-- dump date 20140619_151100 -- class Genbank::misc_feature -- table misc_feature_note -- id note 243243000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 243243000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243000003 Walker A motif; other site 243243000004 ATP binding site [chemical binding]; other site 243243000005 Walker B motif; other site 243243000006 arginine finger; other site 243243000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243243000008 DnaA box-binding interface [nucleotide binding]; other site 243243000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 243243000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 243243000011 putative DNA binding surface [nucleotide binding]; other site 243243000012 dimer interface [polypeptide binding]; other site 243243000013 beta-clamp/clamp loader binding surface; other site 243243000014 beta-clamp/translesion DNA polymerase binding surface; other site 243243000015 recombination protein F; Reviewed; Region: recF; PRK00064 243243000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 243243000017 Walker A/P-loop; other site 243243000018 ATP binding site [chemical binding]; other site 243243000019 Q-loop/lid; other site 243243000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243000021 ABC transporter signature motif; other site 243243000022 Walker B; other site 243243000023 D-loop; other site 243243000024 H-loop/switch region; other site 243243000025 hypothetical protein; Provisional; Region: PRK03195 243243000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 243243000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243000028 Mg2+ binding site [ion binding]; other site 243243000029 G-X-G motif; other site 243243000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243243000031 anchoring element; other site 243243000032 dimer interface [polypeptide binding]; other site 243243000033 ATP binding site [chemical binding]; other site 243243000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 243243000035 active site 243243000036 putative metal-binding site [ion binding]; other site 243243000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243243000038 DNA gyrase subunit A; Validated; Region: PRK05560 243243000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243243000040 CAP-like domain; other site 243243000041 active site 243243000042 primary dimer interface [polypeptide binding]; other site 243243000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243243000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243243000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243243000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243243000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243243000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243243000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 243243000050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243000051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000052 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243000053 Cytochrome P450; Region: p450; cl12078 243243000054 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 243243000055 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 243243000056 active site 243243000057 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 243243000058 putative septation inhibitor protein; Reviewed; Region: PRK00159 243243000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 243243000060 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 243243000061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 243243000062 Glutamine amidotransferase class-I; Region: GATase; pfam00117 243243000063 glutamine binding [chemical binding]; other site 243243000064 catalytic triad [active] 243243000065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243000066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243243000067 active site 243243000068 ATP binding site [chemical binding]; other site 243243000069 substrate binding site [chemical binding]; other site 243243000070 activation loop (A-loop); other site 243243000071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243243000072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 243243000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 243243000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 243243000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 243243000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 243243000077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243000078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243243000079 active site 243243000080 ATP binding site [chemical binding]; other site 243243000081 substrate binding site [chemical binding]; other site 243243000082 activation loop (A-loop); other site 243243000083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243243000084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243243000085 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 243243000086 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 243243000087 active site 243243000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243000089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243000090 phosphopeptide binding site; other site 243243000091 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 243243000092 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243000093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243000094 phosphopeptide binding site; other site 243243000095 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243000096 DinB superfamily; Region: DinB_2; pfam12867 243243000097 acyl carrier protein; Validated; Region: PRK05883 243243000098 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 243243000099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243000100 acyl-activating enzyme (AAE) consensus motif; other site 243243000101 AMP binding site [chemical binding]; other site 243243000102 active site 243243000103 CoA binding site [chemical binding]; other site 243243000104 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 243243000105 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243000106 MULE transposase domain; Region: MULE; pfam10551 243243000107 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243000108 MULE transposase domain; Region: MULE; pfam10551 243243000109 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243000110 MULE transposase domain; Region: MULE; pfam10551 243243000111 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243000112 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243000113 active site 243243000114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243000115 Coenzyme A binding pocket [chemical binding]; other site 243243000116 Pirin-related protein [General function prediction only]; Region: COG1741 243243000117 Pirin; Region: Pirin; pfam02678 243243000118 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 243243000119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243000120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243000121 active site 243243000122 Transcription factor WhiB; Region: Whib; pfam02467 243243000123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243243000124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243000125 non-specific DNA binding site [nucleotide binding]; other site 243243000126 salt bridge; other site 243243000127 sequence-specific DNA binding site [nucleotide binding]; other site 243243000128 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243243000129 NlpC/P60 family; Region: NLPC_P60; pfam00877 243243000130 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 243243000131 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 243243000132 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 243243000133 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 243243000134 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 243243000135 TIGR03084 family protein; Region: TIGR03084 243243000136 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 243243000137 Wyosine base formation; Region: Wyosine_form; pfam08608 243243000138 H+ Antiporter protein; Region: 2A0121; TIGR00900 243243000139 hypothetical protein; Validated; Region: PRK00228 243243000140 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 243243000141 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 243243000142 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243243000143 active site 243243000144 HIGH motif; other site 243243000145 nucleotide binding site [chemical binding]; other site 243243000146 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243243000147 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243243000148 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243243000149 active site 243243000150 KMSKS motif; other site 243243000151 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 243243000152 tRNA binding surface [nucleotide binding]; other site 243243000153 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 243243000154 short chain dehydrogenase; Provisional; Region: PRK08219 243243000155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243000156 NAD(P) binding site [chemical binding]; other site 243243000157 active site 243243000158 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243243000159 MarR family; Region: MarR; pfam01047 243243000160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243000161 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243243000162 Walker A/P-loop; other site 243243000163 ATP binding site [chemical binding]; other site 243243000164 Q-loop/lid; other site 243243000165 ABC transporter signature motif; other site 243243000166 Walker B; other site 243243000167 D-loop; other site 243243000168 H-loop/switch region; other site 243243000169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243243000170 substrate binding pocket [chemical binding]; other site 243243000171 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243243000172 membrane-bound complex binding site; other site 243243000173 hinge residues; other site 243243000174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243000175 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 243243000176 dimer interface [polypeptide binding]; other site 243243000177 conserved gate region; other site 243243000178 putative PBP binding loops; other site 243243000179 ABC-ATPase subunit interface; other site 243243000180 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243243000181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243000182 DNA-binding site [nucleotide binding]; DNA binding site 243243000183 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 243243000184 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243000185 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243000186 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 243243000187 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243243000188 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243000189 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243000190 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 243243000191 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 243243000192 Predicted transcriptional regulators [Transcription]; Region: COG1695 243243000193 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 243243000194 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 243243000195 Transglycosylase; Region: Transgly; pfam00912 243243000196 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 243243000197 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243243000198 Predicted integral membrane protein [Function unknown]; Region: COG5650 243243000199 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243243000200 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 243243000201 conserved cys residue [active] 243243000202 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 243243000203 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 243243000204 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 243243000205 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 243243000206 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 243243000207 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 243243000208 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243243000209 Walker A motif; other site 243243000210 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 243243000211 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 243243000212 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 243243000213 ATP binding site [chemical binding]; other site 243243000214 Walker B motif; other site 243243000215 DNA binding loops [nucleotide binding] 243243000216 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243000217 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 243243000218 putative acyl-acceptor binding pocket; other site 243243000219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243000220 S-adenosylmethionine binding site [chemical binding]; other site 243243000221 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 243243000222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000223 Transport protein; Region: actII; TIGR00833 243243000224 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243000225 classical (c) SDRs; Region: SDR_c; cd05233 243243000226 NAD(P) binding site [chemical binding]; other site 243243000227 active site 243243000228 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243243000229 FAD binding domain; Region: FAD_binding_4; pfam01565 243243000230 Berberine and berberine like; Region: BBE; pfam08031 243243000231 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243243000232 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243243000233 ligand binding site [chemical binding]; other site 243243000234 flexible hinge region; other site 243243000235 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243243000236 putative switch regulator; other site 243243000237 non-specific DNA interactions [nucleotide binding]; other site 243243000238 DNA binding site [nucleotide binding] 243243000239 sequence specific DNA binding site [nucleotide binding]; other site 243243000240 putative cAMP binding site [chemical binding]; other site 243243000241 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243000242 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243243000243 active site 243243000244 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243000245 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243000246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243243000247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243000248 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243243000249 dimerization interface [polypeptide binding]; other site 243243000250 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243243000251 EamA-like transporter family; Region: EamA; pfam00892 243243000252 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 243243000253 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243243000254 Permease; Region: Permease; pfam02405 243243000255 mce related protein; Region: MCE; pfam02470 243243000256 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243000257 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243243000258 mce related protein; Region: MCE; pfam02470 243243000259 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243000260 mce related protein; Region: MCE; pfam02470 243243000261 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243000262 mce related protein; Region: MCE; pfam02470 243243000263 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243243000264 mce related protein; Region: MCE; pfam02470 243243000265 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243000266 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243000267 mce related protein; Region: MCE; pfam02470 243243000268 Mannan-binding protein; Region: MVL; pfam12151 243243000269 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 243243000270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243000271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243000273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000274 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 243243000275 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243000276 PPE family; Region: PPE; pfam00823 243243000277 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 243243000278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243000279 S-adenosylmethionine binding site [chemical binding]; other site 243243000280 Domain of unknown function (DUF385); Region: DUF385; pfam04075 243243000281 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243243000282 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243243000283 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243243000284 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243000285 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243000286 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243243000287 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 243243000288 putative ligand binding site [chemical binding]; other site 243243000289 NAD binding site [chemical binding]; other site 243243000290 catalytic site [active] 243243000291 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243243000292 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243000293 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243000294 PhoU domain; Region: PhoU; pfam01895 243243000295 Hemerythrin-like domain; Region: Hr-like; cd12108 243243000296 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243243000297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243000298 S-adenosylmethionine binding site [chemical binding]; other site 243243000299 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243243000300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243000301 active site 243243000302 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 243243000303 Predicted transcriptional regulators [Transcription]; Region: COG1695 243243000304 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 243243000305 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 243243000306 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243000307 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 243243000308 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243000309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243000310 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243243000311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243000312 Walker A/P-loop; other site 243243000313 ATP binding site [chemical binding]; other site 243243000314 Q-loop/lid; other site 243243000315 ABC transporter signature motif; other site 243243000316 Walker B; other site 243243000317 D-loop; other site 243243000318 H-loop/switch region; other site 243243000319 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 243243000320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243243000321 substrate binding pocket [chemical binding]; other site 243243000322 membrane-bound complex binding site; other site 243243000323 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 243243000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243000325 dimer interface [polypeptide binding]; other site 243243000326 conserved gate region; other site 243243000327 putative PBP binding loops; other site 243243000328 ABC-ATPase subunit interface; other site 243243000329 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 243243000330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243000331 hypothetical protein; Provisional; Region: PRK01346 243243000332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243000333 Coenzyme A binding pocket [chemical binding]; other site 243243000334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243000335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243000336 active site 243243000337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243000338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243000340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243000341 dimer interface [polypeptide binding]; other site 243243000342 phosphorylation site [posttranslational modification] 243243000343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243000344 ATP binding site [chemical binding]; other site 243243000345 Mg2+ binding site [ion binding]; other site 243243000346 G-X-G motif; other site 243243000347 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243000348 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243000349 substrate binding site [chemical binding]; other site 243243000350 oxyanion hole (OAH) forming residues; other site 243243000351 trimer interface [polypeptide binding]; other site 243243000352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243000353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 243243000355 putative dimer interface [polypeptide binding]; other site 243243000356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243000357 ligand binding site [chemical binding]; other site 243243000358 Zn binding site [ion binding]; other site 243243000359 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 243243000360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 243243000361 EspG family; Region: ESX-1_EspG; pfam14011 243243000362 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 243243000363 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 243243000364 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 243243000365 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243243000366 catalytic residues [active] 243243000367 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243243000368 catalytic residues [active] 243243000369 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 243243000370 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 243243000371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243000372 Walker A motif; other site 243243000373 ATP binding site [chemical binding]; other site 243243000374 Walker B motif; other site 243243000375 arginine finger; other site 243243000376 Domain of unknown function (DUF385); Region: DUF385; cl04387 243243000377 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 243243000378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243000379 NAD(P) binding site [chemical binding]; other site 243243000380 active site 243243000381 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 243243000382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243000383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243000384 DNA binding residues [nucleotide binding] 243243000385 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 243243000386 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 243243000387 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 243243000388 active site 243243000389 dimer interface [polypeptide binding]; other site 243243000390 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 243243000391 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 243243000392 active site 243243000393 FMN binding site [chemical binding]; other site 243243000394 substrate binding site [chemical binding]; other site 243243000395 3Fe-4S cluster binding site [ion binding]; other site 243243000396 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 243243000397 domain interface; other site 243243000398 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 243243000399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243000400 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 243243000401 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243000402 hypothetical protein; Provisional; Region: PRK07945 243243000403 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 243243000404 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 243243000405 active site 243243000406 DNA polymerase IV; Validated; Region: PRK03858 243243000407 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243243000408 active site 243243000409 DNA binding site [nucleotide binding] 243243000410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243000411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000412 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243000413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243000414 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 243243000415 CopC domain; Region: CopC; pfam04234 243243000416 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 243243000417 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 243243000418 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 243243000419 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 243243000420 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 243243000421 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 243243000422 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 243243000423 putative active site [active] 243243000424 catalytic site [active] 243243000425 putative metal binding site [ion binding]; other site 243243000426 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 243243000427 prephenate dehydratase; Provisional; Region: PRK11898 243243000428 Prephenate dehydratase; Region: PDT; pfam00800 243243000429 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 243243000430 putative L-Phe binding site [chemical binding]; other site 243243000431 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 243243000432 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243000433 catalytic core [active] 243243000434 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 243243000435 Septum formation; Region: Septum_form; pfam13845 243243000436 Septum formation; Region: Septum_form; pfam13845 243243000437 seryl-tRNA synthetase; Provisional; Region: PRK05431 243243000438 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 243243000439 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 243243000440 dimer interface [polypeptide binding]; other site 243243000441 active site 243243000442 motif 1; other site 243243000443 motif 2; other site 243243000444 motif 3; other site 243243000445 Cupin domain; Region: Cupin_2; cl17218 243243000446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243243000447 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243243000448 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243243000449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243000450 S-adenosylmethionine binding site [chemical binding]; other site 243243000451 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 243243000452 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243000453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000454 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 243243000455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243000456 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 243243000457 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 243243000458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243243000459 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243243000460 iron-sulfur cluster [ion binding]; other site 243243000461 [2Fe-2S] cluster binding site [ion binding]; other site 243243000462 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243000463 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243243000464 putative acyl-acceptor binding pocket; other site 243243000465 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243000466 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243243000467 putative acyl-acceptor binding pocket; other site 243243000468 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243000469 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243243000470 putative acyl-acceptor binding pocket; other site 243243000471 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 243243000472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243000473 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 243243000474 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 243243000475 amidase catalytic site [active] 243243000476 Zn binding residues [ion binding]; other site 243243000477 substrate binding site [chemical binding]; other site 243243000478 LGFP repeat; Region: LGFP; pfam08310 243243000479 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 243243000480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243000481 UDP-galactopyranose mutase; Region: GLF; pfam03275 243243000482 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243243000483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243243000484 active site 243243000485 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243243000486 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 243243000487 Putative esterase; Region: Esterase; pfam00756 243243000488 Putative esterase; Region: Esterase; pfam00756 243243000489 Cutinase; Region: Cutinase; pfam01083 243243000490 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 243243000491 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243243000492 acyl-activating enzyme (AAE) consensus motif; other site 243243000493 active site 243243000494 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243000495 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243000496 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243243000497 active site 243243000498 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243243000499 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243000500 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243000501 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 243243000502 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 243243000503 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243243000504 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 243243000505 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243000506 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243000507 Helix-turn-helix domain; Region: HTH_18; pfam12833 243243000508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243243000509 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243000510 active site 243243000511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243000512 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 243243000513 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 243243000514 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 243243000515 DNA binding site [nucleotide binding] 243243000516 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243000517 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243000518 phosphopeptide binding site; other site 243243000519 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 243243000520 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 243243000521 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 243243000522 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 243243000523 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 243243000524 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 243243000525 short chain dehydrogenase; Provisional; Region: PRK07904 243243000526 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243243000527 NAD(P) binding site [chemical binding]; other site 243243000528 active site 243243000529 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243243000530 FAD binding domain; Region: FAD_binding_4; pfam01565 243243000531 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 243243000532 Predicted membrane protein [Function unknown]; Region: COG2246 243243000533 GtrA-like protein; Region: GtrA; pfam04138 243243000534 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 243243000535 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243243000536 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 243243000537 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 243243000538 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 243243000539 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243243000540 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243243000541 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243243000542 active site 243243000543 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 243243000544 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 243243000545 Walker A/P-loop; other site 243243000546 ATP binding site [chemical binding]; other site 243243000547 Q-loop/lid; other site 243243000548 ABC transporter signature motif; other site 243243000549 Walker B; other site 243243000550 D-loop; other site 243243000551 H-loop/switch region; other site 243243000552 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 243243000553 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243243000554 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243000555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243000556 catalytic residue [active] 243243000557 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 243243000558 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 243243000559 NAD(P) binding site [chemical binding]; other site 243243000560 peptide chain release factor 1, archaeal and eukaryotic forms; Region: aRF1/eRF1; TIGR03676 243243000561 eRF1 domain 3; Region: eRF1_3; pfam03465 243243000562 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243243000563 Beta-lactamase; Region: Beta-lactamase; pfam00144 243243000564 enoyl-CoA hydratase; Provisional; Region: PRK06142 243243000565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243000566 substrate binding site [chemical binding]; other site 243243000567 oxyanion hole (OAH) forming residues; other site 243243000568 trimer interface [polypeptide binding]; other site 243243000569 TIGR03086 family protein; Region: TIGR03086 243243000570 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 243243000571 GXWXG protein; Region: GXWXG; pfam14231 243243000572 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 243243000573 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 243243000574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243000575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243000576 homodimer interface [polypeptide binding]; other site 243243000577 catalytic residue [active] 243243000578 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 243243000579 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 243243000580 Int/Topo IB signature motif; other site 243243000581 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243243000582 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243243000583 Helix-turn-helix domain; Region: HTH_17; pfam12728 243243000584 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 243243000585 polymerase nucleotide-binding site; other site 243243000586 DNA-binding residues [nucleotide binding]; DNA binding site 243243000587 nucleotide binding site [chemical binding]; other site 243243000588 primase nucleotide-binding site [nucleotide binding]; other site 243243000589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243000590 sequence-specific DNA binding site [nucleotide binding]; other site 243243000591 salt bridge; other site 243243000592 Helix-turn-helix domain; Region: HTH_17; pfam12728 243243000593 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243243000594 DNA methylase; Region: N6_N4_Mtase; cl17433 243243000595 DNA methylase; Region: N6_N4_Mtase; cl17433 243243000596 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 243243000597 Helix-turn-helix domain; Region: HTH_17; cl17695 243243000598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243000599 Walker A/P-loop; other site 243243000600 ATP binding site [chemical binding]; other site 243243000601 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 243243000602 polymerase nucleotide-binding site; other site 243243000603 DNA-binding residues [nucleotide binding]; DNA binding site 243243000604 nucleotide binding site [chemical binding]; other site 243243000605 primase nucleotide-binding site [nucleotide binding]; other site 243243000606 active site 243243000607 putative DNA-binding cleft [nucleotide binding]; other site 243243000608 dimer interface [polypeptide binding]; other site 243243000609 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 243243000610 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 243243000611 catalytic residues [active] 243243000612 Helix-turn-helix domain; Region: HTH_17; cl17695 243243000613 envelope glycoprotein C; Provisional; Region: PHA03269 243243000614 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 243243000615 DNA binding site [nucleotide binding] 243243000616 dimer interface [polypeptide binding]; other site 243243000617 active site 243243000618 Int/Topo IB signature motif; other site 243243000619 Phosphotransferase enzyme family; Region: APH; pfam01636 243243000620 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243000621 putative active site [active] 243243000622 putative substrate binding site [chemical binding]; other site 243243000623 ATP binding site [chemical binding]; other site 243243000624 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243000625 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243000626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243000627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243000628 active site 243243000629 phosphorylation site [posttranslational modification] 243243000630 intermolecular recognition site; other site 243243000631 dimerization interface [polypeptide binding]; other site 243243000632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243000633 DNA binding site [nucleotide binding] 243243000634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243000635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243000636 dimerization interface [polypeptide binding]; other site 243243000637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243000638 dimer interface [polypeptide binding]; other site 243243000639 phosphorylation site [posttranslational modification] 243243000640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243000641 ATP binding site [chemical binding]; other site 243243000642 Mg2+ binding site [ion binding]; other site 243243000643 G-X-G motif; other site 243243000644 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 243243000645 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 243243000646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243000647 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243243000648 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 243243000649 NAD(P) binding site [chemical binding]; other site 243243000650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243000651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000652 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 243243000653 classical (c) SDRs; Region: SDR_c; cd05233 243243000654 NAD(P) binding site [chemical binding]; other site 243243000655 active site 243243000656 Phosphotransferase enzyme family; Region: APH; pfam01636 243243000657 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243000658 putative active site [active] 243243000659 putative substrate binding site [chemical binding]; other site 243243000660 ATP binding site [chemical binding]; other site 243243000661 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 243243000662 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243000663 catalytic core [active] 243243000664 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243000665 putative active site [active] 243243000666 putative substrate binding site [chemical binding]; other site 243243000667 ATP binding site [chemical binding]; other site 243243000668 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 243243000669 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 243243000670 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 243243000671 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 243243000672 Walker A/P-loop; other site 243243000673 ATP binding site [chemical binding]; other site 243243000674 Q-loop/lid; other site 243243000675 ABC transporter signature motif; other site 243243000676 Walker B; other site 243243000677 D-loop; other site 243243000678 H-loop/switch region; other site 243243000679 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 243243000680 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 243243000681 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 243243000682 prephenate dehydrogenase; Validated; Region: PRK06545 243243000683 prephenate dehydrogenase; Validated; Region: PRK08507 243243000684 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 243243000685 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243243000686 nucleoside/Zn binding site; other site 243243000687 dimer interface [polypeptide binding]; other site 243243000688 catalytic motif [active] 243243000689 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 243243000690 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 243243000691 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243000692 MULE transposase domain; Region: MULE; pfam10551 243243000693 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 243243000694 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 243243000695 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 243243000696 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243000697 active site 243243000698 metal binding site [ion binding]; metal-binding site 243243000699 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 243243000700 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243000701 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243000702 Transcriptional regulators [Transcription]; Region: GntR; COG1802 243243000703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243000704 DNA-binding site [nucleotide binding]; DNA binding site 243243000705 FCD domain; Region: FCD; pfam07729 243243000706 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243243000707 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243243000708 active site 243243000709 non-prolyl cis peptide bond; other site 243243000710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243000711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243000712 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 243243000713 pyruvate carboxylase; Reviewed; Region: PRK12999 243243000714 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243243000715 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243243000716 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243243000717 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 243243000718 active site 243243000719 catalytic residues [active] 243243000720 metal binding site [ion binding]; metal-binding site 243243000721 homodimer binding site [polypeptide binding]; other site 243243000722 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243243000723 carboxyltransferase (CT) interaction site; other site 243243000724 biotinylation site [posttranslational modification]; other site 243243000725 citrate synthase; Provisional; Region: PRK14033 243243000726 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 243243000727 dimer interface [polypeptide binding]; other site 243243000728 active site 243243000729 citrylCoA binding site [chemical binding]; other site 243243000730 oxalacetate/citrate binding site [chemical binding]; other site 243243000731 coenzyme A binding site [chemical binding]; other site 243243000732 catalytic triad [active] 243243000733 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 243243000734 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 243243000735 tetramer interface [polypeptide binding]; other site 243243000736 active site 243243000737 Mg2+/Mn2+ binding site [ion binding]; other site 243243000738 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 243243000739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243243000740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243000741 non-specific DNA binding site [nucleotide binding]; other site 243243000742 salt bridge; other site 243243000743 sequence-specific DNA binding site [nucleotide binding]; other site 243243000744 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 243243000745 Domain of unknown function (DUF955); Region: DUF955; pfam06114 243243000746 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 243243000747 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243243000748 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 243243000749 substrate binding site [chemical binding]; other site 243243000750 ATP binding site [chemical binding]; other site 243243000751 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 243243000752 dimerization interface [polypeptide binding]; other site 243243000753 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243243000754 NAD binding site [chemical binding]; other site 243243000755 ligand binding site [chemical binding]; other site 243243000756 catalytic site [active] 243243000757 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243000758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243000760 classical (c) SDRs; Region: SDR_c; cd05233 243243000761 NAD(P) binding site [chemical binding]; other site 243243000762 active site 243243000763 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243243000764 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243000765 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243243000766 short chain dehydrogenase; Provisional; Region: PRK07856 243243000767 classical (c) SDRs; Region: SDR_c; cd05233 243243000768 NAD(P) binding site [chemical binding]; other site 243243000769 active site 243243000770 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243000771 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243000772 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 243243000773 nudix motif; other site 243243000774 haloalkane dehalogenase; Provisional; Region: PRK00870 243243000775 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243000776 Cytochrome P450; Region: p450; cl12078 243243000777 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 243243000778 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 243243000779 active site 243243000780 DNA binding site [nucleotide binding] 243243000781 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 243243000782 DNA binding site [nucleotide binding] 243243000783 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 243243000784 nucleotide binding site [chemical binding]; other site 243243000785 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 243243000786 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243000787 Cytochrome P450; Region: p450; cl12078 243243000788 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 243243000789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243000790 Cutinase; Region: Cutinase; pfam01083 243243000791 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243000792 CHAT domain; Region: CHAT; cl17868 243243000793 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 243243000794 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 243243000795 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243000796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243000797 catalytic residue [active] 243243000798 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 243243000799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243000800 Walker A motif; other site 243243000801 ATP binding site [chemical binding]; other site 243243000802 Walker B motif; other site 243243000803 arginine finger; other site 243243000804 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 243243000805 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243243000806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243000807 S-adenosylmethionine binding site [chemical binding]; other site 243243000808 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243243000809 FAD binding domain; Region: FAD_binding_4; pfam01565 243243000810 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 243243000811 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 243243000812 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 243243000813 active site 243243000814 metal binding site [ion binding]; metal-binding site 243243000815 hypothetical protein; Validated; Region: PRK00153 243243000816 recombination protein RecR; Reviewed; Region: recR; PRK00076 243243000817 RecR protein; Region: RecR; pfam02132 243243000818 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 243243000819 putative active site [active] 243243000820 putative metal-binding site [ion binding]; other site 243243000821 tetramer interface [polypeptide binding]; other site 243243000822 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 243243000823 catalytic triad [active] 243243000824 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 243243000825 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 243243000826 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 243243000827 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 243243000828 active site 243243000829 catalytic site [active] 243243000830 substrate binding site [chemical binding]; other site 243243000831 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 243243000832 Dimer interface [polypeptide binding]; other site 243243000833 BRCT sequence motif; other site 243243000834 2-isopropylmalate synthase; Validated; Region: PRK03739 243243000835 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 243243000836 active site 243243000837 catalytic residues [active] 243243000838 metal binding site [ion binding]; metal-binding site 243243000839 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 243243000840 aspartate kinase; Reviewed; Region: PRK06635 243243000841 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 243243000842 putative nucleotide binding site [chemical binding]; other site 243243000843 putative catalytic residues [active] 243243000844 putative Mg ion binding site [ion binding]; other site 243243000845 putative aspartate binding site [chemical binding]; other site 243243000846 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 243243000847 putative allosteric regulatory site; other site 243243000848 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 243243000849 putative allosteric regulatory residue; other site 243243000850 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 243243000851 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243243000852 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 243243000853 PknH-like extracellular domain; Region: PknH_C; pfam14032 243243000854 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 243243000855 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 243243000856 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 243243000857 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 243243000858 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 243243000859 putative active site [active] 243243000860 putative dimer interface [polypeptide binding]; other site 243243000861 Uncharacterized conserved protein [Function unknown]; Region: COG4301 243243000862 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 243243000863 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243000864 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243243000865 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243000866 catalytic residue [active] 243243000867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243000868 S-adenosylmethionine binding site [chemical binding]; other site 243243000869 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 243243000870 glycerol kinase; Provisional; Region: glpK; PRK00047 243243000871 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243243000872 nucleotide binding site [chemical binding]; other site 243243000873 Predicted transcriptional regulators [Transcription]; Region: COG1695 243243000874 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 243243000875 Predicted membrane protein/domain [Function unknown]; Region: COG1714 243243000876 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 243243000877 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243243000878 Protein of unknown function DUF58; Region: DUF58; pfam01882 243243000879 MoxR-like ATPases [General function prediction only]; Region: COG0714 243243000880 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 243243000881 Walker A motif; other site 243243000882 ATP binding site [chemical binding]; other site 243243000883 Walker B motif; other site 243243000884 arginine finger; other site 243243000885 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 243243000886 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 243243000887 Yqey-like protein; Region: YqeY; pfam09424 243243000888 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 243243000889 G1 box; other site 243243000890 putative GEF interaction site [polypeptide binding]; other site 243243000891 GTP/Mg2+ binding site [chemical binding]; other site 243243000892 Switch I region; other site 243243000893 G2 box; other site 243243000894 G3 box; other site 243243000895 Switch II region; other site 243243000896 G4 box; other site 243243000897 G5 box; other site 243243000898 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 243243000899 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 243243000900 selenocysteine synthase; Provisional; Region: PRK04311 243243000901 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 243243000902 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243000903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243000904 catalytic residue [active] 243243000905 selenophosphate synthetase; Provisional; Region: PRK00943 243243000906 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 243243000907 dimerization interface [polypeptide binding]; other site 243243000908 putative ATP binding site [chemical binding]; other site 243243000909 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243000910 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243000911 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243000912 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243000913 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 243243000914 molybdopterin cofactor binding site; other site 243243000915 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 243243000916 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 243243000917 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243000918 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 243243000919 intracellular protease, PfpI family; Region: PfpI; TIGR01382 243243000920 proposed catalytic triad [active] 243243000921 conserved cys residue [active] 243243000922 putative methyltransferase; Provisional; Region: PRK14967 243243000923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243000924 S-adenosylmethionine binding site [chemical binding]; other site 243243000925 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 243243000926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243243000927 PAS domain; Region: PAS_9; pfam13426 243243000928 putative active site [active] 243243000929 heme pocket [chemical binding]; other site 243243000930 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243243000931 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243243000932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 243243000933 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243243000934 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 243243000935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243000936 ATP binding site [chemical binding]; other site 243243000937 G-X-G motif; other site 243243000938 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 243243000939 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 243243000940 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 243243000941 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243000942 anti sigma factor interaction site; other site 243243000943 regulatory phosphorylation site [posttranslational modification]; other site 243243000944 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 243243000945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243000946 motif II; other site 243243000947 Restriction endonuclease; Region: Mrr_cat; pfam04471 243243000948 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243243000949 GAF domain; Region: GAF; pfam01590 243243000950 ANTAR domain; Region: ANTAR; pfam03861 243243000951 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 243243000952 TIGR03086 family protein; Region: TIGR03086 243243000953 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 243243000954 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 243243000955 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243000956 catalytic residue [active] 243243000957 phosphodiesterase YaeI; Provisional; Region: PRK11340 243243000958 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 243243000959 putative active site [active] 243243000960 putative metal binding site [ion binding]; other site 243243000961 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 243243000962 Transglycosylase; Region: Transgly; pfam00912 243243000963 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243243000964 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 243243000965 Transcription factor WhiB; Region: Whib; pfam02467 243243000966 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 243243000967 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 243243000968 DTAP/Switch II; other site 243243000969 Switch I; other site 243243000970 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 243243000971 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 243243000972 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 243243000973 P loop; other site 243243000974 Nucleotide binding site [chemical binding]; other site 243243000975 DTAP/Switch II; other site 243243000976 Switch I; other site 243243000977 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 243243000978 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 243243000979 homotrimer interaction site [polypeptide binding]; other site 243243000980 putative active site [active] 243243000981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243000982 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243243000983 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243243000984 ligand binding site [chemical binding]; other site 243243000985 flexible hinge region; other site 243243000986 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243243000987 putative switch regulator; other site 243243000988 non-specific DNA interactions [nucleotide binding]; other site 243243000989 DNA binding site [nucleotide binding] 243243000990 sequence specific DNA binding site [nucleotide binding]; other site 243243000991 putative cAMP binding site [chemical binding]; other site 243243000992 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 243243000993 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243243000994 minor groove reading motif; other site 243243000995 helix-hairpin-helix signature motif; other site 243243000996 substrate binding pocket [chemical binding]; other site 243243000997 active site 243243000998 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 243243000999 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243243001000 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243243001001 catalytic residues [active] 243243001002 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 243243001003 putative active site [active] 243243001004 putative CoA binding site [chemical binding]; other site 243243001005 nudix motif; other site 243243001006 metal binding site [ion binding]; metal-binding site 243243001007 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243243001008 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243243001009 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243001010 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 243243001011 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243243001012 acetyl-CoA synthetase; Provisional; Region: PRK00174 243243001013 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 243243001014 active site 243243001015 CoA binding site [chemical binding]; other site 243243001016 acyl-activating enzyme (AAE) consensus motif; other site 243243001017 AMP binding site [chemical binding]; other site 243243001018 acetate binding site [chemical binding]; other site 243243001019 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 243243001020 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 243243001021 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 243243001022 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243243001023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243001024 dimer interface [polypeptide binding]; other site 243243001025 conserved gate region; other site 243243001026 ABC-ATPase subunit interface; other site 243243001027 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 243243001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243001029 dimer interface [polypeptide binding]; other site 243243001030 conserved gate region; other site 243243001031 putative PBP binding loops; other site 243243001032 ABC-ATPase subunit interface; other site 243243001033 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 243243001034 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243243001035 Walker A/P-loop; other site 243243001036 ATP binding site [chemical binding]; other site 243243001037 Q-loop/lid; other site 243243001038 ABC transporter signature motif; other site 243243001039 Walker B; other site 243243001040 D-loop; other site 243243001041 H-loop/switch region; other site 243243001042 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243243001043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243243001044 Walker A/P-loop; other site 243243001045 ATP binding site [chemical binding]; other site 243243001046 Q-loop/lid; other site 243243001047 ABC transporter signature motif; other site 243243001048 Walker B; other site 243243001049 D-loop; other site 243243001050 H-loop/switch region; other site 243243001051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243243001052 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 243243001053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243001054 motif II; other site 243243001055 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 243243001056 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243243001057 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 243243001058 ATP binding site [chemical binding]; other site 243243001059 Walker B motif; other site 243243001060 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243001061 MULE transposase domain; Region: MULE; pfam10551 243243001062 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243001063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243001064 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243001065 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243001066 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243001067 lipid-transfer protein; Provisional; Region: PRK07855 243243001068 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243001069 active site 243243001070 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243001071 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243001072 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243001073 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243001074 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243001075 classical (c) SDRs; Region: SDR_c; cd05233 243243001076 NAD(P) binding site [chemical binding]; other site 243243001077 active site 243243001078 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 243243001079 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 243243001080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243001081 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243001082 active site 243243001083 catalytic tetrad [active] 243243001084 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 243243001085 Putative cyclase; Region: Cyclase; pfam04199 243243001086 Putative cyclase; Region: Cyclase; cl00814 243243001087 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243243001088 MarR family; Region: MarR_2; pfam12802 243243001089 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243001090 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243243001091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243001092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243001093 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 243243001094 Domain of unknown function (DUF336); Region: DUF336; cl01249 243243001095 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 243243001096 Cupin domain; Region: Cupin_2; pfam07883 243243001097 Carboxylesterase family; Region: COesterase; pfam00135 243243001098 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243001099 substrate binding pocket [chemical binding]; other site 243243001100 catalytic triad [active] 243243001101 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 243243001102 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243243001103 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243243001104 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243001105 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 243243001106 homodimer interface [polypeptide binding]; other site 243243001107 putative GKAP docking site [polypeptide binding]; other site 243243001108 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243001109 active site 243243001110 DNA binding site [nucleotide binding] 243243001111 Int/Topo IB signature motif; other site 243243001112 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243243001113 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 243243001114 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243001115 active site 243243001116 DNA binding site [nucleotide binding] 243243001117 Int/Topo IB signature motif; other site 243243001118 Domain of unknown function (DUF955); Region: DUF955; cl01076 243243001119 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 243243001120 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 243243001121 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 243243001122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243001123 ATP binding site [chemical binding]; other site 243243001124 putative Mg++ binding site [ion binding]; other site 243243001125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243001126 nucleotide binding region [chemical binding]; other site 243243001127 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 243243001128 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243243001129 DNA-binding site [nucleotide binding]; DNA binding site 243243001130 RNA-binding motif; other site 243243001131 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 243243001132 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 243243001133 active site 243243001134 interdomain interaction site; other site 243243001135 putative metal-binding site [ion binding]; other site 243243001136 nucleotide binding site [chemical binding]; other site 243243001137 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 243243001138 domain I; other site 243243001139 phosphate binding site [ion binding]; other site 243243001140 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243243001141 domain II; other site 243243001142 domain III; other site 243243001143 nucleotide binding site [chemical binding]; other site 243243001144 DNA binding groove [nucleotide binding] 243243001145 catalytic site [active] 243243001146 domain IV; other site 243243001147 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 243243001148 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 243243001149 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 243243001150 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243001151 dimerization interface [polypeptide binding]; other site 243243001152 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243243001153 cyclase homology domain; Region: CHD; cd07302 243243001154 nucleotidyl binding site; other site 243243001155 metal binding site [ion binding]; metal-binding site 243243001156 dimer interface [polypeptide binding]; other site 243243001157 DNA polymerase III subunit delta'; Validated; Region: PRK07940 243243001158 DNA polymerase III subunit delta'; Validated; Region: PRK08485 243243001159 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 243243001160 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243001161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243001162 NAD(P) binding site [chemical binding]; other site 243243001163 active site 243243001164 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 243243001165 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243243001166 Ligand binding site; other site 243243001167 Putative Catalytic site; other site 243243001168 DXD motif; other site 243243001169 Protein of unknown function (DUF475); Region: DUF475; pfam04332 243243001170 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 243243001171 dimer interface [polypeptide binding]; other site 243243001172 substrate binding site [chemical binding]; other site 243243001173 metal binding sites [ion binding]; metal-binding site 243243001174 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 243243001175 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 243243001176 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 243243001177 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 243243001178 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 243243001179 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 243243001180 Ligand Binding Site [chemical binding]; other site 243243001181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243243001182 active site 243243001183 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 243243001184 PE family; Region: PE; pfam00934 243243001185 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243001186 PPE family; Region: PPE; pfam00823 243243001187 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243001188 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243001189 active site 243243001190 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243243001191 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 243243001192 putative NAD(P) binding site [chemical binding]; other site 243243001193 catalytic Zn binding site [ion binding]; other site 243243001194 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243001195 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 243243001196 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243001197 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243001198 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 243243001199 dimer interface [polypeptide binding]; other site 243243001200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243001201 metal binding site [ion binding]; metal-binding site 243243001202 FtsH Extracellular; Region: FtsH_ext; pfam06480 243243001203 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243243001204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243001205 Walker A motif; other site 243243001206 ATP binding site [chemical binding]; other site 243243001207 Walker B motif; other site 243243001208 arginine finger; other site 243243001209 Peptidase family M41; Region: Peptidase_M41; pfam01434 243243001210 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 243243001211 homodecamer interface [polypeptide binding]; other site 243243001212 GTP cyclohydrolase I; Provisional; Region: PLN03044 243243001213 active site 243243001214 putative catalytic site residues [active] 243243001215 zinc binding site [ion binding]; other site 243243001216 GTP-CH-I/GFRP interaction surface; other site 243243001217 dihydropteroate synthase; Region: DHPS; TIGR01496 243243001218 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 243243001219 substrate binding pocket [chemical binding]; other site 243243001220 dimer interface [polypeptide binding]; other site 243243001221 inhibitor binding site; inhibition site 243243001222 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 243243001223 homooctamer interface [polypeptide binding]; other site 243243001224 active site 243243001225 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 243243001226 catalytic center binding site [active] 243243001227 ATP binding site [chemical binding]; other site 243243001228 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 243243001229 Rossmann-like domain; Region: Rossmann-like; pfam10727 243243001230 Uncharacterized conserved protein [Function unknown]; Region: COG5495 243243001231 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 243243001232 Pantoate-beta-alanine ligase; Region: PanC; cd00560 243243001233 pantoate--beta-alanine ligase; Region: panC; TIGR00018 243243001234 active site 243243001235 ATP-binding site [chemical binding]; other site 243243001236 pantoate-binding site; other site 243243001237 HXXH motif; other site 243243001238 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 243243001239 tetramerization interface [polypeptide binding]; other site 243243001240 active site 243243001241 pantothenate kinase; Reviewed; Region: PRK13318 243243001242 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 243243001243 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 243243001244 dimer interface [polypeptide binding]; other site 243243001245 putative anticodon binding site; other site 243243001246 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243243001247 motif 1; other site 243243001248 dimer interface [polypeptide binding]; other site 243243001249 active site 243243001250 motif 2; other site 243243001251 motif 3; other site 243243001252 Lsr2; Region: Lsr2; pfam11774 243243001253 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 243243001254 Clp amino terminal domain; Region: Clp_N; pfam02861 243243001255 Clp amino terminal domain; Region: Clp_N; pfam02861 243243001256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243001257 Walker A motif; other site 243243001258 ATP binding site [chemical binding]; other site 243243001259 Walker B motif; other site 243243001260 arginine finger; other site 243243001261 UvrB/uvrC motif; Region: UVR; pfam02151 243243001262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243001263 Walker A motif; other site 243243001264 ATP binding site [chemical binding]; other site 243243001265 Walker B motif; other site 243243001266 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243243001267 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 243243001268 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 243243001269 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 243243001270 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 243243001271 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 243243001272 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 243243001273 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 243243001274 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243001275 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 243243001276 catalytic site [active] 243243001277 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 243243001278 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243243001279 minor groove reading motif; other site 243243001280 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 243243001281 helix-hairpin-helix signature motif; other site 243243001282 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 243243001283 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 243243001284 active site clefts [active] 243243001285 zinc binding site [ion binding]; other site 243243001286 dimer interface [polypeptide binding]; other site 243243001287 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 243243001288 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 243243001289 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 243243001290 DNA repair protein RadA; Provisional; Region: PRK11823 243243001291 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243243001292 Walker A motif; other site 243243001293 ATP binding site [chemical binding]; other site 243243001294 Walker B motif; other site 243243001295 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243243001296 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 243243001297 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 243243001298 substrate binding site; other site 243243001299 dimer interface; other site 243243001300 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 243243001301 homotrimer interaction site [polypeptide binding]; other site 243243001302 zinc binding site [ion binding]; other site 243243001303 CDP-binding sites; other site 243243001304 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 243243001305 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243243001306 active site 243243001307 HIGH motif; other site 243243001308 nucleotide binding site [chemical binding]; other site 243243001309 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243243001310 KMSKS motif; other site 243243001311 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 243243001312 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 243243001313 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 243243001314 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243243001315 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 243243001316 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 243243001317 active site 243243001318 catalytic site [active] 243243001319 metal binding site [ion binding]; metal-binding site 243243001320 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 243243001321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243243001322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243243001323 DNA binding residues [nucleotide binding] 243243001324 dimerization interface [polypeptide binding]; other site 243243001325 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 243243001326 transmembrane helices; other site 243243001327 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 243243001328 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 243243001329 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243243001330 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 243243001331 putative active site [active] 243243001332 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 243243001333 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 243243001334 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 243243001335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243001336 Walker A/P-loop; other site 243243001337 ATP binding site [chemical binding]; other site 243243001338 Q-loop/lid; other site 243243001339 ABC transporter signature motif; other site 243243001340 Walker B; other site 243243001341 D-loop; other site 243243001342 H-loop/switch region; other site 243243001343 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 243243001344 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 243243001345 intersubunit interface [polypeptide binding]; other site 243243001346 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243243001347 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 243243001348 DNA binding site [nucleotide binding] 243243001349 domain linker motif; other site 243243001350 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 243243001351 putative dimerization interface [polypeptide binding]; other site 243243001352 putative ligand binding site [chemical binding]; other site 243243001353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243001354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243001355 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001356 active site 243243001357 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001358 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001359 active site 243243001360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243001361 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 243243001362 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243001363 putative NAD(P) binding site [chemical binding]; other site 243243001364 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 243243001365 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 243243001366 FAD binding pocket [chemical binding]; other site 243243001367 FAD binding motif [chemical binding]; other site 243243001368 phosphate binding motif [ion binding]; other site 243243001369 beta-alpha-beta structure motif; other site 243243001370 NAD(p) ribose binding residues [chemical binding]; other site 243243001371 NAD binding pocket [chemical binding]; other site 243243001372 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 243243001373 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243001374 catalytic loop [active] 243243001375 iron binding site [ion binding]; other site 243243001376 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001377 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 243243001378 Flavin binding site [chemical binding]; other site 243243001379 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 243243001380 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 243243001381 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 243243001382 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 243243001383 active site 243243001384 Fe binding site [ion binding]; other site 243243001385 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 243243001386 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 243243001387 aspartate aminotransferase; Provisional; Region: PRK05764 243243001388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243001389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243001390 homodimer interface [polypeptide binding]; other site 243243001391 catalytic residue [active] 243243001392 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001393 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243001394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001395 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243001396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001397 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001398 active site 243243001399 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001401 active site 243243001402 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 243243001403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243001404 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 243243001405 acyl-activating enzyme (AAE) consensus motif; other site 243243001406 acyl-activating enzyme (AAE) consensus motif; other site 243243001407 putative AMP binding site [chemical binding]; other site 243243001408 putative active site [active] 243243001409 putative CoA binding site [chemical binding]; other site 243243001410 CoA binding site [chemical binding]; other site 243243001411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001413 active site 243243001414 short chain dehydrogenase; Provisional; Region: PRK07831 243243001415 classical (c) SDRs; Region: SDR_c; cd05233 243243001416 NAD(P) binding site [chemical binding]; other site 243243001417 active site 243243001418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243001419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243001420 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 243243001421 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 243243001422 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243001423 dimer interface [polypeptide binding]; other site 243243001424 active site 243243001425 Nitronate monooxygenase; Region: NMO; pfam03060 243243001426 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243001427 FMN binding site [chemical binding]; other site 243243001428 substrate binding site [chemical binding]; other site 243243001429 putative catalytic residue [active] 243243001430 Coenzyme A transferase; Region: CoA_trans; cl17247 243243001431 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 243243001432 enoyl-CoA hydratase; Provisional; Region: PRK06495 243243001433 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243001434 substrate binding site [chemical binding]; other site 243243001435 oxyanion hole (OAH) forming residues; other site 243243001436 trimer interface [polypeptide binding]; other site 243243001437 short chain dehydrogenase; Provisional; Region: PRK07856 243243001438 classical (c) SDRs; Region: SDR_c; cd05233 243243001439 NAD(P) binding site [chemical binding]; other site 243243001440 active site 243243001441 short chain dehydrogenase; Provisional; Region: PRK07791 243243001442 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 243243001443 homodimer interface [polypeptide binding]; other site 243243001444 NAD binding site [chemical binding]; other site 243243001445 active site 243243001446 Domain of unknown function (DUF385); Region: DUF385; pfam04075 243243001447 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 243243001448 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243001449 dimer interface [polypeptide binding]; other site 243243001450 active site 243243001451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243001452 Cytochrome P450; Region: p450; cl12078 243243001453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001454 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243001455 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001457 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001458 active site 243243001459 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 243243001460 active site 243243001461 catalytic site [active] 243243001462 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243001463 active site 2 [active] 243243001464 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 243243001465 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243001466 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 243243001467 putative active site [active] 243243001468 putative catalytic site [active] 243243001469 lipid-transfer protein; Provisional; Region: PRK07855 243243001470 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243001471 active site 243243001472 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 243243001473 putative active site [active] 243243001474 enoyl-CoA hydratase; Region: PLN02864 243243001475 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 243243001476 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 243243001477 dimer interaction site [polypeptide binding]; other site 243243001478 substrate-binding tunnel; other site 243243001479 active site 243243001480 catalytic site [active] 243243001481 substrate binding site [chemical binding]; other site 243243001482 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 243243001483 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 243243001484 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 243243001485 acetaldehyde dehydrogenase; Validated; Region: PRK08300 243243001486 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243243001487 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 243243001488 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 243243001489 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 243243001490 active site 243243001491 catalytic residues [active] 243243001492 metal binding site [ion binding]; metal-binding site 243243001493 DmpG-like communication domain; Region: DmpG_comm; pfam07836 243243001494 short chain dehydrogenase; Provisional; Region: PRK07890 243243001495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243001496 NAD(P) binding site [chemical binding]; other site 243243001497 active site 243243001498 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 243243001499 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243001500 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 243243001501 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 243243001502 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 243243001503 trimer interface [polypeptide binding]; other site 243243001504 putative metal binding site [ion binding]; other site 243243001505 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 243243001506 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 243243001507 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243001508 active site 243243001509 lipid-transfer protein; Provisional; Region: PRK07937 243243001510 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243001511 active site 243243001512 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 243243001513 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243001514 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 243243001515 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243001516 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243001517 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 243243001518 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 243243001519 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243001520 Cytochrome P450; Region: p450; cl12078 243243001521 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 243243001522 putative active site [active] 243243001523 enoyl-CoA hydratase; Provisional; Region: PRK07799 243243001524 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243001525 substrate binding site [chemical binding]; other site 243243001526 oxyanion hole (OAH) forming residues; other site 243243001527 trimer interface [polypeptide binding]; other site 243243001528 acyl-CoA synthetase; Validated; Region: PRK07798 243243001529 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243001530 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 243243001531 acyl-activating enzyme (AAE) consensus motif; other site 243243001532 acyl-activating enzyme (AAE) consensus motif; other site 243243001533 putative AMP binding site [chemical binding]; other site 243243001534 putative active site [active] 243243001535 putative CoA binding site [chemical binding]; other site 243243001536 Fructosamine kinase; Region: Fructosamin_kin; cl17579 243243001537 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 243243001538 hypothetical protein; Validated; Region: PRK07586 243243001539 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243243001540 PYR/PP interface [polypeptide binding]; other site 243243001541 dimer interface [polypeptide binding]; other site 243243001542 TPP binding site [chemical binding]; other site 243243001543 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 243243001544 TPP-binding site [chemical binding]; other site 243243001545 dimer interface [polypeptide binding]; other site 243243001546 acyl-CoA synthetase; Validated; Region: PRK07867 243243001547 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 243243001548 acyl-activating enzyme (AAE) consensus motif; other site 243243001549 putative AMP binding site [chemical binding]; other site 243243001550 putative active site [active] 243243001551 putative CoA binding site [chemical binding]; other site 243243001552 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001553 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243001554 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243243001555 active site 243243001556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001557 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 243243001558 FAD binding site [chemical binding]; other site 243243001559 substrate binding site [chemical binding]; other site 243243001560 catalytic base [active] 243243001561 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243243001562 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 243243001563 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 243243001564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243001565 NAD(P) binding site [chemical binding]; other site 243243001566 active site 243243001567 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243001568 Permease; Region: Permease; pfam02405 243243001569 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243001570 Permease; Region: Permease; pfam02405 243243001571 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243001572 mce related protein; Region: MCE; pfam02470 243243001573 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243001574 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243001575 mce related protein; Region: MCE; pfam02470 243243001576 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243001577 mce related protein; Region: MCE; pfam02470 243243001578 mce related protein; Region: MCE; pfam02470 243243001579 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243001580 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243001581 mce related protein; Region: MCE; pfam02470 243243001582 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 243243001583 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 243243001584 active site 243243001585 homotetramer interface [polypeptide binding]; other site 243243001586 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 243243001587 AAA domain; Region: AAA_23; pfam13476 243243001588 Walker A/P-loop; other site 243243001589 ATP binding site [chemical binding]; other site 243243001590 ABC transporter; Region: ABC_tran; pfam00005 243243001591 Q-loop/lid; other site 243243001592 ABC transporter signature motif; other site 243243001593 Walker B; other site 243243001594 D-loop; other site 243243001595 H-loop/switch region; other site 243243001596 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 243243001597 enoyl-CoA hydratase; Provisional; Region: PRK08290 243243001598 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243001599 substrate binding site [chemical binding]; other site 243243001600 oxyanion hole (OAH) forming residues; other site 243243001601 trimer interface [polypeptide binding]; other site 243243001602 short chain dehydrogenase; Provisional; Region: PRK05875 243243001603 classical (c) SDRs; Region: SDR_c; cd05233 243243001604 NAD(P) binding site [chemical binding]; other site 243243001605 active site 243243001606 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243001607 classical (c) SDRs; Region: SDR_c; cd05233 243243001608 NAD(P) binding site [chemical binding]; other site 243243001609 active site 243243001610 Transcriptional regulator [Transcription]; Region: LytR; COG1316 243243001611 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 243243001612 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 243243001613 Amidase; Region: Amidase; pfam01425 243243001614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243001615 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 243243001616 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 243243001617 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243243001618 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243243001619 catalytic residue [active] 243243001620 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243001621 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243001622 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 243243001623 Helix-turn-helix domain; Region: HTH_17; pfam12728 243243001624 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 243243001625 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243001626 DNA binding site [nucleotide binding] 243243001627 Int/Topo IB signature motif; other site 243243001628 active site 243243001629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243001630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243001631 active site 243243001632 phosphorylation site [posttranslational modification] 243243001633 intermolecular recognition site; other site 243243001634 dimerization interface [polypeptide binding]; other site 243243001635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243001636 DNA binding site [nucleotide binding] 243243001637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243001638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243001639 dimerization interface [polypeptide binding]; other site 243243001640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243001641 dimer interface [polypeptide binding]; other site 243243001642 phosphorylation site [posttranslational modification] 243243001643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243001644 ATP binding site [chemical binding]; other site 243243001645 Mg2+ binding site [ion binding]; other site 243243001646 G-X-G motif; other site 243243001647 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 243243001648 nucleotide binding site/active site [active] 243243001649 HIT family signature motif; other site 243243001650 catalytic residue [active] 243243001651 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 243243001652 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 243243001653 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 243243001654 NAD binding site [chemical binding]; other site 243243001655 catalytic Zn binding site [ion binding]; other site 243243001656 substrate binding site [chemical binding]; other site 243243001657 structural Zn binding site [ion binding]; other site 243243001658 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 243243001659 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 243243001660 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243001661 Cytochrome P450; Region: p450; cl12078 243243001662 short chain dehydrogenase; Provisional; Region: PRK07775 243243001663 classical (c) SDRs; Region: SDR_c; cd05233 243243001664 NAD(P) binding site [chemical binding]; other site 243243001665 active site 243243001666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243001667 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 243243001668 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 243243001669 NAD binding site [chemical binding]; other site 243243001670 catalytic residues [active] 243243001671 short chain dehydrogenase; Provisional; Region: PRK07774 243243001672 classical (c) SDRs; Region: SDR_c; cd05233 243243001673 NAD(P) binding site [chemical binding]; other site 243243001674 active site 243243001675 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243243001676 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243243001677 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 243243001678 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 243243001679 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 243243001680 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 243243001681 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 243243001682 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 243243001683 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 243243001684 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 243243001685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 243243001686 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 243243001687 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 243243001688 adenylosuccinate lyase; Region: purB; TIGR00928 243243001689 tetramer interface [polypeptide binding]; other site 243243001690 active site 243243001691 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243001692 Cytochrome P450; Region: p450; cl12078 243243001693 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 243243001694 ATP binding site [chemical binding]; other site 243243001695 active site 243243001696 substrate binding site [chemical binding]; other site 243243001697 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 243243001698 