-- dump date 20140619_151015 -- class Genbank::misc_feature -- table misc_feature_note -- id note 572418000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 572418000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418000003 Walker A motif; other site 572418000004 ATP binding site [chemical binding]; other site 572418000005 Walker B motif; other site 572418000006 arginine finger; other site 572418000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 572418000008 DnaA box-binding interface [nucleotide binding]; other site 572418000011 DNA polymerase III subunit beta; Validated; Region: PRK07761 572418000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 572418000013 putative DNA binding surface [nucleotide binding]; other site 572418000014 dimer interface [polypeptide binding]; other site 572418000015 beta-clamp/clamp loader binding surface; other site 572418000016 beta-clamp/translesion DNA polymerase binding surface; other site 572418000017 recF protein; Region: recf; TIGR00611 572418000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 572418000019 Walker A/P-loop; other site 572418000020 ATP binding site [chemical binding]; other site 572418000021 Q-loop/lid; other site 572418000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418000023 ABC transporter signature motif; other site 572418000024 Walker B; other site 572418000025 D-loop; other site 572418000026 H-loop/switch region; other site 572418000030 hypothetical protein; Provisional; Region: PRK03195 572418000031 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 572418000032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418000033 Mg2+ binding site [ion binding]; other site 572418000034 G-X-G motif; other site 572418000035 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 572418000036 anchoring element; other site 572418000037 dimer interface [polypeptide binding]; other site 572418000038 ATP binding site [chemical binding]; other site 572418000039 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 572418000040 active site 572418000041 putative metal-binding site [ion binding]; other site 572418000042 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 572418000044 DNA gyrase subunit A; Validated; Region: PRK05560 572418000045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 572418000046 CAP-like domain; other site 572418000047 active site 572418000048 primary dimer interface [polypeptide binding]; other site 572418000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572418000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572418000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572418000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572418000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572418000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572418000056 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 572418000057 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 572418000058 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 572418000059 active site 572418000060 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 572418000061 putative septation inhibitor protein; Reviewed; Region: PRK00159 572418000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 572418000063 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 572418000064 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 572418000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 572418000066 glutamine binding [chemical binding]; other site 572418000067 catalytic triad [active] 572418000070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418000071 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418000072 active site 572418000073 ATP binding site [chemical binding]; other site 572418000074 substrate binding site [chemical binding]; other site 572418000075 activation loop (A-loop); other site 572418000076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 572418000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572418000078 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572418000079 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572418000080 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572418000083 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418000084 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418000085 active site 572418000086 ATP binding site [chemical binding]; other site 572418000087 substrate binding site [chemical binding]; other site 572418000088 activation loop (A-loop); other site 572418000090 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572418000091 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572418000092 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 572418000093 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 572418000094 active site 572418000095 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418000096 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418000097 phosphopeptide binding site; other site 572418000098 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 572418000099 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418000100 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418000101 phosphopeptide binding site; other site 572418000102 Nitronate monooxygenase; Region: NMO; pfam03060 572418000103 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 572418000104 FMN binding site [chemical binding]; other site 572418000105 substrate binding site [chemical binding]; other site 572418000106 putative catalytic residue [active] 572418000107 Transcription factor WhiB; Region: Whib; pfam02467 572418000108 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572418000109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418000110 non-specific DNA binding site [nucleotide binding]; other site 572418000111 salt bridge; other site 572418000112 sequence-specific DNA binding site [nucleotide binding]; other site 572418000113 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572418000114 NlpC/P60 family; Region: NLPC_P60; pfam00877 572418000115 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 572418000116 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 572418000117 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 572418000118 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 572418000119 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 572418000120 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 572418000121 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 572418000122 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 572418000123 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418000124 catalytic residue [active] 572418000126 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 572418000127 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 572418000128 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 572418000129 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418000130 acyl-activating enzyme (AAE) consensus motif; other site 572418000131 active site 572418000132 TIGR03084 family protein; Region: TIGR03084 572418000133 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 572418000134 Wyosine base formation; Region: Wyosine_form; pfam08608 572418000135 H+ Antiporter protein; Region: 2A0121; TIGR00900 572418000136 hypothetical protein; Validated; Region: PRK00228 572418000137 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 572418000138 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 572418000139 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572418000140 active site 572418000141 HIGH motif; other site 572418000142 nucleotide binding site [chemical binding]; other site 572418000143 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572418000144 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572418000145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572418000146 active site 572418000147 KMSKS motif; other site 572418000148 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 572418000149 tRNA binding surface [nucleotide binding]; other site 572418000151 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572418000152 MarR family; Region: MarR; pfam01047 572418000153 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572418000154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572418000155 DNA-binding site [nucleotide binding]; DNA binding site 572418000156 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 572418000157 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418000158 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418000159 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 572418000160 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 572418000161 Predicted transcriptional regulators [Transcription]; Region: COG1695 572418000162 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572418000163 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 572418000164 Transglycosylase; Region: Transgly; pfam00912 572418000165 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 572418000166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572418000167 Predicted integral membrane protein [Function unknown]; Region: COG5650 572418000168 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 572418000169 conserved cys residue [active] 572418000170 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 572418000172 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572418000173 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572418000174 dimer interface [polypeptide binding]; other site 572418000175 ssDNA binding site [nucleotide binding]; other site 572418000176 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572418000177 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 572418000178 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 572418000179 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 572418000180 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 572418000182 replicative DNA helicase; Validated; Region: PRK07773 572418000183 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 572418000184 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 572418000185 Walker A motif; other site 572418000186 ATP binding site [chemical binding]; other site 572418000187 Walker B motif; other site 572418000188 DNA binding loops [nucleotide binding] 572418000189 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572418000190 protein-splicing catalytic site; other site 572418000191 thioester formation/cholesterol transfer; other site 572418000192 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572418000193 protein-splicing catalytic site; other site 572418000194 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572418000196 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 572418000197 ADP-ribose binding site [chemical binding]; other site 572418000198 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 572418000199 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 572418000200 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418000201 FAD binding domain; Region: FAD_binding_4; pfam01565 572418000202 Berberine and berberine like; Region: BBE; pfam08031 572418000204 hypothetical protein; Provisional; Region: PRK12438 572418000205 hypothetical protein; Validated; Region: PRK00068 572418000206 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 572418000207 homotetrameric interface [polypeptide binding]; other site 572418000208 putative active site [active] 572418000209 metal binding site [ion binding]; metal-binding site 572418000210 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 572418000211 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 572418000212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000214 short chain dehydrogenase; Provisional; Region: PRK06197 572418000215 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 572418000216 putative NAD(P) binding site [chemical binding]; other site 572418000217 active site 572418000218 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 572418000219 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 572418000220 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 572418000221 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 572418000222 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 572418000223 dimer interface [polypeptide binding]; other site 572418000224 active site 572418000225 glycine-pyridoxal phosphate binding site [chemical binding]; other site 572418000226 folate binding site [chemical binding]; other site 572418000228 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 572418000229 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 572418000230 putative NTP binding site [chemical binding]; other site 572418000231 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572418000232 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572418000233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572418000234 Walker A/P-loop; other site 572418000235 ATP binding site [chemical binding]; other site 572418000236 Q-loop/lid; other site 572418000237 ABC transporter signature motif; other site 572418000238 Walker B; other site 572418000239 D-loop; other site 572418000240 H-loop/switch region; other site 572418000241 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418000242 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418000243 ligand binding site [chemical binding]; other site 572418000244 flexible hinge region; other site 572418000248 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 572418000249 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572418000250 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 572418000251 active site 572418000252 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 572418000253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418000254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418000255 homodimer interface [polypeptide binding]; other site 572418000256 catalytic residue [active] 572418000257 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418000258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000260 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 572418000261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418000262 dimerization interface [polypeptide binding]; other site 572418000263 putative DNA binding site [nucleotide binding]; other site 572418000264 putative Zn2+ binding site [ion binding]; other site 572418000265 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 572418000266 hydrogenase 4 subunit B; Validated; Region: PRK06521 572418000267 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572418000268 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 572418000269 NADH dehydrogenase; Region: NADHdh; cl00469 572418000270 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 572418000271 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572418000272 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 572418000273 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 572418000274 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 572418000275 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 572418000276 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 572418000277 putative hydrophobic ligand binding site [chemical binding]; other site 572418000278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418000279 S-adenosylmethionine binding site [chemical binding]; other site 572418000280 Predicted membrane protein [Function unknown]; Region: COG3305 572418000281 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 572418000282 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 572418000283 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572418000284 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572418000285 metal-binding site [ion binding] 572418000286 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418000287 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572418000290 Predicted integral membrane protein [Function unknown]; Region: COG5660 572418000291 Putative zinc-finger; Region: zf-HC2; pfam13490 572418000292 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418000293 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418000294 active site 572418000295 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418000296 PPE family; Region: PPE; pfam00823 572418000297 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 572418000298 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 572418000299 FcoT-like thioesterase domain; Region: FcoT; pfam10862 572418000300 acyl-CoA synthetase; Validated; Region: PRK05857 572418000301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418000302 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 572418000303 acyl-activating enzyme (AAE) consensus motif; other site 572418000304 acyl-activating enzyme (AAE) consensus motif; other site 572418000305 AMP binding site [chemical binding]; other site 572418000306 active site 572418000307 CoA binding site [chemical binding]; other site 572418000309 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572418000310 AMP-binding enzyme; Region: AMP-binding; pfam00501 572418000311 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418000312 acyl-activating enzyme (AAE) consensus motif; other site 572418000313 active site 572418000314 AMP binding site [chemical binding]; other site 572418000315 CoA binding site [chemical binding]; other site 572418000316 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572418000317 Condensation domain; Region: Condensation; pfam00668 572418000318 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 572418000319 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 572418000320 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 572418000321 acyl-activating enzyme (AAE) consensus motif; other site 572418000322 AMP binding site [chemical binding]; other site 572418000323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572418000324 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 572418000325 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 572418000326 putative NAD(P) binding site [chemical binding]; other site 572418000327 active site 572418000328 putative substrate binding site [chemical binding]; other site 572418000333 Predicted membrane protein [Function unknown]; Region: COG3336 572418000334 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572418000335 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 572418000336 metal-binding site [ion binding] 572418000337 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418000338 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572418000341 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418000342 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418000343 ligand binding site [chemical binding]; other site 572418000344 flexible hinge region; other site 572418000345 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 572418000346 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 572418000347 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 572418000348 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572418000349 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418000350 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 572418000351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418000352 motif II; other site 572418000353 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572418000355 PE family; Region: PE; pfam00934 572418000356 Rhomboid family; Region: Rhomboid; pfam01694 572418000357 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 572418000358 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 572418000359 active site 572418000360 catalytic triad [active] 572418000361 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572418000362 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 572418000363 NADP-binding site; other site 572418000364 homotetramer interface [polypeptide binding]; other site 572418000365 substrate binding site [chemical binding]; other site 572418000366 homodimer interface [polypeptide binding]; other site 572418000367 active site 572418000369 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 572418000370 dimer interface [polypeptide binding]; other site 572418000371 active site 572418000372 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 572418000373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418000374 active site 572418000375 motif I; other site 572418000376 motif II; other site 572418000379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572418000380 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 572418000381 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572418000382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572418000383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572418000384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 572418000385 dimerization interface [polypeptide binding]; other site 572418000387 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 572418000388 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572418000389 PYR/PP interface [polypeptide binding]; other site 572418000390 dimer interface [polypeptide binding]; other site 572418000391 TPP binding site [chemical binding]; other site 572418000392 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572418000393 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 572418000394 TPP-binding site; other site 572418000395 dimer interface [polypeptide binding]; other site 572418000396 acyl-CoA synthetase; Validated; Region: PRK05852 572418000397 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418000398 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 572418000399 acyl-activating enzyme (AAE) consensus motif; other site 572418000400 acyl-activating enzyme (AAE) consensus motif; other site 572418000401 putative AMP binding site [chemical binding]; other site 572418000402 putative active site [active] 572418000403 putative CoA binding site [chemical binding]; other site 572418000405 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 572418000406 elongation factor G; Reviewed; Region: PRK12740 572418000407 G1 box; other site 572418000408 putative GEF interaction site [polypeptide binding]; other site 572418000409 GTP/Mg2+ binding site [chemical binding]; other site 572418000410 Switch I region; other site 572418000411 G2 box; other site 572418000412 G3 box; other site 572418000413 Switch II region; other site 572418000414 G4 box; other site 572418000415 G5 box; other site 572418000416 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 572418000417 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 572418000418 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 572418000420 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 572418000421 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 572418000422 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572418000423 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572418000425 trehalose synthase; Region: treS_nterm; TIGR02456 572418000426 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 572418000427 active site 572418000428 catalytic site [active] 572418000429 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 572418000430 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 572418000431 Predicted membrane protein [Function unknown]; Region: COG3619 572418000432 Predicted esterase [General function prediction only]; Region: COG0627 572418000433 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 572418000434 putative active site [active] 572418000435 putative catalytic site [active] 572418000436 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418000437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418000438 active site 572418000439 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 572418000440 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418000442 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 572418000443 Coenzyme A binding pocket [chemical binding]; other site 572418000444 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418000445 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 572418000446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000448 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418000449 Cytochrome P450; Region: p450; cl12078 572418000452 methionine sulfoxide reductase A; Provisional; Region: PRK14054 572418000453 SnoaL-like domain; Region: SnoaL_2; pfam12680 572418000454 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 572418000455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418000456 NAD(P) binding site [chemical binding]; other site 572418000457 active site 572418000458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 572418000459 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 572418000460 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 572418000461 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572418000462 minor groove reading motif; other site 572418000463 helix-hairpin-helix signature motif; other site 572418000464 active site 572418000465 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 572418000466 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 572418000467 Cl- selectivity filter; other site 572418000468 Cl- binding residues [ion binding]; other site 572418000469 pore gating glutamate residue; other site 572418000470 dimer interface [polypeptide binding]; other site 572418000471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000473 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418000474 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418000475 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418000476 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418000477 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 572418000478 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 572418000479 NAD(P) binding site [chemical binding]; other site 572418000480 catalytic residues [active] 572418000483 short chain dehydrogenase; Provisional; Region: PRK07791 572418000484 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 572418000485 NAD binding site [chemical binding]; other site 572418000486 homodimer interface [polypeptide binding]; other site 572418000487 active site 572418000489 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572418000490 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 572418000491 NAD(P) binding site [chemical binding]; other site 572418000493 PE family; Region: PE; pfam00934 572418000494 PE-PPE domain; Region: PE-PPE; pfam08237 572418000495 PE-PPE domain; Region: PE-PPE; pfam08237 572418000496 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 572418000497 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 572418000498 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 572418000499 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 572418000500 FAD binding site [chemical binding]; other site 572418000501 substrate binding site [chemical binding]; other site 572418000502 catalytic base [active] 572418000503 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 572418000504 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 572418000505 ligand binding site [chemical binding]; other site 572418000506 homodimer interface [polypeptide binding]; other site 572418000507 NAD(P) binding site [chemical binding]; other site 572418000508 trimer interface B [polypeptide binding]; other site 572418000509 trimer interface A [polypeptide binding]; other site 572418000510 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 572418000511 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 572418000512 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 572418000513 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 572418000514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000516 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 572418000517 PE family; Region: PE; pfam00934 572418000518 PE-PPE domain; Region: PE-PPE; pfam08237 572418000519 PE family; Region: PE; pfam00934 572418000520 PE-PPE domain; Region: PE-PPE; pfam08237 572418000521 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418000522 FAD binding domain; Region: FAD_binding_4; pfam01565 572418000523 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 572418000524 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572418000525 NAD(P) binding site [chemical binding]; other site 572418000527 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 572418000528 active site 572418000529 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 572418000530 putative hydrophobic ligand binding site [chemical binding]; other site 572418000531 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 572418000532 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418000533 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 572418000534 acyl-activating enzyme (AAE) consensus motif; other site 572418000535 acyl-activating enzyme (AAE) consensus motif; other site 572418000536 putative AMP binding site [chemical binding]; other site 572418000537 putative active site [active] 572418000538 putative CoA binding site [chemical binding]; other site 572418000540 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 572418000541 Permease; Region: Permease; pfam02405 572418000542 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 572418000543 Permease; Region: Permease; pfam02405 572418000544 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418000545 mce related protein; Region: MCE; pfam02470 572418000546 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 572418000547 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418000548 mce related protein; Region: MCE; pfam02470 572418000549 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 572418000550 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418000551 mce related protein; Region: MCE; pfam02470 572418000552 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418000553 mce related protein; Region: MCE; pfam02470 572418000554 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418000555 mce related protein; Region: MCE; pfam02470 572418000557 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418000558 mce related protein; Region: MCE; pfam02470 572418000559 RDD family; Region: RDD; pfam06271 572418000560 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 572418000562 Predicted membrane protein [Function unknown]; Region: COG1511 572418000563 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 572418000564 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 572418000565 Pirin-related protein [General function prediction only]; Region: COG1741 572418000566 Pirin; Region: Pirin; pfam02678 572418000567 RNA polymerase factor sigma-70; Validated; Region: PRK08241 572418000568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418000569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418000570 DNA binding residues [nucleotide binding] 572418000571 SnoaL-like domain; Region: SnoaL_2; pfam12680 572418000573 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 572418000574 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572418000575 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 572418000576 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 572418000579 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 572418000580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418000581 S-adenosylmethionine binding site [chemical binding]; other site 572418000582 SPW repeat; Region: SPW; pfam03779 572418000583 SPW repeat; Region: SPW; pfam03779 572418000584 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 572418000585 6-phosphogluconate dehydratase; Region: edd; TIGR01196 572418000587 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 572418000588 putative homodimer interface [polypeptide binding]; other site 572418000589 putative homotetramer interface [polypeptide binding]; other site 572418000590 putative allosteric switch controlling residues; other site 572418000591 putative metal binding site [ion binding]; other site 572418000592 putative homodimer-homodimer interface [polypeptide binding]; other site 572418000593 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 572418000594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418000595 putative substrate translocation pore; other site 572418000596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572418000597 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 572418000598 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572418000599 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572418000600 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572418000601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418000602 Walker A/P-loop; other site 572418000603 ATP binding site [chemical binding]; other site 572418000604 Q-loop/lid; other site 572418000605 ABC transporter signature motif; other site 572418000606 Walker B; other site 572418000607 D-loop; other site 572418000608 H-loop/switch region; other site 572418000609 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572418000610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418000611 Walker A/P-loop; other site 572418000612 ATP binding site [chemical binding]; other site 572418000613 Q-loop/lid; other site 572418000614 ABC transporter signature motif; other site 572418000615 Walker B; other site 572418000616 D-loop; other site 572418000617 H-loop/switch region; other site 572418000621 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572418000622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572418000623 dimerization interface [polypeptide binding]; other site 572418000624 DNA binding residues [nucleotide binding] 572418000625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000628 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 572418000629 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 572418000630 active site 572418000631 Zn binding site [ion binding]; other site 572418000633 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418000634 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 572418000635 Predicted integral membrane protein [Function unknown]; Region: COG0392 572418000636 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 572418000637 Domain of unknown function DUF20; Region: UPF0118; pfam01594 572418000638 MMPL family; Region: MMPL; pfam03176 572418000639 MMPL family; Region: MMPL; pfam03176 572418000640 LabA_like proteins; Region: LabA_like; cd06167 572418000641 putative metal binding site [ion binding]; other site 572418000642 Putative methyltransferase; Region: Methyltransf_4; pfam02390 572418000643 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 572418000644 active site 572418000645 substrate-binding site [chemical binding]; other site 572418000646 metal-binding site [ion binding] 572418000647 GTP binding site [chemical binding]; other site 572418000649 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 572418000650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572418000651 active site 572418000652 nucleotide binding site [chemical binding]; other site 572418000653 HIGH motif; other site 572418000654 KMSKS motif; other site 572418000655 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 572418000657 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 572418000658 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 572418000659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418000660 FeS/SAM binding site; other site 572418000661 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 572418000662 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418000663 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 572418000664 acyl-activating enzyme (AAE) consensus motif; other site 572418000665 acyl-activating enzyme (AAE) consensus motif; other site 572418000666 putative AMP binding site [chemical binding]; other site 572418000667 putative active site [active] 572418000668 putative CoA binding site [chemical binding]; other site 572418000670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418000671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418000672 active site 572418000673 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 572418000674 putative active site [active] 572418000675 putative catalytic site [active] 572418000676 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 572418000677 active site 2 [active] 572418000678 active site 1 [active] 572418000679 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418000680 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418000681 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 572418000682 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 572418000683 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 572418000684 Moco binding site; other site 572418000685 metal coordination site [ion binding]; other site 572418000686 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418000687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572418000693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418000694 S-adenosylmethionine binding site [chemical binding]; other site 572418000695 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572418000696 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572418000697 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 572418000698 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 572418000699 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 572418000700 putative active site [active] 572418000702 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 572418000703 active site 572418000704 substrate binding pocket [chemical binding]; other site 572418000705 homodimer interaction site [polypeptide binding]; other site 572418000706 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418000707 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 572418000708 active site 572418000709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000712 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 572418000713 active site 572418000714 diiron metal binding site [ion binding]; other site 572418000715 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 572418000716 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 572418000717 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 572418000718 NAD(P) binding site [chemical binding]; other site 572418000719 catalytic residues [active] 572418000721 Lipase maturation factor; Region: LMF1; pfam06762 572418000722 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 572418000723 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 572418000724 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 572418000725 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 572418000727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000729 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418000730 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 572418000731 MaoC like domain; Region: MaoC_dehydratas; pfam01575 572418000732 active site 2 [active] 572418000733 active site 1 [active] 572418000734 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 572418000735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418000736 NAD(P) binding site [chemical binding]; other site 572418000737 active site 572418000739 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 572418000740 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572418000741 dimer interface [polypeptide binding]; other site 572418000742 active site 572418000744 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 572418000745 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 572418000746 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 572418000747 FAD binding site [chemical binding]; other site 572418000748 substrate binding site [chemical binding]; other site 572418000749 catalytic residues [active] 572418000750 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 572418000751 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 572418000752 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 572418000753 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572418000754 catalytic loop [active] 572418000755 iron binding site [ion binding]; other site 572418000757 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 572418000758 L-aspartate oxidase; Provisional; Region: PRK06175 572418000759 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572418000762 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 572418000763 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 572418000764 putative dimer interface [polypeptide binding]; other site 572418000765 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 572418000766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418000767 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 572418000768 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572418000770 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 572418000771 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 572418000772 homotrimer interface [polypeptide binding]; other site 572418000773 Walker A motif; other site 572418000774 GTP binding site [chemical binding]; other site 572418000775 Walker B motif; other site 572418000777 cobyric acid synthase; Provisional; Region: PRK00784 572418000778 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 572418000779 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 572418000780 catalytic triad [active] 572418000781 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418000782 PPE family; Region: PPE; pfam00823 572418000784 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 572418000785 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 572418000786 putative active site [active] 572418000787 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 572418000788 putative active site [active] 572418000789 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 572418000790 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 572418000791 active site 572418000792 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 572418000793 DNA binding site [nucleotide binding] 572418000794 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 572418000795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418000796 Coenzyme A binding pocket [chemical binding]; other site 572418000797 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 572418000798 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 572418000799 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 572418000800 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 572418000801 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 572418000802 intersubunit interface [polypeptide binding]; other site 572418000804 5-oxoprolinase; Region: PLN02666 572418000805 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 572418000806 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 572418000807 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 572418000809 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 572418000810 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 572418000811 nucleotide binding site [chemical binding]; other site 572418000812 acyl-CoA synthetase; Validated; Region: PRK07788 572418000813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418000814 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418000815 active site 572418000816 CoA binding site [chemical binding]; other site 572418000817 AMP binding site [chemical binding]; other site 572418000819 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418000820 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418000821 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 572418000822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418000823 FAD binding site [chemical binding]; other site 572418000824 substrate binding site [chemical binding]; other site 572418000825 catalytic base [active] 572418000826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572418000827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000829 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 572418000830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418000831 Zn binding site [ion binding]; other site 572418000833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 572418000834 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418000835 putative active site [active] 572418000838 PE family; Region: PE; pfam00934 572418000839 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418000840 PPE family; Region: PPE; pfam00823 572418000841 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418000842 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418000843 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418000844 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 572418000845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418000846 Walker A motif; other site 572418000847 ATP binding site [chemical binding]; other site 572418000848 Walker B motif; other site 572418000849 arginine finger; other site 572418000851 Protein of unknown function (DUF690); Region: DUF690; pfam05108 572418000853 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 572418000854 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418000855 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 572418000856 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418000857 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418000861 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418000862 PPE family; Region: PPE; pfam00823 572418000863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 572418000864 EspG family; Region: ESX-1_EspG; pfam14011 572418000865 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 572418000866 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 572418000867 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 572418000868 active site 572418000869 catalytic residues [active] 572418000871 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 572418000872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572418000873 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 572418000874 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 572418000875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418000876 S-adenosylmethionine binding site [chemical binding]; other site 572418000877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 572418000878 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 572418000879 Sulfatase; Region: Sulfatase; cl17466 572418000881 hypothetical protein; Region: PHA01748 572418000882 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 572418000883 putative active site [active] 572418000884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000886 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 572418000887 protochlorophyllide reductase; Region: PLN00015 572418000888 putative NAD(P) binding site [chemical binding]; other site 572418000889 active site 572418000891 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418000892 PPE family; Region: PPE; pfam00823 572418000893 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418000894 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418000895 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418000896 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418000897 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418000898 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418000899 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418000900 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418000901 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 572418000902 putative FMN binding site [chemical binding]; other site 572418000903 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 572418000904 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 572418000905 active site 572418000906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 572418000907 SnoaL-like domain; Region: SnoaL_4; pfam13577 572418000908 SnoaL-like domain; Region: SnoaL_3; pfam13474 572418000909 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 572418000910 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572418000911 nucleotide binding site [chemical binding]; other site 572418000912 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 572418000913 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 572418000914 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 572418000915 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 572418000916 active site 572418000917 catalytic residues [active] 572418000919 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 572418000920 Muconolactone delta-isomerase; Region: MIase; cl01992 572418000921 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 572418000922 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 572418000923 putative active site [active] 572418000924 catalytic site [active] 572418000925 putative metal binding site [ion binding]; other site 572418000926 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 572418000927 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 572418000928 putative substrate binding pocket [chemical binding]; other site 572418000929 AC domain interface; other site 572418000930 catalytic triad [active] 572418000931 AB domain interface; other site 572418000932 interchain disulfide; other site 572418000933 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 572418000934 trimer interface [polypeptide binding]; other site 572418000935 active site 572418000937 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 572418000938 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 572418000939 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 572418000940 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 572418000942 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 572418000943 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418000944 dimerization interface [polypeptide binding]; other site 572418000945 putative DNA binding site [nucleotide binding]; other site 572418000946 putative Zn2+ binding site [ion binding]; other site 572418000947 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572418000948 active site residue [active] 572418000949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418000950 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418000951 Cytochrome P450; Region: p450; cl12078 572418000953 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 572418000954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000955 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 572418000957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418000958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418000959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 572418000960 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 572418000961 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 572418000962 SnoaL-like domain; Region: SnoaL_2; pfam12680 572418000963 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 572418000964 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 572418000965 substrate binding site; other site 572418000966 tetramer interface; other site 572418000967 PE family; Region: PE; pfam00934 572418000969 aminotransferase AlaT; Validated; Region: PRK09265 572418000970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418000971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418000972 homodimer interface [polypeptide binding]; other site 572418000973 catalytic residue [active] 572418000974 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 572418000975 4Fe-4S binding domain; Region: Fer4; pfam00037 572418000976 Cysteine-rich domain; Region: CCG; pfam02754 572418000977 Cysteine-rich domain; Region: CCG; pfam02754 572418000981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572418000982 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572418000983 DNA binding residues [nucleotide binding] 572418000984 dimerization interface [polypeptide binding]; other site 572418000987 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 572418000988 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572418000989 G1 box; other site 572418000990 GTP/Mg2+ binding site [chemical binding]; other site 572418000991 G2 box; other site 572418000992 Switch I region; other site 572418000993 G3 box; other site 572418000994 Switch II region; other site 572418000997 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 572418000998 active site 572418000999 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 572418001000 TIGR04255 family protein; Region: sporadTIGR04255 572418001001 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 572418001002 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 572418001003 nucleotide binding site [chemical binding]; other site 572418001004 NEF interaction site [polypeptide binding]; other site 572418001005 SBD interface [polypeptide binding]; other site 572418001006 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 572418001007 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 572418001008 dimer interface [polypeptide binding]; other site 572418001009 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 572418001011 chaperone protein DnaJ; Provisional; Region: PRK14279 572418001012 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 572418001013 HSP70 interaction site [polypeptide binding]; other site 572418001014 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 572418001015 Zn binding sites [ion binding]; other site 572418001016 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 572418001017 dimer interface [polypeptide binding]; other site 572418001020 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 572418001021 DNA binding residues [nucleotide binding] 572418001022 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572418001023 putative dimer interface [polypeptide binding]; other site 572418001025 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 572418001026 CoenzymeA binding site [chemical binding]; other site 572418001027 subunit interaction site [polypeptide binding]; other site 572418001028 PHB binding site; other site 572418001029 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 572418001030 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 572418001031 GDP-binding site [chemical binding]; other site 572418001032 ACT binding site; other site 572418001033 IMP binding site; other site 572418001034 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 572418001035 Peptidase family M50; Region: Peptidase_M50; pfam02163 572418001036 active site 572418001037 putative substrate binding region [chemical binding]; other site 572418001039 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 572418001040 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 572418001041 MgtE intracellular N domain; Region: MgtE_N; pfam03448 572418001042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 572418001043 Divalent cation transporter; Region: MgtE; pfam01769 572418001044 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 572418001045 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 572418001046 active site 572418001047 intersubunit interface [polypeptide binding]; other site 572418001048 zinc binding site [ion binding]; other site 572418001049 Na+ binding site [ion binding]; other site 572418001050 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572418001051 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 572418001052 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 572418001053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 572418001054 AAA domain; Region: AAA_33; pfam13671 572418001057 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 572418001058 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 572418001059 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 572418001060 metal ion-dependent adhesion site (MIDAS); other site 572418001062 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 572418001063 putative hydrophobic ligand binding site [chemical binding]; other site 572418001064 MoxR-like ATPases [General function prediction only]; Region: COG0714 572418001066 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 572418001067 Ligand binding site; other site 572418001068 metal-binding site 572418001069 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 572418001070 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 572418001071 XdhC Rossmann domain; Region: XdhC_C; pfam13478 572418001072 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 572418001073 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 572418001074 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 572418001075 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 572418001076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572418001077 catalytic loop [active] 572418001078 iron binding site [ion binding]; other site 572418001079 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 572418001080 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 572418001081 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 572418001082 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 572418001083 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 572418001084 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 572418001085 XdhC Rossmann domain; Region: XdhC_C; pfam13478 572418001086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572418001087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572418001088 LysR substrate binding domain; Region: LysR_substrate; pfam03466 572418001089 dimerization interface [polypeptide binding]; other site 572418001091 Uncharacterized conserved protein [Function unknown]; Region: COG3360 572418001092 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 572418001093 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572418001094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418001095 active site 572418001097 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 572418001098 Clp amino terminal domain; Region: Clp_N; pfam02861 572418001099 Clp amino terminal domain; Region: Clp_N; pfam02861 572418001100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418001101 Walker A motif; other site 572418001102 ATP binding site [chemical binding]; other site 572418001103 Walker B motif; other site 572418001104 arginine finger; other site 572418001105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418001106 Walker A motif; other site 572418001107 ATP binding site [chemical binding]; other site 572418001108 Walker B motif; other site 572418001109 arginine finger; other site 572418001110 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 572418001115 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 572418001116 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 572418001117 heme-binding site [chemical binding]; other site 572418001118 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 572418001119 FAD binding pocket [chemical binding]; other site 572418001120 FAD binding motif [chemical binding]; other site 572418001121 phosphate binding motif [ion binding]; other site 572418001122 beta-alpha-beta structure motif; other site 572418001123 NAD binding pocket [chemical binding]; other site 572418001127 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418001128 PPE family; Region: PPE; pfam00823 572418001129 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 572418001130 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 572418001131 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572418001132 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 572418001133 active site residue [active] 572418001134 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 572418001135 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572418001136 homodimer interface [polypeptide binding]; other site 572418001137 substrate-cofactor binding pocket; other site 572418001138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418001139 catalytic residue [active] 572418001140 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 572418001141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418001142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418001143 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418001144 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418001145 active site 572418001146 PLD-like domain; Region: PLDc_2; pfam13091 572418001147 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418001148 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418001149 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 572418001150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418001151 FAD binding site [chemical binding]; other site 572418001152 substrate binding pocket [chemical binding]; other site 572418001153 catalytic base [active] 572418001154 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 572418001155 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418001156 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 572418001157 acyl-CoA synthetase; Validated; Region: PRK05850 572418001158 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418001159 acyl-activating enzyme (AAE) consensus motif; other site 572418001160 active site 572418001161 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 572418001162 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418001163 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 572418001164 active site 572418001165 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572418001166 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418001167 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418001168 Thioesterase; Region: PKS_TE; smart00824 572418001173 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572418001174 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 572418001175 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 572418001176 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418001177 phosphate acetyltransferase; Reviewed; Region: PRK05632 572418001178 DRTGG domain; Region: DRTGG; pfam07085 572418001179 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 572418001180 propionate/acetate kinase; Provisional; Region: PRK12379 572418001181 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 572418001184 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418001185 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418001186 active site 572418001187 ATP binding site [chemical binding]; other site 572418001188 substrate binding site [chemical binding]; other site 572418001189 activation loop (A-loop); other site 572418001191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572418001192 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 572418001193 substrate binding pocket [chemical binding]; other site 572418001194 membrane-bound complex binding site; other site 572418001195 hinge residues; other site 572418001198 NUDIX domain; Region: NUDIX; pfam00293 572418001199 nudix motif; other site 572418001200 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 572418001201 thiamine phosphate binding site [chemical binding]; other site 572418001202 active site 572418001203 pyrophosphate binding site [ion binding]; other site 572418001204 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 572418001205 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 572418001206 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 572418001207 thiS-thiF/thiG interaction site; other site 572418001208 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 572418001209 ThiS interaction site; other site 572418001210 putative active site [active] 572418001211 tetramer interface [polypeptide binding]; other site 572418001212 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 572418001213 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 572418001214 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 572418001215 PA/protease or protease-like domain interface [polypeptide binding]; other site 572418001216 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 572418001217 active site 572418001218 metal binding site [ion binding]; metal-binding site 572418001220 Predicted metalloprotease [General function prediction only]; Region: COG2321 572418001221 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 572418001222 Zn binding site [ion binding]; other site 572418001225 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572418001226 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 572418001227 dimer interface [polypeptide binding]; other site 572418001228 substrate binding site [chemical binding]; other site 572418001229 ATP binding site [chemical binding]; other site 572418001230 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 572418001231 ThiC-associated domain; Region: ThiC-associated; pfam13667 572418001232 ThiC family; Region: ThiC; pfam01964 572418001233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418001234 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 572418001235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418001236 motif II; other site 572418001237 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572418001238 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 572418001239 putative catalytic site [active] 572418001240 putative phosphate binding site [ion binding]; other site 572418001241 active site 572418001242 metal binding site A [ion binding]; metal-binding site 572418001243 DNA binding site [nucleotide binding] 572418001244 putative AP binding site [nucleotide binding]; other site 572418001245 putative metal binding site B [ion binding]; other site 572418001246 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 572418001247 active site 572418001248 catalytic residues [active] 572418001249 metal binding site [ion binding]; metal-binding site 572418001250 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 572418001251 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 572418001252 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 572418001253 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 572418001254 E-class dimer interface [polypeptide binding]; other site 572418001255 P-class dimer interface [polypeptide binding]; other site 572418001256 active site 572418001257 Cu2+ binding site [ion binding]; other site 572418001258 Zn2+ binding site [ion binding]; other site 572418001260 carboxylate-amine ligase; Provisional; Region: PRK13517 572418001261 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 572418001262 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 572418001263 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 572418001264 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 572418001265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418001266 Walker A motif; other site 572418001267 ATP binding site [chemical binding]; other site 572418001268 Walker B motif; other site 572418001269 arginine finger; other site 572418001270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418001271 Walker A motif; other site 572418001272 ATP binding site [chemical binding]; other site 572418001273 Walker B motif; other site 572418001274 arginine finger; other site 572418001277 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 572418001278 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 572418001280 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 572418001281 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 572418001282 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 572418001283 dimer interface [polypeptide binding]; other site 572418001284 putative functional site; other site 572418001285 putative MPT binding site; other site 572418001286 short chain dehydrogenase; Provisional; Region: PRK06197 572418001287 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 572418001288 putative NAD(P) binding site [chemical binding]; other site 572418001289 active site 572418001290 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 572418001291 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 572418001292 ring oligomerisation interface [polypeptide binding]; other site 572418001293 ATP/Mg binding site [chemical binding]; other site 572418001294 stacking interactions; other site 572418001295 hinge regions; other site 572418001298 Protein of unknown function (DUF664); Region: DUF664; pfam04978 572418001299 DinB superfamily; Region: DinB_2; pfam12867 572418001300 putative anti-sigmaE protein; Provisional; Region: PRK13920 572418001301 Anti-sigma-K factor rskA; Region: RskA; pfam10099 572418001302 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 572418001303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418001304 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418001305 DNA binding residues [nucleotide binding] 572418001306 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 572418001307 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001309 S-adenosylmethionine binding site [chemical binding]; other site 572418001310 Uncharacterized conserved protein [Function unknown]; Region: COG3496 572418001311 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 572418001312 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 572418001313 dimer interface [polypeptide binding]; other site 572418001314 Transport protein; Region: actII; TIGR00833 572418001316 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 572418001317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418001318 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418001319 PPE family; Region: PPE; pfam00823 572418001320 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418001321 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 572418001322 enoyl-CoA hydratase; Provisional; Region: PRK12478 572418001323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418001324 substrate binding site [chemical binding]; other site 572418001325 oxyanion hole (OAH) forming residues; other site 572418001326 trimer interface [polypeptide binding]; other site 572418001327 PemK-like protein; Region: PemK; pfam02452 572418001328 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 572418001329 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572418001330 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 572418001331 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 572418001332 NAD(P) binding site [chemical binding]; other site 572418001333 catalytic residues [active] 572418001334 Protein of unknown function (DUF779); Region: DUF779; cl01432 572418001335 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 572418001336 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 572418001337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418001338 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572418001339 Uncharacterized conserved protein [Function unknown]; Region: COG2128 572418001340 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 572418001341 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572418001342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418001343 non-specific DNA binding site [nucleotide binding]; other site 572418001344 salt bridge; other site 572418001345 sequence-specific DNA binding site [nucleotide binding]; other site 572418001346 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 572418001347 Domain of unknown function (DUF955); Region: DUF955; pfam06114 572418001348 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 572418001349 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 572418001350 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 572418001351 active site 572418001352 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 572418001353 active site 2 [active] 572418001354 isocitrate lyase; Provisional; Region: PRK15063 572418001355 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 572418001356 oligomerization interface [polypeptide binding]; other site 572418001357 active site 572418001358 metal binding site [ion binding]; metal-binding site 572418001359 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 572418001360 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 572418001361 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 572418001362 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418001363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001364 S-adenosylmethionine binding site [chemical binding]; other site 572418001365 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418001366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572418001367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001368 S-adenosylmethionine binding site [chemical binding]; other site 572418001369 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 572418001370 UbiA prenyltransferase family; Region: UbiA; pfam01040 572418001371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418001372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418001373 Predicted membrane protein [Function unknown]; Region: COG2733 572418001374 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572418001375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418001376 non-specific DNA binding site [nucleotide binding]; other site 572418001377 salt bridge; other site 572418001378 sequence-specific DNA binding site [nucleotide binding]; other site 572418001379 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 572418001381 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 572418001382 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 572418001383 intersubunit interface [polypeptide binding]; other site 572418001384 active site 572418001385 catalytic residue [active] 572418001386 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 572418001387 Predicted amidohydrolase [General function prediction only]; Region: COG0388 572418001388 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 572418001389 putative active site [active] 572418001390 catalytic triad [active] 572418001391 putative dimer interface [polypeptide binding]; other site 572418001392 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 572418001393 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 572418001394 FAD binding domain; Region: FAD_binding_4; pfam01565 572418001395 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 572418001396 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 572418001397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572418001398 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 572418001399 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572418001400 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 572418001401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418001402 NAD(P) binding site [chemical binding]; other site 572418001403 active site 572418001404 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 572418001405 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572418001406 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 572418001407 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 572418001408 putative ADP-binding pocket [chemical binding]; other site 572418001410 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 572418001411 L-lysine exporter; Region: 2a75; TIGR00948 572418001412 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418001413 catalytic core [active] 572418001414 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 572418001417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572418001418 dimer interface [polypeptide binding]; other site 572418001419 phosphorylation site [posttranslational modification] 572418001420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418001421 ATP binding site [chemical binding]; other site 572418001422 Mg2+ binding site [ion binding]; other site 572418001423 G-X-G motif; other site 572418001424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418001425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418001426 active site 572418001427 phosphorylation site [posttranslational modification] 572418001428 intermolecular recognition site; other site 572418001429 dimerization interface [polypeptide binding]; other site 572418001430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418001431 DNA binding site [nucleotide binding] 572418001432 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 572418001433 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 572418001436 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572418001437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572418001438 DNA-binding site [nucleotide binding]; DNA binding site 572418001439 FCD domain; Region: FCD; pfam07729 572418001441 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 572418001442 exopolyphosphatase; Region: exo_poly_only; TIGR03706 572418001443 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 572418001444 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 572418001445 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 572418001446 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 572418001447 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 572418001448 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 572418001449 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 572418001450 DNA binding domain, excisionase family; Region: excise; TIGR01764 572418001451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572418001452 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 572418001453 putative NAD(P) binding site [chemical binding]; other site 572418001454 active site 572418001455 putative substrate binding site [chemical binding]; other site 572418001456 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418001457 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 572418001458 putative acyl-acceptor binding pocket; other site 572418001459 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418001460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572418001461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001462 S-adenosylmethionine binding site [chemical binding]; other site 572418001463 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 572418001464 active site 572418001465 catalytic site [active] 572418001466 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 572418001467 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 572418001468 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 572418001469 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418001470 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 572418001471 glutamyl-tRNA reductase; Region: hemA; TIGR01035 572418001472 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 572418001473 tRNA; other site 572418001474 putative tRNA binding site [nucleotide binding]; other site 572418001475 putative NADP binding site [chemical binding]; other site 572418001476 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 572418001478 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 572418001479 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 572418001480 domain interfaces; other site 572418001481 active site 572418001482 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 572418001483 active site 572418001484 homodimer