-- dump date 20140619_151230 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1199187000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1199187000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187000003 Walker A motif; other site 1199187000004 ATP binding site [chemical binding]; other site 1199187000005 Walker B motif; other site 1199187000006 arginine finger; other site 1199187000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1199187000008 DnaA box-binding interface [nucleotide binding]; other site 1199187000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1199187000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1199187000011 putative DNA binding surface [nucleotide binding]; other site 1199187000012 dimer interface [polypeptide binding]; other site 1199187000013 beta-clamp/clamp loader binding surface; other site 1199187000014 beta-clamp/translesion DNA polymerase binding surface; other site 1199187000015 recombination protein F; Reviewed; Region: recF; PRK00064 1199187000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1199187000017 Walker A/P-loop; other site 1199187000018 ATP binding site [chemical binding]; other site 1199187000019 Q-loop/lid; other site 1199187000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187000021 ABC transporter signature motif; other site 1199187000022 Walker B; other site 1199187000023 D-loop; other site 1199187000024 H-loop/switch region; other site 1199187000025 hypothetical protein; Provisional; Region: PRK03195 1199187000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1199187000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187000028 Mg2+ binding site [ion binding]; other site 1199187000029 G-X-G motif; other site 1199187000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1199187000031 anchoring element; other site 1199187000032 dimer interface [polypeptide binding]; other site 1199187000033 ATP binding site [chemical binding]; other site 1199187000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1199187000035 active site 1199187000036 putative metal-binding site [ion binding]; other site 1199187000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1199187000038 DNA gyrase subunit A; Validated; Region: PRK05560 1199187000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1199187000040 CAP-like domain; other site 1199187000041 active site 1199187000042 primary dimer interface [polypeptide binding]; other site 1199187000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1199187000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1199187000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1199187000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1199187000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1199187000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1199187000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1199187000050 Helix-turn-helix domain; Region: HTH_28; pfam13518 1199187000051 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187000052 Homeodomain-like domain; Region: HTH_32; pfam13565 1199187000053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187000054 Integrase core domain; Region: rve; pfam00665 1199187000055 Integrase core domain; Region: rve_3; pfam13683 1199187000056 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1199187000057 MULE transposase domain; Region: MULE; pfam10551 1199187000058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1199187000059 Helix-turn-helix domain; Region: HTH_18; pfam12833 1199187000060 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 1199187000061 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1199187000062 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187000063 Transposase; Region: HTH_Tnp_1; cl17663 1199187000064 acyl-CoA synthetase; Validated; Region: PRK05850 1199187000065 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1199187000066 acyl-activating enzyme (AAE) consensus motif; other site 1199187000067 active site 1199187000068 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1199187000069 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187000070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187000071 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187000072 NAD(P) binding site [chemical binding]; other site 1199187000073 active site 1199187000074 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187000075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1199187000076 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187000077 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1199187000078 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1199187000079 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1199187000080 putative homodimer interface [polypeptide binding]; other site 1199187000081 putative homotetramer interface [polypeptide binding]; other site 1199187000082 putative allosteric switch controlling residues; other site 1199187000083 putative metal binding site [ion binding]; other site 1199187000084 putative homodimer-homodimer interface [polypeptide binding]; other site 1199187000085 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1199187000086 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 1199187000087 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1199187000088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187000089 NAD(P) binding site [chemical binding]; other site 1199187000090 acyl-CoA synthetase; Validated; Region: PRK05850 1199187000091 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1199187000092 acyl-activating enzyme (AAE) consensus motif; other site 1199187000093 active site 1199187000094 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1199187000095 Condensation domain; Region: Condensation; pfam00668 1199187000096 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1199187000097 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1199187000098 acyl-activating enzyme (AAE) consensus motif; other site 1199187000099 AMP binding site [chemical binding]; other site 1199187000100 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187000101 Condensation domain; Region: Condensation; pfam00668 1199187000102 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187000103 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1199187000104 Condensation domain; Region: Condensation; pfam00668 1199187000105 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187000106 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1199187000107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187000108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187000109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1199187000110 putative substrate translocation pore; other site 1199187000111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187000112 putative substrate translocation pore; other site 1199187000113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187000114 S-adenosylmethionine binding site [chemical binding]; other site 1199187000115 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187000116 PPE family; Region: PPE; pfam00823 1199187000117 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1199187000118 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1199187000119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187000120 Walker A/P-loop; other site 1199187000121 ATP binding site [chemical binding]; other site 1199187000122 Q-loop/lid; other site 1199187000123 ABC transporter signature motif; other site 1199187000124 Walker B; other site 1199187000125 D-loop; other site 1199187000126 H-loop/switch region; other site 1199187000127 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1199187000128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187000129 Walker A/P-loop; other site 1199187000130 ATP binding site [chemical binding]; other site 1199187000131 Q-loop/lid; other site 1199187000132 ABC transporter signature motif; other site 1199187000133 Walker B; other site 1199187000134 D-loop; other site 1199187000135 H-loop/switch region; other site 1199187000136 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 1199187000137 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1199187000138 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1199187000139 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1199187000140 Walker A/P-loop; other site 1199187000141 ATP binding site [chemical binding]; other site 1199187000142 Q-loop/lid; other site 1199187000143 ABC transporter signature motif; other site 1199187000144 Walker B; other site 1199187000145 D-loop; other site 1199187000146 H-loop/switch region; other site 1199187000147 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 1199187000148 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1199187000149 Walker A/P-loop; other site 1199187000150 ATP binding site [chemical binding]; other site 1199187000151 Q-loop/lid; other site 1199187000152 ABC transporter signature motif; other site 1199187000153 Walker B; other site 1199187000154 D-loop; other site 1199187000155 H-loop/switch region; other site 1199187000156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187000157 S-adenosylmethionine binding site [chemical binding]; other site 1199187000158 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1199187000159 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1199187000160 substrate binding pocket [chemical binding]; other site 1199187000161 active site 1199187000162 iron coordination sites [ion binding]; other site 1199187000163 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1199187000164 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1199187000165 intersubunit interface [polypeptide binding]; other site 1199187000166 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1199187000167 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1199187000168 Walker A/P-loop; other site 1199187000169 ATP binding site [chemical binding]; other site 1199187000170 Q-loop/lid; other site 1199187000171 ABC transporter signature motif; other site 1199187000172 Walker B; other site 1199187000173 D-loop; other site 1199187000174 H-loop/switch region; other site 1199187000175 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1199187000176 dimer interface [polypeptide binding]; other site 1199187000177 putative PBP binding regions; other site 1199187000178 ABC-ATPase subunit interface; other site 1199187000179 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187000180 PPE family; Region: PPE; pfam00823 1199187000181 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1199187000182 Condensation domain; Region: Condensation; pfam00668 1199187000183 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1199187000184 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187000185 Zn binding site [ion binding]; other site 1199187000186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000187 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187000188 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187000189 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187000190 active site 1199187000191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187000192 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1199187000193 FAD binding site [chemical binding]; other site 1199187000194 substrate binding site [chemical binding]; other site 1199187000195 catalytic base [active] 1199187000196 acyl-CoA synthetase; Validated; Region: PRK07788 1199187000197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187000198 acyl-activating enzyme (AAE) consensus motif; other site 1199187000199 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187000200 active site 1199187000201 CoA binding site [chemical binding]; other site 1199187000202 AMP binding site [chemical binding]; other site 1199187000203 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 1199187000204 nucleotide binding site [chemical binding]; other site 1199187000205 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1199187000206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187000207 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1199187000208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000209 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1199187000210 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1199187000211 intersubunit interface [polypeptide binding]; other site 1199187000212 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1199187000213 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1199187000214 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1199187000215 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1199187000216 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1199187000217 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1199187000218 active site 1199187000219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1199187000220 DNA binding site [nucleotide binding] 1199187000221 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1199187000222 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1199187000223 putative active site [active] 1199187000224 