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243001699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243001700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243001701 WHG domain; Region: WHG; pfam13305 243243001702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243243001703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243001704 putative substrate translocation pore; other site 243243001705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243001706 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243243001707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243001708 putative substrate translocation pore; other site 243243001709 Predicted deacetylase [General function prediction only]; Region: COG3233 243243001710 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 243243001711 putative active site [active] 243243001712 putative Zn binding site [ion binding]; other site 243243001713 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 243243001714 FAD binding domain; Region: FAD_binding_2; pfam00890 243243001715 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 243243001716 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 243243001717 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 243243001718 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 243243001719 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 243243001720 putative active site [active] 243243001721 catalytic triad [active] 243243001722 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243243001723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243001724 DNA-binding site [nucleotide binding]; DNA binding site 243243001725 UTRA domain; Region: UTRA; pfam07702 243243001726 Cupin domain; Region: Cupin_2; cl17218 243243001727 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 243243001728 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 243243001729 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 243243001730 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 243243001731 active site 243243001732 metal binding site [ion binding]; metal-binding site 243243001733 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243243001734 active site 243243001735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243001736 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 243243001737 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 243243001738 dimerization interface [polypeptide binding]; other site 243243001739 ATP binding site [chemical binding]; other site 243243001740 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 243243001741 dimerization interface [polypeptide binding]; other site 243243001742 ATP binding site [chemical binding]; other site 243243001743 amidophosphoribosyltransferase; Provisional; Region: PRK07847 243243001744 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 243243001745 active site 243243001746 tetramer interface [polypeptide binding]; other site 243243001747 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243243001748 active site 243243001749 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 243243001750 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 243243001751 dimerization interface [polypeptide binding]; other site 243243001752 putative ATP binding site [chemical binding]; other site 243243001753 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 243243001754 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 243243001755 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 243243001756 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243243001757 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243243001758 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 243243001759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243001760 catalytic residue [active] 243243001761 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 243243001762 Winged helix-turn helix; Region: HTH_29; pfam13551 243243001763 Integrase core domain; Region: rve; pfam00665 243243001764 Integrase core domain; Region: rve_3; pfam13683 243243001765 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 243243001766 heme-binding site [chemical binding]; other site 243243001767 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 243243001768 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243243001769 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 243243001770 active site residue [active] 243243001771 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 243243001772 active site residue [active] 243243001773 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 243243001774 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243243001775 catalytic residues [active] 243243001776 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 243243001777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243001778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243001779 DNA binding site [nucleotide binding] 243243001780 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 243243001781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243001782 Coenzyme A binding pocket [chemical binding]; other site 243243001783 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 243243001784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243001785 dimer interface [polypeptide binding]; other site 243243001786 conserved gate region; other site 243243001787 putative PBP binding loops; other site 243243001788 ABC-ATPase subunit interface; other site 243243001789 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 243243001790 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 243243001791 Walker A/P-loop; other site 243243001792 ATP binding site [chemical binding]; other site 243243001793 Q-loop/lid; other site 243243001794 ABC transporter signature motif; other site 243243001795 Walker B; other site 243243001796 D-loop; other site 243243001797 H-loop/switch region; other site 243243001798 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 243243001799 PhoU domain; Region: PhoU; pfam01895 243243001800 PhoU domain; Region: PhoU; pfam01895 243243001801 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 243243001802 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 243243001803 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 243243001804 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243243001805 FMN binding site [chemical binding]; other site 243243001806 active site 243243001807 catalytic residues [active] 243243001808 substrate binding site [chemical binding]; other site 243243001809 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 243243001810 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 243243001811 homodimer interface [polypeptide binding]; other site 243243001812 putative substrate binding pocket [chemical binding]; other site 243243001813 diiron center [ion binding]; other site 243243001814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243001815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 243243001816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243243001817 dimerization interface [polypeptide binding]; other site 243243001818 putative DNA binding site [nucleotide binding]; other site 243243001819 putative Zn2+ binding site [ion binding]; other site 243243001820 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243243001821 nucleoside/Zn binding site; other site 243243001822 dimer interface [polypeptide binding]; other site 243243001823 catalytic motif [active] 243243001824 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243001825 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243001826 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243001827 active site 243243001828 DNA binding site [nucleotide binding] 243243001829 Int/Topo IB signature motif; other site 243243001830 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243001831 Cutinase; Region: Cutinase; pfam01083 243243001832 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 243243001833 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 243243001834 active site 243243001835 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243001836 PPE family; Region: PPE; pfam00823 243243001837 flagellar motor protein MotB; Validated; Region: motB; PRK06667 243243001838 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 243243001839 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243243001840 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 243243001841 Protein of unknown function (DUF935); Region: DUF935; pfam06074 243243001842 Phage Terminase; Region: Terminase_1; pfam03354 243243001843 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 243243001844 active site 243243001845 GIY-YIG motif/motif A; other site 243243001846 catalytic site [active] 243243001847 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 243243001848 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 243243001849 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 243243001850 Prophage antirepressor [Transcription]; Region: COG3617 243243001851 BRO family, N-terminal domain; Region: Bro-N; smart01040 243243001852 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 243243001853 Prophage antirepressor [Transcription]; Region: COG3617 243243001854 BRO family, N-terminal domain; Region: Bro-N; smart01040 243243001855 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 243243001856 Helix-turn-helix domain; Region: HTH_17; cl17695 243243001857 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243001858 classical (c) SDRs; Region: SDR_c; cd05233 243243001859 NAD(P) binding site [chemical binding]; other site 243243001860 active site 243243001861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243001862 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 243243001863 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243243001864 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243001865 Cytochrome P450; Region: p450; cl12078 243243001866 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243243001867 DNA-binding site [nucleotide binding]; DNA binding site 243243001868 RNA-binding motif; other site 243243001869 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 243243001870 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243243001871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243001872 S-adenosylmethionine binding site [chemical binding]; other site 243243001873 short chain dehydrogenase; Provisional; Region: PRK08278 243243001874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243001875 NAD(P) binding site [chemical binding]; other site 243243001876 active site 243243001877 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 243243001878 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 243243001879 B12 binding site [chemical binding]; other site 243243001880 cobalt ligand [ion binding]; other site 243243001881 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243001882 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243001883 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243001884 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 243243001885 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243001886 catalytic loop [active] 243243001887 iron binding site [ion binding]; other site 243243001888 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243243001889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243001890 acyl-activating enzyme (AAE) consensus motif; other site 243243001891 AMP binding site [chemical binding]; other site 243243001892 active site 243243001893 CoA binding site [chemical binding]; other site 243243001894 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001895 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001896 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001897 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001898 active site 243243001899 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243001900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243001901 substrate binding site [chemical binding]; other site 243243001902 oxyanion hole (OAH) forming residues; other site 243243001903 trimer interface [polypeptide binding]; other site 243243001904 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 243243001905 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 243243001906 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 243243001907 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243243001908 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243243001909 G4 box; other site 243243001910 G5 box; other site 243243001911 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 243243001912 TPP-binding site [chemical binding]; other site 243243001913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243243001914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243001915 active site 243243001916 phosphorylation site [posttranslational modification] 243243001917 intermolecular recognition site; other site 243243001918 dimerization interface [polypeptide binding]; other site 243243001919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243243001920 DNA binding residues [nucleotide binding] 243243001921 dimerization interface [polypeptide binding]; other site 243243001922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 243243001923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243001924 ATP binding site [chemical binding]; other site 243243001925 Mg2+ binding site [ion binding]; other site 243243001926 G-X-G motif; other site 243243001927 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 243243001928 Predicted oxidoreductase [General function prediction only]; Region: COG3573 243243001929 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243243001930 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243243001931 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243001932 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243001933 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 243243001934 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243001935 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 243243001936 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 243243001937 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 243243001938 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 243243001939 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 243243001940 NAD(P) binding site [chemical binding]; other site 243243001941 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 243243001942 active site 243243001943 Putative cyclase; Region: Cyclase; pfam04199 243243001944 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243001945 TAP-like protein; Region: Abhydrolase_4; pfam08386 243243001946 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 243243001947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243001948 NAD(P) binding site [chemical binding]; other site 243243001949 active site 243243001950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243001951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243001952 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 243243001953 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243001954 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243243001955 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243243001956 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 243243001957 active site 243243001958 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243243001959 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243243001960 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 243243001961 active site 243243001962 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243001963 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243001964 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243001965 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243001966 classical (c) SDRs; Region: SDR_c; cd05233 243243001967 NAD(P) binding site [chemical binding]; other site 243243001968 active site 243243001969 short chain dehydrogenase; Provisional; Region: PRK05876 243243001970 classical (c) SDRs; Region: SDR_c; cd05233 243243001971 NAD(P) binding site [chemical binding]; other site 243243001972 active site 243243001973 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243001974 classical (c) SDRs; Region: SDR_c; cd05233 243243001975 NAD(P) binding site [chemical binding]; other site 243243001976 active site 243243001977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001979 active site 243243001980 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001981 active site 243243001982 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243001983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243001984 active site 243243001985 SnoaL-like domain; Region: SnoaL_4; pfam13577 243243001986 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 243243001987 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243001988 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 243243001989 active site 243243001990 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243001991 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243001992 [2Fe-2S] cluster binding site [ion binding]; other site 243243001993 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 243243001994 alpha subunit interface [polypeptide binding]; other site 243243001995 active site 243243001996 substrate binding site [chemical binding]; other site 243243001997 Fe binding site [ion binding]; other site 243243001998 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243001999 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243002000 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243002001 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 243243002002 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243002003 dimer interface [polypeptide binding]; other site 243243002004 active site 243243002005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002006 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243002007 Cytochrome P450; Region: p450; cl12078 243243002008 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 243243002009 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 243243002010 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 243243002011 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 243243002012 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243002013 Cytochrome P450; Region: p450; cl12078 243243002014 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243243002015 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 243243002016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243002017 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243002018 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243002019 lipid-transfer protein; Provisional; Region: PRK07855 243243002020 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243002021 active site 243243002022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243002023 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243002024 NAD(P) binding site [chemical binding]; other site 243243002025 active site 243243002026 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243002027 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 243243002028 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243002029 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 243243002030 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 243243002031 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243002032 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 243243002033 iron-sulfur cluster [ion binding]; other site 243243002034 [2Fe-2S] cluster binding site [ion binding]; other site 243243002035 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243002036 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243002037 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243243002038 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243243002039 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 243243002040 FMN binding site [chemical binding]; other site 243243002041 dimer interface [polypeptide binding]; other site 243243002042 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243002043 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243002044 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243002045 active site 243243002046 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243002047 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243002048 active site 243243002049 Predicted esterase [General function prediction only]; Region: COG0627 243243002050 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243002051 Cytochrome P450; Region: p450; cl12078 243243002052 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 243243002053 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243002054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243002055 NAD(P) binding site [chemical binding]; other site 243243002056 active site 243243002057 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 243243002058 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 243243002059 NAD binding site [chemical binding]; other site 243243002060 catalytic residues [active] 243243002061 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243002062 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243002063 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243002064 Permease; Region: Permease; pfam02405 243243002065 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243002066 Permease; Region: Permease; pfam02405 243243002067 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243243002068 mce related protein; Region: MCE; pfam02470 243243002069 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243002070 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243002071 mce related protein; Region: MCE; pfam02470 243243002072 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243002073 mce related protein; Region: MCE; pfam02470 243243002074 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243002075 mce related protein; Region: MCE; pfam02470 243243002076 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243002077 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243002078 mce related protein; Region: MCE; pfam02470 243243002079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002081 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 243243002082 Subunit I/III interface [polypeptide binding]; other site 243243002083 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 243243002084 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243002085 Cytochrome P450; Region: p450; cl12078 243243002086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002088 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243002089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002090 substrate binding site [chemical binding]; other site 243243002091 oxyanion hole (OAH) forming residues; other site 243243002092 trimer interface [polypeptide binding]; other site 243243002093 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 243243002094 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243002095 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 243243002096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243002097 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 243243002098 acyl-activating enzyme (AAE) consensus motif; other site 243243002099 acyl-activating enzyme (AAE) consensus motif; other site 243243002100 putative AMP binding site [chemical binding]; other site 243243002101 putative active site [active] 243243002102 putative CoA binding site [chemical binding]; other site 243243002103 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 243243002104 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 243243002105 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 243243002106 dimer interface [polypeptide binding]; other site 243243002107 PYR/PP interface [polypeptide binding]; other site 243243002108 TPP binding site [chemical binding]; other site 243243002109 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243243002110 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 243243002111 TPP-binding site [chemical binding]; other site 243243002112 dimer interface [polypeptide binding]; other site 243243002113 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 243243002114 putative hydrophobic ligand binding site [chemical binding]; other site 243243002115 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243002116 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243002117 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 243243002118 putative hydrophobic ligand binding site [chemical binding]; other site 243243002119 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 243243002120 putative hydrophobic ligand binding site [chemical binding]; other site 243243002121 aminotransferase; Validated; Region: PRK07777 243243002122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243002123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243002124 homodimer interface [polypeptide binding]; other site 243243002125 catalytic residue [active] 243243002126 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 243243002127 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243002128 dimer interface [polypeptide binding]; other site 243243002129 active site 243243002130 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243002131 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002132 substrate binding site [chemical binding]; other site 243243002133 oxyanion hole (OAH) forming residues; other site 243243002134 trimer interface [polypeptide binding]; other site 243243002135 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 243243002136 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243243002137 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243243002138 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 243243002139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243002140 S-adenosylmethionine binding site [chemical binding]; other site 243243002141 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 243243002142 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 243243002143 hypothetical protein; Provisional; Region: PRK07588 243243002144 hypothetical protein; Provisional; Region: PRK07236 243243002145 hypothetical protein; Provisional; Region: PRK07236 243243002146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002148 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243002149 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 243243002150 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 243243002151 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243002152 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243002153 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 243243002154 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243002155 active site 243243002156 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 243243002157 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 243243002158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243002159 ATP binding site [chemical binding]; other site 243243002160 putative Mg++ binding site [ion binding]; other site 243243002161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243002162 nucleotide binding region [chemical binding]; other site 243243002163 ATP-binding site [chemical binding]; other site 243243002164 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 243243002165 WYL domain; Region: WYL; pfam13280 243243002166 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 243243002167 trimer interface [polypeptide binding]; other site 243243002168 dimer interface [polypeptide binding]; other site 243243002169 putative active site [active] 243243002170 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 243243002171 MPT binding site; other site 243243002172 trimer interface [polypeptide binding]; other site 243243002173 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 243243002174 MoaE homodimer interface [polypeptide binding]; other site 243243002175 MoaD interaction [polypeptide binding]; other site 243243002176 active site residues [active] 243243002177 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 243243002178 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 243243002179 MoaE interaction surface [polypeptide binding]; other site 243243002180 MoeB interaction surface [polypeptide binding]; other site 243243002181 thiocarboxylated glycine; other site 243243002182 hypothetical protein; Provisional; Region: PRK11770 243243002183 Domain of unknown function (DUF307); Region: DUF307; pfam03733 243243002184 Domain of unknown function (DUF307); Region: DUF307; pfam03733 243243002185 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243243002186 DNA-binding site [nucleotide binding]; DNA binding site 243243002187 RNA-binding motif; other site 243243002188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243002189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243002190 active site 243243002191 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 243243002192 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243243002193 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 243243002194 putative dimer interface [polypeptide binding]; other site 243243002195 N-terminal domain interface [polypeptide binding]; other site 243243002196 putative substrate binding pocket (H-site) [chemical binding]; other site 243243002197 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 243243002198 putative active site [active] 243243002199 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 243243002200 H+ Antiporter protein; Region: 2A0121; TIGR00900 243243002201 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 243243002202 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 243243002203 hydrophobic ligand binding site; other site 243243002204 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 243243002205 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243002206 MarR family; Region: MarR; pfam01047 243243002207 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 243243002208 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243243002209 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 243243002210 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 243243002211 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243002212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243002213 catalytic residue [active] 243243002214 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 243243002215 Ferredoxin [Energy production and conversion]; Region: COG1146 243243002216 4Fe-4S binding domain; Region: Fer4; pfam00037 243243002217 ferredoxin-NADP+ reductase; Region: PLN02852 243243002218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243002219 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 243243002220 putative dimer interface [polypeptide binding]; other site 243243002221 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243002222 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 243243002223 dimer interface [polypeptide binding]; other site 243243002224 Citrate synthase; Region: Citrate_synt; pfam00285 243243002225 active site 243243002226 citrylCoA binding site [chemical binding]; other site 243243002227 oxalacetate/citrate binding site [chemical binding]; other site 243243002228 coenzyme A binding site [chemical binding]; other site 243243002229 catalytic triad [active] 243243002230 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 243243002231 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243243002232 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 243243002233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 243243002234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243002235 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 243243002236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243002237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243002238 dimer interface [polypeptide binding]; other site 243243002239 phosphorylation site [posttranslational modification] 243243002240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243002241 ATP binding site [chemical binding]; other site 243243002242 Mg2+ binding site [ion binding]; other site 243243002243 G-X-G motif; other site 243243002244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243002245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243002246 active site 243243002247 phosphorylation site [posttranslational modification] 243243002248 intermolecular recognition site; other site 243243002249 dimerization interface [polypeptide binding]; other site 243243002250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243002251 DNA binding site [nucleotide binding] 243243002252 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 243243002253 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 243243002254 putative ADP-binding pocket [chemical binding]; other site 243243002255 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 243243002256 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 243243002257 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243002258 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002259 substrate binding site [chemical binding]; other site 243243002260 oxyanion hole (OAH) forming residues; other site 243243002261 trimer interface [polypeptide binding]; other site 243243002262 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 243243002263 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 243243002264 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243243002265 Beta-lactamase; Region: Beta-lactamase; pfam00144 243243002266 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 243243002267 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243243002268 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 243243002269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243002270 motif II; other site 243243002271 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 243243002272 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 243243002273 hydrophobic ligand binding site; other site 243243002274 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 243243002275 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 243243002276 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243002277 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 243243002278 putative active site pocket [active] 243243002279 dimerization interface [polypeptide binding]; other site 243243002280 putative catalytic residue [active] 243243002281 Protein of unknown function (DUF867); Region: DUF867; pfam05908 243243002282 manganese transport protein MntH; Reviewed; Region: PRK00701 243243002283 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243243002284 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243002285 short chain dehydrogenase; Provisional; Region: PRK07814 243243002286 classical (c) SDRs; Region: SDR_c; cd05233 243243002287 NAD(P) binding site [chemical binding]; other site 243243002288 active site 243243002289 PBP superfamily domain; Region: PBP_like_2; cl17296 243243002290 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 243243002291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243002292 dimer interface [polypeptide binding]; other site 243243002293 conserved gate region; other site 243243002294 putative PBP binding loops; other site 243243002295 ABC-ATPase subunit interface; other site 243243002296 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 243243002297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243002298 dimer interface [polypeptide binding]; other site 243243002299 conserved gate region; other site 243243002300 putative PBP binding loops; other site 243243002301 ABC-ATPase subunit interface; other site 243243002302 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 243243002303 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 243243002304 putative DNA binding site [nucleotide binding]; other site 243243002305 putative homodimer interface [polypeptide binding]; other site 243243002306 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243243002307 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 243243002308 putative substrate binding site [chemical binding]; other site 243243002309 putative ATP binding site [chemical binding]; other site 243243002310 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 243243002311 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 243243002312 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 243243002313 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243243002314 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 243243002315 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 243243002316 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 243243002317 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 243243002318 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 243243002319 nucleotide binding site [chemical binding]; other site 243243002320 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 243243002321 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 243243002322 active site 243243002323 DNA binding site [nucleotide binding] 243243002324 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 243243002325 DNA binding site [nucleotide binding] 243243002326 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243243002327 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243243002328 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243002329 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243002330 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243002331 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243243002332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243243002333 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243243002334 enoyl-CoA hydratase; Provisional; Region: PRK08260 243243002335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002336 substrate binding site [chemical binding]; other site 243243002337 oxyanion hole (OAH) forming residues; other site 243243002338 trimer interface [polypeptide binding]; other site 243243002339 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243002340 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243002341 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243002342 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243002343 anti sigma factor interaction site; other site 243243002344 regulatory phosphorylation site [posttranslational modification]; other site 243243002345 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 243243002346 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 243243002347 active site 243243002348 SAM binding site [chemical binding]; other site 243243002349 homodimer interface [polypeptide binding]; other site 243243002350 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 243243002351 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 243243002352 putative DNA binding site [nucleotide binding]; other site 243243002353 catalytic residue [active] 243243002354 putative H2TH interface [polypeptide binding]; other site 243243002355 putative catalytic residues [active] 243243002356 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243243002357 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243243002358 short chain dehydrogenase; Provisional; Region: PRK08251 243243002359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243002360 NAD(P) binding site [chemical binding]; other site 243243002361 active site 243243002362 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 243243002363 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 243243002364 active site 243243002365 dimer interface [polypeptide binding]; other site 243243002366 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 243243002367 dimer interface [polypeptide binding]; other site 243243002368 active site 243243002369 hypothetical protein; Provisional; Region: PRK07857 243243002370 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 243243002371 Part of AAA domain; Region: AAA_19; pfam13245 243243002372 Family description; Region: UvrD_C_2; pfam13538 243243002373 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 243243002374 Peptidase family M23; Region: Peptidase_M23; pfam01551 243243002375 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 243243002376 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 243243002377 CoA-ligase; Region: Ligase_CoA; pfam00549 243243002378 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 243243002379 CoA binding domain; Region: CoA_binding; smart00881 243243002380 CoA-ligase; Region: Ligase_CoA; pfam00549 243243002381 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 243243002382 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243002383 active site 243243002384 Omptin family; Region: Omptin; cl01886 243243002385 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243002386 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243002387 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 243243002388 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 243243002389 active site 243243002390 cosubstrate binding site; other site 243243002391 substrate binding site [chemical binding]; other site 243243002392 catalytic site [active] 243243002393 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 243243002394 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 243243002395 purine monophosphate binding site [chemical binding]; other site 243243002396 dimer interface [polypeptide binding]; other site 243243002397 putative catalytic residues [active] 243243002398 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 243243002399 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 243243002400 LGFP repeat; Region: LGFP; pfam08310 243243002401 LGFP repeat; Region: LGFP; pfam08310 243243002402 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 243243002403 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243243002404 metal ion-dependent adhesion site (MIDAS); other site 243243002405 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243002406 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243002407 active site 243243002408 catalytic tetrad [active] 243243002409 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 243243002410 enoyl-CoA hydratase; Provisional; Region: PRK07827 243243002411 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002412 substrate binding site [chemical binding]; other site 243243002413 oxyanion hole (OAH) forming residues; other site 243243002414 trimer interface [polypeptide binding]; other site 243243002415 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243002416 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243243002417 active site 243243002418 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 243243002419 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243243002420 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243243002421 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243243002422 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243243002423 carboxyltransferase (CT) interaction site; other site 243243002424 biotinylation site [posttranslational modification]; other site 243243002425 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 243243002426 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 243243002427 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 243243002428 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243002429 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243002430 active site 243243002431 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 243243002432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243002433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243002434 active site 243243002435 phosphorylation site [posttranslational modification] 243243002436 intermolecular recognition site; other site 243243002437 dimerization interface [polypeptide binding]; other site 243243002438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243002439 DNA binding site [nucleotide binding] 243243002440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243002441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243002442 dimerization interface [polypeptide binding]; other site 243243002443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243002444 dimer interface [polypeptide binding]; other site 243243002445 phosphorylation site [posttranslational modification] 243243002446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243002447 ATP binding site [chemical binding]; other site 243243002448 Mg2+ binding site [ion binding]; other site 243243002449 G-X-G motif; other site 243243002450 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243243002451 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243243002452 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243243002453 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 243243002454 MPT binding site; other site 243243002455 trimer interface [polypeptide binding]; other site 243243002456 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 243243002457 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 243243002458 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 243243002459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 243243002460 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 243243002461 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 243243002462 active site 243243002463 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 243243002464 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 243243002465 dimer interface [polypeptide binding]; other site 243243002466 putative functional site; other site 243243002467 putative MPT binding site; other site 243243002468 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 243243002469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243243002470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002472 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243002473 CoenzymeA binding site [chemical binding]; other site 243243002474 subunit interaction site [polypeptide binding]; other site 243243002475 PHB binding site; other site 243243002476 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 243243002477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002478 DNA-binding interface [nucleotide binding]; DNA binding site 243243002479 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243002480 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243002481 [2Fe-2S] cluster binding site [ion binding]; other site 243243002482 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 243243002483 putative alpha subunit interface [polypeptide binding]; other site 243243002484 putative active site [active] 243243002485 putative substrate binding site [chemical binding]; other site 243243002486 Fe binding site [ion binding]; other site 243243002487 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 243243002488 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 243243002489 metal binding site [ion binding]; metal-binding site 243243002490 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 243243002491 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243243002492 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 243243002493 active site 243243002494 dimer interface [polypeptide binding]; other site 243243002495 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 243243002496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243002497 active site 243243002498 motif I; other site 243243002499 motif II; other site 243243002500 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243243002501 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243243002502 ligand binding site [chemical binding]; other site 243243002503 flexible hinge region; other site 243243002504 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243243002505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243002506 Coenzyme A binding pocket [chemical binding]; other site 243243002507 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 243243002508 arginine deiminase; Provisional; Region: PRK01388 243243002509 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243243002510 Predicted methyltransferases [General function prediction only]; Region: COG0313 243243002511 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 243243002512 putative SAM binding site [chemical binding]; other site 243243002513 putative homodimer interface [polypeptide binding]; other site 243243002514 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 243243002515 chorismate binding enzyme; Region: Chorismate_bind; cl10555 243243002516 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 243243002517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243002518 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243243002519 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243002520 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243243002521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243002522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243002523 GAF domain; Region: GAF; cl17456 243243002524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243243002525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243243002526 metal binding site [ion binding]; metal-binding site 243243002527 active site 243243002528 I-site; other site 243243002529 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243243002530 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 243243002531 Chain length determinant protein; Region: Wzz; pfam02706 243243002532 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 243243002533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243002534 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243243002535 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 243243002536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243002537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002541 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243243002542 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243243002543 putative active site [active] 243243002544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243243002545 PAS domain; Region: PAS_9; pfam13426 243243002546 putative active site [active] 243243002547 heme pocket [chemical binding]; other site 243243002548 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 243243002549 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 243243002550 active site 243243002551 HIGH motif; other site 243243002552 KMSKS motif; other site 243243002553 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 243243002554 tRNA binding surface [nucleotide binding]; other site 243243002555 anticodon binding site; other site 243243002556 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243243002557 active site 243243002558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 243243002559 Domain of unknown function (DUF348); Region: DUF348; pfam03990 243243002560 Domain of unknown function (DUF348); Region: DUF348; pfam03990 243243002561 G5 domain; Region: G5; pfam07501 243243002562 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 243243002563 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 243243002564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243002565 S-adenosylmethionine binding site [chemical binding]; other site 243243002566 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 243243002567 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 243243002568 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243243002569 acyl-activating enzyme (AAE) consensus motif; other site 243243002570 active site 243243002571 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 243243002572 putative active site [active] 243243002573 catalytic residue [active] 243243002574 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 243243002575 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 243243002576 5S rRNA interface [nucleotide binding]; other site 243243002577 CTC domain interface [polypeptide binding]; other site 243243002578 L16 interface [polypeptide binding]; other site 243243002579 short chain dehydrogenase; Provisional; Region: PRK06197 243243002580 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 243243002581 putative NAD(P) binding site [chemical binding]; other site 243243002582 active site 243243002583 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 243243002584 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 243243002585 ArsC family; Region: ArsC; pfam03960 243243002586 catalytic residues [active] 243243002587 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 243243002588 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 243243002589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243243002590 active site 243243002591 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 243243002592 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 243243002593 Substrate binding site; other site 243243002594 Mg++ binding site; other site 243243002595 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 243243002596 active site 243243002597 substrate binding site [chemical binding]; other site 243243002598 CoA binding site [chemical binding]; other site 243243002599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002601 diaminopimelate decarboxylase; Region: lysA; TIGR01048 243243002602 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 243243002603 active site 243243002604 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243243002605 substrate binding site [chemical binding]; other site 243243002606 catalytic residues [active] 243243002607 dimer interface [polypeptide binding]; other site 243243002608 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 243243002609 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 243243002610 homodimer interface [polypeptide binding]; other site 243243002611 metal binding site [ion binding]; metal-binding site 243243002612 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 243243002613 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243243002614 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243243002615 enolase; Provisional; Region: eno; PRK00077 243243002616 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243243002617 dimer interface [polypeptide binding]; other site 243243002618 metal binding site [ion binding]; metal-binding site 243243002619 substrate binding pocket [chemical binding]; other site 243243002620 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 243243002621 Septum formation initiator; Region: DivIC; pfam04977 243243002622 Uncharacterized conserved protein [Function unknown]; Region: COG1507 243243002623 exopolyphosphatase; Region: exo_poly_only; TIGR03706 243243002624 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 243243002625 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 243243002626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243002627 active site 243243002628 phosphorylation site [posttranslational modification] 243243002629 intermolecular recognition site; other site 243243002630 dimerization interface [polypeptide binding]; other site 243243002631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243002632 DNA binding site [nucleotide binding] 243243002633 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 243243002634 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 243243002635 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 243243002636 Ligand Binding Site [chemical binding]; other site 243243002637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243002638 dimer interface [polypeptide binding]; other site 243243002639 phosphorylation site [posttranslational modification] 243243002640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243002641 ATP binding site [chemical binding]; other site 243243002642 Mg2+ binding site [ion binding]; other site 243243002643 G-X-G motif; other site 243243002644 K+-transporting ATPase, c chain; Region: KdpC; cl00944 243243002645 K+-transporting ATPase, c chain; Region: KdpC; cl00944 243243002646 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 243243002647 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243243002648 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243243002649 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 243243002650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243002651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243002652 dimer interface [polypeptide binding]; other site 243243002653 phosphorylation site [posttranslational modification] 243243002654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243002655 ATP binding site [chemical binding]; other site 243243002656 Mg2+ binding site [ion binding]; other site 243243002657 G-X-G motif; other site 243243002658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243002659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243002660 active site 243243002661 phosphorylation site [posttranslational modification] 243243002662 intermolecular recognition site; other site 243243002663 dimerization interface [polypeptide binding]; other site 243243002664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243002665 DNA binding site [nucleotide binding] 243243002666 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 243243002667 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 243243002668 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243243002669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243002670 S-adenosylmethionine binding site [chemical binding]; other site 243243002671 Domain of unknown function (DUF427); Region: DUF427; cl00998 243243002672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 243243002673 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243243002674 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243243002675 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243243002676 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 243243002677 dimer interface [polypeptide binding]; other site 243243002678 acyl-activating enzyme (AAE) consensus motif; other site 243243002679 putative active site [active] 243243002680 AMP binding site [chemical binding]; other site 243243002681 putative CoA binding site [chemical binding]; other site 243243002682 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 243243002683 putative hydrophobic ligand binding site [chemical binding]; other site 243243002684 protein interface [polypeptide binding]; other site 243243002685 gate; other site 243243002686 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 243243002687 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 243243002688 putative active site [active] 243243002689 putative dimer interface [polypeptide binding]; other site 243243002690 Patatin-like phospholipase; Region: Patatin; pfam01734 243243002691 nucleophile elbow; other site 243243002692 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243243002693 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 243243002694 active site 243243002695 nucleophile elbow; other site 243243002696 anthranilate synthase component I-like protein; Validated; Region: PRK05940 243243002697 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 243243002698 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243243002699 active site residue [active] 243243002700 Predicted membrane protein [Function unknown]; Region: COG4425 243243002701 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 243243002702 enoyl-CoA hydratase; Provisional; Region: PRK05862 243243002703 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002704 substrate binding site [chemical binding]; other site 243243002705 oxyanion hole (OAH) forming residues; other site 243243002706 trimer interface [polypeptide binding]; other site 243243002707 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 243243002708 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002709 substrate binding site [chemical binding]; other site 243243002710 oxyanion hole (OAH) forming residues; other site 243243002711 trimer interface [polypeptide binding]; other site 243243002712 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 243243002713 Bax inhibitor 1 like; Region: BaxI_1; cl17691 243243002714 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 243243002715 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243002716 dimer interface [polypeptide binding]; other site 243243002717 active site 243243002718 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 243243002719 active site 243243002720 catalytic triad [active] 243243002721 oxyanion hole [active] 243243002722 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243002723 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243002724 substrate binding pocket [chemical binding]; other site 243243002725 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 243243002726 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243243002727 dimer interface [polypeptide binding]; other site 243243002728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243002729 catalytic residue [active] 243243002730 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 243243002731 RDD family; Region: RDD; pfam06271 243243002732 cystathionine gamma-synthase; Provisional; Region: PRK07811 243243002733 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243243002734 homodimer interface [polypeptide binding]; other site 243243002735 substrate-cofactor binding pocket; other site 243243002736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243002737 catalytic residue [active] 243243002738 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 243243002739 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243243002740 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243243002741 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 243243002742 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 243243002743 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 243243002744 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 243243002745 catalytic residues [active] 243243002746 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 243243002747 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 243243002748 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 243243002749 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 243243002750 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 243243002751 catalytic residue [active] 243243002752 putative FPP diphosphate binding site; other site 243243002753 putative FPP binding hydrophobic cleft; other site 243243002754 dimer interface [polypeptide binding]; other site 243243002755 putative IPP diphosphate binding site; other site 243243002756 pantothenate kinase; Provisional; Region: PRK05439 243243002757 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 243243002758 ATP-binding site [chemical binding]; other site 243243002759 CoA-binding site [chemical binding]; other site 243243002760 Mg2+-binding site [ion binding]; other site 243243002761 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 243243002762 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 243243002763 dimer interface [polypeptide binding]; other site 243243002764 active site 243243002765 glycine-pyridoxal phosphate binding site [chemical binding]; other site 243243002766 folate binding site [chemical binding]; other site 243243002767 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 243243002768 dinuclear metal binding motif [ion binding]; other site 243243002769 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 243243002770 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 243243002771 putative active site [active] 243243002772 PhoH-like protein; Region: PhoH; pfam02562 243243002773 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243243002774 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 243243002775 NodB motif; other site 243243002776 active site 243243002777 catalytic site [active] 243243002778 metal binding site [ion binding]; metal-binding site 243243002779 HAMP domain; Region: HAMP; pfam00672 243243002780 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 243243002781 cyclase homology domain; Region: CHD; cd07302 243243002782 nucleotidyl binding site; other site 243243002783 metal binding site [ion binding]; metal-binding site 243243002784 dimer interface [polypeptide binding]; other site 243243002785 fumarate hydratase; Reviewed; Region: fumC; PRK00485 243243002786 Class II fumarases; Region: Fumarase_classII; cd01362 243243002787 active site 243243002788 tetramer interface [polypeptide binding]; other site 243243002789 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 243243002790 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 243243002791 putative active site [active] 243243002792 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 243243002793 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243243002794 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 243243002795 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243002796 substrate binding pocket [chemical binding]; other site 243243002797 catalytic triad [active] 243243002798 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 243243002799 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 243243002800 putative NAD(P) binding site [chemical binding]; other site 243243002801 active site 243243002802 putative substrate binding site [chemical binding]; other site 243243002803 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 243243002804 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 243243002805 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 243243002806 generic binding surface I; other site 243243002807 generic binding surface II; other site 243243002808 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 243243002809 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 243243002810 GTP-binding protein YchF; Reviewed; Region: PRK09601 243243002811 YchF GTPase; Region: YchF; cd01900 243243002812 G1 box; other site 243243002813 GTP/Mg2+ binding site [chemical binding]; other site 243243002814 Switch I region; other site 243243002815 G2 box; other site 243243002816 Switch II region; other site 243243002817 G3 box; other site 243243002818 G4 box; other site 243243002819 G5 box; other site 243243002820 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 243243002821 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243002822 MULE transposase domain; Region: MULE; pfam10551 243243002823 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243002824 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 243243002825 active site 243243002826 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243002827 MULE transposase domain; Region: MULE; pfam10551 243243002828 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243002829 MULE transposase domain; Region: MULE; pfam10551 243243002830 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 243243002831 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 243243002832 Domain of unknown function (DUF385); Region: DUF385; pfam04075 243243002833 short chain dehydrogenase; Provisional; Region: PRK06500 243243002834 classical (c) SDRs; Region: SDR_c; cd05233 243243002835 NAD(P) binding site [chemical binding]; other site 243243002836 active site 243243002837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002839 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243002840 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243243002841 active site 243243002842 metal binding site [ion binding]; metal-binding site 243243002843 Uncharacterized conserved protein [Function unknown]; Region: COG1359 243243002844 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243243002845 cyclase homology domain; Region: CHD; cd07302 243243002846 nucleotidyl binding site; other site 243243002847 metal binding site [ion binding]; metal-binding site 243243002848 dimer interface [polypeptide binding]; other site 243243002849 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 243243002850 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 243243002851 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 243243002852 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 243243002853 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243243002854 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243002855 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243002856 TAP-like protein; Region: Abhydrolase_4; pfam08386 243243002857 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 243243002858 dimer interface [polypeptide binding]; other site 243243002859 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243002860 FeoC like transcriptional regulator; Region: FeoC; cl17677 243243002861 pyruvate phosphate dikinase; Provisional; Region: PRK05878 243243002862 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243243002863 Predicted membrane protein [Function unknown]; Region: COG2259 243243002864 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 243243002865 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 243243002866 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 243243002867 THF binding site; other site 243243002868 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 243243002869 substrate binding site [chemical binding]; other site 243243002870 THF binding site; other site 243243002871 zinc-binding site [ion binding]; other site 243243002872 NADH(P)-binding; Region: NAD_binding_10; pfam13460 243243002873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243002874 NAD(P) binding site [chemical binding]; other site 243243002875 active site 243243002876 short chain dehydrogenase; Provisional; Region: PRK12829 243243002877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243002878 NAD(P) binding site [chemical binding]; other site 243243002879 active site 243243002880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243002883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243002884 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 243243002885 FMN binding site [chemical binding]; other site 243243002886 dimer interface [polypeptide binding]; other site 243243002887 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243002888 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243002889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243002890 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243002891 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243002892 active site 243243002893 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243243002894 metal ion-dependent adhesion site (MIDAS); other site 243243002895 MoxR-like ATPases [General function prediction only]; Region: COG0714 243243002896 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 243243002897 Walker A motif; other site 243243002898 ATP binding site [chemical binding]; other site 243243002899 Walker B motif; other site 243243002900 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 243243002901 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 243243002902 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 243243002903 ligand binding site [chemical binding]; other site 243243002904 short chain dehydrogenase; Provisional; Region: PRK06179 243243002905 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 243243002906 NADP binding site [chemical binding]; other site 243243002907 active site 243243002908 steroid binding site; other site 243243002909 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243002910 Cytochrome P450; Region: p450; cl12078 243243002911 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 243243002912 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 243243002913 NAD binding site [chemical binding]; other site 243243002914 catalytic residues [active] 243243002915 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 243243002916 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243002917 dimer interface [polypeptide binding]; other site 243243002918 active site 243243002919 enoyl-CoA hydratase; Provisional; Region: PRK08252 243243002920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002921 substrate binding site [chemical binding]; other site 243243002922 oxyanion hole (OAH) forming residues; other site 243243002923 trimer interface [polypeptide binding]; other site 243243002924 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 243243002925 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243002926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 243243002927 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 243243002928 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 243243002929 malonyl-CoA binding site [chemical binding]; other site 243243002930 dimer interface [polypeptide binding]; other site 243243002931 active site 243243002932 product binding site; other site 243243002933 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 243243002934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243002935 NAD(P) binding site [chemical binding]; other site 243243002936 active site 243243002937 CAAX protease self-immunity; Region: Abi; pfam02517 243243002938 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243002939 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243002940 substrate binding site [chemical binding]; other site 243243002941 oxyanion hole (OAH) forming residues; other site 243243002942 trimer interface [polypeptide binding]; other site 243243002943 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243002944 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243002945 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 243243002946 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 243243002947 NAD binding site [chemical binding]; other site 243243002948 homodimer interface [polypeptide binding]; other site 243243002949 homotetramer interface [polypeptide binding]; other site 243243002950 active site 243243002951 MMPL family; Region: MMPL; pfam03176 243243002952 MMPL family; Region: MMPL; pfam03176 243243002953 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243243002954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243002955 S-adenosylmethionine binding site [chemical binding]; other site 243243002956 NAD-dependent deacetylase; Provisional; Region: PRK00481 243243002957 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 243243002958 NAD+ binding site [chemical binding]; other site 243243002959 substrate binding site [chemical binding]; other site 243243002960 Zn binding site [ion binding]; other site 243243002961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243002962 DNA-binding site [nucleotide binding]; DNA binding site 243243002963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 243243002964 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 243243002965 uncharacterized HhH-GPD family protein; Region: TIGR03252 243243002966 minor groove reading motif; other site 243243002967 helix-hairpin-helix signature motif; other site 243243002968 mannosyltransferase; Provisional; Region: pimE; PRK13375 243243002969 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 243243002970 aromatic arch; other site 243243002971 DCoH dimer interaction site [polypeptide binding]; other site 243243002972 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 243243002973 DCoH tetramer interaction site [polypeptide binding]; other site 243243002974 substrate binding site [chemical binding]; other site 243243002975 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 243243002976 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 243243002977 active site 243243002978 8-oxo-dGMP binding site [chemical binding]; other site 243243002979 nudix motif; other site 243243002980 metal binding site [ion binding]; metal-binding site 243243002981 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 243243002982 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 243243002983 [4Fe-4S] binding site [ion binding]; other site 243243002984 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243002985 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243002986 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243002987 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 243243002988 molybdopterin cofactor binding site; other site 243243002989 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 243243002990 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 243243002991 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 243243002992 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 243243002993 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 243243002994 G1 box; other site 243243002995 putative GEF interaction site [polypeptide binding]; other site 243243002996 GTP/Mg2+ binding site [chemical binding]; other site 243243002997 Switch I region; other site 243243002998 G2 box; other site 243243002999 G3 box; other site 243243003000 Switch II region; other site 243243003001 G4 box; other site 243243003002 G5 box; other site 243243003003 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 243243003004 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 243243003005 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 243243003006 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 243243003007 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 243243003008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243003009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243003010 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 243243003011 FO synthase; Reviewed; Region: fbiC; PRK09234 243243003012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243243003013 FeS/SAM binding site; other site 243243003014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243243003015 FeS/SAM binding site; other site 243243003016 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 243243003017 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 243243003018 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 243243003019 4Fe-4S binding domain; Region: Fer4; pfam00037 243243003020 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 243243003021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243003022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243003023 homodimer interface [polypeptide binding]; other site 243243003024 catalytic residue [active] 243243003025 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243243003026 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 243243003027 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 243243003028 generic binding surface II; other site 243243003029 ssDNA binding site; other site 243243003030 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243003031 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243243003032 active site 243243003033 Acyl transferase domain; Region: Acyl_transf_1; cl08282 243243003034 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243243003035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243003036 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243243003037 Enoylreductase; Region: PKS_ER; smart00829 243243003038 NAD(P) binding site [chemical binding]; other site 243243003039 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 243243003040 KR domain; Region: KR; pfam08659 243243003041 putative NADP binding site [chemical binding]; other site 243243003042 active site 243243003043 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243003044 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 243243003045 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243003046 PPE family; Region: PPE; pfam00823 243243003047 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243003048 PPE family; Region: PPE; pfam00823 243243003049 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243243003050 ligand-binding site [chemical binding]; other site 243243003051 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 243243003052 ATP-sulfurylase; Region: ATPS; cd00517 243243003053 active site 243243003054 HXXH motif; other site 243243003055 flexible loop; other site 243243003056 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243243003057 acyl-CoA synthetase; Validated; Region: PRK05850 243243003058 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243243003059 acyl-activating enzyme (AAE) consensus motif; other site 243243003060 active site 243243003061 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243003062 PPE family; Region: PPE; pfam00823 243243003063 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 243243003064 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 243243003065 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243243003066 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 243243003067 NAD(P) binding site [chemical binding]; other site 243243003068 catalytic residues [active] 243243003069 Proline dehydrogenase; Region: Pro_dh; cl03282 243243003070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243003071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243003072 lipid-transfer protein; Provisional; Region: PRK07855 243243003073 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243003074 active site 243243003075 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 243243003076 putative active site [active] 243243003077 putative catalytic site [active] 243243003078 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003079 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243003080 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243243003081 active site 243243003082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003084 active site 243243003085 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243003086 Cytochrome P450; Region: p450; cl12078 243243003087 Cytochrome P450; Region: p450; cl12078 243243003088 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243003089 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 243243003090 NAD binding site [chemical binding]; other site 243243003091 catalytic residues [active] 243243003092 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243003093 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243003094 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243003095 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243003096 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243003097 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 243243003098 acyl-CoA synthetase; Validated; Region: PRK07787 243243003099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003100 acyl-activating enzyme (AAE) consensus motif; other site 243243003101 AMP binding site [chemical binding]; other site 243243003102 active site 243243003103 CoA binding site [chemical binding]; other site 243243003104 metabolite-proton symporter; Region: 2A0106; TIGR00883 243243003105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243003106 putative substrate translocation pore; other site 243243003107 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 243243003108 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 243243003109 putative trimer interface [polypeptide binding]; other site 243243003110 putative CoA binding site [chemical binding]; other site 243243003111 PE family; Region: PE; pfam00934 243243003112 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243003113 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243003114 PPE family; Region: PPE; pfam00823 243243003115 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243003116 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 243243003117 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 243243003118 metal binding site [ion binding]; metal-binding site 243243003119 putative dimer interface [polypeptide binding]; other site 243243003120 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 243243003121 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 243243003122 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 243243003123 acyl-activating enzyme (AAE) consensus motif; other site 243243003124 putative AMP binding site [chemical binding]; other site 243243003125 putative active site [active] 243243003126 putative CoA binding site [chemical binding]; other site 243243003127 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 243243003128 dihydropteroate synthase; Region: DHPS; TIGR01496 243243003129 substrate binding pocket [chemical binding]; other site 243243003130 dimer interface [polypeptide binding]; other site 243243003131 inhibitor binding site; inhibition site 243243003132 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243243003133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243243003134 active site 243243003135 DivIVA domain; Region: DivI1A_domain; TIGR03544 243243003136 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 243243003137 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 243243003138 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 243243003139 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243243003140 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 243243003141 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 243243003142 ligand binding site; other site 243243003143 oligomer interface; other site 243243003144 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 243243003145 dimer interface [polypeptide binding]; other site 243243003146 N-terminal domain interface [polypeptide binding]; other site 243243003147 sulfate 1 binding site; other site 243243003148 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 243243003149 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 243243003150 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 243243003151 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 243243003152 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 243243003153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243243003154 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243243003155 Walker A/P-loop; other site 243243003156 ATP binding site [chemical binding]; other site 243243003157 Q-loop/lid; other site 243243003158 ABC transporter signature motif; other site 243243003159 Walker B; other site 243243003160 D-loop; other site 243243003161 H-loop/switch region; other site 243243003162 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 243243003163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243003164 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 243243003165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243003166 S-adenosylmethionine binding site [chemical binding]; other site 243243003167 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 243243003168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243003169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243003170 DNA binding residues [nucleotide binding] 243243003171 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243243003172 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243243003173 protein binding site [polypeptide binding]; other site 243243003174 sec-independent translocase; Provisional; Region: PRK03100 243243003175 Domain of unknown function DUF59; Region: DUF59; cl00941 243243003176 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 243243003177 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 243243003178 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243243003179 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243243003180 catalytic residue [active] 243243003181 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 243243003182 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 243243003183 MgtE intracellular N domain; Region: MgtE_N; smart00924 243243003184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 243243003185 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 243243003186 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 243243003187 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 243243003188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243003189 dimer interface [polypeptide binding]; other site 243243003190 conserved gate region; other site 243243003191 putative PBP binding loops; other site 243243003192 ABC-ATPase subunit interface; other site 243243003193 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 243243003194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243003195 dimer interface [polypeptide binding]; other site 243243003196 conserved gate region; other site 243243003197 ABC-ATPase subunit interface; other site 243243003198 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 243243003199 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 243243003200 Walker A/P-loop; other site 243243003201 ATP binding site [chemical binding]; other site 243243003202 Q-loop/lid; other site 243243003203 ABC transporter signature motif; other site 243243003204 Walker B; other site 243243003205 D-loop; other site 243243003206 H-loop/switch region; other site 243243003207 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 243243003208 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 243243003209 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 243243003210 oligomer interface [polypeptide binding]; other site 243243003211 metal binding site [ion binding]; metal-binding site 243243003212 metal binding site [ion binding]; metal-binding site 243243003213 putative Cl binding site [ion binding]; other site 243243003214 basic sphincter; other site 243243003215 hydrophobic gate; other site 243243003216 periplasmic entrance; other site 243243003217 malate dehydrogenase; Provisional; Region: PRK05442 243243003218 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 243243003219 NAD(P) binding site [chemical binding]; other site 243243003220 dimer interface [polypeptide binding]; other site 243243003221 malate binding site [chemical binding]; other site 243243003222 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 243243003223 Malic enzyme, N-terminal domain; Region: malic; pfam00390 243243003224 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 243243003225 putative NAD(P) binding site [chemical binding]; other site 243243003226 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 243243003227 short chain dehydrogenase; Provisional; Region: PRK07832 243243003228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243003229 NAD(P) binding site [chemical binding]; other site 243243003230 active site 243243003231 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 243243003232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243003233 NAD(P) binding site [chemical binding]; other site 243243003234 active site 243243003235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243243003236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243003237 putative substrate translocation pore; other site 243243003238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243003239 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 243243003240 RNase_H superfamily; Region: RNase_H_2; pfam13482 243243003241 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 243243003242 Part of AAA domain; Region: AAA_19; pfam13245 243243003243 AAA domain; Region: AAA_12; pfam13087 243243003244 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243003245 Cytochrome P450; Region: p450; cl12078 243243003246 SnoaL-like domain; Region: SnoaL_4; pfam13577 243243003247 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243003248 classical (c) SDRs; Region: SDR_c; cd05233 243243003249 NAD(P) binding site [chemical binding]; other site 243243003250 active site 243243003251 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243003252 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243003253 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243003254 classical (c) SDRs; Region: SDR_c; cd05233 243243003255 NAD(P) binding site [chemical binding]; other site 243243003256 active site 243243003257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243003258 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243003259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243003260 NAD(P) binding site [chemical binding]; other site 243243003261 active site 243243003262 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 243243003263 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243003264 Cytochrome P450; Region: p450; cl12078 243243003265 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243003266 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 243243003267 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 243243003268 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243243003269 ATP binding site [chemical binding]; other site 243243003270 Mg++ binding site [ion binding]; other site 243243003271 motif III; other site 243243003272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243003273 nucleotide binding region [chemical binding]; other site 243243003274 ATP-binding site [chemical binding]; other site 243243003275 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 243243003276 putative RNA binding site [nucleotide binding]; other site 243243003277 Acyltransferase family; Region: Acyl_transf_3; pfam01757 243243003278 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 243243003279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243003280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243003281 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243003282 Cytochrome P450; Region: p450; cl12078 243243003283 FAD binding domain; Region: FAD_binding_4; pfam01565 243243003284 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 243243003285 H+ Antiporter protein; Region: 2A0121; TIGR00900 243243003286 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 243243003287 Fe-S cluster binding site [ion binding]; other site 243243003288 DNA binding site [nucleotide binding] 243243003289 active site 243243003290 hypothetical protein; Validated; Region: PRK05868 243243003291 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243003292 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 243243003293 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243003294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243243003295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243243003296 metal binding site [ion binding]; metal-binding site 243243003297 active site 243243003298 I-site; other site 243243003299 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243243003300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243243003301 metal binding site [ion binding]; metal-binding site 243243003302 active site 243243003303 I-site; other site 243243003304 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243243003305 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 243243003306 HIT family signature motif; other site 243243003307 catalytic residue [active] 243243003308 amidase; Provisional; Region: PRK12470 243243003309 Amidase; Region: Amidase; cl11426 243243003310 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 243243003311 putative active site [active] 243243003312 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243243003313 cyclase homology domain; Region: CHD; cd07302 243243003314 nucleotidyl binding site; other site 243243003315 metal binding site [ion binding]; metal-binding site 243243003316 dimer interface [polypeptide binding]; other site 243243003317 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243003318 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243243003319 active site 243243003320 ATP binding site [chemical binding]; other site 243243003321 substrate binding site [chemical binding]; other site 243243003322 activation loop (A-loop); other site 243243003323 PknH-like extracellular domain; Region: PknH_C; pfam14032 243243003324 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 243243003325 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 243243003326 DNA binding site [nucleotide binding] 243243003327 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243003328 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243003329 phosphopeptide binding site; other site 243243003330 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243003331 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243243003332 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 243243003333 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 243243003334 Walker A/P-loop; other site 243243003335 ATP binding site [chemical binding]; other site 243243003336 Q-loop/lid; other site 243243003337 ABC transporter signature motif; other site 243243003338 Walker B; other site 243243003339 D-loop; other site 243243003340 H-loop/switch region; other site 243243003341 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243243003342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243243003343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243003344 Walker A/P-loop; other site 243243003345 ATP binding site [chemical binding]; other site 243243003346 Q-loop/lid; other site 243243003347 ABC transporter signature motif; other site 243243003348 Walker B; other site 243243003349 D-loop; other site 243243003350 H-loop/switch region; other site 243243003351 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 243243003352 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 243243003353 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243003354 catalytic core [active] 243243003355 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243003356 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243003357 active site 243243003358 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 243243003359 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 243243003360 active site 243243003361 metal binding site [ion binding]; metal-binding site 243243003362 DNA binding site [nucleotide binding] 243243003363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243003364 Walker A/P-loop; other site 243243003365 ATP binding site [chemical binding]; other site 243243003366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243003367 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 243243003368 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 243243003369 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 243243003370 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243243003371 Walker A/P-loop; other site 243243003372 ATP binding site [chemical binding]; other site 243243003373 Q-loop/lid; other site 243243003374 ABC transporter signature motif; other site 243243003375 Walker B; other site 243243003376 D-loop; other site 243243003377 H-loop/switch region; other site 243243003378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243243003379 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243243003380 Walker A/P-loop; other site 243243003381 ATP binding site [chemical binding]; other site 243243003382 Q-loop/lid; other site 243243003383 ABC transporter signature motif; other site 243243003384 Walker B; other site 243243003385 D-loop; other site 243243003386 H-loop/switch region; other site 243243003387 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243243003388 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 243243003389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243003390 dimer interface [polypeptide binding]; other site 243243003391 conserved gate region; other site 243243003392 putative PBP binding loops; other site 243243003393 ABC-ATPase subunit interface; other site 243243003394 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243243003395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243003396 