interface [polypeptide binding]; other site 572418001485 SAM binding site [chemical binding]; other site 572418001486 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 572418001487 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 572418001488 active site 572418001489 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 572418001490 dimer interface [polypeptide binding]; other site 572418001491 active site 572418001492 Schiff base residues; other site 572418001495 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572418001496 anti sigma factor interaction site; other site 572418001497 regulatory phosphorylation site [posttranslational modification]; other site 572418001498 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 572418001499 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 572418001500 active site 572418001501 catalytic triad [active] 572418001502 oxyanion hole [active] 572418001503 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 572418001505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001506 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572418001507 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 572418001509 Domain of unknown function (DUF385); Region: DUF385; pfam04075 572418001510 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 572418001511 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572418001512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418001513 catalytic residue [active] 572418001515 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418001516 catalytic core [active] 572418001517 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 572418001518 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572418001519 catalytic residues [active] 572418001521 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 572418001522 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 572418001523 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 572418001524 ResB-like family; Region: ResB; pfam05140 572418001525 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 572418001526 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572418001527 AAA domain; Region: AAA_31; pfam13614 572418001528 P-loop; other site 572418001529 Magnesium ion binding site [ion binding]; other site 572418001530 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 572418001531 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 572418001533 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 572418001534 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 572418001535 dimer interface [polypeptide binding]; other site 572418001536 active site 572418001537 CoA binding pocket [chemical binding]; other site 572418001538 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 572418001539 UbiA prenyltransferase family; Region: UbiA; pfam01040 572418001540 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 572418001541 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572418001542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418001543 NAD(P) binding site [chemical binding]; other site 572418001544 active site 572418001545 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 572418001546 Ligand binding site; other site 572418001547 Putative Catalytic site; other site 572418001548 DXD motif; other site 572418001550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 572418001552 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 572418001553 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418001554 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418001555 acyl-activating enzyme (AAE) consensus motif; other site 572418001556 acyl-activating enzyme (AAE) consensus motif; other site 572418001557 AMP binding site [chemical binding]; other site 572418001558 active site 572418001559 CoA binding site [chemical binding]; other site 572418001561 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 572418001562 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 572418001563 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418001564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 572418001565 active site 572418001566 short chain dehydrogenase; Provisional; Region: PRK05866 572418001567 classical (c) SDRs; Region: SDR_c; cd05233 572418001568 NAD(P) binding site [chemical binding]; other site 572418001569 active site 572418001570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418001571 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 572418001572 substrate binding site [chemical binding]; other site 572418001573 oxyanion hole (OAH) forming residues; other site 572418001574 trimer interface [polypeptide binding]; other site 572418001576 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 572418001577 acyl-CoA synthetase; Validated; Region: PRK06188 572418001578 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 572418001579 putative active site [active] 572418001580 putative CoA binding site [chemical binding]; other site 572418001581 putative AMP binding site [chemical binding]; other site 572418001583 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 572418001584 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 572418001585 active site 572418001586 O-succinylbenzoate synthase; Provisional; Region: PRK02901 572418001587 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 572418001588 active site 572418001589 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418001590 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 572418001591 TAP-like protein; Region: Abhydrolase_4; pfam08386 572418001592 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 572418001593 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 572418001594 dimer interface [polypeptide binding]; other site 572418001595 tetramer interface [polypeptide binding]; other site 572418001596 PYR/PP interface [polypeptide binding]; other site 572418001597 TPP binding site [chemical binding]; other site 572418001598 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 572418001599 TPP-binding site; other site 572418001600 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 572418001601 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572418001602 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 572418001603 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 572418001604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001605 S-adenosylmethionine binding site [chemical binding]; other site 572418001606 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418001607 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572418001608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001609 S-adenosylmethionine binding site [chemical binding]; other site 572418001610 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 572418001611 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 572418001612 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572418001613 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572418001614 substrate binding pocket [chemical binding]; other site 572418001615 chain length determination region; other site 572418001616 substrate-Mg2+ binding site; other site 572418001617 catalytic residues [active] 572418001618 aspartate-rich region 1; other site 572418001619 active site lid residues [active] 572418001620 aspartate-rich region 2; other site 572418001622 heat shock protein HtpX; Provisional; Region: PRK03072 572418001624 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 572418001625 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572418001626 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 572418001628 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418001629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572418001630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 572418001631 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 572418001632 O-methyltransferase; Region: Methyltransf_2; pfam00891 572418001633 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418001634 Cytochrome P450; Region: p450; cl12078 572418001636 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 572418001637 ATP cone domain; Region: ATP-cone; pfam03477 572418001638 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 572418001639 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 572418001640 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 572418001641 active site 572418001642 dimer interface [polypeptide binding]; other site 572418001643 effector binding site; other site 572418001644 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 572418001645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418001646 active site 572418001647 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572418001648 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572418001649 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 572418001650 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 572418001651 active site 572418001652 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 572418001653 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 572418001654 putative active site [active] 572418001655 putative metal binding site [ion binding]; other site 572418001657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418001658 dimerization interface [polypeptide binding]; other site 572418001659 putative DNA binding site [nucleotide binding]; other site 572418001660 putative Zn2+ binding site [ion binding]; other site 572418001661 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 572418001662 putative hydrophobic ligand binding site [chemical binding]; other site 572418001663 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 572418001664 TIGR03086 family protein; Region: TIGR03086 572418001665 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 572418001666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418001667 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 572418001668 PE family; Region: PE; pfam00934 572418001671 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 572418001672 Uncharacterized conserved protein [Function unknown]; Region: COG1656 572418001673 Protein of unknown function DUF82; Region: DUF82; pfam01927 572418001674 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418001675 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 572418001676 putative active site [active] 572418001677 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 572418001679 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 572418001680 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 572418001683 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572418001684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572418001685 DNA-binding site [nucleotide binding]; DNA binding site 572418001686 FCD domain; Region: FCD; pfam07729 572418001688 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 572418001689 Permease; Region: Permease; pfam02405 572418001690 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 572418001691 Permease; Region: Permease; pfam02405 572418001692 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418001693 mce related protein; Region: MCE; pfam02470 572418001694 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 572418001695 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 572418001696 mce related protein; Region: MCE; pfam02470 572418001697 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 572418001698 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418001699 mce related protein; Region: MCE; pfam02470 572418001701 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418001702 mce related protein; Region: MCE; pfam02470 572418001703 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 572418001704 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418001705 mce related protein; Region: MCE; pfam02470 572418001707 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418001708 mce related protein; Region: MCE; pfam02470 572418001709 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572418001710 oligomeric interface; other site 572418001711 putative active site [active] 572418001712 homodimer interface [polypeptide binding]; other site 572418001713 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 572418001714 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 572418001715 AAA domain; Region: AAA_14; pfam13173 572418001717 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 572418001718 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 572418001719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572418001720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418001721 ATP binding site [chemical binding]; other site 572418001722 Mg2+ binding site [ion binding]; other site 572418001723 G-X-G motif; other site 572418001724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418001725 dimerization interface [polypeptide binding]; other site 572418001726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418001727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418001728 active site 572418001729 phosphorylation site [posttranslational modification] 572418001730 intermolecular recognition site; other site 572418001731 dimerization interface [polypeptide binding]; other site 572418001732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418001733 DNA binding site [nucleotide binding] 572418001734 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 572418001735 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 572418001737 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 572418001738 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 572418001739 catalytic residues [active] 572418001740 catalytic nucleophile [active] 572418001742 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572418001743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572418001744 Probable transposase; Region: OrfB_IS605; pfam01385 572418001745 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 572418001746 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 572418001747 putative active site [active] 572418001748 SEC-C motif; Region: SEC-C; pfam02810 572418001749 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 572418001750 putative active site [active] 572418001751 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 572418001752 dimer interface [polypeptide binding]; other site 572418001753 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 572418001754 active site 572418001755 galactokinase; Provisional; Region: PRK00555 572418001756 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 572418001760 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418001761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 572418001762 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 572418001763 putative active site [active] 572418001764 Uncharacterized conserved protein [Function unknown]; Region: COG0398 572418001765 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572418001766 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 572418001767 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572418001768 oligomeric interface; other site 572418001769 putative active site [active] 572418001770 homodimer interface [polypeptide binding]; other site 572418001771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 572418001772 FIST N domain; Region: FIST; pfam08495 572418001773 FIST C domain; Region: FIST_C; pfam10442 572418001774 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 572418001775 AAA domain; Region: AAA_30; pfam13604 572418001776 Family description; Region: UvrD_C_2; pfam13538 572418001778 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 572418001779 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 572418001781 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 572418001782 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 572418001783 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 572418001784 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418001785 substrate binding site [chemical binding]; other site 572418001786 oxyanion hole (OAH) forming residues; other site 572418001787 trimer interface [polypeptide binding]; other site 572418001788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 572418001789 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 572418001790 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 572418001791 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 572418001792 active site 572418001793 catalytic site [active] 572418001794 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 572418001795 active site 572418001796 catalytic site [active] 572418001797 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 572418001798 active site 572418001799 catalytic site [active] 572418001800 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 572418001802 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 572418001803 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 572418001804 putative homodimer interface [polypeptide binding]; other site 572418001805 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 572418001806 heterodimer interface [polypeptide binding]; other site 572418001807 homodimer interface [polypeptide binding]; other site 572418001809 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 572418001810 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 572418001811 23S rRNA interface [nucleotide binding]; other site 572418001812 L7/L12 interface [polypeptide binding]; other site 572418001813 putative thiostrepton binding site; other site 572418001814 L25 interface [polypeptide binding]; other site 572418001816 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 572418001817 mRNA/rRNA interface [nucleotide binding]; other site 572418001818 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418001819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001820 S-adenosylmethionine binding site [chemical binding]; other site 572418001821 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418001822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572418001823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001824 S-adenosylmethionine binding site [chemical binding]; other site 572418001825 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418001826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572418001827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001828 S-adenosylmethionine binding site [chemical binding]; other site 572418001829 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418001830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572418001831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418001832 S-adenosylmethionine binding site [chemical binding]; other site 572418001833 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418001834 TAP-like protein; Region: Abhydrolase_4; pfam08386 572418001835 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 572418001836 ABC1 family; Region: ABC1; cl17513 572418001837 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 572418001838 active site 572418001839 catalytic site [active] 572418001840 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 572418001841 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 572418001842 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 572418001844 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 572418001845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572418001847 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 572418001848 23S rRNA interface [nucleotide binding]; other site 572418001849 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 572418001850 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 572418001851 core dimer interface [polypeptide binding]; other site 572418001852 peripheral dimer interface [polypeptide binding]; other site 572418001853 L10 interface [polypeptide binding]; other site 572418001854 L11 interface [polypeptide binding]; other site 572418001855 putative EF-Tu interaction site [polypeptide binding]; other site 572418001856 putative EF-G interaction site [polypeptide binding]; other site 572418001857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418001858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418001859 WHG domain; Region: WHG; pfam13305 572418001860 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 572418001861 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 572418001862 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 572418001863 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 572418001864 Walker A/P-loop; other site 572418001865 ATP binding site [chemical binding]; other site 572418001866 Q-loop/lid; other site 572418001867 ABC transporter signature motif; other site 572418001868 Walker B; other site 572418001869 D-loop; other site 572418001870 H-loop/switch region; other site 572418001873 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 572418001874 putative active site [active] 572418001875 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 572418001876 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 572418001877 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 572418001878 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 572418001879 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 572418001880 Sulfatase; Region: Sulfatase; pfam00884 572418001881 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 572418001883 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 572418001884 putative active site [active] 572418001885 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 572418001886 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 572418001887 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 572418001888 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 572418001889 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 572418001890 RPB10 interaction site [polypeptide binding]; other site 572418001891 RPB1 interaction site [polypeptide binding]; other site 572418001892 RPB11 interaction site [polypeptide binding]; other site 572418001893 RPB3 interaction site [polypeptide binding]; other site 572418001894 RPB12 interaction site [polypeptide binding]; other site 572418001895 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 572418001896 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 572418001897 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 572418001898 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 572418001899 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 572418001900 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 572418001901 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 572418001902 G-loop; other site 572418001903 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 572418001904 DNA binding site [nucleotide binding] 572418001905 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 572418001906 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 572418001908 endonuclease IV; Provisional; Region: PRK01060 572418001909 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 572418001910 AP (apurinic/apyrimidinic) site pocket; other site 572418001911 DNA interaction; other site 572418001912 Metal-binding active site; metal-binding site 572418001915 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 572418001916 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 572418001918 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 572418001919 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418001920 active site 572418001922 enoyl-CoA hydratase; Provisional; Region: PRK12478 572418001923 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418001924 substrate binding site [chemical binding]; other site 572418001925 oxyanion hole (OAH) forming residues; other site 572418001926 trimer interface [polypeptide binding]; other site 572418001928 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 572418001929 PaaX-like protein; Region: PaaX; pfam07848 572418001930 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 572418001931 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 572418001932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418001933 substrate binding site [chemical binding]; other site 572418001934 oxyanion hole (OAH) forming residues; other site 572418001935 trimer interface [polypeptide binding]; other site 572418001937 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418001938 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 572418001939 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 572418001940 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 572418001941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418001942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418001943 WHG domain; Region: WHG; pfam13305 572418001944 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 572418001945 S17 interaction site [polypeptide binding]; other site 572418001946 S8 interaction site; other site 572418001947 16S rRNA interaction site [nucleotide binding]; other site 572418001948 streptomycin interaction site [chemical binding]; other site 572418001949 23S rRNA interaction site [nucleotide binding]; other site 572418001950 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 572418001952 30S ribosomal protein S7; Validated; Region: PRK05302 572418001954 elongation factor G; Reviewed; Region: PRK00007 572418001955 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 572418001956 G1 box; other site 572418001957 putative GEF interaction site [polypeptide binding]; other site 572418001958 GTP/Mg2+ binding site [chemical binding]; other site 572418001959 Switch I region; other site 572418001960 G2 box; other site 572418001961 G3 box; other site 572418001962 Switch II region; other site 572418001963 G4 box; other site 572418001964 G5 box; other site 572418001965 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 572418001966 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 572418001967 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 572418001970 elongation factor Tu; Reviewed; Region: PRK00049 572418001971 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 572418001972 G1 box; other site 572418001973 GEF interaction site [polypeptide binding]; other site 572418001974 GTP/Mg2+ binding site [chemical binding]; other site 572418001975 Switch I region; other site 572418001976 G2 box; other site 572418001977 G3 box; other site 572418001978 Switch II region; other site 572418001979 G4 box; other site 572418001980 G5 box; other site 572418001981 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 572418001982 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 572418001983 Antibiotic Binding Site [chemical binding]; other site 572418001986 Short C-terminal domain; Region: SHOCT; pfam09851 572418001987 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 572418001988 classical (c) SDRs; Region: SDR_c; cd05233 572418001989 NAD(P) binding site [chemical binding]; other site 572418001990 active site 572418001992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 572418001993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418001994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 572418001995 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 572418001996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418001998 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 572418001999 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 572418002000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418002001 FeS/SAM binding site; other site 572418002002 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 572418002003 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 572418002004 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572418002005 phosphate binding site [ion binding]; other site 572418002006 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 572418002007 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 572418002008 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 572418002009 Probable Catalytic site; other site 572418002010 metal-binding site 572418002011 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 572418002012 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 572418002014 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 572418002016 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 572418002018 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 572418002019 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 572418002021 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 572418002022 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 572418002023 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 572418002025 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 572418002027 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 572418002028 putative translocon binding site; other site 572418002029 protein-rRNA interface [nucleotide binding]; other site 572418002031 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 572418002032 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 572418002033 G-X-X-G motif; other site 572418002034 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 572418002035 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 572418002036 23S rRNA interface [nucleotide binding]; other site 572418002037 5S rRNA interface [nucleotide binding]; other site 572418002038 putative antibiotic binding site [chemical binding]; other site 572418002039 L25 interface [polypeptide binding]; other site 572418002040 L27 interface [polypeptide binding]; other site 572418002042 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 572418002043 putative translocon interaction site; other site 572418002044 23S rRNA interface [nucleotide binding]; other site 572418002045 signal recognition particle (SRP54) interaction site; other site 572418002046 L23 interface [polypeptide binding]; other site 572418002047 trigger factor interaction site; other site 572418002048 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 572418002054 Uncharacterized conserved protein [Function unknown]; Region: COG1262 572418002055 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 572418002056 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 572418002058 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 572418002059 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 572418002060 RNA binding site [nucleotide binding]; other site 572418002062 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 572418002063 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 572418002064 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 572418002065 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 572418002067 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 572418002069 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 572418002070 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572418002071 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572418002073 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 572418002074 5S rRNA interface [nucleotide binding]; other site 572418002075 23S rRNA interface [nucleotide binding]; other site 572418002076 L5 interface [polypeptide binding]; other site 572418002077 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 572418002078 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 572418002079 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 572418002082 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 572418002083 23S rRNA binding site [nucleotide binding]; other site 572418002084 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 572418002087 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 572418002088 tandem repeat interface [polypeptide binding]; other site 572418002089 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 572418002090 oligomer interface [polypeptide binding]; other site 572418002091 active site residues [active] 572418002092 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 572418002093 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 572418002094 tandem repeat interface [polypeptide binding]; other site 572418002095 oligomer interface [polypeptide binding]; other site 572418002096 active site residues [active] 572418002097 Leucine carboxyl methyltransferase; Region: LCM; cl01306 572418002098 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418002099 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418002100 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418002101 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418002102 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 572418002103 intersubunit interface [polypeptide binding]; other site 572418002104 active site 572418002105 Zn2+ binding site [ion binding]; other site 572418002106 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 572418002107 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 572418002108 NAD binding site [chemical binding]; other site 572418002109 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 572418002110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572418002111 nucleotide binding site [chemical binding]; other site 572418002112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572418002113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418002114 Coenzyme A binding pocket [chemical binding]; other site 572418002115 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418002116 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418002117 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 572418002118 SecY translocase; Region: SecY; pfam00344 572418002121 adenylate kinase; Reviewed; Region: adk; PRK00279 572418002122 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 572418002123 AMP-binding site [chemical binding]; other site 572418002124 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 572418002126 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 572418002127 active site 572418002128 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 572418002129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418002130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418002131 DNA binding residues [nucleotide binding] 572418002133 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 572418002134 Putative zinc-finger; Region: zf-HC2; pfam13490 572418002135 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572418002136 MarR family; Region: MarR; pfam01047 572418002137 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 572418002138 TIGR03086 family protein; Region: TIGR03086 572418002140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 572418002141 Transposase; Region: DDE_Tnp_ISL3; pfam01610 572418002142 PE family; Region: PE; pfam00934 572418002143 Helix-turn-helix domain; Region: HTH_17; pfam12728 572418002144 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 572418002145 PE family; Region: PE; pfam00934 572418002147 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418002148 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418002149 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572418002150 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 572418002152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418002153 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 572418002154 substrate binding pocket [chemical binding]; other site 572418002155 FAD binding site [chemical binding]; other site 572418002156 catalytic base [active] 572418002159 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 572418002160 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 572418002161 tetrameric interface [polypeptide binding]; other site 572418002162 NAD binding site [chemical binding]; other site 572418002163 catalytic residues [active] 572418002165 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418002166 catalytic core [active] 572418002167 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418002168 PPE family; Region: PPE; pfam00823 572418002169 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418002170 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418002171 Helix-turn-helix domain; Region: HTH_28; pfam13518 572418002172 Winged helix-turn helix; Region: HTH_29; pfam13551 572418002173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418002174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418002175 active site 572418002176 phosphorylation site [posttranslational modification] 572418002177 intermolecular recognition site; other site 572418002178 dimerization interface [polypeptide binding]; other site 572418002179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418002180 DNA binding site [nucleotide binding] 572418002181 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418002182 dimerization interface [polypeptide binding]; other site 572418002183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572418002184 dimer interface [polypeptide binding]; other site 572418002185 phosphorylation site [posttranslational modification] 572418002186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418002187 ATP binding site [chemical binding]; other site 572418002188 Mg2+ binding site [ion binding]; other site 572418002189 G-X-G motif; other site 572418002190 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 572418002191 nucleotide binding site/active site [active] 572418002192 HIT family signature motif; other site 572418002193 catalytic residue [active] 572418002194 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 572418002195 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 572418002196 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 572418002197 NAD binding site [chemical binding]; other site 572418002198 catalytic Zn binding site [ion binding]; other site 572418002199 substrate binding site [chemical binding]; other site 572418002200 structural Zn binding site [ion binding]; other site 572418002202 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 572418002204 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 572418002205 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 572418002206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418002207 Cytochrome P450; Region: p450; cl12078 572418002209 short chain dehydrogenase; Provisional; Region: PRK07775 572418002210 classical (c) SDRs; Region: SDR_c; cd05233 572418002211 NAD(P) binding site [chemical binding]; other site 572418002212 active site 572418002214 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418002215 Cytochrome P450; Region: p450; cl12078 572418002217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418002218 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 572418002219 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 572418002220 NAD binding site [chemical binding]; other site 572418002221 catalytic residues [active] 572418002223 short chain dehydrogenase; Provisional; Region: PRK07774 572418002224 classical (c) SDRs; Region: SDR_c; cd05233 572418002225 NAD(P) binding site [chemical binding]; other site 572418002226 active site 572418002227 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572418002228 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 572418002229 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 572418002230 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 572418002231 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 572418002232 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 572418002233 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 572418002234 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 572418002235 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 572418002236 Predicted esterase [General function prediction only]; Region: COG0627 572418002237 S-formylglutathione hydrolase; Region: PLN02442 572418002240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 572418002241 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 572418002242 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 572418002243 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 572418002244 tetramer interface [polypeptide binding]; other site 572418002245 active site 572418002247 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418002248 Cytochrome P450; Region: p450; cl12078 572418002250 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 572418002251 ATP binding site [chemical binding]; other site 572418002252 active site 572418002253 substrate binding site [chemical binding]; other site 572418002255 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 572418002256 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572418002257 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572418002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418002259 putative substrate translocation pore; other site 572418002260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418002261 Predicted deacetylase [General function prediction only]; Region: COG3233 572418002262 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 572418002263 putative active site [active] 572418002264 putative Zn binding site [ion binding]; other site 572418002266 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 572418002267 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 572418002268 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 572418002269 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 572418002270 putative active site [active] 572418002271 catalytic triad [active] 572418002273 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572418002274 Transglutaminase/protease-like homologues; Region: TGc; smart00460 572418002275 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418002276 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 572418002277 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418002278 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 572418002279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572418002280 DNA-binding site [nucleotide binding]; DNA binding site 572418002281 UTRA domain; Region: UTRA; pfam07702 572418002282 Uncharacterized conserved protein [Function unknown]; Region: COG1359 572418002283 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 572418002284 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 572418002285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418002286 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572418002288 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 572418002289 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 572418002290 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 572418002291 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 572418002292 active site 572418002293 metal binding site [ion binding]; metal-binding site 572418002294 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 572418002295 active site 572418002296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418002297 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572418002298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572418002299 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 572418002300 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 572418002301 dimerization interface [polypeptide binding]; other site 572418002302 ATP binding site [chemical binding]; other site 572418002303 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 572418002304 dimerization interface [polypeptide binding]; other site 572418002305 ATP binding site [chemical binding]; other site 572418002306 CAAX protease self-immunity; Region: Abi; pfam02517 572418002308 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 572418002309 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 572418002310 active site 572418002311 metal binding site [ion binding]; metal-binding site 572418002312 hexamer interface [polypeptide binding]; other site 572418002313 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 572418002314 amidophosphoribosyltransferase; Provisional; Region: PRK07847 572418002315 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 572418002316 active site 572418002317 tetramer interface [polypeptide binding]; other site 572418002318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418002319 active site 572418002321 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 572418002322 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 572418002323 dimerization interface [polypeptide binding]; other site 572418002324 putative ATP binding site [chemical binding]; other site 572418002325 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 572418002326 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 572418002327 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 572418002328 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 572418002329 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 572418002330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418002331 catalytic residue [active] 572418002332 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 572418002333 heme-binding site [chemical binding]; other site 572418002334 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 572418002335 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 572418002336 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 572418002337 active site residue [active] 572418002338 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 572418002339 active site residue [active] 572418002340 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572418002341 catalytic residues [active] 572418002342 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 572418002343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418002344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418002345 DNA binding site [nucleotide binding] 572418002346 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 572418002347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418002348 Coenzyme A binding pocket [chemical binding]; other site 572418002349 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 572418002350 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 572418002351 Walker A/P-loop; other site 572418002352 ATP binding site [chemical binding]; other site 572418002353 Q-loop/lid; other site 572418002354 ABC transporter signature motif; other site 572418002355 Walker B; other site 572418002356 D-loop; other site 572418002357 H-loop/switch region; other site 572418002360 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 572418002361 PhoU domain; Region: PhoU; pfam01895 572418002362 PhoU domain; Region: PhoU; pfam01895 572418002363 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 572418002364 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 572418002366 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 572418002367 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 572418002368 FMN binding site [chemical binding]; other site 572418002369 active site 572418002370 catalytic residues [active] 572418002371 substrate binding site [chemical binding]; other site 572418002373 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 572418002374 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 572418002375 homodimer interface [polypeptide binding]; other site 572418002376 putative substrate binding pocket [chemical binding]; other site 572418002377 diiron center [ion binding]; other site 572418002379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 572418002380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418002381 dimerization interface [polypeptide binding]; other site 572418002382 putative DNA binding site [nucleotide binding]; other site 572418002383 putative Zn2+ binding site [ion binding]; other site 572418002384 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 572418002385 dimer interface [polypeptide binding]; other site 572418002386 catalytic motif [active] 572418002387 nucleoside/Zn binding site; other site 572418002389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572418002390 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418002391 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418002392 TIGR04255 family protein; Region: sporadTIGR04255 572418002393 PE family; Region: PE; pfam00934 572418002394 PE family; Region: PE; pfam00934 572418002395 PknH-like extracellular domain; Region: PknH_C; pfam14032 572418002397 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 572418002398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 572418002399 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 572418002400 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 572418002402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418002403 S-adenosylmethionine binding site [chemical binding]; other site 572418002404 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 572418002405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418002406 putative substrate translocation pore; other site 572418002407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572418002408 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 572418002409 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 572418002410 tetramer interface [polypeptide binding]; other site 572418002411 TPP-binding site [chemical binding]; other site 572418002412 heterodimer interface [polypeptide binding]; other site 572418002413 phosphorylation loop region [posttranslational modification] 572418002414 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572418002415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418002416 active site 572418002417 phosphorylation site [posttranslational modification] 572418002418 intermolecular recognition site; other site 572418002419 dimerization interface [polypeptide binding]; other site 572418002420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572418002421 DNA binding residues [nucleotide binding] 572418002422 dimerization interface [polypeptide binding]; other site 572418002423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572418002424 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 572418002425 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 572418002426 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 572418002427 Multicopper oxidase; Region: Cu-oxidase; pfam00394 572418002428 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 572418002431 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 572418002432 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572418002433 dimer interface [polypeptide binding]; other site 572418002434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418002435 catalytic residue [active] 572418002436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418002437 multidrug resistance protein MdtH; Provisional; Region: PRK11646 572418002438 putative substrate translocation pore; other site 572418002439 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 572418002440 short chain dehydrogenase; Provisional; Region: PRK05876 572418002441 classical (c) SDRs; Region: SDR_c; cd05233 572418002442 NAD(P) binding site [chemical binding]; other site 572418002443 active site 572418002445 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418002447 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 572418002448 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 572418002449 dimer interface [polypeptide binding]; other site 572418002450 PYR/PP interface [polypeptide binding]; other site 572418002451 TPP binding site [chemical binding]; other site 572418002452 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572418002453 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 572418002454 TPP-binding site [chemical binding]; other site 572418002455 dimer interface [polypeptide binding]; other site 572418002458 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 572418002459 putative hydrophobic ligand binding site [chemical binding]; other site 572418002460 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 572418002461 CoA-transferase family III; Region: CoA_transf_3; pfam02515 572418002462 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 572418002463 putative hydrophobic ligand binding site [chemical binding]; other site 572418002464 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 572418002465 putative hydrophobic ligand binding site [chemical binding]; other site 572418002466 aminotransferase; Validated; Region: PRK07777 572418002467 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418002468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418002469 homodimer interface [polypeptide binding]; other site 572418002470 catalytic residue [active] 572418002471 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 572418002472 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572418002473 dimer interface [polypeptide binding]; other site 572418002474 active site 572418002478 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 572418002479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418002480 substrate binding site [chemical binding]; other site 572418002481 oxyanion hole (OAH) forming residues; other site 572418002482 trimer interface [polypeptide binding]; other site 572418002483 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 572418002484 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 572418002485 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 572418002486 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 572418002487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418002488 ATP binding site [chemical binding]; other site 572418002489 putative Mg++ binding site [ion binding]; other site 572418002490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418002491 nucleotide binding region [chemical binding]; other site 572418002492 ATP-binding site [chemical binding]; other site 572418002493 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 572418002494 WYL domain; Region: WYL; pfam13280 572418002495 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 572418002496 trimer interface [polypeptide binding]; other site 572418002497 dimer interface [polypeptide binding]; other site 572418002498 putative active site [active] 572418002499 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 572418002500 MPT binding site; other site 572418002501 trimer interface [polypeptide binding]; other site 572418002502 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 572418002503 MoaE homodimer interface [polypeptide binding]; other site 572418002504 MoaD interaction [polypeptide binding]; other site 572418002505 active site residues [active] 572418002506 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 572418002507 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572418002508 MoaE interaction surface [polypeptide binding]; other site 572418002509 MoeB interaction surface [polypeptide binding]; other site 572418002510 thiocarboxylated glycine; other site 572418002511 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 572418002512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418002513 FeS/SAM binding site; other site 572418002514 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 572418002515 hypothetical protein; Provisional; Region: PRK11770 572418002516 Domain of unknown function (DUF307); Region: DUF307; pfam03733 572418002517 Domain of unknown function (DUF307); Region: DUF307; pfam03733 572418002518 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572418002519 DNA-binding site [nucleotide binding]; DNA binding site 572418002520 RNA-binding motif; other site 572418002521 PE family; Region: PE; pfam00934 572418002523 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418002524 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418002525 active site 572418002526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 572418002527 FIST N domain; Region: FIST; pfam08495 572418002528 FIST C domain; Region: FIST_C; pfam10442 572418002529 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 572418002530 H+ Antiporter protein; Region: 2A0121; TIGR00900 572418002531 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 572418002532 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418002533 PPE family; Region: PPE; pfam00823 572418002534 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418002535 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418002536 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 572418002537 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572418002538 MarR family; Region: MarR; pfam01047 572418002539 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 572418002540 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 572418002541 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572418002542 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 572418002543 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 572418002544 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 572418002545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418002546 catalytic residue [active] 572418002547 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 572418002548 Ferredoxin [Energy production and conversion]; Region: COG1146 572418002549 4Fe-4S binding domain; Region: Fer4; pfam00037 572418002550 ferredoxin-NADP+ reductase; Region: PLN02852 572418002551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418002553 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 572418002554 putative dimer interface [polypeptide binding]; other site 572418002555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418002556 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 572418002557 putative catalytic site [active] 572418002558 putative phosphate binding site [ion binding]; other site 572418002559 putative metal binding site [ion binding]; other site 572418002560 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 572418002561 dimer interface [polypeptide binding]; other site 572418002562 Citrate synthase; Region: Citrate_synt; pfam00285 572418002563 active site 572418002564 citrylCoA binding site [chemical binding]; other site 572418002565 oxalacetate/citrate binding site [chemical binding]; other site 572418002566 coenzyme A binding site [chemical binding]; other site 572418002567 catalytic triad [active] 572418002569 Predicted ATPase [General function prediction only]; Region: COG3903 572418002570 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572418002571 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572418002572 DNA binding residues [nucleotide binding] 572418002573 dimerization interface [polypeptide binding]; other site 572418002576 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418002577 cyclase homology domain; Region: CHD; cd07302 572418002578 nucleotidyl binding site; other site 572418002579 metal binding site [ion binding]; metal-binding site 572418002580 dimer interface [polypeptide binding]; other site 572418002581 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418002582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572418002583 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418002584 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418002585 AAA ATPase domain; Region: AAA_16; pfam13191 572418002586 Predicted ATPase [General function prediction only]; Region: COG3903 572418002588 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418002589 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418002590 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 572418002591 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 572418002592 dimer interface [polypeptide binding]; other site 572418002593 active site 572418002594 citrylCoA binding site [chemical binding]; other site 572418002595 NADH binding [chemical binding]; other site 572418002596 cationic pore residues; other site 572418002597 oxalacetate/citrate binding site [chemical binding]; other site 572418002598 coenzyme A binding site [chemical binding]; other site 572418002599 catalytic triad [active] 572418002601 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 572418002602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418002603 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 572418002604 BON domain; Region: BON; pfam04972 572418002605 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 572418002606 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 572418002607 ligand binding site [chemical binding]; other site 572418002609 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 572418002610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572418002611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418002612 dimerization interface [polypeptide binding]; other site 572418002613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572418002614 dimer interface [polypeptide binding]; other site 572418002615 phosphorylation site [posttranslational modification] 572418002616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418002617 Mg2+ binding site [ion binding]; other site 572418002618 G-X-G motif; other site 572418002619 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418002620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418002621 active site 572418002622 phosphorylation site [posttranslational modification] 572418002623 intermolecular recognition site; other site 572418002624 dimerization interface [polypeptide binding]; other site 572418002625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418002626 DNA binding site [nucleotide binding] 572418002627 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 572418002628 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 572418002629 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 572418002630 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418002631 substrate binding site [chemical binding]; other site 572418002632 oxyanion hole (OAH) forming residues; other site 572418002633 trimer interface [polypeptide binding]; other site 572418002634 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 572418002635 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 572418002637 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572418002638 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418002639 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572418002642 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 572418002643 hydrophobic ligand binding site; other site 572418002644 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 572418002645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418002646 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 572418002647 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418002648 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 572418002649 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 572418002650 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 572418002651 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 572418002652 active site 572418002653 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418002654 PPE family; Region: PPE; pfam00823 572418002656 PE family; Region: PE; pfam00934 572418002657 BCCT family transporter; Region: BCCT; pfam02028 572418002658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 572418002659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418002660 Coenzyme A binding pocket [chemical binding]; other site 572418002661 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418002662 MULE transposase domain; Region: MULE; pfam10551 572418002664 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 572418002665 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 572418002666 catalytic residues [active] 572418002667 catalytic nucleophile [active] 572418002668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572418002669 Probable transposase; Region: OrfB_IS605; pfam01385 572418002670 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 572418002671 putative active site pocket [active] 572418002672 dimerization interface [polypeptide binding]; other site 572418002673 putative catalytic residue [active] 572418002674 Phage-related replication protein [General function prediction only]; Region: COG4195 572418002675 manganese transport protein MntH; Reviewed; Region: PRK00701 572418002676 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 572418002677 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 572418002678 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572418002679 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 572418002680 short chain dehydrogenase; Provisional; Region: PRK07814 572418002681 classical (c) SDRs; Region: SDR_c; cd05233 572418002682 NAD(P) binding site [chemical binding]; other site 572418002683 active site 572418002686 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 572418002688 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 572418002689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418002690 dimer interface [polypeptide binding]; other site 572418002691 conserved gate region; other site 572418002692 putative PBP binding loops; other site 572418002693 ABC-ATPase subunit interface; other site 572418002695 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 572418002696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418002697 dimer interface [polypeptide binding]; other site 572418002698 conserved gate region; other site 572418002699 putative PBP binding loops; other site 572418002700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 572418002701 ABC-ATPase subunit interface; other site 572418002702 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418002703 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418002704 active site 572418002705 ATP binding site [chemical binding]; other site 572418002706 substrate binding site [chemical binding]; other site 572418002707 activation loop (A-loop); other site 572418002708 Uncharacterized conserved protein [Function unknown]; Region: COG3391 572418002709 NHL repeat; Region: NHL; pfam01436 572418002710 NHL repeat; Region: NHL; pfam01436 572418002711 NHL repeat; Region: NHL; pfam01436 572418002712 NHL repeat; Region: NHL; pfam01436 572418002713 NHL repeat; Region: NHL; pfam01436 572418002716 PBP superfamily domain; Region: PBP_like_2; cl17296 572418002721 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 572418002723 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 572418002724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418002725 dimer interface [polypeptide binding]; other site 572418002726 conserved gate region; other site 572418002727 putative PBP binding loops; other site 572418002728 ABC-ATPase subunit interface; other site 572418002730 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 572418002731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418002732 dimer interface [polypeptide binding]; other site 572418002733 conserved gate region; other site 572418002734 putative PBP binding loops; other site 572418002735 ABC-ATPase subunit interface; other site 572418002737 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 572418002738 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 572418002739 putative DNA binding site [nucleotide binding]; other site 572418002740 putative homodimer interface [polypeptide binding]; other site 572418002741 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 572418002742 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 572418002743 nucleotide binding site [chemical binding]; other site 572418002744 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 572418002745 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 572418002746 active site 572418002747 DNA binding site [nucleotide binding] 572418002748 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 572418002749 DNA binding site [nucleotide binding] 572418002750 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 572418002751 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 572418002752 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572418002753 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 572418002754 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418002755 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572418002756 anti sigma factor interaction site; other site 572418002757 regulatory phosphorylation site [posttranslational modification]; other site 572418002758 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418002759 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 572418002760 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 572418002761 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572418002762 short chain dehydrogenase; Provisional; Region: PRK08251 572418002763 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 572418002764 putative NAD(P) binding site [chemical binding]; other site 572418002765 active site 572418002767 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 572418002768 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 572418002769 active site 572418002770 dimer interface [polypeptide binding]; other site 572418002771 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 572418002772 dimer interface [polypeptide binding]; other site 572418002773 active site 572418002776 hypothetical protein; Provisional; Region: PRK07857 572418002777 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 572418002778 Part of AAA domain; Region: AAA_19; pfam13245 572418002779 Family description; Region: UvrD_C_2; pfam13538 572418002781 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572418002782 Peptidase family M23; Region: Peptidase_M23; pfam01551 572418002783 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 572418002784 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 572418002785 CoA-ligase; Region: Ligase_CoA; pfam00549 572418002786 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 572418002787 CoA binding domain; Region: CoA_binding; smart00881 572418002788 CoA-ligase; Region: Ligase_CoA; pfam00549 572418002790 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 572418002791 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418002793 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 572418002794 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 572418002795 active site 572418002796 substrate binding site [chemical binding]; other site 572418002797 cosubstrate binding site; other site 572418002798 catalytic site [active] 572418002799 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 572418002800 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 572418002801 purine monophosphate binding site [chemical binding]; other site 572418002802 dimer interface [polypeptide binding]; other site 572418002803 putative catalytic residues [active] 572418002804 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 572418002805 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 572418002806 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 572418002807 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 572418002809 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 572418002810 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 572418002811 metal ion-dependent adhesion site (MIDAS); other site 572418002812 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 572418002813 homotetrameric interface [polypeptide binding]; other site 572418002814 putative active site [active] 572418002815 metal binding site [ion binding]; metal-binding site 572418002816 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 572418002817 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 572418002818 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 572418002819 putative homodimer interface [polypeptide binding]; other site 572418002820 putative homotetramer interface [polypeptide binding]; other site 572418002821 allosteric switch controlling residues; other site 572418002822 putative metal binding site [ion binding]; other site 572418002823 putative homodimer-homodimer interface [polypeptide binding]; other site 572418002824 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 572418002825 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 572418002826 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418002827 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572418002829 enoyl-CoA hydratase; Provisional; Region: PRK07827 572418002830 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418002831 substrate binding site [chemical binding]; other site 572418002832 oxyanion hole (OAH) forming residues; other site 572418002833 trimer interface [polypeptide binding]; other site 572418002834 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418002835 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 572418002836 active site 572418002837 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 572418002838 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572418002839 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572418002840 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572418002841 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572418002842 carboxyltransferase (CT) interaction site; other site 572418002843 biotinylation site [posttranslational modification]; other site 572418002846 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 572418002847 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572418002848 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418002849 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418002850 active site 572418002852 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 572418002853 PE family; Region: PE; pfam00934 572418002854 PE family; Region: PE; pfam00934 572418002855 Uncharacterized conserved protein [Function unknown]; Region: COG3391 572418002856 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 572418002857 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 572418002858 PE family; Region: PE; pfam00934 572418002859 Uncharacterized conserved protein [Function unknown]; Region: COG3391 572418002860 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 572418002861 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 572418002862 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 572418002863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418002864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418002865 active site 572418002866 phosphorylation site [posttranslational modification] 572418002867 intermolecular recognition site; other site 572418002868 dimerization interface [polypeptide binding]; other site 572418002869 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418002870 DNA binding site [nucleotide binding] 572418002872 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 572418002873 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418002874 dimerization interface [polypeptide binding]; other site 572418002875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572418002876 dimer interface [polypeptide binding]; other site 572418002877 phosphorylation site [posttranslational modification] 572418002878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418002879 ATP binding site [chemical binding]; other site 572418002880 Mg2+ binding site [ion binding]; other site 572418002881 G-X-G motif; other site 572418002882 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 572418002883 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572418002884 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 572418002885 MPT binding site; other site 572418002886 trimer interface [polypeptide binding]; other site 572418002887 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 572418002888 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 572418002889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572418002890 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572418002891 Walker A/P-loop; other site 572418002892 ATP binding site [chemical binding]; other site 572418002893 Q-loop/lid; other site 572418002894 ABC transporter signature motif; other site 572418002895 Walker B; other site 572418002896 D-loop; other site 572418002897 H-loop/switch region; other site 572418002900 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 572418002901 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572418002902 FtsX-like permease family; Region: FtsX; pfam02687 572418002903 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572418002904 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 572418002905 FtsX-like permease family; Region: FtsX; pfam02687 572418002907 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 572418002908 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572418002909 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572418002910 substrate binding pocket [chemical binding]; other site 572418002911 chain length determination region; other site 572418002912 substrate-Mg2+ binding site; other site 572418002913 catalytic residues [active] 572418002914 aspartate-rich region 1; other site 572418002915 active site lid residues [active] 572418002916 aspartate-rich region 2; other site 572418002917 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 572418002918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 572418002919 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 572418002920 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 572418002921 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 572418002922 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 572418002923 active site 572418002924 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 572418002925 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 572418002926 dimer interface [polypeptide binding]; other site 572418002927 putative functional site; other site 572418002928 putative MPT binding site; other site 572418002929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572418002930 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 572418002931 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418002932 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418002933 ligand binding site [chemical binding]; other site 572418002934 flexible hinge region; other site 572418002935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572418002936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418002937 Coenzyme A binding pocket [chemical binding]; other site 572418002939 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 572418002940 arginine deiminase; Provisional; Region: PRK01388 572418002941 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 572418002942 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 572418002944 Predicted methyltransferases [General function prediction only]; Region: COG0313 572418002945 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 572418002946 putative SAM binding site [chemical binding]; other site 572418002947 putative homodimer interface [polypeptide binding]; other site 572418002949 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 572418002950 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 572418002951 active site 572418002952 HIGH motif; other site 572418002953 KMSKS motif; other site 572418002954 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 572418002955 tRNA binding surface [nucleotide binding]; other site 572418002956 anticodon binding site; other site 572418002958 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 