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1199187000225 putative active site [active] 1199187000226 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1199187000227 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1199187000228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187000229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187000230 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1199187000231 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1199187000232 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1199187000233 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1199187000234 putative dimer interface [polypeptide binding]; other site 1199187000235 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1199187000236 L-aspartate oxidase; Provisional; Region: PRK06175 1199187000237 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1199187000238 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1199187000239 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187000240 catalytic loop [active] 1199187000241 iron binding site [ion binding]; other site 1199187000242 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1199187000243 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1199187000244 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1199187000245 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1199187000246 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1199187000247 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1199187000248 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1199187000249 FAD binding site [chemical binding]; other site 1199187000250 substrate binding site [chemical binding]; other site 1199187000251 catalytic residues [active] 1199187000252 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1199187000253 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1199187000254 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187000255 dimer interface [polypeptide binding]; other site 1199187000256 active site 1199187000257 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1199187000258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187000259 NAD(P) binding site [chemical binding]; other site 1199187000260 active site 1199187000261 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1199187000262 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1199187000263 active site 2 [active] 1199187000264 active site 1 [active] 1199187000265 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1199187000266 putative ion selectivity filter; other site 1199187000267 putative pore gating glutamate residue; other site 1199187000268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000270 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1199187000271 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1199187000272 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1199187000273 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1199187000274 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1199187000275 Lipase maturation factor; Region: LMF1; pfam06762 1199187000276 choline dehydrogenase; Validated; Region: PRK02106 1199187000277 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1199187000278 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1199187000279 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1199187000280 heme binding pocket [chemical binding]; other site 1199187000281 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1199187000282 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1199187000283 heme binding pocket [chemical binding]; other site 1199187000284 formate dehydrogenase; Provisional; Region: PRK07574 1199187000285 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1199187000286 NAD binding site [chemical binding]; other site 1199187000287 Predicted membrane protein [Function unknown]; Region: COG4129 1199187000288 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1199187000289 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187000290 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1199187000291 active site 1199187000292 metal binding site [ion binding]; metal-binding site 1199187000293 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1199187000294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1199187000295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1199187000296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1199187000297 dimerization interface [polypeptide binding]; other site 1199187000298 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1199187000299 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1199187000300 NAD(P) binding site [chemical binding]; other site 1199187000301 catalytic residues [active] 1199187000302 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1199187000303 active site 1199187000304 diiron metal binding site [ion binding]; other site 1199187000305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000307 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1199187000308 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187000309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187000310 Integrase core domain; Region: rve; pfam00665 1199187000311 Integrase core domain; Region: rve_3; pfam13683 1199187000312 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187000313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187000314 active site 1199187000315 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1199187000316 active site 1199187000317 substrate binding pocket [chemical binding]; other site 1199187000318 homodimer interaction site [polypeptide binding]; other site 1199187000319 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187000320 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1199187000321 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1199187000322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187000323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187000324 S-adenosylmethionine binding site [chemical binding]; other site 1199187000325 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1199187000326 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1199187000327 NAD binding site [chemical binding]; other site 1199187000328 catalytic residues [active] 1199187000329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000331 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1199187000332 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187000333 acyl-activating enzyme (AAE) consensus motif; other site 1199187000334 AMP binding site [chemical binding]; other site 1199187000335 active site 1199187000336 CoA binding site [chemical binding]; other site 1199187000337 enoyl-CoA hydratase; Provisional; Region: PRK08252 1199187000338 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187000339 substrate binding site [chemical binding]; other site 1199187000340 oxyanion hole (OAH) forming residues; other site 1199187000341 trimer interface [polypeptide binding]; other site 1199187000342 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1199187000343 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187000344 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187000345 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187000346 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187000347 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187000348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187000349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187000350 active site 1199187000351 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187000352 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1199187000353 active site 2 [active] 1199187000354 active site 1 [active] 1199187000355 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1199187000356 putative active site [active] 1199187000357 putative catalytic site [active] 1199187000358 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187000359 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187000360 active site 1199187000361 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187000362 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187000363 substrate binding site [chemical binding]; other site 1199187000364 oxyanion hole (OAH) forming residues; other site 1199187000365 trimer interface [polypeptide binding]; other site 1199187000366 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1199187000367 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187000368 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1199187000369 acyl-activating enzyme (AAE) consensus motif; other site 1199187000370 acyl-activating enzyme (AAE) consensus motif; other site 1199187000371 putative AMP binding site [chemical binding]; other site 1199187000372 putative active site [active] 1199187000373 putative CoA binding site [chemical binding]; other site 1199187000374 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1199187000375 active site 1199187000376 substrate-binding site [chemical binding]; other site 1199187000377 metal-binding site [ion binding] 1199187000378 GTP binding site [chemical binding]; other site 1199187000379 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1199187000380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187000381 S-adenosylmethionine binding site [chemical binding]; other site 1199187000382 LabA_like proteins; Region: LabA_like; cd06167 1199187000383 putative metal binding site [ion binding]; other site 1199187000384 MMPL family; Region: MMPL; pfam03176 1199187000385 MMPL family; Region: MMPL; pfam03176 1199187000386 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1199187000387 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1199187000388 Predicted integral membrane protein [Function unknown]; Region: COG0392 1199187000389 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1199187000390 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1199187000391 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187000392 molybdopterin cofactor binding site; other site 1199187000393 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187000394 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1199187000395 molybdopterin cofactor binding site; other site 1199187000396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000398 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1199187000399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1199187000400 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1199187000401 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1199187000402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187000403 putative substrate translocation pore; other site 1199187000404 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1199187000405 putative homodimer interface [polypeptide binding]; other site 1199187000406 putative homotetramer interface [polypeptide binding]; other site 1199187000407 putative allosteric switch controlling residues; other site 1199187000408 putative metal binding site [ion binding]; other site 1199187000409 putative homodimer-homodimer interface [polypeptide binding]; other site 1199187000410 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1199187000411 SPW repeat; Region: SPW; pfam03779 1199187000412 SPW repeat; Region: SPW; pfam03779 1199187000413 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1199187000414 FMN binding site [chemical binding]; other site 1199187000415 substrate binding site [chemical binding]; other site 1199187000416 putative catalytic residue [active] 1199187000417 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1199187000418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187000419 S-adenosylmethionine binding site [chemical binding]; other site 1199187000420 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1199187000421 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1199187000422 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1199187000423 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1199187000424 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1199187000425 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1199187000426 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1199187000427 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187000428 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1199187000429 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187000430 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187000431 DNA binding residues [nucleotide binding] 1199187000432 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187000433 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1199187000434 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187000435 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1199187000436 Bacterial transcriptional regulator; Region: IclR; pfam01614 1199187000437 Pirin; Region: Pirin; pfam02678 1199187000438 Pirin-related protein [General function prediction only]; Region: COG1741 1199187000439 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1199187000440 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1199187000441 