dimer interface [polypeptide binding]; other site 243243003397 conserved gate region; other site 243243003398 putative PBP binding loops; other site 243243003399 ABC-ATPase subunit interface; other site 243243003400 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 243243003401 active site clefts [active] 243243003402 zinc binding site [ion binding]; other site 243243003403 dimer interface [polypeptide binding]; other site 243243003404 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243003405 CoenzymeA binding site [chemical binding]; other site 243243003406 subunit interaction site [polypeptide binding]; other site 243243003407 PHB binding site; other site 243243003408 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 243243003409 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243243003410 Active Sites [active] 243243003411 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 243243003412 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 243243003413 G1 box; other site 243243003414 putative GEF interaction site [polypeptide binding]; other site 243243003415 GTP/Mg2+ binding site [chemical binding]; other site 243243003416 Switch I region; other site 243243003417 G2 box; other site 243243003418 CysD dimerization site [polypeptide binding]; other site 243243003419 G3 box; other site 243243003420 Switch II region; other site 243243003421 G4 box; other site 243243003422 G5 box; other site 243243003423 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 243243003424 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 243243003425 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243243003426 ligand-binding site [chemical binding]; other site 243243003427 Rrf2 family protein; Region: rrf2_super; TIGR00738 243243003428 Transcriptional regulator; Region: Rrf2; pfam02082 243243003429 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 243243003430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243003431 metal binding site [ion binding]; metal-binding site 243243003432 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 243243003433 putative dimer interface [polypeptide binding]; other site 243243003434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243003435 ligand binding site [chemical binding]; other site 243243003436 Zn binding site [ion binding]; other site 243243003437 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243003438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243243003439 TrkA-N domain; Region: TrkA_N; pfam02254 243243003440 Ion channel; Region: Ion_trans_2; pfam07885 243243003441 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243243003442 TrkA-N domain; Region: TrkA_N; pfam02254 243243003443 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 243243003444 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 243243003445 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 243243003446 dimer interface [polypeptide binding]; other site 243243003447 ADP-ribose binding site [chemical binding]; other site 243243003448 active site 243243003449 nudix motif; other site 243243003450 metal binding site [ion binding]; metal-binding site 243243003451 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243003452 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 243243003453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 243243003454 MULE transposase domain; Region: MULE; pfam10551 243243003455 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243003456 putative transposase OrfB; Reviewed; Region: PHA02517 243243003457 HTH-like domain; Region: HTH_21; pfam13276 243243003458 Integrase core domain; Region: rve; pfam00665 243243003459 Integrase core domain; Region: rve_3; cl15866 243243003460 Transposase; Region: HTH_Tnp_1; cl17663 243243003461 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243003462 MULE transposase domain; Region: MULE; pfam10551 243243003463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243003464 sequence-specific DNA binding site [nucleotide binding]; other site 243243003465 salt bridge; other site 243243003466 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 243243003467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243003468 Walker A motif; other site 243243003469 ATP binding site [chemical binding]; other site 243243003470 Walker B motif; other site 243243003471 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 243243003472 FIC domain binding interface [polypeptide binding]; other site 243243003473 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 243243003474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243003475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243003476 homodimer interface [polypeptide binding]; other site 243243003477 catalytic residue [active] 243243003478 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243003479 MULE transposase domain; Region: MULE; pfam10551 243243003480 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243003481 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 243243003482 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243003483 MULE transposase domain; Region: MULE; pfam10551 243243003484 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243003485 Transposase IS200 like; Region: Y1_Tnp; pfam01797 243243003486 putative transposase OrfB; Reviewed; Region: PHA02517 243243003487 HTH-like domain; Region: HTH_21; pfam13276 243243003488 Integrase core domain; Region: rve; pfam00665 243243003489 Integrase core domain; Region: rve_3; cl15866 243243003490 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 243243003491 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243003492 MULE transposase domain; Region: MULE; pfam10551 243243003493 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243003494 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 243243003495 active site 243243003496 catalytic residues [active] 243243003497 DNA binding site [nucleotide binding] 243243003498 Int/Topo IB signature motif; other site 243243003499 Helix-turn-helix domain; Region: HTH_17; cl17695 243243003500 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 243243003501 nucleotide binding site [chemical binding]; other site 243243003502 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 243243003503 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 243243003504 catalytic residues [active] 243243003505 catalytic nucleophile [active] 243243003506 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243243003507 dimerization interface [polypeptide binding]; other site 243243003508 putative DNA binding site [nucleotide binding]; other site 243243003509 putative Zn2+ binding site [ion binding]; other site 243243003510 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 243243003511 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243003512 putative metal binding site [ion binding]; other site 243243003513 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 243243003514 arsenical-resistance protein; Region: acr3; TIGR00832 243243003515 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 243243003516 Low molecular weight phosphatase family; Region: LMWPc; cd00115 243243003517 active site 243243003518 Low molecular weight phosphatase family; Region: LMWPc; cl00105 243243003519 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 243243003520 active site 243243003521 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243003522 MULE transposase domain; Region: MULE; pfam10551 243243003523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 243243003524 Uncharacterized conserved protein [Function unknown]; Region: COG5323 243243003525 diaminopimelate decarboxylase; Region: lysA; TIGR01048 243243003526 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 243243003527 active site 243243003528 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243243003529 substrate binding site [chemical binding]; other site 243243003530 catalytic residues [active] 243243003531 dimer interface [polypeptide binding]; other site 243243003532 homoserine dehydrogenase; Provisional; Region: PRK06349 243243003533 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 243243003534 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 243243003535 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 243243003536 threonine synthase; Reviewed; Region: PRK06721 243243003537 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 243243003538 homodimer interface [polypeptide binding]; other site 243243003539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243003540 catalytic residue [active] 243243003541 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 243243003542 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 243243003543 transcription termination factor Rho; Provisional; Region: PRK12608 243243003544 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243243003545 RNA binding site [nucleotide binding]; other site 243243003546 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 243243003547 multimer interface [polypeptide binding]; other site 243243003548 Walker A motif; other site 243243003549 ATP binding site [chemical binding]; other site 243243003550 Walker B motif; other site 243243003551 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 243243003552 peptide chain release factor 1; Validated; Region: prfA; PRK00591 243243003553 PCRF domain; Region: PCRF; pfam03462 243243003554 RF-1 domain; Region: RF-1; pfam00472 243243003555 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 243243003556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243003557 S-adenosylmethionine binding site [chemical binding]; other site 243243003558 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 243243003559 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 243243003560 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 243243003561 Mg++ binding site [ion binding]; other site 243243003562 putative catalytic motif [active] 243243003563 substrate binding site [chemical binding]; other site 243243003564 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 243243003565 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 243243003566 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 243243003567 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 243243003568 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 243243003569 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 243243003570 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 243243003571 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 243243003572 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243243003573 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 243243003574 beta subunit interaction interface [polypeptide binding]; other site 243243003575 Walker A motif; other site 243243003576 ATP binding site [chemical binding]; other site 243243003577 Walker B motif; other site 243243003578 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243243003579 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 243243003580 core domain interface [polypeptide binding]; other site 243243003581 delta subunit interface [polypeptide binding]; other site 243243003582 epsilon subunit interface [polypeptide binding]; other site 243243003583 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 243243003584 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243243003585 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243243003586 alpha subunit interaction interface [polypeptide binding]; other site 243243003587 Walker A motif; other site 243243003588 ATP binding site [chemical binding]; other site 243243003589 Walker B motif; other site 243243003590 inhibitor binding site; inhibition site 243243003591 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243243003592 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 243243003593 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243243003594 gamma subunit interface [polypeptide binding]; other site 243243003595 epsilon subunit interface [polypeptide binding]; other site 243243003596 LBP interface [polypeptide binding]; other site 243243003597 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 243243003598 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 243243003599 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 243243003600 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 243243003601 hinge; other site 243243003602 active site 243243003603 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 243243003604 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 243243003605 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 243243003606 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243243003607 DNA binding site [nucleotide binding] 243243003608 active site 243243003609 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 243243003610 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 243243003611 AlkA N-terminal domain; Region: AlkA_N; pfam06029 243243003612 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 243243003613 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243243003614 minor groove reading motif; other site 243243003615 helix-hairpin-helix signature motif; other site 243243003616 substrate binding pocket [chemical binding]; other site 243243003617 active site 243243003618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243243003619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243003620 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 243243003621 putative dimerization interface [polypeptide binding]; other site 243243003622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243003623 putative substrate translocation pore; other site 243243003624 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243243003625 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243243003626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243003627 dimerization interface [polypeptide binding]; other site 243243003628 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243243003629 cyclase homology domain; Region: CHD; cd07302 243243003630 nucleotidyl binding site; other site 243243003631 metal binding site [ion binding]; metal-binding site 243243003632 dimer interface [polypeptide binding]; other site 243243003633 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 243243003634 hypothetical protein; Provisional; Region: PRK03298 243243003635 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 243243003636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243003637 dimer interface [polypeptide binding]; other site 243243003638 substrate binding site [chemical binding]; other site 243243003639 metal binding site [ion binding]; metal-binding site 243243003640 putative acyltransferase; Provisional; Region: PRK05790 243243003641 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243003642 dimer interface [polypeptide binding]; other site 243243003643 active site 243243003644 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 243243003645 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 243243003646 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 243243003647 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 243243003648 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 243243003649 active site 243243003650 homodimer interface [polypeptide binding]; other site 243243003651 catalytic site [active] 243243003652 acceptor binding site [chemical binding]; other site 243243003653 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 243243003654 putative homodimer interface [polypeptide binding]; other site 243243003655 putative active site pocket [active] 243243003656 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 243243003657 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 243243003658 DEAD/DEAH box helicase; Region: DEAD; pfam00270 243243003659 ATP binding site [chemical binding]; other site 243243003660 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243003661 putative Mg++ binding site [ion binding]; other site 243243003662 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 243243003663 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 243243003664 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 243243003665 active site 243243003666 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 243243003667 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 243243003668 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 243243003669 putative active site pocket [active] 243243003670 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 243243003671 Rhomboid family; Region: Rhomboid; pfam01694 243243003672 glutamate racemase; Provisional; Region: PRK00865 243243003673 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 243243003674 Ribonuclease PH; Region: RNase_PH_bact; cd11362 243243003675 ribonuclease PH; Reviewed; Region: rph; PRK00173 243243003676 hexamer interface [polypeptide binding]; other site 243243003677 active site 243243003678 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 243243003679 active site 243243003680 dimerization interface [polypeptide binding]; other site 243243003681 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 243243003682 Glucitol operon activator protein (GutM); Region: GutM; cl01890 243243003683 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 243243003684 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 243243003685 FAD binding pocket [chemical binding]; other site 243243003686 FAD binding motif [chemical binding]; other site 243243003687 phosphate binding motif [ion binding]; other site 243243003688 NAD binding pocket [chemical binding]; other site 243243003689 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243243003690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243003691 Walker A/P-loop; other site 243243003692 ATP binding site [chemical binding]; other site 243243003693 Q-loop/lid; other site 243243003694 ABC transporter signature motif; other site 243243003695 Walker B; other site 243243003696 D-loop; other site 243243003697 H-loop/switch region; other site 243243003698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243003699 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243243003700 Walker A/P-loop; other site 243243003701 ATP binding site [chemical binding]; other site 243243003702 Q-loop/lid; other site 243243003703 ABC transporter signature motif; other site 243243003704 Walker B; other site 243243003705 D-loop; other site 243243003706 H-loop/switch region; other site 243243003707 Phosphotransferase enzyme family; Region: APH; pfam01636 243243003708 Ecdysteroid kinase; Region: EcKinase; cl17738 243243003709 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 243243003710 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243003711 classical (c) SDRs; Region: SDR_c; cd05233 243243003712 NAD(P) binding site [chemical binding]; other site 243243003713 active site 243243003714 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003715 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003716 active site 243243003717 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243003718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243003719 NAD(P) binding site [chemical binding]; other site 243243003720 active site 243243003721 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 243243003722 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243003723 dimer interface [polypeptide binding]; other site 243243003724 active site 243243003725 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 243243003726 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243003727 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003729 active site 243243003730 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243243003731 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243003732 DNA-binding site [nucleotide binding]; DNA binding site 243243003733 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 243243003734 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243003735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003737 acyl-activating enzyme (AAE) consensus motif; other site 243243003738 acyl-activating enzyme (AAE) consensus motif; other site 243243003739 AMP binding site [chemical binding]; other site 243243003740 active site 243243003741 CoA binding site [chemical binding]; other site 243243003742 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243003743 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003744 acyl-activating enzyme (AAE) consensus motif; other site 243243003745 AMP binding site [chemical binding]; other site 243243003746 active site 243243003747 CoA binding site [chemical binding]; other site 243243003748 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243003749 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003750 acyl-activating enzyme (AAE) consensus motif; other site 243243003751 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003752 AMP binding site [chemical binding]; other site 243243003753 active site 243243003754 acyl-activating enzyme (AAE) consensus motif; other site 243243003755 CoA binding site [chemical binding]; other site 243243003756 enoyl-CoA hydratase; Provisional; Region: PRK05864 243243003757 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243003758 substrate binding site [chemical binding]; other site 243243003759 oxyanion hole (OAH) forming residues; other site 243243003760 trimer interface [polypeptide binding]; other site 243243003761 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243003762 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243003763 substrate binding site [chemical binding]; other site 243243003764 oxyanion hole (OAH) forming residues; other site 243243003765 trimer interface [polypeptide binding]; other site 243243003766 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243003767 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243003768 substrate binding site [chemical binding]; other site 243243003769 oxyanion hole (OAH) forming residues; other site 243243003770 trimer interface [polypeptide binding]; other site 243243003771 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243003772 CoenzymeA binding site [chemical binding]; other site 243243003773 subunit interaction site [polypeptide binding]; other site 243243003774 PHB binding site; other site 243243003775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243003776 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 243243003777 substrate binding site [chemical binding]; other site 243243003778 oxyanion hole (OAH) forming residues; other site 243243003779 trimer interface [polypeptide binding]; other site 243243003780 tetracycline repressor protein TetR; Provisional; Region: PRK13756 243243003781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243003782 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 243243003783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243003784 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243003785 NAD(P) binding site [chemical binding]; other site 243243003786 active site 243243003787 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 243243003788 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243243003789 active site 243243003790 inhibitor site; inhibition site 243243003791 dimer interface [polypeptide binding]; other site 243243003792 catalytic residue [active] 243243003793 enoyl-CoA hydratase; Provisional; Region: PRK06210 243243003794 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243003795 substrate binding site [chemical binding]; other site 243243003796 oxyanion hole (OAH) forming residues; other site 243243003797 trimer interface [polypeptide binding]; other site 243243003798 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243003799 acyl-CoA synthetase; Validated; Region: PRK07798 243243003800 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003801 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 243243003802 acyl-activating enzyme (AAE) consensus motif; other site 243243003803 acyl-activating enzyme (AAE) consensus motif; other site 243243003804 putative AMP binding site [chemical binding]; other site 243243003805 putative active site [active] 243243003806 putative CoA binding site [chemical binding]; other site 243243003807 CoA binding site [chemical binding]; other site 243243003808 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243003809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003810 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243003811 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003812 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003813 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003814 active site 243243003815 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 243243003816 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243003817 active site 243243003818 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243003819 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243003820 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243003821 Cytochrome P450; Region: p450; cl12078 243243003822 classical (c) SDRs; Region: SDR_c; cd05233 243243003823 NAD(P) binding site [chemical binding]; other site 243243003824 active site 243243003825 acyl-CoA synthetase; Validated; Region: PRK07798 243243003826 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003827 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 243243003828 acyl-activating enzyme (AAE) consensus motif; other site 243243003829 acyl-activating enzyme (AAE) consensus motif; other site 243243003830 putative AMP binding site [chemical binding]; other site 243243003831 putative active site [active] 243243003832 putative CoA binding site [chemical binding]; other site 243243003833 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243003834 CoenzymeA binding site [chemical binding]; other site 243243003835 subunit interaction site [polypeptide binding]; other site 243243003836 PHB binding site; other site 243243003837 Isochorismatase family; Region: Isochorismatase; pfam00857 243243003838 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 243243003839 catalytic triad [active] 243243003840 conserved cis-peptide bond; other site 243243003841 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243003842 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243003843 [2Fe-2S] cluster binding site [ion binding]; other site 243243003844 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243003845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243003846 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243003847 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 243243003848 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243003849 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 243243003850 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243003851 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243003852 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 243243003853 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243243003854 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 243243003855 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243003856 Cytochrome P450; Region: p450; cl12078 243243003857 short chain dehydrogenase; Provisional; Region: PRK06197 243243003858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243003859 NAD(P) binding site [chemical binding]; other site 243243003860 active site 243243003861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243003862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243003863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243003864 Walker A/P-loop; other site 243243003865 ATP binding site [chemical binding]; other site 243243003866 Predicted membrane protein [Function unknown]; Region: COG1511 243243003867 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 243243003868 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 243243003869 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 243243003870 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 243243003871 NAD binding site [chemical binding]; other site 243243003872 catalytic Zn binding site [ion binding]; other site 243243003873 substrate binding site [chemical binding]; other site 243243003874 structural Zn binding site [ion binding]; other site 243243003875 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243003876 Cytochrome P450; Region: p450; cl12078 243243003877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243003878 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243003879 substrate binding pocket [chemical binding]; other site 243243003880 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003881 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243003882 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243243003883 active site 243243003884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003886 active site 243243003887 PAS fold; Region: PAS_4; pfam08448 243243003888 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 243243003889 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243243003890 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243243003891 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 243243003892 ATP binding site [chemical binding]; other site 243243003893 Mg2+ binding site [ion binding]; other site 243243003894 G-X-G motif; other site 243243003895 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 243243003896 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 243243003897 Moco binding site; other site 243243003898 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 243243003899 metal coordination site [ion binding]; other site 243243003900 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243003901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243003902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243003903 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243003904 CoenzymeA binding site [chemical binding]; other site 243243003905 subunit interaction site [polypeptide binding]; other site 243243003906 PHB binding site; other site 243243003907 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243003908 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243003909 acyl-activating enzyme (AAE) consensus motif; other site 243243003910 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243003911 putative AMP binding site [chemical binding]; other site 243243003912 putative active site [active] 243243003913 acyl-activating enzyme (AAE) consensus motif; other site 243243003914 putative CoA binding site [chemical binding]; other site 243243003915 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003916 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 243243003917 active site 243243003918 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003919 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003920 active site 243243003921 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003922 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003923 active site 243243003924 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243003925 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243003926 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243003927 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243003928 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243003929 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 243243003930 classical (c) SDRs; Region: SDR_c; cd05233 243243003931 NAD(P) binding site [chemical binding]; other site 243243003932 active site 243243003933 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243243003934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243003935 DNA-binding site [nucleotide binding]; DNA binding site 243243003936 FCD domain; Region: FCD; pfam07729 243243003937 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243003938 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243003939 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243003940 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243003941 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 243243003942 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243243003943 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243003944 Cytochrome P450; Region: p450; cl12078 243243003945 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243003946 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243003947 [2Fe-2S] cluster binding site [ion binding]; other site 243243003948 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243243003949 hydrophobic ligand binding site; other site 243243003950 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 243243003951 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 243243003952 acyl-activating enzyme (AAE) consensus motif; other site 243243003953 putative AMP binding site [chemical binding]; other site 243243003954 putative active site [active] 243243003955 putative CoA binding site [chemical binding]; other site 243243003956 SnoaL-like domain; Region: SnoaL_4; pfam13577 243243003957 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 243243003958 active site 243243003959 catalytic site [active] 243243003960 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 243243003961 putative active site [active] 243243003962 putative catalytic site [active] 243243003963 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 243243003964 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243003965 NAD binding site [chemical binding]; other site 243243003966 catalytic residues [active] 243243003967 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 243243003968 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243003969 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243003970 [2Fe-2S] cluster binding site [ion binding]; other site 243243003971 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 243243003972 putative alpha subunit interface [polypeptide binding]; other site 243243003973 putative active site [active] 243243003974 putative substrate binding site [chemical binding]; other site 243243003975 Fe binding site [ion binding]; other site 243243003976 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 243243003977 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243003978 DNA binding residues [nucleotide binding] 243243003979 dimer interface [polypeptide binding]; other site 243243003980 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 243243003981 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243243003982 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 243243003983 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243243003984 phosphate binding site [ion binding]; other site 243243003985 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 243243003986 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 243243003987 putative active site [active] 243243003988 putative catalytic site [active] 243243003989 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243243003990 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243243003991 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 243243003992 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 243243003993 putative NAD(P) binding site [chemical binding]; other site 243243003994 active site 243243003995 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 243243003996 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 243243003997 active site 243243003998 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 243243003999 hypothetical protein; Provisional; Region: PRK07907 243243004000 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 243243004001 active site 243243004002 metal binding site [ion binding]; metal-binding site 243243004003 dimer interface [polypeptide binding]; other site 243243004004 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 243243004005 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243243004006 catalytic triad [active] 243243004007 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 243243004008 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 243243004009 hypothetical protein; Provisional; Region: PRK01346 243243004010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 243243004011 MMPL family; Region: MMPL; pfam03176 243243004012 MMPL family; Region: MMPL; pfam03176 243243004013 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 243243004014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243243004015 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 243243004016 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243243004017 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 243243004018 catalytic site [active] 243243004019 putative active site [active] 243243004020 putative substrate binding site [chemical binding]; other site 243243004021 dimer interface [polypeptide binding]; other site 243243004022 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 243243004023 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243243004024 classical (c) SDRs; Region: SDR_c; cd05233 243243004025 NAD(P) binding site [chemical binding]; other site 243243004026 active site 243243004027 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 243243004028 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243004029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243004030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004031 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 243243004032 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243243004033 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 243243004034 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 243243004035 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243243004036 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 243243004037 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 243243004038 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243243004039 carboxyltransferase (CT) interaction site; other site 243243004040 biotinylation site [posttranslational modification]; other site 243243004041 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004043 active site 243243004044 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 243243004045 putative active site [active] 243243004046 putative catalytic site [active] 243243004047 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 243243004048 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 243243004049 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243243004050 tetramer interface [polypeptide binding]; other site 243243004051 TPP-binding site [chemical binding]; other site 243243004052 heterodimer interface [polypeptide binding]; other site 243243004053 phosphorylation loop region [posttranslational modification] 243243004054 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243243004055 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 243243004056 alpha subunit interface [polypeptide binding]; other site 243243004057 TPP binding site [chemical binding]; other site 243243004058 heterodimer interface [polypeptide binding]; other site 243243004059 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243243004060 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243243004061 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 243243004062 E3 interaction surface; other site 243243004063 lipoyl attachment site [posttranslational modification]; other site 243243004064 e3 binding domain; Region: E3_binding; pfam02817 243243004065 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243243004066 enoyl-CoA hydratase; Provisional; Region: PRK05870 243243004067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243004068 substrate binding site [chemical binding]; other site 243243004069 oxyanion hole (OAH) forming residues; other site 243243004070 trimer interface [polypeptide binding]; other site 243243004071 putative transposase OrfB; Reviewed; Region: PHA02517 243243004072 HTH-like domain; Region: HTH_21; pfam13276 243243004073 Integrase core domain; Region: rve; pfam00665 243243004074 Integrase core domain; Region: rve_3; cl15866 243243004075 Cutinase; Region: Cutinase; pfam01083 243243004076 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 243243004077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243004078 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243004079 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243004080 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 243243004081 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 243243004082 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243004083 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243243004084 putative acyl-acceptor binding pocket; other site 243243004085 Transposase; Region: HTH_Tnp_1; cl17663 243243004086 putative transposase OrfB; Reviewed; Region: PHA02517 243243004087 HTH-like domain; Region: HTH_21; pfam13276 243243004088 Integrase core domain; Region: rve; pfam00665 243243004089 Integrase core domain; Region: rve_3; cl15866 243243004090 Copper resistance protein D; Region: CopD; pfam05425 243243004091 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 243243004092 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243243004093 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243243004094 dimer interface [polypeptide binding]; other site 243243004095 ssDNA binding site [nucleotide binding]; other site 243243004096 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243243004097 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 243243004098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243243004099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243243004100 ABC transporter; Region: ABC_tran_2; pfam12848 243243004101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243243004102 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 243243004103 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243243004104 active site 243243004105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243004106 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 243243004107 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 243243004108 active site 243243004109 catalytic site [active] 243243004110 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 243243004111 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 243243004112 apolar tunnel; other site 243243004113 heme binding site [chemical binding]; other site 243243004114 dimerization interface [polypeptide binding]; other site 243243004115 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 243243004116 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243004117 active site 243243004118 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 243243004119 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 243243004120 Zn binding site [ion binding]; other site 243243004121 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 243243004122 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 243243004123 catalytic residues [active] 243243004124 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 243243004125 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 243243004126 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 243243004127 putative DNA binding site [nucleotide binding]; other site 243243004128 catalytic residue [active] 243243004129 putative H2TH interface [polypeptide binding]; other site 243243004130 putative catalytic residues [active] 243243004131 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243243004132 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243243004133 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243243004134 Beta-lactamase; Region: Beta-lactamase; pfam00144 243243004135 trigger factor; Provisional; Region: tig; PRK01490 243243004136 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243243004137 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 243243004138 Clp protease; Region: CLP_protease; pfam00574 243243004139 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243243004140 oligomer interface [polypeptide binding]; other site 243243004141 active site residues [active] 243243004142 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 243243004143 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243243004144 oligomer interface [polypeptide binding]; other site 243243004145 active site residues [active] 243243004146 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 243243004147 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 243243004148 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 243243004149 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 243243004150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243004151 Walker A motif; other site 243243004152 ATP binding site [chemical binding]; other site 243243004153 Walker B motif; other site 243243004154 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243243004155 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 243243004156 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 243243004157 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243243004158 dimer interface [polypeptide binding]; other site 243243004159 PYR/PP interface [polypeptide binding]; other site 243243004160 TPP binding site [chemical binding]; other site 243243004161 substrate binding site [chemical binding]; other site 243243004162 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 243243004163 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 243243004164 TPP-binding site [chemical binding]; other site 243243004165 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 243243004166 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 243243004167 GTP binding site; other site 243243004168 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 243243004169 Uncharacterized conserved protein [Function unknown]; Region: COG3268 243243004170 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 243243004171 NAD(P) binding pocket [chemical binding]; other site 243243004172 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 243243004173 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243243004174 active site 243243004175 HIGH motif; other site 243243004176 nucleotide binding site [chemical binding]; other site 243243004177 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243243004178 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243243004179 active site 243243004180 KMSKS motif; other site 243243004181 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 243243004182 tRNA binding surface [nucleotide binding]; other site 243243004183 anticodon binding site; other site 243243004184 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 243243004185 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 243243004186 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243243004187 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 243243004188 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 243243004189 active site 243243004190 multimer interface [polypeptide binding]; other site 243243004191 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243243004192 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 243243004193 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243243004194 homodimer interface [polypeptide binding]; other site 243243004195 oligonucleotide binding site [chemical binding]; other site 243243004196 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 243243004197 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 243243004198 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 243243004199 GTPase CgtA; Reviewed; Region: obgE; PRK12296 243243004200 GTP1/OBG; Region: GTP1_OBG; pfam01018 243243004201 Obg GTPase; Region: Obg; cd01898 243243004202 G1 box; other site 243243004203 GTP/Mg2+ binding site [chemical binding]; other site 243243004204 Switch I region; other site 243243004205 G2 box; other site 243243004206 G3 box; other site 243243004207 Switch II region; other site 243243004208 G4 box; other site 243243004209 G5 box; other site 243243004210 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 243243004211 gamma-glutamyl kinase; Provisional; Region: PRK05429 243243004212 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 243243004213 nucleotide binding site [chemical binding]; other site 243243004214 homotetrameric interface [polypeptide binding]; other site 243243004215 putative phosphate binding site [ion binding]; other site 243243004216 putative allosteric binding site; other site 243243004217 PUA domain; Region: PUA; pfam01472 243243004218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243004219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004220 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243004221 Cytochrome P450; Region: p450; cl12078 243243004222 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 243243004223 NAD+ binding site [chemical binding]; other site 243243004224 substrate binding site [chemical binding]; other site 243243004225 Zn binding site [ion binding]; other site 243243004226 Isochorismatase family; Region: Isochorismatase; pfam00857 243243004227 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 243243004228 catalytic triad [active] 243243004229 conserved cis-peptide bond; other site 243243004230 NAD synthetase; Reviewed; Region: nadE; PRK02628 243243004231 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 243243004232 multimer interface [polypeptide binding]; other site 243243004233 active site 243243004234 catalytic triad [active] 243243004235 protein interface 1 [polypeptide binding]; other site 243243004236 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 243243004237 homodimer interface [polypeptide binding]; other site 243243004238 NAD binding pocket [chemical binding]; other site 243243004239 ATP binding pocket [chemical binding]; other site 243243004240 Mg binding site [ion binding]; other site 243243004241 active-site loop [active] 243243004242 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 243243004243 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 243243004244 substrate binding site [chemical binding]; other site 243243004245 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 243243004246 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 243243004247 substrate binding site [chemical binding]; other site 243243004248 ligand binding site [chemical binding]; other site 243243004249 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 243243004250 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243243004251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243004252 DNA-binding site [nucleotide binding]; DNA binding site 243243004253 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 243243004254 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243243004255 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 243243004256 substrate binding site [chemical binding]; other site 243243004257 ATP binding site [chemical binding]; other site 243243004258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243004259 dimerization interface [polypeptide binding]; other site 243243004260 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 243243004261 cyclase homology domain; Region: CHD; cd07302 243243004262 nucleotidyl binding site; other site 243243004263 metal binding site [ion binding]; metal-binding site 243243004264 dimer interface [polypeptide binding]; other site 243243004265 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 243243004266 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 243243004267 putative catalytic cysteine [active] 243243004268 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243243004269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243004270 Walker A motif; other site 243243004271 ATP binding site [chemical binding]; other site 243243004272 Walker B motif; other site 243243004273 arginine finger; other site 243243004274 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 243243004275 NifQ; Region: NifQ; pfam04891 243243004276 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243243004277 metal ion-dependent adhesion site (MIDAS); other site 243243004278 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 243243004279 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 243243004280 active site 243243004281 (T/H)XGH motif; other site 243243004282 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 243243004283 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243004284 catalytic core [active] 243243004285 EDD domain protein, DegV family; Region: DegV; TIGR00762 243243004286 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 243243004287 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 243243004288 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243004289 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243004290 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243243004291 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 243243004292 acyl-CoA synthetase; Validated; Region: PRK05850 243243004293 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243243004294 acyl-activating enzyme (AAE) consensus motif; other site 243243004295 active site 243243004296 PE-PPE domain; Region: PE-PPE; pfam08237 243243004297 Transport protein; Region: actII; TIGR00833 243243004298 Condensation domain; Region: Condensation; pfam00668 243243004299 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243243004300 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243004301 active site 243243004302 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243243004303 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243004304 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 243243004305 KR domain; Region: KR; pfam08659 243243004306 putative NADP binding site [chemical binding]; other site 243243004307 active site 243243004308 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243004309 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243004310 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243243004311 active site 243243004312 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243243004313 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243004314 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243243004315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004316 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243243004317 Enoylreductase; Region: PKS_ER; smart00829 243243004318 NAD(P) binding site [chemical binding]; other site 243243004319 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 243243004320 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243243004321 putative NADP binding site [chemical binding]; other site 243243004322 active site 243243004323 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243004324 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 243243004325 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 243243004326 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243004327 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243243004328 active site 243243004329 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 243243004330 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 243243004331 FAD binding site [chemical binding]; other site 243243004332 substrate binding site [chemical binding]; other site 243243004333 catalytic base [active] 243243004334 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 243243004335 Helix-hairpin-helix motif; Region: HHH; pfam00633 243243004336 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 243243004337 Competence protein; Region: Competence; pfam03772 243243004338 hypothetical protein; Reviewed; Region: PRK07914 243243004339 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 243243004340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 243243004341 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 243243004342 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243243004343 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 243243004344 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243243004345 ribonuclease Z; Reviewed; Region: PRK00055 243243004346 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 243243004347 FOG: CBS domain [General function prediction only]; Region: COG0517 243243004348 PemK-like protein; Region: PemK; pfam02452 243243004349 GTP-binding protein LepA; Provisional; Region: PRK05433 243243004350 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 243243004351 G1 box; other site 243243004352 putative GEF interaction site [polypeptide binding]; other site 243243004353 GTP/Mg2+ binding site [chemical binding]; other site 243243004354 Switch I region; other site 243243004355 G2 box; other site 243243004356 G3 box; other site 243243004357 Switch II region; other site 243243004358 G4 box; other site 243243004359 G5 box; other site 243243004360 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 243243004361 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 243243004362 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 243243004363 PknH-like extracellular domain; Region: PknH_C; pfam14032 243243004364 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 243243004365 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 243243004366 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243243004367 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243243004368 sulfate transport protein; Provisional; Region: cysT; CHL00187 243243004369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243004370 dimer interface [polypeptide binding]; other site 243243004371 conserved gate region; other site 243243004372 putative PBP binding loops; other site 243243004373 ABC-ATPase subunit interface; other site 243243004374 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243243004375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243004376 dimer interface [polypeptide binding]; other site 243243004377 conserved gate region; other site 243243004378 putative PBP binding loops; other site 243243004379 ABC-ATPase subunit interface; other site 243243004380 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 243243004381 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 243243004382 Walker A/P-loop; other site 243243004383 ATP binding site [chemical binding]; other site 243243004384 Q-loop/lid; other site 243243004385 ABC transporter signature motif; other site 243243004386 Walker B; other site 243243004387 D-loop; other site 243243004388 H-loop/switch region; other site 243243004389 TOBE domain; Region: TOBE; pfam03459 243243004390 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 243243004391 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243243004392 Active Sites [active] 243243004393 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 243243004394 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243243004395 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243243004396 coproporphyrinogen III oxidase; Validated; Region: PRK05628 243243004397 HemN C-terminal domain; Region: HemN_C; pfam06969 243243004398 Predicted permease [General function prediction only]; Region: COG3329 243243004399 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243004400 MULE transposase domain; Region: MULE; pfam10551 243243004401 salicylate synthase MbtI; Reviewed; Region: PRK07912 243243004402 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243243004403 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 243243004404 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 243243004405 homodimer interface [polypeptide binding]; other site 243243004406 putative substrate binding pocket [chemical binding]; other site 243243004407 diiron center [ion binding]; other site 243243004408 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 243243004409 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243004410 DNA binding residues [nucleotide binding] 243243004411 putative dimer interface [polypeptide binding]; other site 243243004412 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243004413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243004414 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 243243004415 classical (c) SDRs; Region: SDR_c; cd05233 243243004416 short chain dehydrogenase; Provisional; Region: PRK05650 243243004417 NAD(P) binding site [chemical binding]; other site 243243004418 active site 243243004419 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 243243004420 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 243243004421 hypothetical protein; Provisional; Region: PRK02268 243243004422 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 243243004423 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 243243004424 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 243243004425 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 243243004426 putative active site [active] 243243004427 putative metal binding site [ion binding]; other site 243243004428 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243243004429 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243243004430 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 243243004431 hypothetical protein; Provisional; Region: PRK07236 243243004432 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243004433 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243004434 MULE transposase domain; Region: MULE; pfam10551 243243004435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243004436 Walker A motif; other site 243243004437 ATP binding site [chemical binding]; other site 243243004438 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243004439 mce related protein; Region: MCE; pfam02470 243243004440 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243004441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004442 NAD(P) binding site [chemical binding]; other site 243243004443 active site 243243004444 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243004445 classical (c) SDRs; Region: SDR_c; cd05233 243243004446 NAD(P) binding site [chemical binding]; other site 243243004447 active site 243243004448 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243004449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243004450 substrate binding site [chemical binding]; other site 243243004451 oxyanion hole (OAH) forming residues; other site 243243004452 trimer interface [polypeptide binding]; other site 243243004453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004454 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243004455 NAD(P) binding site [chemical binding]; other site 243243004456 active site 243243004457 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004458 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004461 active site 243243004462 short chain dehydrogenase; Provisional; Region: PRK08278 243243004463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004464 NAD(P) binding site [chemical binding]; other site 243243004465 active site 243243004466 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243004467 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 243243004468 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243004469 active site 243243004470 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243004471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243004472 substrate binding site [chemical binding]; other site 243243004473 oxyanion hole (OAH) forming residues; other site 243243004474 trimer interface [polypeptide binding]; other site 243243004475 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243243004476 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243004477 CoenzymeA binding site [chemical binding]; other site 243243004478 subunit interaction site [polypeptide binding]; other site 243243004479 PHB binding site; other site 243243004480 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243243004481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243004482 DNA-binding site [nucleotide binding]; DNA binding site 243243004483 FCD domain; Region: FCD; pfam07729 243243004484 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004485 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004486 active site 243243004487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004488 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004489 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004490 active site 243243004491 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 243243004492 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 243243004493 NAD binding site [chemical binding]; other site 243243004494 catalytic residues [active] 243243004495 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243004496 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243004497 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 243243004498 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243004499 short chain dehydrogenase; Provisional; Region: PRK06197 243243004500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004501 NAD(P) binding site [chemical binding]; other site 243243004502 active site 243243004503 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243004504 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243243004505 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243243004506 active site 243243004507 HIGH motif; other site 243243004508 nucleotide binding site [chemical binding]; other site 243243004509 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243004510 classical (c) SDRs; Region: SDR_c; cd05233 243243004511 NAD(P) binding site [chemical binding]; other site 243243004512 active site 243243004513 short chain dehydrogenase; Provisional; Region: PRK07791 243243004514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004515 NAD(P) binding site [chemical binding]; other site 243243004516 active site 243243004517 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 243243004518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004520 active site 243243004521 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243004522 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243004523 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004524 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243243004525 active site 243243004526 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243004527 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243004528 acyl-activating enzyme (AAE) consensus motif; other site 243243004529 AMP binding site [chemical binding]; other site 243243004530 active site 243243004531 CoA binding site [chemical binding]; other site 243243004532 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243004533 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243004534 Cytochrome P450; Region: p450; cl12078 243243004535 lipid-transfer protein; Provisional; Region: PRK08256 243243004536 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243004537 active site 243243004538 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243004539 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243004540 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243004541 acyl-activating enzyme (AAE) consensus motif; other site 243243004542 acyl-activating enzyme (AAE) consensus motif; other site 243243004543 AMP binding site [chemical binding]; other site 243243004544 active site 243243004545 CoA binding site [chemical binding]; other site 243243004546 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243004547 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243004548 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243004549 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243004550 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 243243004551 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 243243004552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004553 NAD(P) binding site [chemical binding]; other site 243243004554 active site 243243004555 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243004556 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243004557 substrate binding site [chemical binding]; other site 243243004558 oxyanion hole (OAH) forming residues; other site 243243004559 trimer interface [polypeptide binding]; other site 243243004560 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 243243004561 NADH(P)-binding; Region: NAD_binding_10; pfam13460 243243004562 NAD binding site [chemical binding]; other site 243243004563 substrate binding site [chemical binding]; other site 243243004564 putative active site [active] 243243004565 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243004566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243004567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004568 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 243243004569 DinB superfamily; Region: DinB_2; pfam12867 243243004570 Integrase core domain; Region: rve_3; pfam13683 243243004571 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243004572 MULE transposase domain; Region: MULE; pfam10551 243243004573 Homeodomain-like domain; Region: HTH_23; cl17451 243243004574 Winged helix-turn helix; Region: HTH_29; pfam13551 243243004575 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243004576 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243004577 [2Fe-2S] cluster binding site [ion binding]; other site 243243004578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004579 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243004580 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243243004581 iron-sulfur cluster [ion binding]; other site 243243004582 [2Fe-2S] cluster binding site [ion binding]; other site 243243004583 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243004584 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243004585 putative acyltransferase; Provisional; Region: PRK05790 243243004586 dimer interface [polypeptide binding]; other site 243243004587 active site 243243004588 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 243243004589 putative active site [active] 243243004590 putative catalytic site [active] 243243004591 lipid-transfer protein; Provisional; Region: PRK07855 243243004592 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243004593 active site 243243004594 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243243004595 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243004596 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243004597 acyl-activating enzyme (AAE) consensus motif; other site 243243004598 acyl-activating enzyme (AAE) consensus motif; other site 243243004599 putative AMP binding site [chemical binding]; other site 243243004600 putative active site [active] 243243004601 putative CoA binding site [chemical binding]; other site 243243004602 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 243243004603 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243004604 putative transposase OrfB; Reviewed; Region: PHA02517 243243004605 HTH-like domain; Region: HTH_21; pfam13276 243243004606 Integrase core domain; Region: rve; pfam00665 243243004607 Integrase core domain; Region: rve_3; cl15866 243243004608 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243004609 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 243243004610 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243243004611 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004612 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004613 active site 243243004614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004615 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243004616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004617 active site 243243004618 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004619 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004620 active site 243243004621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004622 active site 243243004623 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243004624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243004625 acyl-activating enzyme (AAE) consensus motif; other site 243243004626 AMP binding site [chemical binding]; other site 243243004627 active site 243243004628 CoA binding site [chemical binding]; other site 243243004629 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243004630 classical (c) SDRs; Region: SDR_c; cd05233 243243004631 NAD(P) binding site [chemical binding]; other site 243243004632 active site 243243004633 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243004634 active site 1 [active] 243243004635 active site 2 [active] 243243004636 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243004637 active site 2 [active] 243243004638 active site 1 [active] 243243004639 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004640 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004641 active site 243243004642 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243004643 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243004644 substrate binding site [chemical binding]; other site 243243004645 oxyanion hole (OAH) forming residues; other site 243243004646 trimer interface [polypeptide binding]; other site 243243004647 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 243243004648 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243004649 CoenzymeA binding site [chemical binding]; other site 243243004650 Transposase; Region: HTH_Tnp_1; cl17663 243243004651 putative transposase OrfB; Reviewed; Region: PHA02517 243243004652 HTH-like domain; Region: HTH_21; pfam13276 243243004653 Integrase core domain; Region: rve; pfam00665 243243004654 Integrase core domain; Region: rve_3; cl15866 243243004655 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243004656 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243004657 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 243243004658 short chain dehydrogenase; Provisional; Region: PRK08628 243243004659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004660 NAD(P) binding site [chemical binding]; other site 243243004661 active site 243243004662 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243004663 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243004664 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243004665 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243004666 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243004667 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243004668 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243004669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004671 active site 243243004672 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243004673 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 243243004674 NAD(P) binding site [chemical binding]; other site 243243004675 catalytic residues [active] 243243004676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243004677 enoyl-CoA hydratase; Provisional; Region: PRK07799 243243004678 substrate binding site [chemical binding]; other site 243243004679 oxyanion hole (OAH) forming residues; other site 243243004680 trimer interface [polypeptide binding]; other site 243243004681 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243243004682 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243004683 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243004684 acyl-activating enzyme (AAE) consensus motif; other site 243243004685 acyl-activating enzyme (AAE) consensus motif; other site 243243004686 putative AMP binding site [chemical binding]; other site 243243004687 putative active site [active] 243243004688 putative CoA binding site [chemical binding]; other site 243243004689 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 243243004690 inter-subunit interface; other site 243243004691 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243243004692 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243004693 iron-sulfur cluster [ion binding]; other site 243243004694 [2Fe-2S] cluster binding site [ion binding]; other site 243243004695 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 243243004696 putative alpha subunit interface [polypeptide binding]; other site 243243004697 putative active site [active] 243243004698 putative substrate binding site [chemical binding]; other site 243243004699 Fe binding site [ion binding]; other site 243243004700 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243004701 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243004702 active site 243243004703 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243004704 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 243243004705 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 243243004706 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 243243004707 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243004708 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 243243004709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004710 active site 243243004711 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243004712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004714 active site 243243004715 thiolase; Provisional; Region: PRK06158 243243004716 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243004717 active site 243243004718 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243004719 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243004720 acyl-activating enzyme (AAE) consensus motif; other site 243243004721 AMP binding site [chemical binding]; other site 243243004722 active site 243243004723 CoA binding site [chemical binding]; other site 243243004724 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243004725 classical (c) SDRs; Region: SDR_c; cd05233 243243004726 NAD(P) binding site [chemical binding]; other site 243243004727 active site 243243004728 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243004729 CoenzymeA binding site [chemical binding]; other site 243243004730 subunit interaction site [polypeptide binding]; other site 243243004731 PHB binding site; other site 243243004732 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243004733 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243004734 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243004735 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243004736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004737 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243004738 lipid-transfer protein; Provisional; Region: PRK07855 243243004739 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243004740 active site 243243004741 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243004742 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243004743 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243004744 classical (c) SDRs; Region: SDR_c; cd05233 243243004745 NAD(P) binding site [chemical binding]; other site 243243004746 active site 243243004747 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243243004748 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243004749 NAD(P) binding site [chemical binding]; other site 243243004750 catalytic residues [active] 243243004751 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243004752 MULE transposase domain; Region: MULE; pfam10551 243243004753 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243004754 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 243243004755 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243243004756 Phosphotransferase enzyme family; Region: APH; pfam01636 243243004757 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243004758 putative active site [active] 243243004759 putative substrate binding site [chemical binding]; other site 243243004760 ATP binding site [chemical binding]; other site 243243004761 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 243243004762 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243004763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243004764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004765 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243004766 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 243243004767 Subunit I/III interface [polypeptide binding]; other site 243243004768 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243004769 short chain dehydrogenase; Provisional; Region: PRK07791 243243004770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004771 NAD(P) binding site [chemical binding]; other site 243243004772 active site 243243004773 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243004774 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243004775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243004776 substrate binding site [chemical binding]; other site 243243004777 oxyanion hole (OAH) forming residues; other site 243243004778 trimer interface [polypeptide binding]; other site 243243004779 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243004780 Cytochrome P450; Region: p450; cl12078 243243004781 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243243004782 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243243004783 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 243243004784 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 243243004785 NAD binding site [chemical binding]; other site 243243004786 catalytic Zn binding site [ion binding]; other site 243243004787 substrate binding site [chemical binding]; other site 243243004788 structural Zn binding site [ion binding]; other site 243243004789 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 243243004790 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243004791 NAD binding site [chemical binding]; other site 243243004792 catalytic residues [active] 243243004793 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 243243004794 active site 2 [active] 243243004795 active site 1 [active] 243243004796 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243004797 active site 2 [active] 243243004798 active site 1 [active] 243243004799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243004800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243004803 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 243243004804 active site 243243004805 metal binding site [ion binding]; metal-binding site 243243004806 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 243243004807 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 243243004808 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243243004809 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243004810 Cytochrome P450; Region: p450; cl12078 243243004811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004812 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243004813 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243004814 Cytochrome P450; Region: p450; cl12078 243243004815 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243004816 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 243243004817 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243243004818 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243004819 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 243243004820 acyl-activating enzyme (AAE) consensus motif; other site 243243004821 putative AMP binding site [chemical binding]; other site 243243004822 putative active site [active] 243243004823 putative CoA binding site [chemical binding]; other site 243243004824 classical (c) SDRs; Region: SDR_c; cd05233 243243004825 short chain dehydrogenase; Provisional; Region: PRK08267 243243004826 NAD(P) binding site [chemical binding]; other site 243243004827 active site 243243004828 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 243243004829 pyruvate phosphate dikinase; Provisional; Region: PRK05878 243243004830 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243243004831 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243243004832 Nitroreductase family; Region: Nitroreductase; pfam00881 243243004833 FMN binding site [chemical binding]; other site 243243004834 dimer interface [polypeptide binding]; other site 243243004835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004836 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243004837 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004839 active site 243243004840 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243004841 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243004842 active site 243243004843 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243004844 active site 243243004845 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243004846 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243004847 Ecdysteroid kinase; Region: EcKinase; cl17738 243243004848 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243004849 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243004850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243004851 short chain dehydrogenase; Provisional; Region: PRK06197 243243004852 NAD(P) binding site [chemical binding]; other site 243243004853 active site 243243004854 Divergent AAA domain; Region: AAA_4; pfam04326 243243004855 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243243004856 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243004857 MULE transposase domain; Region: MULE; pfam10551 243243004858 short chain dehydrogenase; Provisional; Region: PRK06180 243243004859 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 243243004860 NADP binding site [chemical binding]; other site 243243004861 active site 243243004862 steroid binding site; other site 243243004863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243004864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243004865 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243243004866 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 243243004867 potential catalytic triad [active] 243243004868 conserved cys residue [active] 243243004869 topology modulation protein; Reviewed; Region: PRK08118 243243004870 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 243243004871 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243243004872 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 243243004873 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243243004874 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 243243004875 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 243243004876 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243004877 MULE transposase domain; Region: MULE; pfam10551 243243004878 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243243004879 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243243004880 putative dimer interface [polypeptide binding]; other site 243243004881 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 243243004882 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243004883 DNA binding residues [nucleotide binding] 243243004884 putative dimer interface [polypeptide binding]; other site 243243004885 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243243004886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243243004887 metal binding site [ion binding]; metal-binding site 243243004888 active site 243243004889 I-site; other site 243243004890 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 243243004891 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243004892 PPE family; Region: PPE; pfam00823 243243004893 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 243243004894 Winged helix-turn helix; Region: HTH_29; pfam13551 243243004895 Integrase core domain; Region: rve; pfam00665 243243004896 Integrase core domain; Region: rve_3; pfam13683 243243004897 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243243004898 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243243004899 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243243004900 peptide synthase; Provisional; Region: PRK12316 243243004901 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243004902 PPE family; Region: PPE; pfam00823 243243004903 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243004904 Short C-terminal domain; Region: SHOCT; pfam09851 243243004905 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 243243004906 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 243243004907 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 243243004908 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 243243004909 acyl-activating enzyme (AAE) consensus motif; other site 243243004910 active site 243243004911 AMP binding site [chemical binding]; other site 243243004912 substrate binding site [chemical binding]; other site 243243004913 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 243243004914 Condensation domain; Region: Condensation; pfam00668 243243004915 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243004916 Nonribosomal peptide synthase; Region: NRPS; pfam08415 243243004917 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 243243004918 acyl-activating enzyme (AAE) consensus motif; other site 243243004919 AMP binding site [chemical binding]; other site 243243004920 Thioesterase domain; Region: Thioesterase; pfam00975 243243004921 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243004922 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243243004923 active site 243243004924 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243004925 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 243243004926 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243243004927 NADP binding site [chemical binding]; other site 243243004928 active site 243243004929 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243004930 Condensation domain; Region: Condensation; pfam00668 243243004931 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243004932 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243004933 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243004934 acyl-activating enzyme (AAE) consensus motif; other site 243243004935 AMP binding site [chemical binding]; other site 243243004936 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243004937 Condensation domain; Region: Condensation; pfam00668 243243004938 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243004939 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243004940 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243004941 acyl-activating enzyme (AAE) consensus motif; other site 243243004942 AMP binding site [chemical binding]; other site 243243004943 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243004944 Condensation domain; Region: Condensation; pfam00668 243243004945 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243004946 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243004947 acyl-activating enzyme (AAE) consensus motif; other site 243243004948 AMP binding site [chemical binding]; other site 243243004949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243004950 MbtH-like protein; Region: MbtH; pfam03621 243243004951 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 243243004952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243004953 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 243243004954 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243004955 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243004956 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 243243004957 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 243243004958 HTH domain; Region: HTH_11; pfam08279 243243004959 chaperone protein DnaJ; Provisional; Region: PRK14278 243243004960 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243243004961 HSP70 interaction site [polypeptide binding]; other site 243243004962 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 243243004963 Zn binding sites [ion binding]; other site 243243004964 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243243004965 dimer interface [polypeptide binding]; other site 243243004966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 243243004967 RNA methyltransferase, RsmE family; Region: TIGR00046 243243004968 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 243243004969 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 243243004970 PhoH-like protein; Region: PhoH; pfam02562 243243004971 metal-binding heat shock protein; Provisional; Region: PRK00016 243243004972 Domain of unknown function DUF21; Region: DUF21; pfam01595 243243004973 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243243004974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243243004975 Transporter associated domain; Region: CorC_HlyC; smart01091 243243004976 GTPase Era; Reviewed; Region: era; PRK00089 243243004977 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 243243004978 G1 box; other site 243243004979 GTP/Mg2+ binding site [chemical binding]; other site 243243004980 Switch I region; other site 243243004981 G2 box; other site 243243004982 Switch II region; other site 243243004983 G3 box; other site 243243004984 G4 box; other site 243243004985 G5 box; other site 243243004986 KH domain; Region: KH_2; pfam07650 243243004987 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 243243004988 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243004989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243004990 catalytic residue [active] 243243004991 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 243243004992 amidase; Provisional; Region: PRK06061 243243004993 Amidase; Region: Amidase; pfam01425 243243004994 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 243243004995 Recombination protein O N terminal; Region: RecO_N; pfam11967 243243004996 Recombination protein O C terminal; Region: RecO_C; pfam02565 243243004997 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 243243004998 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 243243004999 catalytic residue [active] 243243005000 putative FPP diphosphate binding site; other site 243243005001 putative FPP binding hydrophobic cleft; other site 243243005002 dimer interface [polypeptide binding]; other site 243243005003 putative IPP diphosphate binding site; other site 243243005004 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243243005005 metal binding site 2 [ion binding]; metal-binding site 243243005006 putative DNA binding helix; other site 243243005007 metal binding site 1 [ion binding]; metal-binding site 243243005008 dimer interface [polypeptide binding]; other site 243243005009 structural Zn2+ binding site [ion binding]; other site 243243005010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243243005011 dimerization interface [polypeptide binding]; other site 243243005012 putative DNA binding site [nucleotide binding]; other site 243243005013 putative Zn2+ binding site [ion binding]; other site 243243005014 glycyl-tRNA synthetase; Provisional; Region: PRK04173 243243005015 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243243005016 motif 1; other site 243243005017 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 243243005018 active site 243243005019 motif 2; other site 243243005020 motif 3; other site 243243005021 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 243243005022 anticodon binding site; other site 243243005023 Repair protein; Region: Repair_PSII; pfam04536 243243005024 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 243243005025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243243005026 Zn2+ binding site [ion binding]; other site 243243005027 Mg2+ binding site [ion binding]; other site 243243005028 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 243243005029 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 243243005030 E-class dimer interface [polypeptide binding]; other site 243243005031 P-class dimer interface [polypeptide binding]; other site 243243005032 active site 243243005033 Cu2+ binding site [ion binding]; other site 243243005034 Zn2+ binding site [ion binding]; other site 243243005035 DNA primase; Validated; Region: dnaG; PRK05667 243243005036 CHC2 zinc finger; Region: zf-CHC2; cl17510 243243005037 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 243243005038 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 243243005039 active site 243243005040 metal binding site [ion binding]; metal-binding site 243243005041 interdomain interaction site; other site 243243005042 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 243243005043 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 243243005044 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 243243005045 Muconolactone delta-isomerase; Region: MIase; cl01992 243243005046 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243243005047 active site 243243005048 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243243005049 non-prolyl cis peptide bond; other site 243243005050 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 243243005051 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 243243005052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243005053 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243005054 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 243243005055 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243243005056 trimer interface [polypeptide binding]; other site 243243005057 active site 243243005058 substrate binding site [chemical binding]; other site 243243005059 CoA binding site [chemical binding]; other site 243243005060 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 243243005061 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243243005062 dimer interface [polypeptide binding]; other site 243243005063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243005064 catalytic residue [active] 243243005065 TQXA domain; Region: TQXA_dom; TIGR03934 243243005066 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243243005067 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 243243005068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243005069 catalytic residue [active] 243243005070 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 243243005071 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 243243005072 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243005073 Permease; Region: Permease; pfam02405 243243005074 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243005075 Permease; Region: Permease; pfam02405 243243005076 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005077 mce related protein; Region: MCE; pfam02470 243243005078 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243005079 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005080 mce related protein; Region: MCE; pfam02470 243243005081 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005082 mce related protein; Region: MCE; pfam02470 243243005083 mce related protein; Region: MCE; pfam02470 243243005084 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005085 mce related protein; Region: MCE; pfam02470 243243005086 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243005087 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005088 mce related protein; Region: MCE; pfam02470 243243005089 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 243243005090 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 243243005091 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005092 MULE transposase domain; Region: MULE; pfam10551 243243005093 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 243243005094 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 243243005095 [4Fe-4S] binding site [ion binding]; other site 243243005096 molybdopterin cofactor binding site; other site 243243005097 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 243243005098 molybdopterin cofactor binding site; other site 243243005099 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 