GTP/Mg2+ binding site [chemical binding]; other site 1303024005987 Switch I region; other site 1303024005988 G2 box; other site 1303024005989 G3 box; other site 1303024005990 Switch II region; other site 1303024005991 G4 box; other site 1303024005992 G5 box; other site 1303024005993 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1303024005994 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1303024005995 dimerization interface [polypeptide binding]; other site 1303024005996 mannose binding site [chemical binding]; other site 1303024005997 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1303024005998 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1303024005999 Amidohydrolase; Region: Amidohydro_2; pfam04909 1303024006000 Amidohydrolase; Region: Amidohydro_2; pfam04909 1303024006001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024006002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024006003 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1303024006004 substrate binding pocket [chemical binding]; other site 1303024006005 dimerization interface [polypeptide binding]; other site 1303024006006 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1303024006007 Phosphotransferase enzyme family; Region: APH; pfam01636 1303024006008 active site 1303024006009 ATP binding site [chemical binding]; other site 1303024006010 antibiotic binding site [chemical binding]; other site 1303024006011 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024006012 dimerization interface [polypeptide binding]; other site 1303024006013 putative DNA binding site [nucleotide binding]; other site 1303024006014 putative Zn2+ binding site [ion binding]; other site 1303024006015 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1303024006016 putative hydrophobic ligand binding site [chemical binding]; other site 1303024006017 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1303024006018 dimer interface [polypeptide binding]; other site 1303024006019 substrate binding site [chemical binding]; other site 1303024006020 metal binding site [ion binding]; metal-binding site 1303024006021 hypothetical protein; Validated; Region: PRK07121 1303024006022 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1303024006023 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024006024 ABC1 family; Region: ABC1; cl17513 1303024006025 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1303024006026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024006027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006028 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024006029 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1303024006030 active site 1303024006031 ATP binding site [chemical binding]; other site 1303024006032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024006033 Transposase; Region: HTH_Tnp_1; cl17663 1303024006034 putative transposase OrfB; Reviewed; Region: PHA02517 1303024006035 HTH-like domain; Region: HTH_21; pfam13276 1303024006036 Integrase core domain; Region: rve; pfam00665 1303024006037 Integrase core domain; Region: rve_3; pfam13683 1303024006038 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024006039 ABC1 family; Region: ABC1; cl17513 1303024006040 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1303024006041 hydrophobic ligand binding site; other site 1303024006042 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024006043 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024006044 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024006045 active site 1303024006046 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1303024006047 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1303024006048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1303024006049 nucleotide binding region [chemical binding]; other site 1303024006050 ATP-binding site [chemical binding]; other site 1303024006051 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1303024006052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1303024006053 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1303024006054 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1303024006055 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1303024006056 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1303024006057 lipoyl attachment site [posttranslational modification]; other site 1303024006058 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1303024006059 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1303024006060 phosphopeptide binding site; other site 1303024006061 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1303024006062 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1303024006063 DNA binding residues [nucleotide binding] 1303024006064 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1303024006065 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1303024006066 DNA binding residues [nucleotide binding] 1303024006067 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1303024006068 putative dimer interface [polypeptide binding]; other site 1303024006069 glycine dehydrogenase; Provisional; Region: PRK05367 1303024006070 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1303024006071 tetramer interface [polypeptide binding]; other site 1303024006072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024006073 catalytic residue [active] 1303024006074 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1303024006075 tetramer interface [polypeptide binding]; other site 1303024006076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024006077 catalytic residue [active] 1303024006078 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1303024006079 metal ion-dependent adhesion site (MIDAS); other site 1303024006080 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1303024006081 active site 1303024006082 Domain of unknown function DUF21; Region: DUF21; pfam01595 1303024006083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1303024006084 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1303024006085 Domain of unknown function DUF21; Region: DUF21; pfam01595 1303024006086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1303024006087 Transporter associated domain; Region: CorC_HlyC; smart01091 1303024006088 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1303024006089 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1303024006090 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1303024006091 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1303024006092 active site 1303024006093 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1303024006094 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1303024006095 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1303024006096 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1303024006097 Predicted transcriptional regulator [Transcription]; Region: COG3682 1303024006098 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024006099 CoenzymeA binding site [chemical binding]; other site 1303024006100 subunit interaction site [polypeptide binding]; other site 1303024006101 PHB binding site; other site 1303024006102 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024006103 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024006104 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024006105 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024006106 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1303024006107 alpha-gamma subunit interface [polypeptide binding]; other site 1303024006108 beta-gamma subunit interface [polypeptide binding]; other site 1303024006109 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1303024006110 gamma-beta subunit interface [polypeptide binding]; other site 1303024006111 alpha-beta subunit interface [polypeptide binding]; other site 1303024006112 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1303024006113 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1303024006114 subunit interactions [polypeptide binding]; other site 1303024006115 active site 1303024006116 flap region; other site 1303024006117 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1303024006118 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1303024006119 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1303024006120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024006121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024006122 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024006123 TIGR03086 family protein; Region: TIGR03086 1303024006124 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024006125 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1303024006126 short chain dehydrogenase; Provisional; Region: PRK05884 1303024006127 short chain dehydrogenase; Provisional; Region: PRK12939 1303024006128 NAD(P) binding site [chemical binding]; other site 1303024006129 active site 1303024006130 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1303024006131 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1303024006132 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1303024006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024006134 dimer interface [polypeptide binding]; other site 1303024006135 conserved gate region; other site 1303024006136 putative PBP binding loops; other site 1303024006137 ABC-ATPase subunit interface; other site 1303024006138 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1303024006139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024006140 Walker A/P-loop; other site 1303024006141 ATP binding site [chemical binding]; other site 1303024006142 Q-loop/lid; other site 1303024006143 ABC transporter signature motif; other site 1303024006144 Walker B; other site 1303024006145 D-loop; other site 1303024006146 H-loop/switch region; other site 1303024006147 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1303024006148 Predicted membrane protein [Function unknown]; Region: COG2261 1303024006149 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1303024006150 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1303024006151 molybdopterin cofactor binding site; other site 1303024006152 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1303024006153 molybdopterin cofactor binding site; other site 1303024006154 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1303024006155 Flavodoxin; Region: Flavodoxin_1; pfam00258 1303024006156 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1303024006157 FAD binding pocket [chemical binding]; other site 1303024006158 FAD binding motif [chemical binding]; other site 1303024006159 catalytic residues [active] 1303024006160 NAD binding pocket [chemical binding]; other site 1303024006161 phosphate binding motif [ion binding]; other site 1303024006162 beta-alpha-beta structure motif; other site 1303024006163 CrcB-like protein; Region: CRCB; pfam02537 1303024006164 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1303024006165 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006166 Ligand Binding Site [chemical binding]; other site 1303024006167 competence damage-inducible protein A; Provisional; Region: PRK00549 1303024006168 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1303024006169 putative MPT binding site; other site 1303024006170 Competence-damaged protein; Region: CinA; pfam02464 1303024006171 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1303024006172 Zn2+ binding site [ion binding]; other site 1303024006173 Mg2+ binding site [ion binding]; other site 1303024006174 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1303024006175 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1303024006176 conserved cys residue [active] 1303024006177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024006178 Pirin-related protein [General function prediction only]; Region: COG1741 1303024006179 Pirin; Region: Pirin; pfam02678 1303024006180 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1303024006181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024006182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006183 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 1303024006184 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1303024006185 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024006186 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024006187 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1303024006188 Predicted esterase [General function prediction only]; Region: COG0627 1303024006189 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1303024006190 active site 1303024006191 catalytic triad [active] 1303024006192 oxyanion hole [active] 1303024006193 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1303024006194 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1303024006195 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1303024006196 FAD binding domain; Region: FAD_binding_4; pfam01565 1303024006197 Berberine and berberine like; Region: BBE; pfam08031 1303024006198 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1303024006199 putative hydrophobic ligand binding site [chemical binding]; other site 1303024006200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024006201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006202 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1303024006203 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024006204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024006205 active site 1303024006206 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1303024006207 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1303024006208 Walker A/P-loop; other site 1303024006209 ATP binding site [chemical binding]; other site 1303024006210 Q-loop/lid; other site 1303024006211 ABC transporter signature motif; other site 1303024006212 Walker B; other site 1303024006213 D-loop; other site 1303024006214 H-loop/switch region; other site 1303024006215 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1303024006216 NMT1-like family; Region: NMT1_2; pfam13379 1303024006217 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1303024006218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024006219 dimer interface [polypeptide binding]; other site 1303024006220 conserved gate region; other site 1303024006221 putative PBP binding loops; other site 1303024006222 ABC-ATPase subunit interface; other site 1303024006223 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1303024006224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024006225 substrate binding site [chemical binding]; other site 1303024006226 oxyanion hole (OAH) forming residues; other site 1303024006227 trimer interface [polypeptide binding]; other site 1303024006228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006229 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1303024006230 heme bH binding site [chemical binding]; other site 1303024006231 Qi binding site; other site 1303024006232 intrachain domain interface; other site 1303024006233 heme bL binding site [chemical binding]; other site 1303024006234 interchain domain interface [polypeptide binding]; other site 1303024006235 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1303024006236 Qo binding site; other site 1303024006237 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1303024006238 active site 1303024006239 barstar interaction site; other site 1303024006240 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 1303024006241 putative RNAase interaction site [polypeptide binding]; other site 1303024006242 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1303024006243 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1303024006244 heme binding site [chemical binding]; other site 1303024006245 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1303024006246 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1303024006247 metal binding site 2 [ion binding]; metal-binding site 1303024006248 putative DNA binding helix; other site 1303024006249 metal binding site 1 [ion binding]; metal-binding site 1303024006250 dimer interface [polypeptide binding]; other site 1303024006251 structural Zn2+ binding site [ion binding]; other site 1303024006252 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024006253 MarR family; Region: MarR; pfam01047 1303024006254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1303024006255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024006256 Coenzyme A binding pocket [chemical binding]; other site 1303024006257 NlpC/P60 family; Region: NLPC_P60; pfam00877 1303024006258 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1303024006259 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1303024006260 putative hydrophobic ligand binding site [chemical binding]; other site 1303024006261 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1303024006262 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024006263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024006264 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1303024006265 hydrophobic ligand binding site; other site 1303024006266 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1303024006267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024006268 metabolite-proton symporter; Region: 2A0106; TIGR00883 1303024006269 putative substrate translocation pore; other site 1303024006270 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1303024006271 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1303024006272 active site 1303024006273 non-prolyl cis peptide bond; other site 1303024006274 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1303024006275 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1303024006276 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1303024006277 Flavodoxin; Region: Flavodoxin_1; pfam00258 1303024006278 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1303024006279 FAD binding pocket [chemical binding]; other site 1303024006280 FAD binding motif [chemical binding]; other site 1303024006281 catalytic residues [active] 1303024006282 NAD binding pocket [chemical binding]; other site 1303024006283 phosphate binding motif [ion binding]; other site 1303024006284 beta-alpha-beta structure motif; other site 1303024006285 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1303024006286 dimer interface [polypeptide binding]; other site 1303024006287 active site 1303024006288 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1303024006289 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1303024006290 active site 1303024006291 FMN binding site [chemical binding]; other site 1303024006292 substrate binding site [chemical binding]; other site 1303024006293 3Fe-4S cluster binding site [ion binding]; other site 1303024006294 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1303024006295 domain_subunit interface; other site 1303024006296 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006297 Ligand Binding Site [chemical binding]; other site 1303024006298 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006299 Ligand Binding Site [chemical binding]; other site 1303024006300 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1303024006301 Flavodoxin; Region: Flavodoxin_1; pfam00258 1303024006302 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1303024006303 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1303024006304 FAD binding pocket [chemical binding]; other site 1303024006305 FAD binding motif [chemical binding]; other site 1303024006306 catalytic residues [active] 1303024006307 NAD binding pocket [chemical binding]; other site 1303024006308 phosphate binding motif [ion binding]; other site 1303024006309 beta-alpha-beta structure motif; other site 1303024006310 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1303024006311 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1303024006312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024006313 active site 1303024006314 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1303024006315 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024006316 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1303024006317 active site 1303024006318 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1303024006319 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1303024006320 nucleotide binding site [chemical binding]; other site 1303024006321 SBD interface [polypeptide binding]; other site 1303024006322 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1303024006323 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024006324 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1303024006325 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1303024006326 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1303024006327 active site 1303024006328 DNA binding site [nucleotide binding] 1303024006329 Int/Topo IB signature motif; other site 1303024006330 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1303024006331 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1303024006332 iron-sulfur cluster [ion binding]; other site 1303024006333 [2Fe-2S] cluster binding site [ion binding]; other site 1303024006334 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1303024006335 putative phosphoketolase; Provisional; Region: PRK05261 1303024006336 XFP N-terminal domain; Region: XFP_N; pfam09364 1303024006337 XFP C-terminal domain; Region: XFP_C; pfam09363 1303024006338 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1303024006339 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1303024006340 ligand binding site [chemical binding]; other site 1303024006341 flexible hinge region; other site 1303024006342 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1303024006343 putative switch regulator; other site 1303024006344 non-specific DNA interactions [nucleotide binding]; other site 1303024006345 DNA binding site [nucleotide binding] 1303024006346 sequence specific DNA binding site [nucleotide binding]; other site 1303024006347 putative cAMP binding site [chemical binding]; other site 1303024006348 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1303024006349 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1303024006350 putative methyltransferase; Provisional; Region: PRK14967 1303024006351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024006352 S-adenosylmethionine binding site [chemical binding]; other site 1303024006353 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1303024006354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024006355 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1303024006356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024006357 DNA binding residues [nucleotide binding] 1303024006358 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1303024006359 anti sigma factor interaction site; other site 1303024006360 regulatory phosphorylation site [posttranslational modification]; other site 1303024006361 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1303024006362 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1303024006363 active site 1303024006364 metal binding site [ion binding]; metal-binding site 1303024006365 Low affinity iron permease; Region: Iron_permease; cl12096 1303024006366 Low affinity iron permease; Region: Iron_permease; cl12096 1303024006367 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1303024006368 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1303024006369 PAS fold; Region: PAS_3; pfam08447 1303024006370 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1303024006371 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1303024006372 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024006373 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1303024006374 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1303024006375 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1303024006376 putative ADP-binding pocket [chemical binding]; other site 1303024006377 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1303024006378 active site 1303024006379 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1303024006380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024006381 NAD(P) binding site [chemical binding]; other site 1303024006382 active site 1303024006383 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1303024006384 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1303024006385 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1303024006386 active site 1303024006387 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1303024006388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024006389 active site 1303024006390 motif I; other site 1303024006391 motif II; other site 1303024006392 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1303024006393 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1303024006394 putative active site [active] 1303024006395 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1303024006396 dimer interface [polypeptide binding]; other site 1303024006397 active site 1303024006398 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1303024006399 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1303024006400 substrate binding site [chemical binding]; other site 1303024006401 ATP binding site [chemical binding]; other site 1303024006402 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1303024006403 active site 1303024006404 nucleotide binding site [chemical binding]; other site 1303024006405 HIGH motif; other site 1303024006406 KMSKS motif; other site 1303024006407 short chain dehydrogenase; Provisional; Region: PRK08219 1303024006408 classical (c) SDRs; Region: SDR_c; cd05233 1303024006409 NAD(P) binding site [chemical binding]; other site 1303024006410 active site 1303024006411 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1303024006412 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1303024006413 putative active site [active] 1303024006414 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1303024006415 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1303024006416 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1303024006417 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1303024006418 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1303024006419 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024006420 catalytic residue [active] 1303024006421 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1303024006422 PhoU domain; Region: PhoU; pfam01895 1303024006423 PhoU domain; Region: PhoU; pfam01895 1303024006424 LGFP repeat; Region: LGFP; pfam08310 1303024006425 ChaB; Region: ChaB; pfam06150 1303024006426 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1303024006427 hydroperoxidase II; Provisional; Region: katE; PRK11249 1303024006428 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1303024006429 tetramer interface [polypeptide binding]; other site 1303024006430 heme binding pocket [chemical binding]; other site 1303024006431 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1303024006432 domain interactions; other site 1303024006433 GAF domain; Region: GAF_2; pfam13185 1303024006434 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1303024006435 putative proline-specific permease; Provisional; Region: proY; PRK10580 1303024006436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024006437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006438 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1303024006439 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1303024006440 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1303024006441 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1303024006442 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1303024006443 active site 1303024006444 catalytic triad [active] 1303024006445 dimer interface [polypeptide binding]; other site 1303024006446 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1303024006447 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1303024006448 active site 1303024006449 Cupin domain; Region: Cupin_2; pfam07883 1303024006450 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024006451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024006452 S-adenosylmethionine binding site [chemical binding]; other site 1303024006453 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1303024006454 homodimer interface [polypeptide binding]; other site 1303024006455 putative substrate binding pocket [chemical binding]; other site 1303024006456 diiron center [ion binding]; other site 1303024006457 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1303024006458 TOBE domain; Region: TOBE; cl01440 1303024006459 Cellulose binding domain; Region: CBM_2; pfam00553 1303024006460 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1303024006461 Isochorismatase family; Region: Isochorismatase; pfam00857 1303024006462 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1303024006463 catalytic triad [active] 1303024006464 conserved cis-peptide bond; other site 1303024006465 carboxylate-amine ligase; Provisional; Region: PRK13517 1303024006466 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1303024006467 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1303024006468 LGFP repeat; Region: LGFP; pfam08310 1303024006469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024006470 dimerization interface [polypeptide binding]; other site 1303024006471 putative DNA binding site [nucleotide binding]; other site 1303024006472 putative Zn2+ binding site [ion binding]; other site 1303024006473 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1303024006474 active site clefts [active] 1303024006475 zinc binding site [ion binding]; other site 1303024006476 dimer interface [polypeptide binding]; other site 1303024006477 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024006478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024006479 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006480 Ligand Binding Site [chemical binding]; other site 1303024006481 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006482 Ligand Binding Site [chemical binding]; other site 1303024006483 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006484 Ligand Binding Site [chemical binding]; other site 1303024006485 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1303024006486 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1303024006487 putative NAD(P) binding site [chemical binding]; other site 1303024006488 putative substrate binding site [chemical binding]; other site 1303024006489 catalytic Zn binding site [ion binding]; other site 1303024006490 structural Zn binding site [ion binding]; other site 1303024006491 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1303024006492 dimer interface [polypeptide binding]; other site 1303024006493 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006494 Ligand Binding Site [chemical binding]; other site 1303024006495 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006496 Ligand Binding Site [chemical binding]; other site 1303024006497 putative phosphoketolase; Provisional; Region: PRK05261 1303024006498 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1303024006499 TPP-binding site; other site 1303024006500 XFP C-terminal domain; Region: XFP_C; pfam09363 1303024006501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024006502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024006503 active site 1303024006504 phosphorylation site [posttranslational modification] 1303024006505 intermolecular recognition site; other site 1303024006506 dimerization interface [polypeptide binding]; other site 1303024006507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024006508 DNA binding residues [nucleotide binding] 1303024006509 dimerization interface [polypeptide binding]; other site 1303024006510 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1303024006511 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1303024006512 GAF domain; Region: GAF_3; pfam13492 1303024006513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1303024006514 Histidine kinase; Region: HisKA_3; pfam07730 1303024006515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024006516 ATP binding site [chemical binding]; other site 1303024006517 Mg2+ binding site [ion binding]; other site 1303024006518 G-X-G motif; other site 1303024006519 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1303024006520 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1303024006521 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1303024006522 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1303024006523 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1303024006524 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1303024006525 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006526 Ligand Binding Site [chemical binding]; other site 1303024006527 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006528 Ligand Binding Site [chemical binding]; other site 1303024006529 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024006530 Ligand Binding Site [chemical binding]; other site 1303024006531 Predicted membrane protein [Function unknown]; Region: COG3462 1303024006532 Short C-terminal domain; Region: SHOCT; pfam09851 1303024006533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024006534 dimerization interface [polypeptide binding]; other site 1303024006535 putative DNA binding site [nucleotide binding]; other site 1303024006536 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1303024006537 putative Zn2+ binding site [ion binding]; other site 1303024006538 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1303024006539 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024006540 putative metal binding site [ion binding]; other site 1303024006541 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1303024006542 arsenical-resistance protein; Region: acr3; TIGR00832 1303024006543 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1303024006544 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1303024006545 active site 1303024006546 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1303024006547 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024006548 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024006549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024006550 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1303024006551 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1303024006552 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1303024006553 active site 1303024006554 metal binding site [ion binding]; metal-binding site 1303024006555 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 1303024006556 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024006557 putative active site [active] 1303024006558 putative metal binding site [ion binding]; other site 1303024006559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006560 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1303024006561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024006562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006563 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1303024006564 homotrimer interaction site [polypeptide binding]; other site 1303024006565 putative active site [active] 1303024006566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024006567 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1303024006568 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024006569 active site 1303024006570 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1303024006571 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1303024006572 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1303024006573 active site 1303024006574 Fe binding site [ion binding]; other site 1303024006575 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1303024006576 Predicted membrane protein [Function unknown]; Region: COG4270 1303024006577 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1303024006578 classical (c) SDRs; Region: SDR_c; cd05233 1303024006579 NAD(P) binding site [chemical binding]; other site 1303024006580 active site 1303024006581 AAA domain; Region: AAA_23; pfam13476 1303024006582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024006583 Walker A/P-loop; other site 1303024006584 ATP binding site [chemical binding]; other site 1303024006585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024006586 ABC transporter signature motif; other site 1303024006587 Walker B; other site 1303024006588 D-loop; other site 1303024006589 H-loop/switch region; other site 1303024006590 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1303024006591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024006592 ATP binding site [chemical binding]; other site 1303024006593 putative Mg++ binding site [ion binding]; other site 1303024006594 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1303024006595 DNA methylase; Region: N6_N4_Mtase; pfam01555 1303024006596 DNA methylase; Region: N6_N4_Mtase; cl17433 1303024006597 putative transposase OrfB; Reviewed; Region: PHA02517 1303024006598 HTH-like domain; Region: HTH_21; pfam13276 1303024006599 Integrase core domain; Region: rve; pfam00665 1303024006600 Integrase core domain; Region: rve_3; pfam13683 1303024006601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024006602 Transposase; Region: HTH_Tnp_1; cl17663 1303024006603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024006604 salt bridge; other site 1303024006605 non-specific DNA binding site [nucleotide binding]; other site 1303024006606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024006607 sequence-specific DNA binding site [nucleotide binding]; other site 1303024006608 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024006609 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024006610 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1303024006611 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1303024006612 PAS fold; Region: PAS_3; pfam08447 1303024006613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1303024006614 putative active site [active] 1303024006615 heme pocket [chemical binding]; other site 1303024006616 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1303024006617 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1303024006618 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1303024006619 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1303024006620 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1303024006621 active site 1303024006622 NodB motif; other site 1303024006623 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1303024006624 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1303024006625 hypothetical protein; Provisional; Region: PRK02237 1303024006626 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1303024006627 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1303024006628 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1303024006629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024006630 dimerization interface [polypeptide binding]; other site 1303024006631 putative DNA binding site [nucleotide binding]; other site 1303024006632 putative Zn2+ binding site [ion binding]; other site 1303024006633 Cation efflux family; Region: Cation_efflux; cl00316 1303024006634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024006635 putative DNA binding site [nucleotide binding]; other site 1303024006636 putative Zn2+ binding site [ion binding]; other site 1303024006637 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1303024006638 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024006639 active site 1303024006640 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024006641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024006642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006643 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 1303024006644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024006645 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024006646 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024006647 acyl-CoA synthetase; Provisional; Region: PRK13388 1303024006648 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024006649 acyl-activating enzyme (AAE) consensus motif; other site 1303024006650 AMP binding site [chemical binding]; other site 1303024006651 active site 1303024006652 CoA binding site [chemical binding]; other site 1303024006653 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1303024006654 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1303024006655 inhibitor-cofactor binding pocket; inhibition site 1303024006656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024006657 catalytic residue [active] 1303024006658 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1303024006659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024006660 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1303024006661 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1303024006662 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1303024006663 hypothetical protein; Provisional; Region: PRK06185 1303024006664 hypothetical protein; Provisional; Region: PRK07236 1303024006665 DNA polymerase I; Provisional; Region: PRK05755 1303024006666 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1303024006667 active site 1303024006668 metal binding site 1 [ion binding]; metal-binding site 1303024006669 putative 5' ssDNA interaction site; other site 1303024006670 metal binding site 3; metal-binding site 1303024006671 metal binding site 2 [ion binding]; metal-binding site 1303024006672 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1303024006673 putative DNA binding site [nucleotide binding]; other site 1303024006674 putative metal binding site [ion binding]; other site 1303024006675 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1303024006676 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1303024006677 active site 1303024006678 DNA binding site [nucleotide binding] 1303024006679 catalytic site [active] 1303024006680 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1303024006681 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024006682 active site 1303024006683 metal binding site [ion binding]; metal-binding site 1303024006684 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1303024006685 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1303024006686 D-pathway; other site 1303024006687 Putative ubiquinol binding site [chemical binding]; other site 1303024006688 Low-spin heme (heme b) binding site [chemical binding]; other site 1303024006689 Putative water exit pathway; other site 1303024006690 Binuclear center (heme o3/CuB) [ion binding]; other site 1303024006691 K-pathway; other site 1303024006692 Putative proton exit pathway; other site 1303024006693 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1303024006694 DUF35 OB-fold domain; Region: DUF35; pfam01796 1303024006695 lipid-transfer protein; Provisional; Region: PRK06059 1303024006696 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024006697 active site 1303024006698 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1303024006699 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1303024006700 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1303024006701 Walker A/P-loop; other site 1303024006702 ATP binding site [chemical binding]; other site 1303024006703 Q-loop/lid; other site 1303024006704 ABC transporter signature motif; other site 1303024006705 Walker B; other site 1303024006706 D-loop; other site 1303024006707 H-loop/switch region; other site 1303024006708 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1303024006709 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1303024006710 Walker A/P-loop; other site 1303024006711 ATP binding site [chemical binding]; other site 1303024006712 Q-loop/lid; other site 1303024006713 ABC transporter signature motif; other site 1303024006714 Walker B; other site 1303024006715 D-loop; other site 1303024006716 H-loop/switch region; other site 1303024006717 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1303024006718 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1303024006719 TM-ABC transporter signature motif; other site 1303024006720 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1303024006721 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1303024006722 TM-ABC transporter signature motif; other site 1303024006723 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1303024006724 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1303024006725 dimerization interface [polypeptide binding]; other site 1303024006726 ligand binding site [chemical binding]; other site 1303024006727 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1303024006728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024006729 active site 1303024006730 phosphorylation site [posttranslational modification] 1303024006731 intermolecular recognition site; other site 1303024006732 dimerization interface [polypeptide binding]; other site 1303024006733 ANTAR domain; Region: ANTAR; pfam03861 1303024006734 SnoaL-like domain; Region: SnoaL_4; pfam13577 1303024006735 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1303024006736 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1303024006737 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1303024006738 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1303024006739 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1303024006740 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1303024006741 Walker A/P-loop; other site 1303024006742 ATP binding site [chemical binding]; other site 1303024006743 Q-loop/lid; other site 1303024006744 ABC transporter signature motif; other site 1303024006745 Walker B; other site 1303024006746 D-loop; other site 1303024006747 H-loop/switch region; other site 1303024006748 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1303024006749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024006750 Walker A/P-loop; other site 1303024006751 ATP binding site [chemical binding]; other site 1303024006752 Q-loop/lid; other site 1303024006753 ABC transporter signature motif; other site 1303024006754 Walker B; other site 1303024006755 D-loop; other site 1303024006756 H-loop/switch region; other site 1303024006757 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1303024006758 Na binding site [ion binding]; other site 1303024006759 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1303024006760 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1303024006761 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1303024006762 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1303024006763 active site 1303024006764 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1303024006765 catalytic triad [active] 1303024006766 dimer interface [polypeptide binding]; other site 1303024006767 pyruvate kinase; Provisional; Region: PRK06247 1303024006768 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1303024006769 domain interfaces; other site 1303024006770 active site 1303024006771 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1303024006772 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 1303024006773 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1303024006774 substrate binding site [chemical binding]; other site 1303024006775 active site 1303024006776 catalytic residues [active] 1303024006777 heterodimer interface [polypeptide binding]; other site 1303024006778 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1303024006779 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1303024006780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024006781 catalytic residue [active] 1303024006782 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1303024006783 active site 1303024006784 ribulose/triose binding site [chemical binding]; other site 1303024006785 phosphate binding site [ion binding]; other site 1303024006786 substrate (anthranilate) binding pocket [chemical binding]; other site 1303024006787 product (indole) binding pocket [chemical binding]; other site 1303024006788 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1303024006789 anthranilate synthase component I; Provisional; Region: PRK13571 1303024006790 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1303024006791 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1303024006792 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024006793 MarR family; Region: MarR_2; pfam12802 1303024006794 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024006795 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1303024006796 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1303024006797 HIT family signature motif; other site 1303024006798 catalytic residue [active] 1303024006799 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1303024006800 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1303024006801 catalytic triad [active] 1303024006802 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1303024006803 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1303024006804 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1303024006805 substrate binding site [chemical binding]; other site 1303024006806 glutamase interaction surface [polypeptide binding]; other site 1303024006807 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1303024006808 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1303024006809 active site 1303024006810 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1303024006811 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1303024006812 catalytic residues [active] 1303024006813 