572418002959 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 572418002960 active site 572418002963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 572418002964 Domain of unknown function (DUF348); Region: DUF348; pfam03990 572418002965 Domain of unknown function (DUF348); Region: DUF348; pfam03990 572418002966 G5 domain; Region: G5; pfam07501 572418002967 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 572418002969 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 572418002970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418002971 S-adenosylmethionine binding site [chemical binding]; other site 572418002973 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 572418002974 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 572418002975 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 572418002977 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 572418002978 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418002979 acyl-activating enzyme (AAE) consensus motif; other site 572418002980 AMP binding site [chemical binding]; other site 572418002981 active site 572418002982 CoA binding site [chemical binding]; other site 572418002984 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 572418002985 putative active site [active] 572418002986 catalytic residue [active] 572418002987 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 572418002988 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 572418002989 5S rRNA interface [nucleotide binding]; other site 572418002990 CTC domain interface [polypeptide binding]; other site 572418002991 L16 interface [polypeptide binding]; other site 572418002992 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 572418002994 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 572418002995 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 572418002996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418002997 active site 572418003000 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 572418003001 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 572418003002 Substrate binding site; other site 572418003003 Mg++ binding site; other site 572418003004 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 572418003005 active site 572418003006 substrate binding site [chemical binding]; other site 572418003007 CoA binding site [chemical binding]; other site 572418003008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418003009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418003010 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 572418003011 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 572418003012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418003013 ATP binding site [chemical binding]; other site 572418003014 putative Mg++ binding site [ion binding]; other site 572418003015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418003016 nucleotide binding region [chemical binding]; other site 572418003017 ATP-binding site [chemical binding]; other site 572418003018 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 572418003020 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 572418003021 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 572418003022 homodimer interface [polypeptide binding]; other site 572418003023 metal binding site [ion binding]; metal-binding site 572418003024 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 572418003025 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 572418003026 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572418003027 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572418003029 enolase; Provisional; Region: eno; PRK00077 572418003030 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 572418003031 dimer interface [polypeptide binding]; other site 572418003032 metal binding site [ion binding]; metal-binding site 572418003033 substrate binding pocket [chemical binding]; other site 572418003034 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 572418003035 Septum formation initiator; Region: DivIC; pfam04977 572418003036 Uncharacterized conserved protein [Function unknown]; Region: COG1507 572418003037 exopolyphosphatase; Region: exo_poly_only; TIGR03706 572418003038 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 572418003039 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 572418003040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418003041 active site 572418003042 phosphorylation site [posttranslational modification] 572418003043 intermolecular recognition site; other site 572418003044 dimerization interface [polypeptide binding]; other site 572418003045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418003046 DNA binding site [nucleotide binding] 572418003047 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 572418003048 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 572418003049 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 572418003050 Ligand Binding Site [chemical binding]; other site 572418003051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572418003052 dimer interface [polypeptide binding]; other site 572418003053 phosphorylation site [posttranslational modification] 572418003054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418003055 ATP binding site [chemical binding]; other site 572418003056 Mg2+ binding site [ion binding]; other site 572418003057 G-X-G motif; other site 572418003059 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 572418003060 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 572418003061 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418003062 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572418003064 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 572418003065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572418003066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572418003067 dimer interface [polypeptide binding]; other site 572418003068 phosphorylation site [posttranslational modification] 572418003069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418003070 ATP binding site [chemical binding]; other site 572418003071 Mg2+ binding site [ion binding]; other site 572418003072 G-X-G motif; other site 572418003073 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418003074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418003075 active site 572418003076 phosphorylation site [posttranslational modification] 572418003077 intermolecular recognition site; other site 572418003078 dimerization interface [polypeptide binding]; other site 572418003079 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418003080 DNA binding site [nucleotide binding] 572418003081 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 572418003082 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 572418003083 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 572418003084 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 572418003085 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572418003086 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418003087 PPE family; Region: PPE; pfam00823 572418003088 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418003089 PE family; Region: PE; pfam00934 572418003090 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418003091 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572418003092 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 572418003093 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 572418003094 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 572418003095 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572418003096 Predicted transcriptional regulator [Transcription]; Region: COG5340 572418003097 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 572418003098 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 572418003099 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418003100 MULE transposase domain; Region: MULE; pfam10551 572418003101 Transcriptional regulators [Transcription]; Region: MarR; COG1846 572418003102 MarR family; Region: MarR_2; pfam12802 572418003103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418003104 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 572418003105 NAD(P) binding site [chemical binding]; other site 572418003106 active site 572418003107 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 572418003108 Helix-turn-helix domain; Region: HTH_17; pfam12728 572418003109 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 572418003110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572418003111 Domain of unknown function (DUF427); Region: DUF427; cl00998 572418003112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 572418003113 Uncharacterized conserved protein [Function unknown]; Region: COG3391 572418003114 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 572418003115 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 572418003116 dimer interface [polypeptide binding]; other site 572418003117 acyl-activating enzyme (AAE) consensus motif; other site 572418003118 putative active site [active] 572418003119 AMP binding site [chemical binding]; other site 572418003120 putative CoA binding site [chemical binding]; other site 572418003122 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 572418003123 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 572418003124 hydrophobic ligand binding site; other site 572418003125 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 572418003126 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 572418003127 putative active site [active] 572418003128 putative dimer interface [polypeptide binding]; other site 572418003129 Patatin-like phospholipase; Region: Patatin; pfam01734 572418003130 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572418003131 nucleophile elbow; other site 572418003132 hypothetical protein; Provisional; Region: PRK10279 572418003133 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 572418003134 active site 572418003135 nucleophile elbow; other site 572418003137 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 572418003138 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 572418003139 active site residue [active] 572418003140 PE family; Region: PE; pfam00934 572418003142 PE family; Region: PE; pfam00934 572418003143 Predicted membrane protein [Function unknown]; Region: COG4425 572418003144 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 572418003145 enoyl-CoA hydratase; Provisional; Region: PRK05862 572418003146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418003147 substrate binding site [chemical binding]; other site 572418003148 oxyanion hole (OAH) forming residues; other site 572418003149 trimer interface [polypeptide binding]; other site 572418003151 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 572418003152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418003153 substrate binding site [chemical binding]; other site 572418003154 oxyanion hole (OAH) forming residues; other site 572418003155 trimer interface [polypeptide binding]; other site 572418003156 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 572418003157 Predicted membrane protein [Function unknown]; Region: COG4760 572418003158 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 572418003159 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 572418003160 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 572418003161 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572418003162 dimer interface [polypeptide binding]; other site 572418003163 active site 572418003166 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 572418003167 active site 572418003168 catalytic triad [active] 572418003169 oxyanion hole [active] 572418003170 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 572418003171 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 572418003172 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 572418003173 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572418003174 dimer interface [polypeptide binding]; other site 572418003175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418003176 catalytic residue [active] 572418003177 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 572418003179 RDD family; Region: RDD; pfam06271 572418003180 cystathionine gamma-synthase; Provisional; Region: PRK07811 572418003181 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572418003182 homodimer interface [polypeptide binding]; other site 572418003183 substrate-cofactor binding pocket; other site 572418003184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418003185 catalytic residue [active] 572418003187 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 572418003188 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 572418003189 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 572418003192 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 572418003193 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 572418003194 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 572418003195 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 572418003196 catalytic residues [active] 572418003197 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 572418003198 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 572418003199 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 572418003200 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 572418003201 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 572418003202 catalytic residue [active] 572418003203 putative FPP diphosphate binding site; other site 572418003204 putative FPP binding hydrophobic cleft; other site 572418003205 dimer interface [polypeptide binding]; other site 572418003206 putative IPP diphosphate binding site; other site 572418003208 PE family; Region: PE; pfam00934 572418003210 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 572418003211 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 572418003212 putative IPP diphosphate binding site; other site 572418003213 PE family; Region: PE; pfam00934 572418003214 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 572418003215 PE family; Region: PE; pfam00934 572418003216 pantothenate kinase; Provisional; Region: PRK05439 572418003217 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 572418003218 ATP-binding site [chemical binding]; other site 572418003219 CoA-binding site [chemical binding]; other site 572418003220 Mg2+-binding site [ion binding]; other site 572418003222 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 572418003223 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 572418003224 dimer interface [polypeptide binding]; other site 572418003225 active site 572418003226 glycine-pyridoxal phosphate binding site [chemical binding]; other site 572418003227 folate binding site [chemical binding]; other site 572418003228 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 572418003229 dinuclear metal binding motif [ion binding]; other site 572418003230 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 572418003231 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 572418003232 putative active site [active] 572418003233 PhoH-like protein; Region: PhoH; pfam02562 572418003235 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 572418003236 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 572418003237 NodB motif; other site 572418003238 active site 572418003239 catalytic site [active] 572418003240 metal binding site [ion binding]; metal-binding site 572418003241 fumarate hydratase; Reviewed; Region: fumC; PRK00485 572418003242 Class II fumarases; Region: Fumarase_classII; cd01362 572418003243 active site 572418003244 tetramer interface [polypeptide binding]; other site 572418003246 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 572418003247 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 572418003248 putative active site [active] 572418003249 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 572418003251 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 572418003252 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 572418003253 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418003254 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418003255 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 572418003256 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 572418003257 putative NAD(P) binding site [chemical binding]; other site 572418003258 active site 572418003259 putative substrate binding site [chemical binding]; other site 572418003260 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 572418003261 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 572418003262 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 572418003263 generic binding surface II; other site 572418003264 generic binding surface I; other site 572418003265 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 572418003266 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 572418003267 Yip1 domain; Region: Yip1; pfam04893 572418003268 GTP-binding protein YchF; Reviewed; Region: PRK09601 572418003269 YchF GTPase; Region: YchF; cd01900 572418003270 G1 box; other site 572418003271 GTP/Mg2+ binding site [chemical binding]; other site 572418003272 Switch I region; other site 572418003273 G2 box; other site 572418003274 Switch II region; other site 572418003275 G3 box; other site 572418003276 G4 box; other site 572418003277 G5 box; other site 572418003278 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 572418003280 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 572418003281 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 572418003282 putative active site [active] 572418003283 Uncharacterized conserved protein [Function unknown]; Region: COG1359 572418003284 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418003285 cyclase homology domain; Region: CHD; cd07302 572418003286 nucleotidyl binding site; other site 572418003287 metal binding site [ion binding]; metal-binding site 572418003288 dimer interface [polypeptide binding]; other site 572418003289 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 572418003290 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 572418003291 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 572418003292 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572418003293 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 572418003294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572418003296 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418003297 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418003298 pyruvate phosphate dikinase; Provisional; Region: PRK05878 572418003299 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 572418003300 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 572418003301 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418003302 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418003303 active site 572418003304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572418003305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418003306 non-specific DNA binding site [nucleotide binding]; other site 572418003307 salt bridge; other site 572418003308 sequence-specific DNA binding site [nucleotide binding]; other site 572418003309 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 572418003310 Domain of unknown function (DUF955); Region: DUF955; pfam06114 572418003311 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 572418003312 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 572418003313 citrate synthase; Provisional; Region: PRK14033 572418003314 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 572418003315 oxalacetate binding site [chemical binding]; other site 572418003316 citrylCoA binding site [chemical binding]; other site 572418003317 coenzyme A binding site [chemical binding]; other site 572418003318 catalytic triad [active] 572418003320 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 572418003321 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 572418003322 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 572418003323 THF binding site; other site 572418003324 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 572418003325 substrate binding site [chemical binding]; other site 572418003326 THF binding site; other site 572418003327 zinc-binding site [ion binding]; other site 572418003329 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 572418003330 active site 572418003331 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 572418003332 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418003333 substrate binding site [chemical binding]; other site 572418003334 oxyanion hole (OAH) forming residues; other site 572418003336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 572418003337 CAAX protease self-immunity; Region: Abi; pfam02517 572418003338 enoyl-CoA hydratase; Provisional; Region: PRK06688 572418003339 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 572418003340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418003341 trimer interface [polypeptide binding]; other site 572418003342 enoyl-CoA hydratase; Provisional; Region: PRK06688 572418003343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418003344 substrate binding site [chemical binding]; other site 572418003345 oxyanion hole (OAH) forming residues; other site 572418003346 trimer interface [polypeptide binding]; other site 572418003347 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 572418003348 CoA-transferase family III; Region: CoA_transf_3; pfam02515 572418003349 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 572418003350 NAD binding site [chemical binding]; other site 572418003351 homodimer interface [polypeptide binding]; other site 572418003352 homotetramer interface [polypeptide binding]; other site 572418003353 active site 572418003355 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418003356 MMPL family; Region: MMPL; pfam03176 572418003357 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418003358 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418003359 active site 572418003360 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 572418003361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 572418003362 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 572418003363 NAD-dependent deacetylase; Provisional; Region: PRK00481 572418003364 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 572418003365 NAD+ binding site [chemical binding]; other site 572418003366 substrate binding site [chemical binding]; other site 572418003367 Zn binding site [ion binding]; other site 572418003368 Predicted transcriptional regulators [Transcription]; Region: COG1725 572418003369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572418003370 DNA-binding site [nucleotide binding]; DNA binding site 572418003371 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418003372 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 572418003373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 572418003374 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 572418003375 uncharacterized HhH-GPD family protein; Region: TIGR03252 572418003376 minor groove reading motif; other site 572418003377 helix-hairpin-helix signature motif; other site 572418003378 mannosyltransferase; Provisional; Region: pimE; PRK13375 572418003379 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 572418003380 aromatic arch; other site 572418003381 DCoH dimer interaction site [polypeptide binding]; other site 572418003382 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 572418003383 DCoH tetramer interaction site [polypeptide binding]; other site 572418003384 substrate binding site [chemical binding]; other site 572418003385 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 572418003386 active site 572418003387 8-oxo-dGMP binding site [chemical binding]; other site 572418003388 nudix motif; other site 572418003389 metal binding site [ion binding]; metal-binding site 572418003391 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 572418003392 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 572418003393 [4Fe-4S] binding site [ion binding]; other site 572418003394 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572418003395 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572418003396 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572418003397 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 572418003398 molybdopterin cofactor binding site; other site 572418003401 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 572418003402 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 572418003403 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 572418003404 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 572418003405 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 572418003406 G1 box; other site 572418003407 putative GEF interaction site [polypeptide binding]; other site 572418003408 GTP/Mg2+ binding site [chemical binding]; other site 572418003409 Switch I region; other site 572418003410 G2 box; other site 572418003411 G3 box; other site 572418003412 Switch II region; other site 572418003413 G4 box; other site 572418003414 G5 box; other site 572418003415 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 572418003416 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 572418003417 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572418003418 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 572418003419 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 572418003421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418003422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418003423 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418003424 PPE family; Region: PPE; pfam00823 572418003425 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418003426 PE family; Region: PE; pfam00934 572418003427 putative transposase OrfB; Reviewed; Region: PHA02517 572418003428 HTH-like domain; Region: HTH_21; pfam13276 572418003429 Integrase core domain; Region: rve; pfam00665 572418003430 Integrase core domain; Region: rve_3; pfam13683 572418003431 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 572418003432 PE family; Region: PE; pfam00934 572418003433 FO synthase; Reviewed; Region: fbiC; PRK09234 572418003434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418003435 FeS/SAM binding site; other site 572418003436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418003437 FeS/SAM binding site; other site 572418003438 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 572418003439 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 572418003440 active site 572418003441 FMN binding site [chemical binding]; other site 572418003442 2,4-decadienoyl-CoA binding site; other site 572418003443 catalytic residue [active] 572418003444 4Fe-4S cluster binding site [ion binding]; other site 572418003445 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 572418003446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418003447 Predicted transcriptional regulators [Transcription]; Region: COG1695 572418003448 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572418003449 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 572418003450 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 572418003451 4Fe-4S binding domain; Region: Fer4; pfam00037 572418003453 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 572418003454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418003455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418003456 homodimer interface [polypeptide binding]; other site 572418003457 catalytic residue [active] 572418003459 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 572418003460 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 572418003461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572418003462 ATP binding site [chemical binding]; other site 572418003463 putative Mg++ binding site [ion binding]; other site 572418003464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 572418003465 ATP-binding site [chemical binding]; other site 572418003467 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 572418003468 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418003469 active site 572418003471 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572418003472 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418003473 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418003474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418003475 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 572418003476 Enoylreductase; Region: PKS_ER; smart00829 572418003477 NAD(P) binding site [chemical binding]; other site 572418003478 KR domain; Region: KR; pfam08659 572418003479 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 572418003480 putative NADP binding site [chemical binding]; other site 572418003481 active site 572418003482 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418003483 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 572418003484 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418003485 PE-PPE domain; Region: PE-PPE; pfam08237 572418003486 acyl-CoA synthetase; Validated; Region: PRK05850 572418003487 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418003488 acyl-activating enzyme (AAE) consensus motif; other site 572418003489 active site 572418003490 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 572418003491 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572418003492 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 572418003493 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 572418003494 Glutamate binding site [chemical binding]; other site 572418003495 NAD binding site [chemical binding]; other site 572418003496 catalytic residues [active] 572418003497 Proline dehydrogenase; Region: Pro_dh; pfam01619 572418003498 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 572418003499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418003500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418003501 DNA binding residues [nucleotide binding] 572418003502 haloalkane dehalogenase; Provisional; Region: PRK03204 572418003503 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 572418003504 catalytic site [active] 572418003505 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418003506 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 572418003508 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572418003509 PGAP1-like protein; Region: PGAP1; pfam07819 572418003511 acyl-CoA synthetase; Validated; Region: PRK07787 572418003512 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418003513 acyl-activating enzyme (AAE) consensus motif; other site 572418003514 AMP binding site [chemical binding]; other site 572418003515 active site 572418003516 CoA binding site [chemical binding]; other site 572418003518 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 572418003519 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572418003520 PE family; Region: PE; pfam00934 572418003521 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418003522 PPE family; Region: PPE; pfam00823 572418003523 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418003524 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572418003525 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 572418003526 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418003527 MULE transposase domain; Region: MULE; pfam10551 572418003528 metabolite-proton symporter; Region: 2A0106; TIGR00883 572418003529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418003530 putative substrate translocation pore; other site 572418003532 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 572418003533 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 572418003534 putative trimer interface [polypeptide binding]; other site 572418003535 putative CoA binding site [chemical binding]; other site 572418003536 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 572418003537 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 572418003538 metal binding site [ion binding]; metal-binding site 572418003539 putative dimer interface [polypeptide binding]; other site 572418003541 TIGR00730 family protein; Region: TIGR00730 572418003542 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 572418003543 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 572418003544 acyl-activating enzyme (AAE) consensus motif; other site 572418003545 putative AMP binding site [chemical binding]; other site 572418003546 putative active site [active] 572418003547 putative CoA binding site [chemical binding]; other site 572418003550 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 572418003551 dihydropteroate synthase; Region: DHPS; TIGR01496 572418003552 substrate binding pocket [chemical binding]; other site 572418003553 dimer interface [polypeptide binding]; other site 572418003554 inhibitor binding site; inhibition site 572418003557 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 572418003558 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572418003559 DivIVA domain; Region: DivI1A_domain; TIGR03544 572418003560 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 572418003561 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 572418003562 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 572418003563 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572418003564 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 572418003565 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 572418003566 ligand binding site; other site 572418003567 oligomer interface; other site 572418003568 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 572418003569 dimer interface [polypeptide binding]; other site 572418003570 N-terminal domain interface [polypeptide binding]; other site 572418003571 sulfate 1 binding site; other site 572418003572 PE family; Region: PE; pfam00934 572418003573 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 572418003574 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572418003575 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 572418003576 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 572418003577 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 572418003578 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572418003579 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572418003580 Walker A/P-loop; other site 572418003581 ATP binding site [chemical binding]; other site 572418003582 Q-loop/lid; other site 572418003583 ABC transporter signature motif; other site 572418003584 Walker B; other site 572418003585 D-loop; other site 572418003586 H-loop/switch region; other site 572418003587 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 572418003590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418003591 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 572418003592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418003593 S-adenosylmethionine binding site [chemical binding]; other site 572418003594 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 572418003595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418003596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418003597 DNA binding residues [nucleotide binding] 572418003598 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 572418003599 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572418003600 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 572418003601 protein binding site [polypeptide binding]; other site 572418003603 sec-independent translocase; Provisional; Region: PRK03100 572418003604 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 572418003605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418003606 active site 572418003607 motif I; other site 572418003608 motif II; other site 572418003609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418003610 Predicted membrane protein [Function unknown]; Region: COG3428 572418003611 Bacterial PH domain; Region: DUF304; pfam03703 572418003612 Uncharacterized conserved protein [Function unknown]; Region: COG3402 572418003614 Domain of unknown function DUF59; Region: DUF59; cl00941 572418003615 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 572418003616 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 572418003618 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 572418003619 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 572418003620 N-acetyl-D-glucosamine binding site [chemical binding]; other site 572418003621 catalytic residue [active] 572418003622 Predicted membrane protein [Function unknown]; Region: COG4420 572418003623 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 572418003624 MgtE intracellular N domain; Region: MgtE_N; smart00924 572418003625 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 572418003626 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 572418003627 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 572418003628 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 572418003630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418003631 dimer interface [polypeptide binding]; other site 572418003632 conserved gate region; other site 572418003633 putative PBP binding loops; other site 572418003634 ABC-ATPase subunit interface; other site 572418003636 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 572418003637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418003638 dimer interface [polypeptide binding]; other site 572418003639 conserved gate region; other site 572418003640 ABC-ATPase subunit interface; other site 572418003641 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 572418003642 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 572418003643 Walker A/P-loop; other site 572418003644 ATP binding site [chemical binding]; other site 572418003645 Q-loop/lid; other site 572418003646 ABC transporter signature motif; other site 572418003647 Walker B; other site 572418003648 D-loop; other site 572418003649 H-loop/switch region; other site 572418003652 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 572418003653 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 572418003654 oligomer interface [polypeptide binding]; other site 572418003655 metal binding site [ion binding]; metal-binding site 572418003656 metal binding site [ion binding]; metal-binding site 572418003657 putative Cl binding site [ion binding]; other site 572418003658 basic sphincter; other site 572418003659 hydrophobic gate; other site 572418003660 periplasmic entrance; other site 572418003661 malate dehydrogenase; Provisional; Region: PRK05442 572418003662 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 572418003663 NAD(P) binding site [chemical binding]; other site 572418003664 dimer interface [polypeptide binding]; other site 572418003665 malate binding site [chemical binding]; other site 572418003667 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418003668 PE family; Region: PE; pfam00934 572418003669 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 572418003671 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 572418003672 classical (c) SDRs; Region: SDR_c; cd05233 572418003673 NAD(P) binding site [chemical binding]; other site 572418003674 active site 572418003676 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 572418003677 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 572418003678 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 572418003679 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572418003680 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 572418003681 TPP-binding site [chemical binding]; other site 572418003682 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 572418003683 dimer interface [polypeptide binding]; other site 572418003684 PYR/PP interface [polypeptide binding]; other site 572418003685 TPP binding site [chemical binding]; other site 572418003686 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572418003687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418003688 putative substrate translocation pore; other site 572418003689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418003690 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 572418003691 RNase_H superfamily; Region: RNase_H_2; pfam13482 572418003692 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 572418003693 Part of AAA domain; Region: AAA_19; pfam13245 572418003694 AAA domain; Region: AAA_12; pfam13087 572418003696 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 572418003697 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 572418003698 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572418003699 ATP binding site [chemical binding]; other site 572418003700 Mg++ binding site [ion binding]; other site 572418003701 motif III; other site 572418003702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418003703 nucleotide binding region [chemical binding]; other site 572418003704 ATP-binding site [chemical binding]; other site 572418003705 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 572418003706 putative RNA binding site [nucleotide binding]; other site 572418003709 Acyltransferase family; Region: Acyl_transf_3; pfam01757 572418003710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418003711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418003712 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418003714 FAD binding domain; Region: FAD_binding_4; pfam01565 572418003715 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 572418003716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418003717 H+ Antiporter protein; Region: 2A0121; TIGR00900 572418003718 putative substrate translocation pore; other site 572418003720 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 572418003721 Fe-S cluster binding site [ion binding]; other site 572418003722 DNA binding site [nucleotide binding] 572418003723 active site 572418003724 hypothetical protein; Validated; Region: PRK05868 572418003725 hypothetical protein; Provisional; Region: PRK07236 572418003726 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 572418003727 Domain of unknown function (DUF385); Region: DUF385; pfam04075 572418003728 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 572418003729 HIT family signature motif; other site 572418003730 catalytic residue [active] 572418003732 amidase; Provisional; Region: PRK12470 572418003733 Amidase; Region: Amidase; pfam01425 572418003736 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418003737 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418003738 active site 572418003739 ATP binding site [chemical binding]; other site 572418003740 substrate binding site [chemical binding]; other site 572418003741 activation loop (A-loop); other site 572418003742 PknH-like extracellular domain; Region: PknH_C; pfam14032 572418003744 TbD2 572418003745 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418003746 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418003747 phosphopeptide binding site; other site 572418003748 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418003749 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418003750 phosphopeptide binding site; other site 572418003751 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 572418003752 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572418003753 Walker A/P-loop; other site 572418003754 ATP binding site [chemical binding]; other site 572418003755 Q-loop/lid; other site 572418003756 ABC transporter signature motif; other site 572418003757 Walker B; other site 572418003758 D-loop; other site 572418003759 H-loop/switch region; other site 572418003760 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 572418003761 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 572418003762 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418003763 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418003764 active site 572418003765 ATP binding site [chemical binding]; other site 572418003766 substrate binding site [chemical binding]; other site 572418003767 activation loop (A-loop); other site 572418003769 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 572418003770 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 572418003771 DNA binding site [nucleotide binding] 572418003772 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418003773 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418003774 phosphopeptide binding site; other site 572418003775 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 572418003776 putative active site [active] 572418003777 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 572418003778 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 572418003779 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418003780 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572418003781 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 572418003782 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572418003783 Walker A/P-loop; other site 572418003784 ATP binding site [chemical binding]; other site 572418003785 Q-loop/lid; other site 572418003786 ABC transporter signature motif; other site 572418003787 Walker B; other site 572418003788 D-loop; other site 572418003789 H-loop/switch region; other site 572418003792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572418003793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 572418003794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418003795 Walker A/P-loop; other site 572418003796 ATP binding site [chemical binding]; other site 572418003797 Q-loop/lid; other site 572418003798 ABC transporter signature motif; other site 572418003799 Walker B; other site 572418003800 D-loop; other site 572418003801 H-loop/switch region; other site 572418003806 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 572418003807 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 572418003808 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418003809 catalytic core [active] 572418003810 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 572418003811 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 572418003812 active site 572418003813 metal binding site [ion binding]; metal-binding site 572418003814 DNA binding site [nucleotide binding] 572418003815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418003816 Walker A/P-loop; other site 572418003817 ATP binding site [chemical binding]; other site 572418003819 choline dehydrogenase; Validated; Region: PRK02106 572418003820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418003821 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 572418003824 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572418003825 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 572418003826 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 572418003827 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572418003828 Walker A/P-loop; other site 572418003829 ATP binding site [chemical binding]; other site 572418003830 Q-loop/lid; other site 572418003831 ABC transporter signature motif; other site 572418003832 Walker B; other site 572418003833 D-loop; other site 572418003834 H-loop/switch region; other site 572418003835 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572418003836 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572418003837 Walker A/P-loop; other site 572418003838 ATP binding site [chemical binding]; other site 572418003839 Q-loop/lid; other site 572418003840 ABC transporter signature motif; other site 572418003841 Walker B; other site 572418003842 D-loop; other site 572418003843 H-loop/switch region; other site 572418003844 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 572418003849 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 572418003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418003851 dimer interface [polypeptide binding]; other site 572418003852 conserved gate region; other site 572418003853 putative PBP binding loops; other site 572418003854 ABC-ATPase subunit interface; other site 572418003855 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 572418003856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418003857 dimer interface [polypeptide binding]; other site 572418003858 conserved gate region; other site 572418003859 putative PBP binding loops; other site 572418003860 ABC-ATPase subunit interface; other site 572418003862 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 572418003863 active site clefts [active] 572418003864 zinc binding site [ion binding]; other site 572418003865 dimer interface [polypeptide binding]; other site 572418003866 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 572418003867 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 572418003868 Active Sites [active] 572418003869 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 572418003870 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 572418003871 CysD dimerization site [polypeptide binding]; other site 572418003872 G1 box; other site 572418003873 putative GEF interaction site [polypeptide binding]; other site 572418003874 GTP/Mg2+ binding site [chemical binding]; other site 572418003875 Switch I region; other site 572418003876 G2 box; other site 572418003877 G3 box; other site 572418003878 Switch II region; other site 572418003879 G4 box; other site 572418003880 G5 box; other site 572418003881 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 572418003882 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 572418003883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418003884 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 572418003885 Walker A/P-loop; other site 572418003886 ligand-binding site [chemical binding]; other site 572418003887 ATP binding site [chemical binding]; other site 572418003891 Rrf2 family protein; Region: rrf2_super; TIGR00738 572418003892 Transcriptional regulator; Region: Rrf2; pfam02082 572418003893 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572418003894 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 572418003895 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572418003896 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 572418003897 Putative esterase; Region: Esterase; pfam00756 572418003898 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 572418003899 Predicted membrane protein [Function unknown]; Region: COG4325 572418003900 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 572418003901 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418003902 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 572418003903 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 572418003904 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 572418003905 active site 572418003906 HIGH motif; other site 572418003907 KMSK motif region; other site 572418003908 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 572418003909 tRNA binding surface [nucleotide binding]; other site 572418003910 anticodon binding site; other site 572418003912 diaminopimelate decarboxylase; Region: lysA; TIGR01048 572418003913 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 572418003914 active site 572418003915 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572418003916 substrate binding site [chemical binding]; other site 572418003917 catalytic residues [active] 572418003918 dimer interface [polypeptide binding]; other site 572418003921 homoserine dehydrogenase; Provisional; Region: PRK06349 572418003922 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 572418003923 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 572418003924 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 572418003927 threonine synthase; Reviewed; Region: PRK06721 572418003928 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 572418003929 homodimer interface [polypeptide binding]; other site 572418003930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418003931 catalytic residue [active] 572418003933 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 572418003937 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 572418003939 peptide chain release factor 1; Region: prfA; TIGR00019 572418003940 This domain is found in peptide chain release factors; Region: PCRF; smart00937 572418003941 RF-1 domain; Region: RF-1; pfam00472 572418003943 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 572418003944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418003945 S-adenosylmethionine binding site [chemical binding]; other site 572418003946 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 572418003948 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 572418003949 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 572418003950 Mg++ binding site [ion binding]; other site 572418003951 putative catalytic motif [active] 572418003952 substrate binding site [chemical binding]; other site 572418003953 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 572418003954 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 572418003956 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 572418003958 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 572418003959 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 572418003960 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 572418003961 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 572418003962 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 572418003963 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 572418003964 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572418003965 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 572418003966 Walker A motif; other site 572418003967 ATP binding site [chemical binding]; other site 572418003968 Walker B motif; other site 572418003969 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572418003972 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 572418003973 core domain interface [polypeptide binding]; other site 572418003974 delta subunit interface [polypeptide binding]; other site 572418003975 epsilon subunit interface [polypeptide binding]; other site 572418003977 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 572418003978 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572418003979 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 572418003980 alpha subunit interaction interface [polypeptide binding]; other site 572418003981 Walker A motif; other site 572418003982 ATP binding site [chemical binding]; other site 572418003983 Walker B motif; other site 572418003984 inhibitor binding site; inhibition site 572418003985 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572418003988 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 572418003989 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 572418003990 gamma subunit interface [polypeptide binding]; other site 572418003991 epsilon subunit interface [polypeptide binding]; other site 572418003992 LBP interface [polypeptide binding]; other site 572418003993 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 572418003995 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 572418003996 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 572418003997 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 572418003998 hinge; other site 572418003999 active site 572418004000 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 572418004001 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 572418004002 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 572418004003 DNA binding site [nucleotide binding] 572418004004 active site 572418004006 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 572418004007 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 572418004008 AlkA N-terminal domain; Region: AlkA_N; pfam06029 572418004009 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 572418004010 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572418004011 minor groove reading motif; other site 572418004012 helix-hairpin-helix signature motif; other site 572418004013 substrate binding pocket [chemical binding]; other site 572418004014 active site 572418004016 HAMP domain; Region: HAMP; pfam00672 572418004017 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418004018 cyclase homology domain; Region: CHD; cd07302 572418004019 nucleotidyl binding site; other site 572418004020 metal binding site [ion binding]; metal-binding site 572418004021 dimer interface [polypeptide binding]; other site 572418004022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418004023 dimerization interface [polypeptide binding]; other site 572418004024 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418004025 cyclase homology domain; Region: CHD; cd07302 572418004026 nucleotidyl binding site; other site 572418004027 metal binding site [ion binding]; metal-binding site 572418004028 dimer interface [polypeptide binding]; other site 572418004029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418004030 dimerization interface [polypeptide binding]; other site 572418004031 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418004032 cyclase homology domain; Region: CHD; cd07302 572418004033 nucleotidyl binding site; other site 572418004034 metal binding site [ion binding]; metal-binding site 572418004035 dimer interface [polypeptide binding]; other site 572418004036 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 572418004037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418004038 dimerization interface [polypeptide binding]; other site 572418004039 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418004040 cyclase homology domain; Region: CHD; cd07302 572418004041 nucleotidyl binding site; other site 572418004042 metal binding site [ion binding]; metal-binding site 572418004043 dimer interface [polypeptide binding]; other site 572418004044 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 572418004045 hypothetical protein; Provisional; Region: PRK03298 572418004046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418004047 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 572418004048 dimer interface [polypeptide binding]; other site 572418004049 substrate binding site [chemical binding]; other site 572418004050 metal binding site [ion binding]; metal-binding site 572418004051 putative acyltransferase; Provisional; Region: PRK05790 572418004052 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572418004053 dimer interface [polypeptide binding]; other site 572418004054 active site 572418004058 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 572418004059 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 572418004061 PE family; Region: PE; pfam00934 572418004062 glycogen branching enzyme; Provisional; Region: PRK05402 572418004063 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 572418004064 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 572418004065 active site 572418004066 catalytic site [active] 572418004067 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 572418004068 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 572418004069 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 572418004070 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 572418004071 active site 572418004072 homodimer interface [polypeptide binding]; other site 572418004073 catalytic site [active] 572418004074 acceptor binding site [chemical binding]; other site 572418004075 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 572418004076 putative homodimer interface [polypeptide binding]; other site 572418004077 putative active site pocket [active] 572418004078 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 572418004079 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 572418004080 DEAD/DEAH box helicase; Region: DEAD; pfam00270 572418004081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572418004082 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 572418004084 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 572418004085 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 572418004086 active site 572418004087 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 572418004088 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 572418004089 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 572418004090 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 572418004091 putative active site pocket [active] 572418004092 cleavage site 572418004093 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 572418004094 MPN+ (JAMM) motif; other site 572418004095 Zinc-binding site [ion binding]; other site 572418004096 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572418004097 MoaE interaction surface [polypeptide binding]; other site 572418004098 MoeB interaction surface [polypeptide binding]; other site 572418004099 thiocarboxylated glycine; other site 572418004100 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 572418004101 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572418004102 dimer interface [polypeptide binding]; other site 572418004103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418004104 catalytic residue [active] 572418004106 Rhomboid family; Region: Rhomboid; pfam01694 572418004107 glutamate racemase; Provisional; Region: PRK00865 572418004109 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 572418004110 ribonuclease PH; Reviewed; Region: rph; PRK00173 572418004111 Ribonuclease PH; Region: RNase_PH_bact; cd11362 572418004112 hexamer interface [polypeptide binding]; other site 572418004113 active site 572418004114 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 572418004115 active site 572418004116 dimerization interface [polypeptide binding]; other site 572418004117 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 572418004118 Glucitol operon activator [Transcription]; Region: GutM; COG4578 572418004119 acyl carrier protein; Validated; Region: PRK05883 572418004120 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 572418004121 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418004122 acyl-activating enzyme (AAE) consensus motif; other site 572418004123 active site 572418004124 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418004125 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418004126 active site 572418004127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 572418004128 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 572418004129 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 572418004130 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 572418004131 FAD binding pocket [chemical binding]; other site 572418004132 FAD binding motif [chemical binding]; other site 572418004133 phosphate binding motif [ion binding]; other site 572418004134 NAD binding pocket [chemical binding]; other site 572418004135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418004136 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 572418004137 Walker A/P-loop; other site 572418004138 ATP binding site [chemical binding]; other site 572418004139 Q-loop/lid; other site 572418004140 ABC transporter signature motif; other site 572418004141 Walker B; other site 572418004142 D-loop; other site 572418004143 H-loop/switch region; other site 572418004146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418004147 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572418004148 Walker A/P-loop; other site 572418004149 ATP binding site [chemical binding]; other site 572418004150 Q-loop/lid; other site 572418004151 ABC transporter signature motif; other site 572418004152 Walker B; other site 572418004153 D-loop; other site 572418004154 H-loop/switch region; other site 572418004157 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 572418004158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418004159 NAD(P) binding site [chemical binding]; other site 572418004160 active site 572418004162 tetracycline repressor protein TetR; Provisional; Region: PRK13756 572418004163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418004164 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 572418004165 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572418004166 GAF domain; Region: GAF; pfam01590 572418004167 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 572418004168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 572418004169 metal binding site [ion binding]; metal-binding site 572418004170 active site 572418004171 I-site; other site 572418004172 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572418004173 hypothetical protein; Provisional; Region: PRK07877 572418004174 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 572418004175 ATP binding site [chemical binding]; other site 572418004176 substrate interface [chemical binding]; other site 572418004177 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 572418004178 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 572418004179 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418004180 cyclase homology domain; Region: CHD; cd07302 572418004181 nucleotidyl binding site; other site 572418004182 dimer interface [polypeptide binding]; other site 572418004183 metal binding site [ion binding]; metal-binding site 572418004184 AAA ATPase domain; Region: AAA_16; pfam13191 572418004185 Predicted ATPase [General function prediction only]; Region: COG3903 572418004186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572418004187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572418004188 DNA binding residues [nucleotide binding] 572418004189 dimerization interface [polypeptide binding]; other site 572418004192 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418004193 cyclase homology domain; Region: CHD; cd07302 572418004194 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 572418004195 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418004196 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418004197 PPE family; Region: PPE; pfam00823 572418004198 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418004200 PAS fold; Region: PAS_4; pfam08448 572418004201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 572418004202 putative active site [active] 572418004203 heme pocket [chemical binding]; other site 572418004204 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 572418004205 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 572418004206 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 572418004207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 572418004208 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572418004209 anti sigma factor interaction site; other site 572418004210 regulatory phosphorylation site [posttranslational modification]; other site 572418004211 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572418004212 anti sigma factor interaction site; other site 572418004213 regulatory phosphorylation site [posttranslational modification]; other site 572418004214 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 572418004215 synthetase active site [active] 572418004216 NTP binding site [chemical binding]; other site 572418004217 metal binding site [ion binding]; metal-binding site 572418004218 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418004219 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418004220 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 572418004221 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 572418004222 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 572418004223 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 572418004224 putative di-iron ligands [ion binding]; other site 572418004225 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 572418004226 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 572418004227 malonyl-CoA binding site [chemical binding]; other site 572418004228 dimer interface [polypeptide binding]; other site 572418004229 active site 572418004230 product binding site; other site 572418004231 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 572418004232 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 572418004233 uncharacterized domain; Region: TIGR00702 572418004234 YcaO-like family; Region: YcaO; pfam02624 572418004235 Uncharacterized conserved protein [Function unknown]; Region: COG3482 572418004236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418004237 S-adenosylmethionine binding site [chemical binding]; other site 572418004238 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418004239 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418004240 active site 572418004241 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 572418004242 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 572418004243 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 572418004244 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 572418004245 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 572418004247 dihydroorotase; Validated; Region: pyrC; PRK09357 572418004248 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572418004249 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 572418004250 active site 572418004252 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 572418004253 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 572418004254 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 572418004255 catalytic site [active] 572418004256 subunit interface [polypeptide binding]; other site 572418004258 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 572418004259 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572418004260 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572418004261 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 572418004262 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572418004263 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572418004264 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 572418004265 IMP binding site; other site 572418004266 dimer interface [polypeptide binding]; other site 572418004267 interdomain contacts; other site 572418004268 partial ornithine binding site; other site 572418004272 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 572418004273 active site 572418004274 dimer interface [polypeptide binding]; other site 572418004276 PE family; Region: PE; pfam00934 572418004277 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418004278 PPE family; Region: PPE; pfam00823 572418004279 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 572418004280 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 572418004281 catalytic site [active] 572418004282 G-X2-G-X-G-K; other site 572418004285 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 572418004286 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 572418004287 Flavoprotein; Region: Flavoprotein; pfam02441 572418004288 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 572418004289 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 572418004290 S-adenosylmethionine synthetase; Validated; Region: PRK05250 572418004291 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 572418004292 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 572418004294 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418004295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572418004296 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418004297 Cytochrome P450; Region: p450; cl12078 572418004299 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 572418004300 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572418004301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572418004302 PE family; Region: PE; pfam00934 572418004304 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572418004305 oligomeric interface; other site 572418004306 putative active site [active] 572418004307 homodimer interface [polypeptide binding]; other site 572418004308 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418004309 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418004310 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418004311 substrate binding pocket [chemical binding]; other site 572418004312 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418004313 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418004314 substrate binding pocket [chemical binding]; other site 572418004315 Predicted membrane protein [Function unknown]; Region: COG3714 572418004316 primosome assembly protein PriA; Provisional; Region: PRK14873 572418004317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418004318 S-adenosylmethionine binding site [chemical binding]; other site 572418004319 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572418004320 MarR family; Region: MarR; pfam01047 572418004321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418004322 S-adenosylmethionine binding site [chemical binding]; other site 572418004323 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 572418004324 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 572418004325 putative active site [active] 572418004326 substrate binding site [chemical binding]; other site 572418004327 putative cosubstrate binding site; other site 572418004328 catalytic site [active] 572418004329 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 572418004330 substrate binding site [chemical binding]; other site 572418004331 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 572418004332 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 572418004333 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 572418004334 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 572418004335 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 572418004336 substrate binding site [chemical binding]; other site 572418004337 hexamer interface [polypeptide binding]; other site 572418004338 metal binding site [ion binding]; metal-binding site 572418004341 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 572418004342 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 572418004343 catalytic motif [active] 572418004344 Zn binding site [ion binding]; other site 572418004345 RibD C-terminal domain; Region: RibD_C; pfam01872 572418004347 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572418004348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418004349 putative substrate translocation pore; other site 572418004351 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 572418004352 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 572418004353 Lumazine binding domain; Region: Lum_binding; pfam00677 572418004354 Lumazine binding domain; Region: Lum_binding; pfam00677 572418004357 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 572418004358 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 572418004359 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 572418004360 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 572418004361 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 572418004362 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 572418004363 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 572418004364 dimerization interface [polypeptide binding]; other site 572418004365 active site 572418004366 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 572418004367 homopentamer interface [polypeptide binding]; other site 572418004368 active site 572418004369 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 572418004370 PknH-like extracellular domain; Region: PknH_C; pfam14032 572418004371 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 572418004372 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 572418004373 putative sugar binding sites [chemical binding]; other site 572418004374 Q-X-W motif; other site 572418004375 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 572418004376 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 572418004377 GIY-YIG motif/motif A; other site 572418004378 active site 572418004379 catalytic site [active] 572418004380 putative DNA binding site [nucleotide binding]; other site 572418004381 metal binding site [ion binding]; metal-binding site 572418004382 UvrB/uvrC motif; Region: UVR; pfam02151 572418004383 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 572418004384 Helix-hairpin-helix motif; Region: HHH; pfam00633 572418004385 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 572418004386 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 572418004387 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 572418004388 phosphate binding site [ion binding]; other site 572418004389 putative substrate binding pocket [chemical binding]; other site 572418004390 dimer interface [polypeptide binding]; other site 572418004391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 572418004392 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 572418004394 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418004395 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418004396 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418004397 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572418004398 acyl-CoA synthetase; Provisional; Region: PRK13382 572418004399 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 572418004400 acyl-activating enzyme (AAE) consensus motif; other site 572418004401 putative AMP binding site [chemical binding]; other site 572418004402 putative active site [active] 572418004403 putative CoA binding site [chemical binding]; other site 572418004405 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418004406 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 572418004407 putative acyl-acceptor binding pocket; other site 572418004408 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 572418004409 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572418004410 PE family; Region: PE; pfam00934 572418004411 PE-PPE domain; Region: PE-PPE; pfam08237 572418004412 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 572418004413 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 572418004414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418004415 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 572418004416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572418004417 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572418004418 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 572418004419 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 572418004420 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 572418004422 Phosphoglycerate kinase; Region: PGK; pfam00162 572418004423 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 572418004424 substrate binding site [chemical binding]; other site 572418004425 hinge regions; other site 572418004426 ADP binding site [chemical binding]; other site 572418004427 catalytic site [active] 572418004429 triosephosphate isomerase; Provisional; Region: PRK14567 572418004430 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 572418004431 substrate binding site [chemical binding]; other site 572418004432 dimer interface [polypeptide binding]; other site 572418004433 catalytic triad [active] 572418004435 SnoaL-like domain; Region: SnoaL_2; pfam12680 572418004436 Preprotein translocase SecG subunit; Region: SecG; cl09123 572418004437 PE family; Region: PE; pfam00934 572418004438 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 572418004439 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 572418004440 molybdopterin