243243005100 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 243243005101 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 243243005102 FAD binding pocket [chemical binding]; other site 243243005103 FAD binding motif [chemical binding]; other site 243243005104 catalytic residues [active] 243243005105 NAD binding pocket [chemical binding]; other site 243243005106 phosphate binding motif [ion binding]; other site 243243005107 beta-alpha-beta structure motif; other site 243243005108 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 243243005109 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 243243005110 acyl-coenzyme A oxidase; Region: PLN02636 243243005111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243005112 active site 243243005113 MarR family; Region: MarR; pfam01047 243243005114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243005115 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 243243005116 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243243005117 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 243243005118 Walker A/P-loop; other site 243243005119 ATP binding site [chemical binding]; other site 243243005120 Q-loop/lid; other site 243243005121 ABC transporter signature motif; other site 243243005122 Walker B; other site 243243005123 D-loop; other site 243243005124 H-loop/switch region; other site 243243005125 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243243005126 Walker A/P-loop; other site 243243005127 ATP binding site [chemical binding]; other site 243243005128 Q-loop/lid; other site 243243005129 ABC transporter signature motif; other site 243243005130 Walker B; other site 243243005131 D-loop; other site 243243005132 H-loop/switch region; other site 243243005133 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 243243005134 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 243243005135 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 243243005136 putative DNA binding site [nucleotide binding]; other site 243243005137 putative Zn2+ binding site [ion binding]; other site 243243005138 AsnC family; Region: AsnC_trans_reg; pfam01037 243243005139 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 243243005140 Amidinotransferase; Region: Amidinotransf; pfam02274 243243005141 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 243243005142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243243005143 inhibitor-cofactor binding pocket; inhibition site 243243005144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243005145 catalytic residue [active] 243243005146 amino acid transporter; Region: 2A0306; TIGR00909 243243005147 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 243243005148 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 243243005149 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 243243005150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 243243005151 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 243243005152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243005153 dimer interface [polypeptide binding]; other site 243243005154 conserved gate region; other site 243243005155 putative PBP binding loops; other site 243243005156 ABC-ATPase subunit interface; other site 243243005157 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 243243005158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 243243005159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243005160 dimer interface [polypeptide binding]; other site 243243005161 putative PBP binding loops; other site 243243005162 ABC-ATPase subunit interface; other site 243243005163 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 243243005164 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 243243005165 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243005166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243005167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243005168 short chain dehydrogenase; Provisional; Region: PRK06179 243243005169 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 243243005170 NADP binding site [chemical binding]; other site 243243005171 active site 243243005172 steroid binding site; other site 243243005173 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005174 MULE transposase domain; Region: MULE; pfam10551 243243005175 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243243005176 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243005177 NAD(P) binding site [chemical binding]; other site 243243005178 catalytic residues [active] 243243005179 Repair protein; Region: Repair_PSII; pfam04536 243243005180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243005181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243005182 putative substrate translocation pore; other site 243243005183 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 243243005184 catalytic triad [active] 243243005185 active site nucleophile [active] 243243005186 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243243005187 GAF domain; Region: GAF_3; pfam13492 243243005188 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243243005189 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243243005190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243005191 ATP binding site [chemical binding]; other site 243243005192 Mg2+ binding site [ion binding]; other site 243243005193 G-X-G motif; other site 243243005194 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243005195 regulatory phosphorylation site [posttranslational modification]; other site 243243005196 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243005197 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243005198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243243005199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243005200 S-adenosylmethionine binding site [chemical binding]; other site 243243005201 CCC1-related family of proteins; Region: CCC1_like; cl00278 243243005202 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 243243005203 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243005204 active site 2 [active] 243243005205 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243005206 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 243243005207 acyl-activating enzyme (AAE) consensus motif; other site 243243005208 putative AMP binding site [chemical binding]; other site 243243005209 putative active site [active] 243243005210 putative CoA binding site [chemical binding]; other site 243243005211 TIGR03085 family protein; Region: TIGR03085 243243005212 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 243243005213 heat shock protein 90; Provisional; Region: PRK05218 243243005214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243005215 ATP binding site [chemical binding]; other site 243243005216 Mg2+ binding site [ion binding]; other site 243243005217 G-X-G motif; other site 243243005218 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243005219 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243005220 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 243243005221 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243243005222 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 243243005223 MgtE intracellular N domain; Region: MgtE_N; smart00924 243243005224 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 243243005225 PknH-like extracellular domain; Region: PknH_C; pfam14032 243243005226 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 243243005227 dimer interface [polypeptide binding]; other site 243243005228 ligand binding site [chemical binding]; other site 243243005229 Predicted membrane protein [Function unknown]; Region: COG4270 243243005230 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243005231 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 243243005232 dimer interface [polypeptide binding]; other site 243243005233 active site 243243005234 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243243005235 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 243243005236 active site 243243005237 haloalkane dehalogenase; Provisional; Region: PRK00870 243243005238 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 243243005239 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 243243005240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243005241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243005242 homodimer interface [polypeptide binding]; other site 243243005243 catalytic residue [active] 243243005244 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243005245 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 243243005246 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243005247 Cytochrome P450; Region: p450; cl12078 243243005248 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243005249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243005250 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243243005251 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 243243005252 active site residue [active] 243243005253 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 243243005254 active site residue [active] 243243005255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243005256 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 243243005257 Predicted ATPase [General function prediction only]; Region: COG4637 243243005258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243005259 Walker A/P-loop; other site 243243005260 ATP binding site [chemical binding]; other site 243243005261 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 243243005262 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 243243005263 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243005264 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243005265 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243005266 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 243243005267 HicB family; Region: HicB; pfam05534 243243005268 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005269 MULE transposase domain; Region: MULE; pfam10551 243243005270 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 243243005271 4Fe-4S binding domain; Region: Fer4; cl02805 243243005272 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243243005273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243005274 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 243243005275 dimerization interface [polypeptide binding]; other site 243243005276 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 243243005277 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 243243005278 putative active site [active] 243243005279 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 243243005280 putative active site [active] 243243005281 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 243243005282 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243243005283 Active Sites [active] 243243005284 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 243243005285 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243243005286 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243243005287 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243005288 Cytochrome P450; Region: p450; cl12078 243243005289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243005290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243005291 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243005292 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243243005293 active site 243243005294 ATP binding site [chemical binding]; other site 243243005295 substrate binding site [chemical binding]; other site 243243005296 activation loop (A-loop); other site 243243005297 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243005298 Cytochrome P450; Region: p450; cl12078 243243005299 Transposase; Region: HTH_Tnp_1; cl17663 243243005300 putative transposase OrfB; Reviewed; Region: PHA02517 243243005301 HTH-like domain; Region: HTH_21; pfam13276 243243005302 Integrase core domain; Region: rve; pfam00665 243243005303 Integrase core domain; Region: rve_3; cl15866 243243005304 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005305 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243243005306 active site 243243005307 ATP binding site [chemical binding]; other site 243243005308 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243005309 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243005310 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243005311 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243005312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243005313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243005314 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243005315 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243005316 active site 243243005317 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 243243005318 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 243243005319 active site 243243005320 metal binding site [ion binding]; metal-binding site 243243005321 Cutinase; Region: Cutinase; pfam01083 243243005322 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243005323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243005324 Septum formation; Region: Septum_form; pfam13845 243243005325 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 243243005326 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243005327 Cytochrome P450; Region: p450; cl12078 243243005328 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243005329 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243005330 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243243005331 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243243005332 nucleotide binding site [chemical binding]; other site 243243005333 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 243243005334 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243005335 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243243005336 Methyltransferase domain; Region: Methyltransf_12; pfam08242 243243005337 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243243005338 Beta-lactamase; Region: Beta-lactamase; pfam00144 243243005339 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 243243005340 diacylglycerol kinase; Reviewed; Region: PRK11914 243243005341 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 243243005342 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243243005343 FAD binding domain; Region: FAD_binding_4; pfam01565 243243005344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243005345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243005346 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 243243005347 FAD binding domain; Region: FAD_binding_3; pfam01494 243243005348 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243005349 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243243005350 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 243243005351 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 243243005352 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 243243005353 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243243005354 dimer interface [polypeptide binding]; other site 243243005355 active site 243243005356 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 243243005357 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243243005358 dimer interface [polypeptide binding]; other site 243243005359 active site 243243005360 acyl carrier protein; Provisional; Region: acpP; PRK00982 243243005361 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243243005362 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243243005363 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 243243005364 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 243243005365 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 243243005366 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 243243005367 dimer interface [polypeptide binding]; other site 243243005368 TPP-binding site [chemical binding]; other site 243243005369 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 243243005370 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243243005371 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 243243005372 dimer interface [polypeptide binding]; other site 243243005373 catalytic triad [active] 243243005374 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 243243005375 Epoxide hydrolase N terminus; Region: EHN; pfam06441 243243005376 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243005377 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 243243005378 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 243243005379 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 243243005380 Low molecular weight phosphatase family; Region: LMWPc; cd00115 243243005381 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 243243005382 active site 243243005383 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 243243005384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243005385 motif II; other site 243243005386 hypothetical protein; Provisional; Region: PRK07908 243243005387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243005388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243005389 homodimer interface [polypeptide binding]; other site 243243005390 catalytic residue [active] 243243005391 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 243243005392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 243243005393 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 243243005394 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 243243005395 5' nucleotidase family; Region: 5_nucleotid; cl17687 243243005396 Putative zinc ribbon domain; Region: DUF164; pfam02591 243243005397 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 243243005398 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 243243005399 RNA/DNA hybrid binding site [nucleotide binding]; other site 243243005400 active site 243243005401 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243005402 catalytic core [active] 243243005403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243005404 Cytochrome P450; Region: p450; cl12078 243243005405 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243243005406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243005407 sequence-specific DNA binding site [nucleotide binding]; other site 243243005408 salt bridge; other site 243243005409 Cupin domain; Region: Cupin_2; pfam07883 243243005410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243005411 S-adenosylmethionine binding site [chemical binding]; other site 243243005412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 243243005413 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 243243005414 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 243243005415 Int/Topo IB signature motif; other site 243243005416 Helix-turn-helix domain; Region: HTH_17; pfam12728 243243005417 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005418 MULE transposase domain; Region: MULE; pfam10551 243243005419 Integrase core domain; Region: rve; pfam00665 243243005420 Integrase core domain; Region: rve_3; cl15866 243243005421 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005422 MULE transposase domain; Region: MULE; pfam10551 243243005423 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 243243005424 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005425 MULE transposase domain; Region: MULE; pfam10551 243243005426 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005427 MULE transposase domain; Region: MULE; pfam10551 243243005428 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005429 MULE transposase domain; Region: MULE; pfam10551 243243005430 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005431 MULE transposase domain; Region: MULE; pfam10551 243243005432 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005433 Divergent AAA domain; Region: AAA_4; pfam04326 243243005434 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005435 MULE transposase domain; Region: MULE; pfam10551 243243005436 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 243243005437 putative active site; other site 243243005438 putative metal binding residues [ion binding]; other site 243243005439 signature motif; other site 243243005440 putative triphosphate binding site [ion binding]; other site 243243005441 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 243243005442 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 243243005443 oligomerization interface [polypeptide binding]; other site 243243005444 active site 243243005445 metal binding site [ion binding]; metal-binding site 243243005446 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243005447 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243005448 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 243243005449 TAP-like protein; Region: Abhydrolase_4; pfam08386 243243005450 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 243243005451 TAP-like protein; Region: Abhydrolase_4; pfam08386 243243005452 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 243243005453 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 243243005454 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243243005455 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 243243005456 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243243005457 metal binding triad; other site 243243005458 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243243005459 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243243005460 metal binding triad; other site 243243005461 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243243005462 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243005463 CoenzymeA binding site [chemical binding]; other site 243243005464 subunit interaction site [polypeptide binding]; other site 243243005465 PHB binding site; other site 243243005466 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243005467 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243005468 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005469 MULE transposase domain; Region: MULE; pfam10551 243243005470 Transposase; Region: HTH_Tnp_1; cl17663 243243005471 putative transposase OrfB; Reviewed; Region: PHA02517 243243005472 HTH-like domain; Region: HTH_21; pfam13276 243243005473 Integrase core domain; Region: rve; pfam00665 243243005474 Integrase core domain; Region: rve_3; cl15866 243243005475 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243243005476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243005477 non-specific DNA binding site [nucleotide binding]; other site 243243005478 salt bridge; other site 243243005479 sequence-specific DNA binding site [nucleotide binding]; other site 243243005480 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243005481 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243243005482 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243005483 active site 243243005484 DNA binding site [nucleotide binding] 243243005485 Int/Topo IB signature motif; other site 243243005486 glutamine synthetase, type I; Region: GlnA; TIGR00653 243243005487 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 243243005488 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243243005489 RDD family; Region: RDD; pfam06271 243243005490 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 243243005491 lipoyl synthase; Provisional; Region: PRK05481 243243005492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243243005493 FeS/SAM binding site; other site 243243005494 lipoate-protein ligase B; Provisional; Region: PRK14345 243243005495 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 243243005496 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 243243005497 putative NAD(P) binding site [chemical binding]; other site 243243005498 putative active site [active] 243243005499 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243243005500 E3 interaction surface; other site 243243005501 lipoyl attachment site [posttranslational modification]; other site 243243005502 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243243005503 E3 interaction surface; other site 243243005504 lipoyl attachment site [posttranslational modification]; other site 243243005505 e3 binding domain; Region: E3_binding; pfam02817 243243005506 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 243243005507 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243243005508 short chain dehydrogenase; Validated; Region: PRK05855 243243005509 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243005510 classical (c) SDRs; Region: SDR_c; cd05233 243243005511 NAD(P) binding site [chemical binding]; other site 243243005512 active site 243243005513 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 243243005514 hydrophobic ligand binding site; other site 243243005515 multifunctional aminopeptidase A; Provisional; Region: PRK00913 243243005516 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 243243005517 interface (dimer of trimers) [polypeptide binding]; other site 243243005518 Substrate-binding/catalytic site; other site 243243005519 Zn-binding sites [ion binding]; other site 243243005520 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 243243005521 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243243005522 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 243243005523 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 243243005524 homodimer interface [polypeptide binding]; other site 243243005525 substrate-cofactor binding pocket; other site 243243005526 catalytic residue [active] 243243005527 cobalamin synthase; Reviewed; Region: cobS; PRK00235 243243005528 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 243243005529 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 243243005530 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 243243005531 putative dimer interface [polypeptide binding]; other site 243243005532 active site pocket [active] 243243005533 putative cataytic base [active] 243243005534 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 243243005535 homotrimer interface [polypeptide binding]; other site 243243005536 Walker A motif; other site 243243005537 GTP binding site [chemical binding]; other site 243243005538 Walker B motif; other site 243243005539 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 243243005540 Glycerate kinase family; Region: Gly_kinase; pfam02595 243243005541 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 243243005542 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 243243005543 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243243005544 substrate binding site [chemical binding]; other site 243243005545 ATP binding site [chemical binding]; other site 243243005546 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 243243005547 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243243005548 dimer interface [polypeptide binding]; other site 243243005549 active site 243243005550 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243243005551 Ligand Binding Site [chemical binding]; other site 243243005552 Molecular Tunnel; other site 243243005553 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 243243005554 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243243005555 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 243243005556 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243005557 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 243243005558 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 243243005559 heme bH binding site [chemical binding]; other site 243243005560 intrachain domain interface; other site 243243005561 heme bL binding site [chemical binding]; other site 243243005562 interchain domain interface [polypeptide binding]; other site 243243005563 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 243243005564 Qo binding site; other site 243243005565 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 243243005566 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 243243005567 iron-sulfur cluster [ion binding]; other site 243243005568 [2Fe-2S] cluster binding site [ion binding]; other site 243243005569 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243243005570 Cytochrome c; Region: Cytochrom_C; pfam00034 243243005571 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243243005572 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 243243005573 Subunit I/III interface [polypeptide binding]; other site 243243005574 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 243243005575 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243243005576 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243243005577 hypothetical protein; Validated; Region: PRK07883 243243005578 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 243243005579 active site 243243005580 substrate binding site [chemical binding]; other site 243243005581 catalytic site [active] 243243005582 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243243005583 GIY-YIG motif/motif A; other site 243243005584 active site 243243005585 catalytic site [active] 243243005586 putative DNA binding site [nucleotide binding]; other site 243243005587 metal binding site [ion binding]; metal-binding site 243243005588 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243243005589 NlpC/P60 family; Region: NLPC_P60; pfam00877 243243005590 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 243243005591 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243243005592 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243005593 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 243243005594 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 243243005595 acyl-activating enzyme (AAE) consensus motif; other site 243243005596 putative AMP binding site [chemical binding]; other site 243243005597 putative active site [active] 243243005598 putative CoA binding site [chemical binding]; other site 243243005599 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 243243005600 putative hydrophobic ligand binding site [chemical binding]; other site 243243005601 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 243243005602 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 243243005603 DTAP/Switch II; other site 243243005604 Switch I; other site 243243005605 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243005606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243243005607 putative acyl-acceptor binding pocket; other site 243243005608 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 243243005609 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 243243005610 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 243243005611 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243005612 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243243005613 active site 243243005614 ATP binding site [chemical binding]; other site 243243005615 substrate binding site [chemical binding]; other site 243243005616 activation loop (A-loop); other site 243243005617 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 243243005618 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243243005619 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243243005620 substrate binding pocket [chemical binding]; other site 243243005621 chain length determination region; other site 243243005622 substrate-Mg2+ binding site; other site 243243005623 catalytic residues [active] 243243005624 aspartate-rich region 1; other site 243243005625 active site lid residues [active] 243243005626 aspartate-rich region 2; other site 243243005627 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 243243005628 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243243005629 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 243243005630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 243243005631 MraZ protein; Region: MraZ; pfam02381 243243005632 MraZ protein; Region: MraZ; pfam02381 243243005633 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 243243005634 MraW methylase family; Region: Methyltransf_5; cl17771 243243005635 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243243005636 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243243005637 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243243005638 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 243243005639 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243243005640 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243243005641 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243243005642 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243243005643 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243243005644 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 243243005645 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 243243005646 Mg++ binding site [ion binding]; other site 243243005647 putative catalytic motif [active] 243243005648 putative substrate binding site [chemical binding]; other site 243243005649 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 243243005650 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243243005651 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243243005652 cell division protein FtsW; Region: ftsW; TIGR02614 243243005653 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 243243005654 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 243243005655 active site 243243005656 homodimer interface [polypeptide binding]; other site 243243005657 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 243243005658 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243243005659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243243005660 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243243005661 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 243243005662 Cell division protein FtsQ; Region: FtsQ; pfam03799 243243005663 cell division protein FtsZ; Validated; Region: PRK09330 243243005664 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 243243005665 nucleotide binding site [chemical binding]; other site 243243005666 SulA interaction site; other site 243243005667 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 243243005668 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 243243005669 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 243243005670 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243243005671 catalytic residue [active] 243243005672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 243243005673 Predicted integral membrane protein [Function unknown]; Region: COG0762 243243005674 DivIVA domain; Region: DivI1A_domain; TIGR03544 243243005675 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 243243005676 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 243243005677 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243243005678 active site 243243005679 aconitate hydratase; Validated; Region: PRK07229 243243005680 hypothetical protein; Provisional; Region: PRK07906 243243005681 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 243243005682 putative metal binding site [ion binding]; other site 243243005683 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243243005684 substrate binding site [chemical binding]; other site 243243005685 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243005686 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243005687 active site 243243005688 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 243243005689 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 243243005690 quinone interaction residues [chemical binding]; other site 243243005691 active site 243243005692 catalytic residues [active] 243243005693 FMN binding site [chemical binding]; other site 243243005694 substrate binding site [chemical binding]; other site 243243005695 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243005696 catalytic core [active] 243243005697 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 243243005698 conserved hypothetical protein; Region: TIGR03843 243243005699 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 243243005700 active site 243243005701 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 243243005702 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243243005703 active site 243243005704 HIGH motif; other site 243243005705 nucleotide binding site [chemical binding]; other site 243243005706 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243243005707 active site 243243005708 KMSKS motif; other site 243243005709 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 243243005710 putative tRNA binding surface [nucleotide binding]; other site 243243005711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243005712 Walker A motif; other site 243243005713 ATP binding site [chemical binding]; other site 243243005714 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243243005715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243243005716 DNA binding residues [nucleotide binding] 243243005717 dimerization interface [polypeptide binding]; other site 243243005718 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243005719 MULE transposase domain; Region: MULE; pfam10551 243243005720 AAA ATPase domain; Region: AAA_16; pfam13191 243243005721 AAA domain; Region: AAA_22; pfam13401 243243005722 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243243005723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243243005724 DNA binding residues [nucleotide binding] 243243005725 dimerization interface [polypeptide binding]; other site 243243005726 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 243243005727 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243243005728 PYR/PP interface [polypeptide binding]; other site 243243005729 dimer interface [polypeptide binding]; other site 243243005730 TPP binding site [chemical binding]; other site 243243005731 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243243005732 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 243243005733 TPP-binding site [chemical binding]; other site 243243005734 MbtH-like protein; Region: MbtH; pfam03621 243243005735 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243243005736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243005737 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243243005738 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243005739 active site 243243005740 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 243243005741 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243243005742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243005743 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243243005744 Enoylreductase; Region: PKS_ER; smart00829 243243005745 NAD(P) binding site [chemical binding]; other site 243243005746 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 243243005747 KR domain; Region: KR; pfam08659 243243005748 putative NADP binding site [chemical binding]; other site 243243005749 active site 243243005750 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243005751 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243005752 Cytochrome P450; Region: p450; cl12078 243243005753 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 243243005754 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 243243005755 FAD binding pocket [chemical binding]; other site 243243005756 FAD binding motif [chemical binding]; other site 243243005757 phosphate binding motif [ion binding]; other site 243243005758 NAD binding pocket [chemical binding]; other site 243243005759 short chain dehydrogenase; Provisional; Region: PRK05872 243243005760 classical (c) SDRs; Region: SDR_c; cd05233 243243005761 NAD(P) binding site [chemical binding]; other site 243243005762 active site 243243005763 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 243243005764 Winged helix-turn helix; Region: HTH_29; pfam13551 243243005765 Integrase core domain; Region: rve; pfam00665 243243005766 Integrase core domain; Region: rve_3; pfam13683 243243005767 PAC2 family; Region: PAC2; pfam09754 243243005768 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 243243005769 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 243243005770 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 243243005771 substrate binding pocket [chemical binding]; other site 243243005772 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 243243005773 B12 binding site [chemical binding]; other site 243243005774 cobalt ligand [ion binding]; other site 243243005775 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 243243005776 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 243243005777 Winged helix-turn helix; Region: HTH_29; pfam13551 243243005778 Integrase core domain; Region: rve; pfam00665 243243005779 Integrase core domain; Region: rve_3; pfam13683 243243005780 Mannan-binding protein; Region: MVL; pfam12151 243243005781 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005782 mce related protein; Region: MCE; pfam02470 243243005783 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005784 mce related protein; Region: MCE; pfam02470 243243005785 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005786 mce related protein; Region: MCE; pfam02470 243243005787 mce related protein; Region: MCE; pfam02470 243243005788 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005789 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243005790 mce related protein; Region: MCE; pfam02470 243243005791 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243243005792 mce related protein; Region: MCE; pfam02470 243243005793 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243005794 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243005795 Permease; Region: Permease; pfam02405 243243005796 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243005797 Permease; Region: Permease; pfam02405 243243005798 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243005799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243005800 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 243243005801 homodimer interface [polypeptide binding]; other site 243243005802 putative metal binding site [ion binding]; other site 243243005803 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 243243005804 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 243243005805 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 243243005806 Predicted membrane protein [Function unknown]; Region: COG3918 243243005807 mercuric reductase; Validated; Region: PRK06370 243243005808 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243005809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243005810 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243243005811 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 243243005812 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 243243005813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243005814 S-adenosylmethionine binding site [chemical binding]; other site 243243005815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 243243005816 proteasome ATPase; Region: pup_AAA; TIGR03689 243243005817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243005818 Walker A motif; other site 243243005819 ATP binding site [chemical binding]; other site 243243005820 Walker B motif; other site 243243005821 arginine finger; other site 243243005822 Pup-like protein; Region: Pup; pfam05639 243243005823 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 243243005824 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 243243005825 active site 243243005826 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 243243005827 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 243243005828 active site 243243005829 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 243243005830 Predicted transcriptional regulator [Transcription]; Region: COG2378 243243005831 WYL domain; Region: WYL; pfam13280 243243005832 Predicted transcriptional regulator [Transcription]; Region: COG2378 243243005833 WYL domain; Region: WYL; pfam13280 243243005834 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 243243005835 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 243243005836 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 243243005837 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 243243005838 5'-3' exonuclease; Region: 53EXOc; smart00475 243243005839 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 243243005840 active site 243243005841 metal binding site 1 [ion binding]; metal-binding site 243243005842 putative 5' ssDNA interaction site; other site 243243005843 metal binding site 3; metal-binding site 243243005844 metal binding site 2 [ion binding]; metal-binding site 243243005845 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 243243005846 putative DNA binding site [nucleotide binding]; other site 243243005847 putative metal binding site [ion binding]; other site 243243005848 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243243005849 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243243005850 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 243243005851 active site 243243005852 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 243243005853 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 243243005854 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 243243005855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243005856 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243243005857 NAD(P) binding site [chemical binding]; other site 243243005858 active site 243243005859 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 243243005860 active site 243243005861 putative homodimer interface [polypeptide binding]; other site 243243005862 SAM binding site [chemical binding]; other site 243243005863 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 243243005864 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 243243005865 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 243243005866 active site 243243005867 SAM binding site [chemical binding]; other site 243243005868 homodimer interface [polypeptide binding]; other site 243243005869 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 243243005870 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 243243005871 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 243243005872 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 243243005873 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243005874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243005875 DNA binding residues [nucleotide binding] 243243005876 PPE family; Region: PPE; pfam00823 243243005877 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243005878 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 243243005879 active site 243243005880 SAM binding site [chemical binding]; other site 243243005881 homodimer interface [polypeptide binding]; other site 243243005882 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 243243005883 active site 243243005884 SAM binding site [chemical binding]; other site 243243005885 homodimer interface [polypeptide binding]; other site 243243005886 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 243243005887 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 243243005888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243005889 dimer interface [polypeptide binding]; other site 243243005890 conserved gate region; other site 243243005891 putative PBP binding loops; other site 243243005892 ABC-ATPase subunit interface; other site 243243005893 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243243005894 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243243005895 Walker A/P-loop; other site 243243005896 ATP binding site [chemical binding]; other site 243243005897 Q-loop/lid; other site 243243005898 ABC transporter signature motif; other site 243243005899 Walker B; other site 243243005900 D-loop; other site 243243005901 H-loop/switch region; other site 243243005902 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 243243005903 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243243005904 substrate binding pocket [chemical binding]; other site 243243005905 membrane-bound complex binding site; other site 243243005906 hinge residues; other site 243243005907 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243243005908 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243005909 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 243243005910 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 243243005911 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 243243005912 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243005913 classical (c) SDRs; Region: SDR_c; cd05233 243243005914 NAD(P) binding site [chemical binding]; other site 243243005915 active site 243243005916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243005917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243005918 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 243243005919 Dienelactone hydrolase family; Region: DLH; pfam01738 243243005920 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 243243005921 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 243243005922 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 243243005923 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243005924 active site 243243005925 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 243243005926 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243243005927 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243005928 active site 243243005929 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243005930 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243243005931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243005932 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243243005933 Enoylreductase; Region: PKS_ER; smart00829 243243005934 NAD(P) binding site [chemical binding]; other site 243243005935 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 243243005936 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243243005937 putative NADP binding site [chemical binding]; other site 243243005938 active site 243243005939 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243005940 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243243005941 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243005942 active site 243243005943 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243005944 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243243005945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243005946 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243243005947 Enoylreductase; Region: PKS_ER; smart00829 243243005948 NAD(P) binding site [chemical binding]; other site 243243005949 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 243243005950 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243243005951 putative NADP binding site [chemical binding]; other site 243243005952 active site 243243005953 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243005954 hypothetical protein; Provisional; Region: PRK05865 243243005955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243005956 NAD(P) binding site [chemical binding]; other site 243243005957 active site 243243005958 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243243005959 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243243005960 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 243243005961 Walker A motif; other site 243243005962 ATP binding site [chemical binding]; other site 243243005963 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 243243005964 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243243005965 metal ion-dependent adhesion site (MIDAS); other site 243243005966 short chain dehydrogenase; Provisional; Region: PRK07814 243243005967 classical (c) SDRs; Region: SDR_c; cd05233 243243005968 NAD(P) binding site [chemical binding]; other site 243243005969 active site 243243005970 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243005971 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243243005972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243005973 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243005974 Cytochrome P450; Region: p450; cl12078 243243005975 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 243243005976 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243005977 substrate binding pocket [chemical binding]; other site 243243005978 catalytic triad [active] 243243005979 Phosphotransferase enzyme family; Region: APH; pfam01636 243243005980 Ecdysteroid kinase; Region: EcKinase; cl17738 243243005981 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 243243005982 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 243243005983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 243243005984 AAA domain; Region: AAA_33; pfam13671 243243005985 Predicted membrane protein [Function unknown]; Region: COG2259 243243005986 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 243243005987 Isochorismatase family; Region: Isochorismatase; pfam00857 243243005988 catalytic triad [active] 243243005989 conserved cis-peptide bond; other site 243243005990 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 243243005991 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 243243005992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243005993 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 243243005994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 243243005995 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 243243005996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243005997 dimer interface [polypeptide binding]; other site 243243005998 conserved gate region; other site 243243005999 putative PBP binding loops; other site 243243006000 ABC-ATPase subunit interface; other site 243243006001 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 243243006002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243006003 dimer interface [polypeptide binding]; other site 243243006004 conserved gate region; other site 243243006005 putative PBP binding loops; other site 243243006006 ABC-ATPase subunit interface; other site 243243006007 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 243243006008 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 243243006009 Walker A/P-loop; other site 243243006010 ATP binding site [chemical binding]; other site 243243006011 Q-loop/lid; other site 243243006012 ABC transporter signature motif; other site 243243006013 Walker B; other site 243243006014 D-loop; other site 243243006015 H-loop/switch region; other site 243243006016 TOBE domain; Region: TOBE_2; pfam08402 243243006017 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 243243006018 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243243006019 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 243243006020 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 243243006021 Iron permease FTR1 family; Region: FTR1; cl00475 243243006022 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 243243006023 Imelysin; Region: Peptidase_M75; pfam09375 243243006024 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 243243006025 OsmC-like protein; Region: OsmC; pfam02566 243243006026 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006027 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006028 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243006029 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 243243006030 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 243243006031 putative transposase OrfB; Reviewed; Region: PHA02517 243243006032 HTH-like domain; Region: HTH_21; pfam13276 243243006033 Integrase core domain; Region: rve; pfam00665 243243006034 Integrase core domain; Region: rve_3; cl15866 243243006035 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243243006036 Ligand Binding Site [chemical binding]; other site 243243006037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243006038 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243006039 active site 243243006040 catalytic tetrad [active] 243243006041 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243006042 extended (e) SDRs; Region: SDR_e; cd08946 243243006043 NAD(P) binding site [chemical binding]; other site 243243006044 active site 243243006045 substrate binding site [chemical binding]; other site 243243006046 SnoaL-like domain; Region: SnoaL_4; pfam13577 243243006047 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 243243006048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006050 active site 243243006051 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 243243006052 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 243243006053 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 243243006054 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 243243006055 dimer interface [polypeptide binding]; other site 243243006056 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 243243006057 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243243006058 Ligand Binding Site [chemical binding]; other site 243243006059 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243243006060 Ligand Binding Site [chemical binding]; other site 243243006061 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243243006062 Ligand Binding Site [chemical binding]; other site 243243006063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243243006064 PAS domain; Region: PAS_9; pfam13426 243243006065 putative active site [active] 243243006066 heme pocket [chemical binding]; other site 243243006067 PAS domain S-box; Region: sensory_box; TIGR00229 243243006068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243243006069 putative active site [active] 243243006070 heme pocket [chemical binding]; other site 243243006071 Histidine kinase; Region: HisKA_3; pfam07730 243243006072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243006073 Mg2+ binding site [ion binding]; other site 243243006074 G-X-G motif; other site 243243006075 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 243243006076 homotetramer interface [polypeptide binding]; other site 243243006077 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243006078 NAD binding site [chemical binding]; other site 243243006079 homodimer interface [polypeptide binding]; other site 243243006080 active site 243243006081 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 243243006082 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243006083 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243006084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006085 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243006086 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243006087 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243006088 PPE family; Region: PPE; pfam00823 243243006089 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243006090 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 243243006091 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 243243006092 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 243243006093 active site 243243006094 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 243243006095 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 243243006096 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243006097 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243006098 MULE transposase domain; Region: MULE; pfam10551 243243006099 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 243243006100 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 243243006101 tetrameric interface [polypeptide binding]; other site 243243006102 NAD binding site [chemical binding]; other site 243243006103 catalytic residues [active] 243243006104 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 243243006105 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 243243006106 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243006107 MULE transposase domain; Region: MULE; pfam10551 243243006108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 243243006111 Integrase core domain; Region: rve; pfam00665 243243006112 transposase; Provisional; Region: PRK06526 243243006113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243006114 Walker A motif; other site 243243006115 ATP binding site [chemical binding]; other site 243243006116 Walker B motif; other site 243243006117 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243006118 Permease; Region: Permease; pfam02405 243243006119 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243006120 Permease; Region: Permease; pfam02405 243243006121 mce related protein; Region: MCE; pfam02470 243243006122 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243006123 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243006124 mce related protein; Region: MCE; pfam02470 243243006125 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243006126 mce related protein; Region: MCE; pfam02470 243243006127 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243006128 mce related protein; Region: MCE; pfam02470 243243006129 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243006130 mce related protein; Region: MCE; pfam02470 243243006131 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243006132 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243006133 mce related protein; Region: MCE; pfam02470 243243006134 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 243243006135 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 243243006136 active site 243243006137 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 243243006138 catalytic triad [active] 243243006139 dimer interface [polypeptide binding]; other site 243243006140 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006141 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006142 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243243006143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243006144 DNA-binding site [nucleotide binding]; DNA binding site 243243006145 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 243243006146 5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555 243243006147 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243006148 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243006149 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243006150 [2Fe-2S] cluster binding site [ion binding]; other site 243243006151 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243243006152 hydrophobic ligand binding site; other site 243243006153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006155 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 243243006156 conserved cis-peptide bond; other site 243243006157 acyl-CoA synthetase; Provisional; Region: PRK13391 243243006158 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006159 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243006160 acyl-activating enzyme (AAE) consensus motif; other site 243243006161 putative AMP binding site [chemical binding]; other site 243243006162 putative active site [active] 243243006163 putative CoA binding site [chemical binding]; other site 243243006164 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243006165 Cytochrome P450; Region: p450; cl12078 243243006166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006167 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243006168 NAD(P) binding site [chemical binding]; other site 243243006169 active site 243243006170 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243006171 classical (c) SDRs; Region: SDR_c; cd05233 243243006172 NAD(P) binding site [chemical binding]; other site 243243006173 active site 243243006174 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243006175 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006176 substrate binding site [chemical binding]; other site 243243006177 oxyanion hole (OAH) forming residues; other site 243243006178 trimer interface [polypeptide binding]; other site 243243006179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243006181 NAD(P) binding site [chemical binding]; other site 243243006182 active site 243243006183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006185 active site 243243006186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006187 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006188 active site 243243006189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006190 NAD(P) binding site [chemical binding]; other site 243243006191 active site 243243006192 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243006193 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 243243006194 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243006195 active site 243243006196 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243006197 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006198 substrate binding site [chemical binding]; other site 243243006199 oxyanion hole (OAH) forming residues; other site 243243006200 trimer interface [polypeptide binding]; other site 243243006201 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 243243006202 active site 2 [active] 243243006203 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243243006204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243006205 DNA-binding site [nucleotide binding]; DNA binding site 243243006206 FCD domain; Region: FCD; pfam07729 243243006207 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006208 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006209 active site 243243006210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006211 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006213 active site 243243006214 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 243243006215 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 243243006216 NAD binding site [chemical binding]; other site 243243006217 catalytic residues [active] 243243006218 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006219 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006220 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243006221 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243243006222 active site 243243006223 metal binding site [ion binding]; metal-binding site 243243006224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006225 NAD(P) binding site [chemical binding]; other site 243243006226 active site 243243006227 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 243243006228 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006229 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243006230 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243243006231 active site 243243006232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006234 active site 243243006235 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243006236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006237 acyl-activating enzyme (AAE) consensus motif; other site 243243006238 AMP binding site [chemical binding]; other site 243243006239 active site 243243006240 CoA binding site [chemical binding]; other site 243243006241 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243006242 Cytochrome P450; Region: p450; cl12078 243243006243 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 243243006244 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243006245 active site 243243006246 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243243006247 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243006248 acyl-activating enzyme (AAE) consensus motif; other site 243243006249 putative AMP binding site [chemical binding]; other site 243243006250 putative active site [active] 243243006251 putative CoA binding site [chemical binding]; other site 243243006252 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243006253 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243006254 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243006255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006257 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243243006258 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 243243006259 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243006260 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243006261 putative acyltransferase; Provisional; Region: PRK05790 243243006262 dimer interface [polypeptide binding]; other site 243243006263 active site 243243006264 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 243243006265 putative active site [active] 243243006266 putative catalytic site [active] 243243006267 lipid-transfer protein; Provisional; Region: PRK07855 243243006268 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243006269 active site 243243006270 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243243006271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006272 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243006273 acyl-activating enzyme (AAE) consensus motif; other site 243243006274 putative AMP binding site [chemical binding]; other site 243243006275 putative active site [active] 243243006276 putative CoA binding site [chemical binding]; other site 243243006277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006281 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243006282 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006284 active site 243243006285 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243243006286 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006287 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006288 active site 243243006289 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243006290 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006292 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006293 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006294 active site 243243006295 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243006296 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006297 active site 243243006298 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006299 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243006300 acyl-activating enzyme (AAE) consensus motif; other site 243243006301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006302 AMP binding site [chemical binding]; other site 243243006303 active site 243243006304 acyl-activating enzyme (AAE) consensus motif; other site 243243006305 CoA binding site [chemical binding]; other site 243243006306 enoyl-CoA hydratase; Provisional; Region: PRK08252 243243006307 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006308 substrate binding site [chemical binding]; other site 243243006309 oxyanion hole (OAH) forming residues; other site 243243006310 trimer interface [polypeptide binding]; other site 243243006311 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243006312 classical (c) SDRs; Region: SDR_c; cd05233 243243006313 NAD(P) binding site [chemical binding]; other site 243243006314 active site 243243006315 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243006316 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243006317 active site 2 [active] 243243006318 active site 1 [active] 243243006319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006321 active site 243243006322 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243006323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006324 substrate binding site [chemical binding]; other site 243243006325 oxyanion hole (OAH) forming residues; other site 243243006326 trimer interface [polypeptide binding]; other site 243243006327 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243006328 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 243243006329 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 243243006330 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243006331 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243006332 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243006333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006335 active site 243243006336 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 243243006337 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243006338 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 243243006339 NAD(P) binding site [chemical binding]; other site 243243006340 catalytic residues [active] 243243006341 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006342 enoyl-CoA hydratase; Provisional; Region: PRK07799 243243006343 substrate binding site [chemical binding]; other site 243243006344 oxyanion hole (OAH) forming residues; other site 243243006345 trimer interface [polypeptide binding]; other site 243243006346 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243243006347 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006348 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243006349 acyl-activating enzyme (AAE) consensus motif; other site 243243006350 putative AMP binding site [chemical binding]; other site 243243006351 putative active site [active] 243243006352 putative CoA binding site [chemical binding]; other site 243243006353 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 243243006354 inter-subunit interface; other site 243243006355 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243006356 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243243006357 iron-sulfur cluster [ion binding]; other site 243243006358 [2Fe-2S] cluster binding site [ion binding]; other site 243243006359 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 243243006360 putative alpha subunit interface [polypeptide binding]; other site 243243006361 putative active site [active] 243243006362 putative substrate binding site [chemical binding]; other site 243243006363 Fe binding site [ion binding]; other site 243243006364 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243006365 thiolase; Provisional; Region: PRK06158 243243006366 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243006367 active site 243243006368 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243006369 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 243243006370 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 243243006371 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 243243006372 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006373 active site 243243006374 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006375 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243006376 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006377 active site 243243006378 thiolase; Provisional; Region: PRK06158 243243006379 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243006380 active site 243243006381 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243006382 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006383 acyl-activating enzyme (AAE) consensus motif; other site 243243006384 AMP binding site [chemical binding]; other site 243243006385 active site 243243006386 CoA binding site [chemical binding]; other site 243243006387 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243006388 classical (c) SDRs; Region: SDR_c; cd05233 243243006389 NAD(P) binding site [chemical binding]; other site 243243006390 active site 243243006391 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243006392 active site 1 [active] 243243006393 active site 2 [active] 243243006394 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006395 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006396 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006397 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006400 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243006401 MULE transposase domain; Region: MULE; pfam10551 243243006402 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243006403 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243006404 lipid-transfer protein; Provisional; Region: PRK07855 243243006405 active site 243243006406 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243006407 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243006408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006410 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243006411 Cytochrome P450; Region: p450; cl12078 243243006412 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 243243006413 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243006414 classical (c) SDRs; Region: SDR_c; cd05233 243243006415 NAD(P) binding site [chemical binding]; other site 243243006416 active site 243243006417 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 243243006418 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 243243006419 acyl-activating enzyme (AAE) consensus motif; other site 243243006420 putative AMP binding site [chemical binding]; other site 243243006421 putative active site [active] 243243006422 putative CoA binding site [chemical binding]; other site 243243006423 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243006424 short chain dehydrogenase; Provisional; Region: PRK07791 243243006425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006426 NAD(P) binding site [chemical binding]; other site 243243006427 active site 243243006428 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 243243006429 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243006430 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243006431 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243006432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006433 substrate binding site [chemical binding]; other site 243243006434 oxyanion hole (OAH) forming residues; other site 243243006435 trimer interface [polypeptide binding]; other site 243243006436 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243006437 Cytochrome P450; Region: p450; cl12078 243243006438 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243243006439 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243243006440 classical (c) SDRs; Region: SDR_c; cd05233 243243006441 NAD(P) binding site [chemical binding]; other site 243243006442 active site 243243006443 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 243243006444 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 243243006445 NAD binding site [chemical binding]; other site 243243006446 catalytic Zn binding site [ion binding]; other site 243243006447 substrate binding site [chemical binding]; other site 243243006448 structural Zn binding site [ion binding]; other site 243243006449 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243243006450 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243006451 NAD(P) binding site [chemical binding]; other site 243243006452 catalytic residues [active] 243243006453 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 243243006454 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243006455 active site 2 [active] 243243006456 active site 1 [active] 243243006457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006461 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006462 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006463 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006464 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006465 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 243243006466 active site 243243006467 metal binding site [ion binding]; metal-binding site 243243006468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006470 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243006471 Cytochrome P450; Region: p450; cl12078 243243006472 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243006473 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243006474 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 243243006475 putative FMN binding site [chemical binding]; other site 243243006476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006477 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243006478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006480 active site 243243006481 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006483 active site 243243006484 lipid-transfer protein; Provisional; Region: PRK07855 243243006485 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243006486 active site 243243006487 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243006488 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243006489 classical (c) SDRs; Region: SDR_c; cd05233 243243006490 NAD(P) binding site [chemical binding]; other site 243243006491 active site 243243006492 Ecdysteroid kinase; Region: EcKinase; cl17738 243243006493 Phosphotransferase enzyme family; Region: APH; pfam01636 243243006494 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243006495 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006496 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006497 active site 243243006498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006499 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243006500 MULE transposase domain; Region: MULE; pfam10551 243243006501 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 243243006502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006503 NAD(P) binding site [chemical binding]; other site 243243006504 active site 243243006505 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243006506 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006507 acyl-activating enzyme (AAE) consensus motif; other site 243243006508 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006509 AMP binding site [chemical binding]; other site 243243006510 active site 243243006511 acyl-activating enzyme (AAE) consensus motif; other site 243243006512 CoA binding site [chemical binding]; other site 243243006513 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243006514 SnoaL-like domain; Region: SnoaL_4; pfam13577 243243006515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 243243006516 Integrase core domain; Region: rve; pfam00665 243243006517 transposase; Provisional; Region: PRK06526 243243006518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243006519 Walker A motif; other site 243243006520 ATP binding site [chemical binding]; other site 243243006521 Walker B motif; other site 243243006522 putative transposase OrfB; Reviewed; Region: PHA02517 243243006523 HTH-like domain; Region: HTH_21; pfam13276 243243006524 Integrase core domain; Region: rve; pfam00665 243243006525 Integrase core domain; Region: rve_3; cl15866 243243006526 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243243006527 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243243006528 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 243243006529 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 243243006530 NifU-like domain; Region: NifU; cl00484 243243006531 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 243243006532 nickel binding site [ion binding]; other site 243243006533 Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with...; Region: Ribosomal_L10_P0; cl00376 243243006534 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 243243006535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243006536 motif II; other site 243243006537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 243243006538 Integrase core domain; Region: rve; pfam00665 243243006539 transposase; Provisional; Region: PRK06526 243243006540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243006541 Walker A motif; other site 243243006542 ATP binding site [chemical binding]; other site 243243006543 Walker B motif; other site 243243006544 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 243243006545 active site 243243006546 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 243243006547 catalytic triad [active] 243243006548 dimer interface [polypeptide binding]; other site 243243006549 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243006550 putative transposase OrfB; Reviewed; Region: PHA02517 243243006551 HTH-like domain; Region: HTH_21; pfam13276 243243006552 Integrase core domain; Region: rve; pfam00665 243243006553 Integrase core domain; Region: rve_3; cl15866 243243006554 Transposase; Region: HTH_Tnp_1; cl17663 243243006555 LGFP repeat; Region: LGFP; pfam08310 243243006556 short chain dehydrogenase; Provisional; Region: PRK07825 243243006557 classical (c) SDRs; Region: SDR_c; cd05233 243243006558 NAD(P) binding site [chemical binding]; other site 243243006559 active site 243243006560 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 243243006561 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006562 substrate binding site [chemical binding]; other site 243243006563 oxyanion hole (OAH) forming residues; other site 243243006564 trimer interface [polypeptide binding]; other site 243243006565 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243243006566 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243243006567 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 243243006568 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243006569 dimer interface [polypeptide binding]; other site 243243006570 active site 243243006571 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006572 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006573 active site 243243006574 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006575 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006578 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 243243006579 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 243243006580 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243006581 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 243243006582 short chain dehydrogenase; Provisional; Region: PRK07577 243243006583 classical (c) SDRs; Region: SDR_c; cd05233 243243006584 NAD(P) binding site [chemical binding]; other site 243243006585 active site 243243006586 Cellulose binding domain; Region: CBM_2; pfam00553 243243006587 Helix-turn-helix domain; Region: HTH_18; pfam12833 243243006588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 243243006589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243006590 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243006591 biotin carboxylase-like protein; Validated; Region: PRK06524 243243006592 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243243006593 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243243006594 Beta-lactamase; Region: Beta-lactamase; pfam00144 243243006595 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 243243006596 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 243243006597 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 243243006598 Ligand Binding Site [chemical binding]; other site 243243006599 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243243006600 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243243006601 putative dimer interface [polypeptide binding]; other site 243243006602 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 243243006603 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243006604 DNA binding residues [nucleotide binding] 243243006605 putative dimer interface [polypeptide binding]; other site 243243006606 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243243006607 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243243006608 putative dimer interface [polypeptide binding]; other site 243243006609 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243243006610 HSP70 interaction site [polypeptide binding]; other site 243243006611 Condensation domain; Region: Condensation; pfam00668 243243006612 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243243006613 short chain dehydrogenase; Provisional; Region: PRK06500 243243006614 classical (c) SDRs; Region: SDR_c; cd05233 243243006615 NAD(P) binding site [chemical binding]; other site 243243006616 active site 243243006617 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 243243006618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243006619 S-adenosylmethionine binding site [chemical binding]; other site 243243006620 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 243243006621 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 243243006622 putative oligomer interface [polypeptide binding]; other site 243243006623 putative active site [active] 243243006624 metal binding site [ion binding]; metal-binding site 243243006625 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 243243006626 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243006627 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243006628 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 243243006629 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 243243006630 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 243243006631 hypothetical protein; Provisional; Region: PRK06834 243243006632 hypothetical protein; Provisional; Region: PRK07236 243243006633 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243006634 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 243243006635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243006636 ATP binding site [chemical binding]; other site 243243006637 putative Mg++ binding site [ion binding]; other site 243243006638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243006639 nucleotide binding region [chemical binding]; other site 243243006640 ATP-binding site [chemical binding]; other site 243243006641 Helicase associated domain (HA2); Region: HA2; pfam04408 243243006642 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 243243006643 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 243243006644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243243006645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243243006646 metal binding site [ion binding]; metal-binding site 243243006647 active site 243243006648 I-site; other site 243243006649 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243006650 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006651 substrate binding site [chemical binding]; other site 243243006652 oxyanion hole (OAH) forming residues; other site 243243006653 trimer interface [polypeptide binding]; other site 243243006654 Cutinase; Region: Cutinase; pfam01083 243243006655 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 243243006656 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 243243006657 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 243243006658 MOSC domain; Region: MOSC; pfam03473 243243006659 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 243243006660 putative active site [active] 243243006661 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243006662 PPE family; Region: PPE; pfam00823 243243006663 Short C-terminal domain; Region: SHOCT; pfam09851 243243006664 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 243243006665 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243243006666 homodimer interface [polypeptide binding]; other site 243243006667 active site 243243006668 TDP-binding site; other site 243243006669 acceptor substrate-binding pocket; other site 243243006670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243006671 S-adenosylmethionine binding site [chemical binding]; other site 243243006672 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 243243006673 hydroxyglutarate oxidase; Provisional; Region: PRK11728 243243006674 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243243006675 iron-sulfur cluster [ion binding]; other site 243243006676 [2Fe-2S] cluster binding site [ion binding]; other site 243243006677 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 243243006678 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 243243006679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243243006680 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243243006681 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243243006682 metal binding site 2 [ion binding]; metal-binding site 243243006683 putative DNA binding helix; other site 243243006684 metal binding site 1 [ion binding]; metal-binding site 243243006685 dimer interface [polypeptide binding]; other site 243243006686 structural Zn2+ binding site [ion binding]; other site 243243006687 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 243243006688 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 243243006689 dimer interface [polypeptide binding]; other site 243243006690 active site 243243006691 heme binding site [chemical binding]; other site 243243006692 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 243243006693 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 243243006694 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243243006695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243006696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243006697 S-adenosylmethionine binding site [chemical binding]; other site 243243006698 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 243243006699 Protein of unknown function, DUF608; Region: DUF608; pfam04685 243243006700 Methyltransferase domain; Region: Methyltransf_24; pfam13578 243243006701 Cutinase; Region: Cutinase; pfam01083 243243006702 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 243243006703 active site 243243006704 catalytic residues [active] 243243006705 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243006706 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 243243006707 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243006708 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243243006709 NAD(P) binding site [chemical binding]; other site 243243006710 catalytic residues [active] 243243006711 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 243243006712 extended (e) SDRs; Region: SDR_e; cd08946 243243006713 NAD(P) binding site [chemical binding]; other site 243243006714 active site 243243006715 substrate binding site [chemical binding]; other site 243243006716 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006717 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006718 active site 243243006719 YacP-like NYN domain; Region: NYN_YacP; cl01491 243243006720 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 243243006721 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243006722 FMN binding site [chemical binding]; other site 243243006723 substrate binding site [chemical binding]; other site 243243006724 putative catalytic residue [active] 243243006725 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 243243006726 dimer interface [polypeptide binding]; other site 243243006727 catalytic triad [active] 243243006728 peroxidatic and resolving cysteines [active] 243243006729 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243243006730 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 243243006731 conserved cys residue [active] 243243006732 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243006733 short chain dehydrogenase; Provisional; Region: PRK05867 243243006734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006735 NAD(P) binding site [chemical binding]; other site 243243006736 active site 243243006737 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 243243006738 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243243006739 acyl-activating enzyme (AAE) consensus motif; other site 243243006740 active site 243243006741 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 243243006742 putative hydrophobic ligand binding site [chemical binding]; other site 243243006743 protein interface [polypeptide binding]; other site 243243006744 gate; other site 243243006745 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 243243006746 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 243243006747 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 243243006748 tetramer interface [polypeptide binding]; other site 243243006749 active site 243243006750 Mg2+/Mn2+ binding site [ion binding]; other site 243243006751 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 243243006752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243006753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243243006754 dimerization interface [polypeptide binding]; other site 243243006755 putative DNA binding site [nucleotide binding]; other site 243243006756 putative Zn2+ binding site [ion binding]; other site 243243006757 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 243243006758 putative hydrophobic ligand binding site [chemical binding]; other site 243243006759 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 243243006760 putative hydrophobic ligand binding site [chemical binding]; other site 243243006761 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243243006762 substrate binding site [chemical binding]; other site 243243006763 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 243243006764 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243006765 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243006766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243243006768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243006769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243243006770 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 243243006771 Nitronate monooxygenase; Region: NMO; pfam03060 243243006772 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243006773 FMN binding site [chemical binding]; other site 243243006774 substrate binding site [chemical binding]; other site 243243006775 putative catalytic residue [active] 243243006776 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 243243006777 hydrophobic ligand binding site; other site 243243006778 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 243243006779 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243006780 Predicted membrane protein [Function unknown]; Region: COG1950 243243006781 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243006782 putative sialic acid transporter; Region: 2A0112; TIGR00891 243243006783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243006784 putative substrate translocation pore; other site 243243006785 competence damage-inducible protein A; Provisional; Region: PRK00549 243243006786 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 243243006787 putative MPT binding site; other site 243243006788 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 243243006789 Domain of unknown function DUF77; Region: DUF77; cl00307 243243006790 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 243243006791 putative active site [active] 243243006792 dimerization interface [polypeptide binding]; other site 243243006793 putative tRNAtyr binding site [nucleotide binding]; other site 243243006794 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243006795 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243006796 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243243006797 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243243006798 NAD(P) binding site [chemical binding]; other site 243243006799 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243006800 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243006801 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243006802 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243006803 active site 243243006804 Nitronate monooxygenase; Region: NMO; pfam03060 243243006805 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243006806 FMN binding site [chemical binding]; other site 243243006807 substrate binding site [chemical binding]; other site 243243006808 putative catalytic residue [active] 243243006809 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243006810 Cytochrome P450; Region: p450; cl12078 243243006811 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243243006812 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 243243006813 putative NAD(P) binding site [chemical binding]; other site 243243006814 putative substrate binding site [chemical binding]; other site 243243006815 catalytic Zn binding site [ion binding]; other site 