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1199187000442 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1199187000443 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1199187000444 RDD family; Region: RDD; pfam06271 1199187000445 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187000446 mce related protein; Region: MCE; pfam02470 1199187000447 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187000448 mce related protein; Region: MCE; pfam02470 1199187000449 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187000450 mce related protein; Region: MCE; pfam02470 1199187000451 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187000452 mce related protein; Region: MCE; pfam02470 1199187000453 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1199187000454 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187000455 mce related protein; Region: MCE; pfam02470 1199187000456 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187000457 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187000458 mce related protein; Region: MCE; pfam02470 1199187000459 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187000460 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187000461 Permease; Region: Permease; pfam02405 1199187000462 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187000463 Permease; Region: Permease; pfam02405 1199187000464 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1199187000465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187000466 DNA-binding site [nucleotide binding]; DNA binding site 1199187000467 FCD domain; Region: FCD; pfam07729 1199187000468 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1199187000469 putative hydrophobic ligand binding site [chemical binding]; other site 1199187000470 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1199187000471 active site 1199187000472 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1199187000473 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1199187000474 NAD(P) binding site [chemical binding]; other site 1199187000475 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187000476 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187000477 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187000478 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187000479 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1199187000480 classical (c) SDRs; Region: SDR_c; cd05233 1199187000481 NAD(P) binding site [chemical binding]; other site 1199187000482 active site 1199187000483 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1199187000484 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 1199187000485 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1199187000486 putative NAD(P) binding site [chemical binding]; other site 1199187000487 catalytic Zn binding site [ion binding]; other site 1199187000488 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187000489 Cytochrome P450; Region: p450; cl12078 1199187000490 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187000491 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187000492 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1199187000493 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187000494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187000495 active site 1199187000496 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187000497 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1199187000498 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1199187000499 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1199187000500 active site 1199187000501 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1199187000502 catalytic triad [active] 1199187000503 dimer interface [polypeptide binding]; other site 1199187000504 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1199187000505 hydrophobic ligand binding site; other site 1199187000506 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1199187000507 Strictosidine synthase; Region: Str_synth; pfam03088 1199187000508 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1199187000509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000511 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1199187000512 FAD binding domain; Region: FAD_binding_4; pfam01565 1199187000513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187000514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187000515 NAD(P) binding site [chemical binding]; other site 1199187000516 active site 1199187000517 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187000518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000520 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1199187000521 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1199187000522 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1199187000523 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1199187000524 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1199187000525 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1199187000526 ligand binding site [chemical binding]; other site 1199187000527 homodimer interface [polypeptide binding]; other site 1199187000528 NAD(P) binding site [chemical binding]; other site 1199187000529 trimer interface B [polypeptide binding]; other site 1199187000530 trimer interface A [polypeptide binding]; other site 1199187000531 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187000532 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187000533 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187000534 active site 1199187000535 short chain dehydrogenase; Provisional; Region: PRK07791 1199187000536 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1199187000537 NAD binding site [chemical binding]; other site 1199187000538 homodimer interface [polypeptide binding]; other site 1199187000539 active site 1199187000540 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1199187000541 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1199187000542 NAD(P) binding site [chemical binding]; other site 1199187000543 catalytic residues [active] 1199187000544 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1199187000545 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1199187000546 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187000547 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187000548 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187000549 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187000550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000552 Pirin-related protein [General function prediction only]; Region: COG1741 1199187000553 Pirin; Region: Pirin; pfam02678 1199187000554 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1199187000555 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1199187000556 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1199187000557 dimerization interface [polypeptide binding]; other site 1199187000558 DPS ferroxidase diiron center [ion binding]; other site 1199187000559 ion pore; other site 1199187000560 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1199187000561 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1199187000562 minor groove reading motif; other site 1199187000563 helix-hairpin-helix signature motif; other site 1199187000564 active site 1199187000565 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1199187000566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1199187000567 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1199187000568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187000569 NAD(P) binding site [chemical binding]; other site 1199187000570 active site 1199187000571 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187000572 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1199187000573 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187000574 Cytochrome P450; Region: p450; cl12078 1199187000575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000577 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1199187000578 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187000579 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1199187000580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187000581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000582 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1199187000583 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1199187000584 putative di-iron ligands [ion binding]; other site 1199187000585 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1199187000586 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1199187000587 FAD binding pocket [chemical binding]; other site 1199187000588 FAD binding motif [chemical binding]; other site 1199187000589 phosphate binding motif [ion binding]; other site 1199187000590 beta-alpha-beta structure motif; other site 1199187000591 NAD binding pocket [chemical binding]; other site 1199187000592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187000593 catalytic loop [active] 1199187000594 iron binding site [ion binding]; other site 1199187000595 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1199187000596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187000597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1199187000598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1199187000599 Coenzyme A binding pocket [chemical binding]; other site 1199187000600 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1199187000601 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187000602 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187000603 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1199187000604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187000605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187000606 active site 1199187000607 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1199187000608 putative active site [active] 1199187000609 putative catalytic site [active] 1199187000610 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187000611 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187000612 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1199187000613 TAP-like protein; Region: Abhydrolase_4; pfam08386 1199187000614 Domain of unknown function DUF302; Region: DUF302; pfam03625 1199187000615 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1199187000616 putative homodimer interface [polypeptide binding]; other site 1199187000617 putative homotetramer interface [polypeptide binding]; other site 1199187000618 putative allosteric switch controlling residues; other site 1199187000619 putative metal binding site [ion binding]; other site 1199187000620 putative homodimer-homodimer interface [polypeptide binding]; other site 1199187000621 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1199187000622 active site 1199187000623 metal binding site [ion binding]; metal-binding site 1199187000624 homotetramer interface [polypeptide binding]; other site 1199187000625 MarR family; Region: MarR_2; pfam12802 1199187000626 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1199187000627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187000628 Walker A/P-loop; other site 1199187000629 ATP binding site [chemical binding]; other site 1199187000630 Q-loop/lid; other site 1199187000631 ABC transporter signature motif; other site 1199187000632 Walker B; other site 1199187000633 D-loop; other site 1199187000634 H-loop/switch region; other site 1199187000635 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1199187000636 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1199187000637 Putative esterase; Region: Esterase; pfam00756 1199187000638 Predicted membrane protein [Function unknown]; Region: COG3619 1199187000639 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1199187000640 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1199187000641 trehalose synthase; Region: treS_nterm; TIGR02456 1199187000642 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1199187000643 active site 1199187000644 catalytic site [active] 1199187000645 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1199187000646 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1199187000647 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1199187000648 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1199187000649 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1199187000650 elongation factor G; Reviewed; Region: PRK12740 1199187000651 G1 box; other site 1199187000652 putative GEF interaction site [polypeptide binding]; other site 1199187000653 GTP/Mg2+ binding site [chemical binding]; other site 1199187000654 Switch I region; other site 1199187000655 G2 box; other site 1199187000656 G3 box; other site 1199187000657 Switch II region; other site 1199187000658 G4 box; other site 1199187000659 G5 box; other site 1199187000660 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1199187000661 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1199187000662 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1199187000663 acyl-CoA synthetase; Validated; Region: PRK05852 1199187000664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187000665 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1199187000666 acyl-activating enzyme (AAE) consensus motif; other site 1199187000667 acyl-activating enzyme (AAE) consensus motif; other site 1199187000668 putative AMP binding site [chemical binding]; other site 1199187000669 putative active site [active] 1199187000670 putative CoA binding site [chemical binding]; other site 1199187000671 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1199187000672 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1199187000673 PYR/PP interface [polypeptide binding]; other site 1199187000674 dimer interface [polypeptide binding]; other site 1199187000675 TPP binding site [chemical binding]; other site 1199187000676 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1199187000677 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1199187000678 TPP-binding site; other site 1199187000679 dimer interface [polypeptide binding]; other site 1199187000680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1199187000681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1199187000682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1199187000683 dimerization interface [polypeptide binding]; other site 1199187000684 Isochorismatase family; Region: Isochorismatase; pfam00857 1199187000685 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1199187000686 catalytic triad [active] 1199187000687 conserved cis-peptide bond; other site 1199187000688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1199187000689 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1199187000690 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1199187000691 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1199187000692 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1199187000693 putative NAD(P) binding site [chemical binding]; other site 1199187000694 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1199187000695 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1199187000696 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1199187000697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187000698 S-adenosylmethionine binding site [chemical binding]; other site 1199187000699 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187000700 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1199187000701 active site 1199187000702 catalytic triad [active] 1199187000703 oxyanion hole [active] 1199187000704 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1199187000705 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1199187000706 NAD binding site [chemical binding]; other site 1199187000707 catalytic residues [active] 1199187000708 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1199187000709 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1199187000710 PYR/PP interface [polypeptide binding]; other site 1199187000711 dimer interface [polypeptide binding]; other site 1199187000712 TPP binding site [chemical binding]; other site 1199187000713 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1199187000714 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1199187000715 TPP-binding site; other site 1199187000716 dimer interface [polypeptide binding]; other site 1199187000717 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187000718 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187000719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187000720 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187000721 NAD(P) binding site [chemical binding]; other site 1199187000722 active site 1199187000723 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187000724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187000725 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187000726 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187000727 [2Fe-2S] cluster binding site [ion binding]; other site 1199187000728 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1199187000729 putative alpha subunit interface [polypeptide binding]; other site 1199187000730 putative active site [active] 1199187000731 putative substrate binding site [chemical binding]; other site 1199187000732 Fe binding site [ion binding]; other site 1199187000733 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1199187000734 classical (c) SDRs; Region: SDR_c; cd05233 1199187000735 NAD(P) binding site [chemical binding]; other site 1199187000736 active site 1199187000737 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1199187000738 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1199187000739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187000740 DNA-binding site [nucleotide binding]; DNA binding site 1199187000741 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1199187000742 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1199187000743 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1199187000744 acyl-activating enzyme (AAE) consensus motif; other site 1199187000745 putative AMP binding site [chemical binding]; other site 1199187000746 putative active site [active] 1199187000747 putative CoA binding site [chemical binding]; other site 1199187000748 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1199187000749 classical (c) SDRs; Region: SDR_c; cd05233 1199187000750 NAD(P) binding site [chemical binding]; other site 1199187000751 active site 1199187000752 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1199187000753 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1199187000754 NAD binding site [chemical binding]; other site 1199187000755 catalytic Zn binding site [ion binding]; other site 1199187000756 substrate binding site [chemical binding]; other site 1199187000757 structural Zn binding site [ion binding]; other site 1199187000758 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1199187000759 hydrophobic ligand binding site; other site 1199187000760 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187000761 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1199187000762 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1199187000763 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1199187000764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187000765 motif II; other site 1199187000766 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1199187000767 acyl-CoA synthetase; Provisional; Region: PRK13383 1199187000768 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187000769 acyl-activating enzyme (AAE) consensus motif; other site 1199187000770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187000771 AMP binding site [chemical binding]; other site 1199187000772 active site 1199187000773 acyl-activating enzyme (AAE) consensus motif; other site 1199187000774 CoA binding site [chemical binding]; other site 1199187000775 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1199187000776 classical (c) SDRs; Region: SDR_c; cd05233 1199187000777 NAD(P) binding site [chemical binding]; other site 1199187000778 active site 1199187000779 Cutinase; Region: Cutinase; pfam01083 1199187000780 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1199187000781 NAD(P) binding site [chemical binding]; other site 1199187000782 catalytic residues [active] 1199187000783 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1199187000784 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1199187000785 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1199187000786 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1199187000787 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1199187000788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187000789 motif II; other site 1199187000790 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187000791 PPE family; Region: PPE; pfam00823 1199187000792 GMP synthase; Reviewed; Region: guaA; PRK00074 1199187000793 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1199187000794 AMP/PPi binding site [chemical binding]; other site 1199187000795 candidate oxyanion hole; other site 1199187000796 catalytic triad [active] 1199187000797 potential glutamine specificity residues [chemical binding]; other site 1199187000798 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1199187000799 ATP Binding subdomain [chemical binding]; other site 1199187000800 Ligand Binding sites [chemical binding]; other site 1199187000801 Dimerization subdomain; other site 1199187000802 Y-family of DNA polymerases; Region: PolY; cl12025 1199187000803 DNA binding site [nucleotide binding] 1199187000804 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1199187000805 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1199187000806 putative active site [active] 1199187000807 putative substrate binding site [chemical binding]; other site 1199187000808 putative FMN binding site [chemical binding]; other site 1199187000809 putative catalytic residues [active] 1199187000810 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1199187000811 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1199187000812 dimer interface [polypeptide binding]; other site 1199187000813 active site 1199187000814 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1199187000815 active site 1199187000816 Biofilm formation and stress response factor; Region: BsmA; cl01794 1199187000817 short chain dehydrogenase; Provisional; Region: PRK07201 1199187000818 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1199187000819 putative NAD(P) binding site [chemical binding]; other site 1199187000820 active site 1199187000821 putative substrate binding site [chemical binding]; other site 1199187000822 classical (c) SDRs; Region: SDR_c; cd05233 1199187000823 NAD(P) binding site [chemical binding]; other site 1199187000824 active site 1199187000825 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187000826 catalytic core [active] 1199187000827 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187000828 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187000829 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1199187000830 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1199187000831 dimer interaction site [polypeptide binding]; other site 1199187000832 substrate-binding tunnel; other site 1199187000833 active site 1199187000834 catalytic site [active] 1199187000835 substrate binding site [chemical binding]; other site 1199187000836 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1199187000837 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1199187000838 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187000839 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1199187000840 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1199187000841 active site 1199187000842 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1199187000843 generic binding surface II; other site 1199187000844 generic binding surface I; other site 1199187000845 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1199187000846 FMN binding site [chemical binding]; other site 1199187000847 dimer interface [polypeptide binding]; other site 1199187000848 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1199187000849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187000850 S-adenosylmethionine binding site [chemical binding]; other site 1199187000851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187000852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187000853 ATP binding site [chemical binding]; other site 1199187000854 Mg2+ binding site [ion binding]; other site 1199187000855 G-X-G motif; other site 1199187000856 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1199187000857 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1199187000858 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1199187000859 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1199187000860 G1 box; other site 1199187000861 GTP/Mg2+ binding site [chemical binding]; other site 1199187000862 G2 box; other site 1199187000863 Switch I region; other site 1199187000864 G3 box; other site 1199187000865 Switch II region; other site 1199187000866 G4 box; other site 1199187000867 G5 box; other site 1199187000868 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1199187000869 Transposase domain (DUF772); Region: DUF772; pfam05598 1199187000870 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187000871 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187000872 phosphopeptide binding site; other site 1199187000873 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187000874 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187000875 phosphopeptide binding site; other site 1199187000876 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1199187000877 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1199187000878 Walker A/P-loop; other site 1199187000879 ATP binding site [chemical binding]; other site 1199187000880 Q-loop/lid; other site 1199187000881 ABC transporter signature motif; other site 1199187000882 Walker B; other site 1199187000883 D-loop; other site 1199187000884 H-loop/switch region; other site 1199187000885 