cofactor binding site [chemical binding]; other site 572418004441 substrate binding site [chemical binding]; other site 572418004442 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 572418004443 molybdopterin cofactor binding site; other site 572418004444 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 572418004445 hydrophobic ligand binding site; other site 572418004446 Proteins of 100 residues with WXG; Region: WXG100; cl02005 572418004447 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 572418004448 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 572418004449 putative active site [active] 572418004450 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 572418004451 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 572418004452 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 572418004453 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 572418004454 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 572418004456 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 572418004457 putative active site [active] 572418004458 transaldolase; Provisional; Region: PRK03903 572418004459 catalytic residue [active] 572418004460 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 572418004461 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 572418004462 TPP-binding site [chemical binding]; other site 572418004463 dimer interface [polypeptide binding]; other site 572418004464 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572418004465 PYR/PP interface [polypeptide binding]; other site 572418004466 dimer interface [polypeptide binding]; other site 572418004467 TPP binding site [chemical binding]; other site 572418004469 PE family; Region: PE; pfam00934 572418004470 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 572418004471 UbiA prenyltransferase family; Region: UbiA; pfam01040 572418004472 PE family; Region: PE; pfam00934 572418004473 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 572418004474 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572418004475 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 572418004476 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 572418004477 NADP binding site [chemical binding]; other site 572418004478 dimer interface [polypeptide binding]; other site 572418004480 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 572418004481 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 572418004482 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 572418004483 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 572418004484 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572418004485 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572418004486 Walker A/P-loop; other site 572418004487 ATP binding site [chemical binding]; other site 572418004488 Q-loop/lid; other site 572418004489 ABC transporter signature motif; other site 572418004490 Walker B; other site 572418004491 D-loop; other site 572418004492 H-loop/switch region; other site 572418004495 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 572418004496 Predicted transcriptional regulator [Transcription]; Region: COG2345 572418004497 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418004498 putative DNA binding site [nucleotide binding]; other site 572418004499 putative Zn2+ binding site [ion binding]; other site 572418004500 Transcriptional regulator PadR-like family; Region: PadR; cl17335 572418004501 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 572418004502 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572418004503 protein-splicing catalytic site; other site 572418004504 thioester formation/cholesterol transfer; other site 572418004505 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 572418004506 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 572418004507 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 572418004508 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 572418004509 FeS assembly protein SufD; Region: sufD; TIGR01981 572418004510 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 572418004511 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 572418004512 Walker A/P-loop; other site 572418004513 ATP binding site [chemical binding]; other site 572418004514 Q-loop/lid; other site 572418004515 ABC transporter signature motif; other site 572418004516 Walker B; other site 572418004517 D-loop; other site 572418004518 H-loop/switch region; other site 572418004520 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 572418004521 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 572418004522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418004523 catalytic residue [active] 572418004525 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 572418004526 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 572418004527 trimerization site [polypeptide binding]; other site 572418004528 active site 572418004529 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 572418004530 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 572418004531 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 572418004532 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418004533 active site 572418004534 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 572418004535 PE family; Region: PE; pfam00934 572418004536 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 572418004537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418004539 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572418004540 catalytic residues [active] 572418004541 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572418004542 catalytic residues [active] 572418004544 enoyl-CoA hydratase; Provisional; Region: PRK05864 572418004545 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418004546 substrate binding site [chemical binding]; other site 572418004547 oxyanion hole (OAH) forming residues; other site 572418004548 trimer interface [polypeptide binding]; other site 572418004550 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572418004551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418004552 Walker A/P-loop; other site 572418004553 ATP binding site [chemical binding]; other site 572418004554 Q-loop/lid; other site 572418004555 ABC transporter signature motif; other site 572418004556 Walker B; other site 572418004557 D-loop; other site 572418004558 H-loop/switch region; other site 572418004559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572418004564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418004565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418004566 aconitate hydratase; Validated; Region: PRK09277 572418004567 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 572418004568 substrate binding site [chemical binding]; other site 572418004569 ligand binding site [chemical binding]; other site 572418004570 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 572418004571 substrate binding site [chemical binding]; other site 572418004572 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572418004573 NlpC/P60 family; Region: NLPC_P60; pfam00877 572418004574 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572418004575 NlpC/P60 family; Region: NLPC_P60; pfam00877 572418004576 MoxR-like ATPases [General function prediction only]; Region: COG0714 572418004577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418004578 Walker A motif; other site 572418004579 ATP binding site [chemical binding]; other site 572418004580 Walker B motif; other site 572418004581 arginine finger; other site 572418004582 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 572418004583 Protein of unknown function DUF58; Region: DUF58; pfam01882 572418004584 hypothetical protein; Provisional; Region: PRK13685 572418004585 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 572418004586 metal ion-dependent adhesion site (MIDAS); other site 572418004587 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 572418004588 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 572418004589 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 572418004590 NAD(P) binding site [chemical binding]; other site 572418004591 homotetramer interface [polypeptide binding]; other site 572418004592 homodimer interface [polypeptide binding]; other site 572418004593 active site 572418004595 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 572418004596 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 572418004597 NAD binding site [chemical binding]; other site 572418004598 homotetramer interface [polypeptide binding]; other site 572418004599 homodimer interface [polypeptide binding]; other site 572418004600 substrate binding site [chemical binding]; other site 572418004601 active site 572418004602 ferrochelatase; Reviewed; Region: hemH; PRK00035 572418004603 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 572418004604 C-terminal domain interface [polypeptide binding]; other site 572418004605 active site 572418004606 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 572418004607 active site 572418004608 N-terminal domain interface [polypeptide binding]; other site 572418004609 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 572418004610 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 572418004611 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 572418004612 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 572418004613 Uncharacterized conserved protein [Function unknown]; Region: COG0398 572418004614 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572418004615 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 572418004616 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 572418004617 heterodimer interface [polypeptide binding]; other site 572418004618 substrate interaction site [chemical binding]; other site 572418004619 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 572418004622 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 572418004623 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 572418004624 active site 572418004625 substrate binding site [chemical binding]; other site 572418004626 coenzyme B12 binding site [chemical binding]; other site 572418004627 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 572418004628 B12 binding site [chemical binding]; other site 572418004629 cobalt ligand [ion binding]; other site 572418004631 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 572418004632 membrane ATPase/protein kinase; Provisional; Region: PRK09435 572418004633 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 572418004634 Walker A; other site 572418004635 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418004636 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418004637 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572418004638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418004639 S-adenosylmethionine binding site [chemical binding]; other site 572418004641 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 572418004642 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 572418004643 Ligand binding site; other site 572418004644 Putative Catalytic site; other site 572418004645 DXD motif; other site 572418004646 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 572418004647 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 572418004648 active site 572418004649 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572418004650 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 572418004651 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 572418004652 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 572418004653 inhibitor-cofactor binding pocket; inhibition site 572418004654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418004655 catalytic residue [active] 572418004656 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 572418004657 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 572418004658 putative trimer interface [polypeptide binding]; other site 572418004659 putative CoA binding site [chemical binding]; other site 572418004660 Methyltransferase domain; Region: Methyltransf_12; pfam08242 572418004661 S-adenosylmethionine binding site [chemical binding]; other site 572418004662 WbqC-like protein family; Region: WbqC; pfam08889 572418004663 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 572418004664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418004665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418004666 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572418004667 Methyltransferase domain; Region: Methyltransf_12; pfam08242 572418004668 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 572418004669 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 572418004670 NADP-binding site; other site 572418004671 homotetramer interface [polypeptide binding]; other site 572418004672 substrate binding site [chemical binding]; other site 572418004673 homodimer interface [polypeptide binding]; other site 572418004674 active site 572418004675 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 572418004676 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 572418004677 NADP binding site [chemical binding]; other site 572418004678 active site 572418004679 putative substrate binding site [chemical binding]; other site 572418004680 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 572418004681 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 572418004682 metal-binding site 572418004683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418004684 S-adenosylmethionine binding site [chemical binding]; other site 572418004685 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572418004686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572418004687 active site 572418004688 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 572418004689 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572418004690 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 572418004691 active site 572418004692 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 572418004693 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572418004694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572418004695 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572418004696 active site 572418004697 acyl-CoA synthetase; Validated; Region: PRK05850 572418004698 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418004699 acyl-activating enzyme (AAE) consensus motif; other site 572418004700 active site 572418004702 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572418004703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418004704 S-adenosylmethionine binding site [chemical binding]; other site 572418004705 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 572418004706 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 572418004707 homodimer interface [polypeptide binding]; other site 572418004708 active site 572418004709 TDP-binding site; other site 572418004710 acceptor substrate-binding pocket; other site 572418004711 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 572418004712 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 572418004713 Probable Catalytic site; other site 572418004714 metal-binding site 572418004715 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 572418004716 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 572418004717 homodimer interface [polypeptide binding]; other site 572418004718 active site 572418004719 TDP-binding site; other site 572418004720 acceptor substrate-binding pocket; other site 572418004721 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418004722 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418004723 active site 572418004724 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 572418004725 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418004726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418004727 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 572418004728 Enoylreductase; Region: PKS_ER; smart00829 572418004729 NAD(P) binding site [chemical binding]; other site 572418004730 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 572418004731 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 572418004732 putative NADP binding site [chemical binding]; other site 572418004733 active site 572418004734 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418004735 acyl-CoA synthetase; Validated; Region: PRK05850 572418004736 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418004737 acyl-activating enzyme (AAE) consensus motif; other site 572418004738 active site 572418004739 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 572418004740 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572418004741 NAD(P) binding site [chemical binding]; other site 572418004743 Uncharacterized conserved protein [Function unknown]; Region: COG2128 572418004744 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 572418004745 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 572418004746 CoenzymeA binding site [chemical binding]; other site 572418004747 subunit interaction site [polypeptide binding]; other site 572418004748 PHB binding site; other site 572418004749 Nitronate monooxygenase; Region: NMO; pfam03060 572418004750 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 572418004751 FMN binding site [chemical binding]; other site 572418004752 substrate binding site [chemical binding]; other site 572418004753 putative catalytic residue [active] 572418004754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418004756 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 572418004757 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 572418004758 HIGH motif; other site 572418004759 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 572418004760 active site 572418004761 KMSKS motif; other site 572418004762 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 572418004763 tRNA binding surface [nucleotide binding]; other site 572418004764 anticodon binding site; other site 572418004766 DNA polymerase IV; Provisional; Region: PRK03348 572418004767 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 572418004768 active site 572418004769 DNA binding site [nucleotide binding] 572418004770 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 572418004771 active site 572418004772 homodimer interface [polypeptide binding]; other site 572418004773 homotetramer interface [polypeptide binding]; other site 572418004775 lipoprotein signal peptidase; Provisional; Region: PRK14764 572418004776 lipoprotein signal peptidase; Provisional; Region: PRK14787 572418004777 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 572418004778 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 572418004779 active site 572418004781 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 572418004782 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 572418004783 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 572418004784 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 572418004785 apolar tunnel; other site 572418004786 heme binding site [chemical binding]; other site 572418004787 dimerization interface [polypeptide binding]; other site 572418004788 short chain dehydrogenase; Provisional; Region: PRK05866 572418004789 classical (c) SDRs; Region: SDR_c; cd05233 572418004790 NAD(P) binding site [chemical binding]; other site 572418004791 active site 572418004792 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 572418004793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418004794 NAD(P) binding site [chemical binding]; other site 572418004795 active site 572418004797 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 572418004798 hydrophobic ligand binding site; other site 572418004799 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 572418004800 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 572418004801 active site 572418004802 PHP Thumb interface [polypeptide binding]; other site 572418004803 metal binding site [ion binding]; metal-binding site 572418004804 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 572418004805 generic binding surface II; other site 572418004806 generic binding surface I; other site 572418004807 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418004808 PPE family; Region: PPE; pfam00823 572418004809 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418004810 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418004811 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 572418004812 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 572418004813 acyl-activating enzyme (AAE) consensus motif; other site 572418004814 putative AMP binding site [chemical binding]; other site 572418004815 putative active site [active] 572418004816 putative CoA binding site [chemical binding]; other site 572418004818 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 572418004819 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 572418004820 putative acyl-acceptor binding pocket; other site 572418004821 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 572418004822 L-aspartate oxidase; Provisional; Region: PRK06175 572418004823 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572418004825 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 572418004826 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 572418004828 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 572418004829 D-subunit interface [polypeptide binding]; other site 572418004830 Iron-sulfur protein interface; other site 572418004831 proximal quinone binding site [chemical binding]; other site 572418004832 distal quinone binding site [chemical binding]; other site 572418004833 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 572418004834 Iron-sulfur protein interface; other site 572418004835 proximal quinone binding site [chemical binding]; other site 572418004836 C-subunit interface; other site 572418004837 distal quinone binding site; other site 572418004838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418004839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418004840 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 572418004841 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418004842 Domain of unknown function (DUF385); Region: DUF385; pfam04075 572418004843 threonine dehydratase; Validated; Region: PRK08639 572418004844 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 572418004845 tetramer interface [polypeptide binding]; other site 572418004846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418004847 catalytic residue [active] 572418004848 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 572418004850 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 572418004851 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 572418004852 putative active site [active] 572418004853 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 572418004854 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 572418004855 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 572418004856 catalytic site [active] 572418004857 active site 572418004858 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 572418004859 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 572418004860 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 572418004861 active site 572418004862 catalytic site [active] 572418004863 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 572418004864 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 572418004865 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 572418004866 active site 572418004867 catalytic site [active] 572418004868 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 572418004869 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572418004870 NlpC/P60 family; Region: NLPC_P60; pfam00877 572418004871 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 572418004872 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572418004873 inhibitor-cofactor binding pocket; inhibition site 572418004874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418004875 catalytic residue [active] 572418004877 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 572418004878 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 572418004879 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418004880 catalytic residue [active] 572418004882 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 572418004883 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 572418004884 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418004885 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418004886 active site 572418004887 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418004888 biotin synthase; Validated; Region: PRK06256 572418004889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418004890 FeS/SAM binding site; other site 572418004891 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 572418004892 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 572418004893 Secretory lipase; Region: LIP; pfam03583 572418004894 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 572418004895 nudix motif; other site 572418004896 quinolinate synthetase; Provisional; Region: PRK09375 572418004897 L-aspartate oxidase; Provisional; Region: PRK07804 572418004898 L-aspartate oxidase; Provisional; Region: PRK06175 572418004899 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572418004900 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 572418004901 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 572418004902 dimerization interface [polypeptide binding]; other site 572418004903 active site 572418004904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418004905 S-adenosylmethionine binding site [chemical binding]; other site 572418004906 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 572418004907 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 572418004908 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 572418004909 NAD binding site [chemical binding]; other site 572418004910 dimerization interface [polypeptide binding]; other site 572418004911 product binding site; other site 572418004912 substrate binding site [chemical binding]; other site 572418004913 zinc binding site [ion binding]; other site 572418004914 catalytic residues [active] 572418004916 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 572418004917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418004918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418004919 homodimer interface [polypeptide binding]; other site 572418004920 catalytic residue [active] 572418004922 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 572418004923 4-fold oligomerization interface [polypeptide binding]; other site 572418004924 putative active site pocket [active] 572418004925 metal binding residues [ion binding]; metal-binding site 572418004926 3-fold/trimer interface [polypeptide binding]; other site 572418004927 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 572418004928 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 572418004929 putative active site [active] 572418004930 oxyanion strand; other site 572418004931 catalytic triad [active] 572418004933 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 572418004934 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 572418004935 catalytic residues [active] 572418004936 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 572418004937 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 572418004938 active site 572418004939 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 572418004940 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 572418004941 substrate binding site [chemical binding]; other site 572418004942 glutamase interaction surface [polypeptide binding]; other site 572418004943 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 572418004944 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 572418004945 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 572418004946 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 572418004947 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 572418004948 catalytic triad [active] 572418004949 anthranilate synthase component I; Provisional; Region: PRK13571 572418004950 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 572418004951 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 572418004952 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 572418004953 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 572418004954 active site 572418004955 ribulose/triose binding site [chemical binding]; other site 572418004956 phosphate binding site [ion binding]; other site 572418004957 substrate (anthranilate) binding pocket [chemical binding]; other site 572418004958 product (indole) binding pocket [chemical binding]; other site 572418004960 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 572418004961 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 572418004962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418004963 catalytic residue [active] 572418004965 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 572418004966 substrate binding site [chemical binding]; other site 572418004967 active site 572418004968 catalytic residues [active] 572418004969 heterodimer interface [polypeptide binding]; other site 572418004970 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 572418004971 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 572418004972 TM2 domain; Region: TM2; pfam05154 572418004973 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 572418004975 pyruvate kinase; Provisional; Region: PRK06247 572418004976 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 572418004977 domain interfaces; other site 572418004978 active site 572418004979 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 572418004980 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 572418004981 active site 572418004982 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 572418004983 catalytic triad [active] 572418004984 dimer interface [polypeptide binding]; other site 572418004985 Uncharacterized conserved protein [Function unknown]; Region: COG2898 572418004986 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 572418004987 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 572418004988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418004989 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 572418004990 Walker A/P-loop; other site 572418004991 Walker A/P-loop; other site 572418004992 ATP binding site [chemical binding]; other site 572418004993 ATP binding site [chemical binding]; other site 572418004994 Q-loop/lid; other site 572418004997 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 572418004998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418004999 Walker A/P-loop; other site 572418005000 ATP binding site [chemical binding]; other site 572418005001 Q-loop/lid; other site 572418005002 ABC transporter signature motif; other site 572418005003 Walker B; other site 572418005004 D-loop; other site 572418005005 H-loop/switch region; other site 572418005008 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 572418005009 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 572418005010 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 572418005011 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 572418005012 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 572418005013 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 572418005014 cyclase homology domain; Region: CHD; cd07302 572418005015 nucleotidyl binding site; other site 572418005016 metal binding site [ion binding]; metal-binding site 572418005017 dimer interface [polypeptide binding]; other site 572418005018 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 572418005019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418005020 active site 572418005021 phosphorylation site [posttranslational modification] 572418005022 intermolecular recognition site; other site 572418005023 dimerization interface [polypeptide binding]; other site 572418005024 ANTAR domain; Region: ANTAR; pfam03861 572418005025 lipid-transfer protein; Provisional; Region: PRK06059 572418005026 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 572418005027 active site 572418005028 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 572418005029 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 572418005030 DUF35 OB-fold domain; Region: DUF35; pfam01796 572418005031 DNA polymerase I; Provisional; Region: PRK05755 572418005032 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 572418005033 active site 572418005034 metal binding site 1 [ion binding]; metal-binding site 572418005035 putative 5' ssDNA interaction site; other site 572418005036 metal binding site 3; metal-binding site 572418005037 metal binding site 2 [ion binding]; metal-binding site 572418005038 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 572418005039 putative DNA binding site [nucleotide binding]; other site 572418005040 putative metal binding site [ion binding]; other site 572418005041 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 572418005042 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 572418005043 active site 572418005044 DNA binding site [nucleotide binding] 572418005045 catalytic site [active] 572418005047 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 572418005048 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 572418005049 RNA binding site [nucleotide binding]; other site 572418005050 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 572418005051 RNA binding site [nucleotide binding]; other site 572418005052 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 572418005053 RNA binding site [nucleotide binding]; other site 572418005054 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 572418005055 RNA binding site [nucleotide binding]; other site 572418005056 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 572418005057 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 572418005058 CoA-binding site [chemical binding]; other site 572418005059 ATP-binding [chemical binding]; other site 572418005060 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 572418005062 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 572418005063 excinuclease ABC subunit B; Provisional; Region: PRK05298 572418005064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418005065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418005066 nucleotide binding region [chemical binding]; other site 572418005067 ATP-binding site [chemical binding]; other site 572418005068 Ultra-violet resistance protein B; Region: UvrB; pfam12344 572418005069 UvrB/uvrC motif; Region: UVR; pfam02151 572418005071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418005072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572418005073 putative substrate translocation pore; other site 572418005074 Predicted membrane protein [Function unknown]; Region: COG5305 572418005075 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418005076 Ligand Binding Site [chemical binding]; other site 572418005077 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 572418005078 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572418005079 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 572418005080 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 572418005085 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 572418005086 Predicted esterase [General function prediction only]; Region: COG0627 572418005088 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 572418005089 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 572418005090 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 572418005091 dimer interface [polypeptide binding]; other site 572418005092 putative anticodon binding site; other site 572418005093 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572418005094 motif 1; other site 572418005095 dimer interface [polypeptide binding]; other site 572418005096 active site 572418005097 motif 2; other site 572418005098 motif 3; other site 572418005101 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 572418005102 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 572418005103 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 572418005104 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 572418005105 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 572418005106 23S rRNA binding site [nucleotide binding]; other site 572418005107 L21 binding site [polypeptide binding]; other site 572418005108 L13 binding site [polypeptide binding]; other site 572418005110 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 572418005111 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572418005112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 572418005113 PE family; Region: PE; pfam00934 572418005114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418005115 cyclase homology domain; Region: CHD; cd07302 572418005116 nucleotidyl binding site; other site 572418005117 metal binding site [ion binding]; metal-binding site 572418005118 dimer interface [polypeptide binding]; other site 572418005119 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 572418005120 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 572418005121 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 572418005122 dimer interface [polypeptide binding]; other site 572418005123 motif 1; other site 572418005124 active site 572418005125 motif 2; other site 572418005126 motif 3; other site 572418005128 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 572418005129 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 572418005130 putative tRNA-binding site [nucleotide binding]; other site 572418005131 B3/4 domain; Region: B3_4; pfam03483 572418005132 tRNA synthetase B5 domain; Region: B5; smart00874 572418005133 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 572418005134 dimer interface [polypeptide binding]; other site 572418005135 motif 1; other site 572418005136 motif 3; other site 572418005137 motif 2; other site 572418005138 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 572418005139 PE family; Region: PE; pfam00934 572418005140 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 572418005141 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572418005142 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 572418005143 heterotetramer interface [polypeptide binding]; other site 572418005144 active site pocket [active] 572418005145 cleavage site 572418005146 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 572418005147 feedback inhibition sensing region; other site 572418005148 homohexameric interface [polypeptide binding]; other site 572418005149 nucleotide binding site [chemical binding]; other site 572418005150 N-acetyl-L-glutamate binding site [chemical binding]; other site 572418005151 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 572418005152 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572418005153 inhibitor-cofactor binding pocket; inhibition site 572418005154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418005155 catalytic residue [active] 572418005157 ornithine carbamoyltransferase; Provisional; Region: PRK00779 572418005158 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 572418005159 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 572418005161 arginine repressor; Provisional; Region: PRK03341 572418005162 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 572418005163 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 572418005164 argininosuccinate synthase; Provisional; Region: PRK13820 572418005165 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 572418005166 ANP binding site [chemical binding]; other site 572418005167 Substrate Binding Site II [chemical binding]; other site 572418005168 Substrate Binding Site I [chemical binding]; other site 572418005171 argininosuccinate lyase; Provisional; Region: PRK00855 572418005172 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 572418005173 active sites [active] 572418005174 tetramer interface [polypeptide binding]; other site 572418005177 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 572418005178 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 572418005179 malonyl-CoA binding site [chemical binding]; other site 572418005180 dimer interface [polypeptide binding]; other site 572418005181 active site 572418005182 product binding site; other site 572418005185 putative transposase OrfB; Reviewed; Region: PHA02517 572418005186 HTH-like domain; Region: HTH_21; pfam13276 572418005187 Integrase core domain; Region: rve; pfam00665 572418005188 Integrase core domain; Region: rve_3; pfam13683 572418005196 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 572418005197 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418005198 active site 572418005199 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572418005200 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418005201 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418005203 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 572418005204 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 572418005205 malonyl-CoA binding site [chemical binding]; other site 572418005206 dimer interface [polypeptide binding]; other site 572418005207 active site 572418005208 product binding site; other site 572418005209 Cytochrome P450; Region: p450; cl12078 572418005210 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418005212 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572418005213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572418005214 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572418005215 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 572418005216 ABC transporter; Region: ABC_tran_2; pfam12848 572418005217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572418005221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 572418005222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418005223 putative substrate translocation pore; other site 572418005224 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572418005225 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572418005226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418005227 dimerization interface [polypeptide binding]; other site 572418005228 putative DNA binding site [nucleotide binding]; other site 572418005229 putative Zn2+ binding site [ion binding]; other site 572418005230 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 572418005231 active site residue [active] 572418005233 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418005234 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418005235 ligand binding site [chemical binding]; other site 572418005236 flexible hinge region; other site 572418005237 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 572418005238 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 572418005239 putative catalytic residues [active] 572418005240 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 572418005241 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572418005242 catalytic residues [active] 572418005245 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418005246 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418005247 active site 572418005248 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 572418005249 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 572418005250 substrate binding pocket [chemical binding]; other site 572418005251 membrane-bound complex binding site; other site 572418005252 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 572418005253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418005254 FeS/SAM binding site; other site 572418005255 DivIVA protein; Region: DivIVA; pfam05103 572418005256 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 572418005257 acyl-CoA synthetase; Validated; Region: PRK07868 572418005258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418005259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418005260 acyl-activating enzyme (AAE) consensus motif; other site 572418005261 AMP binding site [chemical binding]; other site 572418005262 active site 572418005263 CoA binding site [chemical binding]; other site 572418005265 Uncharacterized conserved protein [Function unknown]; Region: COG2835 572418005266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418005267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418005268 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 572418005269 ABC-2 type transporter; Region: ABC2_membrane; cl17235 572418005270 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572418005271 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 572418005272 Walker A/P-loop; other site 572418005273 ATP binding site [chemical binding]; other site 572418005274 Q-loop/lid; other site 572418005275 ABC transporter signature motif; other site 572418005276 Walker B; other site 572418005277 D-loop; other site 572418005278 H-loop/switch region; other site 572418005282 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 572418005283 active site 572418005284 DNA binding site [nucleotide binding] 572418005285 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 572418005286 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 572418005287 active site 572418005288 HIGH motif; other site 572418005289 dimer interface [polypeptide binding]; other site 572418005290 KMSKS motif; other site 572418005291 S4 RNA-binding domain; Region: S4; smart00363 572418005292 RNA binding surface [nucleotide binding]; other site 572418005294 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418005296 Tetratrico peptide repeat; Region: TPR_5; pfam12688 572418005297 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 572418005298 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 572418005299 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 572418005300 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 572418005301 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572418005302 RNA binding surface [nucleotide binding]; other site 572418005303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418005304 S-adenosylmethionine binding site [chemical binding]; other site 572418005305 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 572418005306 ATP-NAD kinase; Region: NAD_kinase; pfam01513 572418005307 DNA repair protein RecN; Region: recN; TIGR00634 572418005308 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 572418005309 Walker A/P-loop; other site 572418005310 ATP binding site [chemical binding]; other site 572418005311 Q-loop/lid; other site 572418005312 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 572418005313 ABC transporter signature motif; other site 572418005314 Walker B; other site 572418005315 D-loop; other site 572418005316 H-loop/switch region; other site 572418005318 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 572418005319 Thiamine pyrophosphokinase; Region: TPK; cl08415 572418005320 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 572418005321 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 572418005322 CTP synthetase; Validated; Region: pyrG; PRK05380 572418005323 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 572418005324 Catalytic site [active] 572418005325 active site 572418005326 UTP binding site [chemical binding]; other site 572418005327 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 572418005328 active site 572418005329 putative oxyanion hole; other site 572418005330 catalytic triad [active] 572418005332 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 572418005333 dimer interface [polypeptide binding]; other site 572418005334 ADP-ribose binding site [chemical binding]; other site 572418005335 active site 572418005336 nudix motif; other site 572418005337 metal binding site [ion binding]; metal-binding site 572418005338 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 572418005339 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572418005340 active site 572418005341 DNA binding site [nucleotide binding] 572418005342 Int/Topo IB signature motif; other site 572418005343 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418005344 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418005345 active site 572418005346 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 572418005347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418005348 S-adenosylmethionine binding site [chemical binding]; other site 572418005349 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 572418005351 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005352 PPE family; Region: PPE; pfam00823 572418005353 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418005354 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005355 PPE family; Region: PPE; pfam00823 572418005356 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418005357 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 572418005358 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572418005359 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572418005360 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572418005361 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572418005362 P-loop; other site 572418005363 Magnesium ion binding site [ion binding]; other site 572418005364 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572418005365 Magnesium ion binding site [ion binding]; other site 572418005366 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 572418005367 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 572418005368 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 572418005369 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572418005370 RNA binding surface [nucleotide binding]; other site 572418005371 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 572418005372 active site 572418005374 cytidylate kinase; Provisional; Region: cmk; PRK00023 572418005375 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 572418005376 CMP-binding site; other site 572418005377 The sites determining sugar specificity; other site 572418005379 GTP-binding protein Der; Reviewed; Region: PRK03003 572418005380 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 572418005381 GTP/Mg2+ binding site [chemical binding]; other site 572418005382 Switch I region; other site 572418005383 G2 box; other site 572418005384 Switch II region; other site 572418005385 G3 box; other site 572418005386 G4 box; other site 572418005387 G5 box; other site 572418005388 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 572418005389 G1 box; other site 572418005390 GTP/Mg2+ binding site [chemical binding]; other site 572418005391 Switch I region; other site 572418005392 G2 box; other site 572418005393 G3 box; other site 572418005394 Switch II region; other site 572418005395 G4 box; other site 572418005396 G5 box; other site 572418005399 short chain dehydrogenase; Provisional; Region: PRK07060 572418005400 classical (c) SDRs; Region: SDR_c; cd05233 572418005401 NAD(P) binding site [chemical binding]; other site 572418005402 active site 572418005403 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 572418005404 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 572418005405 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 572418005406 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 572418005407 Cupin domain; Region: Cupin_2; pfam07883 572418005408 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 572418005409 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572418005410 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 572418005411 putative switch regulator; other site 572418005412 non-specific DNA interactions [nucleotide binding]; other site 572418005413 DNA binding site [nucleotide binding] 572418005414 sequence specific DNA binding site [nucleotide binding]; other site 572418005415 putative cAMP binding site [chemical binding]; other site 572418005416 Bacterial transcriptional regulator; Region: IclR; pfam01614 572418005417 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 572418005418 putative active site [active] 572418005419 homotetrameric interface [polypeptide binding]; other site 572418005420 metal binding site [ion binding]; metal-binding site 572418005421 biotin carboxylase-like protein; Validated; Region: PRK06524 572418005422 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572418005423 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418005424 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418005425 Predicted transcriptional regulators [Transcription]; Region: COG1733 572418005426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418005427 dimerization interface [polypeptide binding]; other site 572418005428 putative DNA binding site [nucleotide binding]; other site 572418005429 putative Zn2+ binding site [ion binding]; other site 572418005430 Predicted transcriptional regulators [Transcription]; Region: COG1733 572418005431 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418005432 FAD binding domain; Region: FAD_binding_4; pfam01565 572418005433 Berberine and berberine like; Region: BBE; pfam08031 572418005434 TIGR03086 family protein; Region: TIGR03086 572418005435 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 572418005436 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418005437 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418005438 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418005439 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418005440 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 572418005441 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 572418005442 NAD(P) binding site [chemical binding]; other site 572418005443 catalytic residues [active] 572418005446 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 572418005447 putative catalytic residue [active] 572418005448 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 572418005449 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572418005450 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 572418005451 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 572418005452 gating phenylalanine in ion channel; other site 572418005455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418005456 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 572418005457 putative substrate translocation pore; other site 572418005458 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 572418005459 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 572418005460 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 572418005461 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572418005462 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 572418005464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 572418005465 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 572418005466 putative active site [active] 572418005468 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 572418005469 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418005470 active site 572418005471 ATP binding site [chemical binding]; other site 572418005472 substrate binding site [chemical binding]; other site 572418005473 activation loop (A-loop); other site 572418005474 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 572418005475 Thioredoxin; Region: Thioredoxin_4; cl17273 572418005477 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 572418005478 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 572418005479 active site 572418005480 metal binding site [ion binding]; metal-binding site 572418005481 nudix motif; other site 572418005482 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418005483 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418005484 active site 572418005485 ATP binding site [chemical binding]; other site 572418005486 substrate binding site [chemical binding]; other site 572418005487 activation loop (A-loop); other site 572418005489 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418005490 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418005491 phosphopeptide binding site; other site 572418005492 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418005493 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418005494 phosphopeptide binding site; other site 572418005495 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 572418005496 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 572418005497 Walker A/P-loop; other site 572418005498 ATP binding site [chemical binding]; other site 572418005499 Q-loop/lid; other site 572418005500 ABC transporter signature motif; other site 572418005501 Walker B; other site 572418005502 D-loop; other site 572418005503 H-loop/switch region; other site 572418005504 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 572418005507 acyl-CoA synthetase; Provisional; Region: PRK13388 572418005508 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418005509 acyl-activating enzyme (AAE) consensus motif; other site 572418005510 AMP binding site [chemical binding]; other site 572418005511 active site 572418005512 CoA binding site [chemical binding]; other site 572418005514 hypothetical protein; Provisional; Region: PRK06185 572418005515 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 572418005516 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 572418005518 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 572418005519 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005520 PPE family; Region: PPE; pfam00823 572418005521 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418005522 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418005523 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 572418005525 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 572418005526 Phosphoesterase family; Region: Phosphoesterase; pfam04185 572418005527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572418005528 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 572418005529 sulfite oxidase; Provisional; Region: PLN00177 572418005530 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 572418005531 Moco binding site; other site 572418005532 metal coordination site [ion binding]; other site 572418005533 dimerization interface [polypeptide binding]; other site 572418005534 Transport protein; Region: actII; TIGR00833 572418005535 Cutinase; Region: Cutinase; pfam01083 572418005537 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418005538 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418005539 Uncharacterized conserved protein [Function unknown]; Region: COG0393 572418005540 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 572418005542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572418005543 Transposase; Region: HTH_Tnp_1; cl17663 572418005544 putative transposase OrfB; Reviewed; Region: PHA02517 572418005545 HTH-like domain; Region: HTH_21; pfam13276 572418005546 Integrase core domain; Region: rve; pfam00665 572418005547 Integrase core domain; Region: rve_3; pfam13683 572418005548 Integrase core domain; Region: rve; pfam00665 572418005549 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 572418005550 putative homotetramer interface [polypeptide binding]; other site 572418005551 putative homodimer interface [polypeptide binding]; other site 572418005552 putative allosteric switch controlling residues; other site 572418005553 putative metal binding site [ion binding]; other site 572418005554 putative homodimer-homodimer interface [polypeptide binding]; other site 572418005555 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 572418005556 PE family; Region: PE; pfam00934 572418005557 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 572418005558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 572418005559 dimer interface [polypeptide binding]; other site 572418005560 active site 572418005561 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572418005562 substrate binding site [chemical binding]; other site 572418005563 catalytic residue [active] 572418005564 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 572418005565 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 572418005566 metal binding site [ion binding]; metal-binding site 572418005567 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 572418005568 FAD binding domain; Region: FAD_binding_4; pfam01565 572418005569 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 572418005571 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 572418005572 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572418005573 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572418005574 Bacterial transcriptional regulator; Region: IclR; pfam01614 572418005575 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418005576 FAD binding domain; Region: FAD_binding_4; pfam01565 572418005578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418005579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418005580 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418005581 Cytochrome P450; Region: p450; cl12078 572418005583 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 572418005584 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 572418005585 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 572418005586 Protein of unknown function (DUF690); Region: DUF690; pfam05108 572418005587 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 572418005588 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418005589 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 572418005590 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418005593 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418005594 Cytochrome P450; Region: p450; cl12078 572418005596 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 572418005597 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005598 PPE family; Region: PPE; pfam00823 572418005599 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418005600 PE family; Region: PE; pfam00934 572418005601 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005602 PPE family; Region: PPE; pfam00823 572418005603 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418005604 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005605 PPE family; Region: PPE; pfam00823 572418005606 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418005607 PE family; Region: PE; pfam00934 572418005608 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572418005609 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 572418005610 EspG family; Region: ESX-1_EspG; pfam14011 572418005612 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 572418005613 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 572418005614 catalytic residues [active] 572418005615 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 572418005616 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 572418005617 active site 572418005618 catalytic residues [active] 572418005621 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 572418005622 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 572418005623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418005624 Walker A motif; other site 572418005625 ATP binding site [chemical binding]; other site 572418005626 Walker B motif; other site 572418005627 arginine finger; other site 572418005630 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005631 PPE family; Region: PPE; pfam00823 572418005632 PE-PPE domain; Region: PE-PPE; pfam08237 572418005633 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005634 PPE family; Region: PPE; pfam00823 572418005636 PE family; Region: PE; pfam00934 572418005639 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418005640 PE family; Region: PE; pfam00934 572418005641 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005642 PPE family; Region: PPE; pfam00823 572418005643 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005644 PPE family; Region: PPE; pfam00823 572418005645 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005646 PPE family; Region: PPE; pfam00823 572418005647 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418005648 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418005649 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 572418005650 MgtC family; Region: MgtC; pfam02308 572418005651 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 572418005652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418005653 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 572418005654 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 572418005655 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 572418005656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418005657 hypothetical protein; Validated; Region: PRK07121 572418005658 PE family; Region: PE; pfam00934 572418005661 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 572418005662 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 572418005663 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 572418005666 hypothetical protein; Provisional; Region: PRK05858 572418005667 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572418005668 PYR/PP interface [polypeptide binding]; other site 572418005669 dimer interface [polypeptide binding]; other site 572418005670 TPP binding site [chemical binding]; other site 572418005671 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572418005672 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 572418005673 TPP-binding site; other site 572418005674 dimer interface [polypeptide binding]; other site 572418005676 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 572418005677 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 572418005678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 572418005679 nucleotide binding region [chemical binding]; other site 572418005680 ATP-binding site [chemical binding]; other site 572418005681 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 572418005684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 572418005685 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 572418005686 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 572418005687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 572418005688 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 572418005689 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 572418005690 lipoyl attachment site [posttranslational modification]; other site 572418005692 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418005693 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418005694 phosphopeptide binding site; other site 572418005695 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 572418005696 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572418005697 DNA binding residues [nucleotide binding] 572418005698 Bifunctional nuclease; Region: DNase-RNase; pfam02577 572418005699 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 572418005700 DNA binding residues [nucleotide binding] 572418005701 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 572418005702 putative dimer interface [polypeptide binding]; other site 572418005703 glycine dehydrogenase; Provisional; Region: PRK05367 572418005704 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 572418005705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418005706 tetramer interface [polypeptide binding]; other site 572418005707 catalytic residue [active] 572418005708 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 572418005709 tetramer interface [polypeptide binding]; other site 572418005710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418005711 catalytic residue [active] 572418005712 haloalkane dehalogenase; Provisional; Region: PRK03204 572418005713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 572418005714 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 572418005715 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 572418005716 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 572418005717 metal ion-dependent adhesion site (MIDAS); other site 572418005719 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 572418005720 active site 572418005721 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 572418005722 putative active site [active] 572418005723 Domain of unknown function DUF21; Region: DUF21; pfam01595 572418005724 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572418005725 FOG: CBS domain [General function prediction only]; Region: COG0517 572418005726 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572418005727 Domain of unknown function DUF21; Region: DUF21; pfam01595 572418005728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572418005729 Transporter associated domain; Region: CorC_HlyC; smart01091 572418005730 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 572418005731 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572418005732 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 572418005733 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 572418005734 active site 572418005735 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 572418005736 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 572418005737 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 572418005738 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 572418005739 Predicted transcriptional regulator [Transcription]; Region: COG3682 572418005740 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 572418005741 CoenzymeA binding site [chemical binding]; other site 572418005742 subunit interaction site [polypeptide binding]; other site 572418005743 PHB binding site; other site 572418005744 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 572418005745 alpha-gamma subunit interface [polypeptide binding]; other site 572418005746 beta-gamma subunit interface [polypeptide binding]; other site 572418005747 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 572418005748 gamma-beta subunit interface [polypeptide binding]; other site 572418005749 alpha-beta subunit interface [polypeptide binding]; other site 572418005750 urease subunit alpha; Reviewed; Region: ureC; PRK13206 572418005751 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 572418005752 subunit interactions [polypeptide binding]; other site 572418005753 active site 572418005754 flap region; other site 572418005756 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 572418005757 UreF; Region: UreF; pfam01730 572418005758 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572418005760 UreD urease accessory protein; Region: UreD; cl00530 572418005761 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 572418005762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418005763 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 572418005764 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418005765 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418005767 classical (c) SDRs; Region: SDR_c; cd05233 572418005768 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 572418005769 NAD(P) binding site [chemical binding]; other site 572418005770 active site 572418005771 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 572418005772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 572418005774 sulfate transport protein; Provisional; Region: cysT; CHL00187 572418005775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418005776 dimer interface [polypeptide binding]; other site 572418005777 conserved gate region; other site 572418005778 putative PBP binding loops; other site 572418005779 ABC-ATPase subunit interface; other site 572418005780 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 572418005781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418005782 Walker A/P-loop; other site 572418005783 ATP binding site [chemical binding]; other site 572418005784 Q-loop/lid; other site 572418005785 ABC transporter signature motif; other site 572418005786 Walker B; other site 572418005787 D-loop; other site 572418005788 H-loop/switch region; other site 572418005789 TOBE domain; Region: TOBE; pfam03459 572418005792 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 572418005793 Predicted membrane protein [Function unknown]; Region: COG2261 572418005795 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 572418005796 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 572418005797 putative NAD(P) binding site [chemical binding]; other site 572418005798 putative substrate binding site [chemical binding]; other site 572418005799 catalytic Zn binding site [ion binding]; other site 572418005800 structural Zn binding site [ion binding]; other site 572418005802 CAAX protease self-immunity; Region: Abi; pfam02517 572418005803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 572418005804 MOSC domain; Region: MOSC; pfam03473 572418005805 short chain dehydrogenase; Provisional; Region: PRK07825 572418005806 classical (c) SDRs; Region: SDR_c; cd05233 572418005807 NAD(P) binding site [chemical binding]; other site 572418005808 active site 572418005810 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 572418005811 CoA-transferase family III; Region: CoA_transf_3; pfam02515 572418005812 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 572418005813 CoA-transferase family III; Region: CoA_transf_3; pfam02515 572418005814 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 572418005815 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 572418005816 active site 572418005817 hypothetical protein; Provisional; Region: PRK12320 572418005818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418005819 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 572418005820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418005821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418005822 Domain of unknown function (DUF385); Region: DUF385; pfam04075 572418005823 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 572418005824 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 572418005825 active site 572418005826 substrate binding site [chemical binding]; other site 572418005827 FMN binding site [chemical binding]; other site 572418005828 putative catalytic residues [active] 572418005830 Uncharacterized conserved protein [Function unknown]; Region: COG5579 572418005831 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 572418005832 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 572418005833 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 572418005834 heme binding site [chemical binding]; other site 572418005835 ferroxidase pore; other site 572418005836 ferroxidase diiron center [ion binding]; other site 572418005837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418005838 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572418005839 putative substrate translocation pore; other site 572418005840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418005841 putative substrate translocation pore; other site 572418005842 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 572418005843 23S rRNA interface [nucleotide binding]; other site 572418005844 L3 interface [polypeptide binding]; other site 572418005845 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572418005847 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 572418005848 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 572418005849 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 572418005850 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418005851 Cytochrome P450; Region: p450; cl12078 572418005853 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 572418005854 short chain dehydrogenase; Provisional; Region: PRK08267 572418005855 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 572418005856 putative NAD(P) binding site [chemical binding]; other site 572418005857 active site 572418005859 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 572418005860 hydrophobic ligand binding site; other site 572418005861 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 572418005862 chorismate mutase; Provisional; Region: PRK09269 572418005863 chorismate mutase, putative; Region: CM_mono2; TIGR01806 572418005864 Putative esterase; Region: Esterase; pfam00756 572418005866 Leucine carboxyl methyltransferase; Region: LCM; cl01306 572418005867 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418005868 Leucine carboxyl methyltransferase; Region: LCM; cl01306 572418005869 Uncharacterized conserved protein [Function unknown]; Region: COG2353 572418005870 Nitronate monooxygenase; Region: NMO; pfam03060 572418005871 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 572418005872 FMN binding site [chemical binding]; other site 572418005873 substrate binding site [chemical binding]; other site 572418005874 putative catalytic residue [active] 572418005876 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418005877 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418005878 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 572418005879 putative active site [active] 572418005880 dimerization interface [polypeptide binding]; other site 572418005881 putative tRNAtyr binding site [nucleotide binding]; other site 572418005882 Domain of unknown function DUF77; Region: DUF77; pfam01910 572418005883 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 572418005884 putative ADP-ribose binding site [chemical binding]; other site 572418005886 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418005887 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418005888 cyclase homology domain; Region: CHD; cd07302 572418005889 nucleotidyl binding site; other site 572418005890 metal binding site [ion binding]; metal-binding site 572418005891 dimer interface [polypeptide binding]; other site 572418005892 competence damage-inducible protein A; Provisional; Region: PRK00549 572418005893 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 572418005894 putative MPT binding site; other site 572418005895 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 572418005896 putative sialic acid transporter; Region: 2A0112; TIGR00891 572418005897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418005898 putative substrate translocation pore; other site 572418005900 Predicted membrane protein [Function unknown]; Region: COG1950 572418005901 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572418005902 anti sigma factor interaction site; other site 572418005903 regulatory phosphorylation site [posttranslational modification]; other site 572418005904 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 572418005905 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 572418005906 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 572418005907 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 572418005908 dimer interface [polypeptide binding]; other site 572418005909 active site 572418005910 heme binding site [chemical binding]; other site 572418005911 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 572418005914 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572418005915 metal binding site 2 [ion binding]; metal-binding site 572418005916 putative DNA binding helix; other site 572418005917 metal binding site 1 [ion binding]; metal-binding site 572418005918 dimer interface [polypeptide binding]; other site 572418005919 structural Zn2+ binding site [ion binding]; other site 572418005920 