243243006816 structural Zn binding site [ion binding]; other site 243243006817 YceI-like domain; Region: YceI; smart00867 243243006818 Putative esterase; Region: Esterase; pfam00756 243243006819 chorismate mutase; Provisional; Region: PRK09269 243243006820 Chorismate mutase type II; Region: CM_2; cl00693 243243006821 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243243006822 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243243006823 catalytic residue [active] 243243006824 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 243243006825 hydrophobic ligand binding site; other site 243243006826 short chain dehydrogenase; Provisional; Region: PRK08267 243243006827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006828 NAD(P) binding site [chemical binding]; other site 243243006829 active site 243243006830 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 243243006831 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243006832 Cytochrome P450; Region: p450; cl12078 243243006833 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243006834 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243006835 MULE transposase domain; Region: MULE; pfam10551 243243006836 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243006837 MULE transposase domain; Region: MULE; pfam10551 243243006838 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243006839 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 243243006840 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243243006841 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 243243006842 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 243243006843 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243006844 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243006845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243006846 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243243006847 putative substrate translocation pore; other site 243243006848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243006849 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 243243006850 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 243243006851 heme binding site [chemical binding]; other site 243243006852 ferroxidase pore; other site 243243006853 ferroxidase diiron center [ion binding]; other site 243243006854 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 243243006855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243006856 substrate binding site [chemical binding]; other site 243243006857 oxyanion hole (OAH) forming residues; other site 243243006858 trimer interface [polypeptide binding]; other site 243243006859 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 243243006860 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 243243006861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243006862 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 243243006863 dimerization interface [polypeptide binding]; other site 243243006864 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243243006865 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 243243006866 dimer interface [polypeptide binding]; other site 243243006867 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243243006868 catalytic triad [active] 243243006869 peroxidatic and resolving cysteines [active] 243243006870 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 243243006871 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 243243006872 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 243243006873 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 243243006874 active site 243243006875 catalytic site [active] 243243006876 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 243243006877 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 243243006878 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 243243006879 active site 243243006880 substrate binding site [chemical binding]; other site 243243006881 FMN binding site [chemical binding]; other site 243243006882 putative catalytic residues [active] 243243006883 Domain of unknown function (DUF385); Region: DUF385; pfam04075 243243006884 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 243243006885 helix-hairpin-helix signature motif; other site 243243006886 Protein of unknown function DUF72; Region: DUF72; pfam01904 243243006887 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 243243006888 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243006889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243006890 hypothetical protein; Provisional; Region: PRK12320 243243006891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243006892 NAD(P) binding site [chemical binding]; other site 243243006893 active site 243243006894 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 243243006895 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243006896 active site 243243006897 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006898 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006899 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243006900 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243006901 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 243243006902 short chain dehydrogenase; Provisional; Region: PRK07825 243243006903 classical (c) SDRs; Region: SDR_c; cd05233 243243006904 NAD(P) binding site [chemical binding]; other site 243243006905 active site 243243006906 putative phosphoketolase; Provisional; Region: PRK05261 243243006907 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 243243006908 TPP-binding site; other site 243243006909 XFP C-terminal domain; Region: XFP_C; pfam09363 243243006910 CAAX protease self-immunity; Region: Abi; pfam02517 243243006911 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 243243006912 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 243243006913 putative NAD(P) binding site [chemical binding]; other site 243243006914 putative substrate binding site [chemical binding]; other site 243243006915 catalytic Zn binding site [ion binding]; other site 243243006916 structural Zn binding site [ion binding]; other site 243243006917 Predicted membrane protein [Function unknown]; Region: COG2261 243243006918 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 243243006919 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 243243006920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243006921 Walker A/P-loop; other site 243243006922 ATP binding site [chemical binding]; other site 243243006923 Q-loop/lid; other site 243243006924 ABC transporter signature motif; other site 243243006925 Walker B; other site 243243006926 D-loop; other site 243243006927 H-loop/switch region; other site 243243006928 TOBE domain; Region: TOBE; pfam03459 243243006929 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243243006930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243006931 putative PBP binding loops; other site 243243006932 ABC-ATPase subunit interface; other site 243243006933 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 243243006934 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 243243006935 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243243006936 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 243243006937 classical (c) SDRs; Region: SDR_c; cd05233 243243006938 NAD(P) binding site [chemical binding]; other site 243243006939 active site 243243006940 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 243243006941 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243006942 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243006943 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243243006944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243006945 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243006946 CoenzymeA binding site [chemical binding]; other site 243243006947 subunit interaction site [polypeptide binding]; other site 243243006948 PHB binding site; other site 243243006949 Predicted transcriptional regulator [Transcription]; Region: COG3682 243243006950 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 243243006951 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243243006952 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 243243006953 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 243243006954 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 243243006955 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243243006956 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 243243006957 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 243243006958 active site 243243006959 acyl carrier protein; Validated; Region: PRK05883 243243006960 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 243243006961 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243006962 acyl-activating enzyme (AAE) consensus motif; other site 243243006963 AMP binding site [chemical binding]; other site 243243006964 active site 243243006965 CoA binding site [chemical binding]; other site 243243006966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243006967 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243006968 active site 243243006969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 243243006970 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243243006971 Domain of unknown function DUF21; Region: DUF21; pfam01595 243243006972 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243243006973 Transporter associated domain; Region: CorC_HlyC; smart01091 243243006974 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243243006975 Domain of unknown function DUF21; Region: DUF21; pfam01595 243243006976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243243006977 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 243243006978 active site 243243006979 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243243006980 metal ion-dependent adhesion site (MIDAS); other site 243243006981 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 243243006982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243006983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243006984 glycine dehydrogenase; Provisional; Region: PRK05367 243243006985 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 243243006986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243006987 tetramer interface [polypeptide binding]; other site 243243006988 catalytic residue [active] 243243006989 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 243243006990 tetramer interface [polypeptide binding]; other site 243243006991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243006992 catalytic residue [active] 243243006993 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 243243006994 DNA binding residues [nucleotide binding] 243243006995 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243006996 putative dimer interface [polypeptide binding]; other site 243243006997 Bifunctional nuclease; Region: DNase-RNase; pfam02577 243243006998 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 243243006999 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243007000 DNA binding residues [nucleotide binding] 243243007001 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243007002 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243007003 phosphopeptide binding site; other site 243243007004 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243243007005 lipoyl attachment site [posttranslational modification]; other site 243243007006 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 243243007007 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 243243007008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 243243007009 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 243243007010 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 243243007011 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 243243007012 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 243243007013 hypothetical protein; Provisional; Region: PRK05858 243243007014 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243243007015 PYR/PP interface [polypeptide binding]; other site 243243007016 dimer interface [polypeptide binding]; other site 243243007017 TPP binding site [chemical binding]; other site 243243007018 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243243007019 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 243243007020 TPP-binding site; other site 243243007021 dimer interface [polypeptide binding]; other site 243243007022 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 243243007023 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 243243007024 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 243243007025 hypothetical protein; Validated; Region: PRK07121 243243007026 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 243243007027 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 243243007028 metal binding site [ion binding]; metal-binding site 243243007029 substrate binding site [chemical binding]; other site 243243007030 dimer interface [polypeptide binding]; other site 243243007031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243007032 Domain of unknown function (DUF385); Region: DUF385; cl04387 243243007033 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 243243007034 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 243243007035 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 243243007036 MgtC family; Region: MgtC; pfam02308 243243007037 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243007038 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007039 PPE family; Region: PPE; pfam00823 243243007040 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243007041 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007042 PPE family; Region: PPE; pfam00823 243243007043 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243007044 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243007045 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243007046 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007047 PPE family; Region: PPE; pfam00823 243243007048 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243007049 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007050 PPE family; Region: PPE; pfam00823 243243007051 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243007052 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243007053 MULE transposase domain; Region: MULE; pfam10551 243243007054 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243007055 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007056 PPE family; Region: PPE; pfam00823 243243007057 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243007058 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007059 PPE family; Region: PPE; pfam00823 243243007060 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243007061 PE family; Region: PE; pfam00934 243243007062 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 243243007063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 243243007064 TPR motif; other site 243243007065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243007066 Walker A motif; other site 243243007067 ATP binding site [chemical binding]; other site 243243007068 Walker B motif; other site 243243007069 arginine finger; other site 243243007070 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 243243007071 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243243007072 catalytic residues [active] 243243007073 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 243243007074 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 243243007075 active site 243243007076 catalytic residues [active] 243243007077 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 243243007078 EspG family; Region: ESX-1_EspG; pfam14011 243243007079 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 243243007080 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 243243007081 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007082 PPE family; Region: PPE; pfam00823 243243007083 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007084 PPE family; Region: PPE; pfam00823 243243007085 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007086 PPE family; Region: PPE; pfam00823 243243007087 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243007088 PPE family; Region: PPE; pfam00823 243243007089 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243243007090 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243007091 Cytochrome P450; Region: p450; cl12078 243243007092 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 243243007093 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243243007094 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 243243007095 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243243007096 Protein of unknown function (DUF690); Region: DUF690; pfam05108 243243007097 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 243243007098 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 243243007099 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243007100 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243007101 SnoaL-like domain; Region: SnoaL_4; pfam13577 243243007102 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 243243007103 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 243243007104 Moco binding site; other site 243243007105 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 243243007106 metal coordination site [ion binding]; other site 243243007107 hydrophobic ligand binding site; other site 243243007108 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 243243007109 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 243243007110 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 243243007111 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243007112 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243007113 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243007114 classical (c) SDRs; Region: SDR_c; cd05233 243243007115 NAD(P) binding site [chemical binding]; other site 243243007116 active site 243243007117 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 243243007118 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243243007119 tetramer interface [polypeptide binding]; other site 243243007120 TPP-binding site [chemical binding]; other site 243243007121 heterodimer interface [polypeptide binding]; other site 243243007122 phosphorylation loop region [posttranslational modification] 243243007123 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243243007124 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 243243007125 alpha subunit interface [polypeptide binding]; other site 243243007126 TPP binding site [chemical binding]; other site 243243007127 heterodimer interface [polypeptide binding]; other site 243243007128 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243243007129 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243243007130 E3 interaction surface; other site 243243007131 lipoyl attachment site [posttranslational modification]; other site 243243007132 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243007133 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243007134 substrate binding site [chemical binding]; other site 243243007135 oxyanion hole (OAH) forming residues; other site 243243007136 trimer interface [polypeptide binding]; other site 243243007137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243007138 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 243243007139 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243007140 acyl-activating enzyme (AAE) consensus motif; other site 243243007141 acyl-activating enzyme (AAE) consensus motif; other site 243243007142 putative AMP binding site [chemical binding]; other site 243243007143 putative active site [active] 243243007144 putative CoA binding site [chemical binding]; other site 243243007145 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243007146 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243007147 [2Fe-2S] cluster binding site [ion binding]; other site 243243007148 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 243243007149 putative alpha subunit interface [polypeptide binding]; other site 243243007150 putative active site [active] 243243007151 putative substrate binding site [chemical binding]; other site 243243007152 Fe binding site [ion binding]; other site 243243007153 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 243243007154 enoyl-CoA hydratase; Provisional; Region: PRK06190 243243007155 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243007156 substrate binding site [chemical binding]; other site 243243007157 oxyanion hole (OAH) forming residues; other site 243243007158 trimer interface [polypeptide binding]; other site 243243007159 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243243007160 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243243007161 ATP binding site [chemical binding]; other site 243243007162 Mg++ binding site [ion binding]; other site 243243007163 motif III; other site 243243007164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243007165 nucleotide binding region [chemical binding]; other site 243243007166 ATP-binding site [chemical binding]; other site 243243007167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243007168 S-adenosylmethionine binding site [chemical binding]; other site 243243007169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243007170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243007171 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 243243007172 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243007173 active site 243243007174 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243007175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243007176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243007177 Cutinase; Region: Cutinase; pfam01083 243243007178 classical (c) SDRs; Region: SDR_c; cd05233 243243007179 NAD(P) binding site [chemical binding]; other site 243243007180 active site 243243007181 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 243243007182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243007183 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243243007184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243007185 DNA binding residues [nucleotide binding] 243243007186 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 243243007187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243007188 Cytochrome P450; Region: p450; cl12078 243243007189 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243007190 short chain dehydrogenase; Provisional; Region: PRK05854 243243007191 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 243243007192 putative NAD(P) binding site [chemical binding]; other site 243243007193 active site 243243007194 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243243007195 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243243007196 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 243243007197 active site 243243007198 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243243007199 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243243007200 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 243243007201 active site 243243007202 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243007203 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243007204 MULE transposase domain; Region: MULE; pfam10551 243243007205 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243007206 MULE transposase domain; Region: MULE; pfam10551 243243007207 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243007208 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243007209 MULE transposase domain; Region: MULE; pfam10551 243243007210 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243007211 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243007212 active site 243243007213 Excalibur calcium-binding domain; Region: Excalibur; smart00894 243243007214 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 243243007215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243007216 NAD(P) binding site [chemical binding]; other site 243243007217 active site 243243007218 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243007219 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243007220 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243007221 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243007222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243007223 enoyl-CoA hydratase; Provisional; Region: PRK12478 243243007224 substrate binding site [chemical binding]; other site 243243007225 oxyanion hole (OAH) forming residues; other site 243243007226 trimer interface [polypeptide binding]; other site 243243007227 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243007228 classical (c) SDRs; Region: SDR_c; cd05233 243243007229 NAD(P) binding site [chemical binding]; other site 243243007230 active site 243243007231 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243007232 Cytochrome P450; Region: p450; cl12078 243243007233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 243243007234 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 243243007235 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243243007236 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243243007237 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243243007238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243007239 S-adenosylmethionine binding site [chemical binding]; other site 243243007240 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243243007241 Sulfatase; Region: Sulfatase; pfam00884 243243007242 Nitronate monooxygenase; Region: NMO; pfam03060 243243007243 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243007244 FMN binding site [chemical binding]; other site 243243007245 substrate binding site [chemical binding]; other site 243243007246 putative catalytic residue [active] 243243007247 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243007248 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 243243007249 MarR family; Region: MarR; pfam01047 243243007250 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243007251 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 243243007252 intersubunit interface [polypeptide binding]; other site 243243007253 active site 243243007254 Zn2+ binding site [ion binding]; other site 243243007255 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243007256 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 243243007257 acyl-activating enzyme (AAE) consensus motif; other site 243243007258 putative AMP binding site [chemical binding]; other site 243243007259 putative active site [active] 243243007260 putative CoA binding site [chemical binding]; other site 243243007261 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 243243007262 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 243243007263 Moco binding site; other site 243243007264 metal coordination site [ion binding]; other site 243243007265 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243007266 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243007267 active site 243243007268 acyl-CoA synthetase; Provisional; Region: PRK13388 243243007269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243007270 acyl-activating enzyme (AAE) consensus motif; other site 243243007271 AMP binding site [chemical binding]; other site 243243007272 active site 243243007273 CoA binding site [chemical binding]; other site 243243007274 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243007275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243007276 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243007277 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243007278 thiolase; Provisional; Region: PRK06158 243243007279 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243007280 active site 243243007281 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 243243007282 putative active site [active] 243243007283 putative catalytic site [active] 243243007284 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 243243007285 active site 243243007286 catalytic site [active] 243243007287 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243007288 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243007289 active site 243243007290 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243007291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243007292 active site 243243007293 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243007294 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243007295 phosphopeptide binding site; other site 243243007296 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243007297 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243007298 phosphopeptide binding site; other site 243243007299 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 243243007300 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243243007301 Walker A/P-loop; other site 243243007302 ATP binding site [chemical binding]; other site 243243007303 Q-loop/lid; other site 243243007304 ABC transporter signature motif; other site 243243007305 Walker B; other site 243243007306 D-loop; other site 243243007307 H-loop/switch region; other site 243243007308 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243243007309 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243243007310 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243007311 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243007312 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 243243007313 classical (c) SDRs; Region: SDR_c; cd05233 243243007314 NAD(P) binding site [chemical binding]; other site 243243007315 active site 243243007316 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 243243007317 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243007318 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243007319 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243007320 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 243243007321 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243007322 classical (c) SDRs; Region: SDR_c; cd05233 243243007323 NAD(P) binding site [chemical binding]; other site 243243007324 active site 243243007325 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243007326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243007327 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 243243007328 classical (c) SDRs; Region: SDR_c; cd05233 243243007329 NAD(P) binding site [chemical binding]; other site 243243007330 active site 243243007331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243007332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243007333 active site 243243007334 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 243243007335 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 243243007336 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 243243007337 active site 243243007338 Fe binding site [ion binding]; other site 243243007339 hypothetical protein; Validated; Region: PRK07121 243243007340 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243243007341 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243243007342 Bacterial transcriptional regulator; Region: IclR; pfam01614 243243007343 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243007344 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243007345 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 243243007346 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 243243007347 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 243243007348 NAD(P) binding site [chemical binding]; other site 243243007349 homodimer interface [polypeptide binding]; other site 243243007350 active site 243243007351 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243007352 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243007353 SnoaL-like domain; Region: SnoaL_4; pfam13577 243243007354 hypothetical protein; Provisional; Region: PRK06194 243243007355 classical (c) SDRs; Region: SDR_c; cd05233 243243007356 NAD(P) binding site [chemical binding]; other site 243243007357 active site 243243007358 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243007359 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 243243007360 classical (c) SDRs; Region: SDR_c; cd05233 243243007361 NAD(P) binding site [chemical binding]; other site 243243007362 active site 243243007363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243007364 short chain dehydrogenase; Provisional; Region: PRK08303 243243007365 NAD(P) binding site [chemical binding]; other site 243243007366 active site 243243007367 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243007368 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 243243007369 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243007370 MULE transposase domain; Region: MULE; pfam10551 243243007371 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 243243007372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243007373 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 243243007374 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243007375 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243007376 active site 243243007377 Predicted transcriptional regulators [Transcription]; Region: COG1695 243243007378 Transcriptional regulator PadR-like family; Region: PadR; cl17335 243243007379 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243007380 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243007381 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243243007382 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 243243007383 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 243243007384 Multicopper oxidase; Region: Cu-oxidase; pfam00394 243243007385 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 243243007386 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 243243007387 hypothetical protein; Provisional; Region: PRK14059 243243007388 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 243243007389 benzoate transport; Region: 2A0115; TIGR00895 243243007390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243007391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243007392 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 243243007393 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243243007394 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243243007395 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 243243007396 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243243007397 dimer interface [polypeptide binding]; other site 243243007398 active site 243243007399 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243243007400 Ligand Binding Site [chemical binding]; other site 243243007401 Molecular Tunnel; other site 243243007402 Condensation domain; Region: Condensation; pfam00668 243243007403 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243007404 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243243007405 acyl-activating enzyme (AAE) consensus motif; other site 243243007406 AMP binding site [chemical binding]; other site 243243007407 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243007408 Condensation domain; Region: Condensation; pfam00668 243243007409 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 243243007410 Condensation domain; Region: Condensation; pfam00668 243243007411 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243007412 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243007413 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243243007414 acyl-activating enzyme (AAE) consensus motif; other site 243243007415 AMP binding site [chemical binding]; other site 243243007416 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243243007417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243007418 S-adenosylmethionine binding site [chemical binding]; other site 243243007419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243007420 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243007421 Condensation domain; Region: Condensation; pfam00668 243243007422 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243007423 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243007424 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243007425 acyl-activating enzyme (AAE) consensus motif; other site 243243007426 AMP binding site [chemical binding]; other site 243243007427 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243007428 Condensation domain; Region: Condensation; pfam00668 243243007429 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243007430 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243007431 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243007432 acyl-activating enzyme (AAE) consensus motif; other site 243243007433 AMP binding site [chemical binding]; other site 243243007434 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243007435 peptide synthase; Provisional; Region: PRK12316 243243007436 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243007437 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243007438 acyl-activating enzyme (AAE) consensus motif; other site 243243007439 AMP binding site [chemical binding]; other site 243243007440 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243007441 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 243243007442 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243007443 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243007444 acyl-activating enzyme (AAE) consensus motif; other site 243243007445 AMP binding site [chemical binding]; other site 243243007446 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243007447 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243007448 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243007449 acyl-activating enzyme (AAE) consensus motif; other site 243243007450 AMP binding site [chemical binding]; other site 243243007451 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243007452 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 243243007453 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243007454 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243007455 acyl-activating enzyme (AAE) consensus motif; other site 243243007456 AMP binding site [chemical binding]; other site 243243007457 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243007458 Thioesterase domain; Region: Thioesterase; pfam00975 243243007459 MbtH-like protein; Region: MbtH; pfam03621 243243007460 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 243243007461 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 243243007462 GTP-binding protein Der; Reviewed; Region: PRK03003 243243007463 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 243243007464 G1 box; other site 243243007465 GTP/Mg2+ binding site [chemical binding]; other site 243243007466 Switch I region; other site 243243007467 G2 box; other site 243243007468 Switch II region; other site 243243007469 G3 box; other site 243243007470 G4 box; other site 243243007471 G5 box; other site 243243007472 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 243243007473 G1 box; other site 243243007474 GTP/Mg2+ binding site [chemical binding]; other site 243243007475 Switch I region; other site 243243007476 G2 box; other site 243243007477 G3 box; other site 243243007478 Switch II region; other site 243243007479 G4 box; other site 243243007480 G5 box; other site 243243007481 cytidylate kinase; Provisional; Region: cmk; PRK00023 243243007482 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 243243007483 CMP-binding site; other site 243243007484 The sites determining sugar specificity; other site 243243007485 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 243243007486 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243243007487 RNA binding surface [nucleotide binding]; other site 243243007488 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 243243007489 active site 243243007490 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 243243007491 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 243243007492 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243243007493 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243243007494 P-loop; other site 243243007495 Magnesium ion binding site [ion binding]; other site 243243007496 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243243007497 Magnesium ion binding site [ion binding]; other site 243243007498 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 243243007499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243243007500 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 243243007501 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243007502 active site 243243007503 DNA binding site [nucleotide binding] 243243007504 Int/Topo IB signature motif; other site 243243007505 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 243243007506 dimer interface [polypeptide binding]; other site 243243007507 ADP-ribose binding site [chemical binding]; other site 243243007508 active site 243243007509 nudix motif; other site 243243007510 metal binding site [ion binding]; metal-binding site 243243007511 CTP synthetase; Validated; Region: pyrG; PRK05380 243243007512 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 243243007513 Catalytic site [active] 243243007514 active site 243243007515 UTP binding site [chemical binding]; other site 243243007516 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 243243007517 active site 243243007518 putative oxyanion hole; other site 243243007519 catalytic triad [active] 243243007520 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 243243007521 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 243243007522 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 243243007523 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 243243007524 DNA repair protein RecN; Region: recN; TIGR00634 243243007525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243007526 Walker A/P-loop; other site 243243007527 ATP binding site [chemical binding]; other site 243243007528 Q-loop/lid; other site 243243007529 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243243007530 ABC transporter signature motif; other site 243243007531 Walker B; other site 243243007532 D-loop; other site 243243007533 H-loop/switch region; other site 243243007534 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 243243007535 ATP-NAD kinase; Region: NAD_kinase; pfam01513 243243007536 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 243243007537 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243243007538 RNA binding surface [nucleotide binding]; other site 243243007539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243007540 S-adenosylmethionine binding site [chemical binding]; other site 243243007541 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 243243007542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243007543 active site 243243007544 motif I; other site 243243007545 motif II; other site 243243007546 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 243243007547 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243007548 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 243243007549 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 243243007550 active site 243243007551 HIGH motif; other site 243243007552 dimer interface [polypeptide binding]; other site 243243007553 KMSKS motif; other site 243243007554 S4 RNA-binding domain; Region: S4; smart00363 243243007555 RNA binding surface [nucleotide binding]; other site 243243007556 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 243243007557 active site 243243007558 DNA binding site [nucleotide binding] 243243007559 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243243007560 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 243243007561 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243243007562 Walker A/P-loop; other site 243243007563 ATP binding site [chemical binding]; other site 243243007564 Q-loop/lid; other site 243243007565 ABC transporter signature motif; other site 243243007566 Walker B; other site 243243007567 D-loop; other site 243243007568 H-loop/switch region; other site 243243007569 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 243243007570 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243243007571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243007572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243007573 Uncharacterized conserved protein [Function unknown]; Region: COG2835 243243007574 acyl-CoA synthetase; Validated; Region: PRK07868 243243007575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243007576 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243007577 active site 243243007578 CoA binding site [chemical binding]; other site 243243007579 AMP binding site [chemical binding]; other site 243243007580 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 243243007581 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 243243007582 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243243007583 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 243243007584 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 243243007585 short chain dehydrogenase; Provisional; Region: PRK07109 243243007586 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 243243007587 putative NAD(P) binding site [chemical binding]; other site 243243007588 active site 243243007589 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 243243007590 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 243243007591 putative active site pocket [active] 243243007592 putative metal binding site [ion binding]; other site 243243007593 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243007594 classical (c) SDRs; Region: SDR_c; cd05233 243243007595 NAD(P) binding site [chemical binding]; other site 243243007596 active site 243243007597 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243007598 classical (c) SDRs; Region: SDR_c; cd05233 243243007599 NAD(P) binding site [chemical binding]; other site 243243007600 active site 243243007601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243243007602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243007603 NAD(P) binding site [chemical binding]; other site 243243007604 active site 243243007605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243243007606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243007607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243243007608 dimerization interface [polypeptide binding]; other site 243243007609 PAS fold; Region: PAS_3; pfam08447 243243007610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243243007611 putative active site [active] 243243007612 heme pocket [chemical binding]; other site 243243007613 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 243243007614 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 243243007615 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243243007616 ABC transporter; Region: ABC_tran_2; pfam12848 243243007617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243007618 Walker A/P-loop; other site 243243007619 ATP binding site [chemical binding]; other site 243243007620 Q-loop/lid; other site 243243007621 ABC transporter signature motif; other site 243243007622 Walker B; other site 243243007623 D-loop; other site 243243007624 H-loop/switch region; other site 243243007625 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243007626 Cytochrome P450; Region: p450; cl12078 243243007627 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 243243007628 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 243243007629 malonyl-CoA binding site [chemical binding]; other site 243243007630 dimer interface [polypeptide binding]; other site 243243007631 active site 243243007632 product binding site; other site 243243007633 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243007634 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 243243007635 active site 243243007636 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243243007637 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243007638 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243007639 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243243007640 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243007641 active site 243243007642 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243007643 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243243007644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243007645 Enoylreductase; Region: PKS_ER; smart00829 243243007646 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243243007647 NAD(P) binding site [chemical binding]; other site 243243007648 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 243243007649 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243243007650 putative NADP binding site [chemical binding]; other site 243243007651 active site 243243007652 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243007653 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 243243007654 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243243007655 active site 243243007656 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 243243007657 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243243007658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243007659 Enoylreductase; Region: PKS_ER; smart00829 243243007660 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 243243007661 NAD(P) binding site [chemical binding]; other site 243243007662 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 243243007663 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243243007664 putative NADP binding site [chemical binding]; other site 243243007665 active site 243243007666 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243007667 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 243243007668 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 243243007669 malonyl-CoA binding site [chemical binding]; other site 243243007670 dimer interface [polypeptide binding]; other site 243243007671 active site 243243007672 product binding site; other site 243243007673 argininosuccinate lyase; Provisional; Region: PRK00855 243243007674 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 243243007675 active sites [active] 243243007676 tetramer interface [polypeptide binding]; other site 243243007677 argininosuccinate synthase; Provisional; Region: PRK13820 243243007678 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 243243007679 ANP binding site [chemical binding]; other site 243243007680 Substrate Binding Site II [chemical binding]; other site 243243007681 Substrate Binding Site I [chemical binding]; other site 243243007682 arginine repressor; Provisional; Region: PRK03341 243243007683 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 243243007684 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 243243007685 ornithine carbamoyltransferase; Provisional; Region: PRK00779 243243007686 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243243007687 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243243007688 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 243243007689 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243243007690 inhibitor-cofactor binding pocket; inhibition site 243243007691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243007692 catalytic residue [active] 243243007693 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 243243007694 feedback inhibition sensing region; other site 243243007695 homohexameric interface [polypeptide binding]; other site 243243007696 nucleotide binding site [chemical binding]; other site 243243007697 N-acetyl-L-glutamate binding site [chemical binding]; other site 243243007698 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 243243007699 heterotetramer interface [polypeptide binding]; other site 243243007700 active site pocket [active] 243243007701 cleavage site 243243007702 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 243243007703 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243243007704 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 243243007705 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 243243007706 putative tRNA-binding site [nucleotide binding]; other site 243243007707 B3/4 domain; Region: B3_4; pfam03483 243243007708 tRNA synthetase B5 domain; Region: B5; smart00874 243243007709 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 243243007710 dimer interface [polypeptide binding]; other site 243243007711 motif 1; other site 243243007712 motif 3; other site 243243007713 motif 2; other site 243243007714 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 243243007715 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 243243007716 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 243243007717 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 243243007718 dimer interface [polypeptide binding]; other site 243243007719 motif 1; other site 243243007720 active site 243243007721 motif 2; other site 243243007722 motif 3; other site 243243007723 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243243007724 cyclase homology domain; Region: CHD; cd07302 243243007725 nucleotidyl binding site; other site 243243007726 metal binding site [ion binding]; metal-binding site 243243007727 dimer interface [polypeptide binding]; other site 243243007728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 243243007729 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 243243007730 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 243243007731 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243243007732 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 243243007733 23S rRNA binding site [nucleotide binding]; other site 243243007734 L21 binding site [polypeptide binding]; other site 243243007735 L13 binding site [polypeptide binding]; other site 243243007736 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 243243007737 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 243243007738 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 243243007739 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 243243007740 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 243243007741 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 243243007742 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 243243007743 dimer interface [polypeptide binding]; other site 243243007744 putative anticodon binding site; other site 243243007745 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243243007746 motif 1; other site 243243007747 dimer interface [polypeptide binding]; other site 243243007748 active site 243243007749 motif 2; other site 243243007750 motif 3; other site 243243007751 Predicted esterase [General function prediction only]; Region: COG0627 243243007752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243007753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243007754 hypothetical protein; Provisional; Region: PRK07877 243243007755 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 243243007756 ATP binding site [chemical binding]; other site 243243007757 substrate interface [chemical binding]; other site 243243007758 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 243243007759 GAF domain; Region: GAF; cl17456 243243007760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243243007761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243243007762 metal binding site [ion binding]; metal-binding site 243243007763 active site 243243007764 I-site; other site 243243007765 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243243007766 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 243243007767 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243243007768 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243243007769 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243243007770 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243243007771 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 243243007772 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243243007773 Ligand Binding Site [chemical binding]; other site 243243007774 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243243007775 MgtC family; Region: MgtC; pfam02308 243243007776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243007777 putative substrate translocation pore; other site 243243007778 excinuclease ABC subunit B; Provisional; Region: PRK05298 243243007779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243007780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243007781 nucleotide binding region [chemical binding]; other site 243243007782 ATP-binding site [chemical binding]; other site 243243007783 Ultra-violet resistance protein B; Region: UvrB; pfam12344 243243007784 UvrB/uvrC motif; Region: UVR; pfam02151 243243007785 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243007786 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 243243007787 active site 243243007788 ATP binding site [chemical binding]; other site 243243007789 substrate binding site [chemical binding]; other site 243243007790 activation loop (A-loop); other site 243243007791 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243007792 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243007793 phosphopeptide binding site; other site 243243007794 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243007795 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243007796 phosphopeptide binding site; other site 243243007797 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243243007798 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 243243007799 Walker A/P-loop; other site 243243007800 ATP binding site [chemical binding]; other site 243243007801 Q-loop/lid; other site 243243007802 ABC transporter signature motif; other site 243243007803 Walker B; other site 243243007804 D-loop; other site 243243007805 H-loop/switch region; other site 243243007806 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243243007807 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 243243007808 Protein of unknown function (DUF402); Region: DUF402; cl00979 243243007809 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 243243007810 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 243243007811 active site 243243007812 DNA binding site [nucleotide binding] 243243007813 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 243243007814 DNA binding site [nucleotide binding] 243243007815 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 243243007816 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 243243007817 DNA binding site [nucleotide binding] 243243007818 catalytic residue [active] 243243007819 H2TH interface [polypeptide binding]; other site 243243007820 putative catalytic residues [active] 243243007821 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243243007822 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243243007823 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 243243007824 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 243243007825 CoA-binding site [chemical binding]; other site 243243007826 ATP-binding [chemical binding]; other site 243243007827 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 243243007828 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 243243007829 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 243243007830 RNA binding site [nucleotide binding]; other site 243243007831 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 243243007832 RNA binding site [nucleotide binding]; other site 243243007833 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243243007834 RNA binding site [nucleotide binding]; other site 243243007835 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 243243007836 RNA binding site [nucleotide binding]; other site 243243007837 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 243243007838 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 243243007839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243007840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243007841 5'-3' exonuclease; Region: 53EXOc; smart00475 243243007842 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 243243007843 active site 243243007844 metal binding site 1 [ion binding]; metal-binding site 243243007845 putative 5' ssDNA interaction site; other site 243243007846 metal binding site 3; metal-binding site 243243007847 metal binding site 2 [ion binding]; metal-binding site 243243007848 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 243243007849 putative DNA binding site [nucleotide binding]; other site 243243007850 putative metal binding site [ion binding]; other site 243243007851 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 243243007852 DNA polymerase I; Provisional; Region: PRK05755 243243007853 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 243243007854 active site 243243007855 DNA binding site [nucleotide binding] 243243007856 catalytic site [active] 243243007857 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 243243007858 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243007859 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243007860 lipid-transfer protein; Provisional; Region: PRK06059 243243007861 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243007862 active site 243243007863 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 243243007864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243007865 active site 243243007866 phosphorylation site [posttranslational modification] 243243007867 intermolecular recognition site; other site 243243007868 dimerization interface [polypeptide binding]; other site 243243007869 ANTAR domain; Region: ANTAR; pfam03861 243243007870 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243007871 MULE transposase domain; Region: MULE; pfam10551 243243007872 Heme NO binding associated; Region: HNOBA; pfam07701 243243007873 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 243243007874 cyclase homology domain; Region: CHD; cd07302 243243007875 nucleotidyl binding site; other site 243243007876 metal binding site [ion binding]; metal-binding site 243243007877 dimer interface [polypeptide binding]; other site 243243007878 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 243243007879 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 243243007880 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 243243007881 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 243243007882 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 243243007883 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 243243007884 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 243243007885 Walker A/P-loop; other site 243243007886 ATP binding site [chemical binding]; other site 243243007887 Q-loop/lid; other site 243243007888 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 243243007889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243007890 Walker A/P-loop; other site 243243007891 ATP binding site [chemical binding]; other site 243243007892 Q-loop/lid; other site 243243007893 ABC transporter signature motif; other site 243243007894 Walker B; other site 243243007895 D-loop; other site 243243007896 H-loop/switch region; other site 243243007897 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 243243007898 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 243243007899 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 243243007900 active site 243243007901 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 243243007902 catalytic triad [active] 243243007903 dimer interface [polypeptide binding]; other site 243243007904 pyruvate kinase; Provisional; Region: PRK06247 243243007905 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 243243007906 active site 243243007907 domain interfaces; other site 243243007908 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 243243007909 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 243243007910 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 243243007911 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 243243007912 substrate binding site [chemical binding]; other site 243243007913 active site 243243007914 catalytic residues [active] 243243007915 heterodimer interface [polypeptide binding]; other site 243243007916 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 243243007917 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 243243007918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243007919 catalytic residue [active] 243243007920 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 243243007921 active site 243243007922 ribulose/triose binding site [chemical binding]; other site 243243007923 phosphate binding site [ion binding]; other site 243243007924 substrate (anthranilate) binding pocket [chemical binding]; other site 243243007925 product (indole) binding pocket [chemical binding]; other site 243243007926 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 243243007927 anthranilate synthase component I; Provisional; Region: PRK13571 243243007928 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243243007929 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243243007930 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243243007931 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 243243007932 catalytic triad [active] 243243007933 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 243243007934 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243243007935 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 243243007936 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 243243007937 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 243243007938 substrate binding site [chemical binding]; other site 243243007939 glutamase interaction surface [polypeptide binding]; other site 243243007940 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243243007941 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 243243007942 active site 243243007943 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 243243007944 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 243243007945 catalytic residues [active] 243243007946 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 243243007947 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 243243007948 putative active site [active] 243243007949 oxyanion strand; other site 243243007950 catalytic triad [active] 243243007951 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 243243007952 putative active site pocket [active] 243243007953 4-fold oligomerization interface [polypeptide binding]; other site 243243007954 metal binding residues [ion binding]; metal-binding site 243243007955 3-fold/trimer interface [polypeptide binding]; other site 243243007956 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 243243007957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243007958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243007959 homodimer interface [polypeptide binding]; other site 243243007960 catalytic residue [active] 243243007961 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 243243007962 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 243243007963 NAD binding site [chemical binding]; other site 243243007964 dimerization interface [polypeptide binding]; other site 243243007965 product binding site; other site 243243007966 substrate binding site [chemical binding]; other site 243243007967 zinc binding site [ion binding]; other site 243243007968 catalytic residues [active] 243243007969 Domain of unknown function (DUF385); Region: DUF385; cl04387 243243007970 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 243243007971 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 243243007972 dimerization interface [polypeptide binding]; other site 243243007973 active site 243243007974 L-aspartate oxidase; Provisional; Region: PRK07804 243243007975 L-aspartate oxidase; Provisional; Region: PRK06175 243243007976 quinolinate synthetase; Provisional; Region: PRK09375 243243007977 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 243243007978 nudix motif; other site 243243007979 Secretory lipase; Region: LIP; pfam03583 243243007980 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 243243007981 biotin synthase; Validated; Region: PRK06256 243243007982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243243007983 FeS/SAM binding site; other site 243243007984 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 243243007985 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243243007986 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243243007987 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243243007988 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243243007989 ligand binding site [chemical binding]; other site 243243007990 flexible hinge region; other site 243243007991 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 243243007992 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 243243007993 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 243243007994 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 243243007995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243007996 catalytic residue [active] 243243007997 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 243243007998 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243243007999 inhibitor-cofactor binding pocket; inhibition site 243243008000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243008001 catalytic residue [active] 243243008002 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243243008003 NlpC/P60 family; Region: NLPC_P60; pfam00877 243243008004 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243008005 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 243243008006 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 243243008007 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 243243008008 active site 243243008009 catalytic site [active] 243243008010 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 243243008011 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 243243008012 active site 243243008013 catalytic site [active] 243243008014 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 243243008015 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 243243008016 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 243243008017 catalytic site [active] 243243008018 active site 243243008019 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 243243008020 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 243243008021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243008022 DNA-binding site [nucleotide binding]; DNA binding site 243243008023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243008024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243008025 homodimer interface [polypeptide binding]; other site 243243008026 catalytic residue [active] 243243008027 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 243243008028 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 243243008029 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243243008030 active site 243243008031 threonine dehydratase; Validated; Region: PRK08639 243243008032 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 243243008033 tetramer interface [polypeptide binding]; other site 243243008034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243008035 catalytic residue [active] 243243008036 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 243243008037 putative Ile/Val binding site [chemical binding]; other site 243243008038 Domain of unknown function (DUF385); Region: DUF385; pfam04075 243243008039 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 243243008040 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 243243008041 putative acyl-acceptor binding pocket; other site 243243008042 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 243243008043 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 243243008044 acyl-activating enzyme (AAE) consensus motif; other site 243243008045 putative AMP binding site [chemical binding]; other site 243243008046 putative active site [active] 243243008047 putative CoA binding site [chemical binding]; other site 243243008048 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 243243008049 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243008050 DNA binding residues [nucleotide binding] 243243008051 putative dimer interface [polypeptide binding]; other site 243243008052 putative metal binding residues [ion binding]; other site 243243008053 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 243243008054 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 243243008055 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 243243008056 active site 243243008057 PHP Thumb interface [polypeptide binding]; other site 243243008058 metal binding site [ion binding]; metal-binding site 243243008059 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243243008060 generic binding surface II; other site 243243008061 generic binding surface I; other site 243243008062 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 243243008063 hydrophobic ligand binding site; other site 243243008064 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243243008065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243008066 NAD(P) binding site [chemical binding]; other site 243243008067 active site 243243008068 short chain dehydrogenase; Provisional; Region: PRK05866 243243008069 classical (c) SDRs; Region: SDR_c; cd05233 243243008070 NAD(P) binding site [chemical binding]; other site 243243008071 active site 243243008072 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 243243008073 apolar tunnel; other site 243243008074 heme binding site [chemical binding]; other site 243243008075 dimerization interface [polypeptide binding]; other site 243243008076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243008077 S-adenosylmethionine binding site [chemical binding]; other site 243243008078 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 243243008079 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243243008080 active site 243243008081 lipoprotein signal peptidase; Provisional; Region: PRK14764 243243008082 lipoprotein signal peptidase; Provisional; Region: PRK14787 243243008083 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 243243008084 active site 243243008085 homodimer interface [polypeptide binding]; other site 243243008086 homotetramer interface [polypeptide binding]; other site 243243008087 DNA polymerase IV; Provisional; Region: PRK03348 243243008088 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243243008089 active site 243243008090 DNA binding site [nucleotide binding] 243243008091 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 243243008092 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 243243008093 putative active site [active] 243243008094 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 243243008095 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 243243008096 HIGH motif; other site 243243008097 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 243243008098 active site 243243008099 KMSKS motif; other site 243243008100 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 243243008101 tRNA binding surface [nucleotide binding]; other site 243243008102 anticodon binding site; other site 243243008103 Nitronate monooxygenase; Region: NMO; pfam03060 243243008104 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243008105 FMN binding site [chemical binding]; other site 243243008106 substrate binding site [chemical binding]; other site 243243008107 putative catalytic residue [active] 243243008108 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243008109 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243008110 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008111 peptide synthase; Provisional; Region: PRK12467 243243008112 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243008113 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008114 acyl-activating enzyme (AAE) consensus motif; other site 243243008115 AMP binding site [chemical binding]; other site 243243008116 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008117 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243008118 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008119 acyl-activating enzyme (AAE) consensus motif; other site 243243008120 AMP binding site [chemical binding]; other site 243243008121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008122 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 243243008123 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008124 acyl-activating enzyme (AAE) consensus motif; other site 243243008125 AMP binding site [chemical binding]; other site 243243008126 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008127 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243008128 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243008129 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008130 acyl-activating enzyme (AAE) consensus motif; other site 243243008131 AMP binding site [chemical binding]; other site 243243008132 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008133 Condensation domain; Region: Condensation; pfam00668 243243008134 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243008135 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243008136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008137 acyl-activating enzyme (AAE) consensus motif; other site 243243008138 AMP binding site [chemical binding]; other site 243243008139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008140 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 243243008141 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 243243008142 putative NAD(P) binding site [chemical binding]; other site 243243008143 active site 243243008144 putative substrate binding site [chemical binding]; other site 243243008145 putative transposase OrfB; Reviewed; Region: PHA02517 243243008146 HTH-like domain; Region: HTH_21; pfam13276 243243008147 Integrase core domain; Region: rve; pfam00665 243243008148 Integrase core domain; Region: rve_3; cl15866 243243008149 Condensation domain; Region: Condensation; pfam00668 243243008150 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008151 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243243008152 acyl-activating enzyme (AAE) consensus motif; other site 243243008153 AMP binding site [chemical binding]; other site 243243008154 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008155 Condensation domain; Region: Condensation; pfam00668 243243008156 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008157 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243243008158 acyl-activating enzyme (AAE) consensus motif; other site 243243008159 AMP binding site [chemical binding]; other site 243243008160 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008161 Condensation domain; Region: Condensation; pfam00668 243243008162 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 243243008163 Condensation domain; Region: Condensation; pfam00668 243243008164 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243008165 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243008166 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008167 acyl-activating enzyme (AAE) consensus motif; other site 243243008168 AMP binding site [chemical binding]; other site 243243008169 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008170 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 243243008171 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 243243008172 putative NAD(P) binding site [chemical binding]; other site 243243008173 active site 243243008174 putative substrate binding site [chemical binding]; other site 243243008175 Condensation domain; Region: Condensation; pfam00668 243243008176 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008177 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243243008178 acyl-activating enzyme (AAE) consensus motif; other site 243243008179 AMP binding site [chemical binding]; other site 243243008180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008181 Condensation domain; Region: Condensation; pfam00668 243243008182 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 243243008183 Condensation domain; Region: Condensation; pfam00668 243243008184 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243008185 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243243008186 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243243008187 acyl-activating enzyme (AAE) consensus motif; other site 243243008188 AMP binding site [chemical binding]; other site 243243008189 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243243008190 Condensation domain; Region: Condensation; pfam00668 243243008191 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 243243008192 Condensation domain; Region: Condensation; pfam00668 243243008193 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 243243008194 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 243243008195 MbtH-like protein; Region: MbtH; pfam03621 243243008196 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243008197 MULE transposase domain; Region: MULE; pfam10551 243243008198 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243008199 Transport protein; Region: actII; TIGR00833 243243008200 Transport protein; Region: actII; TIGR00833 243243008201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243008202 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 243243008203 Walker A/P-loop; other site 243243008204 ATP binding site [chemical binding]; other site 243243008205 Q-loop/lid; other site 243243008206 ABC transporter signature motif; other site 243243008207 Walker B; other site 243243008208 D-loop; other site 243243008209 H-loop/switch region; other site 243243008210 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243243008211 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243243008212 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 243243008213 daunorubicin resistance protein C; Region: drrC; TIGR01248 243243008214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243243008215 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243008216 MULE transposase domain; Region: MULE; pfam10551 243243008217 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243243008218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243243008219 active site 243243008220 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 243243008221 Methyltransferase domain; Region: Methyltransf_24; pfam13578 243243008222 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 243243008223 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243243008224 homodimer interface [polypeptide binding]; other site 243243008225 active site 243243008226 TDP-binding site; other site 243243008227 acceptor substrate-binding pocket; other site 243243008228 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243243008229 classical (c) SDRs; Region: SDR_c; cd05233 243243008230 NAD(P) binding site [chemical binding]; other site 243243008231 active site 243243008232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243243008233 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 243243008234 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 243243008235 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243243008236 homodimer interface [polypeptide binding]; other site 243243008237 active site 243243008238 TDP-binding site; other site 243243008239 Transposase; Region: HTH_Tnp_1; cl17663 243243008240 putative transposase OrfB; Reviewed; Region: PHA02517 243243008241 HTH-like domain; Region: HTH_21; pfam13276 243243008242 Integrase core domain; Region: rve; pfam00665 243243008243 Integrase core domain; Region: rve_3; cl15866 243243008244 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 243243008245 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243243008246 homodimer interface [polypeptide binding]; other site 243243008247 active site 243243008248 TDP-binding site; other site 243243008249 acceptor substrate-binding pocket; other site 243243008250 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 243243008251 Methyltransferase domain; Region: Methyltransf_24; pfam13578 243243008252 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243008253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243008254 NAD(P) binding site [chemical binding]; other site 243243008255 active site 243243008256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 243243008257 putative transposase OrfB; Reviewed; Region: PHA02517 243243008258 HTH-like domain; Region: HTH_21; pfam13276 243243008259 Integrase core domain; Region: rve; pfam00665 243243008260 Integrase core domain; Region: rve_3; cl15866 243243008261 Transposase; Region: HTH_Tnp_1; cl17663 243243008262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 243243008263 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243008264 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243243008265 Beta-lactamase; Region: Beta-lactamase; pfam00144 243243008266 membrane ATPase/protein kinase; Provisional; Region: PRK09435 243243008267 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 243243008268 Walker A; other site 243243008269 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 243243008270 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 243243008271 active site 243243008272 substrate binding site [chemical binding]; other site 243243008273 coenzyme B12 binding site [chemical binding]; other site 243243008274 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 243243008275 B12 binding site [chemical binding]; other site 243243008276 cobalt ligand [ion binding]; other site 243243008277 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 243243008278 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 243243008279 heterodimer interface [polypeptide binding]; other site 243243008280 substrate interaction site [chemical binding]; other site 243243008281 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243243008282 Uncharacterized conserved protein [Function unknown]; Region: COG0398 243243008283 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 243243008284 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 243243008285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243008286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243008287 dimerization interface [polypeptide binding]; other site 243243008288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243008289 dimer interface [polypeptide binding]; other site 243243008290 phosphorylation site [posttranslational modification] 243243008291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243008292 Mg2+ binding site [ion binding]; other site 243243008293 G-X-G motif; other site 243243008294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243008295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243008296 active site 243243008297 phosphorylation site [posttranslational modification] 243243008298 intermolecular recognition site; other site 243243008299 dimerization interface [polypeptide binding]; other site 243243008300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243008301 DNA binding site [nucleotide binding] 243243008302 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 243243008303 PknH-like extracellular domain; Region: PknH_C; pfam14032 243243008304 DoxX-like family; Region: DoxX_2; pfam13564 243243008305 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 243243008306 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 243243008307 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 243243008308 ferrochelatase; Reviewed; Region: hemH; PRK00035 243243008309 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 243243008310 C-terminal domain interface [polypeptide binding]; other site 243243008311 active site 243243008312 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 243243008313 active site 243243008314 N-terminal domain interface [polypeptide binding]; other site 243243008315 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 243243008316 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 243243008317 NAD binding site [chemical binding]; other site 243243008318 homotetramer interface [polypeptide binding]; other site 243243008319 homodimer interface [polypeptide binding]; other site 243243008320 substrate binding site [chemical binding]; other site 243243008321 active site 243243008322 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243243008323 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 243243008324 NAD(P) binding site [chemical binding]; other site 243243008325 homotetramer interface [polypeptide binding]; other site 243243008326 homodimer interface [polypeptide binding]; other site 243243008327 active site 243243008328 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 243243008329 hypothetical protein; Provisional; Region: PRK13685 243243008330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243243008331 metal ion-dependent adhesion site (MIDAS); other site 243243008332 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243243008333 Protein of unknown function DUF58; Region: DUF58; pfam01882 243243008334 MoxR-like ATPases [General function prediction only]; Region: COG0714 243243008335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243008336 Walker A motif; other site 243243008337 ATP binding site [chemical binding]; other site 243243008338 Walker B motif; other site 243243008339 arginine finger; other site 243243008340 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243243008341 NlpC/P60 family; Region: NLPC_P60; pfam00877 243243008342 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243243008343 NlpC/P60 family; Region: NLPC_P60; pfam00877 243243008344 aconitate hydratase; Validated; Region: PRK09277 243243008345 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 243243008346 substrate binding site [chemical binding]; other site 243243008347 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 243243008348 ligand binding site [chemical binding]; other site 243243008349 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 243243008350 substrate binding site [chemical binding]; other site 243243008351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243008352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243008353 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 243243008354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243008355 Walker A/P-loop; other site 243243008356 ATP binding site [chemical binding]; other site 243243008357 Q-loop/lid; other site 243243008358 ABC transporter signature motif; other site 243243008359 Walker B; other site 243243008360 D-loop; other site 243243008361 H-loop/switch region; other site 243243008362 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243243008363 enoyl-CoA hydratase; Provisional; Region: PRK05864 243243008364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243008365 substrate binding site [chemical binding]; other site 243243008366 oxyanion hole (OAH) forming residues; other site 243243008367 trimer interface [polypeptide binding]; other site 243243008368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243243008369 catalytic residues [active] 243243008370 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 243243008371 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 243243008372 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243008373 active site 243243008374 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 243243008375 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 243243008376 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 243243008377 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243243008378 trimerization site [polypeptide binding]; other site 243243008379 active site 243243008380 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243243008381 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 243243008382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243008383 catalytic residue [active] 243243008384 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 243243008385 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 243243008386 Walker A/P-loop; other site 243243008387 ATP binding site [chemical binding]; other site 243243008388 Q-loop/lid; other site 243243008389 ABC transporter signature motif; other site 243243008390 Walker B; other site 243243008391 D-loop; other site 243243008392 H-loop/switch region; other site 243243008393 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 243243008394 FeS assembly protein SufD; Region: sufD; TIGR01981 243243008395 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 243243008396 FeS assembly protein SufB; Region: sufB; TIGR01980 243243008397 Predicted transcriptional regulator [Transcription]; Region: COG2345 243243008398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243243008399 putative DNA binding site [nucleotide binding]; other site 243243008400 putative Zn2+ binding site [ion binding]; other site 243243008401 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 243243008402 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243243008403 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243243008404 Walker A/P-loop; other site 243243008405 ATP binding site [chemical binding]; other site 243243008406 Q-loop/lid; other site 243243008407 ABC transporter signature motif; other site 243243008408 Walker B; other site 243243008409 D-loop; other site 243243008410 H-loop/switch region; other site 243243008411 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243243008412 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 243243008413 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 243243008414 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 243243008415 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 243243008416 NADP binding site [chemical binding]; other site 243243008417 dimer interface [polypeptide binding]; other site 243243008418 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 243243008419 UbiA prenyltransferase family; Region: UbiA; pfam01040 243243008420 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 243243008421 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243243008422 TPP-binding site [chemical binding]; other site 243243008423 dimer interface [polypeptide binding]; other site 243243008424 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243243008425 PYR/PP interface [polypeptide binding]; other site 243243008426 dimer interface [polypeptide binding]; other site 243243008427 TPP binding site [chemical binding]; other site 243243008428 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243243008429 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 243243008430 putative active site [active] 243243008431 transaldolase; Provisional; Region: PRK03903 243243008432 catalytic residue [active] 243243008433 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 243243008434 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 243243008435 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 243243008436 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 243243008437 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 243243008438 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 243243008439 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 243243008440 putative active site [active] 243243008441 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 243243008442 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 243243008443 putative active site [active] 243243008444 Zn binding site [ion binding]; other site 243243008445 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243008446 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243008447 active site 243243008448 catalytic tetrad [active] 243243008449 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 243243008450 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 243243008451 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 243243008452 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 243243008453 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243008454 Preprotein translocase SecG subunit; Region: SecG; cl09123 243243008455 triosephosphate isomerase; Provisional; Region: PRK14567 243243008456 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 243243008457 substrate binding site [chemical binding]; other site 243243008458 dimer interface [polypeptide binding]; other site 243243008459 catalytic triad [active] 243243008460 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 243243008461 Phosphoglycerate kinase; Region: PGK; pfam00162 243243008462 substrate binding site [chemical binding]; other site 243243008463 hinge regions; other site 243243008464 ADP binding site [chemical binding]; other site 243243008465 catalytic site [active] 243243008466 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 243243008467 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 243243008468 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 243243008469 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 243243008470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243008471 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 243243008472 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243008473 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 243243008474 putative acyl-acceptor binding pocket; other site 243243008475 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243008476 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 243243008477 Winged helix-turn helix; Region: HTH_29; pfam13551 243243008478 Integrase core domain; Region: rve; pfam00665 243243008479 Integrase core domain; Region: rve_3; pfam13683 243243008480 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 243243008481 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243008482 acyl-activating enzyme (AAE) consensus motif; other site 243243008483 putative AMP binding site [chemical binding]; other site 243243008484 putative active site [active] 243243008485 putative CoA binding site [chemical binding]; other site 243243008486 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243008487 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243008488 substrate binding pocket [chemical binding]; other site 243243008489 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243008490 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 243243008491 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243008492 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243008493 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243008494 PPE family; Region: PPE; pfam00823 243243008495 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243008496 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243008497 PPE family; Region: PPE; pfam00823 243243008498 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243008499 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243008500 PPE family; Region: PPE; pfam00823 243243008501 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243008502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 243243008503 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 243243008504 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 243243008505 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 243243008506 phosphate binding site [ion binding]; other site 243243008507 putative substrate binding pocket [chemical binding]; other site 243243008508 dimer interface [polypeptide binding]; other site 243243008509 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 