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1303024006814 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1303024006815 putative active site [active] 1303024006816 oxyanion strand; other site 1303024006817 catalytic triad [active] 1303024006818 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1303024006819 putative active site pocket [active] 1303024006820 4-fold oligomerization interface [polypeptide binding]; other site 1303024006821 metal binding residues [ion binding]; metal-binding site 1303024006822 3-fold/trimer interface [polypeptide binding]; other site 1303024006823 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1303024006824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024006825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024006826 homodimer interface [polypeptide binding]; other site 1303024006827 catalytic residue [active] 1303024006828 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1303024006829 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1303024006830 NAD binding site [chemical binding]; other site 1303024006831 dimerization interface [polypeptide binding]; other site 1303024006832 product binding site; other site 1303024006833 substrate binding site [chemical binding]; other site 1303024006834 zinc binding site [ion binding]; other site 1303024006835 catalytic residues [active] 1303024006836 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024006837 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1303024006838 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1303024006839 dimerization interface [polypeptide binding]; other site 1303024006840 active site 1303024006841 L-aspartate oxidase; Provisional; Region: PRK07804 1303024006842 L-aspartate oxidase; Provisional; Region: PRK06175 1303024006843 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1303024006844 quinolinate synthetase; Provisional; Region: PRK09375 1303024006845 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1303024006846 nudix motif; other site 1303024006847 Secretory lipase; Region: LIP; pfam03583 1303024006848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024006849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006850 hypothetical protein; Provisional; Region: PRK07588 1303024006851 hypothetical protein; Provisional; Region: PRK07236 1303024006852 hypothetical protein; Provisional; Region: PRK07236 1303024006853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024006854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024006855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1303024006856 dimerization interface [polypeptide binding]; other site 1303024006857 malate:quinone oxidoreductase; Validated; Region: PRK05257 1303024006858 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1303024006859 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1303024006860 biotin synthase; Validated; Region: PRK06256 1303024006861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024006862 FeS/SAM binding site; other site 1303024006863 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1303024006864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024006865 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1303024006866 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1303024006867 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1303024006868 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1303024006869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024006870 catalytic residue [active] 1303024006871 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1303024006872 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024006873 inhibitor-cofactor binding pocket; inhibition site 1303024006874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024006875 catalytic residue [active] 1303024006876 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1303024006877 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1303024006878 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1303024006879 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1303024006880 active site 1303024006881 catalytic site [active] 1303024006882 threonine dehydratase; Validated; Region: PRK08639 1303024006883 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1303024006884 tetramer interface [polypeptide binding]; other site 1303024006885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024006886 catalytic residue [active] 1303024006887 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1303024006888 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024006889 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1303024006890 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1303024006891 active site 1303024006892 PHP Thumb interface [polypeptide binding]; other site 1303024006893 metal binding site [ion binding]; metal-binding site 1303024006894 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1303024006895 generic binding surface II; other site 1303024006896 generic binding surface I; other site 1303024006897 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1303024006898 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1303024006899 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1303024006900 active site 1303024006901 lipoprotein signal peptidase; Provisional; Region: PRK14764 1303024006902 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1303024006903 active site 1303024006904 homotetramer interface [polypeptide binding]; other site 1303024006905 homodimer interface [polypeptide binding]; other site 1303024006906 DNA polymerase IV; Provisional; Region: PRK03348 1303024006907 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1303024006908 active site 1303024006909 DNA binding site [nucleotide binding] 1303024006910 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024006911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024006912 S-adenosylmethionine binding site [chemical binding]; other site 1303024006913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1303024006914 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1303024006915 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1303024006916 HIGH motif; other site 1303024006917 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1303024006918 active site 1303024006919 KMSKS motif; other site 1303024006920 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1303024006921 tRNA binding surface [nucleotide binding]; other site 1303024006922 anticodon binding site; other site 1303024006923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024006924 putative substrate translocation pore; other site 1303024006925 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1303024006926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024006927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024006928 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1303024006929 putative dimerization interface [polypeptide binding]; other site 1303024006930 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1303024006931 metal binding triad; other site 1303024006932 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1303024006933 active site 1303024006934 catalytic site [active] 1303024006935 substrate binding site [chemical binding]; other site 1303024006936 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1303024006937 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1303024006938 Walker A; other site 1303024006939 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1303024006940 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1303024006941 active site 1303024006942 substrate binding site [chemical binding]; other site 1303024006943 coenzyme B12 binding site [chemical binding]; other site 1303024006944 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1303024006945 B12 binding site [chemical binding]; other site 1303024006946 cobalt ligand [ion binding]; other site 1303024006947 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1303024006948 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1303024006949 heterodimer interface [polypeptide binding]; other site 1303024006950 substrate interaction site [chemical binding]; other site 1303024006951 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1303024006952 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1303024006953 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1303024006954 DoxX-like family; Region: DoxX_2; pfam13564 1303024006955 DoxX-like family; Region: DoxX_2; pfam13564 1303024006956 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1303024006957 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1303024006958 Protein of unknown function (DUF1616); Region: DUF1616; cl01959 1303024006959 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1303024006960 MgtE intracellular N domain; Region: MgtE_N; smart00924 1303024006961 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1303024006962 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1303024006963 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1303024006964 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1303024006965 ferrochelatase; Reviewed; Region: hemH; PRK00035 1303024006966 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1303024006967 C-terminal domain interface [polypeptide binding]; other site 1303024006968 active site 1303024006969 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1303024006970 active site 1303024006971 N-terminal domain interface [polypeptide binding]; other site 1303024006972 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1303024006973 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1303024006974 NAD binding site [chemical binding]; other site 1303024006975 homotetramer interface [polypeptide binding]; other site 1303024006976 homodimer interface [polypeptide binding]; other site 1303024006977 substrate binding site [chemical binding]; other site 1303024006978 active site 1303024006979 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1303024006980 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1303024006981 NAD(P) binding site [chemical binding]; other site 1303024006982 homotetramer interface [polypeptide binding]; other site 1303024006983 homodimer interface [polypeptide binding]; other site 1303024006984 active site 1303024006985 hypothetical protein; Provisional; Region: PRK13685 1303024006986 Aerotolerance regulator N-terminal; Region: BatA; cl06567 1303024006987 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1303024006988 metal ion-dependent adhesion site (MIDAS); other site 1303024006989 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1303024006990 Protein of unknown function DUF58; Region: DUF58; pfam01882 1303024006991 MoxR-like ATPases [General function prediction only]; Region: COG0714 1303024006992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024006993 Walker A motif; other site 1303024006994 ATP binding site [chemical binding]; other site 1303024006995 Walker B motif; other site 1303024006996 arginine finger; other site 1303024006997 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1303024006998 NlpC/P60 family; Region: NLPC_P60; pfam00877 1303024006999 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1303024007000 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1303024007001 NlpC/P60 family; Region: NLPC_P60; pfam00877 1303024007002 aconitate hydratase; Validated; Region: PRK09277 1303024007003 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1303024007004 substrate binding site [chemical binding]; other site 1303024007005 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1303024007006 ligand binding site [chemical binding]; other site 1303024007007 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1303024007008 substrate binding site [chemical binding]; other site 1303024007009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024007010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024007011 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1303024007012 AMIN domain; Region: AMIN; pfam11741 1303024007013 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1303024007014 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1303024007015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024007016 Walker A/P-loop; other site 1303024007017 ATP binding site [chemical binding]; other site 1303024007018 Q-loop/lid; other site 1303024007019 ABC transporter signature motif; other site 1303024007020 Walker B; other site 1303024007021 D-loop; other site 1303024007022 H-loop/switch region; other site 1303024007023 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024007024 enoyl-CoA hydratase; Provisional; Region: PRK05864 1303024007025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024007026 substrate binding site [chemical binding]; other site 1303024007027 oxyanion hole (OAH) forming residues; other site 1303024007028 trimer interface [polypeptide binding]; other site 1303024007029 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1303024007030 catalytic residues [active] 1303024007031 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1303024007032 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1303024007033 putative active site [active] 1303024007034 putative FMN binding site [chemical binding]; other site 1303024007035 putative substrate binding site [chemical binding]; other site 1303024007036 putative catalytic residue [active] 1303024007037 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1303024007038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024007039 Coenzyme A binding pocket [chemical binding]; other site 1303024007040 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 1303024007041 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1303024007042 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1303024007043 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1303024007044 trimerization site [polypeptide binding]; other site 1303024007045 active site 1303024007046 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1303024007047 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1303024007048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024007049 catalytic residue [active] 1303024007050 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1303024007051 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1303024007052 Walker A/P-loop; other site 1303024007053 ATP binding site [chemical binding]; other site 1303024007054 Q-loop/lid; other site 1303024007055 ABC transporter signature motif; other site 1303024007056 Walker B; other site 1303024007057 D-loop; other site 1303024007058 H-loop/switch region; other site 1303024007059 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1303024007060 FeS assembly protein SufD; Region: sufD; TIGR01981 1303024007061 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1303024007062 FeS assembly protein SufB; Region: sufB; TIGR01980 1303024007063 Predicted transcriptional regulator [Transcription]; Region: COG2345 1303024007064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024007065 putative DNA binding site [nucleotide binding]; other site 1303024007066 putative Zn2+ binding site [ion binding]; other site 1303024007067 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1303024007068 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1303024007069 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1303024007070 Walker A/P-loop; other site 1303024007071 ATP binding site [chemical binding]; other site 1303024007072 Q-loop/lid; other site 1303024007073 ABC transporter signature motif; other site 1303024007074 Walker B; other site 1303024007075 D-loop; other site 1303024007076 H-loop/switch region; other site 1303024007077 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1303024007078 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1303024007079 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1303024007080 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1303024007081 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1303024007082 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1303024007083 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1303024007084 NADP binding site [chemical binding]; other site 1303024007085 dimer interface [polypeptide binding]; other site 1303024007086 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1303024007087 UbiA prenyltransferase family; Region: UbiA; pfam01040 1303024007088 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1303024007089 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1303024007090 TPP-binding site [chemical binding]; other site 1303024007091 dimer interface [polypeptide binding]; other site 1303024007092 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1303024007093 PYR/PP interface [polypeptide binding]; other site 1303024007094 dimer interface [polypeptide binding]; other site 1303024007095 TPP binding site [chemical binding]; other site 1303024007096 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1303024007097 putative active site [active] 1303024007098 transaldolase; Provisional; Region: PRK03903 1303024007099 catalytic residue [active] 1303024007100 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1303024007101 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1303024007102 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1303024007103 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1303024007104 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1303024007105 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1303024007106 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1303024007107 putative active site [active] 1303024007108 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1303024007109 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1303024007110 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1303024007111 triosephosphate isomerase; Provisional; Region: PRK14567 1303024007112 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1303024007113 substrate binding site [chemical binding]; other site 1303024007114 dimer interface [polypeptide binding]; other site 1303024007115 catalytic triad [active] 1303024007116 Phosphoglycerate kinase; Region: PGK; pfam00162 1303024007117 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1303024007118 substrate binding site [chemical binding]; other site 1303024007119 hinge regions; other site 1303024007120 ADP binding site [chemical binding]; other site 1303024007121 catalytic site [active] 1303024007122 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1303024007123 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1303024007124 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1303024007125 H+ Antiporter protein; Region: 2A0121; TIGR00900 1303024007126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024007127 putative substrate translocation pore; other site 1303024007128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1303024007129 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1303024007130 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1303024007131 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1303024007132 phosphate binding site [ion binding]; other site 1303024007133 putative substrate binding pocket [chemical binding]; other site 1303024007134 dimer interface [polypeptide binding]; other site 1303024007135 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1303024007136 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1303024007137 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1303024007138 GIY-YIG motif/motif A; other site 1303024007139 active site 1303024007140 catalytic site [active] 1303024007141 putative DNA binding site [nucleotide binding]; other site 1303024007142 metal binding site [ion binding]; metal-binding site 1303024007143 UvrB/uvrC motif; Region: UVR; pfam02151 1303024007144 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1303024007145 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1303024007146 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1303024007147 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1303024007148 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1303024007149 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1303024007150 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1303024007151 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1303024007152 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1303024007153 ethanolamine permease; Region: 2A0305; TIGR00908 1303024007154 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1303024007155 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024007156 NAD(P) binding site [chemical binding]; other site 1303024007157 catalytic residues [active] 1303024007158 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1303024007159 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1303024007160 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1303024007161 homopentamer interface [polypeptide binding]; other site 1303024007162 active site 1303024007163 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1303024007164 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1303024007165 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1303024007166 dimerization interface [polypeptide binding]; other site 1303024007167 active site 1303024007168 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1303024007169 Lumazine binding domain; Region: Lum_binding; pfam00677 1303024007170 Lumazine binding domain; Region: Lum_binding; pfam00677 1303024007171 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024007172 MspA; Region: MspA; pfam09203 1303024007173 MspA; Region: MspA; pfam09203 1303024007174 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1303024007175 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1303024007176 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1303024007177 Walker A/P-loop; other site 1303024007178 ATP binding site [chemical binding]; other site 1303024007179 Q-loop/lid; other site 1303024007180 ABC transporter signature motif; other site 1303024007181 Walker B; other site 1303024007182 D-loop; other site 1303024007183 H-loop/switch region; other site 1303024007184 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1303024007185 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1303024007186 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1303024007187 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1303024007188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024007189 putative substrate translocation pore; other site 1303024007190 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1303024007191 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1303024007192 catalytic motif [active] 1303024007193 Zn binding site [ion binding]; other site 1303024007194 RibD C-terminal domain; Region: RibD_C; pfam01872 1303024007195 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1303024007196 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1303024007197 substrate binding site [chemical binding]; other site 1303024007198 hexamer interface [polypeptide binding]; other site 1303024007199 metal binding site [ion binding]; metal-binding site 1303024007200 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1303024007201 putative RNA binding site [nucleotide binding]; other site 1303024007202 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1303024007203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024007204 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1303024007205 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1303024007206 putative active site [active] 1303024007207 substrate binding site [chemical binding]; other site 1303024007208 putative cosubstrate binding site; other site 1303024007209 catalytic site [active] 1303024007210 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1303024007211 substrate binding site [chemical binding]; other site 1303024007212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024007213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024007214 primosome assembly protein PriA; Provisional; Region: PRK14873 1303024007215 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024007216 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024007217 substrate binding pocket [chemical binding]; other site 1303024007218 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024007219 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1303024007220 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1303024007221 Na binding site [ion binding]; other site 1303024007222 putative substrate binding site [chemical binding]; other site 1303024007223 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024007224 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 1303024007225 phenylhydantoinase; Validated; Region: PRK08323 1303024007226 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1303024007227 tetramer interface [polypeptide binding]; other site 1303024007228 active site 1303024007229 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1303024007230 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1303024007231 active site 1303024007232 catalytic triad [active] 1303024007233 dimer interface [polypeptide binding]; other site 1303024007234 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 1303024007235 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1303024007236 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1303024007237 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1303024007238 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1303024007239 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1303024007240 Flavoprotein; Region: Flavoprotein; pfam02441 1303024007241 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1303024007242 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1303024007243 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1303024007244 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1303024007245 catalytic site [active] 1303024007246 G-X2-G-X-G-K; other site 1303024007247 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1303024007248 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1303024007249 active site 1303024007250 dimer interface [polypeptide binding]; other site 1303024007251 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1303024007252 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1303024007253 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1303024007254 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1303024007255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1303024007256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1303024007257 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1303024007258 IMP binding site; other site 1303024007259 dimer interface [polypeptide binding]; other site 1303024007260 interdomain contacts; other site 1303024007261 partial ornithine binding site; other site 1303024007262 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1303024007263 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1303024007264 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1303024007265 catalytic site [active] 1303024007266 subunit interface [polypeptide binding]; other site 1303024007267 dihydroorotase; Validated; Region: pyrC; PRK09357 1303024007268 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024007269 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1303024007270 active site 1303024007271 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1303024007272 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1303024007273 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1303024007274 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1303024007275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1303024007276 active site 1303024007277 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024007278 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024007279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024007280 S-adenosylmethionine binding site [chemical binding]; other site 1303024007281 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024007282 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1303024007283 elongation factor P; Validated; Region: PRK00529 1303024007284 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1303024007285 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1303024007286 RNA binding site [nucleotide binding]; other site 1303024007287 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1303024007288 RNA binding site [nucleotide binding]; other site 1303024007289 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1303024007290 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1303024007291 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1303024007292 active site 1303024007293 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1303024007294 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1303024007295 trimer interface [polypeptide binding]; other site 1303024007296 active site 1303024007297 dimer interface [polypeptide binding]; other site 1303024007298 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1303024007299 active site 1303024007300 dimer interface [polypeptide binding]; other site 1303024007301 metal binding site [ion binding]; metal-binding site 1303024007302 shikimate kinase; Reviewed; Region: aroK; PRK00131 1303024007303 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1303024007304 ADP binding site [chemical binding]; other site 1303024007305 magnesium binding site [ion binding]; other site 1303024007306 putative shikimate binding site; other site 1303024007307 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1303024007308 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1303024007309 Tetramer interface [polypeptide binding]; other site 1303024007310 active site 1303024007311 FMN-binding site [chemical binding]; other site 1303024007312 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1303024007313 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1303024007314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024007315 S-adenosylmethionine binding site [chemical binding]; other site 1303024007316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024007317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024007318 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1303024007319 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1303024007320 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1303024007321 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1303024007322 shikimate binding site; other site 1303024007323 NAD(P) binding site [chemical binding]; other site 1303024007324 YceG-like family; Region: YceG; pfam02618 1303024007325 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1303024007326 dimerization interface [polypeptide binding]; other site 1303024007327 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1303024007328 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1303024007329 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1303024007330 motif 1; other site 1303024007331 active site 1303024007332 motif 2; other site 1303024007333 motif 3; other site 1303024007334 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1303024007335 DHHA1 domain; Region: DHHA1; pfam02272 1303024007336 recombination factor protein RarA; Reviewed; Region: PRK13342 1303024007337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024007338 Walker A motif; other site 1303024007339 ATP binding site [chemical binding]; other site 1303024007340 Walker B motif; other site 1303024007341 arginine finger; other site 1303024007342 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1303024007343 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1303024007344 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1303024007345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1303024007346 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1303024007347 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1303024007348 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1303024007349 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1303024007350 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1303024007351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1303024007352 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1303024007353 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1303024007354 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1303024007355 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1303024007356 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1303024007357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1303024007358 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024007359 Predicted permease; Region: DUF318; cl17795 1303024007360 TIGR03943 family protein; Region: TIGR03943 1303024007361 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1303024007362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024007363 motif II; other site 1303024007364 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1303024007365 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1303024007366 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1303024007367 dimer interface [polypeptide binding]; other site 1303024007368 anticodon binding site; other site 1303024007369 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1303024007370 homodimer interface [polypeptide binding]; other site 1303024007371 motif 1; other site 1303024007372 active site 1303024007373 motif 2; other site 1303024007374 GAD domain; Region: GAD; pfam02938 1303024007375 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1303024007376 active site 1303024007377 motif 3; other site 1303024007378 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1303024007379 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024007380 substrate binding pocket [chemical binding]; other site 1303024007381 catalytic triad [active] 1303024007382 Predicted metalloprotease [General function prediction only]; Region: COG2321 1303024007383 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1303024007384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024007385 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1303024007386 FeS/SAM binding site; other site 1303024007387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024007388 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1303024007389 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1303024007390 putative active site pocket [active] 1303024007391 dimerization interface [polypeptide binding]; other site 1303024007392 putative catalytic residue [active] 1303024007393 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1303024007394 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1303024007395 dimer interface [polypeptide binding]; other site 1303024007396 motif 1; other site 1303024007397 active site 1303024007398 motif 2; other site 1303024007399 motif 3; other site 1303024007400 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1303024007401 anticodon binding site; other site 1303024007402 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1303024007403 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1303024007404 active site 1303024007405 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1303024007406 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1303024007407 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1303024007408 Zn2+ binding site [ion binding]; other site 1303024007409 Mg2+ binding site [ion binding]; other site 1303024007410 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1303024007411 synthetase active site [active] 1303024007412 NTP binding site [chemical binding]; other site 1303024007413 metal binding site [ion binding]; metal-binding site 1303024007414 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1303024007415 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1303024007416 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1303024007417 active site 1303024007418 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1303024007419 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1303024007420 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1303024007421 Protein export membrane protein; Region: SecD_SecF; pfam02355 1303024007422 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1303024007423 Protein export membrane protein; Region: SecD_SecF; cl14618 1303024007424 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1303024007425 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1303024007426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024007427 Walker A motif; other site 1303024007428 ATP binding site [chemical binding]; other site 1303024007429 Walker B motif; other site 1303024007430 arginine finger; other site 1303024007431 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1303024007432 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1303024007433 RuvA N terminal domain; Region: RuvA_N; pfam01330 1303024007434 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1303024007435 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1303024007436 active site 1303024007437 putative DNA-binding cleft [nucleotide binding]; other site 1303024007438 dimer interface [polypeptide binding]; other site 1303024007439 calcium/proton exchanger (cax); Region: cax; TIGR00378 1303024007440 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1303024007441 active site 1303024007442 hypothetical protein; Validated; Region: PRK00110 1303024007443 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1303024007444 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 1303024007445 predicted active site [active] 1303024007446 catalytic triad [active] 1303024007447 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1303024007448 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1303024007449 active site 1303024007450 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1303024007451 catalytic triad [active] 1303024007452 dimer interface [polypeptide binding]; other site 1303024007453 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1303024007454 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1303024007455 active site 1303024007456 multimer interface [polypeptide binding]; other site 1303024007457 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1303024007458 nudix motif; other site 1303024007459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024007460 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1303024007461 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1303024007462 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1303024007463 putative acyl-acceptor binding pocket; other site 1303024007464 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1303024007465 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1303024007466 nucleotide binding site/active site [active] 1303024007467 HIT family signature motif; other site 1303024007468 catalytic residue [active] 1303024007469 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1303024007470 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1303024007471 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1303024007472 active site 1303024007473 dimer interface [polypeptide binding]; other site 1303024007474 motif 1; other site 1303024007475 motif 2; other site 1303024007476 motif 3; other site 1303024007477 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1303024007478 anticodon binding site; other site 1303024007479 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1303024007480 conserved cys residue [active] 1303024007481 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1303024007482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024007483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024007484 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1303024007485 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1303024007486 conserved cys residue [active] 1303024007487 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024007488 CoenzymeA binding site [chemical binding]; other site 1303024007489 subunit interaction site [polypeptide binding]; other site 1303024007490 PHB binding site; other site 1303024007491 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1303024007492 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1303024007493 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1303024007494 NAD(P) binding site [chemical binding]; other site 1303024007495 catalytic residues [active] 1303024007496 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024007497 AMP binding site [chemical binding]; other site 1303024007498 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 1303024007499 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1303024007500 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1303024007501 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1303024007502 homotrimer interaction site [polypeptide binding]; other site 1303024007503 putative active site [active] 1303024007504 hypothetical protein; Provisional; Region: PRK06208 1303024007505 intersubunit interface [polypeptide binding]; other site 1303024007506 active site 1303024007507 Zn2+ binding site [ion binding]; other site 1303024007508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024007509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024007510 L-asparagine permease; Provisional; Region: PRK15049 1303024007511 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1303024007512 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1303024007513 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1303024007514 putative active site [active] 1303024007515 catalytic triad [active] 1303024007516 putative dimer interface [polypeptide binding]; other site 1303024007517 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1303024007518 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1303024007519 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1303024007520 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1303024007521 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1303024007522 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024007523 catalytic loop [active] 1303024007524 iron binding site [ion binding]; other site 1303024007525 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1303024007526 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1303024007527 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1303024007528 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1303024007529 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1303024007530 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1303024007531 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1303024007532 active site 1303024007533 putative substrate binding pocket [chemical binding]; other site 1303024007534 guanine deaminase; Provisional; Region: PRK09228 1303024007535 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024007536 active site 1303024007537 urate oxidase; Region: urate_oxi; TIGR03383 1303024007538 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1303024007539 active site 1303024007540 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1303024007541 active site 1303024007542 homotetramer interface [polypeptide binding]; other site 1303024007543 putative OHCU decarboxylase; Provisional; Region: PRK13798 1303024007544 xanthine permease; Region: pbuX; TIGR03173 1303024007545 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1303024007546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024007547 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1303024007548 DNA-binding site [nucleotide binding]; DNA binding site 1303024007549 FCD domain; Region: FCD; pfam07729 1303024007550 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1303024007551 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1303024007552 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1303024007553 active site 1303024007554 catalytic site [active] 1303024007555 tetramer interface [polypeptide binding]; other site 1303024007556 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1303024007557 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1303024007558 Na binding site [ion binding]; other site 1303024007559 putative substrate binding site [chemical binding]; other site 1303024007560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1303024007561 active site 1303024007562 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1303024007563 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1303024007564 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1303024007565 allantoicase; Provisional; Region: PRK13257 1303024007566 Allantoicase repeat; Region: Allantoicase; pfam03561 1303024007567 Allantoicase repeat; Region: Allantoicase; pfam03561 1303024007568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1303024007569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1303024007570 active site 1303024007571 catalytic tetrad [active] 1303024007572 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024007573 short chain dehydrogenase; Provisional; Region: PRK06181 1303024007574 classical (c) SDRs; Region: SDR_c; cd05233 1303024007575 NAD(P) binding site [chemical binding]; other site 1303024007576 active site 1303024007577 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1303024007578 mce related protein; Region: MCE; pfam02470 1303024007579 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024007580 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024007581 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024007582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024007583 active site 1303024007584 short chain dehydrogenase; Provisional; Region: PRK07791 1303024007585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024007586 NAD(P) binding site [chemical binding]; other site 1303024007587 active site 1303024007588 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1303024007589 active site 1303024007590 catalytic site [active] 1303024007591 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024007592 active site 2 [active] 1303024007593 active site 1 [active] 1303024007594 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1303024007595 hydrophobic ligand binding site; other site 1303024007596 lipid-transfer protein; Provisional; Region: PRK08256 1303024007597 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024007598 active site 1303024007599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024007600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024007601 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1303024007602 Peptidase family M48; Region: Peptidase_M48; pfam01435 1303024007603 Yqey-like protein; Region: YqeY; cl17540 1303024007604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024007605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024007606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024007607 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024007608 putative substrate translocation pore; other site 1303024007609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1303024007610 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024007611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024007612 S-adenosylmethionine binding site [chemical binding]; other site 1303024007613 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1303024007614 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024007615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024007616 acyl-activating enzyme (AAE) consensus motif; other site 1303024007617 acyl-activating enzyme (AAE) consensus motif; other site 1303024007618 AMP binding site [chemical binding]; other site 1303024007619 active site 1303024007620 CoA binding site [chemical binding]; other site 1303024007621 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1303024007622 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1303024007623 putative NAD(P) binding site [chemical binding]; other site 1303024007624 active site 1303024007625 putative substrate binding site [chemical binding]; other site 1303024007626 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1303024007627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024007628 acyl-activating enzyme (AAE) consensus motif; other site 1303024007629 AMP binding site [chemical binding]; other site 1303024007630 active site 1303024007631 CoA binding site [chemical binding]; other site 1303024007632 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1303024007633 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1303024007634 putative NAD(P) binding site [chemical binding]; other site 1303024007635 active site 1303024007636 putative substrate binding site [chemical binding]; other site 1303024007637 SnoaL-like domain; Region: SnoaL_2; pfam12680 1303024007638 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1303024007639 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024007640 active site 1303024007641 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024007642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024007643 catalytic loop [active] 1303024007644 iron binding site [ion binding]; other site 1303024007645 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024007646 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024007647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024007648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024007649 