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 572418005921 substrate binding site [chemical binding]; other site 572418005922 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 572418005923 substrate binding site [chemical binding]; other site 572418005925 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572418005926 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 572418005927 putative NAD(P) binding site [chemical binding]; other site 572418005929 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572418005930 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572418005931 tetramer interface [polypeptide binding]; other site 572418005932 active site 572418005933 Mg2+/Mn2+ binding site [ion binding]; other site 572418005934 Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224 572418005935 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005936 PPE family; Region: PPE; pfam00823 572418005937 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005938 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418005939 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418005940 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005941 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418005942 PPE family; Region: PPE; pfam00823 572418005943 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418005944 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418005945 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 572418005946 putative hydrophobic ligand binding site [chemical binding]; other site 572418005947 protein interface [polypeptide binding]; other site 572418005948 gate; other site 572418005949 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418005950 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 572418005951 putative acyl-acceptor binding pocket; other site 572418005952 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572418005954 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418005955 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418005957 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418005958 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418005959 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 572418005960 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418005961 acyl-activating enzyme (AAE) consensus motif; other site 572418005962 active site 572418005963 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 572418005964 Uncharacterized conserved protein [Function unknown]; Region: COG3361 572418005965 short chain dehydrogenase; Provisional; Region: PRK05867 572418005966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418005967 NAD(P) binding site [chemical binding]; other site 572418005968 active site 572418005970 TIGR03085 family protein; Region: TIGR03085 572418005971 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 572418005972 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 572418005973 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 572418005974 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 572418005975 conserved cys residue [active] 572418005976 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572418005977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572418005978 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 572418005979 dimer interface [polypeptide binding]; other site 572418005980 catalytic triad [active] 572418005981 peroxidatic and resolving cysteines [active] 572418005982 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418005983 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 572418005984 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 572418005985 active site 572418005986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418005987 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 572418005988 FAD binding site [chemical binding]; other site 572418005989 substrate binding site [chemical binding]; other site 572418005990 catalytic base [active] 572418005991 enoyl-CoA hydratase; Provisional; Region: PRK08290 572418005992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418005993 substrate binding site [chemical binding]; other site 572418005994 oxyanion hole (OAH) forming residues; other site 572418005995 trimer interface [polypeptide binding]; other site 572418005996 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418005997 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 572418006000 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418006001 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572418006002 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 572418006003 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 572418006004 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 572418006005 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 572418006006 dimerization interface [polypeptide binding]; other site 572418006007 active site 572418006008 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 572418006009 putative NAD(P) binding site [chemical binding]; other site 572418006010 active site 572418006011 homodimer interface [polypeptide binding]; other site 572418006013 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 572418006014 SEC-C motif; Region: SEC-C; pfam02810 572418006015 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418006016 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418006017 active site 572418006019 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 572418006020 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 572418006021 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 572418006022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418006023 non-specific DNA binding site [nucleotide binding]; other site 572418006024 salt bridge; other site 572418006025 sequence-specific DNA binding site [nucleotide binding]; other site 572418006026 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 572418006027 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 572418006028 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 572418006029 putative active site [active] 572418006030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418006031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418006032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418006033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418006036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418006037 S-adenosylmethionine binding site [chemical binding]; other site 572418006038 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 572418006040 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 572418006041 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 572418006042 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 572418006043 dimer interface [polypeptide binding]; other site 572418006044 putative radical transfer pathway; other site 572418006045 diiron center [ion binding]; other site 572418006046 tyrosyl radical; other site 572418006048 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 572418006049 putative active site [active] 572418006050 PE family; Region: PE; pfam00934 572418006052 Cutinase; Region: Cutinase; pfam01083 572418006053 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 572418006054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572418006055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 572418006056 dimerization interface [polypeptide binding]; other site 572418006058 Lysine efflux permease [General function prediction only]; Region: COG1279 572418006059 Cellulose binding domain; Region: CBM_2; pfam00553 572418006060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418006061 S-adenosylmethionine binding site [chemical binding]; other site 572418006063 Uncharacterized conserved protein [Function unknown]; Region: COG5654 572418006064 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 572418006065 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 572418006066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418006067 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 572418006068 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 572418006069 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418006072 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 572418006073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418006074 dimerization interface [polypeptide binding]; other site 572418006075 putative DNA binding site [nucleotide binding]; other site 572418006076 putative Zn2+ binding site [ion binding]; other site 572418006078 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418006079 Ligand Binding Site [chemical binding]; other site 572418006080 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418006081 Ligand Binding Site [chemical binding]; other site 572418006082 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572418006083 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 572418006084 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418006085 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 572418006086 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572418006087 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572418006089 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 572418006090 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 572418006091 tetramer interface [polypeptide binding]; other site 572418006092 active site 572418006093 Mg2+/Mn2+ binding site [ion binding]; other site 572418006094 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 572418006095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572418006096 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 572418006097 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 572418006098 homotetramer interface [polypeptide binding]; other site 572418006099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 572418006100 NAD binding site [chemical binding]; other site 572418006101 homodimer interface [polypeptide binding]; other site 572418006102 active site 572418006104 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572418006105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418006106 S-adenosylmethionine binding site [chemical binding]; other site 572418006107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 572418006108 Predicted kinase [General function prediction only]; Region: COG0645 572418006109 AAA domain; Region: AAA_17; pfam13207 572418006111 Universal stress protein family; Region: Usp; pfam00582 572418006112 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418006113 Ligand Binding Site [chemical binding]; other site 572418006116 Ferredoxin [Energy production and conversion]; Region: COG1146 572418006117 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 572418006118 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 572418006119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418006120 Walker A motif; other site 572418006121 ATP binding site [chemical binding]; other site 572418006122 Walker B motif; other site 572418006123 arginine finger; other site 572418006126 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 572418006127 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 572418006128 putative active site [active] 572418006129 Transcriptional regulators [Transcription]; Region: MarR; COG1846 572418006130 MarR family; Region: MarR_2; pfam12802 572418006131 Phage envelope protein [General function prediction only]; Region: COG5562 572418006132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 572418006133 Transposase; Region: DEDD_Tnp_IS110; pfam01548 572418006134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 572418006135 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 572418006136 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418006137 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418006138 active site 572418006139 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572418006140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418006141 non-specific DNA binding site [nucleotide binding]; other site 572418006142 salt bridge; other site 572418006143 sequence-specific DNA binding site [nucleotide binding]; other site 572418006144 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 572418006146 Uncharacterized conserved protein [Function unknown]; Region: COG2442 572418006147 Predicted helicase [General function prediction only]; Region: COG4889 572418006148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418006149 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 572418006150 non-specific DNA binding site [nucleotide binding]; other site 572418006151 salt bridge; other site 572418006152 sequence-specific DNA binding site [nucleotide binding]; other site 572418006153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 572418006154 Predicted helicase [General function prediction only]; Region: COG4889 572418006155 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 572418006156 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 572418006157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418006158 ATP binding site [chemical binding]; other site 572418006159 putative Mg++ binding site [ion binding]; other site 572418006160 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 572418006161 ATP-binding site [chemical binding]; other site 572418006162 Methyltransferase domain; Region: Methyltransf_26; pfam13659 572418006163 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 572418006164 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 572418006165 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418006166 Ligand Binding Site [chemical binding]; other site 572418006167 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418006168 Ligand Binding Site [chemical binding]; other site 572418006169 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572418006170 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572418006171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572418006172 Histidine kinase; Region: HisKA_3; pfam07730 572418006173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418006174 Ligand Binding Site [chemical binding]; other site 572418006175 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 572418006176 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 572418006177 putative substrate binding site [chemical binding]; other site 572418006178 putative ATP binding site [chemical binding]; other site 572418006180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418006181 active site 572418006182 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 572418006183 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 572418006184 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 572418006185 putative dimer interface [polypeptide binding]; other site 572418006186 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 572418006187 dimer interface [polypeptide binding]; other site 572418006188 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 572418006189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418006190 putative DNA binding site [nucleotide binding]; other site 572418006191 dimerization interface [polypeptide binding]; other site 572418006192 putative Zn2+ binding site [ion binding]; other site 572418006193 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 572418006194 putative hydrophobic ligand binding site [chemical binding]; other site 572418006195 CLM binding site; other site 572418006196 L1 loop; other site 572418006197 DNA binding site [nucleotide binding] 572418006198 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 572418006199 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 572418006200 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 572418006201 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572418006202 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 572418006203 nucleophile elbow; other site 572418006204 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 572418006205 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 572418006206 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 572418006207 Walker A/P-loop; other site 572418006208 ATP binding site [chemical binding]; other site 572418006209 Q-loop/lid; other site 572418006210 ABC transporter signature motif; other site 572418006211 Walker B; other site 572418006212 D-loop; other site 572418006213 H-loop/switch region; other site 572418006214 TOBE domain; Region: TOBE_2; pfam08402 572418006217 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 572418006218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418006219 dimer interface [polypeptide binding]; other site 572418006220 conserved gate region; other site 572418006221 putative PBP binding loops; other site 572418006222 ABC-ATPase subunit interface; other site 572418006224 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 572418006225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418006226 dimer interface [polypeptide binding]; other site 572418006227 conserved gate region; other site 572418006228 putative PBP binding loops; other site 572418006229 ABC-ATPase subunit interface; other site 572418006231 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 572418006232 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 572418006234 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 572418006235 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 572418006236 Isochorismatase family; Region: Isochorismatase; pfam00857 572418006237 catalytic triad [active] 572418006238 metal binding site [ion binding]; metal-binding site 572418006239 conserved cis-peptide bond; other site 572418006240 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 572418006241 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 572418006242 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418006243 substrate binding pocket [chemical binding]; other site 572418006244 catalytic triad [active] 572418006248 hypothetical protein; Provisional; Region: PRK05865 572418006249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418006250 NAD(P) binding site [chemical binding]; other site 572418006251 active site 572418006252 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 572418006253 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418006254 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418006255 active site 572418006256 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418006257 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418006258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418006259 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 572418006260 Enoylreductase; Region: PKS_ER; smart00829 572418006261 NAD(P) binding site [chemical binding]; other site 572418006262 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 572418006263 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 572418006264 putative NADP binding site [chemical binding]; other site 572418006265 active site 572418006266 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418006267 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418006268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418006269 active site 572418006270 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418006271 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418006272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418006273 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 572418006274 Enoylreductase; Region: PKS_ER; smart00829 572418006275 NAD(P) binding site [chemical binding]; other site 572418006276 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 572418006277 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 572418006278 putative NADP binding site [chemical binding]; other site 572418006279 active site 572418006280 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418006285 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 572418006286 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 572418006287 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 572418006288 putative active site [active] 572418006289 catalytic triad [active] 572418006290 putative dimer interface [polypeptide binding]; other site 572418006291 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 572418006292 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 572418006293 Ligand binding site; other site 572418006294 Putative Catalytic site; other site 572418006295 DXD motif; other site 572418006296 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 572418006297 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 572418006298 active site 572418006299 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 572418006300 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 572418006301 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 572418006302 30S ribosomal protein S18; Provisional; Region: PRK13401 572418006303 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 572418006304 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 572418006305 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 572418006306 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 572418006307 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 572418006308 intersubunit interface [polypeptide binding]; other site 572418006309 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 572418006310 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 572418006311 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 572418006312 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 572418006313 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 572418006314 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 572418006315 precorrin-3B synthase; Region: CobG; TIGR02435 572418006316 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572418006318 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 572418006319 Precorrin-8X methylmutase; Region: CbiC; pfam02570 572418006320 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 572418006321 active site 572418006322 SAM binding site [chemical binding]; other site 572418006323 homodimer interface [polypeptide binding]; other site 572418006324 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 572418006325 active site 572418006326 SAM binding site [chemical binding]; other site 572418006327 homodimer interface [polypeptide binding]; other site 572418006328 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572418006329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418006330 S-adenosylmethionine binding site [chemical binding]; other site 572418006331 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 572418006332 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 572418006334 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 572418006335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418006336 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418006337 DNA binding residues [nucleotide binding] 572418006339 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 572418006340 active site 572418006341 SAM binding site [chemical binding]; other site 572418006342 homodimer interface [polypeptide binding]; other site 572418006347 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 572418006348 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 572418006351 putative transposase OrfB; Reviewed; Region: PHA02517 572418006352 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418006353 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418006354 active site 572418006355 ATP binding site [chemical binding]; other site 572418006356 substrate binding site [chemical binding]; other site 572418006357 activation loop (A-loop); other site 572418006358 PknH-like extracellular domain; Region: PknH_C; pfam14032 572418006360 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 572418006361 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 572418006362 active site 572418006364 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 572418006365 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 572418006366 active site 572418006367 metal binding site 1 [ion binding]; metal-binding site 572418006368 putative 5' ssDNA interaction site; other site 572418006369 metal binding site 3; metal-binding site 572418006370 metal binding site 2 [ion binding]; metal-binding site 572418006371 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 572418006372 putative DNA binding site [nucleotide binding]; other site 572418006373 putative metal binding site [ion binding]; other site 572418006374 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 572418006375 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 572418006376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418006377 ATP binding site [chemical binding]; other site 572418006378 putative Mg++ binding site [ion binding]; other site 572418006379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418006380 nucleotide binding region [chemical binding]; other site 572418006381 ATP-binding site [chemical binding]; other site 572418006382 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 572418006385 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 572418006386 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 572418006387 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 572418006389 Predicted transcriptional regulator [Transcription]; Region: COG2378 572418006390 WYL domain; Region: WYL; pfam13280 572418006391 Predicted transcriptional regulator [Transcription]; Region: COG2378 572418006392 WYL domain; Region: WYL; pfam13280 572418006393 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 572418006394 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418006395 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418006396 active site 572418006397 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 572418006398 SNF2 Helicase protein; Region: DUF3670; pfam12419 572418006399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418006400 ATP binding site [chemical binding]; other site 572418006401 putative Mg++ binding site [ion binding]; other site 572418006402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418006403 nucleotide binding region [chemical binding]; other site 572418006404 ATP-binding site [chemical binding]; other site 572418006405 Uncharacterized conserved protein [Function unknown]; Region: COG4279 572418006407 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 572418006408 putative active site [active] 572418006409 PE family; Region: PE; pfam00934 572418006410 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418006411 PPE family; Region: PPE; pfam00823 572418006412 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 572418006413 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 572418006414 active site 572418006415 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 572418006416 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 572418006417 active site 572418006418 Pup-like protein; Region: Pup; pfam05639 572418006419 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 572418006420 proteasome ATPase; Region: pup_AAA; TIGR03689 572418006421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418006422 Walker A motif; other site 572418006423 ATP binding site [chemical binding]; other site 572418006424 Walker B motif; other site 572418006425 arginine finger; other site 572418006428 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 572418006430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 572418006431 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 572418006432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418006433 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 572418006434 Predicted membrane protein [Function unknown]; Region: COG3918 572418006435 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 572418006436 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 572418006437 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 572418006438 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 572418006439 homodimer interface [polypeptide binding]; other site 572418006440 putative metal binding site [ion binding]; other site 572418006441 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418006442 PPE family; Region: PPE; pfam00823 572418006445 PAC2 family; Region: PAC2; pfam09754 572418006446 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 572418006448 short chain dehydrogenase; Provisional; Region: PRK05872 572418006449 classical (c) SDRs; Region: SDR_c; cd05233 572418006450 NAD(P) binding site [chemical binding]; other site 572418006451 active site 572418006452 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 572418006453 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 572418006454 active site 572418006455 HIGH motif; other site 572418006456 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572418006457 active site 572418006458 KMSKS motif; other site 572418006459 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 572418006460 putative tRNA binding surface [nucleotide binding]; other site 572418006461 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 572418006462 active site 572418006464 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418006465 conserved hypothetical protein; Region: TIGR03843 572418006466 conserved hypothetical protein; Region: TIGR03847 572418006467 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418006468 catalytic core [active] 572418006469 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 572418006471 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 572418006472 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 572418006473 quinone interaction residues [chemical binding]; other site 572418006474 active site 572418006475 catalytic residues [active] 572418006476 FMN binding site [chemical binding]; other site 572418006477 substrate binding site [chemical binding]; other site 572418006480 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 572418006481 substrate binding site [chemical binding]; other site 572418006482 hypothetical protein; Provisional; Region: PRK07906 572418006483 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 572418006484 putative metal binding site [ion binding]; other site 572418006486 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 572418006487 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418006488 active site 572418006489 DivIVA domain; Region: DivI1A_domain; TIGR03544 572418006490 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 572418006491 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 572418006492 Predicted integral membrane protein [Function unknown]; Region: COG0762 572418006493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 572418006494 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 572418006495 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572418006496 catalytic residue [active] 572418006497 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 572418006498 uncharacterized protein, YfiH family; Region: TIGR00726 572418006499 cell division protein FtsZ; Validated; Region: PRK09330 572418006500 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 572418006501 nucleotide binding site [chemical binding]; other site 572418006502 SulA interaction site; other site 572418006504 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 572418006505 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 572418006506 Cell division protein FtsQ; Region: FtsQ; pfam03799 572418006507 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 572418006508 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572418006509 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572418006510 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572418006511 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 572418006512 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 572418006513 active site 572418006514 homodimer interface [polypeptide binding]; other site 572418006515 cell division protein FtsW; Region: ftsW; TIGR02614 572418006516 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 572418006517 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572418006518 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572418006520 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 572418006521 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 572418006522 Mg++ binding site [ion binding]; other site 572418006523 putative catalytic motif [active] 572418006524 putative substrate binding site [chemical binding]; other site 572418006525 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 572418006526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572418006527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572418006528 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 572418006529 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 572418006530 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 572418006531 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572418006534 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 572418006535 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418006536 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418006537 PE family; Region: PE; pfam00934 572418006538 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572418006539 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 572418006540 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572418006542 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 572418006543 MraW methylase family; Region: Methyltransf_5; pfam01795 572418006544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 572418006545 MraZ protein; Region: MraZ; pfam02381 572418006546 MraZ protein; Region: MraZ; pfam02381 572418006547 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 572418006548 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 572418006551 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572418006552 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572418006553 substrate binding pocket [chemical binding]; other site 572418006554 chain length determination region; other site 572418006555 substrate-Mg2+ binding site; other site 572418006556 catalytic residues [active] 572418006557 aspartate-rich region 1; other site 572418006558 active site lid residues [active] 572418006559 aspartate-rich region 2; other site 572418006562 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 572418006563 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418006564 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418006565 active site 572418006566 ATP binding site [chemical binding]; other site 572418006567 substrate binding site [chemical binding]; other site 572418006568 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572418006569 substrate binding site [chemical binding]; other site 572418006570 activation loop (A-loop); other site 572418006571 activation loop (A-loop); other site 572418006573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 572418006574 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 572418006575 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 572418006576 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 572418006577 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418006578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572418006579 putative acyl-acceptor binding pocket; other site 572418006581 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 572418006582 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 572418006583 DTAP/Switch II; other site 572418006584 Switch I; other site 572418006585 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 572418006586 putative hydrophobic ligand binding site [chemical binding]; other site 572418006589 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572418006590 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572418006591 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 572418006592 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 572418006593 NlpC/P60 family; Region: NLPC_P60; pfam00877 572418006594 hypothetical protein; Validated; Region: PRK07883 572418006595 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 572418006596 active site 572418006597 catalytic site [active] 572418006598 substrate binding site [chemical binding]; other site 572418006599 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 572418006600 GIY-YIG motif/motif A; other site 572418006601 active site 572418006602 catalytic site [active] 572418006603 putative DNA binding site [nucleotide binding]; other site 572418006604 metal binding site [ion binding]; metal-binding site 572418006605 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 572418006606 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572418006607 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572418006608 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 572418006609 Subunit I/III interface [polypeptide binding]; other site 572418006610 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 572418006611 Cytochrome c; Region: Cytochrom_C; pfam00034 572418006612 Cytochrome c; Region: Cytochrom_C; cl11414 572418006613 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 572418006614 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 572418006615 iron-sulfur cluster [ion binding]; other site 572418006616 [2Fe-2S] cluster binding site [ion binding]; other site 572418006617 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 572418006618 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 572418006619 heme bH binding site [chemical binding]; other site 572418006620 intrachain domain interface; other site 572418006621 heme bL binding site [chemical binding]; other site 572418006622 interchain domain interface [polypeptide binding]; other site 572418006623 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 572418006624 Qo binding site; other site 572418006625 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 572418006626 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 572418006627 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 572418006628 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 572418006629 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 572418006630 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 572418006631 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 572418006632 dimer interface [polypeptide binding]; other site 572418006633 active site 572418006634 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 572418006635 Ligand Binding Site [chemical binding]; other site 572418006636 Molecular Tunnel; other site 572418006637 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 572418006638 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572418006639 substrate binding site [chemical binding]; other site 572418006640 ATP binding site [chemical binding]; other site 572418006641 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 572418006642 Glycerate kinase family; Region: Gly_kinase; pfam02595 572418006643 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 572418006644 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 572418006645 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 572418006646 putative dimer interface [polypeptide binding]; other site 572418006647 active site pocket [active] 572418006648 putative cataytic base [active] 572418006649 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 572418006651 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 572418006652 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 572418006653 homodimer interface [polypeptide binding]; other site 572418006654 substrate-cofactor binding pocket; other site 572418006655 catalytic residue [active] 572418006656 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 572418006657 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 572418006658 cyclase homology domain; Region: CHD; cd07302 572418006659 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418006660 nucleotidyl binding site; other site 572418006661 metal binding site [ion binding]; metal-binding site 572418006662 dimer interface [polypeptide binding]; other site 572418006663 multifunctional aminopeptidase A; Provisional; Region: PRK00913 572418006664 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 572418006665 interface (dimer of trimers) [polypeptide binding]; other site 572418006666 Substrate-binding/catalytic site; other site 572418006667 Zn-binding sites [ion binding]; other site 572418006668 short chain dehydrogenase; Validated; Region: PRK05855 572418006669 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572418006670 classical (c) SDRs; Region: SDR_c; cd05233 572418006671 NAD(P) binding site [chemical binding]; other site 572418006672 active site 572418006673 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 572418006674 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572418006675 E3 interaction surface; other site 572418006676 lipoyl attachment site [posttranslational modification]; other site 572418006677 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572418006678 E3 interaction surface; other site 572418006679 lipoyl attachment site [posttranslational modification]; other site 572418006680 e3 binding domain; Region: E3_binding; pfam02817 572418006681 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572418006682 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 572418006683 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 572418006684 putative NAD(P) binding site [chemical binding]; other site 572418006685 putative active site [active] 572418006686 lipoate-protein ligase B; Provisional; Region: PRK14345 572418006687 lipoyl synthase; Provisional; Region: PRK05481 572418006688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418006689 FeS/SAM binding site; other site 572418006690 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 572418006691 RDD family; Region: RDD; pfam06271 572418006692 glutamine synthetase, type I; Region: GlnA; TIGR00653 572418006693 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 572418006694 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 572418006697 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 572418006698 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 572418006699 metal binding triad; other site 572418006700 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 572418006701 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 572418006702 metal binding triad; other site 572418006703 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 572418006704 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 572418006705 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 572418006706 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 572418006707 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 572418006708 TAP-like protein; Region: Abhydrolase_4; pfam08386 572418006710 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 572418006711 TAP-like protein; Region: Abhydrolase_4; pfam08386 572418006713 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 572418006714 oligomerization interface [polypeptide binding]; other site 572418006715 active site 572418006716 metal binding site [ion binding]; metal-binding site 572418006717 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 572418006718 putative active site; other site 572418006719 putative metal binding residues [ion binding]; other site 572418006720 signature motif; other site 572418006721 putative triphosphate binding site [ion binding]; other site 572418006722 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 572418006724 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 572418006725 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 572418006726 RNA/DNA hybrid binding site [nucleotide binding]; other site 572418006727 active site 572418006728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418006729 catalytic core [active] 572418006730 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 572418006731 Putative zinc ribbon domain; Region: DUF164; pfam02591 572418006732 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 572418006733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 572418006734 Uncharacterized conserved protein [Function unknown]; Region: COG0327 572418006735 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 572418006736 hypothetical protein; Provisional; Region: PRK07908 572418006737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418006738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418006739 homodimer interface [polypeptide binding]; other site 572418006740 catalytic residue [active] 572418006742 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572418006743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418006744 active site 572418006745 motif I; other site 572418006746 motif II; other site 572418006747 Low molecular weight phosphatase family; Region: LMWPc; cd00115 572418006748 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 572418006749 active site 572418006750 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 572418006751 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 572418006752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 572418006753 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 572418006754 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 572418006755 dimer interface [polypeptide binding]; other site 572418006756 catalytic triad [active] 572418006757 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 572418006758 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 572418006759 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 572418006760 dimer interface [polypeptide binding]; other site 572418006761 TPP-binding site [chemical binding]; other site 572418006762 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 572418006763 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 572418006764 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 572418006765 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572418006766 acyl carrier protein; Provisional; Region: acpP; PRK00982 572418006767 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 572418006768 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 572418006769 dimer interface [polypeptide binding]; other site 572418006770 active site 572418006771 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 572418006772 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 572418006773 dimer interface [polypeptide binding]; other site 572418006774 active site 572418006775 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 572418006776 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 572418006777 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572418006778 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 572418006779 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 572418006780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418006781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418006782 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418006783 FAD binding domain; Region: FAD_binding_4; pfam01565 572418006784 diacylglycerol kinase; Reviewed; Region: PRK11914 572418006785 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 572418006786 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 572418006787 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418006788 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418006789 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572418006790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418006791 S-adenosylmethionine binding site [chemical binding]; other site 572418006792 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 572418006793 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 572418006794 NAD binding site [chemical binding]; other site 572418006795 catalytic Zn binding site [ion binding]; other site 572418006796 substrate binding site [chemical binding]; other site 572418006797 structural Zn binding site [ion binding]; other site 572418006799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572418006800 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 572418006801 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 572418006802 putative active site [active] 572418006803 catalytic triad [active] 572418006804 putative dimer interface [polypeptide binding]; other site 572418006805 short chain dehydrogenase; Provisional; Region: PRK05854 572418006806 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 572418006807 putative NAD(P) binding site [chemical binding]; other site 572418006808 active site 572418006809 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 572418006810 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572418006811 nucleotide binding site [chemical binding]; other site 572418006812 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572418006813 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418006814 Cytochrome P450; Region: p450; cl12078 572418006815 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 572418006816 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418006817 Cytochrome P450; Region: p450; cl12078 572418006819 Septum formation; Region: Septum_form; pfam13845 572418006820 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 572418006821 Predicted membrane protein [Function unknown]; Region: COG2149 572418006822 Domain of unknown function (DUF202); Region: DUF202; pfam02656 572418006825 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 572418006826 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 572418006827 putative active site [active] 572418006828 catalytic site [active] 572418006829 putative metal binding site [ion binding]; other site 572418006830 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 572418006831 FAD binding domain; Region: FAD_binding_4; pfam01565 572418006832 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 572418006833 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 572418006834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 572418006835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 572418006836 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 572418006837 dimerization interface [polypeptide binding]; other site 572418006839 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418006840 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418006841 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572418006842 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418006843 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418006844 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 572418006845 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 572418006846 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 572418006847 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 572418006848 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 572418006849 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 572418006850 active site residue [active] 572418006851 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 572418006852 active site residue [active] 572418006853 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 572418006854 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 572418006855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418006856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418006857 homodimer interface [polypeptide binding]; other site 572418006858 catalytic residue [active] 572418006859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 572418006860 haloalkane dehalogenase; Provisional; Region: PRK00870 572418006861 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572418006862 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572418006863 active site 572418006864 catalytic tetrad [active] 572418006866 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572418006867 Cutinase; Region: Cutinase; pfam01083 572418006869 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 572418006870 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 572418006871 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 572418006872 Uncharacterized conserved protein [Function unknown]; Region: COG0398 572418006873 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 572418006874 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 572418006875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 572418006876 Uncharacterized conserved protein [Function unknown]; Region: COG2442 572418006877 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572418006878 DNA binding site [nucleotide binding] 572418006879 active site 572418006880 Int/Topo IB signature motif; other site 572418006881 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 572418006882 DNA binding residues [nucleotide binding] 572418006883 Family description; Region: UvrD_C_2; pfam13538 572418006884 Uncharacterized conserved protein [Function unknown]; Region: COG2128 572418006885 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 572418006886 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 572418006887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418006888 putative PBP binding loops; other site 572418006889 ABC-ATPase subunit interface; other site 572418006890 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 572418006891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418006892 dimer interface [polypeptide binding]; other site 572418006893 conserved gate region; other site 572418006894 putative PBP binding loops; other site 572418006895 ABC-ATPase subunit interface; other site 572418006896 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 572418006897 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 572418006898 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418006899 Ligand Binding Site [chemical binding]; other site 572418006900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418006901 Ligand Binding Site [chemical binding]; other site 572418006902 amino acid transporter; Region: 2A0306; TIGR00909 572418006903 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 572418006904 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 572418006905 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572418006906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418006907 catalytic residue [active] 572418006909 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572418006910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418006911 Amidinotransferase; Region: Amidinotransf; pfam02274 572418006912 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 572418006913 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 572418006914 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 572418006915 putative DNA binding site [nucleotide binding]; other site 572418006916 putative Zn2+ binding site [ion binding]; other site 572418006917 AsnC family; Region: AsnC_trans_reg; pfam01037 572418006918 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 572418006919 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572418006920 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 572418006921 Walker A/P-loop; other site 572418006922 ATP binding site [chemical binding]; other site 572418006923 Q-loop/lid; other site 572418006924 ABC transporter signature motif; other site 572418006925 Walker B; other site 572418006926 D-loop; other site 572418006927 H-loop/switch region; other site 572418006928 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 572418006929 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 572418006930 Walker A/P-loop; other site 572418006931 ATP binding site [chemical binding]; other site 572418006932 Q-loop/lid; other site 572418006933 ABC transporter signature motif; other site 572418006934 Walker B; other site 572418006935 D-loop; other site 572418006936 H-loop/switch region; other site 572418006941 MarR family; Region: MarR; pfam01047 572418006942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572418006943 PE family; Region: PE; pfam00934 572418006944 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 572418006945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418006946 putative substrate translocation pore; other site 572418006947 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 572418006948 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 572418006949 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 572418006950 malate dehydrogenase; Provisional; Region: PRK13529 572418006951 Malic enzyme, N-terminal domain; Region: malic; pfam00390 572418006952 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 572418006953 NAD(P) binding site [chemical binding]; other site 572418006955 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 572418006956 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 572418006957 dimer interface [polypeptide binding]; other site 572418006958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418006959 catalytic residue [active] 572418006961 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 572418006962 serine O-acetyltransferase; Region: cysE; TIGR01172 572418006963 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 572418006964 trimer interface [polypeptide binding]; other site 572418006965 active site 572418006966 substrate binding site [chemical binding]; other site 572418006967 CoA binding site [chemical binding]; other site 572418006969 hypothetical protein; Provisional; Region: PRK14851 572418006970 hypothetical protein; Validated; Region: PRK08223 572418006971 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 572418006972 ATP binding site [chemical binding]; other site 572418006973 substrate interface [chemical binding]; other site 572418006974 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418006975 PE family; Region: PE; pfam00934 572418006977 DNA primase; Validated; Region: dnaG; PRK05667 572418006978 CHC2 zinc finger; Region: zf-CHC2; pfam01807 572418006979 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 572418006980 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 572418006981 active site 572418006982 metal binding site [ion binding]; metal-binding site 572418006983 interdomain interaction site; other site 572418006984 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 572418006985 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 572418006986 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 572418006987 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572418006988 Zn2+ binding site [ion binding]; other site 572418006989 Mg2+ binding site [ion binding]; other site 572418006990 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 572418006991 Repair protein; Region: Repair_PSII; pfam04536 572418006992 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 572418006993 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572418006994 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 572418006995 Phosphoesterase family; Region: Phosphoesterase; pfam04185 572418006996 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 572418006997 Phosphoesterase family; Region: Phosphoesterase; pfam04185 572418006998 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 572418006999 Phosphoesterase family; Region: Phosphoesterase; pfam04185 572418007000 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418007001 PPE family; Region: PPE; pfam00823 572418007002 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 572418007003 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 572418007004 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418007005 PPE family; Region: PPE; pfam00823 572418007006 PPE family; Region: PPE; pfam00823 572418007007 PPE family; Region: PPE; pfam00823 572418007008 PPE family; Region: PPE; pfam00823 572418007009 glycyl-tRNA synthetase; Provisional; Region: PRK04173 572418007010 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572418007011 motif 1; other site 572418007012 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 572418007013 active site 572418007014 motif 2; other site 572418007015 motif 3; other site 572418007016 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 572418007017 anticodon binding site; other site 572418007020 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418007021 dimerization interface [polypeptide binding]; other site 572418007022 putative DNA binding site [nucleotide binding]; other site 572418007023 putative Zn2+ binding site [ion binding]; other site 572418007024 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 572418007025 metal binding site 2 [ion binding]; metal-binding site 572418007026 putative DNA binding helix; other site 572418007027 metal binding site 1 [ion binding]; metal-binding site 572418007028 dimer interface [polypeptide binding]; other site 572418007029 structural Zn2+ binding site [ion binding]; other site 572418007030 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 572418007031 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 572418007032 catalytic residue [active] 572418007033 putative FPP diphosphate binding site; other site 572418007034 putative FPP binding hydrophobic cleft; other site 572418007035 dimer interface [polypeptide binding]; other site 572418007036 putative IPP diphosphate binding site; other site 572418007038 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 572418007039 Recombination protein O N terminal; Region: RecO_N; pfam11967 572418007040 Recombination protein O C terminal; Region: RecO_C; pfam02565 572418007041 amidase; Provisional; Region: PRK06061 572418007042 Amidase; Region: Amidase; pfam01425 572418007045 GTPase Era; Reviewed; Region: era; PRK00089 572418007046 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 572418007047 G1 box; other site 572418007048 GTP/Mg2+ binding site [chemical binding]; other site 572418007049 Switch I region; other site 572418007050 G2 box; other site 572418007051 Switch II region; other site 572418007052 G3 box; other site 572418007053 G4 box; other site 572418007054 G5 box; other site 572418007055 KH domain; Region: KH_2; pfam07650 572418007057 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 572418007058 Domain of unknown function DUF21; Region: DUF21; pfam01595 572418007059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572418007060 Transporter associated domain; Region: CorC_HlyC; smart01091 572418007061 metal-binding heat shock protein; Provisional; Region: PRK00016 572418007062 K homology RNA-binding domain; Region: KH; smart00322 572418007063 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 572418007064 PhoH-like protein; Region: PhoH; pfam02562 572418007066 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 572418007067 PE family; Region: PE; pfam00934 572418007068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 572418007069 RNA methyltransferase, RsmE family; Region: TIGR00046 572418007070 chaperone protein DnaJ; Provisional; Region: PRK14278 572418007071 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 572418007072 HSP70 interaction site [polypeptide binding]; other site 572418007073 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 572418007074 Zn binding sites [ion binding]; other site 572418007075 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 572418007076 dimer interface [polypeptide binding]; other site 572418007077 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 572418007078 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 572418007079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 572418007080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418007081 Condensation domain; Region: Condensation; pfam00668 572418007082 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 572418007083 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 572418007084 acyl-activating enzyme (AAE) consensus motif; other site 572418007085 AMP binding site [chemical binding]; other site 572418007086 Condensation domain; Region: Condensation; pfam00668 572418007087 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 572418007089 Condensation domain; Region: Condensation; pfam00668 572418007090 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 572418007091 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 572418007092 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 572418007093 acyl-activating enzyme (AAE) consensus motif; other site 572418007094 AMP binding site [chemical binding]; other site 572418007095 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572418007096 Condensation domain; Region: Condensation; pfam00668 572418007097 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 572418007098 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 572418007099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418007100 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572418007103 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572418007104 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418007105 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 572418007106 NADP binding site [chemical binding]; other site 572418007107 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 572418007108 active site 572418007109 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418007111 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418007112 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 572418007113 active site 572418007114 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 572418007115 Condensation domain; Region: Condensation; pfam00668 572418007116 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 572418007117 Nonribosomal peptide synthase; Region: NRPS; pfam08415 572418007118 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 572418007119 acyl-activating enzyme (AAE) consensus motif; other site 572418007120 AMP binding site [chemical binding]; other site 572418007121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572418007122 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 572418007125 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 572418007126 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 572418007127 acyl-activating enzyme (AAE) consensus motif; other site 572418007128 active site 572418007129 AMP binding site [chemical binding]; other site 572418007130 substrate binding site [chemical binding]; other site 572418007132 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 572418007133 salicylate synthase MbtI; Reviewed; Region: PRK07912 572418007134 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 572418007135 Predicted permease [General function prediction only]; Region: COG3329 572418007137 coproporphyrinogen III oxidase; Validated; Region: PRK05628 572418007138 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 572418007139 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 572418007140 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572418007141 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 572418007142 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 572418007143 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 572418007144 Active Sites [active] 572418007145 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 572418007146 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 572418007147 putative active site [active] 572418007148 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 572418007149 putative active site [active] 572418007150 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 572418007151 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 572418007152 Predicted membrane protein [Function unknown]; Region: COG1297 572418007153 putative oligopeptide transporter, OPT family; Region: TIGR00733 572418007154 PE family; Region: PE; pfam00934 572418007156 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 572418007157 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 572418007158 Walker A/P-loop; other site 572418007159 ATP binding site [chemical binding]; other site 572418007160 Q-loop/lid; other site 572418007161 ABC transporter signature motif; other site 572418007162 Walker B; other site 572418007163 D-loop; other site 572418007164 H-loop/switch region; other site 572418007167 sulfate transport protein; Provisional; Region: cysT; CHL00187 572418007168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418007169 dimer interface [polypeptide binding]; other site 572418007170 conserved gate region; other site 572418007171 putative PBP binding loops; other site 572418007172 ABC-ATPase subunit interface; other site 572418007174 sulfate transport protein; Provisional; Region: cysT; CHL00187 572418007175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418007176 dimer interface [polypeptide binding]; other site 572418007177 conserved gate region; other site 572418007178 putative PBP binding loops; other site 572418007179 ABC-ATPase subunit interface; other site 572418007182 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 572418007183 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 572418007184 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 572418007185 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 572418007186 PknH-like extracellular domain; Region: PknH_C; pfam14032 572418007187 GTP-binding protein LepA; Provisional; Region: PRK05433 572418007188 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 572418007189 G1 box; other site 572418007190 putative GEF interaction site [polypeptide binding]; other site 572418007191 GTP/Mg2+ binding site [chemical binding]; other site 572418007192 Switch I region; other site 572418007193 G2 box; other site 572418007194 G3 box; other site 572418007195 Switch II region; other site 572418007196 G4 box; other site 572418007197 G5 box; other site 572418007198 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 572418007199 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 572418007200 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 572418007203 PemK-like protein; Region: PemK; pfam02452 572418007204 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 572418007205 FOG: CBS domain [General function prediction only]; Region: COG0517 572418007206 ribonuclease Z; Reviewed; Region: PRK00055 572418007207 PE family; Region: PE; pfam00934 572418007208 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572418007209 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 572418007210 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572418007211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 572418007212 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 572418007213 Uncharacterized conserved protein [Function unknown]; Region: COG2308 572418007214 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 572418007215 hypothetical protein; Reviewed; Region: PRK07914 572418007216 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 572418007217 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 572418007218 Competence protein; Region: Competence; pfam03772 572418007219 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 572418007220 Helix-hairpin-helix motif; Region: HHH; pfam00633 572418007221 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 572418007222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418007223 Coenzyme A binding pocket [chemical binding]; other site 572418007224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 572418007225 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 572418007226 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 572418007227 active site 572418007228 catalytic triad [active] 572418007229 oxyanion hole [active] 572418007230 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418007231 catalytic core [active] 572418007233 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 572418007234 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 572418007235 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 572418007236 active site 572418007237 (T/H)XGH motif; other site 572418007238 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572418007239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418007240 S-adenosylmethionine binding site [chemical binding]; other site 572418007241 Transposase; Region: DEDD_Tnp_IS110; pfam01548 572418007242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 572418007243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 572418007245 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 572418007246 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 572418007247 metal ion-dependent adhesion site (MIDAS); other site 572418007248 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572418007249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418007250 Walker A motif; other site 572418007251 ATP binding site [chemical binding]; other site 572418007252 Walker B motif; other site 572418007253 arginine finger; other site 572418007255 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 572418007256 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 572418007257 putative catalytic cysteine [active] 572418007259 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 572418007260 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 572418007261 dimer interface [polypeptide binding]; other site 572418007262 decamer (pentamer of dimers) interface [polypeptide binding]; other site 572418007263 catalytic triad [active] 572418007264 peroxidatic and resolving cysteines [active] 572418007265 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 572418007266 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 572418007267 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418007268 PPE family; Region: PPE; pfam00823 572418007269 PE family; Region: PE; pfam00934 572418007270 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 572418007271 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572418007272 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418007273 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418007274 ligand binding site [chemical binding]; other site 572418007275 flexible hinge region; other site 572418007276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418007277 dimerization interface [polypeptide binding]; other site 572418007278 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 572418007279 cyclase homology domain; Region: CHD; cd07302 572418007280 nucleotidyl binding site; other site 572418007281 metal binding site [ion binding]; metal-binding site 572418007282 dimer interface [polypeptide binding]; other site 572418007283 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 572418007284 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 572418007285 substrate binding site [chemical binding]; other site 572418007286 dimer interface [polypeptide binding]; other site 572418007287 ATP binding site [chemical binding]; other site 572418007289 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 572418007290 NAD synthetase; Reviewed; Region: nadE; PRK02628 572418007291 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 572418007292 multimer interface [polypeptide binding]; other site 572418007293 active site 572418007294 catalytic triad [active] 572418007295 protein interface 1 [polypeptide binding]; other site 572418007296 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 572418007297 homodimer interface [polypeptide binding]; other site 572418007298 NAD binding pocket [chemical binding]; other site 572418007299 ATP binding pocket [chemical binding]; other site 572418007300 Mg binding site [ion binding]; other site 572418007301 active-site loop [active] 572418007303 gamma-glutamyl kinase; Provisional; Region: PRK05429 572418007304 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 572418007305 nucleotide binding site [chemical binding]; other site 572418007306 homotetrameric interface [polypeptide binding]; other site 572418007307 putative phosphate binding site [ion binding]; other site 572418007308 putative allosteric binding site; other site 572418007309 PUA domain; Region: PUA; pfam01472 572418007311 GTPase CgtA; Reviewed; Region: obgE; PRK12296 572418007312 GTP1/OBG; Region: GTP1_OBG; pfam01018 572418007313 Obg GTPase; Region: Obg; cd01898 572418007314 G1 box; other site 572418007315 GTP/Mg2+ binding site [chemical binding]; other site 572418007316 Switch I region; other site 572418007317 G2 box; other site 572418007318 G3 box; other site 572418007319 Switch II region; other site 572418007320 G4 box; other site 572418007321 G5 box; other site 572418007322 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 572418007324 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 572418007326 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 572418007327 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 572418007328 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 572418007329 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 572418007330 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 572418007331 homodimer interface [polypeptide binding]; other site 572418007332 oligonucleotide binding site [chemical binding]; other site 572418007333 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 572418007334 active site 572418007335 multimer interface [polypeptide binding]; other site 572418007336 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 572418007337 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 572418007338 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 572418007340 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 572418007341 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572418007342 active site 572418007343 HIGH motif; other site 572418007344 nucleotide binding site [chemical binding]; other site 572418007345 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 572418007346 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 572418007347 active site 572418007348 KMSKS motif; other site 572418007349 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 572418007350 tRNA binding surface [nucleotide binding]; other site 572418007351 anticodon binding site; other site 572418007352 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 572418007354 Uncharacterized conserved protein [Function unknown]; Region: COG3268 572418007355 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 572418007356 NAD(P) binding pocket [chemical binding]; other site 572418007357 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 572418007358 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 572418007359 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 572418007360 GTP binding site; other site 572418007361 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 572418007362 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 572418007363 TPP-binding site [chemical binding]; other site 572418007364 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 572418007365 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 572418007366 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 572418007367 dimer interface [polypeptide binding]; other site 572418007368 PYR/PP interface [polypeptide binding]; other site 572418007369 TPP binding site [chemical binding]; other site 572418007370 substrate binding site [chemical binding]; other site 572418007372 