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1199187000886 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187000887 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187000888 phosphopeptide binding site; other site 1199187000889 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187000890 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187000891 phosphopeptide binding site; other site 1199187000892 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1199187000893 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1199187000894 Walker A/P-loop; other site 1199187000895 ATP binding site [chemical binding]; other site 1199187000896 Q-loop/lid; other site 1199187000897 ABC transporter signature motif; other site 1199187000898 Walker B; other site 1199187000899 D-loop; other site 1199187000900 H-loop/switch region; other site 1199187000901 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1199187000902 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1199187000903 active site 1199187000904 FMN binding site [chemical binding]; other site 1199187000905 substrate binding site [chemical binding]; other site 1199187000906 putative catalytic residue [active] 1199187000907 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1199187000908 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1199187000909 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1199187000910 homodimer interface [polypeptide binding]; other site 1199187000911 NADP binding site [chemical binding]; other site 1199187000912 substrate binding site [chemical binding]; other site 1199187000913 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1199187000914 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187000915 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187000916 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187000917 active site 1199187000918 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1199187000919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187000920 S-adenosylmethionine binding site [chemical binding]; other site 1199187000921 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1199187000922 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1199187000923 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1199187000924 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1199187000925 homodimer interface [polypeptide binding]; other site 1199187000926 substrate-cofactor binding pocket; other site 1199187000927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187000928 catalytic residue [active] 1199187000929 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1199187000930 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1199187000931 isocitrate dehydrogenase; Validated; Region: PRK08299 1199187000932 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187000933 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1199187000934 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1199187000935 active site 1199187000936 HIGH motif; other site 1199187000937 dimer interface [polypeptide binding]; other site 1199187000938 KMSKS motif; other site 1199187000939 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1199187000940 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1199187000941 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1199187000942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187000943 putative substrate translocation pore; other site 1199187000944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187000945 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1199187000946 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1199187000947 hypothetical protein; Provisional; Region: PRK06541 1199187000948 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1199187000949 inhibitor-cofactor binding pocket; inhibition site 1199187000950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187000951 catalytic residue [active] 1199187000952 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1199187000953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187000954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187000955 DNA binding residues [nucleotide binding] 1199187000956 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1199187000957 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187000958 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1199187000959 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1199187000960 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1199187000961 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1199187000962 L-aspartate oxidase; Provisional; Region: PRK06175 1199187000963 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1199187000964 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1199187000965 putative Iron-sulfur protein interface [polypeptide binding]; other site 1199187000966 putative proximal heme binding site [chemical binding]; other site 1199187000967 putative SdhC-like subunit interface [polypeptide binding]; other site 1199187000968 putative distal heme binding site [chemical binding]; other site 1199187000969 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1199187000970 putative Iron-sulfur protein interface [polypeptide binding]; other site 1199187000971 putative proximal heme binding site [chemical binding]; other site 1199187000972 putative SdhD-like interface [polypeptide binding]; other site 1199187000973 putative distal heme binding site [chemical binding]; other site 1199187000974 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1199187000975 active site 1199187000976 catalytic motif [active] 1199187000977 Zn binding site [ion binding]; other site 1199187000978 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1199187000979 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1199187000980 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1199187000981 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1199187000982 adenosine deaminase; Provisional; Region: PRK09358 1199187000983 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1199187000984 active site 1199187000985 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1199187000986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187000987 non-specific DNA binding site [nucleotide binding]; other site 1199187000988 salt bridge; other site 1199187000989 sequence-specific DNA binding site [nucleotide binding]; other site 1199187000990 hypothetical protein; Provisional; Region: PRK13685 1199187000991 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1199187000992 metal ion-dependent adhesion site (MIDAS); other site 1199187000993 hypothetical protein; Provisional; Region: PRK13685 1199187000994 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1199187000995 metal ion-dependent adhesion site (MIDAS); other site 1199187000996 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1199187000997 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1199187000998 active site 1199187000999 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1199187001000 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1199187001001 active site 1199187001002 substrate binding site [chemical binding]; other site 1199187001003 metal binding site [ion binding]; metal-binding site 1199187001004 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1199187001005 Cutinase; Region: Cutinase; pfam01083 1199187001006 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1199187001007 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1199187001008 amidohydrolase; Region: amidohydrolases; TIGR01891 1199187001009 metal binding site [ion binding]; metal-binding site 1199187001010 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1199187001011 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1199187001012 metal binding site [ion binding]; metal-binding site 1199187001013 putative dimer interface [polypeptide binding]; other site 1199187001014 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1199187001015 putative active site pocket [active] 1199187001016 dimerization interface [polypeptide binding]; other site 1199187001017 putative catalytic residue [active] 1199187001018 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1199187001019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187001020 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187001021 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1199187001022 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1199187001023 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1199187001024 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1199187001025 active site 1199187001026 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187001027 PPE family; Region: PPE; pfam00823 1199187001028 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187001029 PPE family; Region: PPE; pfam00823 1199187001030 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187001031 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1199187001032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187001033 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1199187001034 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1199187001035 putative DNA binding site [nucleotide binding]; other site 1199187001036 catalytic residue [active] 1199187001037 putative H2TH interface [polypeptide binding]; other site 1199187001038 putative catalytic residues [active] 1199187001039 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1199187001040 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1199187001041 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187001042 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1199187001043 ATP binding site [chemical binding]; other site 1199187001044 putative Mg++ binding site [ion binding]; other site 1199187001045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187001046 nucleotide binding region [chemical binding]; other site 1199187001047 ATP-binding site [chemical binding]; other site 1199187001048 DEAD/H associated; Region: DEAD_assoc; pfam08494 1199187001049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001051 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1199187001052 aldehyde dehydrogenase family 7 member; Region: PLN02315 1199187001053 tetrameric interface [polypeptide binding]; other site 1199187001054 NAD binding site [chemical binding]; other site 1199187001055 catalytic residues [active] 1199187001056 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1199187001057 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1199187001058 AsnC family; Region: AsnC_trans_reg; pfam01037 1199187001059 L-lysine aminotransferase; Provisional; Region: PRK08297 1199187001060 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1199187001061 inhibitor-cofactor binding pocket; inhibition site 1199187001062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187001063 catalytic residue [active] 1199187001064 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1199187001065 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1199187001066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187001067 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1199187001068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187001069 DNA binding residues [nucleotide binding] 1199187001070 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187001071 anti sigma factor interaction site; other site 1199187001072 regulatory phosphorylation site [posttranslational modification]; other site 1199187001073 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1199187001074 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1199187001075 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1199187001076 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1199187001077 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1199187001078 carboxyltransferase (CT) interaction site; other site 1199187001079 biotinylation site [posttranslational modification]; other site 1199187001080 Fe-S metabolism associated domain; Region: SufE; cl00951 1199187001081 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1199187001082 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1199187001083 active site residue [active] 1199187001084 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1199187001085 active site residue [active] 1199187001086 Maf-like protein; Region: Maf; pfam02545 1199187001087 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1199187001088 active site 1199187001089 dimer interface [polypeptide binding]; other site 1199187001090 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1199187001091 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1199187001092 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1199187001093 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1199187001094 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1199187001095 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1199187001096 biotin--protein ligase; Provisional; Region: PRK06955 1199187001097 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1199187001098 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1199187001099 