243243008510 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 243243008511 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243243008512 active site 243243008513 GIY-YIG motif/motif A; other site 243243008514 catalytic site [active] 243243008515 putative DNA binding site [nucleotide binding]; other site 243243008516 metal binding site [ion binding]; metal-binding site 243243008517 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 243243008518 Helix-hairpin-helix motif; Region: HHH; pfam00633 243243008519 helix-hairpin-helix signature motif; other site 243243008520 Cupin superfamily protein; Region: Cupin_4; pfam08007 243243008521 Cupin-like domain; Region: Cupin_8; pfam13621 243243008522 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 243243008523 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 243243008524 homopentamer interface [polypeptide binding]; other site 243243008525 active site 243243008526 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 243243008527 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 243243008528 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 243243008529 dimerization interface [polypeptide binding]; other site 243243008530 active site 243243008531 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 243243008532 Lumazine binding domain; Region: Lum_binding; pfam00677 243243008533 Lumazine binding domain; Region: Lum_binding; pfam00677 243243008534 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 243243008535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243008536 putative substrate translocation pore; other site 243243008537 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243243008538 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 243243008539 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 243243008540 catalytic motif [active] 243243008541 Zn binding site [ion binding]; other site 243243008542 RibD C-terminal domain; Region: RibD_C; pfam01872 243243008543 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 243243008544 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 243243008545 substrate binding site [chemical binding]; other site 243243008546 hexamer interface [polypeptide binding]; other site 243243008547 metal binding site [ion binding]; metal-binding site 243243008548 16S rRNA methyltransferase B; Provisional; Region: PRK14902 243243008549 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 243243008550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243008551 S-adenosylmethionine binding site [chemical binding]; other site 243243008552 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 243243008553 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 243243008554 putative active site [active] 243243008555 substrate binding site [chemical binding]; other site 243243008556 putative cosubstrate binding site; other site 243243008557 catalytic site [active] 243243008558 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 243243008559 substrate binding site [chemical binding]; other site 243243008560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243008561 S-adenosylmethionine binding site [chemical binding]; other site 243243008562 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243008563 MarR family; Region: MarR; pfam01047 243243008564 primosome assembly protein PriA; Provisional; Region: PRK14873 243243008565 Predicted membrane protein [Function unknown]; Region: COG3714 243243008566 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243008567 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243008568 substrate binding pocket [chemical binding]; other site 243243008569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243008570 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243008571 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243008572 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243008573 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 243243008574 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 243243008575 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 243243008576 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 243243008577 AsnC family; Region: AsnC_trans_reg; pfam01037 243243008578 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243243008579 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 243243008580 S-adenosylmethionine synthetase; Validated; Region: PRK05250 243243008581 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 243243008582 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 243243008583 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 243243008584 Flavoprotein; Region: Flavoprotein; pfam02441 243243008585 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 243243008586 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 243243008587 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 243243008588 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 243243008589 catalytic site [active] 243243008590 G-X2-G-X-G-K; other site 243243008591 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 243243008592 DNA binding residues [nucleotide binding] 243243008593 TOBE domain; Region: TOBE; cl01440 243243008594 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 243243008595 active site 243243008596 dimer interface [polypeptide binding]; other site 243243008597 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 243243008598 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243243008599 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243243008600 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 243243008601 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243243008602 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243243008603 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 243243008604 IMP binding site; other site 243243008605 dimer interface [polypeptide binding]; other site 243243008606 interdomain contacts; other site 243243008607 partial ornithine binding site; other site 243243008608 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 243243008609 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 243243008610 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 243243008611 catalytic site [active] 243243008612 subunit interface [polypeptide binding]; other site 243243008613 dihydroorotase; Validated; Region: pyrC; PRK09357 243243008614 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243008615 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 243243008616 active site 243243008617 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 243243008618 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243243008619 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243243008620 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 243243008621 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243243008622 active site 243243008623 Beta-lactamase; Region: Beta-lactamase; pfam00144 243243008624 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243243008625 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243243008626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243243008627 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 243243008628 L-aspartate oxidase; Provisional; Region: PRK06175 243243008629 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243243008630 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243243008631 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243243008632 Walker A/P-loop; other site 243243008633 ATP binding site [chemical binding]; other site 243243008634 Q-loop/lid; other site 243243008635 ABC transporter signature motif; other site 243243008636 Walker B; other site 243243008637 D-loop; other site 243243008638 H-loop/switch region; other site 243243008639 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 243243008640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243008641 dimer interface [polypeptide binding]; other site 243243008642 conserved gate region; other site 243243008643 putative PBP binding loops; other site 243243008644 ABC-ATPase subunit interface; other site 243243008645 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 243243008646 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 243243008647 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243243008648 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243243008649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243008650 DNA-binding site [nucleotide binding]; DNA binding site 243243008651 UTRA domain; Region: UTRA; pfam07702 243243008652 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243243008653 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243243008654 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243243008655 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 243243008656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243008657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243008658 active site 243243008659 phosphorylation site [posttranslational modification] 243243008660 intermolecular recognition site; other site 243243008661 dimerization interface [polypeptide binding]; other site 243243008662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243008663 DNA binding site [nucleotide binding] 243243008664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243008665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243008666 dimerization interface [polypeptide binding]; other site 243243008667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243008668 dimer interface [polypeptide binding]; other site 243243008669 phosphorylation site [posttranslational modification] 243243008670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243008671 ATP binding site [chemical binding]; other site 243243008672 Mg2+ binding site [ion binding]; other site 243243008673 G-X-G motif; other site 243243008674 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 243243008675 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243008676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243008677 catalytic residue [active] 243243008678 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 243243008679 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 243243008680 putative RNA binding site [nucleotide binding]; other site 243243008681 elongation factor P; Validated; Region: PRK00529 243243008682 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243243008683 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243243008684 RNA binding site [nucleotide binding]; other site 243243008685 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243243008686 RNA binding site [nucleotide binding]; other site 243243008687 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243243008688 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243243008689 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 243243008690 active site 243243008691 Dehydroquinase class II; Region: DHquinase_II; pfam01220 243243008692 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 243243008693 trimer interface [polypeptide binding]; other site 243243008694 active site 243243008695 dimer interface [polypeptide binding]; other site 243243008696 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 243243008697 active site 243243008698 dimer interface [polypeptide binding]; other site 243243008699 metal binding site [ion binding]; metal-binding site 243243008700 shikimate kinase; Reviewed; Region: aroK; PRK00131 243243008701 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 243243008702 ADP binding site [chemical binding]; other site 243243008703 magnesium binding site [ion binding]; other site 243243008704 putative shikimate binding site; other site 243243008705 chorismate synthase; Validated; Region: PRK05382 243243008706 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 243243008707 Tetramer interface [polypeptide binding]; other site 243243008708 active site 243243008709 FMN-binding site [chemical binding]; other site 243243008710 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 243243008711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243243008712 Walker A/P-loop; other site 243243008713 ATP binding site [chemical binding]; other site 243243008714 Q-loop/lid; other site 243243008715 ABC transporter signature motif; other site 243243008716 Walker B; other site 243243008717 D-loop; other site 243243008718 H-loop/switch region; other site 243243008719 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243243008720 Walker A/P-loop; other site 243243008721 ATP binding site [chemical binding]; other site 243243008722 Q-loop/lid; other site 243243008723 ABC transporter signature motif; other site 243243008724 Walker B; other site 243243008725 D-loop; other site 243243008726 H-loop/switch region; other site 243243008727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 243243008728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243243008729 dimer interface [polypeptide binding]; other site 243243008730 conserved gate region; other site 243243008731 putative PBP binding loops; other site 243243008732 ABC-ATPase subunit interface; other site 243243008733 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243243008734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 243243008735 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 243243008736 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 243243008737 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243008738 active site 243243008739 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243243008740 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243243008741 active site 243243008742 non-prolyl cis peptide bond; other site 243243008743 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 243243008744 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 243243008745 active site 243243008746 dimer interface [polypeptide binding]; other site 243243008747 non-prolyl cis peptide bond; other site 243243008748 insertion regions; other site 243243008749 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 243243008750 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 243243008751 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 243243008752 NAD(P) binding site [chemical binding]; other site 243243008753 shikimate binding site; other site 243243008754 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 243243008755 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 243243008756 dimerization interface [polypeptide binding]; other site 243243008757 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 243243008758 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 243243008759 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 243243008760 motif 1; other site 243243008761 active site 243243008762 motif 2; other site 243243008763 motif 3; other site 243243008764 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 243243008765 DHHA1 domain; Region: DHHA1; pfam02272 243243008766 Uncharacterized conserved protein [Function unknown]; Region: COG0432 243243008767 recombination factor protein RarA; Reviewed; Region: PRK13342 243243008768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243008769 Walker A motif; other site 243243008770 ATP binding site [chemical binding]; other site 243243008771 Walker B motif; other site 243243008772 arginine finger; other site 243243008773 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 243243008774 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 243243008775 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 243243008776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 243243008777 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 243243008778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 243243008779 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 243243008780 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243243008781 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 243243008782 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243243008783 Protein of unknown function (DUF419); Region: DUF419; cl15265 243243008784 Predicted membrane protein [Function unknown]; Region: COG4129 243243008785 Domain of unknown function (DUF385); Region: DUF385; pfam04075 243243008786 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 243243008787 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 243243008788 dimer interface [polypeptide binding]; other site 243243008789 anticodon binding site; other site 243243008790 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243243008791 homodimer interface [polypeptide binding]; other site 243243008792 motif 1; other site 243243008793 active site 243243008794 motif 2; other site 243243008795 GAD domain; Region: GAD; pfam02938 243243008796 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243243008797 active site 243243008798 motif 3; other site 243243008799 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 243243008800 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243243008801 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243243008802 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 243243008803 putative hydrophobic ligand binding site [chemical binding]; other site 243243008804 protein interface [polypeptide binding]; other site 243243008805 gate; other site 243243008806 Predicted metalloprotease [General function prediction only]; Region: COG2321 243243008807 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 243243008808 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 243243008809 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 243243008810 inhibitor site; inhibition site 243243008811 active site 243243008812 dimer interface [polypeptide binding]; other site 243243008813 catalytic residue [active] 243243008814 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 243243008815 intersubunit interface [polypeptide binding]; other site 243243008816 active site 243243008817 Zn2+ binding site [ion binding]; other site 243243008818 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243243008819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243008820 non-specific DNA binding site [nucleotide binding]; other site 243243008821 salt bridge; other site 243243008822 sequence-specific DNA binding site [nucleotide binding]; other site 243243008823 Cupin domain; Region: Cupin_2; pfam07883 243243008824 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243243008825 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243243008826 active site 243243008827 metal binding site [ion binding]; metal-binding site 243243008828 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 243243008829 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243243008830 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243008831 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243008832 active site 243243008833 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 243243008834 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243243008835 dimer interface [polypeptide binding]; other site 243243008836 motif 1; other site 243243008837 active site 243243008838 motif 2; other site 243243008839 motif 3; other site 243243008840 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 243243008841 anticodon binding site; other site 243243008842 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 243243008843 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 243243008844 active site 243243008845 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243008846 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243243008847 active site 243243008848 ATP binding site [chemical binding]; other site 243243008849 substrate binding site [chemical binding]; other site 243243008850 activation loop (A-loop); other site 243243008851 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 243243008852 active site 243243008853 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 243243008854 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243243008855 Zn2+ binding site [ion binding]; other site 243243008856 Mg2+ binding site [ion binding]; other site 243243008857 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243243008858 synthetase active site [active] 243243008859 NTP binding site [chemical binding]; other site 243243008860 metal binding site [ion binding]; metal-binding site 243243008861 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 243243008862 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 243243008863 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243243008864 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 243243008865 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 243243008866 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 243243008867 Protein export membrane protein; Region: SecD_SecF; pfam02355 243243008868 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 243243008869 Protein export membrane protein; Region: SecD_SecF; cl14618 243243008870 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 243243008871 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 243243008872 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243243008873 inhibitor-cofactor binding pocket; inhibition site 243243008874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243008875 catalytic residue [active] 243243008876 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 243243008877 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243008878 acyl-activating enzyme (AAE) consensus motif; other site 243243008879 AMP binding site [chemical binding]; other site 243243008880 active site 243243008881 CoA binding site [chemical binding]; other site 243243008882 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 243243008883 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 243243008884 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 243243008885 putative NAD(P) binding site [chemical binding]; other site 243243008886 active site 243243008887 putative substrate binding site [chemical binding]; other site 243243008888 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 243243008889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243008890 Walker A motif; other site 243243008891 ATP binding site [chemical binding]; other site 243243008892 Walker B motif; other site 243243008893 arginine finger; other site 243243008894 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 243243008895 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 243243008896 RuvA N terminal domain; Region: RuvA_N; pfam01330 243243008897 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 243243008898 active site 243243008899 putative DNA-binding cleft [nucleotide binding]; other site 243243008900 dimer interface [polypeptide binding]; other site 243243008901 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 243243008902 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 243243008903 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 243243008904 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 243243008905 spermidine synthase; Provisional; Region: PRK03612 243243008906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243008907 hypothetical protein; Validated; Region: PRK00110 243243008908 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 243243008909 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 243243008910 predicted active site [active] 243243008911 catalytic triad [active] 243243008912 acyl-CoA thioesterase II; Region: tesB; TIGR00189 243243008913 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 243243008914 active site 243243008915 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 243243008916 catalytic triad [active] 243243008917 dimer interface [polypeptide binding]; other site 243243008918 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 243243008919 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 243243008920 active site 243243008921 multimer interface [polypeptide binding]; other site 243243008922 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 243243008923 nudix motif; other site 243243008924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243008925 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243243008926 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 243243008927 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 243243008928 putative acyl-acceptor binding pocket; other site 243243008929 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 243243008930 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 243243008931 nucleotide binding site/active site [active] 243243008932 HIT family signature motif; other site 243243008933 catalytic residue [active] 243243008934 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 243243008935 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 243243008936 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 243243008937 active site 243243008938 dimer interface [polypeptide binding]; other site 243243008939 motif 1; other site 243243008940 motif 2; other site 243243008941 motif 3; other site 243243008942 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 243243008943 anticodon binding site; other site 243243008944 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 243243008945 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 243243008946 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 243243008947 metal binding site [ion binding]; metal-binding site 243243008948 putative dimer interface [polypeptide binding]; other site 243243008949 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243008950 CoenzymeA binding site [chemical binding]; other site 243243008951 subunit interaction site [polypeptide binding]; other site 243243008952 PHB binding site; other site 243243008953 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243008954 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243008955 active site 243243008956 catalytic tetrad [active] 243243008957 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 243243008958 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243008959 FMN binding site [chemical binding]; other site 243243008960 substrate binding site [chemical binding]; other site 243243008961 putative catalytic residue [active] 243243008962 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 243243008963 Helix-turn-helix domain; Region: HTH_20; pfam12840 243243008964 Predicted transcriptional regulator [Transcription]; Region: COG2345 243243008965 Ferredoxin [Energy production and conversion]; Region: COG1146 243243008966 4Fe-4S binding domain; Region: Fer4; pfam00037 243243008967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243243008968 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 243243008969 tetramer interface [polypeptide binding]; other site 243243008970 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 243243008971 active site 243243008972 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 243243008973 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 243243008974 active site 243243008975 Hemerythrin-like domain; Region: Hr-like; cd12108 243243008976 Fe binding site [ion binding]; other site 243243008977 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 243243008978 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243243008979 iron-sulfur cluster [ion binding]; other site 243243008980 [2Fe-2S] cluster binding site [ion binding]; other site 243243008981 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 243243008982 alpha subunit interaction site [polypeptide binding]; other site 243243008983 beta subunit interaction site [polypeptide binding]; other site 243243008984 iron-sulfur cluster [ion binding]; other site 243243008985 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 243243008986 beta subunit interface [polypeptide binding]; other site 243243008987 alpha subunit interface [polypeptide binding]; other site 243243008988 active site 243243008989 substrate binding site [chemical binding]; other site 243243008990 Fe binding site [ion binding]; other site 243243008991 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 243243008992 inter-subunit interface; other site 243243008993 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 243243008994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243008995 NAD(P) binding site [chemical binding]; other site 243243008996 active site 243243008997 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 243243008998 intersubunit interface [polypeptide binding]; other site 243243008999 active site 243243009000 Zn2+ binding site [ion binding]; other site 243243009001 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243243009002 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243243009003 Bacterial transcriptional regulator; Region: IclR; pfam01614 243243009004 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 243243009005 active site 243243009006 catalytic triad [active] 243243009007 oxyanion hole [active] 243243009008 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243243009009 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 243243009010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243009011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243009012 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243009013 anti sigma factor interaction site; other site 243243009014 regulatory phosphorylation site [posttranslational modification]; other site 243243009015 Predicted permeases [General function prediction only]; Region: COG0730 243243009016 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 243243009017 putative heme binding pocket [chemical binding]; other site 243243009018 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243009019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243009020 NAD(P) binding site [chemical binding]; other site 243243009021 active site 243243009022 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243243009023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243009024 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243009025 acyl-activating enzyme (AAE) consensus motif; other site 243243009026 acyl-activating enzyme (AAE) consensus motif; other site 243243009027 putative AMP binding site [chemical binding]; other site 243243009028 putative active site [active] 243243009029 putative CoA binding site [chemical binding]; other site 243243009030 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243009031 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243009032 substrate binding site [chemical binding]; other site 243243009033 oxyanion hole (OAH) forming residues; other site 243243009034 trimer interface [polypeptide binding]; other site 243243009035 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243243009036 hydrophobic ligand binding site; other site 243243009037 transposase; Provisional; Region: PRK06526 243243009038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243009039 Walker A motif; other site 243243009040 ATP binding site [chemical binding]; other site 243243009041 Walker B motif; other site 243243009042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 243243009043 Integrase core domain; Region: rve; pfam00665 243243009044 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243009045 MULE transposase domain; Region: MULE; pfam10551 243243009046 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243009047 MULE transposase domain; Region: MULE; pfam10551 243243009048 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243009049 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243009050 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 243243009051 hypothetical protein; Provisional; Region: PRK06194 243243009052 classical (c) SDRs; Region: SDR_c; cd05233 243243009053 NAD(P) binding site [chemical binding]; other site 243243009054 active site 243243009055 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243243009056 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243243009057 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243009058 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 243243009059 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243009060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243009061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243009062 short chain dehydrogenase; Provisional; Region: PRK12827 243243009063 classical (c) SDRs; Region: SDR_c; cd05233 243243009064 NAD(P) binding site [chemical binding]; other site 243243009065 active site 243243009066 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243009067 classical (c) SDRs; Region: SDR_c; cd05233 243243009068 NAD(P) binding site [chemical binding]; other site 243243009069 active site 243243009070 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 243243009071 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 243243009072 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243243009073 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243009074 NAD(P) binding site [chemical binding]; other site 243243009075 catalytic residues [active] 243243009076 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 243243009077 Cation efflux family; Region: Cation_efflux; cl00316 243243009078 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 243243009079 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243009080 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243009081 Clp amino terminal domain; Region: Clp_N; pfam02861 243243009082 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243243009083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243009084 Coenzyme A binding pocket [chemical binding]; other site 243243009085 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 243243009086 hypothetical protein; Provisional; Region: PRK14059 243243009087 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 243243009088 TAP-like protein; Region: Abhydrolase_4; pfam08386 243243009089 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 243243009090 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 243243009091 SelR domain; Region: SelR; pfam01641 243243009092 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243009093 MULE transposase domain; Region: MULE; pfam10551 243243009094 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243243009095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243009096 S-adenosylmethionine binding site [chemical binding]; other site 243243009097 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 243243009098 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 243243009099 substrate binding site [chemical binding]; other site 243243009100 active site 243243009101 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243009102 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243009103 substrate binding site [chemical binding]; other site 243243009104 oxyanion hole (OAH) forming residues; other site 243243009105 trimer interface [polypeptide binding]; other site 243243009106 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 243243009107 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 243243009108 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 243243009109 catalytic site [active] 243243009110 putative active site [active] 243243009111 putative substrate binding site [chemical binding]; other site 243243009112 Helicase and RNase D C-terminal; Region: HRDC; smart00341 243243009113 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 243243009114 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 243243009115 TPP-binding site; other site 243243009116 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243243009117 PYR/PP interface [polypeptide binding]; other site 243243009118 dimer interface [polypeptide binding]; other site 243243009119 TPP binding site [chemical binding]; other site 243243009120 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243243009121 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 243243009122 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 243243009123 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 243243009124 transmembrane helices; other site 243243009125 TRAM domain; Region: TRAM; pfam01938 243243009126 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 243243009127 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243243009128 TrkA-N domain; Region: TrkA_N; pfam02254 243243009129 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243243009130 TrkA-C domain; Region: TrkA_C; pfam02080 243243009131 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243243009132 TrkA-N domain; Region: TrkA_N; pfam02254 243243009133 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 243243009134 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 243243009135 generic binding surface II; other site 243243009136 ssDNA binding site; other site 243243009137 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243009138 MULE transposase domain; Region: MULE; pfam10551 243243009139 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 243243009140 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243243009141 trimer interface [polypeptide binding]; other site 243243009142 active site 243243009143 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 243243009144 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 243243009145 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 243243009146 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 243243009147 active site 243243009148 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243243009149 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243243009150 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 243243009151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243009152 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243243009153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243009154 DNA binding residues [nucleotide binding] 243243009155 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243009156 classical (c) SDRs; Region: SDR_c; cd05233 243243009157 NAD(P) binding site [chemical binding]; other site 243243009158 active site 243243009159 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 243243009160 homotrimer interaction site [polypeptide binding]; other site 243243009161 putative active site [active] 243243009162 Protein of unknown function (DUF952); Region: DUF952; cl01393 243243009163 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 243243009164 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 243243009165 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 243243009166 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 243243009167 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243243009168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243009169 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243243009170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243009171 DNA binding residues [nucleotide binding] 243243009172 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 243243009173 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 243243009174 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 243243009175 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 243243009176 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 243243009177 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 243243009178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243009179 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243009180 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243243009181 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 243243009182 PAC2 family; Region: PAC2; pfam09754 243243009183 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243009184 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 243243009185 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 243243009186 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 243243009187 heme-binding site [chemical binding]; other site 243243009188 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 243243009189 ATP cone domain; Region: ATP-cone; pfam03477 243243009190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 243243009191 LexA repressor; Validated; Region: PRK00215 243243009192 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 243243009193 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243243009194 Catalytic site [active] 243243009195 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 243243009196 LGFP repeat; Region: LGFP; pfam08310 243243009197 LGFP repeat; Region: LGFP; pfam08310 243243009198 LGFP repeat; Region: LGFP; pfam08310 243243009199 LGFP repeat; Region: LGFP; pfam08310 243243009200 LGFP repeat; Region: LGFP; pfam08310 243243009201 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243009202 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243009203 active site 243243009204 GTPases [General function prediction only]; Region: HflX; COG2262 243243009205 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 243243009206 HflX GTPase family; Region: HflX; cd01878 243243009207 G1 box; other site 243243009208 GTP/Mg2+ binding site [chemical binding]; other site 243243009209 Switch I region; other site 243243009210 G2 box; other site 243243009211 G3 box; other site 243243009212 Switch II region; other site 243243009213 G4 box; other site 243243009214 G5 box; other site 243243009215 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 243243009216 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243243009217 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243243009218 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 243243009219 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 243243009220 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 243243009221 active site 243243009222 metal binding site [ion binding]; metal-binding site 243243009223 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243009224 MULE transposase domain; Region: MULE; pfam10551 243243009225 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 243243009226 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 243243009227 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 243243009228 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243243009229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243243009230 FeS/SAM binding site; other site 243243009231 recombination regulator RecX; Reviewed; Region: recX; PRK00117 243243009232 recombinase A; Provisional; Region: recA; PRK09354 243243009233 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 243243009234 hexamer interface [polypeptide binding]; other site 243243009235 Walker A motif; other site 243243009236 ATP binding site [chemical binding]; other site 243243009237 Walker B motif; other site 243243009238 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 243243009239 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 243243009240 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 243243009241 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 243243009242 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243243009243 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 243243009244 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 243243009245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243009246 non-specific DNA binding site [nucleotide binding]; other site 243243009247 salt bridge; other site 243243009248 sequence-specific DNA binding site [nucleotide binding]; other site 243243009249 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 243243009250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243009251 Coenzyme A binding pocket [chemical binding]; other site 243243009252 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 243243009253 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243243009254 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 243243009255 Uncharacterized conserved protein [Function unknown]; Region: COG1359 243243009256 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 243243009257 classical (c) SDRs; Region: SDR_c; cd05233 243243009258 NAD(P) binding site [chemical binding]; other site 243243009259 active site 243243009260 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243009261 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243009262 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 243243009263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243009264 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 243243009265 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 243243009266 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 243243009267 dimer interface [polypeptide binding]; other site 243243009268 active site 243243009269 catalytic residue [active] 243243009270 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 243243009271 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 243243009272 DivIVA protein; Region: DivIVA; pfam05103 243243009273 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 243243009274 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 243243009275 folate binding site [chemical binding]; other site 243243009276 NADP+ binding site [chemical binding]; other site 243243009277 thymidylate synthase; Reviewed; Region: thyA; PRK01827 243243009278 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 243243009279 dimerization interface [polypeptide binding]; other site 243243009280 active site 243243009281 Dienelactone hydrolase family; Region: DLH; pfam01738 243243009282 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 243243009283 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243243009284 active site 243243009285 TDP-binding site; other site 243243009286 acceptor substrate-binding pocket; other site 243243009287 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 243243009288 classical (c) SDRs; Region: SDR_c; cd05233 243243009289 NAD(P) binding site [chemical binding]; other site 243243009290 active site 243243009291 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 243243009292 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243243009293 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243243009294 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243243009295 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 243243009296 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243243009297 carboxyltransferase (CT) interaction site; other site 243243009298 biotinylation site [posttranslational modification]; other site 243243009299 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 243243009300 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243243009301 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243009302 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243009303 acyl-activating enzyme (AAE) consensus motif; other site 243243009304 AMP binding site [chemical binding]; other site 243243009305 active site 243243009306 CoA binding site [chemical binding]; other site 243243009307 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 243243009308 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243009309 active site 2 [active] 243243009310 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 243243009311 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243243009312 dihydrodipicolinate reductase; Provisional; Region: PRK00048 243243009313 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243243009314 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 243243009315 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243009316 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243009317 active site 243243009318 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243009319 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 243243009320 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243009321 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243009322 [2Fe-2S] cluster binding site [ion binding]; other site 243243009323 Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...; Region: Bcl-2_like; cl02575 243243009324 BH3; other site 243243009325 BH3-homology region binding site; other site 243243009326 BH1; other site 243243009327 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 243243009328 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 243243009329 FMN-binding pocket [chemical binding]; other site 243243009330 flavin binding motif; other site 243243009331 phosphate binding motif [ion binding]; other site 243243009332 beta-alpha-beta structure motif; other site 243243009333 NAD binding pocket [chemical binding]; other site 243243009334 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243009335 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243243009336 catalytic loop [active] 243243009337 iron binding site [ion binding]; other site 243243009338 short chain dehydrogenase; Validated; Region: PRK05855 243243009339 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243009340 classical (c) SDRs; Region: SDR_c; cd05233 243243009341 NAD(P) binding site [chemical binding]; other site 243243009342 active site 243243009343 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 243243009344 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 243243009345 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 243243009346 hydrophobic ligand binding site; other site 243243009347 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 243243009348 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 243243009349 hexamer interface [polypeptide binding]; other site 243243009350 ligand binding site [chemical binding]; other site 243243009351 putative active site [active] 243243009352 NAD(P) binding site [chemical binding]; other site 243243009353 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 243243009354 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243009355 FMN binding site [chemical binding]; other site 243243009356 substrate binding site [chemical binding]; other site 243243009357 putative catalytic residue [active] 243243009358 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243243009359 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243243009360 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243243009361 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 243243009362 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 243243009363 oligomer interface [polypeptide binding]; other site 243243009364 RNA binding site [nucleotide binding]; other site 243243009365 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 243243009366 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 243243009367 RNase E interface [polypeptide binding]; other site 243243009368 trimer interface [polypeptide binding]; other site 243243009369 active site 243243009370 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 243243009371 putative nucleic acid binding region [nucleotide binding]; other site 243243009372 G-X-X-G motif; other site 243243009373 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 243243009374 RNA binding site [nucleotide binding]; other site 243243009375 domain interface; other site 243243009376 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 243243009377 16S/18S rRNA binding site [nucleotide binding]; other site 243243009378 S13e-L30e interaction site [polypeptide binding]; other site 243243009379 25S rRNA binding site [nucleotide binding]; other site 243243009380 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 243243009381 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 243243009382 active site 243243009383 Riboflavin kinase; Region: Flavokinase; smart00904 243243009384 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 243243009385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243243009386 putative DNA binding site [nucleotide binding]; other site 243243009387 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 243243009388 FeoA domain; Region: FeoA; pfam04023 243243009389 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243009390 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243009391 active site 243243009392 lipid-transfer protein; Provisional; Region: PRK08256 243243009393 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243009394 active site 243243009395 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 243243009396 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 243243009397 RNA binding site [nucleotide binding]; other site 243243009398 active site 243243009399 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 243243009400 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 243243009401 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 243243009402 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 243243009403 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243243009404 active site 243243009405 metal binding site [ion binding]; metal-binding site 243243009406 Predicted acyl esterases [General function prediction only]; Region: COG2936 243243009407 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 243243009408 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 243243009409 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 243243009410 enoyl-CoA hydratase; Provisional; Region: PRK06190 243243009411 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243009412 substrate binding site [chemical binding]; other site 243243009413 oxyanion hole (OAH) forming residues; other site 243243009414 trimer interface [polypeptide binding]; other site 243243009415 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 243243009416 DHH family; Region: DHH; pfam01368 243243009417 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 243243009418 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243243009419 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243243009420 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 243243009421 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 243243009422 G1 box; other site 243243009423 putative GEF interaction site [polypeptide binding]; other site 243243009424 GTP/Mg2+ binding site [chemical binding]; other site 243243009425 G3 box; other site 243243009426 Switch II region; other site 243243009427 G4 box; other site 243243009428 G5 box; other site 243243009429 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 243243009430 Translation-initiation factor 2; Region: IF-2; pfam11987 243243009431 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 243243009432 Protein of unknown function (DUF448); Region: DUF448; pfam04296 243243009433 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 243243009434 NusA N-terminal domain; Region: NusA_N; pfam08529 243243009435 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 243243009436 RNA binding site [nucleotide binding]; other site 243243009437 homodimer interface [polypeptide binding]; other site 243243009438 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243243009439 G-X-X-G motif; other site 243243009440 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243243009441 G-X-X-G motif; other site 243243009442 ribosome maturation protein RimP; Reviewed; Region: PRK00092 243243009443 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 243243009444 putative oligomer interface [polypeptide binding]; other site 243243009445 putative RNA binding site [nucleotide binding]; other site 243243009446 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243243009447 dinuclear metal binding motif [ion binding]; other site 243243009448 prolyl-tRNA synthetase; Provisional; Region: PRK09194 243243009449 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 243243009450 dimer interface [polypeptide binding]; other site 243243009451 motif 1; other site 243243009452 active site 243243009453 motif 2; other site 243243009454 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 243243009455 putative deacylase active site [active] 243243009456 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243243009457 active site 243243009458 motif 3; other site 243243009459 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 243243009460 anticodon binding site; other site 243243009461 hypothetical protein; Provisional; Region: PRK01346 243243009462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 243243009463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243009464 putative substrate translocation pore; other site 243243009465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243009466 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 243243009467 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 243243009468 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 243243009469 active site 243243009470 SAM binding site [chemical binding]; other site 243243009471 homodimer interface [polypeptide binding]; other site 243243009472 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 243243009473 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 243243009474 catalytic triad [active] 243243009475 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 243243009476 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 243243009477 Walker A motif; other site 243243009478 homodimer interface [polypeptide binding]; other site 243243009479 ATP binding site [chemical binding]; other site 243243009480 hydroxycobalamin binding site [chemical binding]; other site 243243009481 Walker B motif; other site 243243009482 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 243243009483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 243243009484 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 243243009485 metal ion-dependent adhesion site (MIDAS); other site 243243009486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243009487 Coenzyme A binding pocket [chemical binding]; other site 243243009488 malate:quinone oxidoreductase; Validated; Region: PRK05257 243243009489 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 243243009490 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 243243009491 mycothione reductase; Reviewed; Region: PRK07846 243243009492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243009493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243009494 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243243009495 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 243243009496 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 243243009497 Uncharacterized conserved protein [Function unknown]; Region: COG3379 243243009498 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243009499 PPE family; Region: PPE; pfam00823 243243009500 short chain dehydrogenase; Provisional; Region: PRK06057 243243009501 classical (c) SDRs; Region: SDR_c; cd05233 243243009502 NAD(P) binding site [chemical binding]; other site 243243009503 active site 243243009504 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 243243009505 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 243243009506 catalytic triad [active] 243243009507 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 243243009508 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 243243009509 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243243009510 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243009511 cobyric acid synthase; Provisional; Region: PRK00784 243243009512 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243243009513 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243243009514 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 243243009515 catalytic triad [active] 243243009516 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243243009517 active site 243243009518 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 243243009519 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243243009520 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243243009521 Predicted acetyltransferase [General function prediction only]; Region: COG3393 243243009522 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 243243009523 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 243243009524 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 243243009525 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 243243009526 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 243243009527 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 243243009528 active site 243243009529 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243243009530 protein binding site [polypeptide binding]; other site 243243009531 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243243009532 putative substrate binding region [chemical binding]; other site 243243009533 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 243243009534 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 243243009535 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 243243009536 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 243243009537 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 243243009538 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 243243009539 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243243009540 catalytic residues [active] 243243009541 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 243243009542 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 243243009543 ribosome recycling factor; Reviewed; Region: frr; PRK00083 243243009544 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 243243009545 hinge region; other site 243243009546 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 243243009547 putative nucleotide binding site [chemical binding]; other site 243243009548 uridine monophosphate binding site [chemical binding]; other site 243243009549 homohexameric interface [polypeptide binding]; other site 243243009550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243009551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243009552 DNA binding site [nucleotide binding] 243243009553 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243009554 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 243243009555 putative acyl-acceptor binding pocket; other site 243243009556 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 243243009557 ChaB; Region: ChaB; pfam06150 243243009558 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 243243009559 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243009560 MarR family; Region: MarR; pfam01047 243243009561 elongation factor Ts; Provisional; Region: tsf; PRK09377 243243009562 UBA/TS-N domain; Region: UBA; pfam00627 243243009563 Elongation factor TS; Region: EF_TS; pfam00889 243243009564 Elongation factor TS; Region: EF_TS; pfam00889 243243009565 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 243243009566 rRNA interaction site [nucleotide binding]; other site 243243009567 S8 interaction site; other site 243243009568 putative laminin-1 binding site; other site 243243009569 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 243243009570 Peptidase family M23; Region: Peptidase_M23; pfam01551 243243009571 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 243243009572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243243009573 active site 243243009574 DNA binding site [nucleotide binding] 243243009575 Int/Topo IB signature motif; other site 243243009576 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 243243009577 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 243243009578 putative active site [active] 243243009579 putative substrate binding site [chemical binding]; other site 243243009580 putative FMN binding site [chemical binding]; other site 243243009581 putative catalytic residues [active] 243243009582 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 243243009583 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 243243009584 FAD binding pocket [chemical binding]; other site 243243009585 FAD binding motif [chemical binding]; other site 243243009586 phosphate binding motif [ion binding]; other site 243243009587 NAD binding pocket [chemical binding]; other site 243243009588 DNA protecting protein DprA; Region: dprA; TIGR00732 243243009589 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 243243009590 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 243243009591 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 243243009592 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243243009593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243009594 Walker A motif; other site 243243009595 ATP binding site [chemical binding]; other site 243243009596 Walker B motif; other site 243243009597 arginine finger; other site 243243009598 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 243243009599 hypothetical protein; Reviewed; Region: PRK12497 243243009600 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 243243009601 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243009602 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 243243009603 putative NAD(P) binding site [chemical binding]; other site 243243009604 active site 243243009605 putative substrate binding site [chemical binding]; other site 243243009606 ANTAR domain; Region: ANTAR; pfam03861 243243009607 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 243243009608 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 243243009609 RNA/DNA hybrid binding site [nucleotide binding]; other site 243243009610 active site 243243009611 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 243243009612 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243243009613 Catalytic site [active] 243243009614 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243243009615 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 243243009616 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243243009617 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 243243009618 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 243243009619 RimM N-terminal domain; Region: RimM; pfam01782 243243009620 PRC-barrel domain; Region: PRC; pfam05239 243243009621 hypothetical protein; Provisional; Region: PRK02821 243243009622 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 243243009623 G-X-X-G motif; other site 243243009624 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 243243009625 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 243243009626 SnoaL-like domain; Region: SnoaL_3; pfam13474 243243009627 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243243009628 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243243009629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243009630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243009631 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 243243009632 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243009633 active site 243243009634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243009635 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 243243009636 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243009637 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 243243009638 active site 243243009639 signal recognition particle protein; Provisional; Region: PRK10867 243243009640 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 243243009641 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243243009642 P loop; other site 243243009643 GTP binding site [chemical binding]; other site 243243009644 Signal peptide binding domain; Region: SRP_SPB; pfam02978 243243009645 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243009646 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 243243009647 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 243243009648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243009649 ATP binding site [chemical binding]; other site 243243009650 putative Mg++ binding site [ion binding]; other site 243243009651 PII uridylyl-transferase; Provisional; Region: PRK03381 243243009652 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243243009653 metal binding triad; other site 243243009654 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243243009655 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243243009656 Zn2+ binding site [ion binding]; other site 243243009657 Mg2+ binding site [ion binding]; other site 243243009658 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 243243009659 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243243009660 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243243009661 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243243009662 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 243243009663 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 243243009664 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243243009665 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243243009666 AAA domain; Region: AAA_23; pfam13476 243243009667 Walker A/P-loop; other site 243243009668 ATP binding site [chemical binding]; other site 243243009669 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243243009670 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 243243009671 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243243009672 ABC transporter signature motif; other site 243243009673 Walker B; other site 243243009674 D-loop; other site 243243009675 H-loop/switch region; other site 243243009676 acylphosphatase; Provisional; Region: PRK14422 243243009677 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 243243009678 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 243243009679 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 243243009680 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 243243009681 DNA binding site [nucleotide binding] 243243009682 catalytic residue [active] 243243009683 H2TH interface [polypeptide binding]; other site 243243009684 putative catalytic residues [active] 243243009685 turnover-facilitating residue; other site 243243009686 intercalation triad [nucleotide binding]; other site 243243009687 8OG recognition residue [nucleotide binding]; other site 243243009688 putative reading head residues; other site 243243009689 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243243009690 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243243009691 ribonuclease III; Reviewed; Region: rnc; PRK00102 243243009692 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 243243009693 dimerization interface [polypeptide binding]; other site 243243009694 active site 243243009695 metal binding site [ion binding]; metal-binding site 243243009696 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 243243009697 dsRNA binding site [nucleotide binding]; other site 243243009698 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 243243009699 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 243243009700 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 243243009701 Predicted permease; Region: DUF318; cl17795 243243009702 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 243243009703 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243243009704 PYR/PP interface [polypeptide binding]; other site 243243009705 dimer interface [polypeptide binding]; other site 243243009706 TPP binding site [chemical binding]; other site 243243009707 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243243009708 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 243243009709 TPP-binding site [chemical binding]; other site 243243009710 dimer interface [polypeptide binding]; other site 243243009711 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243009712 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 243243009713 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 243243009714 catalytic residues [active] 243243009715 Recombinase; Region: Recombinase; pfam07508 243243009716 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 243243009717 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 243243009718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243009719 ATP binding site [chemical binding]; other site 243243009720 Walker B motif; other site 243243009721 arginine finger; other site 243243009722 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 243243009723 active site 243243009724 catalytic triad [active] 243243009725 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243243009726 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 243243009727 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243009728 non-specific DNA binding site [nucleotide binding]; other site 243243009729 salt bridge; other site 243243009730 sequence-specific DNA binding site [nucleotide binding]; other site 243243009731 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 243243009732 nudix motif; other site 243243009733 HD domain; Region: HD; pfam01966 243243009734 Zn2+ binding site [ion binding]; other site 243243009735 Mg2+ binding site [ion binding]; other site 243243009736 RNA ligase, Rnl2 family; Region: RNA_lig_RNL2; TIGR02307 243243009737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243009738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243009739 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243009740 CoenzymeA binding site [chemical binding]; other site 243243009741 subunit interaction site [polypeptide binding]; other site 243243009742 PHB binding site; other site 243243009743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243009744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243009745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243009746 active site 243243009747 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 243243009748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 243243009749 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243243009750 active site 243243009751 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243243009752 non-prolyl cis peptide bond; other site 243243009753 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 243243009754 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 243243009755 active site 243243009756 (T/H)XGH motif; other site 243243009757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243243009758 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 243243009759 S-adenosylmethionine binding site [chemical binding]; other site 243243009760 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 243243009761 putative active site [active] 243243009762 redox center [active] 243243009763 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 243243009764 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 243243009765 catalytic residues [active] 243243009766 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243009767 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243009768 substrate binding pocket [chemical binding]; other site 243243009769 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 243243009770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243009771 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243009772 active site 243243009773 catalytic tetrad [active] 243243009774 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 243243009775 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 243243009776 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 243243009777 ssDNA binding site; other site 243243009778 generic binding surface II; other site 243243009779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243009780 ATP binding site [chemical binding]; other site 243243009781 putative Mg++ binding site [ion binding]; other site 243243009782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243009783 nucleotide binding region [chemical binding]; other site 243243009784 ATP-binding site [chemical binding]; other site 243243009785 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 243243009786 DAK2 domain; Region: Dak2; pfam02734 243243009787 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 243243009788 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243009789 classical (c) SDRs; Region: SDR_c; cd05233 243243009790 NAD(P) binding site [chemical binding]; other site 243243009791 active site 243243009792 short chain dehydrogenase; Provisional; Region: PRK06197 243243009793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243009794 NAD(P) binding site [chemical binding]; other site 243243009795 active site 243243009796 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 243243009797 short chain dehydrogenase; Provisional; Region: PRK06180 243243009798 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 243243009799 NADP binding site [chemical binding]; other site 243243009800 active site 243243009801 steroid binding site; other site 243243009802 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 243243009803 ligand binding site [chemical binding]; other site 243243009804 active site 243243009805 UGI interface [polypeptide binding]; other site 243243009806 catalytic site [active] 243243009807 thiamine monophosphate kinase; Provisional; Region: PRK05731 243243009808 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 243243009809 ATP binding site [chemical binding]; other site 243243009810 dimerization interface [polypeptide binding]; other site 243243009811 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 243243009812 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 243243009813 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 243243009814 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 243243009815 polyphosphate kinase; Provisional; Region: PRK05443 243243009816 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 243243009817 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 243243009818 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 243243009819 putative domain interface [polypeptide binding]; other site 243243009820 putative active site [active] 243243009821 catalytic site [active] 243243009822 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 243243009823 putative domain interface [polypeptide binding]; other site 243243009824 putative active site [active] 243243009825 catalytic site [active] 243243009826 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 243243009827 active site 243243009828 Ap6A binding site [chemical binding]; other site 243243009829 nudix motif; other site 243243009830 metal binding site [ion binding]; metal-binding site 243243009831 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243009832 catalytic core [active] 243243009833 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243243009834 IHF - DNA interface [nucleotide binding]; other site 243243009835 IHF dimer interface [polypeptide binding]; other site 243243009836 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 243243009837 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 243243009838 substrate binding site [chemical binding]; other site 243243009839 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 243243009840 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 243243009841 substrate binding site [chemical binding]; other site 243243009842 ligand binding site [chemical binding]; other site 243243009843 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243243009844 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243243009845 Bacterial transcriptional regulator; Region: IclR; pfam01614 243243009846 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 243243009847 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 243243009848 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243243009849 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243243009850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243009851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243243009852 putative substrate translocation pore; other site 243243009853 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 243243009854 tartrate dehydrogenase; Region: TTC; TIGR02089 243243009855 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 243243009856 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 243243009857 ligand binding site [chemical binding]; other site 243243009858 NAD binding site [chemical binding]; other site 243243009859 dimerization interface [polypeptide binding]; other site 243243009860 catalytic site [active] 243243009861 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 243243009862 putative L-serine binding site [chemical binding]; other site 243243009863 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 243243009864 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243009865 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 243243009866 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243243009867 ketol-acid reductoisomerase; Provisional; Region: PRK05479 243243009868 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 243243009869 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 243243009870 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 243243009871 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 243243009872 putative valine binding site [chemical binding]; other site 243243009873 dimer interface [polypeptide binding]; other site 243243009874 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 243243009875 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 243243009876 Predicted membrane protein [Function unknown]; Region: COG2259 243243009877 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 243243009878 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 243243009879 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 243243009880 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 243243009881 GatB domain; Region: GatB_Yqey; smart00845 243243009882 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 243243009883 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243243009884 P-loop; other site 243243009885 Magnesium ion binding site [ion binding]; other site 243243009886 6-phosphofructokinase; Provisional; Region: PRK03202 243243009887 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 243243009888 active site 243243009889 ADP/pyrophosphate binding site [chemical binding]; other site 243243009890 dimerization interface [polypeptide binding]; other site 243243009891 allosteric effector site; other site 243243009892 fructose-1,6-bisphosphate binding site; other site 243243009893 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 243243009894 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 243243009895 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 243243009896 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 243243009897 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 243243009898 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243009899 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243243009900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243009901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243009902 cystathionine gamma-lyase; Validated; Region: PRK07582 243243009903 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243243009904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243009905 catalytic residue [active] 243243009906 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 243243009907 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 243243009908 nucleotide binding pocket [chemical binding]; other site 243243009909 K-X-D-G motif; other site 243243009910 catalytic site [active] 243243009911 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 243243009912 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 243243009913 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243243009914 Dimer interface [polypeptide binding]; other site 243243009915 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 243243009916 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 243243009917 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 243243009918 Ligand Binding Site [chemical binding]; other site 243243009919 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243243009920 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243243009921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243243009922 catalytic residue [active] 243243009923 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243009924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243243009925 putative acyl-acceptor binding pocket; other site 243243009926 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 243243009927 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 243243009928 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 243243009929 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 243243009930 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 243243009931 Ligand binding site [chemical binding]; other site 243243009932 Electron transfer flavoprotein domain; Region: ETF; pfam01012 243243009933 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243243009934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243009935 S-adenosylmethionine binding site [chemical binding]; other site 243243009936 Uncharacterized conserved protein [Function unknown]; Region: COG1543 243243009937 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 243243009938 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 243243009939 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243009940 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243243009941 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 243243009942 putative hydrophobic ligand binding site [chemical binding]; other site 243243009943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243009944 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 243243009945 NAD(P) binding site [chemical binding]; other site 243243009946 active site 243243009947 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243009948 anti sigma factor interaction site; other site 243243009949 regulatory phosphorylation site [posttranslational modification]; other site 243243009950 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243243009951 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243243009952 substrate binding pocket [chemical binding]; other site 243243009953 chain length determination region; other site 243243009954 substrate-Mg2+ binding site; other site 243243009955 catalytic residues [active] 243243009956 aspartate-rich region 1; other site 243243009957 active site lid residues [active] 243243009958 aspartate-rich region 2; other site 243243009959 phytoene desaturase; Region: crtI_fam; TIGR02734 243243009960 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 243243009961 active site lid residues [active] 243243009962 substrate binding pocket [chemical binding]; other site 243243009963 catalytic residues [active] 243243009964 substrate-Mg2+ binding site; other site 243243009965 aspartate-rich region 1; other site 243243009966 aspartate-rich region 2; other site 243243009967 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 243243009968 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 243243009969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243243009970 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 243243009971 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243243009972 [2Fe-2S] cluster binding site [ion binding]; other site 243243009973 iron-sulfur cluster [ion binding]; other site 243243009974 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243009975 MarR family; Region: MarR_2; pfam12802 243243009976 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 243243009977 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 243243009978 homotetramer interface [polypeptide binding]; other site 243243009979 FMN binding site [chemical binding]; other site 243243009980 homodimer contacts [polypeptide binding]; other site 243243009981 putative active site [active] 243243009982 putative substrate binding site [chemical binding]; other site 243243009983 MMPL family; Region: MMPL; pfam03176 243243009984 TspO/MBR family; Region: TspO_MBR; cl01379 243243009985 TspO/MBR family; Region: TspO_MBR; cl01379 243243009986 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 243243009987 DNA photolyase; Region: DNA_photolyase; pfam00875 243243009988 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 243243009989 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 243243009990 trimer interface [polypeptide binding]; other site 243243009991 active site 243243009992 substrate binding site [chemical binding]; other site 243243009993 CoA binding site [chemical binding]; other site 243243009994 FOG: WD40-like repeat [Function unknown]; Region: COG1520 243243009995 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 243243009996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243009997 S-adenosylmethionine binding site [chemical binding]; other site 243243009998 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243009999 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 243243010000 substrate binding site [chemical binding]; other site 243243010001 oxyanion hole (OAH) forming residues; other site 243243010002 trimer interface [polypeptide binding]; other site 243243010003 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 243243010004 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 243243010005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243010006 Walker A/P-loop; other site 243243010007 ATP binding site [chemical binding]; other site 243243010008 ABC transporter signature motif; other site 243243010009 Walker B; other site 243243010010 D-loop; other site 243243010011 H-loop/switch region; other site 243243010012 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 243243010013 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 243243010014 phosphoserine phosphatase SerB; Region: serB; TIGR00338 243243010015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243010016 motif II; other site 243243010017 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 243243010018 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 243243010019 D-pathway; other site 243243010020 Putative ubiquinol binding site [chemical binding]; other site 243243010021 Low-spin heme (heme b) binding site [chemical binding]; other site 243243010022 Putative water exit pathway; other site 243243010023 Binuclear center (heme o3/CuB) [ion binding]; other site 243243010024 K-pathway; other site 243243010025 Putative proton exit pathway; other site 243243010026 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 243243010027 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 243243010028 siderophore binding site; other site 243243010029 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243243010030 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 243243010031 putative NAD(P) binding site [chemical binding]; other site 243243010032 putative substrate binding site [chemical binding]; other site 243243010033 catalytic Zn binding site [ion binding]; other site 243243010034 structural Zn binding site [ion binding]; other site 243243010035 dimer interface [polypeptide binding]; other site 243243010036 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 243243010037 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 243243010038 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 243243010039 dimer interface [polypeptide binding]; other site 243243010040 putative radical transfer pathway; other site 243243010041 diiron center [ion binding]; other site 243243010042 tyrosyl radical; other site 243243010043 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 243243010044 putative hydrophobic ligand binding site [chemical binding]; other site 243243010045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010047 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243010048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243010049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010051 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 243243010052 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 243243010053 Class I ribonucleotide reductase; Region: RNR_I; cd01679 243243010054 active site 243243010055 dimer interface [polypeptide binding]; other site 243243010056 catalytic residues [active] 243243010057 effector binding site; other site 243243010058 R2 peptide binding site; other site 243243010059 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 243243010060 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 243243010061 catalytic residues [active] 243243010062 Predicted flavoprotein [General function prediction only]; Region: COG0431 243243010063 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243243010064 DNA polymerase IV; Validated; Region: PRK03352 243243010065 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243243010066 active site 243243010067 DNA binding site [nucleotide binding] 243243010068 short chain dehydrogenase; Provisional; Region: PRK07832 243243010069 classical (c) SDRs; Region: SDR_c; cd05233 243243010070 NAD(P) binding site [chemical binding]; other site 243243010071 active site 243243010072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010074 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243010075 Cytochrome P450; Region: p450; cl12078 243243010076 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 243243010077 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 243243010078 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243243010079 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 243243010080 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243243010081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243010082 DNA-binding site [nucleotide binding]; DNA binding site 243243010083 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 243243010084 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243243010085 FCD domain; Region: FCD; pfam07729 243243010086 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243010087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243010088 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243010089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243010090 active site 243243010091 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243010092 active site 243243010093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243010094 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 243243010095 NAD(P) binding site [chemical binding]; other site 243243010096 active site 243243010097 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 243243010098 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 243243010099 active site 243243010100 DNA binding site [nucleotide binding] 243243010101 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 243243010102 DNA binding site [nucleotide binding] 243243010103 carbon starvation protein A; Provisional; Region: PRK15015 243243010104 Carbon starvation protein CstA; Region: CstA; pfam02554 243243010105 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 243243010106 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 243243010107 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 243243010108 nucleotide binding site [chemical binding]; other site 243243010109 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243243010110 SBD interface [polypeptide binding]; other site 243243010111 enoyl-CoA hydratase; Provisional; Region: PRK05864 243243010112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243010113 substrate binding site [chemical binding]; other site 243243010114 oxyanion hole (OAH) forming residues; other site 243243010115 trimer interface [polypeptide binding]; other site 243243010116 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243010117 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243010118 active site 243243010119 MspA; Region: MspA; pfam09203 243243010120 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243010121 Phosphotransferase enzyme family; Region: APH; pfam01636 243243010122 putative active site [active] 243243010123 putative substrate binding site [chemical binding]; other site 243243010124 ATP binding site [chemical binding]; other site 243243010125 short chain dehydrogenase; Provisional; Region: PRK07326 243243010126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243010127 NAD(P) binding site [chemical binding]; other site 243243010128 active site 243243010129 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243010130 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 243243010131 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243010132 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243243010133 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243243010134 Walker A/P-loop; other site 243243010135 ATP binding site [chemical binding]; other site 243243010136 Q-loop/lid; other site 243243010137 ABC transporter signature motif; other site 243243010138 Walker B; other site 243243010139 D-loop; other site 243243010140 H-loop/switch region; other site 243243010141 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243243010142 ABC transporter; Region: ABC_tran; pfam00005 243243010143 Q-loop/lid; other site 243243010144 ABC transporter signature motif; other site 243243010145 Walker B; other site 243243010146 D-loop; other site 243243010147 H-loop/switch region; other site 243243010148 Cobalt transport protein; Region: CbiQ; cl00463 243243010149 enolase; Provisional; Region: eno; PRK00077 243243010150 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243243010151 dimer interface [polypeptide binding]; other site 243243010152 metal binding site [ion binding]; metal-binding site 243243010153 substrate binding pocket [chemical binding]; other site 243243010154 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243010155 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243010156 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 243243010157 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 243243010158 substrate binding pocket [chemical binding]; other site 243243010159 active site 243243010160 iron coordination sites [ion binding]; other site 243243010161 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 243243010162 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243010163 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243010164 [2Fe-2S] cluster binding site [ion binding]; other site 243243010165 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 243243010166 alpha subunit interface [polypeptide binding]; other site 243243010167 active site 243243010168 substrate binding site [chemical binding]; other site 243243010169 Fe binding site [ion binding]; other site 243243010170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243010171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243010172 NAD(P) binding site [chemical binding]; other site 243243010173 active site 243243010174 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 243243010175 beta-alpha-beta structure motif; other site 243243010176 NAD binding pocket [chemical binding]; other site 243243010177 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243243010178 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243010179 catalytic loop [active] 243243010180 iron binding site [ion binding]; other site 243243010181 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243010182 MarR family; Region: MarR_2; pfam12802 243243010183 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243010184 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243010185 [2Fe-2S] cluster binding site [ion binding]; other site 243243010186 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 243243010187 alpha subunit interface [polypeptide binding]; other site 243243010188 active site 243243010189 substrate binding site [chemical binding]; other site 243243010190 Fe binding site [ion binding]; other site 243243010191 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243010192 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 243243010193 NAD binding site [chemical binding]; other site 243243010194 catalytic residues [active] 243243010195 Fic/DOC family; Region: Fic; cl00960 