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024007650 ABC1 family; Region: ABC1; pfam03109 1303024007651 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 1303024007652 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1303024007653 hydrophobic ligand binding site; other site 1303024007654 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1303024007655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024007656 NAD(P) binding site [chemical binding]; other site 1303024007657 active site 1303024007658 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1303024007659 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1303024007660 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1303024007661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1303024007662 Walker A motif; other site 1303024007663 ATP binding site [chemical binding]; other site 1303024007664 Walker B motif; other site 1303024007665 hypothetical protein; Provisional; Region: PRK14059 1303024007666 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1303024007667 TAP-like protein; Region: Abhydrolase_4; pfam08386 1303024007668 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1303024007669 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1303024007670 SelR domain; Region: SelR; pfam01641 1303024007671 MFS transport protein AraJ; Provisional; Region: PRK10091 1303024007672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024007673 putative substrate translocation pore; other site 1303024007674 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1303024007675 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1303024007676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024007677 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1303024007678 substrate binding site [chemical binding]; other site 1303024007679 active site 1303024007680 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1303024007681 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1303024007682 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1303024007683 catalytic site [active] 1303024007684 putative active site [active] 1303024007685 putative substrate binding site [chemical binding]; other site 1303024007686 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1303024007687 Chloramphenicol acetyltransferase; Region: CAT; cl02008 1303024007688 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1303024007689 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1303024007690 TPP-binding site; other site 1303024007691 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1303024007692 PYR/PP interface [polypeptide binding]; other site 1303024007693 dimer interface [polypeptide binding]; other site 1303024007694 TPP binding site [chemical binding]; other site 1303024007695 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1303024007696 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 1303024007697 TRAM domain; Region: TRAM; pfam01938 1303024007698 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1303024007699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1303024007700 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1303024007701 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1303024007702 TrkA-N domain; Region: TrkA_N; pfam02254 1303024007703 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1303024007704 TrkA-N domain; Region: TrkA_N; pfam02254 1303024007705 TrkA-C domain; Region: TrkA_C; pfam02080 1303024007706 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1303024007707 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1303024007708 generic binding surface II; other site 1303024007709 ssDNA binding site; other site 1303024007710 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1303024007711 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024007712 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1303024007713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024007714 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1303024007715 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1303024007716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024007717 NAD(P) binding site [chemical binding]; other site 1303024007718 active site 1303024007719 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024007720 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1303024007721 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1303024007722 trimer interface [polypeptide binding]; other site 1303024007723 active site 1303024007724 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1303024007725 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1303024007726 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1303024007727 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1303024007728 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1303024007729 active site 1303024007730 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1303024007731 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1303024007732 nucleotide binding site [chemical binding]; other site 1303024007733 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1303024007734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024007735 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1303024007736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024007737 DNA binding residues [nucleotide binding] 1303024007738 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1303024007739 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1303024007740 DNA binding site [nucleotide binding] 1303024007741 active site 1303024007742 Predicted membrane protein [Function unknown]; Region: COG3918 1303024007743 mercuric reductase; Validated; Region: PRK06370 1303024007744 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024007745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024007746 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1303024007747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024007748 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1303024007749 active site 1303024007750 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1303024007751 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024007752 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1303024007753 homotrimer interaction site [polypeptide binding]; other site 1303024007754 putative active site [active] 1303024007755 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1303024007756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024007757 DNA-binding site [nucleotide binding]; DNA binding site 1303024007758 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1303024007759 hypothetical protein; Provisional; Region: PRK05409 1303024007760 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1303024007761 Protein of unknown function (DUF952); Region: DUF952; cl01393 1303024007762 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1303024007763 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1303024007764 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1303024007765 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1303024007766 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1303024007767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024007768 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1303024007769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024007770 DNA binding residues [nucleotide binding] 1303024007771 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1303024007772 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1303024007773 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1303024007774 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1303024007775 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1303024007776 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1303024007777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024007778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024007779 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1303024007780 PAC2 family; Region: PAC2; pfam09754 1303024007781 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024007782 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024007783 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1303024007784 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1303024007785 ATP cone domain; Region: ATP-cone; pfam03477 1303024007786 LysM domain; Region: LysM; pfam01476 1303024007787 LexA repressor; Validated; Region: PRK00215 1303024007788 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1303024007789 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1303024007790 Catalytic site [active] 1303024007791 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1303024007792 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1303024007793 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024007794 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024007795 active site 1303024007796 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1303024007797 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1303024007798 molybdopterin cofactor binding site [chemical binding]; other site 1303024007799 substrate binding site [chemical binding]; other site 1303024007800 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1303024007801 molybdopterin cofactor binding site; other site 1303024007802 GTPases [General function prediction only]; Region: HflX; COG2262 1303024007803 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1303024007804 HflX GTPase family; Region: HflX; cd01878 1303024007805 G1 box; other site 1303024007806 GTP/Mg2+ binding site [chemical binding]; other site 1303024007807 Switch I region; other site 1303024007808 G2 box; other site 1303024007809 G3 box; other site 1303024007810 Switch II region; other site 1303024007811 G4 box; other site 1303024007812 G5 box; other site 1303024007813 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1303024007814 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1303024007815 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1303024007816 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1303024007817 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1303024007818 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1303024007819 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1303024007820 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1303024007821 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1303024007822 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1303024007823 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1303024007824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024007825 FeS/SAM binding site; other site 1303024007826 Dehydratase family; Region: ILVD_EDD; cl00340 1303024007827 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1303024007828 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1303024007829 Walker A/P-loop; other site 1303024007830 ATP binding site [chemical binding]; other site 1303024007831 Q-loop/lid; other site 1303024007832 ABC transporter signature motif; other site 1303024007833 Walker B; other site 1303024007834 D-loop; other site 1303024007835 H-loop/switch region; other site 1303024007836 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1303024007837 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1303024007838 substrate binding pocket [chemical binding]; other site 1303024007839 membrane-bound complex binding site; other site 1303024007840 hinge residues; other site 1303024007841 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1303024007842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024007843 dimer interface [polypeptide binding]; other site 1303024007844 conserved gate region; other site 1303024007845 putative PBP binding loops; other site 1303024007846 ABC-ATPase subunit interface; other site 1303024007847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024007848 dimer interface [polypeptide binding]; other site 1303024007849 conserved gate region; other site 1303024007850 putative PBP binding loops; other site 1303024007851 ABC-ATPase subunit interface; other site 1303024007852 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1303024007853 SnoaL-like domain; Region: SnoaL_2; pfam12680 1303024007854 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024007855 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024007856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024007857 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1303024007858 active site 1303024007859 metal binding site [ion binding]; metal-binding site 1303024007860 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1303024007861 CGNR zinc finger; Region: zf-CGNR; pfam11706 1303024007862 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1303024007863 recombinase A; Provisional; Region: recA; PRK09354 1303024007864 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1303024007865 hexamer interface [polypeptide binding]; other site 1303024007866 Walker A motif; other site 1303024007867 ATP binding site [chemical binding]; other site 1303024007868 Walker B motif; other site 1303024007869 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1303024007870 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1303024007871 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1303024007872 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1303024007873 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1303024007874 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1303024007875 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1303024007876 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024007877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024007878 non-specific DNA binding site [nucleotide binding]; other site 1303024007879 salt bridge; other site 1303024007880 sequence-specific DNA binding site [nucleotide binding]; other site 1303024007881 Helix-turn-helix domain; Region: HTH_31; pfam13560 1303024007882 short chain dehydrogenase; Provisional; Region: PRK05854 1303024007883 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1303024007884 putative NAD(P) binding site [chemical binding]; other site 1303024007885 active site 1303024007886 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1303024007887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024007888 Coenzyme A binding pocket [chemical binding]; other site 1303024007889 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1303024007890 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1303024007891 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1303024007892 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024007893 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1303024007894 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1303024007895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024007896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024007897 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1303024007898 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1303024007899 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1303024007900 classical (c) SDRs; Region: SDR_c; cd05233 1303024007901 NAD(P) binding site [chemical binding]; other site 1303024007902 active site 1303024007903 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024007904 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1303024007905 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1303024007906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024007907 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1303024007908 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1303024007909 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1303024007910 dimer interface [polypeptide binding]; other site 1303024007911 active site 1303024007912 catalytic residue [active] 1303024007913 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1303024007914 YceI-like domain; Region: YceI; pfam04264 1303024007915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1303024007916 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1303024007917 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1303024007918 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1303024007919 catalytic residues [active] 1303024007920 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1303024007921 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1303024007922 folate binding site [chemical binding]; other site 1303024007923 NADP+ binding site [chemical binding]; other site 1303024007924 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1303024007925 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1303024007926 dimerization interface [polypeptide binding]; other site 1303024007927 active site 1303024007928 acyltransferase PapA5; Provisional; Region: PRK09294 1303024007929 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1303024007930 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1303024007931 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1303024007932 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1303024007933 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1303024007934 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1303024007935 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1303024007936 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1303024007937 Carbonic anhydrase; Region: Pro_CA; smart00947 1303024007938 active site clefts [active] 1303024007939 zinc binding site [ion binding]; other site 1303024007940 dimer interface [polypeptide binding]; other site 1303024007941 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1303024007942 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1303024007943 AsnC family; Region: AsnC_trans_reg; pfam01037 1303024007944 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1303024007945 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1303024007946 hexamer interface [polypeptide binding]; other site 1303024007947 ligand binding site [chemical binding]; other site 1303024007948 putative active site [active] 1303024007949 NAD(P) binding site [chemical binding]; other site 1303024007950 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024007951 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024007952 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1303024007953 classical (c) SDRs; Region: SDR_c; cd05233 1303024007954 NAD(P) binding site [chemical binding]; other site 1303024007955 active site 1303024007956 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1303024007957 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1303024007958 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1303024007959 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1303024007960 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1303024007961 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1303024007962 oligomer interface [polypeptide binding]; other site 1303024007963 RNA binding site [nucleotide binding]; other site 1303024007964 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1303024007965 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1303024007966 RNase E interface [polypeptide binding]; other site 1303024007967 trimer interface [polypeptide binding]; other site 1303024007968 active site 1303024007969 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1303024007970 putative nucleic acid binding region [nucleotide binding]; other site 1303024007971 G-X-X-G motif; other site 1303024007972 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1303024007973 RNA binding site [nucleotide binding]; other site 1303024007974 domain interface; other site 1303024007975 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1303024007976 16S/18S rRNA binding site [nucleotide binding]; other site 1303024007977 S13e-L30e interaction site [polypeptide binding]; other site 1303024007978 25S rRNA binding site [nucleotide binding]; other site 1303024007979 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1303024007980 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1303024007981 active site 1303024007982 Riboflavin kinase; Region: Flavokinase; pfam01687 1303024007983 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1303024007984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024007985 putative DNA binding site [nucleotide binding]; other site 1303024007986 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1303024007987 FeoA domain; Region: FeoA; pfam04023 1303024007988 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1303024007989 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1303024007990 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1303024007991 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1303024007992 RNA binding site [nucleotide binding]; other site 1303024007993 active site 1303024007994 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1303024007995 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1303024007996 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1303024007997 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1303024007998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1303024007999 active site 1303024008000 metal binding site [ion binding]; metal-binding site 1303024008001 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1303024008002 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1303024008003 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1303024008004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024008005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024008006 active site 1303024008007 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024008008 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024008009 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1303024008010 active site 1303024008011 enoyl-CoA hydratase; Provisional; Region: PRK06190 1303024008012 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024008013 substrate binding site [chemical binding]; other site 1303024008014 oxyanion hole (OAH) forming residues; other site 1303024008015 trimer interface [polypeptide binding]; other site 1303024008016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1303024008017 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1303024008018 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1303024008019 putative efflux protein, MATE family; Region: matE; TIGR00797 1303024008020 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1303024008021 DHH family; Region: DHH; pfam01368 1303024008022 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1303024008023 translation initiation factor IF-2; Region: IF-2; TIGR00487 1303024008024 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1303024008025 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1303024008026 G1 box; other site 1303024008027 putative GEF interaction site [polypeptide binding]; other site 1303024008028 GTP/Mg2+ binding site [chemical binding]; other site 1303024008029 Switch I region; other site 1303024008030 G2 box; other site 1303024008031 G3 box; other site 1303024008032 Switch II region; other site 1303024008033 G4 box; other site 1303024008034 G5 box; other site 1303024008035 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1303024008036 Translation-initiation factor 2; Region: IF-2; pfam11987 1303024008037 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1303024008038 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1303024008039 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1303024008040 heme-binding site [chemical binding]; other site 1303024008041 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1303024008042 FAD binding pocket [chemical binding]; other site 1303024008043 FAD binding motif [chemical binding]; other site 1303024008044 phosphate binding motif [ion binding]; other site 1303024008045 beta-alpha-beta structure motif; other site 1303024008046 NAD binding pocket [chemical binding]; other site 1303024008047 Rrf2 family protein; Region: rrf2_super; TIGR00738 1303024008048 Transcriptional regulator; Region: Rrf2; cl17282 1303024008049 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1303024008050 NusA N-terminal domain; Region: NusA_N; pfam08529 1303024008051 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1303024008052 RNA binding site [nucleotide binding]; other site 1303024008053 homodimer interface [polypeptide binding]; other site 1303024008054 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1303024008055 G-X-X-G motif; other site 1303024008056 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1303024008057 G-X-X-G motif; other site 1303024008058 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1303024008059 Sm and related proteins; Region: Sm_like; cl00259 1303024008060 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1303024008061 putative oligomer interface [polypeptide binding]; other site 1303024008062 putative RNA binding site [nucleotide binding]; other site 1303024008063 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1303024008064 dinuclear metal binding motif [ion binding]; other site 1303024008065 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1303024008066 putative hydrophobic ligand binding site [chemical binding]; other site 1303024008067 protein interface [polypeptide binding]; other site 1303024008068 gate; other site 1303024008069 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1303024008070 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1303024008071 dimer interface [polypeptide binding]; other site 1303024008072 motif 1; other site 1303024008073 active site 1303024008074 motif 2; other site 1303024008075 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1303024008076 putative deacylase active site [active] 1303024008077 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1303024008078 active site 1303024008079 motif 3; other site 1303024008080 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1303024008081 anticodon binding site; other site 1303024008082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024008083 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024008084 putative substrate translocation pore; other site 1303024008085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024008086 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1303024008087 siroheme synthase; Provisional; Region: cysG; PRK10637 1303024008088 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1303024008089 active site 1303024008090 SAM binding site [chemical binding]; other site 1303024008091 homodimer interface [polypeptide binding]; other site 1303024008092 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1303024008093 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1303024008094 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1303024008095 Walker A/P-loop; other site 1303024008096 ATP binding site [chemical binding]; other site 1303024008097 Q-loop/lid; other site 1303024008098 ABC transporter signature motif; other site 1303024008099 Walker B; other site 1303024008100 D-loop; other site 1303024008101 H-loop/switch region; other site 1303024008102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024008103 Walker A/P-loop; other site 1303024008104 ATP binding site [chemical binding]; other site 1303024008105 Q-loop/lid; other site 1303024008106 ABC transporter signature motif; other site 1303024008107 Walker B; other site 1303024008108 D-loop; other site 1303024008109 H-loop/switch region; other site 1303024008110 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1303024008111 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1303024008112 Condensation domain; Region: Condensation; pfam00668 1303024008113 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1303024008114 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1303024008115 active site 1303024008116 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1303024008117 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1303024008118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024008119 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1303024008120 Enoylreductase; Region: PKS_ER; smart00829 1303024008121 NAD(P) binding site [chemical binding]; other site 1303024008122 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1303024008123 KR domain; Region: KR; pfam08659 1303024008124 putative NADP binding site [chemical binding]; other site 1303024008125 active site 1303024008126 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1303024008127 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024008128 Transport protein; Region: actII; TIGR00833 1303024008129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008131 MspA; Region: MspA; pfam09203 1303024008132 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1303024008133 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1303024008134 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1303024008135 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1303024008136 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 1303024008137 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1303024008138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024008139 Walker A motif; other site 1303024008140 ATP binding site [chemical binding]; other site 1303024008141 Walker B motif; other site 1303024008142 arginine finger; other site 1303024008143 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1303024008144 metal ion-dependent adhesion site (MIDAS); other site 1303024008145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1303024008146 malate:quinone oxidoreductase; Validated; Region: PRK05257 1303024008147 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1303024008148 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1303024008149 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024008150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024008151 cobyric acid synthase; Provisional; Region: PRK00784 1303024008152 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1303024008153 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1303024008154 catalytic triad [active] 1303024008155 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1303024008156 active site 1303024008157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1303024008158 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1303024008159 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1303024008160 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1303024008161 active site 1303024008162 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1303024008163 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1303024008164 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1303024008165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1303024008166 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1303024008167 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1303024008168 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1303024008169 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1303024008170 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1303024008171 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1303024008172 active site 1303024008173 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1303024008174 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1303024008175 putative substrate binding region [chemical binding]; other site 1303024008176 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1303024008177 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1303024008178 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1303024008179 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1303024008180 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1303024008181 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1303024008182 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1303024008183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024008184 FeS/SAM binding site; other site 1303024008185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024008186 non-specific DNA binding site [nucleotide binding]; other site 1303024008187 salt bridge; other site 1303024008188 sequence-specific DNA binding site [nucleotide binding]; other site 1303024008189 Cupin domain; Region: Cupin_2; pfam07883 1303024008190 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1303024008191 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024008192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024008193 S-adenosylmethionine binding site [chemical binding]; other site 1303024008194 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024008195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024008196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1303024008197 dimerization interface [polypeptide binding]; other site 1303024008198 EamA-like transporter family; Region: EamA; pfam00892 1303024008199 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1303024008200 Dienelactone hydrolase family; Region: DLH; pfam01738 1303024008201 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1303024008202 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1303024008203 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1303024008204 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1303024008205 hinge region; other site 1303024008206 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1303024008207 putative nucleotide binding site [chemical binding]; other site 1303024008208 uridine monophosphate binding site [chemical binding]; other site 1303024008209 homohexameric interface [polypeptide binding]; other site 1303024008210 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1303024008211 Part of AAA domain; Region: AAA_19; pfam13245 1303024008212 Family description; Region: UvrD_C_2; pfam13538 1303024008213 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1303024008214 hypothetical protein; Provisional; Region: PRK06547 1303024008215 beta-galactosidase; Region: BGL; TIGR03356 1303024008216 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1303024008217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008218 elongation factor Ts; Provisional; Region: tsf; PRK09377 1303024008219 UBA/TS-N domain; Region: UBA; pfam00627 1303024008220 Elongation factor TS; Region: EF_TS; pfam00889 1303024008221 Elongation factor TS; Region: EF_TS; pfam00889 1303024008222 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1303024008223 rRNA interaction site [nucleotide binding]; other site 1303024008224 S8 interaction site; other site 1303024008225 putative laminin-1 binding site; other site 1303024008226 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1303024008227 Peptidase family M23; Region: Peptidase_M23; pfam01551 1303024008228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008230 Predicted transcriptional regulators [Transcription]; Region: COG1733 1303024008231 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1303024008232 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024008233 Transport protein; Region: actII; TIGR00833 1303024008234 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1303024008235 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024008236 active site 1303024008237 DNA binding site [nucleotide binding] 1303024008238 Int/Topo IB signature motif; other site 1303024008239 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1303024008240 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1303024008241 FAD binding pocket [chemical binding]; other site 1303024008242 FAD binding motif [chemical binding]; other site 1303024008243 phosphate binding motif [ion binding]; other site 1303024008244 NAD binding pocket [chemical binding]; other site 1303024008245 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1303024008246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008247 DoxX-like family; Region: DoxX_2; pfam13564 1303024008248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024008249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024008250 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1303024008251 putative dimerization interface [polypeptide binding]; other site 1303024008252 Predicted membrane protein [Function unknown]; Region: COG3619 1303024008253 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1303024008254 active site clefts [active] 1303024008255 zinc binding site [ion binding]; other site 1303024008256 dimer interface [polypeptide binding]; other site 1303024008257 DNA protecting protein DprA; Region: dprA; TIGR00732 1303024008258 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1303024008259 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1303024008260 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1303024008261 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1303024008262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024008263 Walker A motif; other site 1303024008264 ATP binding site [chemical binding]; other site 1303024008265 Walker B motif; other site 1303024008266 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1303024008267 hypothetical protein; Reviewed; Region: PRK12497 1303024008268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008269 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1303024008270 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 1303024008271 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1303024008272 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1303024008273 RNA/DNA hybrid binding site [nucleotide binding]; other site 1303024008274 active site 1303024008275 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1303024008276 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1303024008277 Catalytic site [active] 1303024008278 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1303024008279 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1303024008280 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1303024008281 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1303024008282 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1303024008283 RimM N-terminal domain; Region: RimM; pfam01782 1303024008284 PRC-barrel domain; Region: PRC; pfam05239 1303024008285 hypothetical protein; Provisional; Region: PRK02821 1303024008286 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1303024008287 G-X-X-G motif; other site 1303024008288 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1303024008289 SnoaL-like domain; Region: SnoaL_4; pfam13577 1303024008290 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024008291 CoenzymeA binding site [chemical binding]; other site 1303024008292 subunit interaction site [polypeptide binding]; other site 1303024008293 PHB binding site; other site 1303024008294 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1303024008295 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1303024008296 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 1303024008297 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1303024008298 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1303024008299 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1303024008300 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1303024008301 active site 1303024008302 signal recognition particle protein; Provisional; Region: PRK10867 1303024008303 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1303024008304 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1303024008305 P loop; other site 1303024008306 GTP binding site [chemical binding]; other site 1303024008307 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1303024008308 PII uridylyl-transferase; Provisional; Region: PRK03381 1303024008309 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1303024008310 metal binding triad; other site 1303024008311 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1303024008312 HD domain; Region: HD; pfam01966 1303024008313 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1303024008314 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1303024008315 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1303024008316 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1303024008317 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1303024008318 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1303024008319 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1303024008320 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1303024008321 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1303024008322 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1303024008323 homotetramer interface [polypeptide binding]; other site 1303024008324 FMN binding site [chemical binding]; other site 1303024008325 homodimer contacts [polypeptide binding]; other site 1303024008326 putative active site [active] 1303024008327 putative substrate binding site [chemical binding]; other site 1303024008328 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1303024008329 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1303024008330 catalytic residues [active] 1303024008331 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1303024008332 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1303024008333 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1303024008334 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1303024008335 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1303024008336 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1303024008337 Walker A/P-loop; other site 1303024008338 ATP binding site [chemical binding]; other site 1303024008339 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1303024008340 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1303024008341 ABC transporter signature motif; other site 1303024008342 Walker B; other site 1303024008343 D-loop; other site 1303024008344 H-loop/switch region; other site 1303024008345 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1303024008346 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1303024008347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024008348 active site 1303024008349 phosphorylation site [posttranslational modification] 1303024008350 intermolecular recognition site; other site 1303024008351 dimerization interface [polypeptide binding]; other site 1303024008352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024008353 DNA binding site [nucleotide binding] 1303024008354 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1303024008355 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1303024008356 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1303024008357 Ligand Binding Site [chemical binding]; other site 1303024008358 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1303024008359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024008360 phosphorylation site [posttranslational modification] 1303024008361 dimer interface [polypeptide binding]; other site 1303024008362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024008363 ATP binding site [chemical binding]; other site 1303024008364 Mg2+ binding site [ion binding]; other site 1303024008365 G-X-G motif; other site 1303024008366 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1303024008367 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1303024008368 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1303024008369 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1303024008370 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1303024008371 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1303024008372 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1303024008373 DNA binding site [nucleotide binding] 1303024008374 catalytic residue [active] 1303024008375 H2TH interface [polypeptide binding]; other site 1303024008376 putative catalytic residues [active] 1303024008377 turnover-facilitating residue; other site 1303024008378 intercalation triad [nucleotide binding]; other site 1303024008379 8OG recognition residue [nucleotide binding]; other site 1303024008380 putative reading head residues; other site 1303024008381 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1303024008382 ribonuclease III; Reviewed; Region: rnc; PRK00102 1303024008383 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1303024008384 dimerization interface [polypeptide binding]; other site 1303024008385 active site 1303024008386 metal binding site [ion binding]; metal-binding site 1303024008387 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1303024008388 dsRNA binding site [nucleotide binding]; other site 1303024008389 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1303024008390 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1303024008391 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1303024008392 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1303024008393 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1303024008394 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1303024008395 active site 1303024008396 (T/H)XGH motif; other site 1303024008397 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1303024008398 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1303024008399 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1303024008400 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1303024008401 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1303024008402 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024008403 aldehyde oxidase; Region: mam_aldehyde_ox; TIGR02969 1303024008404 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1303024008405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024008406 S-adenosylmethionine binding site [chemical binding]; other site 1303024008407 pyruvate carboxylase; Reviewed; Region: PRK12999 1303024008408 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1303024008409 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1303024008410 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1303024008411 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1303024008412 active site 1303024008413 catalytic residues [active] 1303024008414 metal binding site [ion binding]; metal-binding site 1303024008415 homodimer binding site [polypeptide binding]; other site 1303024008416 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1303024008417 carboxyltransferase (CT) interaction site; other site 1303024008418 biotinylation site [posttranslational modification]; other site 1303024008419 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1303024008420 putative active site [active] 1303024008421 redox center [active] 1303024008422 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1303024008423 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1303024008424 catalytic residues [active] 1303024008425 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024008426 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1303024008427 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024008428 Cutinase; Region: Cutinase; pfam01083 1303024008429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008431 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1303024008432 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1303024008433 Cytochrome P450; Region: p450; cl12078 1303024008434 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024008435 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1303024008436 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1303024008437 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1303024008438 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1303024008439 generic binding surface II; other site 1303024008440 ssDNA binding site; other site 1303024008441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024008442 ATP binding site [chemical binding]; other site 1303024008443 putative Mg++ binding site [ion binding]; other site 1303024008444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024008445 nucleotide binding region [chemical binding]; other site 1303024008446 ATP-binding site [chemical binding]; other site 1303024008447 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1303024008448 DAK2 domain; Region: Dak2; pfam02734 1303024008449 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1303024008450 enoyl-CoA hydratase; Provisional; Region: PRK06688 1303024008451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024008452 substrate binding site [chemical binding]; other site 1303024008453 oxyanion hole (OAH) forming residues; other site 1303024008454 trimer interface [polypeptide binding]; other site 1303024008455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1303024008456 Secretory lipase; Region: LIP; pfam03583 1303024008457 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1303024008458 ligand binding site [chemical binding]; other site 1303024008459 active site 1303024008460 UGI interface [polypeptide binding]; other site 1303024008461 catalytic site [active] 1303024008462 thiamine monophosphate kinase; Provisional; Region: PRK05731 1303024008463 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1303024008464 ATP binding site [chemical binding]; other site 1303024008465 dimerization interface [polypeptide binding]; other site 1303024008466 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1303024008467 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1303024008468 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1303024008469 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1303024008470 cystathionine gamma-lyase; Validated; Region: PRK07582 1303024008471 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1303024008472 