Bacterial PH domain; Region: DUF304; pfam03703 1199187001100 Predicted membrane protein [Function unknown]; Region: COG2246 1199187001101 GtrA-like protein; Region: GtrA; pfam04138 1199187001102 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1199187001103 ATP-grasp domain; Region: ATP-grasp; pfam02222 1199187001104 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1199187001105 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187001106 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1199187001107 FAD binding site [chemical binding]; other site 1199187001108 homotetramer interface [polypeptide binding]; other site 1199187001109 substrate binding pocket [chemical binding]; other site 1199187001110 catalytic base [active] 1199187001111 CHASE3 domain; Region: CHASE3; pfam05227 1199187001112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187001113 HAMP domain; Region: HAMP; pfam00672 1199187001114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187001115 dimer interface [polypeptide binding]; other site 1199187001116 phosphorylation site [posttranslational modification] 1199187001117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187001118 ATP binding site [chemical binding]; other site 1199187001119 Mg2+ binding site [ion binding]; other site 1199187001120 G-X-G motif; other site 1199187001121 Response regulator receiver domain; Region: Response_reg; pfam00072 1199187001122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187001123 active site 1199187001124 phosphorylation site [posttranslational modification] 1199187001125 intermolecular recognition site; other site 1199187001126 dimerization interface [polypeptide binding]; other site 1199187001127 PBP superfamily domain; Region: PBP_like_2; cl17296 1199187001128 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1199187001129 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1199187001130 active site 1199187001131 ATP binding site [chemical binding]; other site 1199187001132 substrate binding site [chemical binding]; other site 1199187001133 activation loop (A-loop); other site 1199187001134 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1199187001135 NHL repeat; Region: NHL; pfam01436 1199187001136 NHL repeat; Region: NHL; pfam01436 1199187001137 NHL repeat; Region: NHL; pfam01436 1199187001138 NHL repeat; Region: NHL; pfam01436 1199187001139 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187001140 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187001141 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187001142 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187001143 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1199187001144 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1199187001145 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1199187001146 TIGR03089 family protein; Region: TIGR03089 1199187001147 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1199187001148 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1199187001149 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1199187001150 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1199187001151 NADP binding site [chemical binding]; other site 1199187001152 active site 1199187001153 putative substrate binding site [chemical binding]; other site 1199187001154 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1199187001155 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1199187001156 Probable Catalytic site; other site 1199187001157 metal-binding site 1199187001158 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1199187001159 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1199187001160 active site 1199187001161 Substrate binding site; other site 1199187001162 Mg++ binding site; other site 1199187001163 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1199187001164 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1199187001165 nudix motif; other site 1199187001166 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1199187001167 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1199187001168 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1199187001169 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1199187001170 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 1199187001171 FMN binding site [chemical binding]; other site 1199187001172 dimer interface [polypeptide binding]; other site 1199187001173 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1199187001174 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1199187001175 phosphate binding site [ion binding]; other site 1199187001176 dimer interface [polypeptide binding]; other site 1199187001177 Transcription factor WhiB; Region: Whib; pfam02467 1199187001178 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1199187001179 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1199187001180 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1199187001181 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1199187001182 active site 1199187001183 substrate binding site [chemical binding]; other site 1199187001184 metal binding site [ion binding]; metal-binding site 1199187001185 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1199187001186 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1199187001187 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1199187001188 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1199187001189 amino acid transporter; Region: 2A0306; TIGR00909 1199187001190 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1199187001191 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1199187001192 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1199187001193 Di-iron ligands [ion binding]; other site 1199187001194 Rubredoxin [Energy production and conversion]; Region: COG1773 1199187001195 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1199187001196 iron binding site [ion binding]; other site 1199187001197 Rubredoxin [Energy production and conversion]; Region: COG1773 1199187001198 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1199187001199 iron binding site [ion binding]; other site 1199187001200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001202 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1199187001203 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1199187001204 homotetramer interface [polypeptide binding]; other site 1199187001205 ligand binding site [chemical binding]; other site 1199187001206 catalytic site [active] 1199187001207 NAD binding site [chemical binding]; other site 1199187001208 thymidylate kinase; Validated; Region: PRK07933 1199187001209 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1199187001210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187001211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187001212 active site 1199187001213 phosphorylation site [posttranslational modification] 1199187001214 intermolecular recognition site; other site 1199187001215 dimerization interface [polypeptide binding]; other site 1199187001216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187001217 DNA binding site [nucleotide binding] 1199187001218 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1199187001219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187001220 dimerization interface [polypeptide binding]; other site 1199187001221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187001222 dimer interface [polypeptide binding]; other site 1199187001223 phosphorylation site [posttranslational modification] 1199187001224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187001225 ATP binding site [chemical binding]; other site 1199187001226 Mg2+ binding site [ion binding]; other site 1199187001227 G-X-G motif; other site 1199187001228 lipoprotein LpqB; Provisional; Region: PRK13616 1199187001229 Sporulation and spore germination; Region: Germane; pfam10646 1199187001230 Transposase domain (DUF772); Region: DUF772; pfam05598 1199187001231 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1199187001232 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1199187001233 30S subunit binding site; other site 1199187001234 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1199187001235 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1199187001236 HD domain; Region: HD_5; pfam13487 1199187001237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1199187001238 Zn2+ binding site [ion binding]; other site 1199187001239 Mg2+ binding site [ion binding]; other site 1199187001240 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1199187001241 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1199187001242 DNA binding residues [nucleotide binding] 1199187001243 dimerization interface [polypeptide binding]; other site 1199187001244 Phospholipid methyltransferase; Region: PEMT; cl17370 1199187001245 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1199187001246 TrkA-C domain; Region: TrkA_C; pfam02080 1199187001247 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1199187001248 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1199187001249 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1199187001250 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187001251 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1199187001252 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1199187001253 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1199187001254 FAD binding pocket [chemical binding]; other site 1199187001255 FAD binding motif [chemical binding]; other site 1199187001256 phosphate binding motif [ion binding]; other site 1199187001257 beta-alpha-beta structure motif; other site 1199187001258 NAD binding pocket [chemical binding]; other site 1199187001259 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187001260 catalytic loop [active] 1199187001261 iron binding site [ion binding]; other site 1199187001262 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1199187001263 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1199187001264 putative di-iron ligands [ion binding]; other site 1199187001265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001266 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1199187001267 DNA-binding interface [nucleotide binding]; DNA binding site 1199187001268 Domain of unknown function DUF302; Region: DUF302; pfam03625 1199187001269 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1199187001270 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187001271 dimer interface [polypeptide binding]; other site 1199187001272 active site 1199187001273 Predicted transcriptional regulators [Transcription]; Region: COG1733 1199187001274 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1199187001275 Predicted GTPases [General function prediction only]; Region: COG1162 1199187001276 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1199187001277 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1199187001278 GTP/Mg2+ binding site [chemical binding]; other site 1199187001279 G4 box; other site 1199187001280 G5 box; other site 1199187001281 G1 box; other site 1199187001282 Switch I region; other site 1199187001283 G2 box; other site 1199187001284 G3 box; other site 1199187001285 Switch II region; other site 1199187001286 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1199187001287 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1199187001288 hinge; other site 1199187001289 active site 1199187001290 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1199187001291 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187001292 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187001293 active site 1199187001294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001296 classical (c) SDRs; Region: SDR_c; cd05233 1199187001297 NAD(P) binding site [chemical binding]; other site 1199187001298 active site 1199187001299 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187001300 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1199187001301 classical (c) SDRs; Region: SDR_c; cd05233 1199187001302 NAD(P) binding site [chemical binding]; other site 1199187001303 active site 1199187001304 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1199187001305 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1199187001306 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1199187001307 NAD(P) binding site [chemical binding]; other site 1199187001308 short chain dehydrogenase; Provisional; Region: PRK08278 1199187001309 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1199187001310 NAD(P) binding site [chemical binding]; other site 1199187001311 homodimer interface [polypeptide binding]; other site 1199187001312 active site 1199187001313 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1199187001314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187001315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187001316 DNA binding residues [nucleotide binding] 1199187001317 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1199187001318 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1199187001319 carboxyltransferase (CT) interaction site; other