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 572418007373 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 572418007374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418007375 Walker A motif; other site 572418007376 ATP binding site [chemical binding]; other site 572418007377 Walker B motif; other site 572418007378 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 572418007380 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 572418007381 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 572418007382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418007383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572418007384 putative substrate translocation pore; other site 572418007385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418007386 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 572418007387 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 572418007388 oligomer interface [polypeptide binding]; other site 572418007389 active site residues [active] 572418007391 Clp protease; Region: CLP_protease; pfam00574 572418007392 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 572418007393 oligomer interface [polypeptide binding]; other site 572418007394 active site residues [active] 572418007395 trigger factor; Provisional; Region: tig; PRK01490 572418007396 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 572418007397 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 572418007398 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418007399 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418007400 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 572418007401 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 572418007402 putative DNA binding site [nucleotide binding]; other site 572418007403 catalytic residue [active] 572418007404 putative H2TH interface [polypeptide binding]; other site 572418007405 putative catalytic residues [active] 572418007406 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 572418007407 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572418007408 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 572418007409 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 572418007410 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 572418007412 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 572418007413 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 572418007414 Zn binding site [ion binding]; other site 572418007416 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 572418007417 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418007418 active site 572418007419 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 572418007420 apolar tunnel; other site 572418007421 heme binding site [chemical binding]; other site 572418007422 dimerization interface [polypeptide binding]; other site 572418007423 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 572418007424 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 572418007425 active site 572418007426 catalytic site [active] 572418007427 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 572418007428 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 572418007429 active site 572418007430 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 572418007431 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 572418007432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572418007433 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572418007434 ABC transporter; Region: ABC_tran_2; pfam12848 572418007435 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 572418007440 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572418007441 dimer interface [polypeptide binding]; other site 572418007442 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 572418007443 ssDNA binding site [nucleotide binding]; other site 572418007444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 572418007445 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 572418007446 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 572418007447 putative acyl-acceptor binding pocket; other site 572418007448 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 572418007449 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 572418007450 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418007451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572418007452 putative acyl-acceptor binding pocket; other site 572418007453 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418007454 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418007455 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 572418007456 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418007457 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572418007458 enoyl-CoA hydratase; Provisional; Region: PRK05870 572418007459 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418007460 substrate binding site [chemical binding]; other site 572418007461 oxyanion hole (OAH) forming residues; other site 572418007462 trimer interface [polypeptide binding]; other site 572418007464 PE family; Region: PE; pfam00934 572418007465 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418007466 cyclase homology domain; Region: CHD; cd07302 572418007467 nucleotidyl binding site; other site 572418007468 metal binding site [ion binding]; metal-binding site 572418007469 dimer interface [polypeptide binding]; other site 572418007470 Predicted ATPase [General function prediction only]; Region: COG3903 572418007471 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572418007472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572418007473 DNA binding residues [nucleotide binding] 572418007474 dimerization interface [polypeptide binding]; other site 572418007477 PE family; Region: PE; pfam00934 572418007478 TIGR00725 family protein; Region: TIGR00725 572418007479 thymidylate synthase; Provisional; Region: thyA; PRK00956 572418007480 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418007481 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 572418007482 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572418007483 E3 interaction surface; other site 572418007484 lipoyl attachment site [posttranslational modification]; other site 572418007485 e3 binding domain; Region: E3_binding; pfam02817 572418007486 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 572418007487 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 572418007488 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 572418007489 alpha subunit interface [polypeptide binding]; other site 572418007490 TPP binding site [chemical binding]; other site 572418007491 heterodimer interface [polypeptide binding]; other site 572418007492 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572418007493 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 572418007494 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 572418007495 tetramer interface [polypeptide binding]; other site 572418007496 TPP-binding site [chemical binding]; other site 572418007497 heterodimer interface [polypeptide binding]; other site 572418007498 phosphorylation loop region [posttranslational modification] 572418007499 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 572418007500 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 572418007501 putative active site [active] 572418007502 putative catalytic site [active] 572418007503 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418007504 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418007505 active site 572418007508 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 572418007509 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572418007510 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 572418007511 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572418007512 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572418007513 carboxyltransferase (CT) interaction site; other site 572418007514 biotinylation site [posttranslational modification]; other site 572418007518 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 572418007519 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 572418007520 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572418007521 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 572418007522 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 572418007523 AMP-binding domain protein; Validated; Region: PRK08315 572418007524 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418007525 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 572418007526 acyl-activating enzyme (AAE) consensus motif; other site 572418007527 acyl-activating enzyme (AAE) consensus motif; other site 572418007528 putative AMP binding site [chemical binding]; other site 572418007529 putative active site [active] 572418007530 putative CoA binding site [chemical binding]; other site 572418007531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418007532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418007533 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 572418007534 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 572418007535 classical (c) SDRs; Region: SDR_c; cd05233 572418007536 NAD(P) binding site [chemical binding]; other site 572418007537 active site 572418007539 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 572418007541 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 572418007542 catalytic site [active] 572418007543 putative active site [active] 572418007544 putative substrate binding site [chemical binding]; other site 572418007545 dimer interface [polypeptide binding]; other site 572418007546 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418007547 MULE transposase domain; Region: MULE; pfam10551 572418007548 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 572418007549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418007550 non-specific DNA binding site [nucleotide binding]; other site 572418007551 salt bridge; other site 572418007552 sequence-specific DNA binding site [nucleotide binding]; other site 572418007553 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 572418007555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 572418007556 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 572418007557 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 572418007558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 572418007559 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 572418007561 PE family; Region: PE; pfam00934 572418007562 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 572418007563 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 572418007564 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572418007565 catalytic triad [active] 572418007566 hypothetical protein; Provisional; Region: PRK07907 572418007567 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 572418007568 active site 572418007569 metal binding site [ion binding]; metal-binding site 572418007570 dimer interface [polypeptide binding]; other site 572418007571 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 572418007572 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 572418007573 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 572418007574 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572418007575 phosphate binding site [ion binding]; other site 572418007576 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 572418007577 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 572418007578 putative active site [active] 572418007579 putative catalytic site [active] 572418007580 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 572418007581 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572418007582 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 572418007583 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 572418007584 putative NAD(P) binding site [chemical binding]; other site 572418007585 active site 572418007586 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 572418007587 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 572418007588 active site 572418007591 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 572418007592 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 572418007593 putative active site [active] 572418007594 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 572418007595 Mrr N-terminal domain; Region: Mrr_N; pfam14338 572418007596 Restriction endonuclease; Region: Mrr_cat; pfam04471 572418007597 ERCC4 domain; Region: ERCC4; pfam02732 572418007598 Lsr2; Region: Lsr2; pfam11774 572418007599 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 572418007600 putative active site [active] 572418007601 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418007602 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 572418007603 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572418007604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418007605 catalytic residue [active] 572418007606 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 572418007607 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 572418007608 putative RNA binding site [nucleotide binding]; other site 572418007609 elongation factor P; Validated; Region: PRK00529 572418007610 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 572418007611 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 572418007612 RNA binding site [nucleotide binding]; other site 572418007613 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 572418007614 RNA binding site [nucleotide binding]; other site 572418007615 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 572418007616 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 572418007617 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 572418007618 active site 572418007619 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 572418007620 Dehydroquinase class II; Region: DHquinase_II; pfam01220 572418007621 trimer interface [polypeptide binding]; other site 572418007622 active site 572418007623 dimer interface [polypeptide binding]; other site 572418007625 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 572418007626 active site 572418007627 dimer interface [polypeptide binding]; other site 572418007628 metal binding site [ion binding]; metal-binding site 572418007629 shikimate kinase; Reviewed; Region: aroK; PRK00131 572418007630 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 572418007631 ADP binding site [chemical binding]; other site 572418007632 magnesium binding site [ion binding]; other site 572418007633 putative shikimate binding site; other site 572418007636 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 572418007637 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 572418007638 Tetramer interface [polypeptide binding]; other site 572418007639 active site 572418007640 FMN-binding site [chemical binding]; other site 572418007642 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 572418007644 digalactosyldiacylglycerol synthase; Region: PLN02846 572418007645 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 572418007646 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 572418007647 putative active site [active] 572418007648 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418007649 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 572418007650 oligomeric interface; other site 572418007651 putative active site [active] 572418007652 homodimer interface [polypeptide binding]; other site 572418007653 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 572418007654 putative active site [active] 572418007655 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418007656 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 572418007657 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 572418007658 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 572418007659 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 572418007660 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 572418007661 NAD(P) binding site [chemical binding]; other site 572418007662 shikimate binding site; other site 572418007663 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 572418007664 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 572418007665 dimerization interface [polypeptide binding]; other site 572418007666 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 572418007667 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 572418007668 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 572418007669 motif 1; other site 572418007670 active site 572418007671 motif 2; other site 572418007672 motif 3; other site 572418007673 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 572418007674 DHHA1 domain; Region: DHHA1; pfam02272 572418007675 Uncharacterized conserved protein [Function unknown]; Region: COG0432 572418007676 recombination factor protein RarA; Reviewed; Region: PRK13342 572418007677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418007678 Walker A motif; other site 572418007679 ATP binding site [chemical binding]; other site 572418007680 Walker B motif; other site 572418007681 arginine finger; other site 572418007682 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 572418007684 Predicted integral membrane protein [Function unknown]; Region: COG5473 572418007685 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 572418007686 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 572418007687 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 572418007688 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 572418007689 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572418007690 Walker A/P-loop; other site 572418007691 ATP binding site [chemical binding]; other site 572418007692 Q-loop/lid; other site 572418007693 ABC transporter signature motif; other site 572418007694 Walker B; other site 572418007695 D-loop; other site 572418007696 H-loop/switch region; other site 572418007697 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418007698 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418007699 ligand binding site [chemical binding]; other site 572418007700 flexible hinge region; other site 572418007704 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418007705 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418007706 ligand binding site [chemical binding]; other site 572418007707 flexible hinge region; other site 572418007708 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572418007709 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 572418007710 active site 572418007711 nucleophile elbow; other site 572418007712 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572418007713 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 572418007714 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 572418007715 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 572418007716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 572418007717 Uncharacterized conserved protein [Function unknown]; Region: COG2308 572418007718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 572418007719 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 572418007720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 572418007721 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 572418007722 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 572418007723 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 572418007724 Transglutaminase/protease-like homologues; Region: TGc; smart00460 572418007725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 572418007726 Predicted membrane protein [Function unknown]; Region: COG4129 572418007727 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 572418007728 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 572418007729 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 572418007730 dimer interface [polypeptide binding]; other site 572418007731 anticodon binding site; other site 572418007732 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 572418007733 homodimer interface [polypeptide binding]; other site 572418007734 motif 1; other site 572418007735 active site 572418007736 motif 2; other site 572418007737 GAD domain; Region: GAD; pfam02938 572418007738 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572418007739 active site 572418007740 motif 3; other site 572418007742 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 572418007743 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 572418007744 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 572418007745 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 572418007746 putative hydrophobic ligand binding site [chemical binding]; other site 572418007747 protein interface [polypeptide binding]; other site 572418007748 gate; other site 572418007749 Predicted metalloprotease [General function prediction only]; Region: COG2321 572418007750 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 572418007752 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 572418007753 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 572418007754 active site 572418007755 metal binding site [ion binding]; metal-binding site 572418007756 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 572418007757 haloalkane dehalogenase; Provisional; Region: PRK03592 572418007758 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 572418007759 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 572418007760 dimer interface [polypeptide binding]; other site 572418007761 motif 1; other site 572418007762 active site 572418007763 motif 2; other site 572418007764 motif 3; other site 572418007765 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 572418007766 anticodon binding site; other site 572418007768 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 572418007769 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 572418007770 active site 572418007771 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 572418007772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572418007773 Zn2+ binding site [ion binding]; other site 572418007774 Mg2+ binding site [ion binding]; other site 572418007775 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 572418007776 synthetase active site [active] 572418007777 NTP binding site [chemical binding]; other site 572418007778 metal binding site [ion binding]; metal-binding site 572418007779 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 572418007780 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 572418007781 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418007782 active site 572418007785 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 572418007786 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 572418007787 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 572418007788 Protein export membrane protein; Region: SecD_SecF; pfam02355 572418007789 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 572418007790 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 572418007791 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 572418007792 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 572418007793 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572418007794 inhibitor-cofactor binding pocket; inhibition site 572418007795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418007796 catalytic residue [active] 572418007798 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 572418007799 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418007800 acyl-activating enzyme (AAE) consensus motif; other site 572418007801 AMP binding site [chemical binding]; other site 572418007802 active site 572418007803 CoA binding site [chemical binding]; other site 572418007804 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 572418007805 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 572418007806 putative NAD(P) binding site [chemical binding]; other site 572418007807 active site 572418007808 putative substrate binding site [chemical binding]; other site 572418007811 PE family; Region: PE; pfam00934 572418007813 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 572418007814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418007815 Walker A motif; other site 572418007816 ATP binding site [chemical binding]; other site 572418007817 Walker B motif; other site 572418007818 arginine finger; other site 572418007819 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 572418007821 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 572418007822 RuvA N terminal domain; Region: RuvA_N; pfam01330 572418007823 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 572418007824 active site 572418007825 putative DNA-binding cleft [nucleotide binding]; other site 572418007826 dimer interface [polypeptide binding]; other site 572418007827 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 572418007828 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 572418007829 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 572418007830 putative active site [active] 572418007831 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 572418007832 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 572418007833 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 572418007835 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 572418007836 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 572418007837 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 572418007838 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 572418007839 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418007840 hypothetical protein; Validated; Region: PRK00110 572418007841 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 572418007842 predicted active site [active] 572418007843 catalytic triad [active] 572418007844 acyl-CoA thioesterase II; Region: tesB; TIGR00189 572418007845 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 572418007846 active site 572418007847 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 572418007848 catalytic triad [active] 572418007849 dimer interface [polypeptide binding]; other site 572418007850 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 572418007851 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 572418007852 active site 572418007853 multimer interface [polypeptide binding]; other site 572418007855 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418007856 PPE family; Region: PPE; pfam00823 572418007857 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418007858 PE-PPE domain; Region: PE-PPE; pfam08237 572418007859 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 572418007860 nudix motif; other site 572418007862 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572418007863 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572418007865 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 572418007866 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 572418007867 putative acyl-acceptor binding pocket; other site 572418007868 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 572418007870 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 572418007871 nucleotide binding site/active site [active] 572418007872 HIT family signature motif; other site 572418007873 catalytic residue [active] 572418007874 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 572418007875 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 572418007876 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 572418007877 active site 572418007878 dimer interface [polypeptide binding]; other site 572418007879 motif 1; other site 572418007880 motif 2; other site 572418007881 motif 3; other site 572418007882 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 572418007883 anticodon binding site; other site 572418007885 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572418007886 phosphate binding site [ion binding]; other site 572418007887 PE family; Region: PE; pfam00934 572418007888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 572418007889 Predicted transcriptional regulator [Transcription]; Region: COG2345 572418007890 Helix-turn-helix domain; Region: HTH_20; pfam12840 572418007891 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 572418007893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418007894 S-adenosylmethionine binding site [chemical binding]; other site 572418007895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572418007897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418007898 Ligand Binding Site [chemical binding]; other site 572418007899 Universal stress protein family; Region: Usp; pfam00582 572418007900 Ligand Binding Site [chemical binding]; other site 572418007901 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 572418007902 active site 572418007903 Peptidase family M50; Region: Peptidase_M50; pfam02163 572418007904 putative substrate binding region [chemical binding]; other site 572418007905 FOG: CBS domain [General function prediction only]; Region: COG0517 572418007906 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 572418007908 FOG: CBS domain [General function prediction only]; Region: COG0517 572418007909 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 572418007910 peptide chain release factor 1; Provisional; Region: PRK04011 572418007911 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 572418007912 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 572418007913 hypothetical protein; Reviewed; Region: PRK09588 572418007914 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 572418007915 Hemerythrin-like domain; Region: Hr-like; cd12108 572418007916 Fe binding site [ion binding]; other site 572418007917 PE family; Region: PE; pfam00934 572418007918 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 572418007919 P-loop motif; other site 572418007920 ATP binding site [chemical binding]; other site 572418007921 Chloramphenicol (Cm) binding site [chemical binding]; other site 572418007922 catalytic residue [active] 572418007924 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 572418007925 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 572418007926 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572418007927 anti sigma factor interaction site; other site 572418007928 regulatory phosphorylation site [posttranslational modification]; other site 572418007929 hypothetical protein; Provisional; Region: PRK02237 572418007930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418007931 Transcriptional regulators [Transcription]; Region: MarR; COG1846 572418007932 putative DNA binding site [nucleotide binding]; other site 572418007933 putative Zn2+ binding site [ion binding]; other site 572418007934 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 572418007935 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 572418007936 putative metal binding site [ion binding]; other site 572418007937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418007938 dimerization interface [polypeptide binding]; other site 572418007939 putative DNA binding site [nucleotide binding]; other site 572418007940 putative Zn2+ binding site [ion binding]; other site 572418007942 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 572418007943 arsenical-resistance protein; Region: acr3; TIGR00832 572418007944 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 572418007945 Low molecular weight phosphatase family; Region: LMWPc; cd00115 572418007946 active site 572418007947 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418007948 MULE transposase domain; Region: MULE; pfam10551 572418007950 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 572418007951 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 572418007952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418007953 Coenzyme A binding pocket [chemical binding]; other site 572418007954 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 572418007956 hypothetical protein; Provisional; Region: PRK14059 572418007957 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 572418007958 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418007959 TAP-like protein; Region: Abhydrolase_4; pfam08386 572418007960 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 572418007961 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 572418007962 SelR domain; Region: SelR; pfam01641 572418007963 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572418007964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418007965 S-adenosylmethionine binding site [chemical binding]; other site 572418007966 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 572418007967 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 572418007968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418007969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418007970 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 572418007971 substrate binding site [chemical binding]; other site 572418007972 active site 572418007974 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418007975 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 572418007976 substrate binding site [chemical binding]; other site 572418007977 oxyanion hole (OAH) forming residues; other site 572418007978 trimer interface [polypeptide binding]; other site 572418007980 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 572418007981 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 572418007982 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 572418007983 catalytic site [active] 572418007984 putative active site [active] 572418007985 putative substrate binding site [chemical binding]; other site 572418007986 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 572418007987 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 572418007988 TPP-binding site; other site 572418007989 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572418007990 PYR/PP interface [polypeptide binding]; other site 572418007991 dimer interface [polypeptide binding]; other site 572418007992 TPP binding site [chemical binding]; other site 572418007993 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572418007994 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 572418007995 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572418007996 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 572418007997 transmembrane helices; other site 572418007998 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572418007999 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 572418008001 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 572418008002 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 572418008003 Walker A/P-loop; other site 572418008004 ATP binding site [chemical binding]; other site 572418008005 Q-loop/lid; other site 572418008006 ABC transporter signature motif; other site 572418008007 Walker B; other site 572418008008 D-loop; other site 572418008009 H-loop/switch region; other site 572418008011 TRAM domain; Region: TRAM; cl01282 572418008012 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 572418008013 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 572418008014 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572418008015 TrkA-N domain; Region: TrkA_N; pfam02254 572418008016 TrkA-C domain; Region: TrkA_C; pfam02080 572418008017 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572418008018 TrkA-N domain; Region: TrkA_N; pfam02254 572418008019 TrkA-C domain; Region: TrkA_C; pfam02080 572418008020 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 572418008021 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 572418008022 generic binding surface II; other site 572418008023 ssDNA binding site; other site 572418008024 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 572418008025 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 572418008026 trimer interface [polypeptide binding]; other site 572418008027 active site 572418008028 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 572418008029 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 572418008030 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 572418008031 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 572418008032 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 572418008033 active site 572418008034 dimerization interface [polypeptide binding]; other site 572418008037 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 572418008038 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 572418008039 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 572418008040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418008041 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572418008042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418008043 DNA binding residues [nucleotide binding] 572418008045 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 572418008046 homotrimer interaction site [polypeptide binding]; other site 572418008047 putative active site [active] 572418008048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 572418008049 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 572418008050 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 572418008051 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 572418008052 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 572418008053 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 572418008054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418008055 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572418008056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418008057 DNA binding residues [nucleotide binding] 572418008059 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 572418008060 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 572418008061 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 572418008062 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 572418008064 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 572418008065 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 572418008066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418008067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418008068 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572418008070 PAC2 family; Region: PAC2; pfam09754 572418008071 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418008072 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 572418008074 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 572418008075 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 572418008076 heme-binding site [chemical binding]; other site 572418008077 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 572418008078 ATP cone domain; Region: ATP-cone; pfam03477 572418008079 LysM domain; Region: LysM; pfam01476 572418008080 LexA repressor; Validated; Region: PRK00215 572418008081 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 572418008082 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 572418008083 Catalytic site [active] 572418008084 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 572418008085 LGFP repeat; Region: LGFP; pfam08310 572418008086 LGFP repeat; Region: LGFP; pfam08310 572418008087 LGFP repeat; Region: LGFP; pfam08310 572418008088 LGFP repeat; Region: LGFP; pfam08310 572418008089 LGFP repeat; Region: LGFP; pfam08310 572418008090 Integral membrane protein TerC family; Region: TerC; cl10468 572418008091 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418008092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418008093 active site 572418008095 GTPases [General function prediction only]; Region: HflX; COG2262 572418008096 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 572418008097 HflX GTPase family; Region: HflX; cd01878 572418008098 G1 box; other site 572418008099 GTP/Mg2+ binding site [chemical binding]; other site 572418008100 Switch I region; other site 572418008101 G2 box; other site 572418008102 G3 box; other site 572418008103 Switch II region; other site 572418008104 G4 box; other site 572418008105 G5 box; other site 572418008107 diaminopimelate epimerase; Region: DapF; TIGR00652 572418008108 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572418008109 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 572418008110 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 572418008111 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 572418008113 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 572418008114 active site 572418008115 metal binding site [ion binding]; metal-binding site 572418008116 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 572418008117 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 572418008118 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 572418008119 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 572418008120 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 572418008121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418008122 FeS/SAM binding site; other site 572418008123 TRAM domain; Region: TRAM; cl01282 572418008124 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418008125 FeS/SAM binding site; other site 572418008126 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 572418008127 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 572418008128 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 572418008129 hexamer interface [polypeptide binding]; other site 572418008130 Walker A motif; other site 572418008131 ATP binding site [chemical binding]; other site 572418008132 Walker B motif; other site 572418008133 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 572418008134 protein-splicing catalytic site; other site 572418008135 thioester formation/cholesterol transfer; other site 572418008136 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 572418008137 recA bacterial DNA recombination protein; Region: RecA; cl17211 572418008140 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 572418008141 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 572418008142 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 572418008143 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 572418008144 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 572418008146 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 572418008147 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 572418008148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418008149 non-specific DNA binding site [nucleotide binding]; other site 572418008150 salt bridge; other site 572418008151 sequence-specific DNA binding site [nucleotide binding]; other site 572418008152 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 572418008154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418008155 Coenzyme A binding pocket [chemical binding]; other site 572418008156 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 572418008157 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418008158 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 572418008160 Uncharacterized conserved protein [Function unknown]; Region: COG1359 572418008161 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 572418008162 classical (c) SDRs; Region: SDR_c; cd05233 572418008163 NAD(P) binding site [chemical binding]; other site 572418008164 active site 572418008165 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418008166 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418008167 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 572418008168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572418008169 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 572418008170 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 572418008171 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 572418008172 dimer interface [polypeptide binding]; other site 572418008173 active site 572418008174 catalytic residue [active] 572418008177 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 572418008178 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572418008179 HsdM N-terminal domain; Region: HsdM_N; pfam12161 572418008180 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 572418008181 Methyltransferase domain; Region: Methyltransf_26; pfam13659 572418008182 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 572418008183 putative active site [active] 572418008184 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 572418008186 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 572418008187 putative active site [active] 572418008188 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 572418008189 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572418008190 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 572418008191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 572418008192 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 572418008193 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 572418008194 folate binding site [chemical binding]; other site 572418008195 NADP+ binding site [chemical binding]; other site 572418008197 thymidylate synthase; Reviewed; Region: thyA; PRK01827 572418008198 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 572418008199 dimerization interface [polypeptide binding]; other site 572418008200 active site 572418008202 Dienelactone hydrolase family; Region: DLH; pfam01738 572418008203 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 572418008204 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 572418008205 classical (c) SDRs; Region: SDR_c; cd05233 572418008206 NAD(P) binding site [chemical binding]; other site 572418008207 active site 572418008209 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418008210 PPE family; Region: PPE; pfam00823 572418008211 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418008212 PE family; Region: PE; pfam00934 572418008213 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418008214 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418008215 PPE family; Region: PPE; pfam00823 572418008216 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 572418008217 dihydrodipicolinate reductase; Provisional; Region: PRK00048 572418008218 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 572418008219 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 572418008220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 572418008221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418008222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 572418008223 Coenzyme A binding pocket [chemical binding]; other site 572418008224 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 572418008225 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 572418008226 FMN-binding pocket [chemical binding]; other site 572418008227 flavin binding motif; other site 572418008228 phosphate binding motif [ion binding]; other site 572418008229 beta-alpha-beta structure motif; other site 572418008230 NAD binding pocket [chemical binding]; other site 572418008231 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572418008232 catalytic loop [active] 572418008233 iron binding site [ion binding]; other site 572418008236 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 572418008237 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 572418008238 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 572418008239 hydrophobic ligand binding site; other site 572418008240 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 572418008241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418008242 putative DNA binding site [nucleotide binding]; other site 572418008243 putative Zn2+ binding site [ion binding]; other site 572418008244 AsnC family; Region: AsnC_trans_reg; pfam01037 572418008248 Nitronate monooxygenase; Region: NMO; pfam03060 572418008249 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 572418008250 FMN binding site [chemical binding]; other site 572418008251 substrate binding site [chemical binding]; other site 572418008252 putative catalytic residue [active] 572418008253 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 572418008254 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 572418008255 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 572418008257 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 572418008258 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 572418008259 oligomer interface [polypeptide binding]; other site 572418008260 RNA binding site [nucleotide binding]; other site 572418008261 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 572418008262 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 572418008263 RNase E interface [polypeptide binding]; other site 572418008264 trimer interface [polypeptide binding]; other site 572418008265 active site 572418008266 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 572418008267 putative nucleic acid binding region [nucleotide binding]; other site 572418008268 G-X-X-G motif; other site 572418008269 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 572418008270 RNA binding site [nucleotide binding]; other site 572418008271 domain interface; other site 572418008273 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 572418008274 16S/18S rRNA binding site [nucleotide binding]; other site 572418008275 S13e-L30e interaction site [polypeptide binding]; other site 572418008276 25S rRNA binding site [nucleotide binding]; other site 572418008278 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 572418008279 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 572418008280 active site 572418008281 Riboflavin kinase; Region: Flavokinase; pfam01687 572418008282 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 572418008283 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 572418008285 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 572418008286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418008287 putative DNA binding site [nucleotide binding]; other site 572418008288 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 572418008289 FeoA domain; Region: FeoA; pfam04023 572418008290 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418008291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418008292 active site 572418008294 lipid-transfer protein; Provisional; Region: PRK08256 572418008295 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 572418008296 active site 572418008299 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572418008300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572418008301 Probable transposase; Region: OrfB_IS605; pfam01385 572418008302 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 572418008303 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 572418008304 catalytic residues [active] 572418008305 catalytic nucleophile [active] 572418008307 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 572418008308 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 572418008309 RNA binding site [nucleotide binding]; other site 572418008310 active site 572418008311 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 572418008312 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 572418008313 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 572418008314 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 572418008315 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 572418008316 active site 572418008317 metal binding site [ion binding]; metal-binding site 572418008318 Uncharacterized conserved protein [Function unknown]; Region: COG4717 572418008319 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 572418008321 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 572418008322 Predicted acyl esterases [General function prediction only]; Region: COG2936 572418008323 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 572418008324 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 572418008325 Uncharacterized conserved protein [Function unknown]; Region: COG5586 572418008326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 572418008327 Integrase core domain; Region: rve; pfam00665 572418008328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 572418008329 Transposase; Region: DDE_Tnp_ISL3; pfam01610 572418008330 Helix-turn-helix domain; Region: HTH_28; pfam13518 572418008331 Winged helix-turn helix; Region: HTH_29; pfam13551 572418008332 Integrase core domain; Region: rve; pfam00665 572418008333 Integrase core domain; Region: rve_3; cl15866 572418008334 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 572418008335 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 572418008337 putative transposase OrfB; Reviewed; Region: PHA02517 572418008338 HTH-like domain; Region: HTH_21; pfam13276 572418008339 Integrase core domain; Region: rve; pfam00665 572418008340 Integrase core domain; Region: rve_3; pfam13683 572418008341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572418008342 Transposase; Region: HTH_Tnp_1; cl17663 572418008343 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 572418008344 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 572418008346 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 572418008348 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 572418008349 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 572418008350 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 572418008351 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 572418008352 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 572418008353 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 572418008354 Uncharacterized conserved protein [Function unknown]; Region: COG2253 572418008355 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 572418008356 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 572418008357 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 572418008358 putative active site [active] 572418008359 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 572418008360 enoyl-CoA hydratase; Provisional; Region: PRK06190 572418008361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418008362 substrate binding site [chemical binding]; other site 572418008363 oxyanion hole (OAH) forming residues; other site 572418008364 trimer interface [polypeptide binding]; other site 572418008365 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 572418008366 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 572418008367 Walker A/P-loop; other site 572418008368 ATP binding site [chemical binding]; other site 572418008369 Q-loop/lid; other site 572418008370 ABC transporter signature motif; other site 572418008371 Walker B; other site 572418008372 D-loop; other site 572418008373 H-loop/switch region; other site 572418008376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 572418008377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 572418008378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 572418008379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418008380 dimer interface [polypeptide binding]; other site 572418008381 conserved gate region; other site 572418008382 putative PBP binding loops; other site 572418008383 ABC-ATPase subunit interface; other site 572418008385 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 572418008386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418008387 dimer interface [polypeptide binding]; other site 572418008388 conserved gate region; other site 572418008389 putative PBP binding loops; other site 572418008390 ABC-ATPase subunit interface; other site 572418008393 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 572418008394 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 572418008396 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 572418008397 DHH family; Region: DHH; pfam01368 572418008398 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 572418008399 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572418008400 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572418008401 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 572418008402 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 572418008403 G1 box; other site 572418008404 putative GEF interaction site [polypeptide binding]; other site 572418008405 GTP/Mg2+ binding site [chemical binding]; other site 572418008406 Switch I region; other site 572418008407 G2 box; other site 572418008408 G3 box; other site 572418008409 Switch II region; other site 572418008410 G4 box; other site 572418008411 G5 box; other site 572418008412 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 572418008413 Translation-initiation factor 2; Region: IF-2; pfam11987 572418008414 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 572418008416 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 572418008417 putative RNA binding cleft [nucleotide binding]; other site 572418008418 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 572418008419 NusA N-terminal domain; Region: NusA_N; pfam08529 572418008420 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 572418008421 RNA binding site [nucleotide binding]; other site 572418008422 homodimer interface [polypeptide binding]; other site 572418008423 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 572418008424 G-X-X-G motif; other site 572418008425 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 572418008426 G-X-X-G motif; other site 572418008427 ribosome maturation protein RimP; Reviewed; Region: PRK00092 572418008428 Sm and related proteins; Region: Sm_like; cl00259 572418008429 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 572418008430 putative oligomer interface [polypeptide binding]; other site 572418008431 putative RNA binding site [nucleotide binding]; other site 572418008432 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 572418008433 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 572418008434 dinuclear metal binding motif [ion binding]; other site 572418008435 prolyl-tRNA synthetase; Provisional; Region: PRK09194 572418008436 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 572418008437 dimer interface [polypeptide binding]; other site 572418008438 motif 1; other site 572418008439 active site 572418008440 motif 2; other site 572418008441 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 572418008442 putative deacylase active site [active] 572418008443 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572418008444 active site 572418008445 motif 3; other site 572418008446 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 572418008447 anticodon binding site; other site 572418008449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418008450 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572418008451 putative substrate translocation pore; other site 572418008452 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 572418008453 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 572418008454 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 572418008455 homodimer interface [polypeptide binding]; other site 572418008456 active site 572418008457 SAM binding site [chemical binding]; other site 572418008458 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 572418008459 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572418008460 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 572418008461 catalytic triad [active] 572418008462 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 572418008463 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 572418008464 homodimer interface [polypeptide binding]; other site 572418008465 Walker A motif; other site 572418008466 ATP binding site [chemical binding]; other site 572418008467 hydroxycobalamin binding site [chemical binding]; other site 572418008468 Walker B motif; other site 572418008469 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 572418008470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418008471 Walker A motif; other site 572418008472 ATP binding site [chemical binding]; other site 572418008473 Walker B motif; other site 572418008474 arginine finger; other site 572418008475 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 572418008476 metal ion-dependent adhesion site (MIDAS); other site 572418008477 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 572418008478 malate:quinone oxidoreductase; Validated; Region: PRK05257 572418008479 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 572418008480 PE family; Region: PE; pfam00934 572418008481 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 572418008482 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572418008483 mycothione reductase; Reviewed; Region: PRK07846 572418008484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418008485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418008486 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 572418008487 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 572418008488 short chain dehydrogenase; Provisional; Region: PRK06057 572418008489 classical (c) SDRs; Region: SDR_c; cd05233 572418008490 NAD(P) binding site [chemical binding]; other site 572418008491 active site 572418008492 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 572418008493 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 572418008494 NAD(P) binding site [chemical binding]; other site 572418008495 catalytic residues [active] 572418008498 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 572418008499 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 572418008500 catalytic triad [active] 572418008501 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 572418008502 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 572418008503 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 572418008504 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 572418008505 active site 572418008506 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 572418008507 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 572418008508 putative active site [active] 572418008509 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 572418008510 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 572418008511 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 572418008514 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 572418008515 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 572418008516 Predicted acetyltransferase [General function prediction only]; Region: COG3393 572418008517 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 572418008518 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 572418008519 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 572418008520 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 572418008521 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 572418008522 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 572418008523 active site 572418008524 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 572418008525 protein binding site [polypeptide binding]; other site 572418008526 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 572418008527 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 572418008528 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 572418008529 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 572418008531 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418008532 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418008533 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 572418008534 Fasciclin domain; Region: Fasciclin; pfam02469 572418008535 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 572418008536 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 572418008537 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 572418008538 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572418008539 catalytic residues [active] 572418008540 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 572418008541 Fasciclin domain; Region: Fasciclin; pfam02469 572418008542 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 572418008543 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 572418008545 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 572418008546 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572418008547 catalytic residues [active] 572418008548 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 572418008549 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418008550 FeS/SAM binding site; other site 572418008551 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 572418008552 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 572418008554 ribosome recycling factor; Reviewed; Region: frr; PRK00083 572418008555 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 572418008556 hinge region; other site 572418008557 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 572418008558 putative nucleotide binding site [chemical binding]; other site 572418008559 uridine monophosphate binding site [chemical binding]; other site 572418008560 homohexameric interface [polypeptide binding]; other site 572418008561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418008562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418008563 DNA binding site [nucleotide binding] 572418008566 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 572418008567 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 572418008568 catalytic residues [active] 572418008569 catalytic nucleophile [active] 572418008571 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 572418008572 MarR family; Region: MarR; pfam01047 572418008573 amidase; Provisional; Region: PRK07869 572418008574 Amidase; Region: Amidase; pfam01425 572418008576 elongation factor Ts; Provisional; Region: tsf; PRK09377 572418008577 UBA/TS-N domain; Region: UBA; pfam00627 572418008578 Elongation factor TS; Region: EF_TS; pfam00889 572418008579 Elongation factor TS; Region: EF_TS; pfam00889 572418008581 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 572418008582 rRNA interaction site [nucleotide binding]; other site 572418008583 S8 interaction site; other site 572418008584 putative laminin-1 binding site; other site 572418008587 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572418008588 Peptidase family M23; Region: Peptidase_M23; pfam01551 572418008590 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 572418008591 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418008592 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 572418008593 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572418008594 active site 572418008595 DNA binding site [nucleotide binding] 572418008596 Int/Topo IB signature motif; other site 572418008597 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 572418008598 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 572418008599 FAD binding pocket [chemical binding]; other site 572418008600 FAD binding motif [chemical binding]; other site 572418008601 phosphate binding motif [ion binding]; other site 572418008602 NAD binding pocket [chemical binding]; other site 572418008603 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 572418008604 DNA protecting protein DprA; Region: dprA; TIGR00732 572418008605 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 572418008606 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 572418008607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418008608 Walker A motif; other site 572418008609 ATP binding site [chemical binding]; other site 572418008610 Walker B motif; other site 572418008611 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 572418008613 hypothetical protein; Reviewed; Region: PRK12497 572418008614 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 572418008615 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 572418008616 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 572418008617 putative molybdopterin cofactor binding site [chemical binding]; other site 572418008618 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 572418008619 putative molybdopterin cofactor binding site; other site 572418008620 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 572418008621 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 572418008622 RNA/DNA hybrid binding site [nucleotide binding]; other site 572418008623 active site 572418008624 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 572418008625 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572418008626 Catalytic site [active] 572418008627 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572418008630 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 572418008631 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572418008632 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 572418008633 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 572418008634 RimM N-terminal domain; Region: RimM; pfam01782 572418008635 hypothetical protein; Provisional; Region: PRK02821 572418008636 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 572418008637 G-X-X-G motif; other site 572418008638 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 572418008639 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 572418008640 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 572418008641 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572418008642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418008643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418008644 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 572418008645 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 572418008646 active site 572418008647 putative substrate binding pocket [chemical binding]; other site 572418008648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 572418008649 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418008650 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418008651 active site 572418008652 ATP binding site [chemical binding]; other site 572418008653 substrate binding site [chemical binding]; other site 572418008654 activation loop (A-loop); other site 572418008655 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 572418008656 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 572418008657 active site 572418008658 signal recognition particle protein; Provisional; Region: PRK10867 572418008659 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 572418008660 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572418008661 P loop; other site 572418008662 GTP binding site [chemical binding]; other site 572418008663 Signal peptide binding domain; Region: SRP_SPB; pfam02978 572418008665 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 572418008666 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 572418008667 ATP binding site [chemical binding]; other site 572418008668 putative Mg++ binding site [ion binding]; other site 572418008670 PII uridylyl-transferase; Provisional; Region: PRK03381 572418008671 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 572418008672 metal binding triad; other site 572418008673 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 572418008674 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572418008675 Zn2+ binding site [ion binding]; other site 572418008676 Mg2+ binding site [ion binding]; other site 572418008677 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 572418008678 Nitrogen regulatory protein P-II; Region: P-II; smart00938 572418008679 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 572418008680 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 572418008681 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 572418008682 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 572418008685 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 572418008686 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 572418008687 Walker A/P-loop; other site 572418008688 ATP binding site [chemical binding]; other site 572418008689 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 572418008690 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 572418008691 ABC transporter signature motif; other site 572418008692 Walker B; other site 572418008693 D-loop; other site 572418008694 H-loop/switch region; other site 572418008696 acylphosphatase; Provisional; Region: PRK14422 572418008697 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 572418008698 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 572418008699 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 572418008700 DNA binding site [nucleotide binding] 572418008701 catalytic residue [active] 572418008702 H2TH interface [polypeptide binding]; other site 572418008703 putative catalytic residues [active] 572418008704 turnover-facilitating residue; other site 572418008705 intercalation triad [nucleotide binding]; other site 572418008706 8OG recognition residue [nucleotide binding]; other site 572418008707 putative reading head residues; other site 572418008708 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 572418008709 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572418008710 ribonuclease III; Reviewed; Region: rnc; PRK00102 572418008711 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 572418008712 dimerization interface [polypeptide binding]; other site 572418008713 active site 572418008714 metal binding site [ion binding]; metal-binding site 572418008715 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 572418008716 dsRNA binding site [nucleotide binding]; other site 572418008718 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 572418008719 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 572418008720 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 572418008721 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 572418008722 acyl-CoA synthetase; Validated; Region: PRK05850 572418008723 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418008724 acyl-activating enzyme (AAE) consensus motif; other site 572418008725 active site 572418008726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572418008727 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418008728 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418008729 active site 572418008730 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 572418008731 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418008732 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 572418008733 NADP binding site [chemical binding]; other site 572418008734 KR domain; Region: KR; pfam08659 572418008735 active site 572418008736 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418008739 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418008740 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 572418008741 active site 572418008742 Acyl transferase domain; Region: Acyl_transf_1; cl08282 572418008743 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 572418008744 KR domain; Region: KR; pfam08659 572418008745 NADP binding site [chemical binding]; other site 572418008746 active site 572418008747 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418008749 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418008750 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418008751 active site 572418008752 Acyl transferase domain; Region: Acyl_transf_1; cl08282 572418008753 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418008754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418008755 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 572418008756 Enoylreductase; Region: PKS_ER; smart00829 572418008757 NAD(P) binding site [chemical binding]; other site 572418008758 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 572418008759 KR domain; Region: KR; pfam08659 572418008760 putative NADP binding site [chemical binding]; other site 572418008761 active site 572418008762 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418008765 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418008766 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418008767 active site 572418008768 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418008769 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418008770 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 572418008771 KR domain; Region: KR; pfam08659 572418008772 putative NADP binding site [chemical binding]; other site 572418008773 active site 572418008774 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418008779 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418008780 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418008781 active site 572418008782 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418008783 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 572418008784 Condensation domain; Region: Condensation; pfam00668 572418008785 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 572418008787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418008788 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 572418008789 Walker A/P-loop; other site 572418008790 ATP binding site [chemical binding]; other site 572418008791 Q-loop/lid; other site 572418008792 ABC transporter signature motif; other site 572418008793 Walker B; other site 572418008794 D-loop; other site 572418008795 H-loop/switch region; other site 572418008798 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 572418008799 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 572418008800 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 572418008801 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 572418008802 acyltransferase PapA5; Provisional; Region: PRK09294 572418008803 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418008804 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418008805 active site 572418008806 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 572418008807 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418008808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418008809 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 572418008810 Enoylreductase; Region: PKS_ER; smart00829 572418008811 NAD(P) binding site [chemical binding]; other site 572418008812 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 572418008813 KR domain; Region: KR; pfam08659 572418008814 putative NADP binding site [chemical binding]; other site 572418008815 active site 572418008816 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418008819 acyl-CoA synthetase; Validated; Region: PRK05850 572418008820 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418008821 acyl-activating enzyme (AAE) consensus motif; other site 572418008822 active site 572418008824 MMPL family; Region: MMPL; pfam03176 572418008828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 572418008829 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 572418008830 Integrase core domain; Region: rve; pfam00665 572418008831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 572418008832 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 572418008833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418008834 ATP binding site [chemical binding]; other site 572418008835 Walker A motif; other site 572418008836 Walker B motif; other site 572418008838 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 572418008840 Erythronolide synthase docking; Region: Docking; pfam08990 572418008841 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418008842 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418008843 active site 572418008844 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418008845 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418008846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418008847 Enoylreductase; Region: PKS_ER; smart00829 