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024008473 catalytic residue [active] 1303024008474 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1303024008475 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1303024008476 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1303024008477 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1303024008478 polyphosphate kinase; Provisional; Region: PRK05443 1303024008479 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1303024008480 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1303024008481 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1303024008482 putative domain interface [polypeptide binding]; other site 1303024008483 putative active site [active] 1303024008484 catalytic site [active] 1303024008485 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1303024008486 putative domain interface [polypeptide binding]; other site 1303024008487 putative active site [active] 1303024008488 catalytic site [active] 1303024008489 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1303024008490 active site 1303024008491 Ap6A binding site [chemical binding]; other site 1303024008492 nudix motif; other site 1303024008493 metal binding site [ion binding]; metal-binding site 1303024008494 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024008495 catalytic core [active] 1303024008496 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1303024008497 IHF - DNA interface [nucleotide binding]; other site 1303024008498 IHF dimer interface [polypeptide binding]; other site 1303024008499 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1303024008500 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1303024008501 substrate binding site [chemical binding]; other site 1303024008502 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1303024008503 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1303024008504 substrate binding site [chemical binding]; other site 1303024008505 ligand binding site [chemical binding]; other site 1303024008506 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1303024008507 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1303024008508 Bacterial transcriptional regulator; Region: IclR; pfam01614 1303024008509 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1303024008510 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1303024008511 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1303024008512 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1303024008513 HIGH motif; other site 1303024008514 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1303024008515 active site 1303024008516 KMSKS motif; other site 1303024008517 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1303024008518 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1303024008519 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1303024008520 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1303024008521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024008522 putative substrate translocation pore; other site 1303024008523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024008524 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1303024008525 tartrate dehydrogenase; Region: TTC; TIGR02089 1303024008526 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1303024008527 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1303024008528 ligand binding site [chemical binding]; other site 1303024008529 NAD binding site [chemical binding]; other site 1303024008530 dimerization interface [polypeptide binding]; other site 1303024008531 catalytic site [active] 1303024008532 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1303024008533 putative L-serine binding site [chemical binding]; other site 1303024008534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008536 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024008537 ABC1 family; Region: ABC1; pfam03109 1303024008538 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024008539 ABC1 family; Region: ABC1; pfam03109 1303024008540 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024008541 Cytochrome P450; Region: p450; cl12078 1303024008542 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024008543 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1303024008544 acyl-activating enzyme (AAE) consensus motif; other site 1303024008545 AMP binding site [chemical binding]; other site 1303024008546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024008547 Condensation domain; Region: Condensation; pfam00668 1303024008548 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1303024008549 Condensation domain; Region: Condensation; pfam00668 1303024008550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024008551 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1303024008552 acyl-activating enzyme (AAE) consensus motif; other site 1303024008553 AMP binding site [chemical binding]; other site 1303024008554 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024008555 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1303024008556 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1303024008557 putative NAD(P) binding site [chemical binding]; other site 1303024008558 active site 1303024008559 putative substrate binding site [chemical binding]; other site 1303024008560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024008561 dimerization interface [polypeptide binding]; other site 1303024008562 putative DNA binding site [nucleotide binding]; other site 1303024008563 putative Zn2+ binding site [ion binding]; other site 1303024008564 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1303024008565 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1303024008566 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1303024008567 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1303024008568 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1303024008569 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1303024008570 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1303024008571 putative valine binding site [chemical binding]; other site 1303024008572 dimer interface [polypeptide binding]; other site 1303024008573 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1303024008574 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1303024008575 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1303024008576 PYR/PP interface [polypeptide binding]; other site 1303024008577 dimer interface [polypeptide binding]; other site 1303024008578 TPP binding site [chemical binding]; other site 1303024008579 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1303024008580 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1303024008581 TPP-binding site [chemical binding]; other site 1303024008582 dimer interface [polypeptide binding]; other site 1303024008583 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1303024008584 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1303024008585 hypothetical protein; Provisional; Region: PRK06541 1303024008586 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024008587 inhibitor-cofactor binding pocket; inhibition site 1303024008588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024008589 catalytic residue [active] 1303024008590 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1303024008591 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1303024008592 AsnC family; Region: AsnC_trans_reg; pfam01037 1303024008593 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1303024008594 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1303024008595 NAD(P) binding site [chemical binding]; other site 1303024008596 catalytic residues [active] 1303024008597 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024008598 MarR family; Region: MarR_2; cl17246 1303024008599 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024008600 FAD binding domain; Region: FAD_binding_3; pfam01494 1303024008601 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1303024008602 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1303024008603 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1303024008604 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1303024008605 GatB domain; Region: GatB_Yqey; smart00845 1303024008606 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024008607 6-phosphofructokinase; Provisional; Region: PRK03202 1303024008608 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1303024008609 active site 1303024008610 ADP/pyrophosphate binding site [chemical binding]; other site 1303024008611 dimerization interface [polypeptide binding]; other site 1303024008612 allosteric effector site; other site 1303024008613 fructose-1,6-bisphosphate binding site; other site 1303024008614 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1303024008615 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024008616 substrate binding pocket [chemical binding]; other site 1303024008617 catalytic triad [active] 1303024008618 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024008619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024008620 active site 1303024008621 phosphorylation site [posttranslational modification] 1303024008622 intermolecular recognition site; other site 1303024008623 dimerization interface [polypeptide binding]; other site 1303024008624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024008625 DNA binding site [nucleotide binding] 1303024008626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024008627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1303024008628 dimerization interface [polypeptide binding]; other site 1303024008629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024008630 dimer interface [polypeptide binding]; other site 1303024008631 phosphorylation site [posttranslational modification] 1303024008632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024008633 ATP binding site [chemical binding]; other site 1303024008634 Mg2+ binding site [ion binding]; other site 1303024008635 G-X-G motif; other site 1303024008636 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1303024008637 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1303024008638 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1303024008639 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1303024008640 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1303024008641 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1303024008642 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1303024008643 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1303024008644 nucleotide binding pocket [chemical binding]; other site 1303024008645 K-X-D-G motif; other site 1303024008646 catalytic site [active] 1303024008647 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1303024008648 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1303024008649 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1303024008650 Dimer interface [polypeptide binding]; other site 1303024008651 BRCT sequence motif; other site 1303024008652 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1303024008653 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1303024008654 enoyl-CoA hydratase; Provisional; Region: PRK06142 1303024008655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024008656 substrate binding site [chemical binding]; other site 1303024008657 oxyanion hole (OAH) forming residues; other site 1303024008658 trimer interface [polypeptide binding]; other site 1303024008659 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1303024008660 putative FMN binding site [chemical binding]; other site 1303024008661 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1303024008662 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1303024008663 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1303024008664 homodimer interface [polypeptide binding]; other site 1303024008665 putative substrate binding pocket [chemical binding]; other site 1303024008666 diiron center [ion binding]; other site 1303024008667 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1303024008668 active site 1303024008669 catalytic triad [active] 1303024008670 oxyanion hole [active] 1303024008671 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1303024008672 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1303024008673 Ligand Binding Site [chemical binding]; other site 1303024008674 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1303024008675 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1303024008676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024008677 catalytic residue [active] 1303024008678 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1303024008679 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1303024008680 putative acyl-acceptor binding pocket; other site 1303024008681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1303024008682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024008683 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1303024008684 NAD(P) binding site [chemical binding]; other site 1303024008685 active site 1303024008686 AAA ATPase domain; Region: AAA_16; pfam13191 1303024008687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024008688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024008689 DNA binding residues [nucleotide binding] 1303024008690 dimerization interface [polypeptide binding]; other site 1303024008691 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1303024008692 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1303024008693 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1303024008694 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1303024008695 Ligand binding site [chemical binding]; other site 1303024008696 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1303024008697 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024008698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024008699 S-adenosylmethionine binding site [chemical binding]; other site 1303024008700 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1303024008701 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1303024008702 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1303024008703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024008704 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1303024008705 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1303024008706 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024008707 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024008708 acyl-activating enzyme (AAE) consensus motif; other site 1303024008709 acyl-activating enzyme (AAE) consensus motif; other site 1303024008710 AMP binding site [chemical binding]; other site 1303024008711 active site 1303024008712 CoA binding site [chemical binding]; other site 1303024008713 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1303024008714 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1303024008715 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1303024008716 putative NAD(P) binding site [chemical binding]; other site 1303024008717 active site 1303024008718 putative substrate binding site [chemical binding]; other site 1303024008719 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1303024008720 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024008721 putative DNA binding site [nucleotide binding]; other site 1303024008722 putative Zn2+ binding site [ion binding]; other site 1303024008723 AsnC family; Region: AsnC_trans_reg; pfam01037 1303024008724 AzlC protein; Region: AzlC; cl00570 1303024008725 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1303024008726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008728 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024008729 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024008730 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024008731 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024008732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024008733 dimerization interface [polypeptide binding]; other site 1303024008734 putative DNA binding site [nucleotide binding]; other site 1303024008735 putative Zn2+ binding site [ion binding]; other site 1303024008736 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024008737 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1303024008738 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1303024008739 trimer interface [polypeptide binding]; other site 1303024008740 active site 1303024008741 substrate binding site [chemical binding]; other site 1303024008742 CoA binding site [chemical binding]; other site 1303024008743 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1303024008744 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1303024008745 Trp docking motif [polypeptide binding]; other site 1303024008746 active site 1303024008747 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024008748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024008749 S-adenosylmethionine binding site [chemical binding]; other site 1303024008750 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1303024008751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024008752 substrate binding site [chemical binding]; other site 1303024008753 oxyanion hole (OAH) forming residues; other site 1303024008754 trimer interface [polypeptide binding]; other site 1303024008755 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1303024008756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024008757 Walker A/P-loop; other site 1303024008758 ATP binding site [chemical binding]; other site 1303024008759 Q-loop/lid; other site 1303024008760 ABC transporter signature motif; other site 1303024008761 Walker B; other site 1303024008762 D-loop; other site 1303024008763 H-loop/switch region; other site 1303024008764 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1303024008765 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024008766 Predicted membrane protein [Function unknown]; Region: COG2364 1303024008767 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1303024008768 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1303024008769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024008770 DNA-binding site [nucleotide binding]; DNA binding site 1303024008771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024008772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024008773 homodimer interface [polypeptide binding]; other site 1303024008774 catalytic residue [active] 1303024008775 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1303024008776 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1303024008777 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1303024008778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024008779 motif II; other site 1303024008780 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1303024008781 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1303024008782 D-pathway; other site 1303024008783 Putative ubiquinol binding site [chemical binding]; other site 1303024008784 Low-spin heme (heme b) binding site [chemical binding]; other site 1303024008785 Putative water exit pathway; other site 1303024008786 Binuclear center (heme o3/CuB) [ion binding]; other site 1303024008787 K-pathway; other site 1303024008788 Putative proton exit pathway; other site 1303024008789 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1303024008790 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1303024008791 siderophore binding site; other site 1303024008792 YCII-related domain; Region: YCII; cl00999 1303024008793 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024008794 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1303024008795 hydrophobic ligand binding site; other site 1303024008796 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1303024008797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008799 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1303024008800 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024008801 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1303024008802 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1303024008803 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1303024008804 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1303024008805 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1303024008806 putative NAD(P) binding site [chemical binding]; other site 1303024008807 putative substrate binding site [chemical binding]; other site 1303024008808 catalytic Zn binding site [ion binding]; other site 1303024008809 structural Zn binding site [ion binding]; other site 1303024008810 dimer interface [polypeptide binding]; other site 1303024008811 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1303024008812 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1303024008813 active site 1303024008814 non-prolyl cis peptide bond; other site 1303024008815 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1303024008816 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1303024008817 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1303024008818 dimer interface [polypeptide binding]; other site 1303024008819 putative radical transfer pathway; other site 1303024008820 diiron center [ion binding]; other site 1303024008821 tyrosyl radical; other site 1303024008822 short chain dehydrogenase; Provisional; Region: PRK07825 1303024008823 classical (c) SDRs; Region: SDR_c; cd05233 1303024008824 NAD(P) binding site [chemical binding]; other site 1303024008825 active site 1303024008826 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1303024008827 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1303024008828 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1303024008829 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024008830 SCP-2 sterol transfer family; Region: SCP2; cl01225 1303024008831 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1303024008832 dimerization interface [polypeptide binding]; other site 1303024008833 substrate binding pocket [chemical binding]; other site 1303024008834 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1303024008835 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024008836 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1303024008837 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1303024008838 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1303024008839 active site 1303024008840 dimer interface [polypeptide binding]; other site 1303024008841 catalytic residues [active] 1303024008842 effector binding site; other site 1303024008843 R2 peptide binding site; other site 1303024008844 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1303024008845 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1303024008846 catalytic residues [active] 1303024008847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024008848 putative substrate translocation pore; other site 1303024008849 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024008850 MULE transposase domain; Region: MULE; pfam10551 1303024008851 Predicted flavoprotein [General function prediction only]; Region: COG0431 1303024008852 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1303024008853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008855 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1303024008856 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1303024008857 homodimer interface [polypeptide binding]; other site 1303024008858 NAD binding pocket [chemical binding]; other site 1303024008859 ATP binding pocket [chemical binding]; other site 1303024008860 Mg binding site [ion binding]; other site 1303024008861 active-site loop [active] 1303024008862 short chain dehydrogenase; Provisional; Region: PRK07832 1303024008863 classical (c) SDRs; Region: SDR_c; cd05233 1303024008864 NAD(P) binding site [chemical binding]; other site 1303024008865 active site 1303024008866 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1303024008867 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1303024008868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008870 Cytochrome P450; Region: p450; cl12078 1303024008871 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024008872 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1303024008873 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1303024008874 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1303024008875 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1303024008876 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1303024008877 short chain dehydrogenase; Provisional; Region: PRK12744 1303024008878 NADP binding site [chemical binding]; other site 1303024008879 homodimer interface [polypeptide binding]; other site 1303024008880 active site 1303024008881 substrate binding site [chemical binding]; other site 1303024008882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024008883 NAD(P) binding site [chemical binding]; other site 1303024008884 active site 1303024008885 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1303024008886 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1303024008887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024008888 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024008889 DNA binding residues [nucleotide binding] 1303024008890 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1303024008891 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1303024008892 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1303024008893 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1303024008894 Putative zinc-finger; Region: zf-HC2; pfam13490 1303024008895 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 1303024008896 Isochorismatase family; Region: Isochorismatase; pfam00857 1303024008897 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1303024008898 catalytic triad [active] 1303024008899 conserved cis-peptide bond; other site 1303024008900 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1303024008901 Na binding site [ion binding]; other site 1303024008902 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1303024008903 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024008904 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1303024008905 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1303024008906 acyl-activating enzyme (AAE) consensus motif; other site 1303024008907 putative AMP binding site [chemical binding]; other site 1303024008908 putative active site [active] 1303024008909 acyl-activating enzyme (AAE) consensus motif; other site 1303024008910 putative CoA binding site [chemical binding]; other site 1303024008911 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1303024008912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024008913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024008914 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1303024008915 short chain dehydrogenase; Provisional; Region: PRK06197 1303024008916 putative NAD(P) binding site [chemical binding]; other site 1303024008917 active site 1303024008918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024008919 NAD(P) binding site [chemical binding]; other site 1303024008920 active site 1303024008921 NAD-dependent deacetylase; Provisional; Region: PRK00481 1303024008922 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1303024008923 NAD+ binding site [chemical binding]; other site 1303024008924 substrate binding site [chemical binding]; other site 1303024008925 Zn binding site [ion binding]; other site 1303024008926 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 1303024008927 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1303024008928 Transcription factor WhiB; Region: Whib; pfam02467 1303024008929 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024008930 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1303024008931 AIPR protein; Region: AIPR; pfam10592 1303024008932 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1303024008933 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1303024008934 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024008935 active site 1303024008936 DNA binding site [nucleotide binding] 1303024008937 Int/Topo IB signature motif; other site 1303024008938 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1303024008939 Peptidase M76 family; Region: Peptidase_M76; pfam09768 1303024008940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024008941 non-specific DNA binding site [nucleotide binding]; other site 1303024008942 salt bridge; other site 1303024008943 sequence-specific DNA binding site [nucleotide binding]; other site 1303024008944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024008945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024008946 non-specific DNA binding site [nucleotide binding]; other site 1303024008947 salt bridge; other site 1303024008948 sequence-specific DNA binding site [nucleotide binding]; other site 1303024008949 Helix-turn-helix domain; Region: HTH_17; pfam12728 1303024008950 AroM protein; Region: AroM; cl17601 1303024008951 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1303024008952 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1303024008953 hypothetical protein; Reviewed; Region: PRK09588 1303024008954 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1303024008955 polymerase nucleotide-binding site; other site 1303024008956 DNA-binding residues [nucleotide binding]; DNA binding site 1303024008957 nucleotide binding site [chemical binding]; other site 1303024008958 primase nucleotide-binding site [nucleotide binding]; other site 1303024008959 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 1303024008960 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 1303024008961 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 1303024008962 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1303024008963 active site 1303024008964 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1303024008965 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1303024008966 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1303024008967 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1303024008968 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1303024008969 amidase catalytic site [active] 1303024008970 Zn binding residues [ion binding]; other site 1303024008971 substrate binding site [chemical binding]; other site 1303024008972 Domain of unknown function (DUF955); Region: DUF955; cl01076 1303024008973 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 1303024008974 active site 1303024008975 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1303024008976 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1303024008977 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1303024008978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024008979 putative substrate translocation pore; other site 1303024008980 phosphoglucomutase; Validated; Region: PRK07564 1303024008981 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1303024008982 active site 1303024008983 substrate binding site [chemical binding]; other site 1303024008984 metal binding site [ion binding]; metal-binding site 1303024008985 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1303024008986 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1303024008987 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024008988 substrate binding pocket [chemical binding]; other site 1303024008989 catalytic triad [active] 1303024008990 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1303024008991 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024008992 substrate binding pocket [chemical binding]; other site 1303024008993 catalytic triad [active] 1303024008994 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1303024008995 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1303024008996 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1303024008997 dimer interface [polypeptide binding]; other site 1303024008998 active site 1303024008999 Predicted transcriptional regulators [Transcription]; Region: COG1733 1303024009000 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1303024009001 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1303024009002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024009003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024009004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1303024009005 dimerization interface [polypeptide binding]; other site 1303024009006 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1303024009007 nucleoside/Zn binding site; other site 1303024009008 dimer interface [polypeptide binding]; other site 1303024009009 catalytic motif [active] 1303024009010 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1303024009011 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1303024009012 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024009013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024009014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009015 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1303024009016 S-adenosylmethionine binding site [chemical binding]; other site 1303024009017 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1303024009018 anti sigma factor interaction site; other site 1303024009019 regulatory phosphorylation site [posttranslational modification]; other site 1303024009020 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1303024009021 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1303024009022 putative dimer interface [polypeptide binding]; other site 1303024009023 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1303024009024 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1303024009025 DNA binding residues [nucleotide binding] 1303024009026 putative dimer interface [polypeptide binding]; other site 1303024009027 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1303024009028 nudix motif; other site 1303024009029 acetolactate synthase; Reviewed; Region: PRK08322 1303024009030 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1303024009031 PYR/PP interface [polypeptide binding]; other site 1303024009032 dimer interface [polypeptide binding]; other site 1303024009033 TPP binding site [chemical binding]; other site 1303024009034 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1303024009035 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1303024009036 TPP-binding site [chemical binding]; other site 1303024009037 dimer interface [polypeptide binding]; other site 1303024009038 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024009039 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1303024009040 NAD(P) binding site [chemical binding]; other site 1303024009041 catalytic residues [active] 1303024009042 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1303024009043 SmpB-tmRNA interface; other site 1303024009044 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1303024009045 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1303024009046 FtsX-like permease family; Region: FtsX; pfam02687 1303024009047 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1303024009048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024009049 Walker A/P-loop; other site 1303024009050 ATP binding site [chemical binding]; other site 1303024009051 Q-loop/lid; other site 1303024009052 ABC transporter signature motif; other site 1303024009053 Walker B; other site 1303024009054 D-loop; other site 1303024009055 H-loop/switch region; other site 1303024009056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1303024009057 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1303024009058 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1303024009059 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1303024009060 RF-1 domain; Region: RF-1; pfam00472 1303024009061 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1303024009062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024009063 putative DNA binding site [nucleotide binding]; other site 1303024009064 putative Zn2+ binding site [ion binding]; other site 1303024009065 Bacterial transcriptional regulator; Region: IclR; pfam01614 1303024009066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024009067 active site 1303024009068 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024009069 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1303024009070 active site 1303024009071 ferredoxin-NADP+ reductase; Region: PLN02852 1303024009072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024009073 hypothetical protein; Provisional; Region: PRK06834 1303024009074 hypothetical protein; Provisional; Region: PRK07236 1303024009075 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024009076 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1303024009077 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1303024009078 active site 1303024009079 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024009080 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024009081 active site 1303024009082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024009083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024009084 active site 1303024009085 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024009086 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc; pfam03364 1303024009087 acyl-CoA synthetase; Validated; Region: PRK07788 1303024009088 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024009089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024009090 AMP binding site [chemical binding]; other site 1303024009091 active site 1303024009092 acyl-activating enzyme (AAE) consensus motif; other site 1303024009093 CoA binding site [chemical binding]; other site 1303024009094 Clp protease ATP binding subunit; Region: clpC; CHL00095 1303024009095 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024009096 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1303024009097 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 1303024009098 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1303024009099 hypothetical protein; Validated; Region: PRK00068 1303024009100 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1303024009101 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1303024009102 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1303024009103 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1303024009104 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1303024009105 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1303024009106 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024009107 ABC1 family; Region: ABC1; pfam03109 1303024009108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1303024009109 active site 1303024009110 ATP binding site [chemical binding]; other site 1303024009111 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024009112 ABC1 family; Region: ABC1; pfam03109 1303024009113 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1303024009114 active site 1303024009115 ATP binding site [chemical binding]; other site 1303024009116 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024009117 ABC1 family; Region: ABC1; pfam03109 1303024009118 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1303024009119 active site 1303024009120 ATP binding site [chemical binding]; other site 1303024009121 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1303024009122 activation loop (A-loop); other site 1303024009123 Transcription factor WhiB; Region: Whib; pfam02467 1303024009124 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1303024009125 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1303024009126 Part of AAA domain; Region: AAA_19; pfam13245 1303024009127 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1303024009128 Family description; Region: UvrD_C_2; pfam13538 1303024009129 HRDC domain; Region: HRDC; pfam00570 1303024009130 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1303024009131 catalytic residues [active] 1303024009132 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1303024009133 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1303024009134 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1303024009135 putative NADH binding site [chemical binding]; other site 1303024009136 putative active site [active] 1303024009137 nudix motif; other site 1303024009138 putative metal binding site [ion binding]; other site 1303024009139 Ion channel; Region: Ion_trans_2; pfam07885 1303024009140 TrkA-N domain; Region: TrkA_N; pfam02254 1303024009141 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1303024009142 Part of AAA domain; Region: AAA_19; pfam13245 1303024009143 Family description; Region: UvrD_C_2; pfam13538 1303024009144 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1303024009145 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1303024009146 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1303024009147 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024009148 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1303024009149 catalytic site [active] 1303024009150 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1303024009151 active site 1303024009152 DNA binding site [nucleotide binding] 1303024009153 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1303024009154 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1303024009155 putative active site [active] 1303024009156 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1303024009157 putative active site [active] 1303024009158 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1303024009159 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1303024009160 active site 1303024009161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024009162 DNA binding site [nucleotide binding] 1303024009163 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1303024009164 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1303024009165 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1303024009166 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1303024009167 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1303024009168 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1303024009169 TIGR02569 family protein; Region: TIGR02569_actnb 1303024009170 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1303024009171 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1303024009172 ATP binding site [chemical binding]; other site 1303024009173 substrate interface [chemical binding]; other site 1303024009174 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1303024009175 active site residue [active] 1303024009176 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1303024009177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024009178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009179 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1303024009180 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024009181 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1303024009182 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1303024009183 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1303024009184 ATP binding site [chemical binding]; other site 1303024009185 Mg++ binding site [ion binding]; other site 1303024009186 motif III; other site 1303024009187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024009188 nucleotide binding region [chemical binding]; other site 1303024009189 ATP-binding site [chemical binding]; other site 1303024009190 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1303024009191 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1303024009192 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024009193 P-loop; other site 1303024009194 Magnesium ion binding site [ion binding]; other site 1303024009195 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024009196 Magnesium ion binding site [ion binding]; other site 1303024009197 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024009198 catalytic core [active] 1303024009199 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1303024009200 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1303024009201 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1303024009202 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1303024009203 Transcription factor WhiB; Region: Whib; pfam02467 1303024009204 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1303024009205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1303024009206 Histidine kinase; Region: HisKA_2; pfam07568 1303024009207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024009208 ATP binding site [chemical binding]; other site 1303024009209 Mg2+ binding site [ion binding]; other site 1303024009210 G-X-G motif; other site 1303024009211 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1303024009212 carboxyltransferase (CT) interaction site; other site 1303024009213 biotinylation site [posttranslational modification]; other site 1303024009214 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1303024009215 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1303024009216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024009217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024009218 DNA binding residues [nucleotide binding] 1303024009219 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1303024009220 putative deacylase active site [active] 1303024009221 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1303024009222 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1303024009223 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1303024009224 hinge; other site 1303024009225 active site 1303024009226 Predicted GTPases [General function prediction only]; Region: COG1162 1303024009227 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1303024009228 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1303024009229 GTP/Mg2+ binding site [chemical binding]; other site 1303024009230 G4 box; other site 1303024009231 G5 box; other site 1303024009232 G1 box; other site 1303024009233 Switch I region; other site 1303024009234 G2 box; other site 1303024009235 G3 box; other site 1303024009236 Switch II region; other site 1303024009237 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1303024009238 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1303024009239 putative di-iron ligands [ion binding]; other site 1303024009240 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1303024009241 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1303024009242 FAD binding pocket [chemical binding]; other site 1303024009243 FAD binding motif [chemical binding]; other site 1303024009244 phosphate binding motif [ion binding]; other site 1303024009245 beta-alpha-beta structure motif; other site 1303024009246 NAD binding pocket [chemical binding]; other site 1303024009247 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024009248 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1303024009249 catalytic loop [active] 1303024009250 iron binding site [ion binding]; other site 1303024009251 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1303024009252 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1303024009253 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1303024009254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024009255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024009256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009257 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1303024009258 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1303024009259 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024009260 CoenzymeA binding site [chemical binding]; other site 1303024009261 subunit interaction site [polypeptide binding]; other site 1303024009262 PHB binding site; other site 1303024009263 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1303024009264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024009265 DNA-binding site [nucleotide binding]; DNA binding site 1303024009266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024009267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024009268 homodimer interface [polypeptide binding]; other site 1303024009269 catalytic residue [active] 1303024009270 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1303024009271 30S subunit binding site; other site 1303024009272 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1303024009273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024009274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024009276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024009277 active site 1303024009278 lipoprotein LpqB; Provisional; Region: PRK13616 1303024009279 Sporulation and spore germination; Region: Germane; pfam10646 1303024009280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024009281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1303024009282 dimerization interface [polypeptide binding]; other site 1303024009283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024009284 dimer interface [polypeptide binding]; other site 1303024009285 phosphorylation site [posttranslational modification] 1303024009286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024009287 ATP binding site [chemical binding]; other site 1303024009288 Mg2+ binding site [ion binding]; other site 1303024009289 G-X-G motif; other site 1303024009290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024009291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024009292 active site 1303024009293 phosphorylation site [posttranslational modification] 1303024009294 intermolecular recognition site; other site 1303024009295 dimerization