site 1199187001320 biotinylation site [posttranslational modification]; other site 1199187001321 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1199187001322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1199187001323 Histidine kinase; Region: HisKA_2; pfam07568 1199187001324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187001325 ATP binding site [chemical binding]; other site 1199187001326 Mg2+ binding site [ion binding]; other site 1199187001327 G-X-G motif; other site 1199187001328 Transcription factor WhiB; Region: Whib; pfam02467 1199187001329 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1199187001330 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1199187001331 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1199187001332 isochorismate synthase DhbC; Validated; Region: PRK06923 1199187001333 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1199187001334 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187001335 catalytic core [active] 1199187001336 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1199187001337 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1199187001338 P-loop; other site 1199187001339 Magnesium ion binding site [ion binding]; other site 1199187001340 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1199187001341 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1199187001342 Magnesium ion binding site [ion binding]; other site 1199187001343 helicase 45; Provisional; Region: PTZ00424 1199187001344 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1199187001345 ATP binding site [chemical binding]; other site 1199187001346 Mg++ binding site [ion binding]; other site 1199187001347 motif III; other site 1199187001348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187001349 nucleotide binding region [chemical binding]; other site 1199187001350 ATP-binding site [chemical binding]; other site 1199187001351 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1199187001352 dinuclear metal binding motif [ion binding]; other site 1199187001353 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1199187001354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001356 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1199187001357 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1199187001358 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1199187001359 ATP binding site [chemical binding]; other site 1199187001360 substrate interface [chemical binding]; other site 1199187001361 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1199187001362 active site residue [active] 1199187001363 TIGR02569 family protein; Region: TIGR02569_actnb 1199187001364 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1199187001365 DNA binding site [nucleotide binding] 1199187001366 active site 1199187001367 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187001368 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187001369 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1199187001370 catalytic site [active] 1199187001371 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1199187001372 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1199187001373 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1199187001374 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1199187001375 Part of AAA domain; Region: AAA_19; pfam13245 1199187001376 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1199187001377 Ion channel; Region: Ion_trans_2; pfam07885 1199187001378 TrkA-N domain; Region: TrkA_N; pfam02254 1199187001379 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1199187001380 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1199187001381 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1199187001382 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1199187001383 putative NADH binding site [chemical binding]; other site 1199187001384 putative active site [active] 1199187001385 nudix motif; other site 1199187001386 putative metal binding site [ion binding]; other site 1199187001387 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1199187001388 catalytic residues [active] 1199187001389 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1199187001390 Part of AAA domain; Region: AAA_19; pfam13245 1199187001391 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1199187001392 Family description; Region: UvrD_C_2; pfam13538 1199187001393 HRDC domain; Region: HRDC; pfam00570 1199187001394 Transcription factor WhiB; Region: Whib; pfam02467 1199187001395 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1199187001396 ABC1 family; Region: ABC1; pfam03109 1199187001397 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1199187001398 active site 1199187001399 ATP binding site [chemical binding]; other site 1199187001400 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1199187001401 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1199187001402 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1199187001403 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1199187001404 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1199187001405 hypothetical protein; Validated; Region: PRK00068 1199187001406 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1199187001407 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187001408 mce related protein; Region: MCE; pfam02470 1199187001409 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187001410 short chain dehydrogenase; Provisional; Region: PRK06197 1199187001411 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1199187001412 putative NAD(P) binding site [chemical binding]; other site 1199187001413 active site 1199187001414 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187001415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1199187001416 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187001417 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1199187001418 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1199187001419 acyl-CoA synthetase; Validated; Region: PRK05850 1199187001420 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1199187001421 acyl-activating enzyme (AAE) consensus motif; other site 1199187001422 active site 1199187001423 thioester reductase domain; Region: Thioester-redct; TIGR01746 1199187001424 Male sterility protein; Region: NAD_binding_4; pfam07993 1199187001425 NAD(P) binding site [chemical binding]; other site 1199187001426 active site 1199187001427 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1199187001428 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1199187001429 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187001430 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187001431 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1199187001432 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1199187001433 FMN-binding pocket [chemical binding]; other site 1199187001434 flavin binding motif; other site 1199187001435 phosphate binding motif [ion binding]; other site 1199187001436 beta-alpha-beta structure motif; other site 1199187001437 NAD binding pocket [chemical binding]; other site 1199187001438 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187001439 catalytic loop [active] 1199187001440 iron binding site [ion binding]; other site 1199187001441 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1199187001442 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1199187001443 yiaA/B two helix domain; Region: YiaAB; cl01759 1199187001444 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1199187001445 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1199187001446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187001447 active site 1199187001448 phosphorylation site [posttranslational modification] 1199187001449 intermolecular recognition site; other site 1199187001450 dimerization interface [polypeptide binding]; other site 1199187001451 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1199187001452 DNA binding residues [nucleotide binding] 1199187001453 dimerization interface [polypeptide binding]; other site 1199187001454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1199187001455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187001456 ATP binding site [chemical binding]; other site 1199187001457 Mg2+ binding site [ion binding]; other site 1199187001458 G-X-G motif; other site 1199187001459 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1199187001460 dimer interface [polypeptide binding]; other site 1199187001461 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1199187001462 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1199187001463 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1199187001464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187001465 active site 1199187001466 phosphorylation site [posttranslational modification] 1199187001467 intermolecular recognition site; other site 1199187001468 dimerization interface [polypeptide binding]; other site 1199187001469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1199187001470 DNA binding residues [nucleotide binding] 1199187001471 dimerization interface [polypeptide binding]; other site 1199187001472 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1199187001473 GAF domain; Region: GAF; pfam01590 1199187001474 GAF domain; Region: GAF_3; pfam13492 1199187001475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1199187001476 Histidine kinase; Region: HisKA_3; pfam07730 1199187001477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187001478 ATP binding site [chemical binding]; other site 1199187001479 Mg2+ binding site [ion binding]; other site 1199187001480 G-X-G motif; other site 1199187001481 PAS fold; Region: PAS_3; pfam08447 1199187001482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1199187001483 putative active site [active] 1199187001484 heme pocket [chemical binding]; other site 1199187001485 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1199187001486 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1199187001487 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1199187001488 putative dimer interface [polypeptide binding]; other site 1199187001489 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1199187001490 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1199187001491 DNA binding residues [nucleotide binding] 1199187001492 putative dimer interface [polypeptide binding]; other site 1199187001493 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1199187001494 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1199187001495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187001496 GAF domain; Region: GAF; pfam01590 1199187001497 GAF domain; Region: GAF_2; pfam13185 1199187001498 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1199187001499 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1199187001500 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1199187001501 NAD binding site [chemical binding]; other site 1199187001502 catalytic Zn binding site [ion binding]; other site 1199187001503 structural Zn binding site [ion binding]; other site 1199187001504 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1199187001505 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1199187001506 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1199187001507 active site 1199187001508 catalytic site [active] 1199187001509 classical (c) SDRs; Region: SDR_c; cd05233 1199187001510 NAD(P) binding site [chemical binding]; other site 1199187001511 active site 1199187001512 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187001513 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187001514 active site 1199187001515 catalytic tetrad [active] 1199187001516 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1199187001517 PknH-like extracellular domain; Region: PknH_C; pfam14032 1199187001518 Hemerythrin-like domain; Region: Hr-like; cd12108 1199187001519 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1199187001520 Fe-S cluster binding site [ion binding]; other site 1199187001521 active site 1199187001522 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1199187001523 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1199187001524 PYR/PP interface [polypeptide binding]; other site 1199187001525 dimer interface [polypeptide binding]; other site 1199187001526 tetramer interface [polypeptide binding]; other site 1199187001527 TPP binding site [chemical binding]; other site 1199187001528 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1199187001529 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1199187001530 TPP-binding site [chemical binding]; other site 1199187001531 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1199187001532 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1199187001533 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1199187001534 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1199187001535 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1199187001536 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1199187001537 putative active site [active] 1199187001538 classical (c) SDRs; Region: SDR_c; cd05233 