243243010196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243010197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243243010198 putative substrate translocation pore; other site 243243010199 camphor resistance protein CrcB; Provisional; Region: PRK14216 243243010200 camphor resistance protein CrcB; Provisional; Region: PRK14228 243243010201 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 243243010202 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 243243010203 Uncharacterized conserved protein [Function unknown]; Region: COG3189 243243010204 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243010205 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243010206 active site 243243010207 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 243243010208 Hemerythrin-like domain; Region: Hr-like; cd12108 243243010209 Fe binding site [ion binding]; other site 243243010210 Uncharacterized conserved protein [Function unknown]; Region: COG0397 243243010211 hypothetical protein; Validated; Region: PRK00029 243243010212 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 243243010213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010214 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 243243010215 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243010216 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 243243010217 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 243243010218 putative active site [active] 243243010219 catalytic site [active] 243243010220 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 243243010221 putative active site [active] 243243010222 catalytic site [active] 243243010223 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 243243010224 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 243243010225 Beta-lactamase; Region: Beta-lactamase; pfam00144 243243010226 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 243243010227 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 243243010228 active site 243243010229 TDP-binding site; other site 243243010230 Methyltransferase domain; Region: Methyltransf_24; pfam13578 243243010231 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243010232 MULE transposase domain; Region: MULE; pfam10551 243243010233 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cl00482 243243010234 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 243243010235 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 243243010236 FtsX-like permease family; Region: FtsX; pfam02687 243243010237 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 243243010238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243010239 Walker A/P-loop; other site 243243010240 ATP binding site [chemical binding]; other site 243243010241 Q-loop/lid; other site 243243010242 ABC transporter signature motif; other site 243243010243 Walker B; other site 243243010244 D-loop; other site 243243010245 H-loop/switch region; other site 243243010246 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243243010247 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243243010248 peptide chain release factor 2; Validated; Region: prfB; PRK00578 243243010249 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243243010250 RF-1 domain; Region: RF-1; pfam00472 243243010251 ferredoxin-NADP+ reductase; Region: PLN02852 243243010252 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 243243010253 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 243243010254 heme-binding site [chemical binding]; other site 243243010255 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243243010256 Ligand Binding Site [chemical binding]; other site 243243010257 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 243243010258 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 243243010259 Binuclear center (active site) [active] 243243010260 K-pathway; other site 243243010261 Putative proton exit pathway; other site 243243010262 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243243010263 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 243243010264 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 243243010265 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243010266 PPE family; Region: PPE; pfam00823 243243010267 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243010268 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243010269 PPE family; Region: PPE; pfam00823 243243010270 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 243243010271 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 243243010272 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243243010273 active site 243243010274 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243010275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243010276 active site 243243010277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243010278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243010279 active site 243243010280 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243243010281 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 243243010282 NAD(P) binding site [chemical binding]; other site 243243010283 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 243243010284 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243243010285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243010286 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243243010287 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243010288 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243010289 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243010290 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 243243010291 active site 243243010292 catalytic residues [active] 243243010293 metal binding site [ion binding]; metal-binding site 243243010294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010296 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243010297 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 243243010298 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 243243010299 active site 243243010300 Phosphotransferase enzyme family; Region: APH; pfam01636 243243010301 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243010302 putative active site [active] 243243010303 putative substrate binding site [chemical binding]; other site 243243010304 ATP binding site [chemical binding]; other site 243243010305 YceI-like domain; Region: YceI; pfam04264 243243010306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 243243010307 phosphorylation site [posttranslational modification] 243243010308 intermolecular recognition site; other site 243243010309 NADH dehydrogenase subunit A; Validated; Region: PRK07928 243243010310 NADH dehydrogenase subunit B; Validated; Region: PRK06411 243243010311 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 243243010312 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 243243010313 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 243243010314 NADH dehydrogenase subunit D; Validated; Region: PRK06075 243243010315 NADH dehydrogenase subunit E; Validated; Region: PRK07539 243243010316 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 243243010317 putative dimer interface [polypeptide binding]; other site 243243010318 [2Fe-2S] cluster binding site [ion binding]; other site 243243010319 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 243243010320 SLBB domain; Region: SLBB; pfam10531 243243010321 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 243243010322 NADH dehydrogenase subunit G; Validated; Region: PRK07860 243243010323 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243010324 catalytic loop [active] 243243010325 iron binding site [ion binding]; other site 243243010326 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243243010327 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243010328 molybdopterin cofactor binding site; other site 243243010329 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 243243010330 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 243243010331 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 243243010332 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 243243010333 4Fe-4S binding domain; Region: Fer4; pfam00037 243243010334 4Fe-4S binding domain; Region: Fer4; pfam00037 243243010335 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 243243010336 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 243243010337 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 243243010338 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243243010339 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243243010340 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 243243010341 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243243010342 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 243243010343 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243243010344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010345 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243010346 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 243243010347 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243243010348 Protein of unknown function DUF58; Region: DUF58; pfam01882 243243010349 MoxR-like ATPases [General function prediction only]; Region: COG0714 243243010350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243010351 Walker A motif; other site 243243010352 ATP binding site [chemical binding]; other site 243243010353 Walker B motif; other site 243243010354 arginine finger; other site 243243010355 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 243243010356 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243010357 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243010358 active site 243243010359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243010360 NAD(P) binding site [chemical binding]; other site 243243010361 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 243243010362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243010363 active site 243243010364 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 243243010365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010366 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243010367 putative active site [active] 243243010368 putative substrate binding site [chemical binding]; other site 243243010369 ATP binding site [chemical binding]; other site 243243010370 Phosphotransferase enzyme family; Region: APH; pfam01636 243243010371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243010372 metabolite-proton symporter; Region: 2A0106; TIGR00883 243243010373 putative substrate translocation pore; other site 243243010374 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 243243010375 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 243243010376 active site 243243010377 non-prolyl cis peptide bond; other site 243243010378 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 243243010379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243010380 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243010381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243010382 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 243243010383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243243010384 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243243010385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243243010386 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243243010387 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243010388 CheB methylesterase; Region: CheB_methylest; pfam01339 243243010389 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243243010390 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 243243010391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243010392 S-adenosylmethionine binding site [chemical binding]; other site 243243010393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243243010394 PAS domain; Region: PAS_9; pfam13426 243243010395 putative active site [active] 243243010396 heme pocket [chemical binding]; other site 243243010397 PAS domain; Region: PAS; smart00091 243243010398 PAS domain; Region: PAS_9; pfam13426 243243010399 putative active site [active] 243243010400 heme pocket [chemical binding]; other site 243243010401 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243010402 anti sigma factor interaction site; other site 243243010403 regulatory phosphorylation site [posttranslational modification]; other site 243243010404 hydroperoxidase II; Provisional; Region: katE; PRK11249 243243010405 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 243243010406 tetramer interface [polypeptide binding]; other site 243243010407 heme binding pocket [chemical binding]; other site 243243010408 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 243243010409 domain interactions; other site 243243010410 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 243243010411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243010412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243010413 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 243243010414 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243243010415 putative metal binding site [ion binding]; other site 243243010416 putative metal binding site [ion binding]; other site 243243010417 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 243243010418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243010419 NADH(P)-binding; Region: NAD_binding_10; pfam13460 243243010420 NAD(P) binding site [chemical binding]; other site 243243010421 active site 243243010422 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243243010423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243010424 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 243243010425 putative ADP-binding pocket [chemical binding]; other site 243243010426 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243243010427 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243010428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243010429 NAD(P) binding site [chemical binding]; other site 243243010430 active site 243243010431 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 243243010432 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 243243010433 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243243010434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243010435 active site 243243010436 motif I; other site 243243010437 motif II; other site 243243010438 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243243010439 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243243010440 putative active site [active] 243243010441 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 243243010442 dimer interface [polypeptide binding]; other site 243243010443 active site 243243010444 classical (c) SDRs; Region: SDR_c; cd05233 243243010445 NAD(P) binding site [chemical binding]; other site 243243010446 active site 243243010447 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243243010448 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243243010449 putative active site [active] 243243010450 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 243243010451 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243243010452 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243243010453 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 243243010454 thiamine pyrophosphate protein; Provisional; Region: PRK08273 243243010455 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 243243010456 PYR/PP interface [polypeptide binding]; other site 243243010457 dimer interface [polypeptide binding]; other site 243243010458 tetramer interface [polypeptide binding]; other site 243243010459 TPP binding site [chemical binding]; other site 243243010460 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243243010461 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 243243010462 TPP-binding site [chemical binding]; other site 243243010463 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 243243010464 Fe-S cluster binding site [ion binding]; other site 243243010465 active site 243243010466 Hemerythrin-like domain; Region: Hr-like; cd12108 243243010467 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 243243010468 PknH-like extracellular domain; Region: PknH_C; pfam14032 243243010469 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243010470 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243010471 active site 243243010472 catalytic tetrad [active] 243243010473 classical (c) SDRs; Region: SDR_c; cd05233 243243010474 NAD(P) binding site [chemical binding]; other site 243243010475 active site 243243010476 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 243243010477 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 243243010478 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 243243010479 active site 243243010480 catalytic site [active] 243243010481 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 243243010482 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243243010483 NAD binding site [chemical binding]; other site 243243010484 catalytic Zn binding site [ion binding]; other site 243243010485 structural Zn binding site [ion binding]; other site 243243010486 GAF domain; Region: GAF; cl17456 243243010487 GAF domain; Region: GAF_2; pfam13185 243243010488 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 243243010489 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243243010490 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 243243010491 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 243243010492 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243010493 DNA binding residues [nucleotide binding] 243243010494 putative dimer interface [polypeptide binding]; other site 243243010495 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243243010496 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243243010497 putative dimer interface [polypeptide binding]; other site 243243010498 PAS fold; Region: PAS_3; pfam08447 243243010499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243243010500 putative active site [active] 243243010501 heme pocket [chemical binding]; other site 243243010502 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 243243010503 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243243010504 GAF domain; Region: GAF; pfam01590 243243010505 GAF domain; Region: GAF_3; pfam13492 243243010506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 243243010507 Histidine kinase; Region: HisKA_3; pfam07730 243243010508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243010509 ATP binding site [chemical binding]; other site 243243010510 Mg2+ binding site [ion binding]; other site 243243010511 G-X-G motif; other site 243243010512 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243243010513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243010514 active site 243243010515 phosphorylation site [posttranslational modification] 243243010516 intermolecular recognition site; other site 243243010517 dimerization interface [polypeptide binding]; other site 243243010518 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243243010519 DNA binding residues [nucleotide binding] 243243010520 dimerization interface [polypeptide binding]; other site 243243010521 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 243243010522 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 243243010523 dimer interface [polypeptide binding]; other site 243243010524 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 243243010525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 243243010526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243010527 ATP binding site [chemical binding]; other site 243243010528 Mg2+ binding site [ion binding]; other site 243243010529 G-X-G motif; other site 243243010530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243243010531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243010532 active site 243243010533 phosphorylation site [posttranslational modification] 243243010534 intermolecular recognition site; other site 243243010535 dimerization interface [polypeptide binding]; other site 243243010536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243243010537 DNA binding residues [nucleotide binding] 243243010538 dimerization interface [polypeptide binding]; other site 243243010539 Acyltransferase family; Region: Acyl_transf_3; pfam01757 243243010540 yiaA/B two helix domain; Region: YiaAB; cl01759 243243010541 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 243243010542 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 243243010543 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 243243010544 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 243243010545 FMN-binding pocket [chemical binding]; other site 243243010546 flavin binding motif; other site 243243010547 phosphate binding motif [ion binding]; other site 243243010548 beta-alpha-beta structure motif; other site 243243010549 NAD binding pocket [chemical binding]; other site 243243010550 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243010551 catalytic loop [active] 243243010552 iron binding site [ion binding]; other site 243243010553 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243010554 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243010555 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 243243010556 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 243243010557 acyl-CoA synthetase; Validated; Region: PRK05850 243243010558 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 243243010559 acyl-activating enzyme (AAE) consensus motif; other site 243243010560 active site 243243010561 thioester reductase domain; Region: Thioester-redct; TIGR01746 243243010562 Male sterility protein; Region: NAD_binding_4; pfam07993 243243010563 NAD(P) binding site [chemical binding]; other site 243243010564 active site 243243010565 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 243243010566 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 243243010567 short chain dehydrogenase; Provisional; Region: PRK06197 243243010568 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 243243010569 putative NAD(P) binding site [chemical binding]; other site 243243010570 active site 243243010571 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243010572 mce related protein; Region: MCE; pfam02470 243243010573 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243010574 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243010575 mce related protein; Region: MCE; pfam02470 243243010576 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243010577 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243243010578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243243010579 metal binding site [ion binding]; metal-binding site 243243010580 active site 243243010581 I-site; other site 243243010582 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 243243010583 catalytic residues [active] 243243010584 dimer interface [polypeptide binding]; other site 243243010585 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 243243010586 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243010587 MULE transposase domain; Region: MULE; pfam10551 243243010588 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243010589 MULE transposase domain; Region: MULE; pfam10551 243243010590 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243010591 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 243243010592 hypothetical protein; Validated; Region: PRK00068 243243010593 Uncharacterized conserved protein [Function unknown]; Region: COG1615 243243010594 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 243243010595 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243243010596 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243243010597 Uncharacterized conserved protein [Function unknown]; Region: COG5282 243243010598 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 243243010599 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 243243010600 ABC1 family; Region: ABC1; pfam03109 243243010601 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 243243010602 active site 243243010603 ATP binding site [chemical binding]; other site 243243010604 Transcription factor WhiB; Region: Whib; pfam02467 243243010605 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 243243010606 Part of AAA domain; Region: AAA_19; pfam13245 243243010607 Family description; Region: UvrD_C_2; pfam13538 243243010608 HRDC domain; Region: HRDC; pfam00570 243243010609 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 243243010610 catalytic residues [active] 243243010611 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 243243010612 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 243243010613 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 243243010614 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 243243010615 putative NADH binding site [chemical binding]; other site 243243010616 putative active site [active] 243243010617 nudix motif; other site 243243010618 putative metal binding site [ion binding]; other site 243243010619 Ion channel; Region: Ion_trans_2; pfam07885 243243010620 TrkA-N domain; Region: TrkA_N; pfam02254 243243010621 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 243243010622 Part of AAA domain; Region: AAA_19; pfam13245 243243010623 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 243243010624 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 243243010625 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 243243010626 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 243243010627 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243010628 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243010629 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 243243010630 catalytic site [active] 243243010631 Latarcin precursor; Region: Latarcin; pfam10279 243243010632 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243243010633 active site 243243010634 DNA binding site [nucleotide binding] 243243010635 TIGR02569 family protein; Region: TIGR02569_actnb 243243010636 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 243243010637 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 243243010638 ATP binding site [chemical binding]; other site 243243010639 substrate interface [chemical binding]; other site 243243010640 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243243010641 active site residue [active] 243243010642 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 243243010643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010645 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 243243010646 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243243010647 dinuclear metal binding motif [ion binding]; other site 243243010648 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243243010649 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243243010650 P-loop; other site 243243010651 Magnesium ion binding site [ion binding]; other site 243243010652 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 243243010653 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243243010654 Magnesium ion binding site [ion binding]; other site 243243010655 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243010656 catalytic core [active] 243243010657 isochorismate synthase DhbC; Validated; Region: PRK06923 243243010658 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243243010659 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243243010660 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 243243010661 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 243243010662 Transcription factor WhiB; Region: Whib; pfam02467 243243010663 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 243243010664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 243243010665 Histidine kinase; Region: HisKA_2; pfam07568 243243010666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243010667 ATP binding site [chemical binding]; other site 243243010668 Mg2+ binding site [ion binding]; other site 243243010669 G-X-G motif; other site 243243010670 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243243010671 carboxyltransferase (CT) interaction site; other site 243243010672 biotinylation site [posttranslational modification]; other site 243243010673 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 243243010674 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243010675 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243010676 DNA binding residues [nucleotide binding] 243243010677 short chain dehydrogenase; Provisional; Region: PRK08278 243243010678 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 243243010679 NAD(P) binding site [chemical binding]; other site 243243010680 homodimer interface [polypeptide binding]; other site 243243010681 active site 243243010682 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243243010683 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243243010684 NAD(P) binding site [chemical binding]; other site 243243010685 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 243243010686 classical (c) SDRs; Region: SDR_c; cd05233 243243010687 tropinone reductase; Provisional; Region: PRK09242 243243010688 NAD(P) binding site [chemical binding]; other site 243243010689 active site 243243010690 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243010691 classical (c) SDRs; Region: SDR_c; cd05233 243243010692 NAD(P) binding site [chemical binding]; other site 243243010693 active site 243243010694 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243010695 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243010696 active site 243243010697 Uncharacterized conserved protein [Function unknown]; Region: COG2135 243243010698 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 243243010699 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 243243010700 hinge; other site 243243010701 active site 243243010702 Predicted GTPases [General function prediction only]; Region: COG1162 243243010703 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 243243010704 GTPase/Zn-binding domain interface [polypeptide binding]; other site 243243010705 GTP/Mg2+ binding site [chemical binding]; other site 243243010706 G4 box; other site 243243010707 G5 box; other site 243243010708 G1 box; other site 243243010709 Switch I region; other site 243243010710 G2 box; other site 243243010711 G3 box; other site 243243010712 Switch II region; other site 243243010713 Predicted transcriptional regulators [Transcription]; Region: COG1733 243243010714 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 243243010715 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 243243010716 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243010717 dimer interface [polypeptide binding]; other site 243243010718 active site 243243010719 Domain of unknown function DUF302; Region: DUF302; pfam03625 243243010720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010721 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 243243010722 DNA-binding interface [nucleotide binding]; DNA binding site 243243010723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010724 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 243243010725 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 243243010726 putative di-iron ligands [ion binding]; other site 243243010727 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 243243010728 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 243243010729 FAD binding pocket [chemical binding]; other site 243243010730 FAD binding motif [chemical binding]; other site 243243010731 phosphate binding motif [ion binding]; other site 243243010732 beta-alpha-beta structure motif; other site 243243010733 NAD binding pocket [chemical binding]; other site 243243010734 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243010735 catalytic loop [active] 243243010736 iron binding site [ion binding]; other site 243243010737 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 243243010738 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243010739 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243010740 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243243010741 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 243243010742 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 243243010743 TrkA-C domain; Region: TrkA_C; pfam02080 243243010744 Phospholipid methyltransferase; Region: PEMT; cl17370 243243010745 HD domain; Region: HD_5; pfam13487 243243010746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243243010747 Zn2+ binding site [ion binding]; other site 243243010748 Mg2+ binding site [ion binding]; other site 243243010749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243243010750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243243010751 DNA binding residues [nucleotide binding] 243243010752 dimerization interface [polypeptide binding]; other site 243243010753 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 243243010754 30S subunit binding site; other site 243243010755 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 243243010756 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 243243010757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243243010758 dimerization interface [polypeptide binding]; other site 243243010759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243010760 dimer interface [polypeptide binding]; other site 243243010761 phosphorylation site [posttranslational modification] 243243010762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243010763 ATP binding site [chemical binding]; other site 243243010764 Mg2+ binding site [ion binding]; other site 243243010765 G-X-G motif; other site 243243010766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243010767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243010768 active site 243243010769 phosphorylation site [posttranslational modification] 243243010770 intermolecular recognition site; other site 243243010771 dimerization interface [polypeptide binding]; other site 243243010772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243010773 DNA binding site [nucleotide binding] 243243010774 thymidylate kinase; Validated; Region: PRK07933 243243010775 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 243243010776 Adenosylhomocysteinase; Provisional; Region: PTZ00075 243243010777 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 243243010778 homotetramer interface [polypeptide binding]; other site 243243010779 ligand binding site [chemical binding]; other site 243243010780 catalytic site [active] 243243010781 NAD binding site [chemical binding]; other site 243243010782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010784 Rubredoxin [Energy production and conversion]; Region: COG1773 243243010785 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 243243010786 iron binding site [ion binding]; other site 243243010787 Rubredoxin [Energy production and conversion]; Region: COG1773 243243010788 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 243243010789 iron binding site [ion binding]; other site 243243010790 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 243243010791 Fatty acid desaturase; Region: FA_desaturase; pfam00487 243243010792 Di-iron ligands [ion binding]; other site 243243010793 amino acid transporter; Region: 2A0306; TIGR00909 243243010794 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 243243010795 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 243243010796 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 243243010797 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 243243010798 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 243243010799 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 243243010800 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 243243010801 Transcription factor WhiB; Region: Whib; pfam02467 243243010802 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 243243010803 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 243243010804 phosphate binding site [ion binding]; other site 243243010805 dimer interface [polypeptide binding]; other site 243243010806 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 243243010807 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 243243010808 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 243243010809 FMN binding site [chemical binding]; other site 243243010810 dimer interface [polypeptide binding]; other site 243243010811 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 243243010812 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243243010813 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 243243010814 nudix motif; other site 243243010815 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 243243010816 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 243243010817 active site 243243010818 Substrate binding site; other site 243243010819 Mg++ binding site; other site 243243010820 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 243243010821 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243243010822 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 243243010823 Probable Catalytic site; other site 243243010824 metal-binding site 243243010825 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 243243010826 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 243243010827 NADP binding site [chemical binding]; other site 243243010828 active site 243243010829 putative substrate binding site [chemical binding]; other site 243243010830 Transcriptional regulator [Transcription]; Region: LytR; COG1316 243243010831 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 243243010832 TIGR03089 family protein; Region: TIGR03089 243243010833 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 243243010834 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 243243010835 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243243010836 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243010837 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243010838 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243010839 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243010840 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243010841 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243243010842 active site 243243010843 ATP binding site [chemical binding]; other site 243243010844 substrate binding site [chemical binding]; other site 243243010845 activation loop (A-loop); other site 243243010846 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243243010847 NHL repeat; Region: NHL; pfam01436 243243010848 NHL repeat; Region: NHL; pfam01436 243243010849 NHL repeat; Region: NHL; pfam01436 243243010850 NHL repeat; Region: NHL; pfam01436 243243010851 NHL repeat; Region: NHL; pfam01436 243243010852 PBP superfamily domain; Region: PBP_like_2; cl17296 243243010853 Response regulator receiver domain; Region: Response_reg; pfam00072 243243010854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243010855 active site 243243010856 phosphorylation site [posttranslational modification] 243243010857 intermolecular recognition site; other site 243243010858 dimerization interface [polypeptide binding]; other site 243243010859 CHASE3 domain; Region: CHASE3; pfam05227 243243010860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243010861 HAMP domain; Region: HAMP; pfam00672 243243010862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243010863 dimer interface [polypeptide binding]; other site 243243010864 phosphorylation site [posttranslational modification] 243243010865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243010866 ATP binding site [chemical binding]; other site 243243010867 Mg2+ binding site [ion binding]; other site 243243010868 G-X-G motif; other site 243243010869 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 243243010870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243010871 active site 243243010872 phosphorylation site [posttranslational modification] 243243010873 intermolecular recognition site; other site 243243010874 dimerization interface [polypeptide binding]; other site 243243010875 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243243010876 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243010877 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 243243010878 FAD binding site [chemical binding]; other site 243243010879 homotetramer interface [polypeptide binding]; other site 243243010880 substrate binding pocket [chemical binding]; other site 243243010881 catalytic base [active] 243243010882 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 243243010883 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 243243010884 ATP-grasp domain; Region: ATP-grasp; pfam02222 243243010885 Predicted membrane protein [Function unknown]; Region: COG2246 243243010886 GtrA-like protein; Region: GtrA; pfam04138 243243010887 Bacterial PH domain; Region: DUF304; pfam03703 243243010888 biotin--protein ligase; Provisional; Region: PRK06955 243243010889 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 243243010890 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 243243010891 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 243243010892 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 243243010893 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 243243010894 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243243010895 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 243243010896 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 243243010897 Maf-like protein; Region: Maf; pfam02545 243243010898 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243243010899 active site 243243010900 dimer interface [polypeptide binding]; other site 243243010901 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243243010902 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 243243010903 active site residue [active] 243243010904 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 243243010905 active site residue [active] 243243010906 Fe-S metabolism associated domain; Region: SufE; cl00951 243243010907 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 243243010908 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243243010909 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 243243010910 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243243010911 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243243010912 carboxyltransferase (CT) interaction site; other site 243243010913 biotinylation site [posttranslational modification]; other site 243243010914 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243010915 anti sigma factor interaction site; other site 243243010916 regulatory phosphorylation site [posttranslational modification]; other site 243243010917 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 243243010918 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243010919 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243243010920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243010921 DNA binding residues [nucleotide binding] 243243010922 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 243243010923 L-lysine aminotransferase; Provisional; Region: PRK08297 243243010924 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243243010925 inhibitor-cofactor binding pocket; inhibition site 243243010926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243010927 catalytic residue [active] 243243010928 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 243243010929 AsnC family; Region: AsnC_trans_reg; pfam01037 243243010930 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 243243010931 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 243243010932 aldehyde dehydrogenase family 7 member; Region: PLN02315 243243010933 tetrameric interface [polypeptide binding]; other site 243243010934 NAD binding site [chemical binding]; other site 243243010935 catalytic residues [active] 243243010936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243010937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243010938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243010939 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 243243010940 ATP binding site [chemical binding]; other site 243243010941 putative Mg++ binding site [ion binding]; other site 243243010942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243010943 nucleotide binding region [chemical binding]; other site 243243010944 ATP-binding site [chemical binding]; other site 243243010945 DEAD/H associated; Region: DEAD_assoc; pfam08494 243243010946 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 243243010947 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243010948 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243010949 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243010950 PPE family; Region: PPE; pfam00823 243243010951 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243010952 PPE family; Region: PPE; pfam00823 243243010953 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 243243010954 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243243010955 active site 243243010956 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 243243010957 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 243243010958 putative active site pocket [active] 243243010959 dimerization interface [polypeptide binding]; other site 243243010960 putative catalytic residue [active] 243243010961 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 243243010962 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 243243010963 metal binding site [ion binding]; metal-binding site 243243010964 putative dimer interface [polypeptide binding]; other site 243243010965 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 243243010966 amidohydrolase; Region: amidohydrolases; TIGR01891 243243010967 metal binding site [ion binding]; metal-binding site 243243010968 Cutinase; Region: Cutinase; pfam01083 243243010969 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243243010970 purine nucleoside phosphorylase; Provisional; Region: PRK08202 243243010971 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 243243010972 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 243243010973 active site 243243010974 substrate binding site [chemical binding]; other site 243243010975 metal binding site [ion binding]; metal-binding site 243243010976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243243010977 active site 243243010978 Phosphoesterase family; Region: Phosphoesterase; pfam04185 243243010979 hypothetical protein; Provisional; Region: PRK13685 243243010980 von Willebrand factor type A domain; Region: VWA_2; pfam13519 243243010981 metal ion-dependent adhesion site (MIDAS); other site 243243010982 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243010983 MULE transposase domain; Region: MULE; pfam10551 243243010984 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243010985 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243010986 active site 243243010987 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 243243010988 adenosine deaminase; Provisional; Region: PRK09358 243243010989 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 243243010990 active site 243243010991 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 243243010992 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243243010993 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243243010994 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 243243010995 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 243243010996 active site 243243010997 catalytic motif [active] 243243010998 Zn binding site [ion binding]; other site 243243010999 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 243243011000 putative Iron-sulfur protein interface [polypeptide binding]; other site 243243011001 putative proximal heme binding site [chemical binding]; other site 243243011002 putative SdhD-like interface [polypeptide binding]; other site 243243011003 putative distal heme binding site [chemical binding]; other site 243243011004 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 243243011005 putative Iron-sulfur protein interface [polypeptide binding]; other site 243243011006 putative proximal heme binding site [chemical binding]; other site 243243011007 putative SdhC-like subunit interface [polypeptide binding]; other site 243243011008 putative distal heme binding site [chemical binding]; other site 243243011009 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 243243011010 L-aspartate oxidase; Provisional; Region: PRK06175 243243011011 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243243011012 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 243243011013 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 243243011014 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243011015 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 243243011016 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 243243011017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243011018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243011019 DNA binding residues [nucleotide binding] 243243011020 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 243243011021 hypothetical protein; Provisional; Region: PRK06541 243243011022 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243243011023 inhibitor-cofactor binding pocket; inhibition site 243243011024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243011025 catalytic residue [active] 243243011026 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243243011027 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243243011028 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 243243011029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243011030 putative substrate translocation pore; other site 243243011031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243011032 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 243243011033 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 243243011034 active site 243243011035 dimer interface [polypeptide binding]; other site 243243011036 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 243243011037 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 243243011038 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 243243011039 active site 243243011040 HIGH motif; other site 243243011041 dimer interface [polypeptide binding]; other site 243243011042 KMSKS motif; other site 243243011043 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243011044 isocitrate dehydrogenase; Validated; Region: PRK08299 243243011045 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 243243011046 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 243243011047 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 243243011048 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243243011049 homodimer interface [polypeptide binding]; other site 243243011050 substrate-cofactor binding pocket; other site 243243011051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243011052 catalytic residue [active] 243243011053 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 243243011054 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 243243011055 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243243011056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243011057 S-adenosylmethionine binding site [chemical binding]; other site 243243011058 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243011059 MULE transposase domain; Region: MULE; pfam10551 243243011060 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243011061 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 243243011062 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 243243011063 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 243243011064 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 243243011065 homodimer interface [polypeptide binding]; other site 243243011066 NADP binding site [chemical binding]; other site 243243011067 substrate binding site [chemical binding]; other site 243243011068 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 243243011069 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 243243011070 active site 243243011071 FMN binding site [chemical binding]; other site 243243011072 substrate binding site [chemical binding]; other site 243243011073 putative catalytic residue [active] 243243011074 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243011075 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243011076 phosphopeptide binding site; other site 243243011077 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243011078 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243011079 phosphopeptide binding site; other site 243243011080 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243243011081 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 243243011082 Walker A/P-loop; other site 243243011083 ATP binding site [chemical binding]; other site 243243011084 Q-loop/lid; other site 243243011085 ABC transporter signature motif; other site 243243011086 Walker B; other site 243243011087 D-loop; other site 243243011088 H-loop/switch region; other site 243243011089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243011090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243011091 phosphopeptide binding site; other site 243243011092 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 243243011093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 243243011094 phosphopeptide binding site; other site 243243011095 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243243011096 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 243243011097 Walker A/P-loop; other site 243243011098 ATP binding site [chemical binding]; other site 243243011099 Q-loop/lid; other site 243243011100 ABC transporter signature motif; other site 243243011101 Walker B; other site 243243011102 D-loop; other site 243243011103 H-loop/switch region; other site 243243011104 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243243011105 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243243011106 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243243011107 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 243243011108 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 243243011109 G1 box; other site 243243011110 GTP/Mg2+ binding site [chemical binding]; other site 243243011111 G2 box; other site 243243011112 Switch I region; other site 243243011113 G3 box; other site 243243011114 Switch II region; other site 243243011115 G4 box; other site 243243011116 G5 box; other site 243243011117 Protein of unknown function (DUF742); Region: DUF742; pfam05331 243243011118 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 243243011119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243243011120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243011121 ATP binding site [chemical binding]; other site 243243011122 Mg2+ binding site [ion binding]; other site 243243011123 G-X-G motif; other site 243243011124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243011125 S-adenosylmethionine binding site [chemical binding]; other site 243243011126 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 243243011127 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 243243011128 FMN binding site [chemical binding]; other site 243243011129 dimer interface [polypeptide binding]; other site 243243011130 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 243243011131 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 243243011132 active site 243243011133 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243243011134 generic binding surface II; other site 243243011135 generic binding surface I; other site 243243011136 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243011137 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243011138 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 243243011139 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 243243011140 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243011141 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 243243011142 dimer interaction site [polypeptide binding]; other site 243243011143 substrate-binding tunnel; other site 243243011144 active site 243243011145 catalytic site [active] 243243011146 substrate binding site [chemical binding]; other site 243243011147 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243011148 catalytic core [active] 243243011149 short chain dehydrogenase; Provisional; Region: PRK07201 243243011150 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 243243011151 putative NAD(P) binding site [chemical binding]; other site 243243011152 active site 243243011153 putative substrate binding site [chemical binding]; other site 243243011154 classical (c) SDRs; Region: SDR_c; cd05233 243243011155 NAD(P) binding site [chemical binding]; other site 243243011156 active site 243243011157 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 243243011158 active site 243243011159 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 243243011160 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243243011161 dimer interface [polypeptide binding]; other site 243243011162 active site 243243011163 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 243243011164 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 243243011165 putative active site [active] 243243011166 putative substrate binding site [chemical binding]; other site 243243011167 putative FMN binding site [chemical binding]; other site 243243011168 putative catalytic residues [active] 243243011169 Y-family of DNA polymerases; Region: PolY; cl12025 243243011170 DNA binding site [nucleotide binding] 243243011171 GMP synthase; Reviewed; Region: guaA; PRK00074 243243011172 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 243243011173 AMP/PPi binding site [chemical binding]; other site 243243011174 candidate oxyanion hole; other site 243243011175 catalytic triad [active] 243243011176 potential glutamine specificity residues [chemical binding]; other site 243243011177 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 243243011178 ATP Binding subdomain [chemical binding]; other site 243243011179 Ligand Binding sites [chemical binding]; other site 243243011180 Dimerization subdomain; other site 243243011181 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243011182 PPE family; Region: PPE; pfam00823 243243011183 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 243243011184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243011185 motif II; other site 243243011186 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 243243011187 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 243243011188 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 243243011189 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 243243011190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243011191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243011192 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 243243011193 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 243243011194 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243243011195 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 243243011196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243011197 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243243011198 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 243243011199 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243243011200 phosphate binding site [ion binding]; other site 243243011201 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 243243011202 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243243011203 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 243243011204 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243243011205 phosphate binding site [ion binding]; other site 243243011206 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 243243011207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243011208 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 243243011209 DNA binding residues [nucleotide binding] 243243011210 Transcription factor WhiB; Region: Whib; pfam02467 243243011211 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 243243011212 E-class dimer interface [polypeptide binding]; other site 243243011213 P-class dimer interface [polypeptide binding]; other site 243243011214 active site 243243011215 Cu2+ binding site [ion binding]; other site 243243011216 Zn2+ binding site [ion binding]; other site 243243011217 hypothetical protein; Provisional; Region: PRK06185 243243011218 hypothetical protein; Provisional; Region: PRK07236 243243011219 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 243243011220 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243243011221 ring oligomerisation interface [polypeptide binding]; other site 243243011222 ATP/Mg binding site [chemical binding]; other site 243243011223 stacking interactions; other site 243243011224 hinge regions; other site 243243011225 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243243011226 oligomerisation interface [polypeptide binding]; other site 243243011227 mobile loop; other site 243243011228 roof hairpin; other site 243243011229 UGMP family protein; Validated; Region: PRK09604 243243011230 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 243243011231 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 243243011232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243011233 Coenzyme A binding pocket [chemical binding]; other site 243243011234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243243011235 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 243243011236 Glycoprotease family; Region: Peptidase_M22; pfam00814 243243011237 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 243243011238 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243011239 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243011240 alanine racemase; Reviewed; Region: alr; PRK00053 243243011241 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 243243011242 active site 243243011243 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243243011244 dimer interface [polypeptide binding]; other site 243243011245 substrate binding site [chemical binding]; other site 243243011246 catalytic residues [active] 243243011247 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 243243011248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243011249 catalytic residue [active] 243243011250 Uncharacterized conserved protein [Function unknown]; Region: COG0062 243243011251 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 243243011252 putative substrate binding site [chemical binding]; other site 243243011253 putative ATP binding site [chemical binding]; other site 243243011254 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 243243011255 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 243243011256 glutaminase active site [active] 243243011257 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 243243011258 dimer interface [polypeptide binding]; other site 243243011259 active site 243243011260 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 243243011261 dimer interface [polypeptide binding]; other site 243243011262 active site 243243011263 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 243243011264 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243011265 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 243243011266 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 243243011267 active site 243243011268 substrate binding site [chemical binding]; other site 243243011269 metal binding site [ion binding]; metal-binding site 243243011270 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 243243011271 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 243243011272 23S rRNA interface [nucleotide binding]; other site 243243011273 L3 interface [polypeptide binding]; other site 243243011274 Proteins of 100 residues with WXG; Region: WXG100; cl02005 243243011275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 243243011276 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 243243011277 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 243243011278 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243243011279 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 243243011280 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243243011281 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243243011282 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 243243011283 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 243243011284 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243243011285 active site 243243011286 catalytic residues [active] 243243011287 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 243243011288 Cutinase; Region: Cutinase; pfam01083 243243011289 Cutinase; Region: Cutinase; pfam01083 243243011290 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 243243011291 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 243243011292 active site 243243011293 dimerization interface 3.5A [polypeptide binding]; other site 243243011294 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 243243011295 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 243243011296 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 243243011297 alphaNTD homodimer interface [polypeptide binding]; other site 243243011298 alphaNTD - beta interaction site [polypeptide binding]; other site 243243011299 alphaNTD - beta' interaction site [polypeptide binding]; other site 243243011300 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243243011301 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 243243011302 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 243243011303 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243243011304 RNA binding surface [nucleotide binding]; other site 243243011305 30S ribosomal protein S11; Validated; Region: PRK05309 243243011306 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 243243011307 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 243243011308 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 243243011309 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 243243011310 rRNA binding site [nucleotide binding]; other site 243243011311 predicted 30S ribosome binding site; other site 243243011312 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 243243011313 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 243243011314 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243011315 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 243243011316 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 243243011317 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 243243011318 NAD binding site [chemical binding]; other site 243243011319 substrate binding site [chemical binding]; other site 243243011320 homodimer interface [polypeptide binding]; other site 243243011321 active site 243243011322 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 243243011323 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243011324 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243011325 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243011326 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 243243011327 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243243011328 active site 243243011329 metal binding site [ion binding]; metal-binding site 243243011330 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 243243011331 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 243243011332 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 243243011333 iron-sulfur cluster [ion binding]; other site 243243011334 [2Fe-2S] cluster binding site [ion binding]; other site 243243011335 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 243243011336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243011337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243011338 DNA binding residues [nucleotide binding] 243243011339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243011340 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 243243011341 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 243243011342 tetrameric interface [polypeptide binding]; other site 243243011343 NAD binding site [chemical binding]; other site 243243011344 catalytic residues [active] 243243011345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243011346 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 243243011347 substrate binding pocket [chemical binding]; other site 243243011348 FAD binding site [chemical binding]; other site 243243011349 catalytic base [active] 243243011350 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243243011351 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 243243011352 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243011353 MarR family; Region: MarR; pfam01047 243243011354 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 243243011355 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243011356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243011357 homodimer interface [polypeptide binding]; other site 243243011358 catalytic residue [active] 243243011359 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 243243011360 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243243011361 active site 243243011362 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 243243011363 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243243011364 PYR/PP interface [polypeptide binding]; other site 243243011365 dimer interface [polypeptide binding]; other site 243243011366 TPP binding site [chemical binding]; other site 243243011367 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 243243011368 TPP-binding site [chemical binding]; other site 243243011369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243243011370 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243243011371 Walker A/P-loop; other site 243243011372 ATP binding site [chemical binding]; other site 243243011373 Q-loop/lid; other site 243243011374 ABC transporter signature motif; other site 243243011375 Walker B; other site 243243011376 D-loop; other site 243243011377 H-loop/switch region; other site 243243011378 FtsX-like permease family; Region: FtsX; pfam02687 243243011379 Methyltransferase domain; Region: Methyltransf_11; pfam08241 243243011380 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243011381 Putative zinc-finger; Region: zf-HC2; pfam13490 243243011382 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 243243011383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243011384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243011385 DNA binding residues [nucleotide binding] 243243011386 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243243011387 active site 243243011388 adenylate kinase; Reviewed; Region: adk; PRK00279 243243011389 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243243011390 AMP-binding site [chemical binding]; other site 243243011391 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243243011392 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 243243011393 SecY translocase; Region: SecY; pfam00344 243243011394 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243011395 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243011396 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243243011397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243243011398 Coenzyme A binding pocket [chemical binding]; other site 243243011399 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 243243011400 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243243011401 nucleotide binding site [chemical binding]; other site 243243011402 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 243243011403 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 243243011404 NAD binding site [chemical binding]; other site 243243011405 L-fuculose-phosphate aldolase; Validated; Region: PRK05874 243243011406 intersubunit interface [polypeptide binding]; other site 243243011407 active site 243243011408 Zn2+ binding site [ion binding]; other site 243243011409 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243243011410 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243243011411 NAD(P) binding site [chemical binding]; other site 243243011412 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243011413 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243011414 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243011415 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243011416 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243011417 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243011418 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 243243011419 tandem repeat interface [polypeptide binding]; other site 243243011420 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 243243011421 oligomer interface [polypeptide binding]; other site 243243011422 active site residues [active] 243243011423 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 243243011424 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 243243011425 tandem repeat interface [polypeptide binding]; other site 243243011426 oligomer interface [polypeptide binding]; other site 243243011427 active site residues [active] 243243011428 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243011429 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243011430 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 243243011431 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 243243011432 23S rRNA binding site [nucleotide binding]; other site 243243011433 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 243243011434 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 243243011435 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 243243011436 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 243243011437 5S rRNA interface [nucleotide binding]; other site 243243011438 L27 interface [polypeptide binding]; other site 243243011439 23S rRNA interface [nucleotide binding]; other site 243243011440 L5 interface [polypeptide binding]; other site 243243011441 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 243243011442 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243243011443 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243243011444 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 243243011445 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 243243011446 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 243243011447 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 243243011448 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 243243011449 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 243243011450 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 243243011451 RNA binding site [nucleotide binding]; other site 243243011452 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 243243011453 Domain of unknown function (DUF222); Region: DUF222; pfam02720 243243011454 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243243011455 active site 243243011456 Uncharacterized conserved protein [Function unknown]; Region: COG1262 243243011457 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 243243011458 PBP superfamily domain; Region: PBP_like_2; cl17296 243243011459 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243243011460 Sulfatase; Region: Sulfatase; pfam00884 243243011461 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 243243011462 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 243243011463 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 243243011464 putative translocon interaction site; other site 243243011465 signal recognition particle (SRP54) interaction site; other site 243243011466 L23 interface [polypeptide binding]; other site 243243011467 trigger factor interaction site; other site 243243011468 23S rRNA interface [nucleotide binding]; other site 243243011469 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 243243011470 23S rRNA interface [nucleotide binding]; other site 243243011471 5S rRNA interface [nucleotide binding]; other site 243243011472 putative antibiotic binding site [chemical binding]; other site 243243011473 L25 interface [polypeptide binding]; other site 243243011474 L27 interface [polypeptide binding]; other site 243243011475 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 243243011476 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 243243011477 G-X-X-G motif; other site 243243011478 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 243243011479 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 243243011480 putative translocon binding site; other site 243243011481 protein-rRNA interface [nucleotide binding]; other site 243243011482 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 243243011483 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 243243011484 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 243243011485 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 243243011486 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 243243011487 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 243243011488 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 243243011489 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 243243011490 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 243243011491 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243243011492 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 243243011493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243243011494 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 243243011495 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 243243011496 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243243011497 phosphate binding site [ion binding]; other site 243243011498 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 243243011499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243243011500 FeS/SAM binding site; other site 243243011501 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243243011502 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 243243011503 mycofactocin precursor; Region: mycofactocin; TIGR03969 243243011504 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243011505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243011506 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 243243011507 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243011508 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243011509 active site 243243011510 catalytic tetrad [active] 243243011511 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 243243011512 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243243011513 active site 243243011514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243243011515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243011516 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243011517 classical (c) SDRs; Region: SDR_c; cd05233 243243011518 NAD(P) binding site [chemical binding]; other site 243243011519 active site 243243011520 Short C-terminal domain; Region: SHOCT; pfam09851 243243011521 elongation factor Tu; Reviewed; Region: PRK00049 243243011522 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243243011523 G1 box; other site 243243011524 GEF interaction site [polypeptide binding]; other site 243243011525 GTP/Mg2+ binding site [chemical binding]; other site 243243011526 Switch I region; other site 243243011527 G2 box; other site 243243011528 G3 box; other site 243243011529 Switch II region; other site 243243011530 G4 box; other site 243243011531 G5 box; other site 243243011532 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 243243011533 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243243011534 Antibiotic Binding Site [chemical binding]; other site 243243011535 elongation factor G; Reviewed; Region: PRK00007 243243011536 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243243011537 G1 box; other site 243243011538 putative GEF interaction site [polypeptide binding]; other site 243243011539 GTP/Mg2+ binding site [chemical binding]; other site 243243011540 Switch I region; other site 243243011541 G2 box; other site 243243011542 G3 box; other site 243243011543 Switch II region; other site 243243011544 G4 box; other site 243243011545 G5 box; other site 243243011546 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243243011547 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243243011548 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243243011549 30S ribosomal protein S7; Validated; Region: PRK05302 243243011550 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 243243011551 S17 interaction site [polypeptide binding]; other site 243243011552 S8 interaction site; other site 243243011553 16S rRNA interaction site [nucleotide binding]; other site 243243011554 streptomycin interaction site [chemical binding]; other site 243243011555 23S rRNA interaction site [nucleotide binding]; other site 243243011556 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 243243011557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243011558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243011559 WHG domain; Region: WHG; pfam13305 243243011560 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 243243011561 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 243243011562 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243011563 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243011564 substrate binding site [chemical binding]; other site 243243011565 oxyanion hole (OAH) forming residues; other site 243243011566 trimer interface [polypeptide binding]; other site 243243011567 PaaX-like protein; Region: PaaX; pfam07848 243243011568 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 243243011569 enoyl-CoA hydratase; Provisional; Region: PRK12478 243243011570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243011571 substrate binding site [chemical binding]; other site 243243011572 oxyanion hole (OAH) forming residues; other site 243243011573 trimer interface [polypeptide binding]; other site 243243011574 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 243243011575 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243011576 active site 243243011577 endonuclease IV; Provisional; Region: PRK01060 243243011578 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 243243011579 AP (apurinic/apyrimidinic) site pocket; other site 243243011580 DNA interaction; other site 243243011581 Metal-binding active site; metal-binding site 243243011582 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 243243011583 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 243243011584 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 243243011585 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 243243011586 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 243243011587 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 243243011588 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 243243011589 G-loop; other site 243243011590 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 243243011591 DNA binding site [nucleotide binding] 243243011592 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 243243011593 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 243243011594 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 243243011595 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 243243011596 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243243011597 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243243011598 RPB10 interaction site [polypeptide binding]; other site 243243011599 RPB1 interaction site [polypeptide binding]; other site 243243011600 RPB11 interaction site [polypeptide binding]; other site 243243011601 RPB3 interaction site [polypeptide binding]; other site 243243011602 RPB12 interaction site [polypeptide binding]; other site 243243011603 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243243011604 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243243011605 Walker A/P-loop; other site 243243011606 ATP binding site [chemical binding]; other site 243243011607 Q-loop/lid; other site 243243011608 ABC transporter signature motif; other site 243243011609 Walker B; other site 243243011610 D-loop; other site 243243011611 H-loop/switch region; other site 243243011612 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 243243011613 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 243243011614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243011615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243011616 WHG domain; Region: WHG; pfam13305 243243011617 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 243243011618 core dimer interface [polypeptide binding]; other site 243243011619 peripheral dimer interface [polypeptide binding]; other site 243243011620 L10 interface [polypeptide binding]; other site 243243011621 L11 interface [polypeptide binding]; other site 243243011622 putative EF-Tu interaction site [polypeptide binding]; other site 243243011623 putative EF-G interaction site [polypeptide binding]; other site 243243011624 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 243243011625 23S rRNA interface [nucleotide binding]; other site 243243011626 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 243243011627 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 243243011628 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243243011629 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243243011630 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 243243011631 active site 243243011632 catalytic site [active] 243243011633 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 243243011634 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 243243011635 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 243243011636 Protein of unknown function (DUF664); Region: DUF664; pfam04978 243243011637 DinB superfamily; Region: DinB_2; pfam12867 243243011638 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 243243011639 ABC1 family; Region: ABC1; pfam03109 243243011640 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 243243011641 active site 243243011642 ATP binding site [chemical binding]; other site 243243011643 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 243243011644 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 243243011645 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243243011646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243011647 S-adenosylmethionine binding site [chemical binding]; other site 243243011648 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243243011649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243011650 S-adenosylmethionine binding site [chemical binding]; other site 243243011651 YCII-related domain; Region: YCII; cl00999 243243011652 YCII-related domain; Region: YCII; cl00999 243243011653 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 243243011654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243011655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243011656 DNA binding residues [nucleotide binding] 243243011657 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 243243011658 mRNA/rRNA interface [nucleotide binding]; other site 243243011659 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 243243011660 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 243243011661 23S rRNA interface [nucleotide binding]; other site 243243011662 L7/L12 interface [polypeptide binding]; other site 243243011663 putative thiostrepton binding site; other site 243243011664 L25 interface [polypeptide binding]; other site 243243011665 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 243243011666 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 243243011667 putative homodimer interface [polypeptide binding]; other site 243243011668 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 243243011669 heterodimer interface [polypeptide binding]; other site 243243011670 homodimer interface [polypeptide binding]; other site 243243011671 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 243243011672 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 243243011673 active site 243243011674 catalytic site [active] 243243011675 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 243243011676 active site 243243011677 catalytic site [active] 243243011678 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 243243011679 active site 243243011680 catalytic site [active] 243243011681 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 243243011682 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 243243011683 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243243011684 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243011685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243011686 substrate binding site [chemical binding]; other site 243243011687 oxyanion hole (OAH) forming residues; other site 243243011688 trimer interface [polypeptide binding]; other site 243243011689 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 243243011690 [4Fe-4S] binding site [ion binding]; other site 243243011691 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 243243011692 molybdopterin cofactor binding site; other site 243243011693 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 243243011694 molybdopterin cofactor binding site; other site 243243011695 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243243011696 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 243243011697 active site 243243011698 nucleophile elbow; other site 243243011699 cyanate hydratase; Validated; Region: PRK02866 243243011700 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 243243011701 oligomer interface [polypeptide binding]; other site 243243011702 active site 243243011703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243011704 S-adenosylmethionine binding site [chemical binding]; other site 243243011705 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 243243011706 putative FMN binding site [chemical binding]; other site 243243011707 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243243011708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243011709 S-adenosylmethionine binding site [chemical binding]; other site 243243011710 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 243243011711 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 243243011712 Part of AAA domain; Region: AAA_19; pfam13245 243243011713 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 243243011714 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 243243011715 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 243243011716 AAA domain; Region: AAA_30; pfam13604 243243011717 Family description; Region: UvrD_C_2; pfam13538 243243011718 Uncharacterized conserved protein [Function unknown]; Region: COG0398 243243011719 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 243243011720 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243011721 mce related protein; Region: MCE; pfam02470 243243011722 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243011723 mce related protein; Region: MCE; pfam02470 243243011724 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243011725 mce related protein; Region: MCE; pfam02470 243243011726 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243011727 mce related protein; Region: MCE; pfam02470 243243011728 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243243011729 mce related protein; Region: MCE; pfam02470 243243011730 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243011731 mce related protein; Region: MCE; pfam02470 243243011732 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243011733 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243011734 Permease; Region: Permease; pfam02405 243243011735 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243011736 Permease; Region: Permease; pfam02405 243243011737 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 243243011738 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243011739 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243011740 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243011741 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243011742 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243011743 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 243243011744 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 243243011745 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 243243011746 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 243243011747 PAS fold; Region: PAS_3; pfam08447 243243011748 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 243243011749 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 243243011750 Uncharacterized conserved protein [Function unknown]; Region: COG1656 243243011751 Protein of unknown function DUF82; Region: DUF82; pfam01927 243243011752 galactokinase; Provisional; Region: PRK00555 243243011753 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 243243011754 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243243011755 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 243243011756 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 243243011757 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 243243011758 dimer interface [polypeptide binding]; other site 243243011759 active site 243243011760 Predicted membrane protein [Function unknown]; Region: COG1289 243243011761 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 243243011762 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243011763 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243011764 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 243243011765 putative hydrolase; Provisional; Region: PRK11460 243243011766 Uncharacterized conserved protein [Function unknown]; Region: COG1432 243243011767 NYN domain; Region: NYN; pfam01936 243243011768 putative metal binding site [ion binding]; other site 243243011769 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 243243011770 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243011771 Cytochrome P450; Region: p450; cl12078 243243011772 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 243243011773 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243243011774 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243011775 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243011776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 243243011777 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 243243011778 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243011779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243011780 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 243243011781 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 243243011782 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 243243011783 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 243243011784 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243243011785 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243243011786 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243243011787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243011788 salt bridge; other site 243243011789 non-specific DNA binding site [nucleotide binding]; other site 243243011790 sequence-specific DNA binding site [nucleotide binding]; other site 243243011791 heat shock protein HtpX; Provisional; Region: PRK03072 243243011792 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243243011793 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243243011794 substrate binding pocket [chemical binding]; other site 243243011795 chain length determination region; other site 243243011796 substrate-Mg2+ binding site; other site 243243011797 catalytic residues [active] 243243011798 aspartate-rich region 1; other site 243243011799 active site lid residues [active] 243243011800 aspartate-rich region 2; other site 243243011801 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 243243011802 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243243011803 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243011804 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 243243011805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243011806 S-adenosylmethionine binding site [chemical binding]; other site 243243011807 short chain dehydrogenase; Provisional; Region: PRK08263 243243011808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243011809 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 243243011810 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 243243011811 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 243243011812 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 243243011813 dimer interface [polypeptide binding]; other site 243243011814 tetramer interface [polypeptide binding]; other site 243243011815 PYR/PP interface [polypeptide binding]; other site 243243011816 TPP binding site [chemical binding]; other site 243243011817 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 243243011818 TPP-binding site; other site 243243011819 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 243243011820 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243011821 TAP-like protein; Region: Abhydrolase_4; pfam08386 243243011822 O-succinylbenzoate synthase; Provisional; Region: PRK02901 243243011823 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 243243011824 active site 243243011825 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 243243011826 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 243243011827 active site 243243011828 acyl-CoA synthetase; Validated; Region: PRK06188 243243011829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243011830 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243011831 acyl-activating enzyme (AAE) consensus motif; other site 243243011832 acyl-activating enzyme (AAE) consensus motif; other site 243243011833 putative AMP binding site [chemical binding]; other site 243243011834 putative active site [active] 243243011835 putative CoA binding site [chemical binding]; other site 243243011836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243011837 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243243011838 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243243011839 active site 243243011840 catalytic tetrad [active] 243243011841 Domain of unknown function (DUF385); Region: DUF385; cl04387 243243011842 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243011843 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 243243011844 substrate binding site [chemical binding]; other site 243243011845 oxyanion hole (OAH) forming residues; other site 243243011846 trimer interface [polypeptide binding]; other site 243243011847 short chain dehydrogenase; Provisional; Region: PRK05866 243243011848 classical (c) SDRs; Region: SDR_c; cd05233 243243011849 NAD(P) binding site [chemical binding]; other site 243243011850 active site 243243011851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243011852 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243243011853 active site 243243011854 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 243243011855 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 243243011856 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 243243011857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243011858 acyl-activating enzyme (AAE) consensus motif; other site 243243011859 AMP binding site [chemical binding]; other site 243243011860 active site 243243011861 CoA binding site [chemical binding]; other site 243243011862 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 