interface [polypeptide binding]; other site 1303024009296 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024009297 DNA binding site [nucleotide binding] 1303024009298 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024009299 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1303024009300 acyl-activating enzyme (AAE) consensus motif; other site 1303024009301 AMP binding site [chemical binding]; other site 1303024009302 active site 1303024009303 CoA binding site [chemical binding]; other site 1303024009304 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1303024009305 MgtC family; Region: MgtC; pfam02308 1303024009306 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1303024009307 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1303024009308 TMP-binding site; other site 1303024009309 ATP-binding site [chemical binding]; other site 1303024009310 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1303024009311 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1303024009312 Bacterial transcriptional regulator; Region: IclR; pfam01614 1303024009313 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1303024009314 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1303024009315 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1303024009316 homotetramer interface [polypeptide binding]; other site 1303024009317 ligand binding site [chemical binding]; other site 1303024009318 catalytic site [active] 1303024009319 NAD binding site [chemical binding]; other site 1303024009320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024009321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009322 Rubredoxin [Energy production and conversion]; Region: COG1773 1303024009323 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1303024009324 iron binding site [ion binding]; other site 1303024009325 Rubredoxin; Region: Rubredoxin; pfam00301 1303024009326 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1303024009327 iron binding site [ion binding]; other site 1303024009328 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1303024009329 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1303024009330 Di-iron ligands [ion binding]; other site 1303024009331 amino acid transporter; Region: 2A0306; TIGR00909 1303024009332 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1303024009333 Cation efflux family; Region: Cation_efflux; pfam01545 1303024009334 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1303024009335 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1303024009336 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1303024009337 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1303024009338 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1303024009339 active site 1303024009340 substrate binding site [chemical binding]; other site 1303024009341 metal binding site [ion binding]; metal-binding site 1303024009342 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1303024009343 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1303024009344 Transcription factor WhiB; Region: Whib; pfam02467 1303024009345 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1303024009346 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1303024009347 dimer interface [polypeptide binding]; other site 1303024009348 substrate binding site [chemical binding]; other site 1303024009349 phosphate binding site [ion binding]; other site 1303024009350 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1303024009351 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 1303024009352 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1303024009353 putative FMN binding site [chemical binding]; other site 1303024009354 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1303024009355 nudix motif; other site 1303024009356 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1303024009357 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1303024009358 active site 1303024009359 Substrate binding site; other site 1303024009360 Mg++ binding site; other site 1303024009361 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1303024009362 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1303024009363 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1303024009364 Probable Catalytic site; other site 1303024009365 metal-binding site 1303024009366 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1303024009367 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1303024009368 NADP binding site [chemical binding]; other site 1303024009369 active site 1303024009370 putative substrate binding site [chemical binding]; other site 1303024009371 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1303024009372 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1303024009373 TIGR03089 family protein; Region: TIGR03089 1303024009374 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1303024009375 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1303024009376 putative active site [active] 1303024009377 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024009378 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1303024009379 FAD binding site [chemical binding]; other site 1303024009380 homotetramer interface [polypeptide binding]; other site 1303024009381 substrate binding pocket [chemical binding]; other site 1303024009382 catalytic base [active] 1303024009383 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1303024009384 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1303024009385 ATP-grasp domain; Region: ATP-grasp; pfam02222 1303024009386 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1303024009387 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1303024009388 active site 1303024009389 iron coordination sites [ion binding]; other site 1303024009390 substrate binding pocket [chemical binding]; other site 1303024009391 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1303024009392 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1303024009393 NADP binding site [chemical binding]; other site 1303024009394 dimer interface [polypeptide binding]; other site 1303024009395 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1303024009396 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1303024009397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024009398 Bacterial PH domain; Region: DUF304; pfam03703 1303024009399 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1303024009400 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1303024009401 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1303024009402 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1303024009403 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1303024009404 acyl-CoA synthetase; Provisional; Region: PRK13388 1303024009405 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024009406 acyl-activating enzyme (AAE) consensus motif; other site 1303024009407 AMP binding site [chemical binding]; other site 1303024009408 active site 1303024009409 CoA binding site [chemical binding]; other site 1303024009410 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1303024009411 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024009412 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1303024009413 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1303024009414 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1303024009415 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1303024009416 Maf-like protein; Region: Maf; pfam02545 1303024009417 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1303024009418 active site 1303024009419 dimer interface [polypeptide binding]; other site 1303024009420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024009421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009422 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1303024009423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024009424 S-adenosylmethionine binding site [chemical binding]; other site 1303024009425 GntP family permease; Region: GntP_permease; pfam02447 1303024009426 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1303024009427 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1303024009428 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024009429 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024009430 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1303024009431 active site 1303024009432 Phosphotransferase enzyme family; Region: APH; pfam01636 1303024009433 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1303024009434 putative active site [active] 1303024009435 ATP binding site [chemical binding]; other site 1303024009436 putative substrate binding site [chemical binding]; other site 1303024009437 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1303024009438 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024009439 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1303024009440 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1303024009441 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1303024009442 active site residue [active] 1303024009443 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1303024009444 active site residue [active] 1303024009445 Fe-S metabolism associated domain; Region: SufE; cl00951 1303024009446 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1303024009447 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1303024009448 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1303024009449 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1303024009450 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1303024009451 carboxyltransferase (CT) interaction site; other site 1303024009452 biotinylation site [posttranslational modification]; other site 1303024009453 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024009454 Predicted flavoprotein [General function prediction only]; Region: COG0431 1303024009455 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1303024009456 L-lysine aminotransferase; Provisional; Region: PRK08297 1303024009457 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024009458 inhibitor-cofactor binding pocket; inhibition site 1303024009459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024009460 catalytic residue [active] 1303024009461 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1303024009462 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1303024009463 AsnC family; Region: AsnC_trans_reg; pfam01037 1303024009464 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1303024009465 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1303024009466 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024009467 tetrameric interface [polypeptide binding]; other site 1303024009468 NAD binding site [chemical binding]; other site 1303024009469 catalytic residues [active] 1303024009470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024009471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009472 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1303024009473 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1303024009474 ATP binding site [chemical binding]; other site 1303024009475 putative Mg++ binding site [ion binding]; other site 1303024009476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1303024009477 nucleotide binding region [chemical binding]; other site 1303024009478 ATP-binding site [chemical binding]; other site 1303024009479 DEAD/H associated; Region: DEAD_assoc; pfam08494 1303024009480 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1303024009481 dimer interface [polypeptide binding]; other site 1303024009482 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024009483 metal binding site [ion binding]; metal-binding site 1303024009484 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1303024009485 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1303024009486 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1303024009487 active site 1303024009488 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1303024009489 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1303024009490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024009491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024009492 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1303024009493 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1303024009494 putative active site pocket [active] 1303024009495 dimerization interface [polypeptide binding]; other site 1303024009496 putative catalytic residue [active] 1303024009497 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1303024009498 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1303024009499 metal binding site [ion binding]; metal-binding site 1303024009500 putative dimer interface [polypeptide binding]; other site 1303024009501 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1303024009502 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1303024009503 metal binding site [ion binding]; metal-binding site 1303024009504 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1303024009505 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1303024009506 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1303024009507 active site 1303024009508 substrate binding site [chemical binding]; other site 1303024009509 metal binding site [ion binding]; metal-binding site 1303024009510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1303024009511 active site 1303024009512 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1303024009513 NlpC/P60 family; Region: NLPC_P60; pfam00877 1303024009514 adenosine deaminase; Provisional; Region: PRK09358 1303024009515 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1303024009516 active site 1303024009517 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1303024009518 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1303024009519 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1303024009520 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1303024009521 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1303024009522 active site 1303024009523 catalytic motif [active] 1303024009524 Zn binding site [ion binding]; other site 1303024009525 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024009526 MULE transposase domain; Region: MULE; pfam10551 1303024009527 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1303024009528 putative Iron-sulfur protein interface [polypeptide binding]; other site 1303024009529 putative proximal heme binding site [chemical binding]; other site 1303024009530 putative SdhD-like interface [polypeptide binding]; other site 1303024009531 putative distal heme binding site [chemical binding]; other site 1303024009532 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1303024009533 putative Iron-sulfur protein interface [polypeptide binding]; other site 1303024009534 putative proximal heme binding site [chemical binding]; other site 1303024009535 putative SdhC-like subunit interface [polypeptide binding]; other site 1303024009536 putative distal heme binding site [chemical binding]; other site 1303024009537 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1303024009538 L-aspartate oxidase; Provisional; Region: PRK06175 1303024009539 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1303024009540 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1303024009541 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1303024009542 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1303024009543 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1303024009544 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1303024009545 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024009546 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1303024009547 SnoaL-like domain; Region: SnoaL_2; pfam12680 1303024009548 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1303024009549 Strictosidine synthase; Region: Str_synth; pfam03088 1303024009550 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1303024009551 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1303024009552 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1303024009553 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1303024009554 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1303024009555 active site 1303024009556 HIGH motif; other site 1303024009557 dimer interface [polypeptide binding]; other site 1303024009558 KMSKS motif; other site 1303024009559 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1303024009560 putative active site [active] 1303024009561 putative catalytic site [active] 1303024009562 putative DNA binding site [nucleotide binding]; other site 1303024009563 putative phosphate binding site [ion binding]; other site 1303024009564 metal binding site A [ion binding]; metal-binding site 1303024009565 putative AP binding site [nucleotide binding]; other site 1303024009566 putative metal binding site B [ion binding]; other site 1303024009567 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024009568 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1303024009569 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1303024009570 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1303024009571 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1303024009572 homodimer interface [polypeptide binding]; other site 1303024009573 substrate-cofactor binding pocket; other site 1303024009574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024009575 catalytic residue [active] 1303024009576 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1303024009577 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1303024009578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024009579 S-adenosylmethionine binding site [chemical binding]; other site 1303024009580 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1303024009581 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1303024009582 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1303024009583 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1303024009584 homodimer interface [polypeptide binding]; other site 1303024009585 NADP binding site [chemical binding]; other site 1303024009586 substrate binding site [chemical binding]; other site 1303024009587 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1303024009588 FMN binding site [chemical binding]; other site 1303024009589 dimer interface [polypeptide binding]; other site 1303024009590 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1303024009591 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1303024009592 active site 1303024009593 FMN binding site [chemical binding]; other site 1303024009594 substrate binding site [chemical binding]; other site 1303024009595 putative catalytic residue [active] 1303024009596 Predicted transcriptional regulators [Transcription]; Region: COG1733 1303024009597 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1303024009598 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1303024009599 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1303024009600 NAD binding site [chemical binding]; other site 1303024009601 substrate binding site [chemical binding]; other site 1303024009602 putative active site [active] 1303024009603 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1303024009604 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1303024009605 phosphopeptide binding site; other site 1303024009606 YppG-like protein; Region: YppG; pfam14179 1303024009607 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1303024009608 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1303024009609 phosphopeptide binding site; other site 1303024009610 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1303024009611 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1303024009612 Walker A/P-loop; other site 1303024009613 ATP binding site [chemical binding]; other site 1303024009614 Q-loop/lid; other site 1303024009615 ABC transporter signature motif; other site 1303024009616 Walker B; other site 1303024009617 D-loop; other site 1303024009618 H-loop/switch region; other site 1303024009619 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1303024009620 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1303024009621 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1303024009622 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1303024009623 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1303024009624 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1303024009625 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1303024009626 active site 1303024009627 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1303024009628 generic binding surface II; other site 1303024009629 generic binding surface I; other site 1303024009630 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1303024009631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024009632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009633 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1303024009634 active site 1303024009635 NTP binding site [chemical binding]; other site 1303024009636 metal binding triad [ion binding]; metal-binding site 1303024009637 antibiotic binding site [chemical binding]; other site 1303024009638 Bacterial PH domain; Region: DUF304; cl01348 1303024009639 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1303024009640 short chain dehydrogenase; Provisional; Region: PRK07201 1303024009641 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1303024009642 putative NAD(P) binding site [chemical binding]; other site 1303024009643 active site 1303024009644 putative substrate binding site [chemical binding]; other site 1303024009645 classical (c) SDRs; Region: SDR_c; cd05233 1303024009646 NAD(P) binding site [chemical binding]; other site 1303024009647 active site 1303024009648 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1303024009649 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1303024009650 active site 1303024009651 DNA Polymerase Y-family; Region: PolY_like; cd03468 1303024009652 active site 1303024009653 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1303024009654 DNA binding site [nucleotide binding] 1303024009655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024009656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024009657 active site 1303024009658 phosphorylation site [posttranslational modification] 1303024009659 intermolecular recognition site; other site 1303024009660 dimerization interface [polypeptide binding]; other site 1303024009661 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024009662 DNA binding residues [nucleotide binding] 1303024009663 dimerization interface [polypeptide binding]; other site 1303024009664 PspC domain; Region: PspC; pfam04024 1303024009665 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1303024009666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024009667 ATP binding site [chemical binding]; other site 1303024009668 Mg2+ binding site [ion binding]; other site 1303024009669 G-X-G motif; other site 1303024009670 PspC domain; Region: PspC; pfam04024 1303024009671 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1303024009672 GMP synthase; Reviewed; Region: guaA; PRK00074 1303024009673 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1303024009674 AMP/PPi binding site [chemical binding]; other site 1303024009675 candidate oxyanion hole; other site 1303024009676 catalytic triad [active] 1303024009677 potential glutamine specificity residues [chemical binding]; other site 1303024009678 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1303024009679 ATP Binding subdomain [chemical binding]; other site 1303024009680 Ligand Binding sites [chemical binding]; other site 1303024009681 Dimerization subdomain; other site 1303024009682 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1303024009683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024009684 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1303024009685 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1303024009686 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1303024009687 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1303024009688 phosphate binding site [ion binding]; other site 1303024009689 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1303024009690 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1303024009691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1303024009692 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1303024009693 active site 1303024009694 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1303024009695 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1303024009696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024009697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024009698 DNA binding residues [nucleotide binding] 1303024009699 Transcription factor WhiB; Region: Whib; pfam02467 1303024009700 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1303024009701 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1303024009702 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1303024009703 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1303024009704 ring oligomerisation interface [polypeptide binding]; other site 1303024009705 ATP/Mg binding site [chemical binding]; other site 1303024009706 stacking interactions; other site 1303024009707 hinge regions; other site 1303024009708 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1303024009709 oligomerisation interface [polypeptide binding]; other site 1303024009710 mobile loop; other site 1303024009711 roof hairpin; other site 1303024009712 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1303024009713 UGMP family protein; Validated; Region: PRK09604 1303024009714 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1303024009715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024009716 Coenzyme A binding pocket [chemical binding]; other site 1303024009717 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1303024009718 Glycoprotease family; Region: Peptidase_M22; pfam00814 1303024009719 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1303024009720 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024009721 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024009722 alanine racemase; Reviewed; Region: alr; PRK00053 1303024009723 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1303024009724 active site 1303024009725 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1303024009726 dimer interface [polypeptide binding]; other site 1303024009727 substrate binding site [chemical binding]; other site 1303024009728 catalytic residues [active] 1303024009729 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1303024009730 L-tyrosine decarboxylase; Provisional; Region: PRK13520 1303024009731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024009732 catalytic residue [active] 1303024009733 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1303024009734 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1303024009735 putative substrate binding site [chemical binding]; other site 1303024009736 putative ATP binding site [chemical binding]; other site 1303024009737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024009738 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1303024009739 catalytic site [active] 1303024009740 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1303024009741 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1303024009742 glutaminase active site [active] 1303024009743 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1303024009744 dimer interface [polypeptide binding]; other site 1303024009745 active site 1303024009746 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1303024009747 dimer interface [polypeptide binding]; other site 1303024009748 active site 1303024009749 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1303024009750 cell division protein ZipA; Provisional; Region: PRK03427 1303024009751 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1303024009752 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1303024009753 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024009754 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1303024009755 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1303024009756 putative active site [active] 1303024009757 putative metal binding site [ion binding]; other site 1303024009758 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1303024009759 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1303024009760 active site 1303024009761 substrate binding site [chemical binding]; other site 1303024009762 metal binding site [ion binding]; metal-binding site 1303024009763 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1303024009764 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1303024009765 23S rRNA interface [nucleotide binding]; other site 1303024009766 L3 interface [polypeptide binding]; other site 1303024009767 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024009768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024009769 non-specific DNA binding site [nucleotide binding]; other site 1303024009770 salt bridge; other site 1303024009771 sequence-specific DNA binding site [nucleotide binding]; other site 1303024009772 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1303024009773 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1303024009774 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1303024009775 active site 1303024009776 ATP binding site [chemical binding]; other site 1303024009777 substrate binding site [chemical binding]; other site 1303024009778 activation loop (A-loop); other site 1303024009779 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1303024009780 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1303024009781 CGNR zinc finger; Region: zf-CGNR; pfam11706 1303024009782 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1303024009783 Cutinase; Region: Cutinase; pfam01083 1303024009784 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024009785 Cutinase; Region: Cutinase; pfam01083 1303024009786 Cutinase; Region: Cutinase; pfam01083 1303024009787 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1303024009788 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1303024009789 dimerization interface 3.5A [polypeptide binding]; other site 1303024009790 active site 1303024009791 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1303024009792 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1303024009793 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1303024009794 alphaNTD homodimer interface [polypeptide binding]; other site 1303024009795 alphaNTD - beta interaction site [polypeptide binding]; other site 1303024009796 alphaNTD - beta' interaction site [polypeptide binding]; other site 1303024009797 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1303024009798 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1303024009799 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1303024009800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1303024009801 RNA binding surface [nucleotide binding]; other site 1303024009802 30S ribosomal protein S11; Validated; Region: PRK05309 1303024009803 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1303024009804 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1303024009805 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1303024009806 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1303024009807 rRNA binding site [nucleotide binding]; other site 1303024009808 predicted 30S ribosome binding site; other site 1303024009809 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1303024009810 hypothetical protein; Provisional; Region: PRK07236 1303024009811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1303024009812 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1303024009813 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1303024009814 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1303024009815 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1303024009816 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1303024009817 NAD binding site [chemical binding]; other site 1303024009818 substrate binding site [chemical binding]; other site 1303024009819 homodimer interface [polypeptide binding]; other site 1303024009820 active site 1303024009821 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1303024009822 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1303024009823 Septum formation; Region: Septum_form; pfam13845 1303024009824 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1303024009825 active site 1303024009826 adenylate kinase; Reviewed; Region: adk; PRK00279 1303024009827 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1303024009828 AMP-binding site [chemical binding]; other site 1303024009829 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1303024009830 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1303024009831 SecY translocase; Region: SecY; pfam00344 1303024009832 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1303024009833 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024009834 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024009835 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1303024009836 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1303024009837 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1303024009838 tandem repeat interface [polypeptide binding]; other site 1303024009839 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1303024009840 oligomer interface [polypeptide binding]; other site 1303024009841 active site residues [active] 1303024009842 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1303024009843 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1303024009844 tandem repeat interface [polypeptide binding]; other site 1303024009845 oligomer interface [polypeptide binding]; other site 1303024009846 active site residues [active] 1303024009847 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024009848 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1303024009849 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1303024009850 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1303024009851 23S rRNA binding site [nucleotide binding]; other site 1303024009852 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1303024009853 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1303024009854 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1303024009855 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1303024009856 5S rRNA interface [nucleotide binding]; other site 1303024009857 L27 interface [polypeptide binding]; other site 1303024009858 23S rRNA interface [nucleotide binding]; other site 1303024009859 L5 interface [polypeptide binding]; other site 1303024009860 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1303024009861 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1303024009862 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1303024009863 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1303024009864 glutamate dehydrogenase; Provisional; Region: PRK09414 1303024009865 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1303024009866 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1303024009867 NAD(P) binding site [chemical binding]; other site 1303024009868 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1303024009869 [2Fe-2S] cluster binding site [ion binding]; other site 1303024009870 iron-sulfur cluster [ion binding]; other site 1303024009871 Carboxylesterase family; Region: COesterase; pfam00135 1303024009872 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1303024009873 substrate binding pocket [chemical binding]; other site 1303024009874 catalytic triad [active] 1303024009875 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1303024009876 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1303024009877 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1303024009878 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1303024009879 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1303024009880 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1303024009881 RNA binding site [nucleotide binding]; other site 1303024009882 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1303024009883 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1303024009884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024009885 putative substrate translocation pore; other site 1303024009886 Cutinase; Region: Cutinase; pfam01083 1303024009887 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1303024009888 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1303024009889 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024009890 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1303024009891 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1303024009892 putative translocon interaction site; other site 1303024009893 23S rRNA interface [nucleotide binding]; other site 1303024009894 signal recognition particle (SRP54) interaction site; other site 1303024009895 L23 interface [polypeptide binding]; other site 1303024009896 trigger factor interaction site; other site 1303024009897 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1303024009898 23S rRNA interface [nucleotide binding]; other site 1303024009899 5S rRNA interface [nucleotide binding]; other site 1303024009900 putative antibiotic binding site [chemical binding]; other site 1303024009901 L25 interface [polypeptide binding]; other site 1303024009902 L27 interface [polypeptide binding]; other site 1303024009903 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1303024009904 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1303024009905 G-X-X-G motif; other site 1303024009906 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1303024009907 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1303024009908 putative translocon binding site; other site 1303024009909 protein-rRNA interface [nucleotide binding]; other site 1303024009910 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1303024009911 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1303024009912 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1303024009913 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1303024009914 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1303024009915 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1303024009916 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1303024009917 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1303024009918 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1303024009919 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1303024009920 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1303024009921 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024009922 CoenzymeA binding site [chemical binding]; other site 1303024009923 subunit interaction site [polypeptide binding]; other site 1303024009924 PHB binding site; other site 1303024009925 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024009926 Cytochrome P450; Region: p450; cl12078 1303024009927 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1303024009928 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024009929 active site 1303024009930 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1303024009931 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1303024009932 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1303024009933 ethanolamine permease; Region: 2A0305; TIGR00908 1303024009934 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1303024009935 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1303024009936 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1303024009937 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1303024009938 Probable Catalytic site; other site 1303024009939 metal-binding site 1303024009940 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1303024009941 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1303024009942 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1303024009943 phosphate binding site [ion binding]; other site 1303024009944 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1303024009945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1303024009946 FeS/SAM binding site; other site 1303024009947 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1303024009948 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1303024009949 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1303024009950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024009951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1303024009952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024009953 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1303024009954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024009955 putative DNA binding site [nucleotide binding]; other site 1303024009956 putative Zn2+ binding site [ion binding]; other site 1303024009957 AsnC family; Region: AsnC_trans_reg; pfam01037 1303024009958 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1303024009959 Amidinotransferase; Region: Amidinotransf; pfam02274 1303024009960 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1303024009961 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024009962 inhibitor-cofactor binding pocket; inhibition site 1303024009963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024009964 catalytic residue [active] 1303024009965 amino acid transporter; Region: 2A0306; TIGR00909 1303024009966 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1303024009967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024009968 Ligand Binding Site [chemical binding]; other site 1303024009969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024009970 Ligand Binding Site [chemical binding]; other site 1303024009971 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1303024009972 classical (c) SDRs; Region: SDR_c; cd05233 1303024009973 NAD(P) binding site [chemical binding]; other site 1303024009974 active site 1303024009975 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1303024009976 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1303024009977 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1303024009978 elongation factor Tu; Reviewed; Region: PRK00049 1303024009979 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1303024009980 G1 box; other site 1303024009981 GEF interaction site [polypeptide binding]; other site 1303024009982 GTP/Mg2+ binding site [chemical binding]; other site 1303024009983 Switch I region; other site 1303024009984 G2 box; other site 1303024009985 G3 box; other site 1303024009986 Switch II region; other site 1303024009987 G4 box; other site 1303024009988 G5 box; other site 1303024009989 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1303024009990 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1303024009991 Antibiotic Binding Site [chemical binding]; other site 1303024009992 elongation factor G; Reviewed; Region: PRK00007 1303024009993 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1303024009994 G1 box; other site 1303024009995 putative GEF interaction site [polypeptide binding]; other site 1303024009996 GTP/Mg2+ binding site [chemical binding]; other site 1303024009997 Switch I region; other site 1303024009998 G2 box; other site 1303024009999 G3 box; other site 1303024010000 Switch II region; other site 1303024010001 G4 box; other site 1303024010002 G5 box; other site 1303024010003 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1303024010004 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1303024010005 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1303024010006 30S ribosomal protein S7; Validated; Region: PRK05302 1303024010007 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1303024010008 S17 interaction site [polypeptide binding]; other site 1303024010009 S8 interaction site; other site 1303024010010 16S rRNA interaction site [nucleotide binding]; other site 1303024010011 streptomycin interaction site [chemical binding]; other site 1303024010012 23S rRNA interaction site [nucleotide binding]; other site 1303024010013 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1303024010014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010016 WHG domain; Region: WHG; pfam13305 1303024010017 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1303024010018 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1303024010019 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1303024010020 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1303024010021 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1303024010022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024010023 substrate binding site [chemical binding]; other site 1303024010024 oxyanion hole (OAH) forming residues; other site 1303024010025 trimer interface [polypeptide binding]; other site 1303024010026 PaaX-like protein; Region: PaaX; pfam07848 1303024010027 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1303024010028 enoyl-CoA hydratase; Provisional; Region: PRK12478 1303024010029 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024010030 substrate binding site [chemical binding]; other site 1303024010031 oxyanion hole (OAH) forming residues; other site 1303024010032 trimer interface [polypeptide binding]; other site 1303024010033 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1303024010034 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024010035 active site 1303024010036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024010037 dimerization interface [polypeptide binding]; other site 1303024010038 putative DNA binding site [nucleotide binding]; other site 1303024010039 putative Zn2+ binding site [ion binding]; other site 1303024010040 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1303024010041 putative hydrophobic ligand binding site [chemical binding]; other site 1303024010042 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1303024010043 amino acid transporter; Region: 2A0306; TIGR00909 1303024010044 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1303024010045 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1303024010046 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1303024010047 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1303024010048 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1303024010049 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1303024010050 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1303024010051 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1303024010052 DNA binding site [nucleotide binding] 1303024010053 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1303024010054 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1303024010055 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1303024010056 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1303024010057 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1303024010058 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1303024010059 RPB10 interaction site [polypeptide binding]; other site 1303024010060 RPB1 interaction site [polypeptide binding]; other site 1303024010061 RPB11 interaction site [polypeptide binding]; other site 1303024010062 RPB3 interaction site [polypeptide binding]; other site 1303024010063 RPB12 interaction site [polypeptide binding]; other site 1303024010064 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1303024010065 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1303024010066 molybdopterin cofactor binding site; other site 1303024010067 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1303024010068 molybdopterin cofactor binding site; other site 1303024010069 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1303024010070 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1303024010071 Walker A/P-loop; other site 1303024010072 ATP binding site [chemical binding]; other site 1303024010073 Q-loop/lid; other site 1303024010074 ABC transporter signature motif; other site 1303024010075 Walker B; other site 1303024010076 D-loop; other site 1303024010077 H-loop/switch region; other site 1303024010078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024010079 putative substrate translocation pore; other site 1303024010080 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024010081 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1303024010082 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1303024010083 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1303024010084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010086 WHG domain; Region: WHG; pfam13305 1303024010087 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1303024010088 core dimer interface [polypeptide binding]; other site 1303024010089 peripheral dimer interface [polypeptide binding]; other site 1303024010090 L10 interface [polypeptide binding]; other site 1303024010091 L11 interface [polypeptide binding]; other site 1303024010092 putative EF-Tu interaction site [polypeptide binding]; other site 1303024010093 putative EF-G interaction site [polypeptide binding]; other site 1303024010094 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1303024010095 23S rRNA interface [nucleotide binding]; other site 1303024010096 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1303024010097 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024010098 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1303024010099 TAP-like protein; Region: Abhydrolase_4; pfam08386 1303024010100 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024010101 ABC1 family; Region: ABC1; pfam03109 1303024010102 