572418008848 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 572418008849 NAD(P) binding site [chemical binding]; other site 572418008850 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 572418008851 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 572418008852 putative NADP binding site [chemical binding]; other site 572418008853 active site 572418008854 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418008857 acyl-CoA synthetase; Validated; Region: PRK06060 572418008858 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 572418008859 dimer interface [polypeptide binding]; other site 572418008860 acyl-activating enzyme (AAE) consensus motif; other site 572418008861 putative active site [active] 572418008862 putative AMP binding site [chemical binding]; other site 572418008863 putative CoA binding site [chemical binding]; other site 572418008864 chemical substrate binding site [chemical binding]; other site 572418008865 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418008866 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 572418008867 acyl-CoA synthetase; Validated; Region: PRK05850 572418008868 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418008869 acyl-activating enzyme (AAE) consensus motif; other site 572418008870 active site 572418008871 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 572418008872 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418008873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418008874 S-adenosylmethionine binding site [chemical binding]; other site 572418008875 Uncharacterized conserved protein [Function unknown]; Region: COG3268 572418008876 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572418008877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418008878 S-adenosylmethionine binding site [chemical binding]; other site 572418008879 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 572418008880 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 572418008881 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 572418008882 metal-binding site 572418008884 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 572418008885 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 572418008886 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 572418008887 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 572418008888 active site 572418008889 TDP-binding site; other site 572418008890 acceptor substrate-binding pocket; other site 572418008891 Predicted permease; Region: DUF318; pfam03773 572418008892 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 572418008893 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 572418008894 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 572418008895 putative active site [active] 572418008896 putative substrate binding site [chemical binding]; other site 572418008897 putative cosubstrate binding site; other site 572418008898 catalytic site [active] 572418008899 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 572418008900 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 572418008901 active site 572418008902 (T/H)XGH motif; other site 572418008903 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 572418008904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418008905 S-adenosylmethionine binding site [chemical binding]; other site 572418008907 pyruvate carboxylase; Reviewed; Region: PRK12999 572418008908 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572418008909 ATP-grasp domain; Region: ATP-grasp_4; cl17255 572418008910 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572418008911 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 572418008912 active site 572418008913 catalytic residues [active] 572418008914 metal binding site [ion binding]; metal-binding site 572418008915 homodimer binding site [polypeptide binding]; other site 572418008916 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572418008917 carboxyltransferase (CT) interaction site; other site 572418008918 biotinylation site [posttranslational modification]; other site 572418008922 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 572418008923 putative active site [active] 572418008924 redox center [active] 572418008925 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 572418008926 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 572418008927 catalytic residues [active] 572418008928 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 572418008929 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418008930 substrate binding pocket [chemical binding]; other site 572418008931 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 572418008932 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 572418008933 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 572418008934 active site 572418008935 catalytic tetrad [active] 572418008938 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 572418008939 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 572418008940 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 572418008941 generic binding surface II; other site 572418008942 ssDNA binding site; other site 572418008943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418008944 ATP binding site [chemical binding]; other site 572418008945 putative Mg++ binding site [ion binding]; other site 572418008946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418008947 nucleotide binding region [chemical binding]; other site 572418008948 ATP-binding site [chemical binding]; other site 572418008950 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 572418008951 DAK2 domain; Region: Dak2; cl03685 572418008952 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 572418008953 ligand binding site [chemical binding]; other site 572418008954 active site 572418008955 UGI interface [polypeptide binding]; other site 572418008956 catalytic site [active] 572418008957 thiamine monophosphate kinase; Provisional; Region: PRK05731 572418008958 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 572418008959 ATP binding site [chemical binding]; other site 572418008960 dimerization interface [polypeptide binding]; other site 572418008961 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572418008962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572418008963 Probable transposase; Region: OrfB_IS605; pfam01385 572418008964 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 572418008965 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 572418008966 catalytic residues [active] 572418008967 catalytic nucleophile [active] 572418008969 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 572418008970 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 572418008971 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 572418008972 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 572418008974 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 572418008975 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 572418008976 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 572418008977 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 572418008978 polyphosphate kinase; Provisional; Region: PRK05443 572418008979 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 572418008980 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 572418008981 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 572418008982 putative domain interface [polypeptide binding]; other site 572418008983 putative active site [active] 572418008984 catalytic site [active] 572418008985 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 572418008986 putative domain interface [polypeptide binding]; other site 572418008987 putative active site [active] 572418008988 catalytic site [active] 572418008989 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 572418008990 active site 572418008991 Ap6A binding site [chemical binding]; other site 572418008992 nudix motif; other site 572418008993 metal binding site [ion binding]; metal-binding site 572418008994 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418008995 catalytic core [active] 572418008997 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 572418008998 IHF - DNA interface [nucleotide binding]; other site 572418008999 IHF dimer interface [polypeptide binding]; other site 572418009001 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 572418009002 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 572418009003 substrate binding site [chemical binding]; other site 572418009004 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 572418009005 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 572418009006 substrate binding site [chemical binding]; other site 572418009007 ligand binding site [chemical binding]; other site 572418009009 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 572418009010 Transcriptional regulator [Transcription]; Region: IclR; COG1414 572418009011 Bacterial transcriptional regulator; Region: IclR; pfam01614 572418009012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418009013 S-adenosylmethionine binding site [chemical binding]; other site 572418009014 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 572418009015 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 572418009016 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 572418009017 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572418009018 active site 572418009019 HIGH motif; other site 572418009020 nucleotide binding site [chemical binding]; other site 572418009021 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 572418009022 active site 572418009023 KMSKS motif; other site 572418009024 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 572418009025 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 572418009026 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 572418009027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418009028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572418009029 putative substrate translocation pore; other site 572418009030 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 572418009031 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 572418009032 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 572418009033 ligand binding site [chemical binding]; other site 572418009034 NAD binding site [chemical binding]; other site 572418009035 dimerization interface [polypeptide binding]; other site 572418009036 catalytic site [active] 572418009037 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 572418009038 putative L-serine binding site [chemical binding]; other site 572418009042 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 572418009043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418009044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 572418009045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 572418009046 phosphorylation site [posttranslational modification] 572418009047 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 572418009048 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 572418009050 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 572418009052 ketol-acid reductoisomerase; Provisional; Region: PRK05479 572418009053 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 572418009054 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 572418009055 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 572418009056 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 572418009057 putative valine binding site [chemical binding]; other site 572418009058 dimer interface [polypeptide binding]; other site 572418009059 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 572418009060 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 572418009061 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572418009062 PYR/PP interface [polypeptide binding]; other site 572418009063 dimer interface [polypeptide binding]; other site 572418009064 TPP binding site [chemical binding]; other site 572418009065 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572418009066 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 572418009067 TPP-binding site [chemical binding]; other site 572418009068 dimer interface [polypeptide binding]; other site 572418009070 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 572418009071 Predicted membrane protein [Function unknown]; Region: COG2259 572418009072 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 572418009074 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 572418009075 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 572418009076 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 572418009077 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 572418009078 GatB domain; Region: GatB_Yqey; smart00845 572418009080 6-phosphofructokinase; Provisional; Region: PRK03202 572418009081 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 572418009082 active site 572418009083 ADP/pyrophosphate binding site [chemical binding]; other site 572418009084 dimerization interface [polypeptide binding]; other site 572418009085 allosteric effector site; other site 572418009086 fructose-1,6-bisphosphate binding site; other site 572418009088 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 572418009089 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 572418009091 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 572418009092 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 572418009093 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 572418009094 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 572418009095 nucleotide binding pocket [chemical binding]; other site 572418009096 K-X-D-G motif; other site 572418009097 catalytic site [active] 572418009098 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 572418009099 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 572418009100 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 572418009101 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 572418009102 Dimer interface [polypeptide binding]; other site 572418009103 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 572418009104 PknH-like extracellular domain; Region: PknH_C; pfam14032 572418009106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 572418009107 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418009108 PPE family; Region: PPE; pfam00823 572418009109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 572418009110 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418009111 PPE family; Region: PPE; pfam00823 572418009112 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418009113 MULE transposase domain; Region: MULE; pfam10551 572418009114 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 572418009115 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 572418009116 Ligand Binding Site [chemical binding]; other site 572418009117 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 572418009118 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 572418009119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418009120 catalytic residue [active] 572418009122 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418009123 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572418009124 putative acyl-acceptor binding pocket; other site 572418009125 Putative hemolysin [General function prediction only]; Region: COG3176 572418009126 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 572418009127 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 572418009128 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 572418009129 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 572418009130 Ligand binding site [chemical binding]; other site 572418009131 Electron transfer flavoprotein domain; Region: ETF; pfam01012 572418009132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418009133 Methyltransferase domain; Region: Methyltransf_31; pfam13847 572418009134 S-adenosylmethionine binding site [chemical binding]; other site 572418009135 Uncharacterized conserved protein [Function unknown]; Region: COG1543 572418009136 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 572418009137 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 572418009138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572418009139 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572418009140 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 572418009141 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 572418009142 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 572418009143 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 572418009144 trimer interface [polypeptide binding]; other site 572418009145 active site 572418009146 substrate binding site [chemical binding]; other site 572418009147 CoA binding site [chemical binding]; other site 572418009148 FOG: WD40-like repeat [Function unknown]; Region: COG1520 572418009149 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 572418009150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418009151 S-adenosylmethionine binding site [chemical binding]; other site 572418009153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418009154 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 572418009155 substrate binding site [chemical binding]; other site 572418009156 oxyanion hole (OAH) forming residues; other site 572418009157 trimer interface [polypeptide binding]; other site 572418009158 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 572418009159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418009160 Walker A/P-loop; other site 572418009161 ATP binding site [chemical binding]; other site 572418009162 Q-loop/lid; other site 572418009163 ABC transporter signature motif; other site 572418009164 Walker B; other site 572418009165 D-loop; other site 572418009166 H-loop/switch region; other site 572418009168 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 572418009169 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 572418009170 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 572418009171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418009172 motif II; other site 572418009173 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 572418009174 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 572418009175 D-pathway; other site 572418009176 Putative ubiquinol binding site [chemical binding]; other site 572418009177 Low-spin heme (heme b) binding site [chemical binding]; other site 572418009178 Putative water exit pathway; other site 572418009179 Binuclear center (heme o3/CuB) [ion binding]; other site 572418009180 K-pathway; other site 572418009181 Putative proton exit pathway; other site 572418009182 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 572418009183 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 572418009184 siderophore binding site; other site 572418009186 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 572418009187 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 572418009188 putative NAD(P) binding site [chemical binding]; other site 572418009189 putative substrate binding site [chemical binding]; other site 572418009190 catalytic Zn binding site [ion binding]; other site 572418009191 structural Zn binding site [ion binding]; other site 572418009192 dimer interface [polypeptide binding]; other site 572418009194 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 572418009195 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 572418009196 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 572418009197 dimer interface [polypeptide binding]; other site 572418009198 putative radical transfer pathway; other site 572418009199 diiron center [ion binding]; other site 572418009200 tyrosyl radical; other site 572418009202 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418009203 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572418009204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418009205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009206 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 572418009207 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 572418009208 Class I ribonucleotide reductase; Region: RNR_I; cd01679 572418009209 active site 572418009210 dimer interface [polypeptide binding]; other site 572418009211 catalytic residues [active] 572418009212 effector binding site; other site 572418009213 R2 peptide binding site; other site 572418009215 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 572418009216 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 572418009217 catalytic residues [active] 572418009218 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 572418009219 Predicted flavoprotein [General function prediction only]; Region: COG0431 572418009221 DNA polymerase IV; Validated; Region: PRK03352 572418009222 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 572418009223 active site 572418009224 DNA binding site [nucleotide binding] 572418009225 short chain dehydrogenase; Provisional; Region: PRK07832 572418009226 classical (c) SDRs; Region: SDR_c; cd05233 572418009227 NAD(P) binding site [chemical binding]; other site 572418009228 active site 572418009230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418009231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009232 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418009233 Cytochrome P450; Region: p450; cl12078 572418009235 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572418009236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572418009237 DNA-binding site [nucleotide binding]; DNA binding site 572418009238 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 572418009239 Transcriptional regulators [Transcription]; Region: FadR; COG2186 572418009240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 572418009241 DNA-binding site [nucleotide binding]; DNA binding site 572418009242 FCD domain; Region: FCD; pfam07729 572418009244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418009245 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 572418009246 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418009247 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418009248 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418009249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418009250 active site 572418009251 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 572418009252 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 572418009253 active site 572418009254 DNA binding site [nucleotide binding] 572418009255 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 572418009256 DNA binding site [nucleotide binding] 572418009259 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 572418009260 Carbon starvation protein CstA; Region: CstA; pfam02554 572418009261 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 572418009262 Predicted membrane protein [Function unknown]; Region: COG2259 572418009263 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 572418009264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 572418009265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009266 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418009267 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 572418009268 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 572418009269 active site 572418009270 substrate binding site [chemical binding]; other site 572418009271 metal binding site [ion binding]; metal-binding site 572418009274 camphor resistance protein CrcB; Provisional; Region: PRK14216 572418009275 camphor resistance protein CrcB; Provisional; Region: PRK14228 572418009276 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 572418009277 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 572418009278 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 572418009279 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418009280 Uncharacterized conserved protein [Function unknown]; Region: COG3189 572418009281 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418009282 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418009283 active site 572418009284 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 572418009285 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 572418009286 putative hydrophobic ligand binding site [chemical binding]; other site 572418009287 protein interface [polypeptide binding]; other site 572418009288 gate; other site 572418009289 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 572418009290 Sulfatase; Region: Sulfatase; pfam00884 572418009291 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 572418009292 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418009293 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 572418009294 Catalytic domain of Protein Kinases; Region: PKc; cd00180 572418009295 active site 572418009296 ATP binding site [chemical binding]; other site 572418009297 substrate binding site [chemical binding]; other site 572418009298 activation loop (A-loop); other site 572418009299 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 572418009300 AAA ATPase domain; Region: AAA_16; pfam13191 572418009303 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 572418009305 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 572418009306 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572418009307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572418009308 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418009309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572418009310 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 572418009311 short chain dehydrogenase; Provisional; Region: PRK07832 572418009312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418009313 NAD(P) binding site [chemical binding]; other site 572418009314 active site 572418009316 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 572418009317 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 572418009318 NAD binding site [chemical binding]; other site 572418009319 catalytic Zn binding site [ion binding]; other site 572418009320 substrate binding site [chemical binding]; other site 572418009321 structural Zn binding site [ion binding]; other site 572418009323 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418009324 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418009325 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418009326 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418009327 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 572418009328 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 572418009329 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418009330 acyl-activating enzyme (AAE) consensus motif; other site 572418009331 AMP binding site [chemical binding]; other site 572418009332 active site 572418009333 CoA binding site [chemical binding]; other site 572418009336 SPFH domain / Band 7 family; Region: Band_7; pfam01145 572418009337 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 572418009338 Patatin-like phospholipase; Region: Patatin; pfam01734 572418009339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 572418009340 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 572418009341 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418009342 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418009343 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418009344 active site 572418009345 Predicted transcriptional regulators [Transcription]; Region: COG1733 572418009346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418009347 dimerization interface [polypeptide binding]; other site 572418009348 putative DNA binding site [nucleotide binding]; other site 572418009349 putative Zn2+ binding site [ion binding]; other site 572418009350 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 572418009352 PE family; Region: PE; pfam00934 572418009353 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418009354 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 572418009355 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 572418009356 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 572418009357 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 572418009358 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 572418009359 SmpB-tmRNA interface; other site 572418009360 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 572418009361 FtsX-like permease family; Region: FtsX; pfam02687 572418009362 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 572418009363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 572418009364 Walker A/P-loop; other site 572418009365 ATP binding site [chemical binding]; other site 572418009366 Q-loop/lid; other site 572418009367 ABC transporter signature motif; other site 572418009368 Walker B; other site 572418009369 D-loop; other site 572418009370 H-loop/switch region; other site 572418009373 Mechanosensitive ion channel; Region: MS_channel; pfam00924 572418009374 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 572418009375 peptide chain release factor 2; Validated; Region: prfB; PRK00578 572418009376 This domain is found in peptide chain release factors; Region: PCRF; smart00937 572418009377 RF-1 domain; Region: RF-1; pfam00472 572418009379 ferredoxin-NADP+ reductase; Region: PLN02852 572418009380 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418009381 FAD binding domain; Region: FAD_binding_4; pfam01565 572418009382 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 572418009383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418009384 FeS/SAM binding site; other site 572418009385 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 572418009386 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 572418009387 aromatic arch; other site 572418009388 DCoH dimer interaction site [polypeptide binding]; other site 572418009389 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 572418009390 DCoH tetramer interaction site [polypeptide binding]; other site 572418009391 substrate binding site [chemical binding]; other site 572418009392 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 572418009393 trimer interface [polypeptide binding]; other site 572418009394 dimer interface [polypeptide binding]; other site 572418009395 putative active site [active] 572418009396 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572418009397 MoaE interaction surface [polypeptide binding]; other site 572418009398 MoeB interaction surface [polypeptide binding]; other site 572418009399 thiocarboxylated glycine; other site 572418009400 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 572418009401 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 572418009402 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 572418009403 nucleoside/Zn binding site; other site 572418009404 dimer interface [polypeptide binding]; other site 572418009405 catalytic motif [active] 572418009406 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418009407 MULE transposase domain; Region: MULE; pfam10551 572418009408 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 572418009409 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 572418009410 ATP binding site [chemical binding]; other site 572418009411 substrate interface [chemical binding]; other site 572418009412 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572418009413 active site residue [active] 572418009414 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 572418009415 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 572418009416 active site residue [active] 572418009417 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 572418009418 active site residue [active] 572418009419 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 572418009420 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 572418009421 MoaE homodimer interface [polypeptide binding]; other site 572418009422 MoaD interaction [polypeptide binding]; other site 572418009423 active site residues [active] 572418009424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418009425 S-adenosylmethionine binding site [chemical binding]; other site 572418009428 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 572418009429 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 572418009430 DNA binding site [nucleotide binding] 572418009431 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418009432 PPE family; Region: PPE; pfam00823 572418009433 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 572418009435 putative transposase OrfB; Reviewed; Region: PHA02517 572418009436 HTH-like domain; Region: HTH_21; pfam13276 572418009437 Integrase core domain; Region: rve; pfam00665 572418009438 Integrase core domain; Region: rve_3; pfam13683 572418009439 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 572418009440 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418009441 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418009442 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 572418009443 dimer interface [polypeptide binding]; other site 572418009444 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 572418009445 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 572418009446 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 572418009447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 572418009448 Histidine kinase; Region: HisKA_3; pfam07730 572418009449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418009450 ATP binding site [chemical binding]; other site 572418009451 Mg2+ binding site [ion binding]; other site 572418009452 G-X-G motif; other site 572418009453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 572418009454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418009455 active site 572418009456 phosphorylation site [posttranslational modification] 572418009457 intermolecular recognition site; other site 572418009458 dimerization interface [polypeptide binding]; other site 572418009459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 572418009460 DNA binding residues [nucleotide binding] 572418009461 dimerization interface [polypeptide binding]; other site 572418009463 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 572418009464 Ligand Binding Site [chemical binding]; other site 572418009465 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418009466 PPE family; Region: PPE; pfam00823 572418009467 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418009468 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418009469 PPE family; Region: PPE; pfam00823 572418009470 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418009471 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 572418009472 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 572418009473 active site 572418009475 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 572418009476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418009477 FeS/SAM binding site; other site 572418009478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418009479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418009480 active site 572418009482 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418009483 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418009484 active site 572418009485 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 572418009486 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 572418009487 NAD(P) binding site [chemical binding]; other site 572418009488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418009489 active site 572418009490 phosphorylation site [posttranslational modification] 572418009491 intermolecular recognition site; other site 572418009492 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418009493 PPE family; Region: PPE; pfam00823 572418009494 NADH dehydrogenase subunit A; Validated; Region: PRK07928 572418009495 NADH dehydrogenase subunit B; Validated; Region: PRK06411 572418009496 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 572418009497 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 572418009498 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 572418009499 NADH dehydrogenase subunit D; Validated; Region: PRK06075 572418009500 NADH dehydrogenase subunit E; Validated; Region: PRK07539 572418009501 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 572418009502 putative dimer interface [polypeptide binding]; other site 572418009503 [2Fe-2S] cluster binding site [ion binding]; other site 572418009504 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 572418009505 SLBB domain; Region: SLBB; pfam10531 572418009506 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 572418009508 NADH dehydrogenase subunit G; Validated; Region: PRK07860 572418009509 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572418009510 catalytic loop [active] 572418009511 iron binding site [ion binding]; other site 572418009512 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 572418009513 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 572418009514 [4Fe-4S] binding site [ion binding]; other site 572418009515 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 572418009517 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 572418009518 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 572418009520 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 572418009521 4Fe-4S binding domain; Region: Fer4; pfam00037 572418009522 4Fe-4S binding domain; Region: Fer4; pfam00037 572418009525 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 572418009526 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 572418009527 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 572418009528 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 572418009529 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572418009530 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 572418009531 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572418009532 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 572418009533 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 572418009534 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418009535 PPE family; Region: PPE; pfam00823 572418009536 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418009537 PPE family; Region: PPE; pfam00823 572418009538 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 572418009539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009540 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 572418009541 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 572418009542 [2Fe-2S] cluster binding site [ion binding]; other site 572418009543 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 572418009544 putative alpha subunit interface [polypeptide binding]; other site 572418009545 putative active site [active] 572418009546 putative substrate binding site [chemical binding]; other site 572418009547 Fe binding site [ion binding]; other site 572418009548 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 572418009549 Protein of unknown function DUF58; Region: DUF58; pfam01882 572418009551 MoxR-like ATPases [General function prediction only]; Region: COG0714 572418009552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418009553 Walker A motif; other site 572418009554 ATP binding site [chemical binding]; other site 572418009555 Walker B motif; other site 572418009556 arginine finger; other site 572418009557 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 572418009558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418009559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009560 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 572418009561 putative active site [active] 572418009562 putative substrate binding site [chemical binding]; other site 572418009563 ATP binding site [chemical binding]; other site 572418009564 Phosphotransferase enzyme family; Region: APH; pfam01636 572418009566 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 572418009567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418009568 hydroxyglutarate oxidase; Provisional; Region: PRK11728 572418009569 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418009570 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 572418009571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418009572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009573 short chain dehydrogenase; Validated; Region: PRK08264 572418009574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418009575 NAD(P) binding site [chemical binding]; other site 572418009576 active site 572418009577 amidase; Provisional; Region: PRK06170 572418009578 Amidase; Region: Amidase; pfam01425 572418009580 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418009581 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418009582 TAP-like protein; Region: Abhydrolase_4; pfam08386 572418009583 Domain of unknown function (DUF385); Region: DUF385; pfam04075 572418009584 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 572418009585 AAA domain; Region: AAA_14; pfam13173 572418009587 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 572418009588 putative active site [active] 572418009589 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 572418009590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 572418009591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 572418009592 non-specific DNA binding site [nucleotide binding]; other site 572418009593 salt bridge; other site 572418009594 sequence-specific DNA binding site [nucleotide binding]; other site 572418009595 RES domain; Region: RES; pfam08808 572418009596 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 572418009597 Helix-turn-helix domain; Region: HTH_38; pfam13936 572418009598 Integrase core domain; Region: rve; pfam00665 572418009599 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 572418009600 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572418009601 hypothetical protein; Validated; Region: PRK00068 572418009602 Uncharacterized conserved protein [Function unknown]; Region: COG1615 572418009603 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 572418009604 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 572418009605 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 572418009606 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572418009607 Uncharacterized conserved protein [Function unknown]; Region: COG5282 572418009608 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 572418009609 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 572418009610 ABC1 family; Region: ABC1; pfam03109 572418009611 Phosphotransferase enzyme family; Region: APH; pfam01636 572418009612 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 572418009613 active site 572418009614 ATP binding site [chemical binding]; other site 572418009616 Transcription factor WhiB; Region: Whib; pfam02467 572418009617 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 572418009618 Part of AAA domain; Region: AAA_19; pfam13245 572418009619 Family description; Region: UvrD_C_2; pfam13538 572418009620 HRDC domain; Region: HRDC; pfam00570 572418009622 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 572418009623 catalytic residues [active] 572418009624 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 572418009625 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 572418009626 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 572418009627 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 572418009628 putative NADH binding site [chemical binding]; other site 572418009629 putative active site [active] 572418009630 nudix motif; other site 572418009631 putative metal binding site [ion binding]; other site 572418009633 Ion channel; Region: Ion_trans_2; pfam07885 572418009634 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572418009635 TrkA-N domain; Region: TrkA_N; pfam02254 572418009637 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 572418009638 Part of AAA domain; Region: AAA_19; pfam13245 572418009639 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 572418009641 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 572418009642 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 572418009643 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 572418009644 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 572418009645 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 572418009647 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 572418009648 active site 572418009649 DNA binding site [nucleotide binding] 572418009650 TIGR02569 family protein; Region: TIGR02569_actnb 572418009651 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 572418009652 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 572418009653 ATP binding site [chemical binding]; other site 572418009654 substrate interface [chemical binding]; other site 572418009655 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 572418009656 active site residue [active] 572418009657 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 572418009659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418009660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009661 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 572418009662 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 572418009663 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 572418009664 DEAD-like helicases superfamily; Region: DEXDc; smart00487 572418009665 ATP binding site [chemical binding]; other site 572418009666 Mg++ binding site [ion binding]; other site 572418009667 motif III; other site 572418009668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418009669 nucleotide binding region [chemical binding]; other site 572418009670 ATP-binding site [chemical binding]; other site 572418009673 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572418009674 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572418009675 P-loop; other site 572418009676 Magnesium ion binding site [ion binding]; other site 572418009677 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572418009678 Magnesium ion binding site [ion binding]; other site 572418009679 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418009680 catalytic core [active] 572418009681 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 572418009682 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 572418009683 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 572418009684 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 572418009685 Transcription factor WhiB; Region: Whib; pfam02467 572418009686 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 572418009687 PAS domain S-box; Region: sensory_box; TIGR00229 572418009688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 572418009689 Histidine kinase; Region: HisKA_2; pfam07568 572418009690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418009691 ATP binding site [chemical binding]; other site 572418009692 Mg2+ binding site [ion binding]; other site 572418009693 G-X-G motif; other site 572418009694 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572418009695 carboxyltransferase (CT) interaction site; other site 572418009696 biotinylation site [posttranslational modification]; other site 572418009697 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 572418009698 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 572418009699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418009700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418009701 DNA binding residues [nucleotide binding] 572418009703 short chain dehydrogenase; Provisional; Region: PRK08278 572418009704 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 572418009705 NAD(P) binding site [chemical binding]; other site 572418009706 homodimer interface [polypeptide binding]; other site 572418009707 active site 572418009709 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 572418009710 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 572418009711 putative deacylase active site [active] 572418009712 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 572418009713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 572418009714 Coenzyme A binding pocket [chemical binding]; other site 572418009715 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 572418009716 Phosphotransferase enzyme family; Region: APH; pfam01636 572418009717 putative active site [active] 572418009718 putative substrate binding site [chemical binding]; other site 572418009719 ATP binding site [chemical binding]; other site 572418009720 Uncharacterized conserved protein [Function unknown]; Region: COG2135 572418009721 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 572418009722 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 572418009723 hinge; other site 572418009724 active site 572418009726 Predicted GTPases [General function prediction only]; Region: COG1162 572418009727 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 572418009728 GTPase/Zn-binding domain interface [polypeptide binding]; other site 572418009729 GTP/Mg2+ binding site [chemical binding]; other site 572418009730 G4 box; other site 572418009731 G5 box; other site 572418009732 G1 box; other site 572418009733 Switch I region; other site 572418009734 G2 box; other site 572418009735 G3 box; other site 572418009736 Switch II region; other site 572418009738 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 572418009739 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 572418009740 putative di-iron ligands [ion binding]; other site 572418009741 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 572418009742 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 572418009743 FAD binding pocket [chemical binding]; other site 572418009744 FAD binding motif [chemical binding]; other site 572418009745 phosphate binding motif [ion binding]; other site 572418009746 beta-alpha-beta structure motif; other site 572418009747 NAD binding pocket [chemical binding]; other site 572418009748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572418009749 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 572418009750 catalytic loop [active] 572418009751 iron binding site [ion binding]; other site 572418009752 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 572418009753 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418009754 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418009755 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 572418009756 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 572418009757 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 572418009758 TrkA-C domain; Region: TrkA_C; pfam02080 572418009759 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 572418009760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418009761 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572418009762 putative substrate translocation pore; other site 572418009763 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418009764 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418009765 ligand binding site [chemical binding]; other site 572418009766 flexible hinge region; other site 572418009767 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572418009768 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 572418009769 nucleophile elbow; other site 572418009772 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 572418009773 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 572418009774 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 572418009775 30S subunit binding site; other site 572418009776 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 572418009777 active site 572418009778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 572418009780 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 572418009781 lipoprotein LpqB; Provisional; Region: PRK13616 572418009782 Sporulation and spore germination; Region: Germane; pfam10646 572418009784 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 572418009785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418009786 dimerization interface [polypeptide binding]; other site 572418009787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572418009788 dimer interface [polypeptide binding]; other site 572418009789 phosphorylation site [posttranslational modification] 572418009790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418009791 ATP binding site [chemical binding]; other site 572418009792 Mg2+ binding site [ion binding]; other site 572418009793 G-X-G motif; other site 572418009794 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418009795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418009796 active site 572418009797 phosphorylation site [posttranslational modification] 572418009798 intermolecular recognition site; other site 572418009799 dimerization interface [polypeptide binding]; other site 572418009800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418009801 DNA binding site [nucleotide binding] 572418009802 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 572418009803 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 572418009804 TMP-binding site; other site 572418009805 ATP-binding site [chemical binding]; other site 572418009806 Adenosylhomocysteinase; Provisional; Region: PTZ00075 572418009807 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 572418009808 homotetramer interface [polypeptide binding]; other site 572418009809 ligand binding site [chemical binding]; other site 572418009810 catalytic site [active] 572418009811 NAD binding site [chemical binding]; other site 572418009813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009814 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 572418009815 Rubredoxin [Energy production and conversion]; Region: COG1773 572418009816 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 572418009817 iron binding site [ion binding]; other site 572418009819 Rubredoxin [Energy production and conversion]; Region: COG1773 572418009820 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 572418009821 iron binding site [ion binding]; other site 572418009823 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 572418009824 Fatty acid desaturase; Region: FA_desaturase; pfam00487 572418009825 Di-iron ligands [ion binding]; other site 572418009826 amino acid transporter; Region: 2A0306; TIGR00909 572418009827 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 572418009828 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 572418009829 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 572418009830 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 572418009831 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 572418009832 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 572418009833 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 572418009834 active site 572418009835 substrate binding site [chemical binding]; other site 572418009836 metal binding site [ion binding]; metal-binding site 572418009837 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 572418009838 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 572418009839 Transcription factor WhiB; Region: Whib; pfam02467 572418009840 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 572418009841 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 572418009842 phosphate binding site [ion binding]; other site 572418009843 dimer interface [polypeptide binding]; other site 572418009844 substrate binding site [chemical binding]; other site 572418009845 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 572418009846 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 572418009847 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 572418009848 putative FMN binding site [chemical binding]; other site 572418009849 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 572418009850 Methyltransferase domain; Region: Methyltransf_26; pfam13659 572418009852 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 572418009853 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 572418009854 active site 572418009855 Substrate binding site; other site 572418009856 Mg++ binding site; other site 572418009857 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 572418009858 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 572418009859 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 572418009860 Probable Catalytic site; other site 572418009861 metal-binding site 572418009862 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 572418009863 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 572418009864 NADP binding site [chemical binding]; other site 572418009865 active site 572418009866 putative substrate binding site [chemical binding]; other site 572418009867 Transcriptional regulator [Transcription]; Region: LytR; COG1316 572418009868 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 572418009870 TIGR03089 family protein; Region: TIGR03089 572418009871 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 572418009872 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572418009873 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418009874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 572418009875 active site 572418009876 motif I; other site 572418009877 motif II; other site 572418009879 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 572418009880 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 572418009881 CoA-transferase family III; Region: CoA_transf_3; pfam02515 572418009882 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 572418009883 Sulfate transporter family; Region: Sulfate_transp; pfam00916 572418009884 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 572418009885 active site clefts [active] 572418009886 zinc binding site [ion binding]; other site 572418009887 dimer interface [polypeptide binding]; other site 572418009889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418009890 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 572418009891 FAD binding site [chemical binding]; other site 572418009892 homotetramer interface [polypeptide binding]; other site 572418009893 substrate binding pocket [chemical binding]; other site 572418009894 catalytic base [active] 572418009897 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 572418009898 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 572418009899 ATP-grasp domain; Region: ATP-grasp; pfam02222 572418009900 Predicted membrane protein [Function unknown]; Region: COG2246 572418009901 GtrA-like protein; Region: GtrA; pfam04138 572418009903 Bacterial PH domain; Region: DUF304; pfam03703 572418009904 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 572418009905 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 572418009906 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 572418009907 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 572418009908 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 572418009909 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572418009911 Maf-like protein; Region: Maf; pfam02545 572418009912 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 572418009913 active site 572418009914 dimer interface [polypeptide binding]; other site 572418009915 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 572418009916 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 572418009917 active site residue [active] 572418009918 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 572418009919 active site residue [active] 572418009921 Fe-S metabolism associated domain; Region: SufE; pfam02657 572418009922 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 572418009923 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 572418009924 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 572418009925 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 572418009926 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 572418009927 carboxyltransferase (CT) interaction site; other site 572418009928 biotinylation site [posttranslational modification]; other site 572418009931 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 572418009932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418009933 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572418009934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 572418009935 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 572418009936 L-lysine aminotransferase; Provisional; Region: PRK08297 572418009937 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572418009938 inhibitor-cofactor binding pocket; inhibition site 572418009939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418009940 catalytic residue [active] 572418009941 putative DNA binding site [nucleotide binding]; other site 572418009942 dimerization interface [polypeptide binding]; other site 572418009943 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 572418009944 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 572418009945 putative Zn2+ binding site [ion binding]; other site 572418009946 AsnC family; Region: AsnC_trans_reg; pfam01037 572418009947 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 572418009948 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 572418009949 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 572418009950 tetrameric interface [polypeptide binding]; other site 572418009951 NAD binding site [chemical binding]; other site 572418009952 catalytic residues [active] 572418009955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418009956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418009957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418009958 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 572418009959 ATP binding site [chemical binding]; other site 572418009960 putative Mg++ binding site [ion binding]; other site 572418009961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418009962 nucleotide binding region [chemical binding]; other site 572418009963 ATP-binding site [chemical binding]; other site 572418009964 DEAD/H associated; Region: DEAD_assoc; pfam08494 572418009966 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 572418009967 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 572418009968 putative DNA binding site [nucleotide binding]; other site 572418009969 catalytic residue [active] 572418009970 putative H2TH interface [polypeptide binding]; other site 572418009971 putative catalytic residues [active] 572418009972 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 572418009973 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 572418009974 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 572418009975 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 572418009976 Sulfatase; Region: Sulfatase; pfam00884 572418009979 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 572418009980 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 572418009981 probable active site [active] 572418009982 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 572418009983 PhoU domain; Region: PhoU; pfam01895 572418009984 PhoU domain; Region: PhoU; pfam01895 572418009985 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 572418009988 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 572418009989 putative active site pocket [active] 572418009990 dimerization interface [polypeptide binding]; other site 572418009991 putative catalytic residue [active] 572418009992 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 572418009993 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 572418009994 metal binding site [ion binding]; metal-binding site 572418009995 putative dimer interface [polypeptide binding]; other site 572418009997 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 572418009998 amidohydrolase; Region: amidohydrolases; TIGR01891 572418009999 metal binding site [ion binding]; metal-binding site 572418010000 purine nucleoside phosphorylase; Provisional; Region: PRK08202 572418010001 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 572418010002 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 572418010003 active site 572418010004 substrate binding site [chemical binding]; other site 572418010005 metal binding site [ion binding]; metal-binding site 572418010007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418010008 active site 572418010009 Phosphoesterase family; Region: Phosphoesterase; pfam04185 572418010010 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418010011 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 572418010012 adenosine deaminase; Provisional; Region: PRK09358 572418010013 active site 572418010014 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 572418010015 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572418010016 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572418010017 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 572418010019 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 572418010020 active site 572418010021 catalytic motif [active] 572418010022 Zn binding site [ion binding]; other site 572418010024 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 572418010025 putative Iron-sulfur protein interface [polypeptide binding]; other site 572418010026 putative proximal heme binding site [chemical binding]; other site 572418010027 putative SdhD-like interface [polypeptide binding]; other site 572418010028 putative distal heme binding site [chemical binding]; other site 572418010029 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 572418010030 putative Iron-sulfur protein interface [polypeptide binding]; other site 572418010031 putative proximal heme binding site [chemical binding]; other site 572418010032 putative SdhC-like subunit interface [polypeptide binding]; other site 572418010033 putative distal heme binding site [chemical binding]; other site 572418010034 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 572418010035 L-aspartate oxidase; Provisional; Region: PRK06175 572418010036 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 572418010038 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 572418010039 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 572418010041 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418010042 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 572418010043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418010044 S-adenosylmethionine binding site [chemical binding]; other site 572418010045 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 572418010046 MoaE interaction surface [polypeptide binding]; other site 572418010047 thiocarboxylated glycine; other site 572418010048 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 572418010049 MoaE homodimer interface [polypeptide binding]; other site 572418010050 MoaD interaction [polypeptide binding]; other site 572418010051 active site residues [active] 572418010052 putative transposase OrfB; Reviewed; Region: PHA02517 572418010053 HTH-like domain; Region: HTH_21; pfam13276 572418010054 Integrase core domain; Region: rve; pfam00665 572418010055 Integrase core domain; Region: rve_3; pfam13683 572418010056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572418010057 Transposase; Region: HTH_Tnp_1; cl17663 572418010058 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 572418010059 trimer interface [polypeptide binding]; other site 572418010060 dimer interface [polypeptide binding]; other site 572418010061 putative active site [active] 572418010062 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 572418010063 aromatic arch; other site 572418010064 DCoH dimer interaction site [polypeptide binding]; other site 572418010065 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 572418010066 DCoH tetramer interaction site [polypeptide binding]; other site 572418010067 substrate binding site [chemical binding]; other site 572418010068 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 572418010069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 572418010070 FeS/SAM binding site; other site 572418010071 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 572418010072 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 572418010073 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 572418010074 DNA binding site [nucleotide binding] 572418010075 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418010076 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418010077 phosphopeptide binding site; other site 572418010078 Condensation domain; Region: Condensation; pfam00668 572418010079 Transposase; Region: DEDD_Tnp_IS110; pfam01548 572418010080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 572418010081 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 572418010082 Uncharacterized conserved protein [Function unknown]; Region: COG2128 572418010083 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 572418010084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418010085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418010086 DNA binding residues [nucleotide binding] 572418010087 SnoaL-like domain; Region: SnoaL_2; pfam12680 572418010088 hypothetical protein; Provisional; Region: PRK06541 572418010089 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 572418010090 inhibitor-cofactor binding pocket; inhibition site 572418010091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418010092 catalytic residue [active] 572418010093 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 572418010094 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 572418010095 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 572418010096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418010099 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 572418010100 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 572418010101 active site 572418010102 dimer interface [polypeptide binding]; other site 572418010103 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418010104 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 572418010105 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 572418010106 DNA binding residues [nucleotide binding] 572418010107 dimer interface [polypeptide binding]; other site 572418010108 metal binding site [ion binding]; metal-binding site 572418010109 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 572418010110 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 572418010111 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 572418010112 active site 572418010113 HIGH motif; other site 572418010114 dimer interface [polypeptide binding]; other site 572418010115 KMSKS motif; other site 572418010117 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418010118 isocitrate dehydrogenase; Validated; Region: PRK08299 572418010120 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 572418010121 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 572418010122 homodimer interface [polypeptide binding]; other site 572418010123 substrate-cofactor binding pocket; other site 572418010124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418010125 catalytic residue [active] 572418010127 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 572418010128 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 572418010129 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572418010130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418010131 S-adenosylmethionine binding site [chemical binding]; other site 572418010132 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010133 PPE family; Region: PPE; pfam00823 572418010134 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010135 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010136 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010137 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010138 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010139 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010140 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010141 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010142 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010143 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010144 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010145 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010146 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010147 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010148 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010149 PE family; Region: PE; pfam00934 572418010150 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 572418010152 Transposase; Region: DEDD_Tnp_IS110; pfam01548 572418010153 Transposase; Region: DDE_Tnp_ISL3; pfam01610 572418010155 Berberine and berberine like; Region: BBE; pfam08031 572418010156 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418010157 Protein of unknown function (DUF732); Region: DUF732; pfam05305 572418010158 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 572418010159 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 572418010160 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 572418010161 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 572418010162 homodimer interface [polypeptide binding]; other site 572418010163 NADP binding site [chemical binding]; other site 572418010164 substrate binding site [chemical binding]; other site 572418010165 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 572418010166 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 572418010167 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 572418010168 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 572418010169 active site 572418010170 FMN binding site [chemical binding]; other site 572418010171 substrate binding site [chemical binding]; other site 572418010172 putative catalytic residue [active] 572418010173 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572418010174 phosphate binding site [ion binding]; other site 572418010175 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418010176 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 572418010177 phosphopeptide binding site; other site 572418010178 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 572418010179 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572418010180 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 572418010181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 572418010182 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 572418010183 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 572418010184 G1 box; other site 572418010185 GTP/Mg2+ binding site [chemical binding]; other site 572418010186 G2 box; other site 572418010187 Switch I region; other site 572418010188 G3 box; other site 572418010189 Switch II region; other site 572418010190 G4 box; other site 572418010191 G5 box; other site 572418010193 Protein of unknown function (DUF742); Region: DUF742; pfam05331 572418010194 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 572418010195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572418010196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418010197 ATP binding site [chemical binding]; other site 572418010198 Mg2+ binding site [ion binding]; other site 572418010199 G-X-G motif; other site 572418010201 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 572418010202 PE family; Region: PE; pfam00934 572418010203 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 572418010204 FMN binding site [chemical binding]; other site 572418010205 dimer interface [polypeptide binding]; other site 572418010206 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 572418010207 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 572418010208 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 572418010209 active site 572418010210 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 572418010211 generic binding surface II; other site 572418010212 generic binding surface I; other site 572418010213 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418010214 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418010215 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 572418010216 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 572418010217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418010218 active site 572418010219 motif I; other site 572418010220 motif II; other site 572418010221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418010222 substrate binding site [chemical binding]; other site 572418010223 oxyanion hole (OAH) forming residues; other site 572418010224 trimer interface [polypeptide binding]; other site 572418010225 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 572418010226 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 572418010227 Amidase; Region: Amidase; pfam01425 572418010228 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 572418010229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418010230 motif II; other site 572418010231 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 572418010233 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 572418010234 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 572418010235 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572418010236 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572418010237 substrate binding pocket [chemical binding]; other site 572418010238 chain length determination region; other site 572418010239 substrate-Mg2+ binding site; other site 572418010240 catalytic residues [active] 572418010241 aspartate-rich region 1; other site 572418010242 active site lid residues [active] 572418010243 aspartate-rich region 2; other site 572418010245 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 572418010246 putative active site [active] 572418010247 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 572418010248 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 572418010249 Transposase domain (DUF772); Region: DUF772; pfam05598 572418010250 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 572418010251 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 572418010252 PE family; Region: PE; pfam00934 572418010253 enoyl-CoA hydratase; Region: PLN02864 572418010254 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 572418010255 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 572418010256 dimer interaction site [polypeptide binding]; other site 572418010257 substrate-binding tunnel; other site 572418010258 active site 572418010259 catalytic site [active] 572418010260 substrate binding site [chemical binding]; other site 572418010261 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418010263 short chain dehydrogenase; Provisional; Region: PRK07201 572418010264 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 572418010265 putative NAD(P) binding site [chemical binding]; other site 572418010266 active site 572418010267 putative substrate binding site [chemical binding]; other site 572418010268 classical (c) SDRs; Region: SDR_c; cd05233 572418010269 NAD(P) binding site [chemical binding]; other site 572418010270 active site 572418010271 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418010272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418010273 S-adenosylmethionine binding site [chemical binding]; other site 572418010274 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 572418010275 active site 572418010276 DNA Polymerase Y-family; Region: PolY_like; cd03468 572418010277 DNA binding site [nucleotide binding] 572418010278 GMP