243243011863 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 243243011864 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243243011865 Ligand binding site; other site 243243011866 Putative Catalytic site; other site 243243011867 DXD motif; other site 243243011868 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243011869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243011870 NAD(P) binding site [chemical binding]; other site 243243011871 active site 243243011872 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 243243011873 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 243243011874 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243243011875 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243243011876 dimer interface [polypeptide binding]; other site 243243011877 active site 243243011878 CoA binding pocket [chemical binding]; other site 243243011879 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 243243011880 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243243011881 P-loop; other site 243243011882 Magnesium ion binding site [ion binding]; other site 243243011883 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 243243011884 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 243243011885 ResB-like family; Region: ResB; pfam05140 243243011886 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 243243011887 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 243243011888 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243243011889 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243243011890 catalytic residues [active] 243243011891 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243011892 catalytic core [active] 243243011893 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243243011894 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 243243011895 inhibitor-cofactor binding pocket; inhibition site 243243011896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243011897 catalytic residue [active] 243243011898 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 243243011899 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 243243011900 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 243243011901 metal binding site [ion binding]; metal-binding site 243243011902 substrate binding pocket [chemical binding]; other site 243243011903 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 243243011904 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243243011905 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243243011906 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 243243011907 metabolite-proton symporter; Region: 2A0106; TIGR00883 243243011908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243011909 putative substrate translocation pore; other site 243243011910 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 243243011911 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 243243011912 active site 243243011913 dimer interface [polypeptide binding]; other site 243243011914 non-prolyl cis peptide bond; other site 243243011915 insertion regions; other site 243243011916 Predicted esterase [General function prediction only]; Region: COG0627 243243011917 S-formylglutathione hydrolase; Region: PLN02442 243243011918 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243011919 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243243011920 active site 243243011921 catalytic triad [active] 243243011922 oxyanion hole [active] 243243011923 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243011924 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243011925 anti sigma factor interaction site; other site 243243011926 regulatory phosphorylation site [posttranslational modification]; other site 243243011927 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 243243011928 dimer interface [polypeptide binding]; other site 243243011929 active site 243243011930 Schiff base residues; other site 243243011931 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 243243011932 active site 243243011933 homodimer interface [polypeptide binding]; other site 243243011934 SAM binding site [chemical binding]; other site 243243011935 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 243243011936 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 243243011937 active site 243243011938 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 243243011939 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 243243011940 domain interfaces; other site 243243011941 active site 243243011942 glutamyl-tRNA reductase; Region: hemA; TIGR01035 243243011943 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 243243011944 tRNA; other site 243243011945 putative tRNA binding site [nucleotide binding]; other site 243243011946 putative NADP binding site [chemical binding]; other site 243243011947 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 243243011948 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 243243011949 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 243243011950 Proteins of 100 residues with WXG; Region: WXG100; cl02005 243243011951 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 243243011952 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 243243011953 active site 243243011954 conformational flexibility of ligand binding pocket; other site 243243011955 ADP-ribosylating toxin turn-turn motif; other site 243243011956 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 243243011957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243011958 motif II; other site 243243011959 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 243243011960 active site 243243011961 catalytic site [active] 243243011962 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243243011963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243243011964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243011965 S-adenosylmethionine binding site [chemical binding]; other site 243243011966 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243243011967 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 243243011968 putative acyl-acceptor binding pocket; other site 243243011969 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243243011970 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 243243011971 putative NAD(P) binding site [chemical binding]; other site 243243011972 active site 243243011973 putative substrate binding site [chemical binding]; other site 243243011974 Helix-turn-helix domain; Region: HTH_17; cl17695 243243011975 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 243243011976 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 243243011977 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 243243011978 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 243243011979 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243243011980 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 243243011981 DNA interaction; other site 243243011982 exopolyphosphatase; Region: exo_poly_only; TIGR03706 243243011983 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 243243011984 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 243243011985 nudix motif; other site 243243011986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243243011987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243011988 active site 243243011989 phosphorylation site [posttranslational modification] 243243011990 intermolecular recognition site; other site 243243011991 dimerization interface [polypeptide binding]; other site 243243011992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243243011993 DNA binding site [nucleotide binding] 243243011994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243243011995 dimer interface [polypeptide binding]; other site 243243011996 phosphorylation site [posttranslational modification] 243243011997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243243011998 ATP binding site [chemical binding]; other site 243243011999 Mg2+ binding site [ion binding]; other site 243243012000 G-X-G motif; other site 243243012001 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243012002 catalytic core [active] 243243012003 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243012004 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 243243012005 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 243243012006 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 243243012007 putative ADP-binding pocket [chemical binding]; other site 243243012008 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243243012009 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243243012010 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 243243012011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243012012 NAD(P) binding site [chemical binding]; other site 243243012013 active site 243243012014 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 243243012015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243243012016 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 243243012017 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243243012018 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 243243012019 FAD binding domain; Region: FAD_binding_4; pfam01565 243243012020 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 243243012021 Predicted amidohydrolase [General function prediction only]; Region: COG0388 243243012022 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 243243012023 putative active site [active] 243243012024 catalytic triad [active] 243243012025 putative dimer interface [polypeptide binding]; other site 243243012026 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 243243012027 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 243243012028 catalytic residue [active] 243243012029 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 243243012030 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 243243012031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243012032 non-specific DNA binding site [nucleotide binding]; other site 243243012033 salt bridge; other site 243243012034 sequence-specific DNA binding site [nucleotide binding]; other site 243243012035 Predicted membrane protein [Function unknown]; Region: COG2733 243243012036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012038 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243243012039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243012040 S-adenosylmethionine binding site [chemical binding]; other site 243243012041 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 243243012042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243012043 S-adenosylmethionine binding site [chemical binding]; other site 243243012044 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 243243012045 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 243243012046 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 243243012047 isocitrate lyase; Provisional; Region: PRK15063 243243012048 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 243243012049 tetramer interface [polypeptide binding]; other site 243243012050 active site 243243012051 Mg2+/Mn2+ binding site [ion binding]; other site 243243012052 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 243243012053 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243243012054 active site 243243012055 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243012056 active site 2 [active] 243243012057 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243243012058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243243012059 non-specific DNA binding site [nucleotide binding]; other site 243243012060 salt bridge; other site 243243012061 sequence-specific DNA binding site [nucleotide binding]; other site 243243012062 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 243243012063 Domain of unknown function (DUF955); Region: DUF955; pfam06114 243243012064 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 243243012065 Uncharacterized conserved protein [Function unknown]; Region: COG2128 243243012066 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 243243012067 Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...; Region: Calpain_III; cl00165 243243012068 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 243243012069 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 243243012070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243012071 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243243012072 Protein of unknown function (DUF779); Region: DUF779; cl01432 243243012073 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 243243012074 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243012075 NAD(P) binding site [chemical binding]; other site 243243012076 catalytic residues [active] 243243012077 enoyl-CoA hydratase; Provisional; Region: PRK12478 243243012078 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243012079 substrate binding site [chemical binding]; other site 243243012080 oxyanion hole (OAH) forming residues; other site 243243012081 trimer interface [polypeptide binding]; other site 243243012082 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 243243012083 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 243243012084 Tetrahydromethanopterin S-methyltransferase subunit B; Region: MtrB; cl01678 243243012085 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243012086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012088 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 243243012089 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 243243012090 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 243243012091 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243243012092 catalytic residues [active] 243243012093 Protein of unknown function (DUF664); Region: DUF664; pfam04978 243243012094 DinB superfamily; Region: DinB_2; pfam12867 243243012095 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 243243012096 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243012097 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 243243012098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243012099 active site 243243012100 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243012101 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243012102 PPE family; Region: PPE; pfam00823 243243012103 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 243243012104 putative active site [active] 243243012105 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 243243012106 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243243012107 ring oligomerisation interface [polypeptide binding]; other site 243243012108 ATP/Mg binding site [chemical binding]; other site 243243012109 stacking interactions; other site 243243012110 hinge regions; other site 243243012111 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 243243012112 active site 243243012113 Cupin domain; Region: Cupin_2; pfam07883 243243012114 short chain dehydrogenase; Provisional; Region: PRK06197 243243012115 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 243243012116 putative NAD(P) binding site [chemical binding]; other site 243243012117 active site 243243012118 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 243243012119 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 243243012120 dimer interface [polypeptide binding]; other site 243243012121 putative functional site; other site 243243012122 putative MPT binding site; other site 243243012123 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 243243012124 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 243243012125 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 243243012126 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 243243012127 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 243243012128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243012129 Walker A motif; other site 243243012130 ATP binding site [chemical binding]; other site 243243012131 Walker B motif; other site 243243012132 arginine finger; other site 243243012133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243012134 Walker A motif; other site 243243012135 ATP binding site [chemical binding]; other site 243243012136 Walker B motif; other site 243243012137 arginine finger; other site 243243012138 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 243243012139 enoyl-CoA hydratase; Provisional; Region: PRK08260 243243012140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243012141 substrate binding site [chemical binding]; other site 243243012142 oxyanion hole (OAH) forming residues; other site 243243012143 trimer interface [polypeptide binding]; other site 243243012144 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 243243012145 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243012146 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 243243012147 carboxylate-amine ligase; Provisional; Region: PRK13517 243243012148 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 243243012149 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 243243012150 E-class dimer interface [polypeptide binding]; other site 243243012151 P-class dimer interface [polypeptide binding]; other site 243243012152 active site 243243012153 Cu2+ binding site [ion binding]; other site 243243012154 Zn2+ binding site [ion binding]; other site 243243012155 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 243243012156 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 243243012157 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243243012158 active site 243243012159 catalytic residues [active] 243243012160 metal binding site [ion binding]; metal-binding site 243243012161 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 243243012162 putative catalytic site [active] 243243012163 putative phosphate binding site [ion binding]; other site 243243012164 active site 243243012165 metal binding site A [ion binding]; metal-binding site 243243012166 DNA binding site [nucleotide binding] 243243012167 putative AP binding site [nucleotide binding]; other site 243243012168 putative metal binding site B [ion binding]; other site 243243012169 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 243243012170 ThiC-associated domain; Region: ThiC-associated; pfam13667 243243012171 ThiC family; Region: ThiC; pfam01964 243243012172 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 243243012173 dimer interface [polypeptide binding]; other site 243243012174 substrate binding site [chemical binding]; other site 243243012175 ATP binding site [chemical binding]; other site 243243012176 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243243012177 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243012178 MarR family; Region: MarR; pfam01047 243243012179 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 243243012180 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243012181 Predicted metalloprotease [General function prediction only]; Region: COG2321 243243012182 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 243243012183 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 243243012184 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 243243012185 PA/protease or protease-like domain interface [polypeptide binding]; other site 243243012186 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 243243012187 Peptidase family M28; Region: Peptidase_M28; pfam04389 243243012188 active site 243243012189 metal binding site [ion binding]; metal-binding site 243243012190 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 243243012191 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 243243012192 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 243243012193 PA/protease or protease-like domain interface [polypeptide binding]; other site 243243012194 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 243243012195 active site 243243012196 metal binding site [ion binding]; metal-binding site 243243012197 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 243243012198 Interferon-induced transmembrane protein; Region: CD225; pfam04505 243243012199 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 243243012200 active site 243243012201 catalytic triad [active] 243243012202 oxyanion hole [active] 243243012203 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 243243012204 ThiS interaction site; other site 243243012205 putative active site [active] 243243012206 tetramer interface [polypeptide binding]; other site 243243012207 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 243243012208 thiS-thiF/thiG interaction site; other site 243243012209 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 243243012210 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243243012211 active site 243243012212 thiamine phosphate binding site [chemical binding]; other site 243243012213 pyrophosphate binding site [ion binding]; other site 243243012214 NUDIX domain; Region: NUDIX; pfam00293 243243012215 nudix motif; other site 243243012216 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243243012217 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243243012218 substrate binding pocket [chemical binding]; other site 243243012219 membrane-bound complex binding site; other site 243243012220 hinge residues; other site 243243012221 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 243243012222 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243243012223 active site 243243012224 ATP binding site [chemical binding]; other site 243243012225 substrate binding site [chemical binding]; other site 243243012226 activation loop (A-loop); other site 243243012227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012229 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 243243012230 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 243243012231 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 243243012232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 243243012233 propionate/acetate kinase; Provisional; Region: PRK12379 243243012234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243243012235 nucleotide binding site [chemical binding]; other site 243243012236 Butyrate kinase [Energy production and conversion]; Region: COG3426 243243012237 phosphate acetyltransferase; Reviewed; Region: PRK05632 243243012238 DRTGG domain; Region: DRTGG; pfam07085 243243012239 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 243243012240 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 243243012241 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 243243012242 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243012243 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243243012244 Leucine carboxyl methyltransferase; Region: LCM; cl01306 243243012245 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243012246 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 243243012247 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 243243012248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243012249 NAD(P) binding site [chemical binding]; other site 243243012250 active site 243243012251 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243012252 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243012253 active site 243243012254 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243012255 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243012256 active site 243243012257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012259 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243243012260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243012261 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 243243012262 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243243012263 homodimer interface [polypeptide binding]; other site 243243012264 substrate-cofactor binding pocket; other site 243243012265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243012266 catalytic residue [active] 243243012267 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 243243012268 active site residue [active] 243243012269 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 243243012270 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243243012271 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243243012272 CoenzymeA binding site [chemical binding]; other site 243243012273 subunit interaction site [polypeptide binding]; other site 243243012274 PHB binding site; other site 243243012275 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 243243012276 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 243243012277 GDP-binding site [chemical binding]; other site 243243012278 ACT binding site; other site 243243012279 IMP binding site; other site 243243012280 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243243012281 catalytic core [active] 243243012282 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 243243012283 Peptidase family M50; Region: Peptidase_M50; pfam02163 243243012284 active site 243243012285 putative substrate binding region [chemical binding]; other site 243243012286 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 243243012287 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 243243012288 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243243012289 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 243243012290 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 243243012291 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 243243012292 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 243243012293 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 243243012294 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 243243012295 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243243012296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243243012297 active site 243243012298 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243243012299 classical (c) SDRs; Region: SDR_c; cd05233 243243012300 NAD(P) binding site [chemical binding]; other site 243243012301 active site 243243012302 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 243243012303 Clp amino terminal domain; Region: Clp_N; pfam02861 243243012304 Clp amino terminal domain; Region: Clp_N; pfam02861 243243012305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243012306 Walker A motif; other site 243243012307 ATP binding site [chemical binding]; other site 243243012308 Walker B motif; other site 243243012309 arginine finger; other site 243243012310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243012311 Walker A motif; other site 243243012312 ATP binding site [chemical binding]; other site 243243012313 Walker B motif; other site 243243012314 arginine finger; other site 243243012315 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243243012316 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 243243012317 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 243243012318 heme-binding site [chemical binding]; other site 243243012319 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 243243012320 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 243243012321 FAD binding pocket [chemical binding]; other site 243243012322 FAD binding motif [chemical binding]; other site 243243012323 phosphate binding motif [ion binding]; other site 243243012324 beta-alpha-beta structure motif; other site 243243012325 NAD binding pocket [chemical binding]; other site 243243012326 Uncharacterized conserved protein [Function unknown]; Region: COG3349 243243012327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243012328 SCP-2 sterol transfer family; Region: SCP2; cl01225 243243012329 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 243243012330 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243243012331 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243243012332 substrate binding pocket [chemical binding]; other site 243243012333 chain length determination region; other site 243243012334 substrate-Mg2+ binding site; other site 243243012335 catalytic residues [active] 243243012336 aspartate-rich region 1; other site 243243012337 active site lid residues [active] 243243012338 aspartate-rich region 2; other site 243243012339 AAA ATPase domain; Region: AAA_16; pfam13191 243243012340 Predicted ATPase [General function prediction only]; Region: COG3899 243243012341 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243243012342 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243243012343 cyclase homology domain; Region: CHD; cd07302 243243012344 nucleotidyl binding site; other site 243243012345 metal binding site [ion binding]; metal-binding site 243243012346 dimer interface [polypeptide binding]; other site 243243012347 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 243243012348 DNA binding residues [nucleotide binding] 243243012349 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 243243012350 putative dimer interface [polypeptide binding]; other site 243243012351 chaperone protein DnaJ; Provisional; Region: PRK14279 243243012352 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243243012353 HSP70 interaction site [polypeptide binding]; other site 243243012354 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 243243012355 Zn binding sites [ion binding]; other site 243243012356 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243243012357 dimer interface [polypeptide binding]; other site 243243012358 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 243243012359 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 243243012360 dimer interface [polypeptide binding]; other site 243243012361 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 243243012362 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 243243012363 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 243243012364 nucleotide binding site [chemical binding]; other site 243243012365 NEF interaction site [polypeptide binding]; other site 243243012366 SBD interface [polypeptide binding]; other site 243243012367 RES domain; Region: RES; smart00953 243243012368 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 243243012369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243012370 putative substrate translocation pore; other site 243243012371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243012372 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243243012373 nucleotide binding site [chemical binding]; other site 243243012374 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243243012375 4Fe-4S binding domain; Region: Fer4; pfam00037 243243012376 Cysteine-rich domain; Region: CCG; pfam02754 243243012377 Cysteine-rich domain; Region: CCG; pfam02754 243243012378 aminotransferase AlaT; Validated; Region: PRK09265 243243012379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243243012380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243243012381 homodimer interface [polypeptide binding]; other site 243243012382 catalytic residue [active] 243243012383 YibE/F-like protein; Region: YibE_F; pfam07907 243243012384 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 243243012385 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 243243012386 substrate binding site; other site 243243012387 tetramer interface; other site 243243012388 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243012389 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 243243012390 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 243243012391 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 243243012392 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243243012393 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 243243012394 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243243012395 trimer interface [polypeptide binding]; other site 243243012396 active site 243243012397 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 243243012398 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 243243012399 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 243243012400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243243012401 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243243012402 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243012403 Protein of unknown function (DUF732); Region: DUF732; pfam05305 243243012404 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 243243012405 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 243243012406 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 243243012407 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 243243012408 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 243243012409 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243243012410 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 243243012411 active site 243243012412 catalytic residues [active] 243243012413 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 243243012414 Prostaglandin dehydrogenases; Region: PGDH; cd05288 243243012415 NAD(P) binding site [chemical binding]; other site 243243012416 substrate binding site [chemical binding]; other site 243243012417 dimer interface [polypeptide binding]; other site 243243012418 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 243243012419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012421 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 243243012422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 243243012423 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 243243012424 active site 243243012425 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243243012426 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 243243012427 putative FMN binding site [chemical binding]; other site 243243012428 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 243243012429 Sulfatase; Region: Sulfatase; pfam00884 243243012430 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 243243012431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243012432 S-adenosylmethionine binding site [chemical binding]; other site 243243012433 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243012434 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 243243012435 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 243243012436 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243243012437 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 243243012438 catalytic residues [active] 243243012439 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243243012440 catalytic residues [active] 243243012441 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 243243012442 EspG family; Region: ESX-1_EspG; pfam14011 243243012443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 243243012444 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243012445 PPE family; Region: PPE; pfam00823 243243012446 Protein of unknown function (DUF690); Region: DUF690; pfam05108 243243012447 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 243243012448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243243012449 Walker A motif; other site 243243012450 ATP binding site [chemical binding]; other site 243243012451 Walker B motif; other site 243243012452 arginine finger; other site 243243012453 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243012454 PPE family; Region: PPE; pfam00823 243243012455 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243012456 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243012457 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243012458 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243243012459 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 243243012460 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 243243012461 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 243243012462 TIGR03943 family protein; Region: TIGR03943 243243012463 Predicted permease; Region: DUF318; cl17795 243243012464 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 243243012465 PPE family; Region: PPE; pfam00823 243243012466 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 243243012467 Condensation domain; Region: Condensation; pfam00668 243243012468 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 243243012469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243012470 Zn binding site [ion binding]; other site 243243012471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243012474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243012475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243012476 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 243243012477 FAD binding site [chemical binding]; other site 243243012478 substrate binding site [chemical binding]; other site 243243012479 catalytic base [active] 243243012480 acyl-CoA synthetase; Validated; Region: PRK07788 243243012481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243012482 acyl-activating enzyme (AAE) consensus motif; other site 243243012483 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243012484 active site 243243012485 CoA binding site [chemical binding]; other site 243243012486 AMP binding site [chemical binding]; other site 243243012487 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 243243012488 nucleotide binding site [chemical binding]; other site 243243012489 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 243243012490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243012491 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 243243012492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012493 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 243243012494 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 243243012495 intersubunit interface [polypeptide binding]; other site 243243012496 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 243243012497 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 243243012498 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 243243012499 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 243243012500 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 243243012501 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 243243012502 active site 243243012503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 243243012504 DNA binding site [nucleotide binding] 243243012505 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 243243012506 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 243243012507 putative active site [active] 243243012508 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 243243012509 putative active site [active] 243243012510 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 243243012511 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 243243012512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243012513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243012514 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243243012515 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243243012516 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243243012517 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243243012518 putative dimer interface [polypeptide binding]; other site 243243012519 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 243243012520 L-aspartate oxidase; Provisional; Region: PRK06175 243243012521 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243243012522 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 243243012523 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243012524 catalytic loop [active] 243243012525 iron binding site [ion binding]; other site 243243012526 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 243243012527 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 243243012528 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 243243012529 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 243243012530 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 243243012531 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 243243012532 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 243243012533 FAD binding site [chemical binding]; other site 243243012534 substrate binding site [chemical binding]; other site 243243012535 catalytic residues [active] 243243012536 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 243243012537 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 243243012538 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243012539 dimer interface [polypeptide binding]; other site 243243012540 active site 243243012541 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 243243012542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243012543 NAD(P) binding site [chemical binding]; other site 243243012544 active site 243243012545 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243012546 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243012547 active site 2 [active] 243243012548 active site 1 [active] 243243012549 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 243243012550 Cl- selectivity filter; other site 243243012551 Cl- binding residues [ion binding]; other site 243243012552 pore gating glutamate residue; other site 243243012553 dimer interface [polypeptide binding]; other site 243243012554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012556 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 243243012557 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 243243012558 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 243243012559 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 243243012560 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 243243012561 Lipase maturation factor; Region: LMF1; pfam06762 243243012562 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 243243012563 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243243012564 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 243243012565 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 243243012566 heme binding pocket [chemical binding]; other site 243243012567 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 243243012568 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 243243012569 heme binding pocket [chemical binding]; other site 243243012570 formate dehydrogenase; Provisional; Region: PRK07574 243243012571 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 243243012572 NAD binding site [chemical binding]; other site 243243012573 Predicted membrane protein [Function unknown]; Region: COG4129 243243012574 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 243243012575 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243243012576 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243243012577 active site 243243012578 metal binding site [ion binding]; metal-binding site 243243012579 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 243243012580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243243012581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243012582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243243012583 dimerization interface [polypeptide binding]; other site 243243012584 acetolactate synthase; Reviewed; Region: PRK08322 243243012585 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243243012586 PYR/PP interface [polypeptide binding]; other site 243243012587 dimer interface [polypeptide binding]; other site 243243012588 TPP binding site [chemical binding]; other site 243243012589 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243243012590 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 243243012591 TPP-binding site [chemical binding]; other site 243243012592 dimer interface [polypeptide binding]; other site 243243012593 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 243243012594 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 243243012595 NAD(P) binding site [chemical binding]; other site 243243012596 catalytic residues [active] 243243012597 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 243243012598 active site 243243012599 diiron metal binding site [ion binding]; other site 243243012600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012602 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243012603 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243012604 active site 243243012605 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 243243012606 active site 243243012607 substrate binding pocket [chemical binding]; other site 243243012608 homodimer interaction site [polypeptide binding]; other site 243243012609 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243012610 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 243243012611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243243012612 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243243012613 Methyltransferase domain; Region: Methyltransf_11; pfam08241 243243012614 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 243243012615 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243012616 NAD binding site [chemical binding]; other site 243243012617 catalytic residues [active] 243243012618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012620 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243012621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243012622 acyl-activating enzyme (AAE) consensus motif; other site 243243012623 AMP binding site [chemical binding]; other site 243243012624 active site 243243012625 CoA binding site [chemical binding]; other site 243243012626 enoyl-CoA hydratase; Provisional; Region: PRK08252 243243012627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243012628 substrate binding site [chemical binding]; other site 243243012629 oxyanion hole (OAH) forming residues; other site 243243012630 trimer interface [polypeptide binding]; other site 243243012631 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 243243012632 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 243243012633 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243012634 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243012635 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243012636 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243012637 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243012638 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243012639 active site 243243012640 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243012641 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243012642 active site 2 [active] 243243012643 active site 1 [active] 243243012644 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243012645 active site 2 [active] 243243012646 active site 1 [active] 243243012647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243012648 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243012649 active site 243243012650 Interferon-induced transmembrane protein; Region: CD225; pfam04505 243243012651 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243012652 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243012653 substrate binding site [chemical binding]; other site 243243012654 oxyanion hole (OAH) forming residues; other site 243243012655 trimer interface [polypeptide binding]; other site 243243012656 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 243243012657 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243012658 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243012659 acyl-activating enzyme (AAE) consensus motif; other site 243243012660 acyl-activating enzyme (AAE) consensus motif; other site 243243012661 putative AMP binding site [chemical binding]; other site 243243012662 putative active site [active] 243243012663 putative CoA binding site [chemical binding]; other site 243243012664 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243243012665 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243243012666 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243243012667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243243012668 metal binding site [ion binding]; metal-binding site 243243012669 active site 243243012670 I-site; other site 243243012671 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 243243012672 active site 243243012673 substrate-binding site [chemical binding]; other site 243243012674 metal-binding site [ion binding] 243243012675 GTP binding site [chemical binding]; other site 243243012676 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243243012677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243012678 S-adenosylmethionine binding site [chemical binding]; other site 243243012679 LabA_like proteins; Region: LabA_like; cd06167 243243012680 putative metal binding site [ion binding]; other site 243243012681 MMPL family; Region: MMPL; pfam03176 243243012682 MMPL family; Region: MMPL; pfam03176 243243012683 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243243012684 Domain of unknown function DUF20; Region: UPF0118; pfam01594 243243012685 Predicted integral membrane protein [Function unknown]; Region: COG0392 243243012686 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 243243012687 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 243243012688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 243243012689 non-specific DNA binding site [nucleotide binding]; other site 243243012690 salt bridge; other site 243243012691 sequence-specific DNA binding site [nucleotide binding]; other site 243243012692 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 243243012693 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 243243012694 active site 243243012695 Zn binding site [ion binding]; other site 243243012696 Ferritin-like domain; Region: Ferritin; pfam00210 243243012697 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 243243012698 dimerization interface [polypeptide binding]; other site 243243012699 DPS ferroxidase diiron center [ion binding]; other site 243243012700 ion pore; other site 243243012701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243243012702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243012703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243243012704 dimerization interface [polypeptide binding]; other site 243243012705 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 243243012706 Protein HOTHEAD; Region: PLN02785 243243012707 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 243243012708 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 243243012709 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 243243012710 conserved cys residue [active] 243243012711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243243012712 short chain dehydrogenase; Provisional; Region: PRK06180 243243012713 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 243243012714 NADP binding site [chemical binding]; other site 243243012715 active site 243243012716 steroid binding site; other site 243243012717 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243012718 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 243243012719 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243012720 molybdopterin cofactor binding site; other site 243243012721 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243243012722 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 243243012723 putative molybdopterin cofactor binding site; other site 243243012724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012725 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 243243012726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243243012727 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243243012728 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 243243012729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243243012730 putative substrate translocation pore; other site 243243012731 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 243243012732 putative homodimer interface [polypeptide binding]; other site 243243012733 putative homotetramer interface [polypeptide binding]; other site 243243012734 putative allosteric switch controlling residues; other site 243243012735 putative metal binding site [ion binding]; other site 243243012736 putative homodimer-homodimer interface [polypeptide binding]; other site 243243012737 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 243243012738 6-phosphogluconate dehydratase; Region: edd; TIGR01196 243243012739 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243243012740 FMN binding site [chemical binding]; other site 243243012741 substrate binding site [chemical binding]; other site 243243012742 putative catalytic residue [active] 243243012743 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 243243012744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243012745 S-adenosylmethionine binding site [chemical binding]; other site 243243012746 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 243243012747 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 243243012748 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 243243012749 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 243243012750 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 243243012751 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 243243012752 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 243243012753 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243012754 RNA polymerase factor sigma-70; Validated; Region: PRK08241 243243012755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243012756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243012757 DNA binding residues [nucleotide binding] 243243012758 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243012759 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243243012760 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243012761 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243243012762 Bacterial transcriptional regulator; Region: IclR; pfam01614 243243012763 Pirin; Region: Pirin; pfam02678 243243012764 Pirin-related protein [General function prediction only]; Region: COG1741 243243012765 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 243243012766 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 243243012767 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 243243012768 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 243243012769 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 243243012770 RDD family; Region: RDD; pfam06271 243243012771 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243243012772 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243012773 mce related protein; Region: MCE; pfam02470 243243012774 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243012775 mce related protein; Region: MCE; pfam02470 243243012776 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243012777 mce related protein; Region: MCE; pfam02470 243243012778 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243243012779 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243012780 mce related protein; Region: MCE; pfam02470 243243012781 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243012782 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243012783 mce related protein; Region: MCE; pfam02470 243243012784 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 243243012785 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243012786 Permease; Region: Permease; pfam02405 243243012787 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243243012788 Permease; Region: Permease; pfam02405 243243012789 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 243243012790 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243012791 acyl-activating enzyme (AAE) consensus motif; other site 243243012792 AMP binding site [chemical binding]; other site 243243012793 active site 243243012794 CoA binding site [chemical binding]; other site 243243012795 transcriptional regulator NanR; Provisional; Region: PRK03837 243243012796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243012797 DNA-binding site [nucleotide binding]; DNA binding site 243243012798 FCD domain; Region: FCD; pfam07729 243243012799 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 243243012800 putative hydrophobic ligand binding site [chemical binding]; other site 243243012801 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243243012802 active site 243243012803 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243243012804 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 243243012805 NAD(P) binding site [chemical binding]; other site 243243012806 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 243243012807 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 243243012808 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243243012809 ATP binding site [chemical binding]; other site 243243012810 putative Mg++ binding site [ion binding]; other site 243243012811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243243012812 nucleotide binding region [chemical binding]; other site 243243012813 ATP-binding site [chemical binding]; other site 243243012814 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 243243012815 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 243243012816 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243243012817 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 243243012818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243012819 S-adenosylmethionine binding site [chemical binding]; other site 243243012820 RadC-like JAB domain; Region: RadC; pfam04002 243243012821 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243012822 MULE transposase domain; Region: MULE; pfam10551 243243012823 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243243012824 UTRA domain; Region: UTRA; pfam07702 243243012825 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 243243012826 Uncharacterized conserved protein [Function unknown]; Region: COG1262 243243012827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243243012828 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243243012829 Transposase; Region: HTH_Tnp_1; cl17663 243243012830 putative transposase OrfB; Reviewed; Region: PHA02517 243243012831 HTH-like domain; Region: HTH_21; pfam13276 243243012832 Integrase core domain; Region: rve; pfam00665 243243012833 Integrase core domain; Region: rve_3; cl15866 243243012834 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243243012835 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243012836 MULE transposase domain; Region: MULE; pfam10551 243243012837 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243012838 MULE transposase domain; Region: MULE; pfam10551 243243012839 probable pectinesterase/pectinesterase inhibitor; Region: PLN02217 243243012840 mce related protein; Region: MCE; pfam02470 243243012841 mce related protein; Region: MCE; pfam02470 243243012842 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243012843 mce related protein; Region: MCE; pfam02470 243243012844 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 243243012845 mce related protein; Region: MCE; pfam02470 243243012846 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243243012847 mce related protein; Region: MCE; pfam02470 243243012848 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243243012849 mce related protein; Region: MCE; pfam02470 243243012850 Permease; Region: Permease; pfam02405 243243012851 tetracycline repressor protein TetR; Provisional; Region: PRK13756 243243012852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012853 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243243012854 pyruvate phosphate dikinase; Provisional; Region: PRK05878 243243012855 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243243012856 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243243012857 Phosphotransferase enzyme family; Region: APH; pfam01636 243243012858 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243012859 putative active site [active] 243243012860 putative substrate binding site [chemical binding]; other site 243243012861 ATP binding site [chemical binding]; other site 243243012862 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 243243012863 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 243243012864 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243243012865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243012869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243012870 active site 243243012871 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 243243012872 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243012873 dimer interface [polypeptide binding]; other site 243243012874 active site 243243012875 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243012876 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243012877 active site 243243012878 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 243243012879 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 243243012880 4Fe-4S binding domain; Region: Fer4; pfam00037 243243012881 ferredoxin-NADP+ reductase; Region: PLN02852 243243012882 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 243243012883 Phosphotransferase enzyme family; Region: APH; pfam01636 243243012884 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243012885 putative active site [active] 243243012886 ATP binding site [chemical binding]; other site 243243012887 putative substrate binding site [chemical binding]; other site 243243012888 AMP-binding domain protein; Validated; Region: PRK08315 243243012889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243012890 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 243243012891 acyl-activating enzyme (AAE) consensus motif; other site 243243012892 putative AMP binding site [chemical binding]; other site 243243012893 putative active site [active] 243243012894 putative CoA binding site [chemical binding]; other site 243243012895 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243243012896 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243012897 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 243243012898 acyl-activating enzyme (AAE) consensus motif; other site 243243012899 acyl-activating enzyme (AAE) consensus motif; other site 243243012900 putative AMP binding site [chemical binding]; other site 243243012901 putative active site [active] 243243012902 putative CoA binding site [chemical binding]; other site 243243012903 short chain dehydrogenase; Provisional; Region: PRK12939 243243012904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243012905 NAD(P) binding site [chemical binding]; other site 243243012906 active site 243243012907 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 243243012908 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243012909 active site 243243012910 hypothetical protein; Provisional; Region: PRK04262 243243012911 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243243012912 active site 243243012913 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243012914 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243012915 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 243243012916 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 243243012917 dimer interface [polypeptide binding]; other site 243243012918 active site 243243012919 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 243243012920 inter-subunit interface; other site 243243012921 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 243243012922 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243243012923 iron-sulfur cluster [ion binding]; other site 243243012924 [2Fe-2S] cluster binding site [ion binding]; other site 243243012925 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 243243012926 putative alpha subunit interface [polypeptide binding]; other site 243243012927 putative active site [active] 243243012928 putative substrate binding site [chemical binding]; other site 243243012929 Fe binding site [ion binding]; other site 243243012930 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243012931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243012932 substrate binding site [chemical binding]; other site 243243012933 oxyanion hole (OAH) forming residues; other site 243243012934 trimer interface [polypeptide binding]; other site 243243012935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 243243012936 enoyl-CoA hydratase; Provisional; Region: PRK06688 243243012937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243012938 substrate binding site [chemical binding]; other site 243243012939 oxyanion hole (OAH) forming residues; other site 243243012940 trimer interface [polypeptide binding]; other site 243243012941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 243243012942 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 243243012943 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243243012944 substrate binding site [chemical binding]; other site 243243012945 oxyanion hole (OAH) forming residues; other site 243243012946 trimer interface [polypeptide binding]; other site 243243012947 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243012948 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243243012949 NAD(P) binding site [chemical binding]; other site 243243012950 homotetramer interface [polypeptide binding]; other site 243243012951 homodimer interface [polypeptide binding]; other site 243243012952 active site 243243012953 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243243012954 classical (c) SDRs; Region: SDR_c; cd05233 243243012955 NAD(P) binding site [chemical binding]; other site 243243012956 active site 243243012957 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 243243012958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243243012959 putative transposase OrfB; Reviewed; Region: PHA02517 243243012960 HTH-like domain; Region: HTH_21; pfam13276 243243012961 Integrase core domain; Region: rve; pfam00665 243243012962 Integrase core domain; Region: rve_3; cl15866 243243012963 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243243012964 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 243243012965 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 243243012966 NAD(P) binding site [chemical binding]; other site 243243012967 catalytic residues [active] 243243012968 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 243243012969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243012970 NAD(P) binding site [chemical binding]; other site 243243012971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243012972 active site 243243012973 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243012974 Cytochrome P450; Region: p450; cl12078 243243012975 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 243243012976 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243012977 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 243243012978 acyl-activating enzyme (AAE) consensus motif; other site 243243012979 putative AMP binding site [chemical binding]; other site 243243012980 putative active site [active] 243243012981 acyl-activating enzyme (AAE) consensus motif; other site 243243012982 putative CoA binding site [chemical binding]; other site 243243012983 SCP-2 sterol transfer family; Region: SCP2; pfam02036 243243012984 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243243012985 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243243012986 Walker A/P-loop; other site 243243012987 ATP binding site [chemical binding]; other site 243243012988 Q-loop/lid; other site 243243012989 ABC transporter signature motif; other site 243243012990 Walker B; other site 243243012991 D-loop; other site 243243012992 H-loop/switch region; other site 243243012993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243012994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243012995 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243012996 active site 2 [active] 243243012997 active site 1 [active] 243243012998 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243243012999 active site 2 [active] 243243013000 active site 1 [active] 243243013001 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243013002 MULE transposase domain; Region: MULE; pfam10551 243243013003 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243243013004 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243243013005 ligand binding site [chemical binding]; other site 243243013006 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 243243013007 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 243243013008 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 243243013009 active site 243243013010 substrate-binding site [chemical binding]; other site 243243013011 metal-binding site [ion binding] 243243013012 GTP binding site [chemical binding]; other site 243243013013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243243013014 dimerization interface [polypeptide binding]; other site 243243013015 putative DNA binding site [nucleotide binding]; other site 243243013016 putative Zn2+ binding site [ion binding]; other site 243243013017 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 243243013018 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 243243013019 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 243243013020 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243243013021 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 243243013022 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 243243013023 NADH dehydrogenase; Region: NADHdh; cl00469 243243013024 hydrogenase 4 subunit B; Validated; Region: PRK06521 243243013025 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243243013026 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 243243013027 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243243013028 MULE transposase domain; Region: MULE; pfam10551 243243013029 hypothetical protein; Reviewed; Region: PRK00024 243243013030 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 243243013031 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 243243013032 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243013033 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243013034 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 243243013035 classical (c) SDRs; Region: SDR_c; cd05233 243243013036 NAD(P) binding site [chemical binding]; other site 243243013037 active site 243243013038 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 243243013039 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 243243013040 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243243013041 putative NAD(P) binding site [chemical binding]; other site 243243013042 catalytic Zn binding site [ion binding]; other site 243243013043 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243013044 Cytochrome P450; Region: p450; cl12078 243243013045 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243013046 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243013047 Domain of unknown function (DUF427); Region: DUF427; pfam04248 243243013048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243013049 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243013050 active site 243243013051 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 243243013052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243013053 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 243243013054 acyl-CoA thioesterase II; Region: tesB; TIGR00189 243243013055 active site 243243013056 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 243243013057 catalytic triad [active] 243243013058 dimer interface [polypeptide binding]; other site 243243013059 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243243013060 hydrophobic ligand binding site; other site 243243013061 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243243013062 Strictosidine synthase; Region: Str_synth; pfam03088 243243013063 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 243243013064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013066 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243243013067 FAD binding domain; Region: FAD_binding_4; pfam01565 243243013068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243013069 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243013070 NAD(P) binding site [chemical binding]; other site 243243013071 active site 243243013072 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 243243013073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013075 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 243243013076 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 243243013077 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 243243013078 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 243243013079 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 243243013080 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 243243013081 ligand binding site [chemical binding]; other site 243243013082 homodimer interface [polypeptide binding]; other site 243243013083 NAD(P) binding site [chemical binding]; other site 243243013084 trimer interface B [polypeptide binding]; other site 243243013085 trimer interface A [polypeptide binding]; other site 243243013086 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 243243013087 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243013088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243013089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243013090 active site 243243013091 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 243243013092 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 243243013093 short chain dehydrogenase; Provisional; Region: PRK07791 243243013094 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 243243013095 NAD binding site [chemical binding]; other site 243243013096 homodimer interface [polypeptide binding]; other site 243243013097 active site 243243013098 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 243243013099 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 243243013100 NAD(P) binding site [chemical binding]; other site 243243013101 catalytic residues [active] 243243013102 Transcriptional regulator [Transcription]; Region: LytR; COG1316 243243013103 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 243243013104 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243013105 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243013106 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 243243013107 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 243243013108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013110 Pirin-related protein [General function prediction only]; Region: COG1741 243243013111 Pirin; Region: Pirin; pfam02678 243243013112 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 243243013113 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 243243013114 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 243243013115 dimerization interface [polypeptide binding]; other site 243243013116 DPS ferroxidase diiron center [ion binding]; other site 243243013117 ion pore; other site 243243013118 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 243243013119 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243243013120 minor groove reading motif; other site 243243013121 helix-hairpin-helix signature motif; other site 243243013122 active site 243243013123 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 243243013124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 243243013125 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 243243013126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243013127 NAD(P) binding site [chemical binding]; other site 243243013128 active site 243243013129 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243013130 methionine sulfoxide reductase A; Provisional; Region: PRK14054 243243013131 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243243013132 Cytochrome P450; Region: p450; cl12078 243243013133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013135 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 243243013136 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243013137 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 243243013138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013140 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 243243013141 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 243243013142 putative di-iron ligands [ion binding]; other site 243243013143 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 243243013144 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 243243013145 FAD binding pocket [chemical binding]; other site 243243013146 FAD binding motif [chemical binding]; other site 243243013147 phosphate binding motif [ion binding]; other site 243243013148 beta-alpha-beta structure motif; other site 243243013149 NAD binding pocket [chemical binding]; other site 243243013150 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243243013151 catalytic loop [active] 243243013152 iron binding site [ion binding]; other site 243243013153 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 243243013154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 243243013156 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 243243013157 Coenzyme A binding pocket [chemical binding]; other site 243243013158 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 243243013159 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 243243013160 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 243243013161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 243243013162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 243243013163 active site 243243013164 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 243243013165 putative active site [active] 243243013166 putative catalytic site [active] 243243013167 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243013168 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243243013169 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 243243013170 TAP-like protein; Region: Abhydrolase_4; pfam08386 243243013171 Domain of unknown function DUF302; Region: DUF302; pfam03625 243243013172 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 243243013173 putative homodimer interface [polypeptide binding]; other site 243243013174 putative homotetramer interface [polypeptide binding]; other site 243243013175 putative allosteric switch controlling residues; other site 243243013176 putative metal binding site [ion binding]; other site 243243013177 putative homodimer-homodimer interface [polypeptide binding]; other site 243243013178 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 243243013179 active site 243243013180 metal binding site [ion binding]; metal-binding site 243243013181 homotetramer interface [polypeptide binding]; other site 243243013182 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243243013183 MarR family; Region: MarR_2; pfam12802 243243013184 Low affinity iron permease; Region: Iron_permease; cl12096 243243013185 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 243243013186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243243013187 Walker A/P-loop; other site 243243013188 ATP binding site [chemical binding]; other site 243243013189 Q-loop/lid; other site 243243013190 ABC transporter signature motif; other site 243243013191 Walker B; other site 243243013192 D-loop; other site 243243013193 H-loop/switch region; other site 243243013194 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243243013195 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243243013196 Putative esterase; Region: Esterase; pfam00756 243243013197 Predicted membrane protein [Function unknown]; Region: COG3619 243243013198 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 243243013199 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 243243013200 trehalose synthase; Region: treS_nterm; TIGR02456 243243013201 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 243243013202 active site 243243013203 catalytic site [active] 243243013204 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243243013205 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243243013206 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 243243013207 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 243243013208 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243243013209 elongation factor G; Reviewed; Region: PRK12740 243243013210 G1 box; other site 243243013211 GTP/Mg2+ binding site [chemical binding]; other site 243243013212 G2 box; other site 243243013213 Switch I region; other site 243243013214 G3 box; other site 243243013215 Switch II region; other site 243243013216 G4 box; other site 243243013217 G5 box; other site 243243013218 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243243013219 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243243013220 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243243013221 acyl-CoA synthetase; Validated; Region: PRK05852 243243013222 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243013223 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 243243013224 acyl-activating enzyme (AAE) consensus motif; other site 243243013225 acyl-activating enzyme (AAE) consensus motif; other site 243243013226 putative AMP binding site [chemical binding]; other site 243243013227 putative active site [active] 243243013228 putative CoA binding site [chemical binding]; other site 243243013229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243243013230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243243013231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243243013232 dimerization interface [polypeptide binding]; other site 243243013233 Isochorismatase family; Region: Isochorismatase; pfam00857 243243013234 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 243243013235 catalytic triad [active] 243243013236 conserved cis-peptide bond; other site 243243013237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243243013238 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 243243013239 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243243013240 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243243013241 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 243243013242 putative NAD(P) binding site [chemical binding]; other site 243243013243 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 243243013244 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 243243013245 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 243243013246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243013247 S-adenosylmethionine binding site [chemical binding]; other site 243243013248 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243243013249 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 243243013250 active site 243243013251 catalytic triad [active] 243243013252 oxyanion hole [active] 243243013253 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 243243013254 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 243243013255 NAD binding site [chemical binding]; other site 243243013256 catalytic residues [active] 243243013257 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 243243013258 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243243013259 PYR/PP interface [polypeptide binding]; other site 243243013260 dimer interface [polypeptide binding]; other site 243243013261 TPP binding site [chemical binding]; other site 243243013262 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243243013263 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 243243013264 TPP-binding site; other site 243243013265 dimer interface [polypeptide binding]; other site 243243013266 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243013267 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243013268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243013269 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 243243013270 NAD(P) binding site [chemical binding]; other site 243243013271 active site 243243013272 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243013273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243013274 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243013275 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243013276 [2Fe-2S] cluster binding site [ion binding]; other site 243243013277 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 243243013278 putative alpha subunit interface [polypeptide binding]; other site 243243013279 putative active site [active] 243243013280 putative substrate binding site [chemical binding]; other site 243243013281 Fe binding site [ion binding]; other site 243243013282 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 243243013283 classical (c) SDRs; Region: SDR_c; cd05233 243243013284 NAD(P) binding site [chemical binding]; other site 243243013285 active site 243243013286 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243243013287 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243243013288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243243013289 DNA-binding site [nucleotide binding]; DNA binding site 243243013290 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 243243013291 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 243243013292 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 243243013293 acyl-activating enzyme (AAE) consensus motif; other site 243243013294 putative AMP binding site [chemical binding]; other site 243243013295 putative active site [active] 243243013296 putative CoA binding site [chemical binding]; other site 243243013297 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 243243013298 classical (c) SDRs; Region: SDR_c; cd05233 243243013299 NAD(P) binding site [chemical binding]; other site 243243013300 active site 243243013301 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 243243013302 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 243243013303 NAD binding site [chemical binding]; other site 243243013304 catalytic Zn binding site [ion binding]; other site 243243013305 substrate binding site [chemical binding]; other site 243243013306 structural Zn binding site [ion binding]; other site 243243013307 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 243243013308 hydrophobic ligand binding site; other site 243243013309 SnoaL-like domain; Region: SnoaL_2; pfam12680 243243013310 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243243013311 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 243243013312 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243243013313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243243013314 motif II; other site 243243013315 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243243013316 acyl-CoA synthetase; Provisional; Region: PRK13383 243243013317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243013318 acyl-activating enzyme (AAE) consensus motif; other site 243243013319 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243013320 AMP binding site [chemical binding]; other site 243243013321 active site 243243013322 acyl-activating enzyme (AAE) consensus motif; other site 243243013323 CoA binding site [chemical binding]; other site 243243013324 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243243013325 classical (c) SDRs; Region: SDR_c; cd05233 243243013326 NAD(P) binding site [chemical binding]; other site 243243013327 active site 243243013328 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243243013329 NAD(P) binding site [chemical binding]; other site 243243013330 catalytic residues [active] 243243013331 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 243243013332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243013333 NAD(P) binding site [chemical binding]; other site 243243013334 active site 243243013335 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 243243013336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013338 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243243013339 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 243243013340 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 243243013341 cyclase homology domain; Region: CHD; cd07302 243243013342 nucleotidyl binding site; other site 243243013343 metal binding site [ion binding]; metal-binding site 243243013344 dimer interface [polypeptide binding]; other site 243243013345 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243243013346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243243013347 S-adenosylmethionine binding site [chemical binding]; other site 243243013348 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 243243013349 putative hydrophobic ligand binding site [chemical binding]; other site 243243013350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243013351 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 243243013352 NAD(P) binding site [chemical binding]; other site 243243013353 active site 243243013354 Predicted membrane protein [Function unknown]; Region: COG3305 243243013355 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243243013356 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243243013357 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 243243013358 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 243243013359 putative NAD(P) binding site [chemical binding]; other site 243243013360 catalytic Zn binding site [ion binding]; other site 243243013361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 243243013362 SnoaL-like domain; Region: SnoaL_3; pfam13474 243243013363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243243013364 NAD(P) binding site [chemical binding]; other site 243243013365 active site 243243013366 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 243243013367 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243243013368 classical (c) SDRs; Region: SDR_c; cd05233 243243013369 NAD(P) binding site [chemical binding]; other site 243243013370 active site 243243013371 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 243243013372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 243243013373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243013374 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 243243013375 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243243013376 hydrophobic ligand binding site; other site 243243013377 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 243243013378 classical (c) SDRs; Region: SDR_c; cd05233 243243013379 NAD(P) binding site [chemical binding]; other site 243243013380 active site 243243013381 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243243013382 metal-binding site [ion binding] 243243013383 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243243013384 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243243013385 metal-binding site [ion binding] 243243013386 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243243013387 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243243013388 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 243243013389 NodB motif; other site 243243013390 active site 243243013391 catalytic site [active] 243243013392 metal binding site [ion binding]; metal-binding site 243243013393 MarR family; Region: MarR_2; pfam12802 243243013394 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 243243013395 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243243013396 Secretory lipase; Region: LIP; pfam03583 243243013397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 243243013398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013400 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243243013401 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243243013402 classical (c) SDRs; Region: SDR_c; cd05233 243243013403 NAD(P) binding site [chemical binding]; other site 243243013404 active site 243243013405 acyl-CoA synthetase; Provisional; Region: PRK13388 243243013406 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243243013407 acyl-activating enzyme (AAE) consensus motif; other site 243243013408 AMP binding site [chemical binding]; other site 243243013409 active site 243243013410 CoA binding site [chemical binding]; other site 243243013411 Predicted transcriptional regulators [Transcription]; Region: COG1695 243243013412 MarR family; Region: MarR_2; cl17246 243243013413 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 243243013414 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243013415 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243013416 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 243243013417 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243013418 active site 243243013419 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243013420 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243013421 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 243243013422 CoA-transferase family III; Region: CoA_transf_3; pfam02515 243243013423 Amidohydrolase; Region: Amidohydro_2; pfam04909 243243013424 Transcriptional regulators [Transcription]; Region: PurR; COG1609 243243013425 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 243243013426 DNA binding site [nucleotide binding] 243243013427 domain linker motif; other site 243243013428 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 243243013429 dimerization interface [polypeptide binding]; other site 243243013430 ligand binding site [chemical binding]; other site 243243013431 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 243243013432 DUF35 OB-fold domain; Region: DUF35; pfam01796 243243013433 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 243243013434 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243243013435 active site 243243013436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013438 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 243243013439 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 243243013440 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 243243013441 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 243243013442 putative active site [active] 243243013443 catalytic residue [active] 243243013444 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243243013445 anti sigma factor interaction site; other site 243243013446 regulatory phosphorylation site [posttranslational modification]; other site 243243013447 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 243243013448 Phosphotransferase enzyme family; Region: APH; pfam01636 243243013449 putative active site [active] 243243013450 ATP binding site [chemical binding]; other site 243243013451 putative substrate binding site [chemical binding]; other site 243243013452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243243013453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243243013454 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243243013455 Ecdysteroid kinase; Region: EcKinase; cl17738 243243013456 Phosphotransferase enzyme family; Region: APH; pfam01636 243243013457 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 243243013458 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 243243013459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243013460 active site 243243013461 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243243013462 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243243013463 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 243243013464 [2Fe-2S] cluster binding site [ion binding]; other site 243243013465 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 243243013466 putative alpha subunit interface [polypeptide binding]; other site 243243013467 putative active site [active] 243243013468 putative substrate binding site [chemical binding]; other site 243243013469 Fe binding site [ion binding]; other site 243243013470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243243013471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243243013472 active site 243243013473 phosphorylation site [posttranslational modification] 243243013474 intermolecular recognition site; other site 243243013475 dimerization interface [polypeptide binding]; other site 243243013476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243243013477 DNA binding residues [nucleotide binding] 243243013478 dimerization interface [polypeptide binding]; other site 243243013479 Histidine kinase; Region: HisKA_3; pfam07730 243243013480 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 243243013481 ATP binding site [chemical binding]; other site 243243013482 Mg2+ binding site [ion binding]; other site 243243013483 Transport protein; Region: actII; TIGR00833 243243013484 Protein of unknown function (DUF690); Region: DUF690; pfam05108 243243013485 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 243243013486 catalytic residue [active] 243243013487 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 243243013488 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 243243013489 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 243243013490 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243243013491 active site 243243013492 NTP binding site [chemical binding]; other site 243243013493 metal binding triad [ion binding]; metal-binding site 243243013494 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243243013495 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243243013496 Zn2+ binding site [ion binding]; other site 243243013497 Mg2+ binding site [ion binding]; other site 243243013498 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 243243013499 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 243243013500 active site 243243013501 Ap6A binding site [chemical binding]; other site 243243013502 nudix motif; other site 243243013503 metal binding site [ion binding]; metal-binding site 243243013504 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 243243013505 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 243243013506 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 243243013507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243243013508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243243013509 DNA binding residues [nucleotide binding] 243243013510 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 243243013511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243243013512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243243013513 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243243013514 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243243013515 catalytic residues [active] 243243013516 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 243243013517 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243243013518 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243243013519 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 243243013520 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 243243013521 active site 243243013522 metal binding site [ion binding]; metal-binding site 243243013523 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 243243013524 ParB-like nuclease domain; Region: ParBc; pfam02195 243243013525 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243243013526 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243243013527 P-loop; other site 243243013528 Magnesium ion binding site [ion binding]; other site 243243013529 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243243013530 Magnesium ion binding site [ion binding]; other site 243243013531 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243243013532 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 243243013533 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 243243013534 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 243243013535 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 243243013536 G-X-X-G motif; other site 243243013537 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 243243013538 RxxxH motif; other site 243243013539 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 243243013540 hypothetical protein; Validated; Region: PRK00041 243243013541 ribonuclease P; Reviewed; Region: rnpA; PRK00588 243243013542 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399