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1303024010103 active site 1303024010104 ATP binding site [chemical binding]; other site 1303024010105 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024010106 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1303024010107 TAP-like protein; Region: Abhydrolase_4; pfam08386 1303024010108 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1303024010109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1303024010110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024010111 S-adenosylmethionine binding site [chemical binding]; other site 1303024010112 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1303024010113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010115 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1303024010116 FAD binding domain; Region: FAD_binding_4; pfam01565 1303024010117 diacylglycerol kinase; Reviewed; Region: PRK11914 1303024010118 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1303024010119 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024010120 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024010121 YCII-related domain; Region: YCII; cl00999 1303024010122 YCII-related domain; Region: YCII; cl00999 1303024010123 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1303024010124 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1303024010125 DNA binding residues [nucleotide binding] 1303024010126 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1303024010127 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1303024010128 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1303024010129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1303024010130 Histidine kinase; Region: HisKA_3; pfam07730 1303024010131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024010132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024010133 active site 1303024010134 phosphorylation site [posttranslational modification] 1303024010135 intermolecular recognition site; other site 1303024010136 dimerization interface [polypeptide binding]; other site 1303024010137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024010138 DNA binding residues [nucleotide binding] 1303024010139 dimerization interface [polypeptide binding]; other site 1303024010140 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1303024010141 mRNA/rRNA interface [nucleotide binding]; other site 1303024010142 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1303024010143 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1303024010144 23S rRNA interface [nucleotide binding]; other site 1303024010145 L7/L12 interface [polypeptide binding]; other site 1303024010146 putative thiostrepton binding site; other site 1303024010147 L25 interface [polypeptide binding]; other site 1303024010148 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1303024010149 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1303024010150 putative homodimer interface [polypeptide binding]; other site 1303024010151 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1303024010152 heterodimer interface [polypeptide binding]; other site 1303024010153 homodimer interface [polypeptide binding]; other site 1303024010154 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1303024010155 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1303024010156 (3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional; Region: PRK13693 1303024010157 active site 2 [active] 1303024010158 active site 1 [active] 1303024010159 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1303024010160 active site 1303024010161 catalytic site [active] 1303024010162 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1303024010163 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1303024010164 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1303024010165 dimerization interface [polypeptide binding]; other site 1303024010166 DPS ferroxidase diiron center [ion binding]; other site 1303024010167 ion pore; other site 1303024010168 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1303024010169 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1303024010170 proposed catalytic triad [active] 1303024010171 conserved cys residue [active] 1303024010172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1303024010173 Predicted kinase [General function prediction only]; Region: COG0645 1303024010174 AAA domain; Region: AAA_17; pfam13207 1303024010175 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1303024010176 dimer interface [polypeptide binding]; other site 1303024010177 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024010178 Ligand Binding Site [chemical binding]; other site 1303024010179 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1303024010180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024010181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024010182 DNA binding residues [nucleotide binding] 1303024010183 dimerization interface [polypeptide binding]; other site 1303024010184 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1303024010185 putative heme binding pocket [chemical binding]; other site 1303024010186 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 1303024010187 putative heme binding site [chemical binding]; other site 1303024010188 putative active site [active] 1303024010189 putative substrate binding site [chemical binding]; other site 1303024010190 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1303024010191 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1303024010192 active site 1303024010193 catalytic triad [active] 1303024010194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1303024010195 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1303024010196 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1303024010197 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1303024010198 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024010199 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1303024010200 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1303024010201 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1303024010202 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1303024010203 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1303024010204 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1303024010205 FAD binding pocket [chemical binding]; other site 1303024010206 FAD binding motif [chemical binding]; other site 1303024010207 phosphate binding motif [ion binding]; other site 1303024010208 beta-alpha-beta structure motif; other site 1303024010209 NAD(p) ribose binding residues [chemical binding]; other site 1303024010210 NAD binding pocket [chemical binding]; other site 1303024010211 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1303024010212 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024010213 catalytic loop [active] 1303024010214 iron binding site [ion binding]; other site 1303024010215 short chain dehydrogenase; Provisional; Region: PRK07832 1303024010216 classical (c) SDRs; Region: SDR_c; cd05233 1303024010217 NAD(P) binding site [chemical binding]; other site 1303024010218 active site 1303024010219 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024010220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024010221 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1303024010222 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1303024010223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010225 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024010226 CoenzymeA binding site [chemical binding]; other site 1303024010227 subunit interaction site [polypeptide binding]; other site 1303024010228 PHB binding site; other site 1303024010229 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024010230 TIGR03086 family protein; Region: TIGR03086 1303024010231 heat shock protein HtpX; Provisional; Region: PRK03072 1303024010232 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1303024010233 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1303024010234 substrate binding pocket [chemical binding]; other site 1303024010235 chain length determination region; other site 1303024010236 substrate-Mg2+ binding site; other site 1303024010237 catalytic residues [active] 1303024010238 aspartate-rich region 1; other site 1303024010239 active site lid residues [active] 1303024010240 aspartate-rich region 2; other site 1303024010241 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1303024010242 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1303024010243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024010244 S-adenosylmethionine binding site [chemical binding]; other site 1303024010245 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1303024010246 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1303024010247 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1303024010248 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1303024010249 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1303024010250 dimer interface [polypeptide binding]; other site 1303024010251 tetramer interface [polypeptide binding]; other site 1303024010252 PYR/PP interface [polypeptide binding]; other site 1303024010253 TPP binding site [chemical binding]; other site 1303024010254 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1303024010255 TPP-binding site; other site 1303024010256 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024010257 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1303024010258 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1303024010259 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1303024010260 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1303024010261 active site 1303024010262 Clp amino terminal domain; Region: Clp_N; pfam02861 1303024010263 Clp amino terminal domain; Region: Clp_N; pfam02861 1303024010264 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024010265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1303024010266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1303024010267 metal binding site [ion binding]; metal-binding site 1303024010268 active site 1303024010269 I-site; other site 1303024010270 Pirin-related protein [General function prediction only]; Region: COG1741 1303024010271 Pirin; Region: Pirin; pfam02678 1303024010272 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1303024010273 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1303024010274 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1303024010275 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1303024010276 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1303024010277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024010278 substrate binding site [chemical binding]; other site 1303024010279 oxyanion hole (OAH) forming residues; other site 1303024010280 trimer interface [polypeptide binding]; other site 1303024010281 short chain dehydrogenase; Provisional; Region: PRK08278 1303024010282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024010283 NAD(P) binding site [chemical binding]; other site 1303024010284 active site 1303024010285 short chain dehydrogenase; Provisional; Region: PRK05866 1303024010286 classical (c) SDRs; Region: SDR_c; cd05233 1303024010287 NAD(P) binding site [chemical binding]; other site 1303024010288 active site 1303024010289 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024010290 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1303024010291 active site 1303024010292 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1303024010293 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1303024010294 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1303024010295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024010296 active site 1303024010297 CoA binding site [chemical binding]; other site 1303024010298 AMP binding site [chemical binding]; other site 1303024010299 Cupin domain; Region: Cupin_2; pfam07883 1303024010300 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1303024010301 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024010302 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1303024010303 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1303024010304 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1303024010305 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1303024010306 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1303024010307 UbiA prenyltransferase family; Region: UbiA; pfam01040 1303024010308 Clp amino terminal domain; Region: Clp_N; pfam02861 1303024010309 Clp amino terminal domain; Region: Clp_N; pfam02861 1303024010310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1303024010311 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024010312 Cytochrome P450; Region: p450; cl12078 1303024010313 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024010314 Cytochrome P450; Region: p450; cl12078 1303024010315 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024010316 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1303024010317 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1303024010318 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1303024010319 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024010320 catalytic residue [active] 1303024010321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024010322 NAD(P) binding site [chemical binding]; other site 1303024010323 active site 1303024010324 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024010325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024010326 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1303024010327 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1303024010328 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1303024010329 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1303024010330 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1303024010331 ResB-like family; Region: ResB; pfam05140 1303024010332 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1303024010333 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1303024010334 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1303024010335 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1303024010336 catalytic residues [active] 1303024010337 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024010338 catalytic core [active] 1303024010339 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1303024010340 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024010341 inhibitor-cofactor binding pocket; inhibition site 1303024010342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024010343 catalytic residue [active] 1303024010344 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024010345 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1303024010346 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1303024010347 active site 1303024010348 Zn binding site [ion binding]; other site 1303024010349 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1303024010350 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1303024010351 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1303024010352 metal-binding site [ion binding] 1303024010353 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1303024010354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024010355 motif II; other site 1303024010356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024010357 S-adenosylmethionine binding site [chemical binding]; other site 1303024010358 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1303024010359 dimer interface [polypeptide binding]; other site 1303024010360 active site 1303024010361 Schiff base residues; other site 1303024010362 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1303024010363 active site 1303024010364 homodimer interface [polypeptide binding]; other site 1303024010365 SAM binding site [chemical binding]; other site 1303024010366 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1303024010367 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1303024010368 active site 1303024010369 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1303024010370 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1303024010371 domain interfaces; other site 1303024010372 active site 1303024010373 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1303024010374 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1303024010375 tRNA; other site 1303024010376 putative tRNA binding site [nucleotide binding]; other site 1303024010377 putative NADP binding site [chemical binding]; other site 1303024010378 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1303024010379 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1303024010380 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1303024010381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024010382 motif II; other site 1303024010383 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1303024010384 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1303024010385 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024010386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024010387 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1303024010388 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1303024010389 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1303024010390 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1303024010391 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1303024010392 FMN binding site [chemical binding]; other site 1303024010393 substrate binding site [chemical binding]; other site 1303024010394 putative catalytic residue [active] 1303024010395 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1303024010396 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1303024010397 putative acyl-acceptor binding pocket; other site 1303024010398 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1303024010399 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1303024010400 putative NAD(P) binding site [chemical binding]; other site 1303024010401 active site 1303024010402 putative substrate binding site [chemical binding]; other site 1303024010403 DNA binding domain, excisionase family; Region: excise; TIGR01764 1303024010404 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1303024010405 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1303024010406 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024010407 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024010408 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1303024010409 active site 1303024010410 diiron metal binding site [ion binding]; other site 1303024010411 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024010412 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1303024010413 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1303024010414 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1303024010415 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1303024010416 DNA interaction; other site 1303024010417 Metal-binding active site; metal-binding site 1303024010418 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1303024010419 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1303024010420 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1303024010421 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1303024010422 putative hydrophobic ligand binding site [chemical binding]; other site 1303024010423 protein interface [polypeptide binding]; other site 1303024010424 gate; other site 1303024010425 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024010426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024010427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024010428 S-adenosylmethionine binding site [chemical binding]; other site 1303024010429 short chain dehydrogenase; Validated; Region: PRK05855 1303024010430 classical (c) SDRs; Region: SDR_c; cd05233 1303024010431 NAD(P) binding site [chemical binding]; other site 1303024010432 active site 1303024010433 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1303024010434 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1303024010435 FMN-binding pocket [chemical binding]; other site 1303024010436 flavin binding motif; other site 1303024010437 phosphate binding motif [ion binding]; other site 1303024010438 beta-alpha-beta structure motif; other site 1303024010439 NAD binding pocket [chemical binding]; other site 1303024010440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024010441 catalytic loop [active] 1303024010442 iron binding site [ion binding]; other site 1303024010443 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024010444 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024010445 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1303024010446 classical (c) SDRs; Region: SDR_c; cd05233 1303024010447 NAD(P) binding site [chemical binding]; other site 1303024010448 active site 1303024010449 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024010450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024010451 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024010452 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024010453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010457 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1303024010458 Permease; Region: Permease; pfam02405 1303024010459 Permease; Region: Permease; pfam02405 1303024010460 mce related protein; Region: MCE; pfam02470 1303024010461 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1303024010462 mce related protein; Region: MCE; pfam02470 1303024010463 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010464 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010465 mce related protein; Region: MCE; pfam02470 1303024010466 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010467 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010468 mce related protein; Region: MCE; pfam02470 1303024010469 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010470 mce related protein; Region: MCE; pfam02470 1303024010471 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1303024010472 putative hydrophobic ligand binding site [chemical binding]; other site 1303024010473 protein interface [polypeptide binding]; other site 1303024010474 gate; other site 1303024010475 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024010476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024010477 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1303024010478 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024010479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024010480 short chain dehydrogenase; Provisional; Region: PRK07825 1303024010481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024010482 NAD(P) binding site [chemical binding]; other site 1303024010483 active site 1303024010484 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024010485 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1303024010486 ABC1 family; Region: ABC1; cl17513 1303024010487 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1303024010488 active site 1303024010489 ATP binding site [chemical binding]; other site 1303024010490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024010495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024010496 active site 1303024010497 phosphorylation site [posttranslational modification] 1303024010498 intermolecular recognition site; other site 1303024010499 dimerization interface [polypeptide binding]; other site 1303024010500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024010501 DNA binding site [nucleotide binding] 1303024010502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024010503 dimer interface [polypeptide binding]; other site 1303024010504 phosphorylation site [posttranslational modification] 1303024010505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024010506 ATP binding site [chemical binding]; other site 1303024010507 Mg2+ binding site [ion binding]; other site 1303024010508 G-X-G motif; other site 1303024010509 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024010510 catalytic core [active] 1303024010511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1303024010512 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024010513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024010514 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1303024010515 dinuclear metal binding motif [ion binding]; other site 1303024010516 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024010517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024010518 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1303024010519 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1303024010520 short chain dehydrogenase; Provisional; Region: PRK06181 1303024010521 classical (c) SDRs; Region: SDR_c; cd05233 1303024010522 NAD(P) binding site [chemical binding]; other site 1303024010523 active site 1303024010524 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1303024010525 4-coumarate--CoA ligase; Region: PLN02246 1303024010526 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 1303024010527 acyl-activating enzyme (AAE) consensus motif; other site 1303024010528 active site 1303024010529 putative CoA binding site [chemical binding]; other site 1303024010530 AMP binding site [chemical binding]; other site 1303024010531 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1303024010532 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1303024010533 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1303024010534 putative ADP-binding pocket [chemical binding]; other site 1303024010535 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1303024010536 hydrophobic ligand binding site; other site 1303024010537 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1303024010538 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1303024010539 short chain dehydrogenase; Provisional; Region: PRK06523 1303024010540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024010541 NAD(P) binding site [chemical binding]; other site 1303024010542 active site 1303024010543 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1303024010544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1303024010545 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1303024010546 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1303024010547 Predicted transcriptional regulators [Transcription]; Region: COG1733 1303024010548 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1303024010549 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024010550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024010551 putative substrate translocation pore; other site 1303024010552 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1303024010553 FAD binding domain; Region: FAD_binding_4; pfam01565 1303024010554 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1303024010555 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1303024010556 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1303024010557 CHAT domain; Region: CHAT; cl17868 1303024010558 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1303024010559 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1303024010560 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1303024010561 putative active site [active] 1303024010562 catalytic triad [active] 1303024010563 putative dimer interface [polypeptide binding]; other site 1303024010564 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1303024010565 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1303024010566 intersubunit interface [polypeptide binding]; other site 1303024010567 active site 1303024010568 catalytic residue [active] 1303024010569 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1303024010570 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1303024010571 tetramer interface [polypeptide binding]; other site 1303024010572 active site 1303024010573 Mg2+/Mn2+ binding site [ion binding]; other site 1303024010574 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1303024010575 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1303024010576 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1303024010577 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024010578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024010579 non-specific DNA binding site [nucleotide binding]; other site 1303024010580 salt bridge; other site 1303024010581 sequence-specific DNA binding site [nucleotide binding]; other site 1303024010582 Predicted membrane protein [Function unknown]; Region: COG2733 1303024010583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010585 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1303024010586 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1303024010587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024010588 S-adenosylmethionine binding site [chemical binding]; other site 1303024010589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010591 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1303024010592 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1303024010593 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1303024010594 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1303024010595 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1303024010596 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1303024010597 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1303024010598 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1303024010599 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1303024010600 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1303024010601 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1303024010602 isocitrate lyase; Provisional; Region: PRK15063 1303024010603 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1303024010604 tetramer interface [polypeptide binding]; other site 1303024010605 active site 1303024010606 Mg2+/Mn2+ binding site [ion binding]; other site 1303024010607 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1303024010608 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024010609 active site 2 [active] 1303024010610 active site 1 [active] 1303024010611 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024010612 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1303024010613 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1303024010614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024010615 NAD(P) binding site [chemical binding]; other site 1303024010616 active site 1303024010617 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1303024010618 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1303024010619 homodimer interface [polypeptide binding]; other site 1303024010620 active site 1303024010621 TDP-binding site; other site 1303024010622 acceptor substrate-binding pocket; other site 1303024010623 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1303024010624 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1303024010625 substrate binding site; other site 1303024010626 tetramer interface; other site 1303024010627 Transport protein; Region: actII; TIGR00833 1303024010628 Transport protein; Region: actII; TIGR00833 1303024010629 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024010630 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024010631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024010632 non-specific DNA binding site [nucleotide binding]; other site 1303024010633 salt bridge; other site 1303024010634 sequence-specific DNA binding site [nucleotide binding]; other site 1303024010635 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1303024010636 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1303024010637 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1303024010638 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1303024010639 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1303024010640 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1303024010641 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1303024010642 active site 1303024010643 catalytic tetrad [active] 1303024010644 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1303024010645 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1303024010646 DNA binding residues [nucleotide binding] 1303024010647 putative dimer interface [polypeptide binding]; other site 1303024010648 Amino acid permease; Region: AA_permease_2; pfam13520 1303024010649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024010650 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1303024010651 active site 1303024010652 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1303024010653 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1303024010654 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1303024010655 non-prolyl cis peptide bond; other site 1303024010656 active site 1303024010657 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024010658 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1303024010659 active site clefts [active] 1303024010660 zinc binding site [ion binding]; other site 1303024010661 dimer interface [polypeptide binding]; other site 1303024010662 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1303024010663 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1303024010664 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024010665 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1303024010666 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1303024010667 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024010668 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024010669 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1303024010670 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024010671 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1303024010672 NAD(P) binding site [chemical binding]; other site 1303024010673 catalytic residues [active] 1303024010674 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1303024010675 DinB superfamily; Region: DinB_2; pfam12867 1303024010676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024010677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024010678 putative substrate translocation pore; other site 1303024010679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024010680 dimerization interface [polypeptide binding]; other site 1303024010681 putative DNA binding site [nucleotide binding]; other site 1303024010682 putative Zn2+ binding site [ion binding]; other site 1303024010683 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1303024010684 putative hydrophobic ligand binding site [chemical binding]; other site 1303024010685 PE-PPE domain; Region: PE-PPE; pfam08237 1303024010686 YHYH protein; Region: YHYH; pfam14240 1303024010687 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1303024010688 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1303024010689 active site 1303024010690 homotetramer interface [polypeptide binding]; other site 1303024010691 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010692 mce related protein; Region: MCE; pfam02470 1303024010693 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010694 mce related protein; Region: MCE; pfam02470 1303024010695 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010696 mce related protein; Region: MCE; pfam02470 1303024010697 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010698 mce related protein; Region: MCE; pfam02470 1303024010699 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1303024010700 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024010701 mce related protein; Region: MCE; pfam02470 1303024010702 mce related protein; Region: MCE; pfam02470 1303024010703 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1303024010704 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1303024010705 Permease; Region: Permease; pfam02405 1303024010706 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1303024010707 Permease; Region: Permease; pfam02405 1303024010708 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1303024010709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024010710 NAD(P) binding site [chemical binding]; other site 1303024010711 active site 1303024010712 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1303024010713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024010714 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1303024010715 FAD binding site [chemical binding]; other site 1303024010716 substrate binding site [chemical binding]; other site 1303024010717 catalytic base [active] 1303024010718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024010719 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024010720 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1303024010721 active site 1303024010722 acyl-CoA synthetase; Validated; Region: PRK07867 1303024010723 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024010724 acyl-activating enzyme (AAE) consensus motif; other site 1303024010725 AMP binding site [chemical binding]; other site 1303024010726 active site 1303024010727 CoA binding site [chemical binding]; other site 1303024010728 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1303024010729 Nitronate monooxygenase; Region: NMO; pfam03060 1303024010730 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1303024010731 FMN binding site [chemical binding]; other site 1303024010732 substrate binding site [chemical binding]; other site 1303024010733 putative catalytic residue [active] 1303024010734 acyl-CoA synthetase; Validated; Region: PRK07798 1303024010735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024010736 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1303024010737 acyl-activating enzyme (AAE) consensus motif; other site 1303024010738 acyl-activating enzyme (AAE) consensus motif; other site 1303024010739 putative AMP binding site [chemical binding]; other site 1303024010740 putative active site [active] 1303024010741 putative CoA binding site [chemical binding]; other site 1303024010742 enoyl-CoA hydratase; Provisional; Region: PRK07799 1303024010743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024010744 substrate binding site [chemical binding]; other site 1303024010745 oxyanion hole (OAH) forming residues; other site 1303024010746 trimer interface [polypeptide binding]; other site 1303024010747 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1303024010748 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1303024010749 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024010750 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1303024010751 DUF35 OB-fold domain; Region: DUF35; pfam01796 1303024010752 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1303024010753 DUF35 OB-fold domain; Region: DUF35; pfam01796 1303024010754 lipid-transfer protein; Provisional; Region: PRK07937 1303024010755 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024010756 active site 1303024010757 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1303024010758 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1303024010759 active site 1303024010760 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1303024010761 ferredoxin-NADP+ reductase; Region: PLN02852 1303024010762 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024010763 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1303024010764 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1303024010765 trimer interface [polypeptide binding]; other site 1303024010766 putative metal binding site [ion binding]; other site 1303024010767 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1303024010768 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1303024010769 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1303024010770 putative active site [active] 1303024010771 dimerization interface [polypeptide binding]; other site 1303024010772 putative tRNAtyr binding site [nucleotide binding]; other site 1303024010773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1303024010774 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1303024010775 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1303024010776 short chain dehydrogenase; Provisional; Region: PRK07890 1303024010777 classical (c) SDRs; Region: SDR_c; cd05233 1303024010778 NAD(P) binding site [chemical binding]; other site 1303024010779 active site 1303024010780 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1303024010781 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1303024010782 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1303024010783 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1303024010784 Active Sites [active] 1303024010785 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1303024010786 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1303024010787 CysD dimerization site [polypeptide binding]; other site 1303024010788 G1 box; other site 1303024010789 putative GEF interaction site [polypeptide binding]; other site 1303024010790 GTP/Mg2+ binding site [chemical binding]; other site 1303024010791 Switch I region; other site 1303024010792 G2 box; other site 1303024010793 G3 box; other site 1303024010794 Switch II region; other site 1303024010795 G4 box; other site 1303024010796 G5 box; other site 1303024010797 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1303024010798 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1303024010799 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1303024010800 ligand-binding site [chemical binding]; other site 1303024010801 carboxylate-amine ligase; Provisional; Region: PRK13517 1303024010802 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1303024010803 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1303024010804 E-class dimer interface [polypeptide binding]; other site 1303024010805 P-class dimer interface [polypeptide binding]; other site 1303024010806 active site 1303024010807 Cu2+ binding site [ion binding]; other site 1303024010808 Zn2+ binding site [ion binding]; other site 1303024010809 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1303024010810 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1303024010811 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1303024010812 active site 1303024010813 catalytic residues [active] 1303024010814 metal binding site [ion binding]; metal-binding site 1303024010815 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1303024010816 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1303024010817 putative catalytic site [active] 1303024010818 putative phosphate binding site [ion binding]; other site 1303024010819 active site 1303024010820 metal binding site A [ion binding]; metal-binding site 1303024010821 DNA binding site [nucleotide binding] 1303024010822 putative AP binding site [nucleotide binding]; other site 1303024010823 putative metal binding site B [ion binding]; other site 1303024010824 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1303024010825 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1303024010826 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1303024010827 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1303024010828 EspG family; Region: ESX-1_EspG; pfam14011 1303024010829 PPE family; Region: PPE; pfam00823 1303024010830 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1303024010831 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1303024010832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024010833 Walker A motif; other site 1303024010834 ATP binding site [chemical binding]; other site 1303024010835 Walker B motif; other site 1303024010836 arginine finger; other site 1303024010837 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1303024010838 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1303024010839 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1303024010840 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1303024010841 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1303024010842 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024010843 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1303024010844 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024010845 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024010846 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1303024010847 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1303024010848 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1303024010849 active site 1303024010850 catalytic residues [active] 1303024010851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024010852 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1303024010853 NAD(P) binding site [chemical binding]; other site 1303024010854 active site 1303024010855 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1303024010856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024010857 putative substrate translocation pore; other site 1303024010858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024010859 putative substrate translocation pore; other site 1303024010860 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1303024010861 ThiC-associated domain; Region: ThiC-associated; pfam13667 1303024010862 ThiC family; Region: ThiC; pfam01964 1303024010863 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1303024010864 dimer interface [polypeptide binding]; other site 1303024010865 substrate binding site [chemical binding]; other site 1303024010866 ATP binding site [chemical binding]; other site 1303024010867 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1303024010868 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1303024010869 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024010870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024010871 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1303024010872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024010873 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1303024010874 DNA binding residues [nucleotide binding] 1303024010875 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1303024010876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024010877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024010878 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1303024010879 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1303024010880 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024010881 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1303024010882 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1303024010883 tetrameric interface [polypeptide binding]; other site 1303024010884 NAD binding site [chemical binding]; other site 1303024010885 catalytic residues [active] 1303024010886 substrate binding site [chemical binding]; other site 1303024010887 tyramine oxidase; Provisional; Region: tynA; PRK11504 1303024010888 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1303024010889 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1303024010890 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1303024010891 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1303024010892 Ligand Binding Site [chemical binding]; other site 1303024010893 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1303024010894 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1303024010895 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024010896 inhibitor-cofactor binding pocket; inhibition site 1303024010897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024010898 catalytic residue [active] 1303024010899 succinic semialdehyde dehydrogenase; Region: PLN02278 1303024010900 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1303024010901 tetramerization interface [polypeptide binding]; other site 1303024010902 NAD(P) binding site [chemical binding]; other site 1303024010903 catalytic residues [active] 1303024010904 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1303024010905 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1303024010906 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1303024010907 putative active site [active] 1303024010908 putative CoA binding site [chemical binding]; other site 1303024010909 nudix motif; other site 1303024010910 metal binding site [ion binding]; metal-binding site 1303024010911 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1303024010912 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1303024010913 PA/protease or protease-like domain interface [polypeptide binding]; other site 1303024010914 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1303024010915 Peptidase family M28; Region: Peptidase_M28; pfam04389 1303024010916 active site 1303024010917 metal binding site [ion binding]; metal-binding site 1303024010918 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1303024010919 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1303024010920 PA/protease or protease-like domain interface [polypeptide binding]; other site 1303024010921 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1303024010922 Peptidase family M28; Region: Peptidase_M28; pfam04389 1303024010923 active site 1303024010924 metal binding site [ion binding]; metal-binding site 1303024010925 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1303024010926 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1303024010927 Walker A/P-loop; other site 1303024010928 ATP binding site [chemical binding]; other site 1303024010929 Q-loop/lid; other site 1303024010930 ABC transporter signature motif; other site 1303024010931 Walker B; other site 1303024010932 D-loop; other site 1303024010933 H-loop/switch region; other site 1303024010934 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1303024010935 ThiS interaction