synthase; Reviewed; Region: guaA; PRK00074 572418010279 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 572418010280 AMP/PPi binding site [chemical binding]; other site 572418010281 candidate oxyanion hole; other site 572418010282 catalytic triad [active] 572418010283 potential glutamine specificity residues [chemical binding]; other site 572418010284 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 572418010285 ATP Binding subdomain [chemical binding]; other site 572418010286 Ligand Binding sites [chemical binding]; other site 572418010287 Dimerization subdomain; other site 572418010289 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 572418010290 active site lid residues [active] 572418010291 substrate binding pocket [chemical binding]; other site 572418010292 catalytic residues [active] 572418010293 substrate-Mg2+ binding site; other site 572418010294 aspartate-rich region 1; other site 572418010295 aspartate-rich region 2; other site 572418010297 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 572418010298 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 572418010299 substrate binding pocket [chemical binding]; other site 572418010300 chain length determination region; other site 572418010301 substrate-Mg2+ binding site; other site 572418010302 catalytic residues [active] 572418010303 aspartate-rich region 1; other site 572418010304 active site lid residues [active] 572418010305 aspartate-rich region 2; other site 572418010307 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418010308 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418010309 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 572418010310 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 572418010311 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 572418010312 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 572418010313 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 572418010314 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 572418010316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 572418010317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418010318 hypothetical protein; Provisional; Region: PRK07579 572418010319 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 572418010320 active site 572418010321 cosubstrate binding site; other site 572418010322 substrate binding site [chemical binding]; other site 572418010323 catalytic site [active] 572418010324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418010325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418010326 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 572418010327 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 572418010328 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 572418010329 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 572418010330 putative active site [active] 572418010331 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 572418010332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418010333 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 572418010335 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 572418010336 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572418010337 phosphate binding site [ion binding]; other site 572418010338 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 572418010339 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 572418010340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 572418010341 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 572418010342 active site 572418010344 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 572418010345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572418010346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 572418010347 DNA binding residues [nucleotide binding] 572418010348 Transcription factor WhiB; Region: Whib; pfam02467 572418010349 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 572418010350 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 572418010351 ring oligomerisation interface [polypeptide binding]; other site 572418010352 ATP/Mg binding site [chemical binding]; other site 572418010353 stacking interactions; other site 572418010354 hinge regions; other site 572418010357 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 572418010358 oligomerisation interface [polypeptide binding]; other site 572418010359 mobile loop; other site 572418010360 roof hairpin; other site 572418010362 UGMP family protein; Validated; Region: PRK09604 572418010364 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 572418010365 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 572418010366 Coenzyme A binding pocket [chemical binding]; other site 572418010367 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 572418010368 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 572418010370 alanine racemase; Reviewed; Region: alr; PRK00053 572418010371 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 572418010372 active site 572418010373 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 572418010374 dimer interface [polypeptide binding]; other site 572418010375 substrate binding site [chemical binding]; other site 572418010376 catalytic residues [active] 572418010377 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010378 PPE family; Region: PPE; pfam00823 572418010380 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 572418010381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418010382 Walker A motif; other site 572418010383 ATP binding site [chemical binding]; other site 572418010384 Walker B motif; other site 572418010385 arginine finger; other site 572418010387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 572418010388 Integrase core domain; Region: rve; pfam00665 572418010389 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418010390 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010391 PPE family; Region: PPE; pfam00823 572418010392 Integrase core domain; Region: rve; pfam00665 572418010393 Integrase core domain; Region: rve_3; pfam13683 572418010394 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418010395 MULE transposase domain; Region: MULE; pfam10551 572418010396 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 572418010397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418010398 catalytic residue [active] 572418010399 Uncharacterized conserved protein [Function unknown]; Region: COG0062 572418010400 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 572418010401 putative substrate binding site [chemical binding]; other site 572418010402 putative ATP binding site [chemical binding]; other site 572418010405 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 572418010406 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 572418010407 glutaminase active site [active] 572418010408 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 572418010409 dimer interface [polypeptide binding]; other site 572418010410 active site 572418010411 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 572418010412 dimer interface [polypeptide binding]; other site 572418010413 active site 572418010414 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 572418010415 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 572418010416 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 572418010417 active site 572418010418 substrate binding site [chemical binding]; other site 572418010419 metal binding site [ion binding]; metal-binding site 572418010421 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 572418010423 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 572418010424 23S rRNA interface [nucleotide binding]; other site 572418010425 L3 interface [polypeptide binding]; other site 572418010426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 572418010427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 572418010428 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 572418010429 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 572418010430 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418010431 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 572418010432 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418010433 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418010437 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 572418010439 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 572418010440 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 572418010441 active site 572418010442 catalytic residues [active] 572418010446 Protein of unknown function (DUF690); Region: DUF690; pfam05108 572418010448 Cutinase; Region: Cutinase; pfam01083 572418010449 Cutinase; Region: Cutinase; pfam01083 572418010450 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 572418010452 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 572418010453 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 572418010454 active site 572418010455 dimerization interface 3.5A [polypeptide binding]; other site 572418010456 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 572418010457 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 572418010458 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 572418010459 alphaNTD - beta interaction site [polypeptide binding]; other site 572418010460 alphaNTD homodimer interface [polypeptide binding]; other site 572418010461 alphaNTD - beta' interaction site [polypeptide binding]; other site 572418010462 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 572418010464 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 572418010465 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 572418010466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572418010467 RNA binding surface [nucleotide binding]; other site 572418010470 30S ribosomal protein S11; Validated; Region: PRK05309 572418010472 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 572418010473 30S ribosomal protein S13; Region: bact_S13; TIGR03631 572418010475 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 572418010477 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 572418010478 rRNA binding site [nucleotide binding]; other site 572418010479 predicted 30S ribosome binding site; other site 572418010480 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 572418010481 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 572418010482 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 572418010483 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 572418010484 NAD binding site [chemical binding]; other site 572418010485 substrate binding site [chemical binding]; other site 572418010486 homodimer interface [polypeptide binding]; other site 572418010487 active site 572418010488 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 572418010489 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418010490 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418010491 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418010492 active site 572418010493 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572418010494 extended (e) SDRs; Region: SDR_e; cd08946 572418010495 NAD(P) binding site [chemical binding]; other site 572418010496 active site 572418010497 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 572418010498 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 572418010499 active site 572418010500 catalytic residues [active] 572418010501 metal binding site [ion binding]; metal-binding site 572418010502 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 572418010503 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572418010504 PYR/PP interface [polypeptide binding]; other site 572418010505 dimer interface [polypeptide binding]; other site 572418010506 TPP binding site [chemical binding]; other site 572418010507 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 572418010508 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 572418010509 TPP-binding site [chemical binding]; other site 572418010511 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 572418010512 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 572418010513 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418010514 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 572418010515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418010516 metabolite-proton symporter; Region: 2A0106; TIGR00883 572418010517 putative substrate translocation pore; other site 572418010520 PE family; Region: PE; pfam00934 572418010521 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010522 PPE family; Region: PPE; pfam00823 572418010523 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418010524 patatin-related protein; Region: TIGR03607 572418010525 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418010526 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418010527 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 572418010528 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 572418010529 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 572418010530 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 572418010531 Transcriptional regulator [Transcription]; Region: LytR; COG1316 572418010532 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 572418010533 short chain dehydrogenase; Provisional; Region: PRK05875 572418010534 classical (c) SDRs; Region: SDR_c; cd05233 572418010535 NAD(P) binding site [chemical binding]; other site 572418010536 active site 572418010538 Predicted membrane protein [Function unknown]; Region: COG2259 572418010539 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 572418010540 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 572418010541 Predicted transcriptional regulators [Transcription]; Region: COG1695 572418010542 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 572418010543 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 572418010544 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 572418010545 active site 572418010546 homotetramer interface [polypeptide binding]; other site 572418010548 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418010549 mce related protein; Region: MCE; pfam02470 572418010550 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418010551 mce related protein; Region: MCE; pfam02470 572418010553 mce related protein; Region: MCE; pfam02470 572418010554 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418010555 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 572418010556 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418010557 mce related protein; Region: MCE; pfam02470 572418010558 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418010559 mce related protein; Region: MCE; pfam02470 572418010560 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 572418010561 mce related protein; Region: MCE; pfam02470 572418010562 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 572418010563 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 572418010564 Permease; Region: Permease; pfam02405 572418010565 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 572418010566 Permease; Region: Permease; pfam02405 572418010567 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 572418010568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418010569 NAD(P) binding site [chemical binding]; other site 572418010570 active site 572418010572 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 572418010573 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 572418010574 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010575 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 572418010576 FAD binding site [chemical binding]; other site 572418010577 substrate binding site [chemical binding]; other site 572418010578 catalytic base [active] 572418010579 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010580 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010581 active site 572418010582 acyl-CoA synthetase; Validated; Region: PRK07867 572418010583 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 572418010584 acyl-activating enzyme (AAE) consensus motif; other site 572418010585 putative AMP binding site [chemical binding]; other site 572418010586 putative active site [active] 572418010587 putative CoA binding site [chemical binding]; other site 572418010589 PE family; Region: PE; pfam00934 572418010594 hypothetical protein; Validated; Region: PRK07586 572418010595 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 572418010596 PYR/PP interface [polypeptide binding]; other site 572418010597 dimer interface [polypeptide binding]; other site 572418010598 TPP binding site [chemical binding]; other site 572418010599 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 572418010600 TPP-binding site [chemical binding]; other site 572418010601 dimer interface [polypeptide binding]; other site 572418010602 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 572418010603 PE family; Region: PE; pfam00934 572418010605 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418010606 CoA binding site [chemical binding]; other site 572418010608 acyl-CoA synthetase; Validated; Region: PRK07798 572418010609 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418010610 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 572418010611 acyl-activating enzyme (AAE) consensus motif; other site 572418010612 acyl-activating enzyme (AAE) consensus motif; other site 572418010613 putative AMP binding site [chemical binding]; other site 572418010614 putative active site [active] 572418010615 putative CoA binding site [chemical binding]; other site 572418010617 enoyl-CoA hydratase; Provisional; Region: PRK07799 572418010618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418010619 substrate binding site [chemical binding]; other site 572418010620 oxyanion hole (OAH) forming residues; other site 572418010621 trimer interface [polypeptide binding]; other site 572418010622 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 572418010625 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 572418010626 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 572418010627 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 572418010628 DUF35 OB-fold domain; Region: DUF35; pfam01796 572418010629 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 572418010630 DUF35 OB-fold domain; Region: DUF35; pfam01796 572418010631 lipid-transfer protein; Provisional; Region: PRK07937 572418010632 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 572418010633 active site 572418010635 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 572418010636 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 572418010637 active site 572418010638 NHL repeat; Region: NHL; pfam01436 572418010639 Uncharacterized conserved protein [Function unknown]; Region: COG3391 572418010640 NHL repeat; Region: NHL; pfam01436 572418010641 NHL repeat; Region: NHL; pfam01436 572418010642 NHL repeat; Region: NHL; pfam01436 572418010643 NHL repeat; Region: NHL; pfam01436 572418010645 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 572418010646 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 572418010647 trimer interface [polypeptide binding]; other site 572418010648 putative metal binding site [ion binding]; other site 572418010649 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 572418010650 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 572418010652 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 572418010653 short chain dehydrogenase; Provisional; Region: PRK07890 572418010654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418010655 NAD(P) binding site [chemical binding]; other site 572418010656 active site 572418010657 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010658 PPE family; Region: PPE; pfam00823 572418010659 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 572418010660 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010661 PPE family; Region: PPE; pfam00823 572418010662 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010663 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 572418010664 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 572418010665 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 572418010666 active site 572418010667 catalytic residues [active] 572418010668 metal binding site [ion binding]; metal-binding site 572418010669 DmpG-like communication domain; Region: DmpG_comm; pfam07836 572418010670 acetaldehyde dehydrogenase; Validated; Region: PRK08300 572418010671 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572418010672 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 572418010673 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 572418010674 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 572418010675 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 572418010676 enoyl-CoA hydratase; Region: PLN02864 572418010677 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 572418010678 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 572418010679 dimer interaction site [polypeptide binding]; other site 572418010680 substrate-binding tunnel; other site 572418010681 active site 572418010682 catalytic site [active] 572418010683 substrate binding site [chemical binding]; other site 572418010684 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010685 PPE family; Region: PPE; pfam00823 572418010686 PE-PPE domain; Region: PE-PPE; pfam08237 572418010687 lipid-transfer protein; Provisional; Region: PRK07855 572418010688 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 572418010689 active site 572418010690 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 572418010691 putative active site [active] 572418010692 putative catalytic site [active] 572418010694 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 572418010695 active site 572418010696 catalytic site [active] 572418010697 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 572418010698 DUF35 OB-fold domain; Region: DUF35; pfam01796 572418010699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010701 active site 572418010702 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010703 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 572418010704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010705 active site 572418010706 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418010707 Cytochrome P450; Region: p450; cl12078 572418010708 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 572418010709 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572418010710 dimer interface [polypeptide binding]; other site 572418010711 active site 572418010713 Domain of unknown function (DUF385); Region: DUF385; pfam04075 572418010714 short chain dehydrogenase; Provisional; Region: PRK07791 572418010715 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 572418010716 homodimer interface [polypeptide binding]; other site 572418010717 NAD binding site [chemical binding]; other site 572418010718 active site 572418010720 short chain dehydrogenase; Provisional; Region: PRK07856 572418010721 classical (c) SDRs; Region: SDR_c; cd05233 572418010722 NAD(P) binding site [chemical binding]; other site 572418010723 active site 572418010725 enoyl-CoA hydratase; Provisional; Region: PRK06495 572418010726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418010727 substrate binding site [chemical binding]; other site 572418010728 oxyanion hole (OAH) forming residues; other site 572418010729 trimer interface [polypeptide binding]; other site 572418010730 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 572418010731 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 572418010732 Nitronate monooxygenase; Region: NMO; pfam03060 572418010733 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 572418010734 FMN binding site [chemical binding]; other site 572418010735 substrate binding site [chemical binding]; other site 572418010736 putative catalytic residue [active] 572418010737 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 572418010738 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 572418010739 putative di-iron ligands [ion binding]; other site 572418010740 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 572418010741 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 572418010742 FAD binding pocket [chemical binding]; other site 572418010743 FAD binding motif [chemical binding]; other site 572418010744 phosphate binding motif [ion binding]; other site 572418010745 beta-alpha-beta structure motif; other site 572418010746 NAD(p) ribose binding residues [chemical binding]; other site 572418010747 NAD binding pocket [chemical binding]; other site 572418010748 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 572418010749 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572418010750 catalytic loop [active] 572418010751 iron binding site [ion binding]; other site 572418010753 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 572418010754 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 572418010755 putative active site [active] 572418010756 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 572418010757 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 572418010758 dimer interface [polypeptide binding]; other site 572418010759 active site 572418010761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418010762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418010763 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418010764 PPE family; Region: PPE; pfam00823 572418010765 short chain dehydrogenase; Provisional; Region: PRK07831 572418010766 classical (c) SDRs; Region: SDR_c; cd05233 572418010767 NAD(P) binding site [chemical binding]; other site 572418010768 active site 572418010769 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010771 active site 572418010772 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 572418010773 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 572418010774 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 572418010775 acyl-activating enzyme (AAE) consensus motif; other site 572418010776 putative AMP binding site [chemical binding]; other site 572418010777 putative active site [active] 572418010778 putative CoA binding site [chemical binding]; other site 572418010780 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010781 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010782 active site 572418010783 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010784 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 572418010785 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010786 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010787 active site 572418010788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010789 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 572418010790 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010791 active site 572418010792 aspartate aminotransferase; Provisional; Region: PRK05764 572418010793 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418010794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418010795 homodimer interface [polypeptide binding]; other site 572418010796 catalytic residue [active] 572418010798 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 572418010799 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 572418010800 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 572418010801 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 572418010802 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 572418010803 active site 572418010804 Fe binding site [ion binding]; other site 572418010806 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 572418010808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010809 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 572418010810 Flavin binding site [chemical binding]; other site 572418010811 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 572418010812 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 572418010813 FAD binding pocket [chemical binding]; other site 572418010814 FAD binding motif [chemical binding]; other site 572418010815 phosphate binding motif [ion binding]; other site 572418010816 beta-alpha-beta structure motif; other site 572418010817 NAD(p) ribose binding residues [chemical binding]; other site 572418010818 NAD binding pocket [chemical binding]; other site 572418010819 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 572418010820 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 572418010821 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 572418010822 catalytic loop [active] 572418010823 iron binding site [ion binding]; other site 572418010825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010827 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 572418010828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418010829 active site 572418010831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418010832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418010833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 572418010834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 572418010835 DNA binding site [nucleotide binding] 572418010836 domain linker motif; other site 572418010837 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 572418010838 putative dimerization interface [polypeptide binding]; other site 572418010839 putative ligand binding site [chemical binding]; other site 572418010840 PknH-like extracellular domain; Region: PknH_C; pfam14032 572418010842 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 572418010843 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 572418010844 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 572418010845 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 572418010846 transmembrane helices; other site 572418010847 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 572418010848 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 572418010849 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 572418010850 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 572418010851 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 572418010852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572418010853 active site 572418010854 HIGH motif; other site 572418010855 nucleotide binding site [chemical binding]; other site 572418010856 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 572418010857 KMSKS motif; other site 572418010858 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 572418010859 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 572418010860 homotrimer interaction site [polypeptide binding]; other site 572418010861 zinc binding site [ion binding]; other site 572418010862 CDP-binding sites; other site 572418010863 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 572418010864 substrate binding site; other site 572418010865 dimer interface; other site 572418010866 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 572418010868 DNA repair protein RadA; Provisional; Region: PRK11823 572418010869 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 572418010870 Walker A motif/ATP binding site; other site 572418010871 ATP binding site [chemical binding]; other site 572418010872 Walker B motif; other site 572418010873 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 572418010875 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 572418010876 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 572418010877 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 572418010878 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 572418010879 active site clefts [active] 572418010880 zinc binding site [ion binding]; other site 572418010881 dimer interface [polypeptide binding]; other site 572418010884 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572418010885 endonuclease III; Region: ENDO3c; smart00478 572418010886 minor groove reading motif; other site 572418010887 helix-hairpin-helix signature motif; other site 572418010888 substrate binding pocket [chemical binding]; other site 572418010889 active site 572418010890 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 572418010891 PE family; Region: PE; pfam00934 572418010892 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418010893 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 572418010894 catalytic site [active] 572418010895 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 572418010896 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 572418010897 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 572418010899 Ami_2 domain; Region: Ami_2; smart00644 572418010900 amidase catalytic site [active] 572418010901 Zn binding residues [ion binding]; other site 572418010902 substrate binding site [chemical binding]; other site 572418010903 PE family; Region: PE; pfam00934 572418010904 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 572418010905 Clp amino terminal domain; Region: Clp_N; pfam02861 572418010906 Clp amino terminal domain; Region: Clp_N; pfam02861 572418010907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418010908 Walker A motif; other site 572418010909 ATP binding site [chemical binding]; other site 572418010910 Walker B motif; other site 572418010911 arginine finger; other site 572418010912 UvrB/uvrC motif; Region: UVR; pfam02151 572418010913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418010914 Walker A motif; other site 572418010915 ATP binding site [chemical binding]; other site 572418010916 Walker B motif; other site 572418010917 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 572418010920 Lsr2; Region: Lsr2; pfam11774 572418010921 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 572418010922 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 572418010923 dimer interface [polypeptide binding]; other site 572418010924 putative anticodon binding site; other site 572418010925 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572418010926 motif 1; other site 572418010927 dimer interface [polypeptide binding]; other site 572418010928 active site 572418010929 motif 2; other site 572418010930 motif 3; other site 572418010932 pantothenate kinase; Reviewed; Region: PRK13318 572418010933 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 572418010934 tetramerization interface [polypeptide binding]; other site 572418010935 active site 572418010936 Pantoate-beta-alanine ligase; Region: PanC; cd00560 572418010937 pantoate--beta-alanine ligase; Region: panC; TIGR00018 572418010938 active site 572418010939 ATP-binding site [chemical binding]; other site 572418010940 pantoate-binding site; other site 572418010941 HXXH motif; other site 572418010942 Rossmann-like domain; Region: Rossmann-like; pfam10727 572418010943 Uncharacterized conserved protein [Function unknown]; Region: COG5495 572418010944 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 572418010945 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 572418010946 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 572418010947 catalytic center binding site [active] 572418010948 ATP binding site [chemical binding]; other site 572418010949 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 572418010950 homooctamer interface [polypeptide binding]; other site 572418010951 active site 572418010952 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 572418010953 dihydropteroate synthase; Region: DHPS; TIGR01496 572418010954 substrate binding pocket [chemical binding]; other site 572418010955 dimer interface [polypeptide binding]; other site 572418010956 inhibitor binding site; inhibition site 572418010959 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 572418010960 homodecamer interface [polypeptide binding]; other site 572418010961 GTP cyclohydrolase I; Provisional; Region: PLN03044 572418010962 active site 572418010963 putative catalytic site residues [active] 572418010964 zinc binding site [ion binding]; other site 572418010965 GTP-CH-I/GFRP interaction surface; other site 572418010967 FtsH Extracellular; Region: FtsH_ext; pfam06480 572418010968 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 572418010969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418010970 Walker A motif; other site 572418010971 ATP binding site [chemical binding]; other site 572418010972 Walker B motif; other site 572418010973 arginine finger; other site 572418010974 Peptidase family M41; Region: Peptidase_M41; pfam01434 572418010977 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 572418010978 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 572418010981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 572418010982 active site 572418010984 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 572418010985 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 572418010986 Ligand Binding Site [chemical binding]; other site 572418010987 Uncharacterized conserved protein [Function unknown]; Region: COG5282 572418010988 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 572418010990 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 572418010991 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 572418010992 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 572418010993 dimer interface [polypeptide binding]; other site 572418010994 substrate binding site [chemical binding]; other site 572418010995 metal binding sites [ion binding]; metal-binding site 572418010996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 572418010998 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 572418010999 Ligand binding site; other site 572418011000 Putative Catalytic site; other site 572418011001 DXD motif; other site 572418011002 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 572418011003 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 572418011004 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572418011005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418011006 NAD(P) binding site [chemical binding]; other site 572418011007 active site 572418011008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 572418011009 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 572418011010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 572418011011 transposase; Provisional; Region: PRK06526 572418011012 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 572418011013 Walker B motif; other site 572418011014 Transposase, Mutator family; Region: Transposase_mut; pfam00872 572418011015 MULE transposase domain; Region: MULE; pfam10551 572418011016 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 572418011017 Fic/DOC family; Region: Fic; cl00960 572418011018 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 572418011019 DNA polymerase III subunit delta'; Validated; Region: PRK07940 572418011020 DNA polymerase III subunit delta'; Validated; Region: PRK08485 572418011021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 572418011022 dimerization interface [polypeptide binding]; other site 572418011023 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 572418011024 cyclase homology domain; Region: CHD; cd07302 572418011025 nucleotidyl binding site; other site 572418011026 metal binding site [ion binding]; metal-binding site 572418011027 dimer interface [polypeptide binding]; other site 572418011028 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 572418011029 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 572418011030 active site 572418011031 interdomain interaction site; other site 572418011032 putative metal-binding site [ion binding]; other site 572418011033 nucleotide binding site [chemical binding]; other site 572418011034 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 572418011035 domain I; other site 572418011036 phosphate binding site [ion binding]; other site 572418011037 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 572418011038 domain II; other site 572418011039 domain III; other site 572418011040 nucleotide binding site [chemical binding]; other site 572418011041 DNA binding groove [nucleotide binding] 572418011042 catalytic site [active] 572418011043 domain IV; other site 572418011044 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 572418011045 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 572418011046 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 572418011048 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 572418011049 DNA-binding site [nucleotide binding]; DNA binding site 572418011050 RNA-binding motif; other site 572418011052 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 572418011053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572418011054 ATP binding site [chemical binding]; other site 572418011055 putative Mg++ binding site [ion binding]; other site 572418011056 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572418011057 nucleotide binding region [chemical binding]; other site 572418011058 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 572418011059 PE family; Region: PE; pfam00934 572418011061 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 572418011062 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 572418011063 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 572418011064 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 572418011065 Walker A motif; other site 572418011066 hexamer interface [polypeptide binding]; other site 572418011067 ATP binding site [chemical binding]; other site 572418011068 Walker B motif; other site 572418011070 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 572418011071 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 572418011072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418011073 motif II; other site 572418011074 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 572418011075 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572418011076 Walker A/P-loop; other site 572418011077 ATP binding site [chemical binding]; other site 572418011078 Q-loop/lid; other site 572418011079 ABC transporter signature motif; other site 572418011080 Walker B; other site 572418011081 D-loop; other site 572418011082 H-loop/switch region; other site 572418011083 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 572418011084 Walker A/P-loop; other site 572418011085 ATP binding site [chemical binding]; other site 572418011086 Q-loop/lid; other site 572418011087 ABC transporter signature motif; other site 572418011088 Walker B; other site 572418011089 D-loop; other site 572418011090 H-loop/switch region; other site 572418011091 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572418011096 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 572418011097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418011098 ABC-ATPase subunit interface; other site 572418011099 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 572418011100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418011101 dimer interface [polypeptide binding]; other site 572418011102 conserved gate region; other site 572418011103 ABC-ATPase subunit interface; other site 572418011104 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 572418011105 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 572418011106 acetyl-CoA synthetase; Provisional; Region: PRK00174 572418011107 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 572418011108 active site 572418011109 CoA binding site [chemical binding]; other site 572418011110 acyl-activating enzyme (AAE) consensus motif; other site 572418011111 AMP binding site [chemical binding]; other site 572418011112 acetate binding site [chemical binding]; other site 572418011114 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 572418011115 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572418011117 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 572418011119 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 572418011120 putative active site [active] 572418011121 putative CoA binding site [chemical binding]; other site 572418011122 nudix motif; other site 572418011123 metal binding site [ion binding]; metal-binding site 572418011125 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 572418011126 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572418011127 catalytic residues [active] 572418011129 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 572418011130 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 572418011131 minor groove reading motif; other site 572418011132 helix-hairpin-helix signature motif; other site 572418011133 substrate binding pocket [chemical binding]; other site 572418011134 active site 572418011135 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 572418011138 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418011139 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418011140 ligand binding site [chemical binding]; other site 572418011141 flexible hinge region; other site 572418011142 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 572418011143 putative switch regulator; other site 572418011144 non-specific DNA interactions [nucleotide binding]; other site 572418011145 DNA binding site [nucleotide binding] 572418011146 sequence specific DNA binding site [nucleotide binding]; other site 572418011147 putative cAMP binding site [chemical binding]; other site 572418011148 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572418011149 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 572418011150 homotrimer interaction site [polypeptide binding]; other site 572418011151 putative active site [active] 572418011153 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 572418011154 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 572418011155 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 572418011156 P loop; other site 572418011157 Nucleotide binding site [chemical binding]; other site 572418011158 DTAP/Switch II; other site 572418011160 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 572418011161 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 572418011162 DTAP/Switch II; other site 572418011163 Switch I; other site 572418011164 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 572418011166 Transcription factor WhiB; Region: Whib; pfam02467 572418011167 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 572418011168 Transglycosylase; Region: Transgly; pfam00912 572418011169 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 572418011170 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 572418011171 phosphodiesterase YaeI; Provisional; Region: PRK11340 572418011172 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 572418011173 putative active site [active] 572418011174 putative metal binding site [ion binding]; other site 572418011175 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 572418011176 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 572418011177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418011178 catalytic residue [active] 572418011179 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 572418011180 Cytochrome P450; Region: p450; cl12078 572418011181 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 572418011182 anti sigma factor interaction site; other site 572418011183 regulatory phosphorylation site [posttranslational modification]; other site 572418011184 Uncharacterized conserved protein [Function unknown]; Region: COG1610 572418011185 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 572418011186 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 572418011187 MoxR-like ATPases [General function prediction only]; Region: COG0714 572418011188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418011189 Walker A motif; other site 572418011190 ATP binding site [chemical binding]; other site 572418011191 Walker B motif; other site 572418011192 arginine finger; other site 572418011193 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 572418011194 Protein of unknown function DUF58; Region: DUF58; pfam01882 572418011195 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 572418011196 Predicted membrane protein/domain [Function unknown]; Region: COG1714 572418011201 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 572418011202 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 572418011203 Methyltransferase domain; Region: Methyltransf_23; pfam13489 572418011204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418011205 S-adenosylmethionine binding site [chemical binding]; other site 572418011206 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572418011207 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 572418011208 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418011209 catalytic residue [active] 572418011211 Uncharacterized conserved protein [Function unknown]; Region: COG4301 572418011212 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 572418011213 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 572418011214 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 572418011215 putative active site [active] 572418011216 putative dimer interface [polypeptide binding]; other site 572418011217 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 572418011218 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 572418011219 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 572418011220 PknH-like extracellular domain; Region: PknH_C; pfam14032 572418011221 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 572418011222 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 572418011223 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 572418011225 aspartate kinase; Reviewed; Region: PRK06635 572418011226 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 572418011227 putative nucleotide binding site [chemical binding]; other site 572418011228 putative catalytic residues [active] 572418011229 putative Mg ion binding site [ion binding]; other site 572418011230 putative aspartate binding site [chemical binding]; other site 572418011231 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 572418011232 putative allosteric regulatory site; other site 572418011233 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 572418011234 putative allosteric regulatory residue; other site 572418011236 2-isopropylmalate synthase; Validated; Region: PRK03739 572418011237 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 572418011238 active site 572418011239 catalytic residues [active] 572418011240 metal binding site [ion binding]; metal-binding site 572418011241 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 572418011244 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 572418011245 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 572418011246 active site 572418011247 catalytic site [active] 572418011248 substrate binding site [chemical binding]; other site 572418011249 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 572418011250 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 572418011251 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 572418011252 catalytic triad [active] 572418011253 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 572418011254 putative active site [active] 572418011255 recombination protein RecR; Reviewed; Region: recR; PRK00076 572418011256 RecR protein; Region: RecR; pfam02132 572418011257 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 572418011258 putative active site [active] 572418011259 putative metal-binding site [ion binding]; other site 572418011260 tetramer interface [polypeptide binding]; other site 572418011261 hypothetical protein; Validated; Region: PRK00153 572418011262 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572418011263 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572418011264 active site 572418011265 metal binding site [ion binding]; metal-binding site 572418011266 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 572418011267 hydrophobic ligand binding site; other site 572418011268 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418011269 FAD binding domain; Region: FAD_binding_4; pfam01565 572418011270 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 572418011271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418011272 S-adenosylmethionine binding site [chemical binding]; other site 572418011273 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 572418011274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418011275 Walker A motif; other site 572418011276 ATP binding site [chemical binding]; other site 572418011277 Walker B motif; other site 572418011278 arginine finger; other site 572418011279 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 572418011281 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 572418011282 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572418011283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418011284 catalytic residue [active] 572418011285 Cutinase; Region: Cutinase; pfam01083 572418011286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418011287 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 572418011288 NAD(P) binding site [chemical binding]; other site 572418011289 active site 572418011290 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 572418011291 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 572418011292 putative NAD(P) binding site [chemical binding]; other site 572418011293 catalytic Zn binding site [ion binding]; other site 572418011294 Uncharacterized conserved protein [Function unknown]; Region: COG3349 572418011295 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 572418011296 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 572418011297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572418011298 putative substrate translocation pore; other site 572418011299 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 572418011300 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 572418011301 ligand binding site [chemical binding]; other site 572418011302 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 572418011303 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 572418011304 active site 572418011305 nucleophile elbow; other site 572418011309 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 572418011310 nucleotide binding site [chemical binding]; other site 572418011311 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 572418011312 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 572418011313 active site 572418011314 DNA binding site [nucleotide binding] 572418011315 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 572418011316 DNA binding site [nucleotide binding] 572418011317 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 572418011318 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 572418011319 nudix motif; other site 572418011320 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418011321 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418011323 Uncharacterized conserved protein [Function unknown]; Region: COG1839 572418011325 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 572418011326 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572418011327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572418011328 Uncharacterized conserved protein [Function unknown]; Region: COG2966 572418011329 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 572418011330 Uncharacterized conserved protein [Function unknown]; Region: COG3610 572418011331 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418011332 PPE family; Region: PPE; pfam00823 572418011333 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418011334 PPE family; Region: PPE; pfam00823 572418011335 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 572418011336 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 572418011337 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418011338 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418011339 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 572418011340 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 572418011341 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572418011342 Soluble P-type ATPase [General function prediction only]; Region: COG4087 572418011345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 572418011346 dimerization interface [polypeptide binding]; other site 572418011347 putative DNA binding site [nucleotide binding]; other site 572418011348 putative Zn2+ binding site [ion binding]; other site 572418011349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 572418011352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 572418011353 Transposase; Region: HTH_Tnp_1; cl17663 572418011354 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 572418011355 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572418011356 active site 572418011357 Int/Topo IB signature motif; other site 572418011358 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 572418011359 nucleoside/Zn binding site; other site 572418011360 dimer interface [polypeptide binding]; other site 572418011361 catalytic motif [active] 572418011363 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 572418011364 prephenate dehydrogenase; Validated; Region: PRK06545 572418011365 prephenate dehydrogenase; Validated; Region: PRK08507 572418011366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 572418011367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 572418011368 ABC-ATPase subunit interface; other site 572418011369 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 572418011370 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 572418011371 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 572418011372 Walker A/P-loop; other site 572418011373 ATP binding site [chemical binding]; other site 572418011374 Q-loop/lid; other site 572418011375 ABC transporter signature motif; other site 572418011376 Walker B; other site 572418011377 D-loop; other site 572418011378 H-loop/switch region; other site 572418011381 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 572418011382 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 572418011383 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 572418011384 putative active site [active] 572418011385 putative substrate binding site [chemical binding]; other site 572418011386 ATP binding site [chemical binding]; other site 572418011388 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 572418011389 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 572418011390 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 572418011392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 572418011393 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 572418011394 dimerization interface [polypeptide binding]; other site 572418011395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 572418011396 dimer interface [polypeptide binding]; other site 572418011397 phosphorylation site [posttranslational modification] 572418011398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572418011399 ATP binding site [chemical binding]; other site 572418011400 Mg2+ binding site [ion binding]; other site 572418011401 G-X-G motif; other site 572418011402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 572418011403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 572418011404 active site 572418011405 phosphorylation site [posttranslational modification] 572418011406 intermolecular recognition site; other site 572418011407 dimerization interface [polypeptide binding]; other site 572418011408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 572418011409 DNA binding site [nucleotide binding] 572418011410 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 572418011411 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418011412 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418011413 SnoaL-like domain; Region: SnoaL_2; pfam12680 572418011414 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 572418011415 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 572418011416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 572418011417 homodimer interface [polypeptide binding]; other site 572418011418 catalytic residue [active] 572418011420 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 572418011421 TIGR03086 family protein; Region: TIGR03086 572418011422 enoyl-CoA hydratase; Provisional; Region: PRK06142 572418011423 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 572418011424 substrate binding site [chemical binding]; other site 572418011425 oxyanion hole (OAH) forming residues; other site 572418011426 trimer interface [polypeptide binding]; other site 572418011427 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 572418011428 Beta-lactamase; Region: Beta-lactamase; pfam00144 572418011429 Domain of unknown function (DUF222); Region: DUF222; pfam02720 572418011430 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 572418011431 active site 572418011432 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 572418011433 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 572418011434 NAD(P) binding site [chemical binding]; other site 572418011435 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 572418011436 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 572418011437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 572418011438 catalytic residue [active] 572418011439 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 572418011440 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 572418011441 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 572418011442 Walker A/P-loop; other site 572418011443 ATP binding site [chemical binding]; other site 572418011444 Q-loop/lid; other site 572418011445 ABC transporter signature motif; other site 572418011446 Walker B; other site 572418011447 D-loop; other site 572418011448 H-loop/switch region; other site 572418011450 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 572418011451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572418011452 active site 572418011453 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 572418011454 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 572418011455 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 572418011456 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 572418011457 NAD binding site [chemical binding]; other site 572418011458 substrate binding site [chemical binding]; other site 572418011459 active site 572418011460 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572418011461 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572418011462 active site 572418011463 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 572418011464 Peptidase family M23; Region: Peptidase_M23; pfam01551 572418011465 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 572418011466 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 572418011467 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 572418011468 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 572418011469 Predicted membrane protein [Function unknown]; Region: COG2246 572418011470 GtrA-like protein; Region: GtrA; pfam04138 572418011471 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 572418011472 FAD binding domain; Region: FAD_binding_4; pfam01565 572418011473 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 572418011474 short chain dehydrogenase; Provisional; Region: PRK07904 572418011475 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 572418011476 NAD(P) binding site [chemical binding]; other site 572418011477 active site 572418011479 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 572418011480 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 572418011481 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 572418011484 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 572418011485 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 572418011486 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 572418011487 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 572418011488 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 572418011489 FAD binding site [chemical binding]; other site 572418011490 substrate binding site [chemical binding]; other site 572418011491 catalytic residues [active] 572418011493 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 572418011494 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 572418011495 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 572418011496 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418011497 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418011498 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 572418011499 active site 572418011500 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 572418011501 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418011502 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418011503 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 572418011505 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 572418011506 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418011507 acyl-activating enzyme (AAE) consensus motif; other site 572418011508 active site 572418011509 Cutinase; Region: Cutinase; pfam01083 572418011510 Predicted esterase [General function prediction only]; Region: COG0627 572418011512 Putative esterase; Region: Esterase; pfam00756 572418011513 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 572418011515 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 572418011516 active site 572418011517 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 572418011518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 572418011519 active site 572418011520 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 572418011521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418011522 UDP-galactopyranose mutase; Region: GLF; pfam03275 572418011523 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 572418011524 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 572418011525 amidase catalytic site [active] 572418011526 Zn binding residues [ion binding]; other site 572418011527 substrate binding site [chemical binding]; other site 572418011528 LGFP repeat; Region: LGFP; pfam08310 572418011530 PE family; Region: PE; pfam00934 572418011531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 572418011532 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572418011533 active site 572418011534 motif I; other site 572418011535 motif II; other site 572418011536 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 572418011537 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418011538 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572418011539 putative acyl-acceptor binding pocket; other site 572418011540 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418011541 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572418011542 putative acyl-acceptor binding pocket; other site 572418011543 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572418011544 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572418011545 putative acyl-acceptor binding pocket; other site 572418011546 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 572418011547 Phosphotransferase enzyme family; Region: APH; pfam01636 572418011548 active site 572418011549 ATP binding site [chemical binding]; other site 572418011550 antibiotic binding site [chemical binding]; other site 572418011551 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 572418011552 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 572418011553 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 572418011554 iron-sulfur cluster [ion binding]; other site 572418011555 [2Fe-2S] cluster binding site [ion binding]; other site 572418011557 Condensation domain; Region: Condensation; pfam00668 572418011558 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 572418011559 PE-PPE domain; Region: PE-PPE; pfam08237 572418011560 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 572418011561 Condensation domain; Region: Condensation; pfam00668 572418011563 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 572418011564 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 572418011565 active site 572418011566 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 572418011567 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 572418011568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572418011569 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 572418011570 Enoylreductase; Region: PKS_ER; smart00829 572418011571 NAD(P) binding site [chemical binding]; other site 572418011572 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 572418011573 KR domain; Region: KR; pfam08659 572418011574 putative NADP binding site [chemical binding]; other site 572418011575 active site 572418011576 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 572418011579 acyl-CoA synthetase; Validated; Region: PRK05850 572418011580 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 572418011581 acyl-activating enzyme (AAE) consensus motif; other site 572418011582 active site 572418011583 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 572418011584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 572418011585 Probable transposase; Region: OrfB_IS605; pfam01385 572418011586 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 572418011587 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 572418011588 catalytic residues [active] 572418011589 catalytic nucleophile [active] 572418011591 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 572418011592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418011593 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 572418011594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418011595 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 572418011596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 572418011597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 572418011598 Cupin domain; Region: Cupin_2; cl17218 572418011599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 572418011600 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 572418011601 seryl-tRNA synthetase; Provisional; Region: PRK05431 572418011602 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 572418011603 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 572418011604 dimer interface [polypeptide binding]; other site 572418011605 active site 572418011606 motif 1; other site 572418011607 motif 2; other site 572418011608 motif 3; other site 572418011610 Septum formation; Region: Septum_form; pfam13845 572418011611 Septum formation; Region: Septum_form; pfam13845 572418011614 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 572418011615 catalytic core [active] 572418011617 prephenate dehydratase; Provisional; Region: PRK11898 572418011618 Prephenate dehydratase; Region: PDT; pfam00800 572418011619 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 572418011620 putative L-Phe binding site [chemical binding]; other site 572418011622 Transcriptional regulator [Transcription]; Region: LytR; COG1316 572418011623 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 572418011624 Ferritin-like domain; Region: Ferritin; pfam00210 572418011625 ferroxidase diiron center [ion binding]; other site 572418011626 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 572418011627 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 572418011628 putative active site [active] 572418011629 catalytic site [active] 572418011630 putative metal binding site [ion binding]; other site 572418011631 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 572418011632 Transposase; Region: DEDD_Tnp_IS110; pfam01548 572418011634 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 572418011635 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 572418011636 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 572418011638 Predicted membrane protein [Function unknown]; Region: COG2119 572418011639 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 572418011640 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 572418011641 Fimbrial protein; Region: Fimbrial; cl01416 572418011642 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 572418011643 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 572418011644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 572418011645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 572418011646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 572418011647 hypothetical protein; Provisional; Region: PRK07945 572418011648 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 572418011649 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 572418011650 active site 572418011651 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 572418011652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 572418011653 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 572418011654 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 572418011655 active site 572418011656 dimer interface [polypeptide binding]; other site 572418011657 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 572418011658 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 572418011659 active site 572418011660 FMN binding site [chemical binding]; other site 572418011661 substrate binding site [chemical binding]; other site 572418011662 3Fe-4S cluster binding site [ion binding]; other site 572418011663 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 572418011664 domain interface; other site 572418011665 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 572418011667 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 572418011668 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 572418011669 EspG family; Region: ESX-1_EspG; pfam14011 572418011670 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 572418011671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418011672 Walker A motif; other site 572418011673 ATP binding site [chemical binding]; other site 572418011674 Walker B motif; other site 572418011675 arginine finger; other site 572418011677 Protein of unknown function (DUF690); Region: DUF690; pfam05108 572418011678 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 572418011679 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418011681 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 572418011682 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418011683 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418011686 PE family; Region: PE; pfam00934 572418011687 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 572418011688 PPE family; Region: PPE; pfam00823 572418011689 Proteins of 100 residues with WXG; Region: WXG100; cl02005 572418011690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 572418011691 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 572418011692 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 572418011694 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 572418011695 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 572418011696 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 572418011697 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 572418011698 active site 572418011699 catalytic residues [active] 572418011700 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 572418011701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 572418011702 Walker A motif; other site 572418011703 ATP binding site [chemical binding]; other site 572418011704 Walker B motif; other site 572418011705 arginine finger; other site 572418011707 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 572418011712 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 572418011713 EspG family; Region: ESX-1_EspG; pfam14011 572418011714 Proteins of 100 residues with WXG; Region: WXG100; cl02005 572418011715 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 572418011716 PPE family; Region: PPE; pfam00823 572418011717 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 572418011718 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418011719 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 572418011720 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418011721 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 572418011724 Protein of unknown function (DUF690); Region: DUF690; pfam05108 572418011725 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 572418011726 catalytic residue [active] 572418011727 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 572418011728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 572418011729 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 572418011730 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 572418011731 active site 572418011732 NTP binding site [chemical binding]; other site 572418011733 metal binding triad [ion binding]; metal-binding site 572418011734 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 572418011735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 572418011736 Zn2+ binding site [ion binding]; other site 572418011737 Mg2+ binding site [ion binding]; other site 572418011738 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 572418011743 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 572418011744 active site 572418011745 Ap6A binding site [chemical binding]; other site 572418011746 nudix motif; other site 572418011747 metal binding site [ion binding]; metal-binding site 572418011749 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 572418011750 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 572418011752 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 572418011753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 572418011754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 572418011756 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572418011757 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 572418011758 catalytic residues [active] 572418011760 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 572418011761 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 572418011762 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 572418011763 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 572418011764 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 572418011765 active site 572418011766 metal binding site [ion binding]; metal-binding site 572418011767 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 572418011768 ParB-like nuclease domain; Region: ParB; smart00470 572418011769 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572418011770 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572418011771 P-loop; other site 572418011772 Magnesium ion binding site [ion binding]; other site 572418011773 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 572418011774 Magnesium ion binding site [ion binding]; other site 572418011775 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 572418011776 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 572418011777 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 572418011778 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 572418011779 G-X-X-G motif; other site 572418011780 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 572418011781 RxxxH motif; other site 572418011782 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 572418011783 Uncharacterized conserved protein [Function unknown]; Region: COG0759 572418011784 ribonuclease P; Reviewed; Region: rnpA; PRK00588 572418011786 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399