site; other site 1303024010936 putative active site [active] 1303024010937 tetramer interface [polypeptide binding]; other site 1303024010938 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1303024010939 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1303024010940 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1303024010941 thiamine phosphate binding site [chemical binding]; other site 1303024010942 active site 1303024010943 pyrophosphate binding site [ion binding]; other site 1303024010944 PAS fold; Region: PAS_3; pfam08447 1303024010945 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1303024010946 nudix motif; other site 1303024010947 tyrosine kinase; Provisional; Region: PRK11519 1303024010948 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1303024010949 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1303024010950 substrate binding pocket [chemical binding]; other site 1303024010951 membrane-bound complex binding site; other site 1303024010952 hinge residues; other site 1303024010953 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1303024010954 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1303024010955 active site 1303024010956 ATP binding site [chemical binding]; other site 1303024010957 substrate binding site [chemical binding]; other site 1303024010958 activation loop (A-loop); other site 1303024010959 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1303024010960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1303024010961 binding surface 1303024010962 TPR motif; other site 1303024010963 propionate/acetate kinase; Provisional; Region: PRK12379 1303024010964 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1303024010965 phosphate acetyltransferase; Reviewed; Region: PRK05632 1303024010966 DRTGG domain; Region: DRTGG; pfam07085 1303024010967 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1303024010968 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1303024010969 active site 1303024010970 catalytic site [active] 1303024010971 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1303024010972 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1303024010973 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024010974 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1303024010975 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024010976 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024010977 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1303024010978 active site 1303024010979 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1303024010980 non-prolyl cis peptide bond; other site 1303024010981 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1303024010982 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1303024010983 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1303024010984 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024010985 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1303024010986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024010987 Coenzyme A binding pocket [chemical binding]; other site 1303024010988 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1303024010989 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1303024010990 substrate binding pocket [chemical binding]; other site 1303024010991 membrane-bound complex binding site; other site 1303024010992 hinge residues; other site 1303024010993 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1303024010994 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1303024010995 Walker A/P-loop; other site 1303024010996 ATP binding site [chemical binding]; other site 1303024010997 Q-loop/lid; other site 1303024010998 ABC transporter signature motif; other site 1303024010999 Walker B; other site 1303024011000 D-loop; other site 1303024011001 H-loop/switch region; other site 1303024011002 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1303024011003 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1303024011004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1303024011005 dimer interface [polypeptide binding]; other site 1303024011006 conserved gate region; other site 1303024011007 putative PBP binding loops; other site 1303024011008 ABC-ATPase subunit interface; other site 1303024011009 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1303024011010 Transport protein; Region: actII; TIGR00833 1303024011011 Signal peptidase subunit; Region: SPC22; cl04601 1303024011012 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1303024011013 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1303024011014 homodimer interface [polypeptide binding]; other site 1303024011015 substrate-cofactor binding pocket; other site 1303024011016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024011017 catalytic residue [active] 1303024011018 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1303024011019 active site residue [active] 1303024011020 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 1303024011021 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1303024011022 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1303024011023 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1303024011024 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1303024011025 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024011026 CoenzymeA binding site [chemical binding]; other site 1303024011027 subunit interaction site [polypeptide binding]; other site 1303024011028 PHB binding site; other site 1303024011029 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1303024011030 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1303024011031 GDP-binding site [chemical binding]; other site 1303024011032 ACT binding site; other site 1303024011033 IMP binding site; other site 1303024011034 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1303024011035 Peptidase family M50; Region: Peptidase_M50; pfam02163 1303024011036 active site 1303024011037 putative substrate binding region [chemical binding]; other site 1303024011038 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1303024011039 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1303024011040 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1303024011041 active site 1303024011042 intersubunit interface [polypeptide binding]; other site 1303024011043 zinc binding site [ion binding]; other site 1303024011044 Na+ binding site [ion binding]; other site 1303024011045 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1303024011046 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1303024011047 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1303024011048 active site 1303024011049 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1303024011050 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1303024011051 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1303024011052 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1303024011053 active site 1303024011054 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1303024011055 classical (c) SDRs; Region: SDR_c; cd05233 1303024011056 NAD(P) binding site [chemical binding]; other site 1303024011057 active site 1303024011058 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024011059 Transport protein; Region: actII; TIGR00833 1303024011060 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1303024011061 Clp amino terminal domain; Region: Clp_N; pfam02861 1303024011062 Clp amino terminal domain; Region: Clp_N; pfam02861 1303024011063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024011064 Walker A motif; other site 1303024011065 ATP binding site [chemical binding]; other site 1303024011066 Walker B motif; other site 1303024011067 arginine finger; other site 1303024011068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024011069 Walker A motif; other site 1303024011070 ATP binding site [chemical binding]; other site 1303024011071 Walker B motif; other site 1303024011072 arginine finger; other site 1303024011073 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1303024011074 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1303024011075 putative hydrophobic ligand binding site [chemical binding]; other site 1303024011076 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1303024011077 putative hydrophobic ligand binding site [chemical binding]; other site 1303024011078 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1303024011079 putative hydrophobic ligand binding site [chemical binding]; other site 1303024011080 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1303024011081 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1303024011082 heme-binding site [chemical binding]; other site 1303024011083 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1303024011084 FAD binding pocket [chemical binding]; other site 1303024011085 FAD binding motif [chemical binding]; other site 1303024011086 phosphate binding motif [ion binding]; other site 1303024011087 beta-alpha-beta structure motif; other site 1303024011088 NAD binding pocket [chemical binding]; other site 1303024011089 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1303024011090 DNA binding residues [nucleotide binding] 1303024011091 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1303024011092 putative dimer interface [polypeptide binding]; other site 1303024011093 chaperone protein DnaJ; Provisional; Region: PRK14279 1303024011094 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1303024011095 HSP70 interaction site [polypeptide binding]; other site 1303024011096 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1303024011097 Zn binding sites [ion binding]; other site 1303024011098 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1303024011099 dimer interface [polypeptide binding]; other site 1303024011100 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1303024011101 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1303024011102 dimer interface [polypeptide binding]; other site 1303024011103 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1303024011104 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1303024011105 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1303024011106 nucleotide binding site [chemical binding]; other site 1303024011107 NEF interaction site [polypeptide binding]; other site 1303024011108 SBD interface [polypeptide binding]; other site 1303024011109 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1303024011110 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1303024011111 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1303024011112 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1303024011113 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024011114 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1303024011115 G1 box; other site 1303024011116 GTP/Mg2+ binding site [chemical binding]; other site 1303024011117 G2 box; other site 1303024011118 Switch I region; other site 1303024011119 G3 box; other site 1303024011120 Switch II region; other site 1303024011121 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1303024011122 Dynamin family; Region: Dynamin_N; pfam00350 1303024011123 G1 box; other site 1303024011124 GTP/Mg2+ binding site [chemical binding]; other site 1303024011125 G2 box; other site 1303024011126 Switch I region; other site 1303024011127 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1303024011128 G3 box; other site 1303024011129 Switch II region; other site 1303024011130 GTP/Mg2+ binding site [chemical binding]; other site 1303024011131 G4 box; other site 1303024011132 G5 box; other site 1303024011133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024011134 Transposase; Region: HTH_Tnp_1; cl17663 1303024011135 putative transposase OrfB; Reviewed; Region: PHA02517 1303024011136 HTH-like domain; Region: HTH_21; pfam13276 1303024011137 Integrase core domain; Region: rve; pfam00665 1303024011138 Integrase core domain; Region: rve_3; pfam13683 1303024011139 Thioredoxin; Region: Thioredoxin_4; pfam13462 1303024011140 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1303024011141 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1303024011142 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1303024011143 Penicillinase repressor; Region: Pencillinase_R; cl17580 1303024011144 Peptidase family M48; Region: Peptidase_M48; cl12018 1303024011145 Predicted membrane protein [Function unknown]; Region: COG2259 1303024011146 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1303024011147 nucleotide binding site [chemical binding]; other site 1303024011148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024011149 dimerization interface [polypeptide binding]; other site 1303024011150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024011151 DNA binding residues [nucleotide binding] 1303024011152 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1303024011153 4Fe-4S binding domain; Region: Fer4; cl02805 1303024011154 Cysteine-rich domain; Region: CCG; pfam02754 1303024011155 Cysteine-rich domain; Region: CCG; pfam02754 1303024011156 aminotransferase AlaT; Validated; Region: PRK09265 1303024011157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1303024011158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024011159 homodimer interface [polypeptide binding]; other site 1303024011160 catalytic residue [active] 1303024011161 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1303024011162 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1303024011163 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1303024011164 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1303024011165 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1303024011166 trimer interface [polypeptide binding]; other site 1303024011167 active site 1303024011168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1303024011169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1303024011170 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024011171 alpha-galactosidase; Region: PLN02229 1303024011172 alpha-galactosidase; Region: PLN02808; cl17638 1303024011173 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1303024011174 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1303024011175 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1303024011176 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1303024011177 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1303024011178 Sulfatase; Region: Sulfatase; pfam00884 1303024011179 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 1303024011180 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1303024011181 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1303024011182 Transport protein; Region: actII; TIGR00833 1303024011183 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024011184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1303024011187 active site 1303024011188 DNA binding site [nucleotide binding] 1303024011189 Int/Topo IB signature motif; other site 1303024011190 Helix-turn-helix domain; Region: HTH_17; cl17695 1303024011191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024011192 Q-loop/lid; other site 1303024011193 Helix-turn-helix domain; Region: HTH_17; pfam12728 1303024011194 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 1303024011195 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024011196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024011197 S-adenosylmethionine binding site [chemical binding]; other site 1303024011198 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024011199 MULE transposase domain; Region: MULE; pfam10551 1303024011200 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1303024011201 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1303024011202 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 1303024011203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024011204 non-specific DNA binding site [nucleotide binding]; other site 1303024011205 salt bridge; other site 1303024011206 sequence-specific DNA binding site [nucleotide binding]; other site 1303024011207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024011210 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1303024011211 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024011212 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1303024011213 NAD(P) binding site [chemical binding]; other site 1303024011214 catalytic residues [active] 1303024011215 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1303024011216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1303024011217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1303024011218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024011219 Coenzyme A binding pocket [chemical binding]; other site 1303024011220 putative transposase OrfB; Reviewed; Region: PHA02517 1303024011221 HTH-like domain; Region: HTH_21; pfam13276 1303024011222 Integrase core domain; Region: rve; pfam00665 1303024011223 Integrase core domain; Region: rve_3; cl15866 1303024011224 Transposase; Region: HTH_Tnp_1; cl17663 1303024011225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024011226 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024011227 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024011228 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024011229 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1303024011230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011231 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1303024011232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024011233 Zn binding site [ion binding]; other site 1303024011234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024011237 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1303024011238 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 1303024011239 putative ligand binding site [chemical binding]; other site 1303024011240 putative NAD binding site [chemical binding]; other site 1303024011241 catalytic site [active] 1303024011242 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 1303024011243 classical (c) SDRs; Region: SDR_c; cd05233 1303024011244 NAD(P) binding site [chemical binding]; other site 1303024011245 active site 1303024011246 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024011247 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1303024011248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024011249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024011250 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1303024011251 FAD binding site [chemical binding]; other site 1303024011252 substrate binding site [chemical binding]; other site 1303024011253 catalytic base [active] 1303024011254 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1303024011255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024011256 nucleophilic elbow; other site 1303024011257 catalytic triad; other site 1303024011258 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1303024011259 putative hydrophobic ligand binding site [chemical binding]; other site 1303024011260 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1303024011261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024011262 acyl-CoA synthetase; Validated; Region: PRK07788 1303024011263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024011264 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1303024011265 acyl-activating enzyme (AAE) consensus motif; other site 1303024011266 acyl-activating enzyme (AAE) consensus motif; other site 1303024011267 putative AMP binding site [chemical binding]; other site 1303024011268 putative active site [active] 1303024011269 putative CoA binding site [chemical binding]; other site 1303024011270 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1303024011271 nucleotide binding site [chemical binding]; other site 1303024011272 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1303024011273 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024011274 acyl-activating enzyme (AAE) consensus motif; other site 1303024011275 AMP binding site [chemical binding]; other site 1303024011276 active site 1303024011277 CoA binding site [chemical binding]; other site 1303024011278 AMP-binding domain protein; Validated; Region: PRK08315 1303024011279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024011280 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1303024011281 acyl-activating enzyme (AAE) consensus motif; other site 1303024011282 putative AMP binding site [chemical binding]; other site 1303024011283 putative active site [active] 1303024011284 putative CoA binding site [chemical binding]; other site 1303024011285 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1303024011286 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1303024011287 putative active site [active] 1303024011288 putative catalytic site [active] 1303024011289 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1303024011290 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1303024011291 Bacterial transcriptional regulator; Region: IclR; pfam01614 1303024011292 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024011293 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024011294 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024011295 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1303024011296 dimerization interface [polypeptide binding]; other site 1303024011297 formate dehydrogenase; Provisional; Region: PRK07574 1303024011298 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1303024011299 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1303024011300 heme binding pocket [chemical binding]; other site 1303024011301 choline dehydrogenase; Validated; Region: PRK02106 1303024011302 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1303024011303 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1303024011304 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1303024011305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024011306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1303024011307 dimerization interface [polypeptide binding]; other site 1303024011308 Lysine efflux permease [General function prediction only]; Region: COG1279 1303024011309 GXWXG protein; Region: GXWXG; pfam14231 1303024011310 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1303024011311 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1303024011312 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1303024011313 catalytic Zn binding site [ion binding]; other site 1303024011314 NAD binding site [chemical binding]; other site 1303024011315 structural Zn binding site [ion binding]; other site 1303024011316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011318 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1303024011319 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1303024011320 intersubunit interface [polypeptide binding]; other site 1303024011321 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1303024011322 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1303024011323 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1303024011324 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1303024011325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1303024011326 Coenzyme A binding pocket [chemical binding]; other site 1303024011327 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1303024011328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1303024011329 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1303024011330 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1303024011331 putative dimer interface [polypeptide binding]; other site 1303024011332 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1303024011333 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1303024011334 homodimer interface [polypeptide binding]; other site 1303024011335 putative substrate binding pocket [chemical binding]; other site 1303024011336 diiron center [ion binding]; other site 1303024011337 Cutinase; Region: Cutinase; pfam01083 1303024011338 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1303024011339 Isochorismatase family; Region: Isochorismatase; pfam00857 1303024011340 catalytic triad [active] 1303024011341 conserved cis-peptide bond; other site 1303024011342 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1303024011343 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1303024011344 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1303024011345 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1303024011346 dimer interface [polypeptide binding]; other site 1303024011347 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1303024011348 catalytic triad [active] 1303024011349 peroxidatic and resolving cysteines [active] 1303024011350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024011351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024011352 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1303024011353 MULE transposase domain; Region: MULE; pfam10551 1303024011354 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1303024011355 dimerization interface [polypeptide binding]; other site 1303024011356 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1303024011357 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1303024011358 tetramer interface [polypeptide binding]; other site 1303024011359 active site 1303024011360 Mg2+/Mn2+ binding site [ion binding]; other site 1303024011361 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1303024011362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024011363 DNA-binding site [nucleotide binding]; DNA binding site 1303024011364 FCD domain; Region: FCD; pfam07729 1303024011365 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1303024011366 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1303024011367 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1303024011368 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1303024011369 NAD binding site [chemical binding]; other site 1303024011370 ligand binding site [chemical binding]; other site 1303024011371 catalytic site [active] 1303024011372 putative amidase; Provisional; Region: PRK06169 1303024011373 Amidase; Region: Amidase; pfam01425 1303024011374 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 1303024011375 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1303024011376 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1303024011377 inhibitor-cofactor binding pocket; inhibition site 1303024011378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1303024011379 catalytic residue [active] 1303024011380 succinic semialdehyde dehydrogenase; Region: PLN02278 1303024011381 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1303024011382 tetramerization interface [polypeptide binding]; other site 1303024011383 NAD(P) binding site [chemical binding]; other site 1303024011384 catalytic residues [active] 1303024011385 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1303024011386 tartrate dehydrogenase; Provisional; Region: PRK08194 1303024011387 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1303024011388 L-aspartate oxidase; Provisional; Region: PRK06175 1303024011389 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1303024011390 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1303024011391 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1303024011392 catalytic loop [active] 1303024011393 iron binding site [ion binding]; other site 1303024011394 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1303024011395 hydrophobic ligand binding site; other site 1303024011396 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024011397 dimerization interface [polypeptide binding]; other site 1303024011398 putative DNA binding site [nucleotide binding]; other site 1303024011399 putative Zn2+ binding site [ion binding]; other site 1303024011400 Predicted transcriptional regulators [Transcription]; Region: COG1733 1303024011401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024011402 dimerization interface [polypeptide binding]; other site 1303024011403 putative DNA binding site [nucleotide binding]; other site 1303024011404 putative Zn2+ binding site [ion binding]; other site 1303024011405 short chain dehydrogenase; Validated; Region: PRK08264 1303024011406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024011407 NAD(P) binding site [chemical binding]; other site 1303024011408 active site 1303024011409 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1303024011410 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1303024011411 enoyl-CoA hydratase; Provisional; Region: PRK07509 1303024011412 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024011413 substrate binding site [chemical binding]; other site 1303024011414 oxyanion hole (OAH) forming residues; other site 1303024011415 trimer interface [polypeptide binding]; other site 1303024011416 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1303024011417 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1303024011418 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1303024011419 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1303024011420 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1303024011421 active site 1303024011422 ATP binding site [chemical binding]; other site 1303024011423 substrate binding site [chemical binding]; other site 1303024011424 activation loop (A-loop); other site 1303024011425 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1303024011426 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1303024011427 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1303024011428 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1303024011429 FAD binding site [chemical binding]; other site 1303024011430 substrate binding site [chemical binding]; other site 1303024011431 catalytic residues [active] 1303024011432 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1303024011433 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1303024011434 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024011435 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1303024011436 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1303024011437 AAA domain; Region: AAA_18; pfam13238 1303024011438 active site 1303024011439 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1303024011440 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1303024011441 Moco binding site; other site 1303024011442 metal coordination site [ion binding]; other site 1303024011443 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1303024011444 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1303024011445 dimer interface [polypeptide binding]; other site 1303024011446 active site 1303024011447 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1303024011448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024011449 NAD(P) binding site [chemical binding]; other site 1303024011450 active site 1303024011451 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024011452 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024011453 active site 2 [active] 1303024011454 active site 1 [active] 1303024011455 TIGR03086 family protein; Region: TIGR03086 1303024011456 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024011457 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1303024011458 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1303024011459 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1303024011460 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1303024011461 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1303024011462 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1303024011463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011465 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1303024011466 YCII-related domain; Region: YCII; cl00999 1303024011467 YCII-related domain; Region: YCII; cl00999 1303024011468 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1303024011469 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1303024011470 acyl-activating enzyme (AAE) consensus motif; other site 1303024011471 active site 1303024011472 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024011473 Cytochrome P450; Region: p450; cl12078 1303024011474 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024011475 Cytochrome P450; Region: p450; cl12078 1303024011476 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1303024011477 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1303024011478 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1303024011479 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1303024011480 Sulfatase; Region: Sulfatase; pfam00884 1303024011481 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1303024011482 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1303024011483 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1303024011484 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1303024011485 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1303024011486 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1303024011487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1303024011488 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1303024011489 dinuclear metal binding motif [ion binding]; other site 1303024011490 short chain dehydrogenase; Provisional; Region: PRK07832 1303024011491 classical (c) SDRs; Region: SDR_c; cd05233 1303024011492 NAD(P) binding site [chemical binding]; other site 1303024011493 active site 1303024011494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011495 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1303024011496 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1303024011497 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1303024011498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024011499 S-adenosylmethionine binding site [chemical binding]; other site 1303024011500 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1303024011501 putative active site [active] 1303024011502 putative substrate binding site [chemical binding]; other site 1303024011503 ATP binding site [chemical binding]; other site 1303024011504 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1303024011505 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024011506 NAD binding site [chemical binding]; other site 1303024011507 catalytic residues [active] 1303024011508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024011509 metabolite-proton symporter; Region: 2A0106; TIGR00883 1303024011510 putative substrate translocation pore; other site 1303024011511 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1303024011512 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1303024011513 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1303024011514 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1303024011515 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024011516 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024011517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024011518 active site 1303024011519 phosphorylation site [posttranslational modification] 1303024011520 intermolecular recognition site; other site 1303024011521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024011522 DNA binding residues [nucleotide binding] 1303024011523 dimerization interface [polypeptide binding]; other site 1303024011524 GAF domain; Region: GAF_3; pfam13492 1303024011525 Histidine kinase; Region: HisKA_3; pfam07730 1303024011526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024011527 ATP binding site [chemical binding]; other site 1303024011528 G-X-G motif; other site 1303024011529 Transcription factor WhiB; Region: Whib; pfam02467 1303024011530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024011531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024011532 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1303024011533 active site 1303024011534 substrate-binding site [chemical binding]; other site 1303024011535 metal-binding site [ion binding] 1303024011536 GTP binding site [chemical binding]; other site 1303024011537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024011538 S-adenosylmethionine binding site [chemical binding]; other site 1303024011539 LabA_like proteins; Region: LabA_like; cd06167 1303024011540 putative metal binding site [ion binding]; other site 1303024011541 MMPL family; Region: MMPL; pfam03176 1303024011542 MMPL family; Region: MMPL; pfam03176 1303024011543 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1303024011544 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1303024011545 Colicin D; Region: Colicin_D; pfam11429 1303024011546 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1303024011547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011549 WHG domain; Region: WHG; pfam13305 1303024011550 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011551 mce related protein; Region: MCE; pfam02470 1303024011552 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011553 mce related protein; Region: MCE; pfam02470 1303024011554 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1303024011555 mce related protein; Region: MCE; pfam02470 1303024011556 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011557 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011558 mce related protein; Region: MCE; pfam02470 1303024011559 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011560 mce related protein; Region: MCE; pfam02470 1303024011561 mce related protein; Region: MCE; pfam02470 1303024011562 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1303024011563 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1303024011564 Permease; Region: Permease; pfam02405 1303024011565 Permease; Region: Permease; pfam02405 1303024011566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1303024011567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024011568 active site 1303024011569 phosphorylation site [posttranslational modification] 1303024011570 intermolecular recognition site; other site 1303024011571 dimerization interface [polypeptide binding]; other site 1303024011572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1303024011573 DNA binding residues [nucleotide binding] 1303024011574 dimerization interface [polypeptide binding]; other site 1303024011575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024011576 ATP binding site [chemical binding]; other site 1303024011577 Mg2+ binding site [ion binding]; other site 1303024011578 G-X-G motif; other site 1303024011579 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1303024011580 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1303024011581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024011582 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024011583 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1303024011584 dimerization interface [polypeptide binding]; other site 1303024011585 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1303024011586 cyclase homology domain; Region: CHD; cd07302 1303024011587 nucleotidyl binding site; other site 1303024011588 metal binding site [ion binding]; metal-binding site 1303024011589 dimer interface [polypeptide binding]; other site 1303024011590 Predicted integral membrane protein [Function unknown]; Region: COG0392 1303024011591 YceI-like domain; Region: YceI; pfam04264 1303024011592 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1303024011593 MMPL family; Region: MMPL; pfam03176 1303024011594 MMPL family; Region: MMPL; pfam03176 1303024011595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024011596 salt bridge; other site 1303024011597 non-specific DNA binding site [nucleotide binding]; other site 1303024011598 sequence-specific DNA binding site [nucleotide binding]; other site 1303024011599 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1303024011600 hypothetical protein; Provisional; Region: PRK01346 1303024011601 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1303024011602 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1303024011603 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1303024011604 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1303024011605 active site 1303024011606 Zn binding site [ion binding]; other site 1303024011607 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1303024011608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1303024011609 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1303024011610 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1303024011611 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024011612 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024011613 active site 1303024011614 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1303024011615 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1303024011616 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1303024011617 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1303024011618 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1303024011619 carboxyltransferase (CT) interaction site; other site 1303024011620 biotinylation site [posttranslational modification]; other site 1303024011621 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1303024011622 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1303024011623 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1303024011624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011626 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1303024011627 putative homodimer interface [polypeptide binding]; other site 1303024011628 putative homotetramer interface [polypeptide binding]; other site 1303024011629 putative allosteric switch controlling residues; other site 1303024011630 putative metal binding site [ion binding]; other site 1303024011631 putative homodimer-homodimer interface [polypeptide binding]; other site 1303024011632 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1303024011633 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1303024011634 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1303024011635 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1303024011636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011638 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1303024011639 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1303024011640 NAD(P) binding site [chemical binding]; other site 1303024011641 catalytic residues [active] 1303024011642 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1303024011643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024011644 S-adenosylmethionine binding site [chemical binding]; other site 1303024011645 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1303024011646 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1303024011647 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1303024011648 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1303024011649 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1303024011650 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1303024011651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024011652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024011653 DNA binding residues [nucleotide binding] 1303024011654 SnoaL-like domain; Region: SnoaL_2; pfam12680 1303024011655 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1303024011656 Zn binding site [ion binding]; other site 1303024011657 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1303024011658 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1303024011659 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1303024011660 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024011661 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1303024011662 acyl-activating enzyme (AAE) consensus motif; other site 1303024011663 acyl-activating enzyme (AAE) consensus motif; other site 1303024011664 putative AMP binding site [chemical binding]; other site 1303024011665 putative active site [active] 1303024011666 putative CoA binding site [chemical binding]; other site 1303024011667 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1303024011668 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1303024011669 NAD binding site [chemical binding]; other site 1303024011670 catalytic Zn binding site [ion binding]; other site 1303024011671 substrate binding site [chemical binding]; other site 1303024011672 structural Zn binding site [ion binding]; other site 1303024011673 Pirin-related protein [General function prediction only]; Region: COG1741 1303024011674 Pirin; Region: Pirin; pfam02678 1303024011675 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1303024011676 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011677 mce related protein; Region: MCE; pfam02470 1303024011678 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011679 mce related protein; Region: MCE; pfam02470 1303024011680 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011681 mce related protein; Region: MCE; pfam02470 1303024011682 mce related protein; Region: MCE; pfam02470 1303024011683 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011684 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011685 mce related protein; Region: MCE; pfam02470 1303024011686 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1303024011687 mce related protein; Region: MCE; pfam02470 1303024011688 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1303024011689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024011690 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1303024011691 acyl-activating enzyme (AAE) consensus motif; other site 1303024011692 acyl-activating enzyme (AAE) consensus motif; other site 1303024011693 putative AMP binding site [chemical binding]; other site 1303024011694 putative active site [active] 1303024011695 putative CoA binding site [chemical binding]; other site 1303024011696 enoyl-CoA hydratase; Provisional; Region: PRK06688 1303024011697 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024011698 substrate binding site [chemical binding]; other site 1303024011699 oxyanion hole (OAH) forming residues; other site 1303024011700 trimer interface [polypeptide binding]; other site 1303024011701 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1303024011702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024011703 DNA-binding site [nucleotide binding]; DNA binding site 1303024011704 FCD domain; Region: FCD; pfam07729 1303024011705 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1303024011706 putative hydrophobic ligand binding site [chemical binding]; other site 1303024011707 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1303024011708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011710 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1303024011711 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1303024011712 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1303024011713 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1303024011714 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1303024011715 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1303024011716 ligand binding site [chemical binding]; other site 1303024011717 homodimer interface [polypeptide binding]; other site 1303024011718 NAD(P) binding site [chemical binding]; other site 1303024011719 trimer interface B [polypeptide binding]; other site 1303024011720 trimer interface A [polypeptide binding]; other site 1303024011721 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1303024011722 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1303024011723 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1303024011724 putative dimer interface [polypeptide binding]; other site 1303024011725 N-terminal domain interface [polypeptide binding]; other site 1303024011726 putative substrate binding pocket (H-site) [chemical binding]; other site 1303024011727 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024011728 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024011729 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024011730 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024011731 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024011732 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024011733 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024011734 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024011735 enoyl-CoA hydratase; Provisional; Region: PRK08252 1303024011736 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1303024011737 substrate binding site [chemical binding]; other site 1303024011738 oxyanion hole (OAH) forming residues; other site 1303024011739 trimer interface [polypeptide binding]; other site 1303024011740 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1303024011741 Phosphotransferase enzyme family; Region: APH; pfam01636 1303024011742 putative active site [active] 1303024011743 putative substrate binding site [chemical binding]; other site 1303024011744 ATP binding site [chemical binding]; other site 1303024011745 nucleoside transporter; Region: 2A0110; TIGR00889 1303024011746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1303024011747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024011748 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1303024011749 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1303024011750 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1303024011751 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011752 mce related protein; Region: MCE; pfam02470 1303024011753 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011754 mce related protein; Region: MCE; pfam02470 1303024011755 mce related protein; Region: MCE; pfam02470 1303024011756 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011757 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011758 mce related protein; Region: MCE; pfam02470 1303024011759 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1303024011760 mce related protein; Region: MCE; pfam02470 1303024011761 mce related protein; Region: MCE; pfam02470 1303024011762 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1303024011763 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1303024011764 Permease; Region: Permease; pfam02405 1303024011765 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1303024011766 Permease; Region: Permease; pfam02405 1303024011767 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1303024011768 putative active site [active] 1303024011769 putative catalytic site [active] 1303024011770 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1303024011771 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1303024011772 NAD(P) binding site [chemical binding]; other site 1303024011773 short chain dehydrogenase; Provisional; Region: PRK07791 1303024011774 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1303024011775 NAD binding site [chemical binding]; other site 1303024011776 homodimer interface [polypeptide binding]; other site 1303024011777 active site 1303024011778 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1303024011779 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1303024011780 NAD(P) binding site [chemical binding]; other site 1303024011781 catalytic residues [active] 1303024011782 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024011783 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024011784 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024011785 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1303024011786 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1303024011787 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1303024011788 dimer interface [polypeptide binding]; other site 1303024011789 active site 1303024011790 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024011791 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024011792 active site 1303024011793 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1303024011794 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1303024011795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011797 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1303024011798 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024011799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024011800 S-adenosylmethionine binding site [chemical binding]; other site 1303024011801 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024011802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024011803 putative substrate translocation pore; other site 1303024011804 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024011805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1303024011806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1303024011807 sequence-specific DNA binding site [nucleotide binding]; other site 1303024011808 salt bridge; other site 1303024011809 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1303024011810 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1303024011811 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1303024011812 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1303024011813 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1303024011814 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1303024011815 tetramer interface [polypeptide binding]; other site 1303024011816 active site 1303024011817 Mg2+/Mn2+ binding site [ion binding]; other site 1303024011818 citrate synthase; Provisional; Region: PRK14033 1303024011819 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1303024011820 dimer interface [polypeptide binding]; other site 1303024011821 active site 1303024011822 citrylCoA binding site [chemical binding]; other site 1303024011823 oxalacetate/citrate binding site [chemical binding]; other site 1303024011824 coenzyme A binding site [chemical binding]; other site 1303024011825 catalytic triad [active] 1303024011826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1303024011827 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1303024011828 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1303024011829 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1303024011830 THF binding site; other site 1303024011831 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1303024011832 substrate binding site [chemical binding]; other site 1303024011833 THF binding site; other site 1303024011834 zinc-binding site [ion binding]; other site 1303024011835 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1303024011836 CoenzymeA binding site [chemical binding]; other site 1303024011837 subunit interaction site [polypeptide binding]; other site 1303024011838 PHB binding site; other site 1303024011839 acyl-CoA synthetase; Validated; Region: PRK06188 1303024011840 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1303024011841 putative active site [active] 1303024011842 putative CoA binding site [chemical binding]; other site 1303024011843 putative AMP binding site [chemical binding]; other site 1303024011844 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1303024011845 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1303024011846 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1303024011847 active site 1303024011848 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1303024011849 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1303024011850 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1303024011851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024011852 putative DNA binding site [nucleotide binding]; other site 1303024011853 putative Zn2+ binding site [ion binding]; other site 1303024011854 short chain dehydrogenase; Provisional; Region: PRK07814 1303024011855 classical (c) SDRs; Region: SDR_c; cd05233 1303024011856 NAD(P) binding site [chemical binding]; other site 1303024011857 active site 1303024011858 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1303024011859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011861 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1303024011862 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1303024011863 putative active site [active] 1303024011864 putative FMN binding site [chemical binding]; other site 1303024011865 putative substrate binding site [chemical binding]; other site 1303024011866 putative catalytic residue [active] 1303024011867 Domain of unknown function (DUF385); Region: DUF385; cl04387 1303024011868 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1303024011869 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1303024011870 dimer interface [polypeptide binding]; other site 1303024011871 active site 1303024011872 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1303024011873 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1303024011874 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1303024011875 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1303024011876 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1303024011877 putative transporter; Provisional; Region: PRK10484 1303024011878 Na binding site [ion binding]; other site 1303024011879 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1303024011880 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1303024011881 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1303024011882 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1303024011883 catalytic residue [active] 1303024011884 putative amidase; Provisional; Region: PRK06169 1303024011885 Amidase; Region: Amidase; pfam01425 1303024011886 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1303024011887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1303024011888 DNA-binding site [nucleotide binding]; DNA binding site 1303024011889 FCD domain; Region: FCD; pfam07729 1303024011890 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1303024011891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024011894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011895 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1303024011896 hydrophobic ligand binding site; other site 1303024011897 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1303024011898 active site 1303024011899 catalytic residues [active] 1303024011900 metal binding site [ion binding]; metal-binding site 1303024011901 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1303024011902 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1303024011903 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1303024011904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024011905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024011906 DNA binding residues [nucleotide binding] 1303024011907 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1303024011908 iron-sulfur cluster [ion binding]; other site 1303024011909 [2Fe-2S] cluster binding site [ion binding]; other site 1303024011910 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1303024011911 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1303024011912 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1303024011913 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1303024011914 active site 1303024011915 metal binding site [ion binding]; metal-binding site 1303024011916 short chain dehydrogenase; Provisional; Region: PRK12744 1303024011917 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1303024011918 NADP binding site [chemical binding]; other site 1303024011919 homodimer interface [polypeptide binding]; other site 1303024011920 active site 1303024011921 substrate binding site [chemical binding]; other site 1303024011922 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024011923 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024011924 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1303024011925 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1303024011926 active site 1303024011927 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1303024011928 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1303024011929 CGNR zinc finger; Region: zf-CGNR; pfam11706 1303024011930 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1303024011931 classical (c) SDRs; Region: SDR_c; cd05233 1303024011932 NAD(P) binding site [chemical binding]; other site 1303024011933 active site 1303024011934 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 1303024011935 Amidohydrolase; Region: Amidohydro_2; pfam04909 1303024011936 active site 1303024011937 acyl-CoA synthetase; Validated; Region: PRK09192 1303024011938 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024011939 acyl-activating enzyme (AAE) consensus motif; other site 1303024011940 AMP binding site [chemical binding]; other site 1303024011941 active site 1303024011942 CoA binding site [chemical binding]; other site 1303024011943 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1303024011944 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1303024011945 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1303024011946 Walker A/P-loop; other site 1303024011947 ATP binding site [chemical binding]; other site 1303024011948 Q-loop/lid; other site 1303024011949 ABC transporter signature motif; other site 1303024011950 Walker B; other site 1303024011951 D-loop; other site 1303024011952 H-loop/switch region; other site 1303024011953 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1303024011954 FtsX-like permease family; Region: FtsX; pfam02687 1303024011955 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1303024011956 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1303024011957 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1303024011958 catalytic residue [active] 1303024011959 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1303024011960 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1303024011961 trimerization site [polypeptide binding]; other site 1303024011962 active site 1303024011963 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1303024011964 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1303024011965 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1303024011966 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1303024011967 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1303024011968 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024011969 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1303024011970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024011971 NAD(P) binding site [chemical binding]; other site 1303024011972 active site 1303024011973 NlpC/P60 family; Region: NLPC_P60; cl17555 1303024011974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011975 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1303024011976 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1303024011977 TDP-binding site; other site 1303024011978 homodimer interface [polypeptide binding]; other site 1303024011979 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1303024011980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024011981 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1303024011982 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1303024011983 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024011984 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1303024011985 acyl-activating enzyme (AAE) consensus motif; other site 1303024011986 AMP binding site [chemical binding]; other site 1303024011987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024011988 Condensation domain; Region: Condensation; pfam00668 1303024011989 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024011990 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024011991 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024011992 acyl-activating enzyme (AAE) consensus motif; other site 1303024011993 AMP binding site [chemical binding]; other site 1303024011994 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024011995 Condensation domain; Region: Condensation; pfam00668 1303024011996 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1303024011997 Condensation domain; Region: Condensation; pfam00668 1303024011998 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024011999 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024012000 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024012001 peptide synthase; Provisional; Region: PRK12316 1303024012002 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024012003 acyl-activating enzyme (AAE) consensus motif; other site 1303024012004 AMP binding site [chemical binding]; other site 1303024012005 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024012006 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1303024012007 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024012008 acyl-activating enzyme (AAE) consensus motif; other site 1303024012009 AMP binding site [chemical binding]; other site 1303024012010 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024012011 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024012012 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024012013 acyl-activating enzyme (AAE) consensus motif; other site 1303024012014 AMP binding site [chemical binding]; other site 1303024012015 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024012016 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1303024012017 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024012018 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024012019 acyl-activating enzyme (AAE) consensus motif; other site 1303024012020 AMP binding site [chemical binding]; other site 1303024012021 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024012022 Condensation domain; Region: Condensation; pfam00668 1303024012023 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024012024 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024012025 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024012026 acyl-activating enzyme (AAE) consensus motif; other site 1303024012027 AMP binding site [chemical binding]; other site 1303024012028 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024012029 Condensation domain; Region: Condensation; pfam00668 1303024012030 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024012031 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024012032 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1303024012033 acyl-activating enzyme (AAE) consensus motif; other site 1303024012034 AMP binding site [chemical binding]; other site 1303024012035 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024012036 Condensation domain; Region: Condensation; pfam00668 1303024012037 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1303024012038 Condensation domain; Region: Condensation; pfam00668 1303024012039 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1303024012040 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1303024012041 MbtH-like protein; Region: MbtH; pfam03621 1303024012042 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024012043 Cytochrome P450; Region: p450; cl12078 1303024012044 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1303024012045 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1303024012046 homodimer interface [polypeptide binding]; other site 1303024012047 active site 1303024012048 TDP-binding site; other site 1303024012049 acceptor substrate-binding pocket; other site 1303024012050 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1303024012051 TDP-binding site; other site 1303024012052 homodimer interface [polypeptide binding]; other site 1303024012053 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1303024012054 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1303024012055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024012056 S-adenosylmethionine binding site [chemical binding]; other site 1303024012057 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1303024012058 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1303024012059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1303024012060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024012061 S-adenosylmethionine binding site [chemical binding]; other site 1303024012062 Transport protein; Region: actII; TIGR00833 1303024012063 Transport protein; Region: actII; TIGR00833 1303024012064 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1303024012065 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024012066 Secretory lipase; Region: LIP; pfam03583 1303024012067 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1303024012068 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024012069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024012070 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024012071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024012072 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1303024012073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024012074 NAD(P) binding site [chemical binding]; other site 1303024012075 active site 1303024012076 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1303024012077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024012078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1303024012079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1303024012080 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1303024012081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024012082 acyl-activating enzyme (AAE) consensus motif; other site 1303024012083 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1303024012084 AMP binding site [chemical binding]; other site 1303024012085 active site 1303024012086 acyl-activating enzyme (AAE) consensus motif; other site 1303024012087 CoA binding site [chemical binding]; other site 1303024012088 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1303024012089 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1303024012090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024012091 NAD(P) binding site [chemical binding]; other site 1303024012092 active site 1303024012093 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024012094 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1303024012095 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1303024012096 potassium/proton antiporter; Reviewed; Region: PRK05326 1303024012097 TrkA-C domain; Region: TrkA_C; pfam02080 1303024012098 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1303024012099 TrkA-N domain; Region: TrkA_N; pfam02254 1303024012100 TrkA-C domain; Region: TrkA_C; pfam02080 1303024012101 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1303024012102 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1303024012103 DNA binding residues [nucleotide binding] 1303024012104 dimer interface [polypeptide binding]; other site 1303024012105 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1303024012106 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1303024012107 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1303024012108 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1303024012109 Restriction endonuclease; Region: Mrr_cat; pfam04471 1303024012110 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1303024012111 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1303024012112 putative DNA binding site [nucleotide binding]; other site 1303024012113 catalytic residue [active] 1303024012114 putative H2TH interface [polypeptide binding]; other site 1303024012115 putative catalytic residues [active] 1303024012116 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1303024012117 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1303024012118 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1303024012119 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1303024012120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024012121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024012122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1303024012123 dimerization interface [polypeptide binding]; other site 1303024012124 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1303024012125 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1303024012126 NAD binding site [chemical binding]; other site 1303024012127 catalytic Zn binding site [ion binding]; other site 1303024012128 substrate binding site [chemical binding]; other site 1303024012129 structural Zn binding site [ion binding]; other site 1303024012130 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1303024012131 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1303024012132 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1303024012133 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1303024012134 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1303024012135 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1303024012136 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1303024012137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024012138 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1303024012139 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012141 DoxX-like family; Region: DoxX_2; pfam13564 1303024012142 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1303024012143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024012144 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1303024012145 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1303024012146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1303024012147 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1303024012148 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1303024012149 dimerization interface [polypeptide binding]; other site 1303024012150 DPS ferroxidase diiron center [ion binding]; other site 1303024012151 ion pore; other site 1303024012152 Thioredoxin; Region: Thioredoxin_4; cl17273 1303024012153 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1303024012154 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1303024012155 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1303024012156 metal binding site [ion binding]; metal-binding site 1303024012157 putative dimer interface [polypeptide binding]; other site 1303024012158 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1303024012159 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1303024012160 active site 1303024012161 catalytic residues [active] 1303024012162 TQO small subunit DoxD; Region: DoxD; pfam04173 1303024012163 TQO small subunit DoxA; Region: DoxA; pfam07680 1303024012164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024012165 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024012166 S-adenosylmethionine binding site [chemical binding]; other site 1303024012167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1303024012168 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024012169 Transport protein; Region: actII; TIGR00833 1303024012170 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1303024012171 putative homotetramer interface [polypeptide binding]; other site 1303024012172 putative homodimer interface [polypeptide binding]; other site 1303024012173 putative allosteric switch controlling residues; other site 1303024012174 putative metal binding site [ion binding]; other site 1303024012175 putative homodimer-homodimer interface [polypeptide binding]; other site 1303024012176 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024012177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012179 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1303024012180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024012181 NAD(P) binding site [chemical binding]; other site 1303024012182 active site 1303024012183 hypothetical protein; Provisional; Region: PRK10279 1303024012184 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1303024012185 nucleophile elbow; other site 1303024012186 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1303024012187 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1303024012188 catalytic residues [active] 1303024012189 catalytic nucleophile [active] 1303024012190 Recombinase; Region: Recombinase; pfam07508 1303024012191 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1303024012192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1303024012193 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1303024012194 Walker A motif; other site 1303024012195 ATP binding site [chemical binding]; other site 1303024012196 Walker B motif; other site 1303024012197 arginine finger; other site 1303024012198 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 1303024012199 active site 1303024012200 catalytic triad [active] 1303024012201 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1303024012202 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1303024012203 putative transposase OrfB; Reviewed; Region: PHA02517 1303024012204 HTH-like domain; Region: HTH_21; pfam13276 1303024012205 Integrase core domain; Region: rve; pfam00665 1303024012206 Integrase core domain; Region: rve_3; pfam13683 1303024012207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1303024012208 Transposase; Region: HTH_Tnp_1; cl17663 1303024012209 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1303024012210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024012211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024012212 DNA binding residues [nucleotide binding] 1303024012213 Putative zinc-finger; Region: zf-HC2; pfam13490 1303024012214 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024012215 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1303024012216 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1303024012217 classical (c) SDRs; Region: SDR_c; cd05233 1303024012218 NAD(P) binding site [chemical binding]; other site 1303024012219 active site 1303024012220 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1303024012221 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1303024012222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024012223 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 1303024012224 active site 1303024012225 motif I; other site 1303024012226 motif II; other site 1303024012227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1303024012228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1303024012229 dimerization interface [polypeptide binding]; other site 1303024012230 putative DNA binding site [nucleotide binding]; other site 1303024012231 putative Zn2+ binding site [ion binding]; other site 1303024012232 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1303024012233 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1303024012234 FMN binding site [chemical binding]; other site 1303024012235 active site 1303024012236 substrate binding site [chemical binding]; other site 1303024012237 catalytic residue [active] 1303024012238 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1303024012239 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1303024012240 NAD(P) binding site [chemical binding]; other site 1303024012241 catalytic residues [active] 1303024012242 Protein of unknown function, DUF417; Region: DUF417; cl01162 1303024012243 Putative zinc-finger; Region: zf-HC2; pfam13490 1303024012244 Isochorismatase family; Region: Isochorismatase; pfam00857 1303024012245 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1303024012246 catalytic triad [active] 1303024012247 conserved cis-peptide bond; other site 1303024012248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012252 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1303024012253 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1303024012254 NADP binding site [chemical binding]; other site 1303024012255 dimer interface [polypeptide binding]; other site 1303024012256 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1303024012257 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1303024012258 putative NAD(P) binding site [chemical binding]; other site 1303024012259 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1303024012260 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1303024012261 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1303024012262 conserved cys residue [active] 1303024012263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1303024012264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024012265 hypothetical protein; Provisional; Region: PRK06185 1303024012266 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1303024012267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012269 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1303024012270 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1303024012271 active site 1303024012272 nucleophile elbow; other site 1303024012273 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1303024012274 FMN binding site [chemical binding]; other site 1303024012275 dimer interface [polypeptide binding]; other site 1303024012276 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1303024012277 Predicted membrane protein [Function unknown]; Region: COG1511 1303024012278 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1303024012279 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1303024012280 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1303024012281 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1303024012282 Transcription factor WhiB; Region: Whib; pfam02467 1303024012283 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024012284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012286 Cupin; Region: Cupin_1; smart00835 1303024012287 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1303024012288 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1303024012289 Transport protein; Region: actII; TIGR00833 1303024012290 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1303024012291 cyclase homology domain; Region: CHD; cd07302 1303024012292 nucleotidyl binding site; other site 1303024012293 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1303024012294 metal binding site [ion binding]; metal-binding site 1303024012295 dimer interface [polypeptide binding]; other site 1303024012296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012298 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1303024012299 heme binding pocket [chemical binding]; other site 1303024012300 heme ligand [chemical binding]; other site 1303024012301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1303024012302 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1303024012303 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1303024012304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024012307 S-adenosylmethionine binding site [chemical binding]; other site 1303024012308 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1303024012309 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1303024012310 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1303024012311 active site 1303024012312 catalytic site [active] 1303024012313 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1303024012314 active site 2 [active] 1303024012315 active site 1 [active] 1303024012316 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1303024012317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024012318 Walker A/P-loop; other site 1303024012319 ATP binding site [chemical binding]; other site 1303024012320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1303024012321 ATP binding site [chemical binding]; other site 1303024012322 Q-loop/lid; other site 1303024012323 Q-loop/lid; other site 1303024012324 ABC transporter signature motif; other site 1303024012325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024012326 Walker B; other site 1303024012327 D-loop; other site 1303024012328 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1303024012329 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1303024012330 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1303024012331 PPE family; Region: PPE; pfam00823 1303024012332 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1303024012333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012335 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1303024012336 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1303024012337 Alkylmercury lyase; Region: MerB; pfam03243 1303024012338 short chain dehydrogenase; Provisional; Region: PRK05866 1303024012339 classical (c) SDRs; Region: SDR_c; cd05233 1303024012340 NAD(P) binding site [chemical binding]; other site 1303024012341 active site 1303024012342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1303024012343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1303024012344 putative substrate translocation pore; other site 1303024012345 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1303024012346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1303024012347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1303024012348 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1303024012349 dimerization interface [polypeptide binding]; other site 1303024012350 substrate binding pocket [chemical binding]; other site 1303024012351 Esterase/lipase [General function prediction only]; Region: COG1647 1303024012352 short chain dehydrogenase; Provisional; Region: PRK12937 1303024012353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024012354 NAD(P) binding site [chemical binding]; other site 1303024012355 active site 1303024012356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024012357 NAD(P) binding site [chemical binding]; other site 1303024012358 active site 1303024012359 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1303024012360 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024012361 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1303024012362 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1303024012363 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1303024012364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024012365 S-adenosylmethionine binding site [chemical binding]; other site 1303024012366 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1303024012367 Beta-lactamase; Region: Beta-lactamase; pfam00144 1303024012368 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1303024012369 active site 1303024012370 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1303024012371 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1303024012372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1303024012373 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1303024012374 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1303024012375 Predicted esterase [General function prediction only]; Region: COG0627 1303024012376 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1303024012377 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 1303024012378 amidase catalytic site [active] 1303024012379 Zn binding residues [ion binding]; other site 1303024012380 substrate binding site [chemical binding]; other site 1303024012381 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1303024012382 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1303024012383 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1303024012384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1303024012385 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1303024012386 dimerization interface [polypeptide binding]; other site 1303024012387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1303024012388 dimer interface [polypeptide binding]; other site 1303024012389 phosphorylation site [posttranslational modification] 1303024012390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1303024012391 ATP binding site [chemical binding]; other site 1303024012392 Mg2+ binding site [ion binding]; other site 1303024012393 G-X-G motif; other site 1303024012394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1303024012395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1303024012396 active site 1303024012397 phosphorylation site [posttranslational modification] 1303024012398 intermolecular recognition site; other site 1303024012399 dimerization interface [polypeptide binding]; other site 1303024012400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1303024012401 DNA binding site [nucleotide binding] 1303024012402 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1303024012403 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1303024012404 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1303024012405 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024012406 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1303024012407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1303024012408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012410 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1303024012411 MarR family; Region: MarR_2; pfam12802 1303024012412 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1303024012413 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1303024012414 MarR family; Region: MarR; pfam01047 1303024012415 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1303024012416 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1303024012417 tetramer interface [polypeptide binding]; other site 1303024012418 active site 1303024012419 Mg2+/Mn2+ binding site [ion binding]; other site 1303024012420 isopropylmalate isomerase large subunit; Provisional; Region: PRK12466 1303024012421 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1303024012422 substrate binding site [chemical binding]; other site 1303024012423 ligand binding site [chemical binding]; other site 1303024012424 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1303024012425 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1303024012426 substrate binding site [chemical binding]; other site 1303024012427 Isochorismatase family; Region: Isochorismatase; pfam00857 1303024012428 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1303024012429 catalytic triad [active] 1303024012430 conserved cis-peptide bond; other site 1303024012431 replicative DNA helicase; Region: DnaB; TIGR00665 1303024012432 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1303024012433 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1303024012434 Walker A motif; other site 1303024012435 ATP binding site [chemical binding]; other site 1303024012436 Walker B motif; other site 1303024012437 DNA binding loops [nucleotide binding] 1303024012438 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1303024012439 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1303024012440 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1303024012441 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1303024012442 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1303024012443 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1303024012444 dimer interface [polypeptide binding]; other site 1303024012445 ssDNA binding site [nucleotide binding]; other site 1303024012446 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1303024012447 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1303024012448 Predicted integral membrane protein [Function unknown]; Region: COG5650 1303024012449 Transglycosylase; Region: Transgly; pfam00912 1303024012450 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1303024012451 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1303024012452 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1303024012453 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1303024012454 Predicted transcriptional regulators [Transcription]; Region: COG1695 1303024012455 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1303024012456 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1303024012457 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1303024012458 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1303024012459 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1303024012460 Methyl-coenzyme M reductase operon protein C; Region: MCR_C; cl01674 1303024012461 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1303024012462 Phosphotransferase enzyme family; Region: APH; pfam01636 1303024012463 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1303024012464 putative active site [active] 1303024012465 putative substrate binding site [chemical binding]; other site 1303024012466 ATP binding site [chemical binding]; other site 1303024012467 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1303024012468 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1303024012469 active site 1303024012470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012472 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1303024012473 classical (c) SDRs; Region: SDR_c; cd05233 1303024012474 NAD(P) binding site [chemical binding]; other site 1303024012475 active site 1303024012476 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024012477 PknH-like extracellular domain; Region: PknH_C; pfam14032 1303024012478 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1303024012479 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1303024012480 E3 interaction surface; other site 1303024012481 lipoyl attachment site [posttranslational modification]; other site 1303024012482 e3 binding domain; Region: E3_binding; pfam02817 1303024012483 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1303024012484 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1303024012485 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1303024012486 alpha subunit interface [polypeptide binding]; other site 1303024012487 TPP binding site [chemical binding]; other site 1303024012488 heterodimer interface [polypeptide binding]; other site 1303024012489 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1303024012490 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1303024012491 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1303024012492 tetramer interface [polypeptide binding]; other site 1303024012493 TPP-binding site [chemical binding]; other site 1303024012494 heterodimer interface [polypeptide binding]; other site 1303024012495 phosphorylation loop region [posttranslational modification] 1303024012496 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1303024012497 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1303024012498 AsnC family; Region: AsnC_trans_reg; pfam01037 1303024012499 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1303024012500 Predicted membrane protein [Function unknown]; Region: COG2311 1303024012501 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1303024012502 short chain dehydrogenase; Provisional; Region: PRK08219 1303024012503 classical (c) SDRs; Region: SDR_c; cd05233 1303024012504 NAD(P) binding site [chemical binding]; other site 1303024012505 active site 1303024012506 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1303024012507 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1303024012508 HIGH motif; other site 1303024012509 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1303024012510 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1303024012511 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1303024012512 active site 1303024012513 KMSKS motif; other site 1303024012514 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1303024012515 tRNA binding surface [nucleotide binding]; other site 1303024012516 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1303024012517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1303024012518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1303024012519 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 1303024012520 hypothetical protein; Validated; Region: PRK00228 1303024012521 H+ Antiporter protein; Region: 2A0121; TIGR00900 1303024012522 TIGR03084 family protein; Region: TIGR03084 1303024012523 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1303024012524 Wyosine base formation; Region: Wyosine_form; pfam08608 1303024012525 acyltransferase PapA5; Provisional; Region: PRK09294 1303024012526 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1303024012527 hypothetical protein; Provisional; Region: PRK10621 1303024012528 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1303024012529 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1303024012530 active site 1303024012531 NTP binding site [chemical binding]; other site 1303024012532 metal binding triad [ion binding]; metal-binding site 1303024012533 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1303024012534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1303024012535 Zn2+ binding site [ion binding]; other site 1303024012536 Mg2+ binding site [ion binding]; other site 1303024012537 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1303024012538 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1303024012539 active site 1303024012540 Ap6A binding site [chemical binding]; other site 1303024012541 nudix motif; other site 1303024012542 metal binding site [ion binding]; metal-binding site 1303024012543 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1303024012544 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1303024012545 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1303024012546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1303024012547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1303024012548 DNA binding residues [nucleotide binding] 1303024012549 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1303024012550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1303024012551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1303024012552 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1303024012553 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1303024012554 catalytic residues [active] 1303024012555 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1303024012556 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1303024012557 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1303024012558 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1303024012559 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1303024012560 active site 1303024012561 metal binding site [ion binding]; metal-binding site 1303024012562 Cytochrome P450; Region: p450; cl12078 1303024012563 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1303024012564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1303024012565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1303024012566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1303024012567 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1303024012568 ParB-like nuclease domain; Region: ParBc; pfam02195 1303024012569 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1303024012570 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024012571 P-loop; other site 1303024012572 Magnesium ion binding site [ion binding]; other site 1303024012573 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1303024012574 Magnesium ion binding site [ion binding]; other site 1303024012575 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1303024012576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1303024012577 S-adenosylmethionine binding site [chemical binding]; other site 1303024012578 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1303024012579 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1303024012580 G-X-X-G motif; other site 1303024012581 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1303024012582 RxxxH motif; other site 1303024012583 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1303024012584 Ribonuclease P; Region: Ribonuclease_P; cl00457