1199187001539 NAD(P) binding site [chemical binding]; other site 1199187001540 active site 1199187001541 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1199187001542 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1199187001543 putative active site [active] 1199187001544 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1199187001545 substrate binding site [chemical binding]; other site 1199187001546 ATP binding site [chemical binding]; other site 1199187001547 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187001548 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1199187001549 active site 1199187001550 nucleotide binding site [chemical binding]; other site 1199187001551 HIGH motif; other site 1199187001552 KMSKS motif; other site 1199187001553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1199187001554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187001555 active site 1199187001556 motif I; other site 1199187001557 motif II; other site 1199187001558 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1199187001559 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1199187001560 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1199187001561 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1199187001562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187001563 NAD(P) binding site [chemical binding]; other site 1199187001564 active site 1199187001565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187001566 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1199187001567 putative ADP-binding pocket [chemical binding]; other site 1199187001568 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187001569 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1199187001570 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1199187001571 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1199187001572 active site 1199187001573 DNA binding site [nucleotide binding] 1199187001574 Int/Topo IB signature motif; other site 1199187001575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187001576 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1199187001577 NAD(P) binding site [chemical binding]; other site 1199187001578 active site 1199187001579 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1199187001580 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1199187001581 putative metal binding site [ion binding]; other site 1199187001582 putative metal binding site [ion binding]; other site 1199187001583 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1199187001584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187001585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187001586 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1199187001587 hydroperoxidase II; Provisional; Region: katE; PRK11249 1199187001588 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1199187001589 tetramer interface [polypeptide binding]; other site 1199187001590 heme binding pocket [chemical binding]; other site 1199187001591 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1199187001592 domain interactions; other site 1199187001593 CheB methylesterase; Region: CheB_methylest; pfam01339 1199187001594 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187001595 anti sigma factor interaction site; other site 1199187001596 regulatory phosphorylation site [posttranslational modification]; other site 1199187001597 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1199187001598 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1199187001599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187001600 S-adenosylmethionine binding site [chemical binding]; other site 1199187001601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1199187001602 PAS domain; Region: PAS_9; pfam13426 1199187001603 putative active site [active] 1199187001604 heme pocket [chemical binding]; other site 1199187001605 PAS domain; Region: PAS; smart00091 1199187001606 PAS domain; Region: PAS_9; pfam13426 1199187001607 putative active site [active] 1199187001608 heme pocket [chemical binding]; other site 1199187001609 CheB methylesterase; Region: CheB_methylest; pfam01339 1199187001610 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1199187001611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187001612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1199187001613 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1199187001614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1199187001615 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187001616 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187001617 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1199187001618 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1199187001619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187001620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187001621 metabolite-proton symporter; Region: 2A0106; TIGR00883 1199187001622 putative substrate translocation pore; other site 1199187001623 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1199187001624 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1199187001625 active site 1199187001626 non-prolyl cis peptide bond; other site 1199187001627 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1199187001628 putative active site [active] 1199187001629 putative substrate binding site [chemical binding]; other site 1199187001630 ATP binding site [chemical binding]; other site 1199187001631 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187001632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001634 short chain dehydrogenase; Provisional; Region: PRK07814 1199187001635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187001636 classical (c) SDRs; Region: SDR_c; cd05233 1199187001637 NAD(P) binding site [chemical binding]; other site 1199187001638 active site 1199187001639 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187001640 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187001641 active site 1199187001642 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1199187001643 MoxR-like ATPases [General function prediction only]; Region: COG0714 1199187001644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187001645 Walker A motif; other site 1199187001646 ATP binding site [chemical binding]; other site 1199187001647 Walker B motif; other site 1199187001648 arginine finger; other site 1199187001649 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1199187001650 Protein of unknown function DUF58; Region: DUF58; pfam01882 1199187001651 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187001652 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1199187001653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001654 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1199187001655 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1199187001656 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1199187001657 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1199187001658 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1199187001659 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1199187001660 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1199187001661 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 1199187001662 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1199187001663 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1199187001664 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1199187001665 4Fe-4S binding domain; Region: Fer4; pfam00037 1199187001666 4Fe-4S binding domain; Region: Fer4; pfam00037 1199187001667 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1199187001668 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1199187001669 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1199187001670 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187001671 catalytic loop [active] 1199187001672 iron binding site [ion binding]; other site 1199187001673 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1199187001674 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187001675 molybdopterin cofactor binding site; other site 1199187001676 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1199187001677 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1199187001678 SLBB domain; Region: SLBB; pfam10531 1199187001679 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1199187001680 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1199187001681 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1199187001682 putative dimer interface [polypeptide binding]; other site 1199187001683 [2Fe-2S] cluster binding site [ion binding]; other site 1199187001684 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1199187001685 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1199187001686 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1199187001687 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1199187001688 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1199187001689 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1199187001690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1199187001691 phosphorylation site [posttranslational modification] 1199187001692 intermolecular recognition site; other site 1199187001693 YceI-like domain; Region: YceI; pfam04264 1199187001694 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1199187001695 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1199187001696 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187001697 putative active site [active] 1199187001698 putative substrate binding site [chemical binding]; other site 1199187001699 ATP binding site [chemical binding]; other site 1199187001700 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187001701 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187001702 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1199187001703 active site 1199187001704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001706 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1199187001707 active site 1199187001708 catalytic residues [active] 1199187001709 metal binding site [ion binding]; metal-binding site 1199187001710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187001711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187001712 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1199187001713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187001714 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1199187001715 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187001716 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1199187001717 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1199187001718 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1199187001719 NAD(P) binding site [chemical binding]; other site 1199187001720 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187001721 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187001722 active site 1199187001723 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187001724 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187001725 active site 1199187001726 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1199187001727 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1199187001728 active site 1199187001729 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187001730 PPE family; Region: PPE; pfam00823 1199187001731 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187001732 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187001733 PPE family; Region: PPE; pfam00823 1199187001734 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187001735 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1199187001736 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1199187001737 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1199187001738 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1199187001739 Ligand Binding Site [chemical binding]; other site 1199187001740 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1199187001741 heme-binding site [chemical binding]; other site 1199187001742 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1199187001743 ferredoxin-NADP+ reductase; Region: PLN02852 1199187001744 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1199187001745 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1199187001746 RF-1 domain; Region: RF-1; pfam00472 1199187001747 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1199187001748 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1199187001749 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1199187001750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187001751 Walker A/P-loop; other site 1199187001752 ATP binding site [chemical binding]; other site 1199187001753 Q-loop/lid; other site 1199187001754 ABC transporter signature motif; other site 1199187001755 Walker B; other site 1199187001756 D-loop; other site 1199187001757 H-loop/switch region; other site 1199187001758 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1199187001759 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1199187001760 FtsX-like permease family; Region: FtsX; pfam02687 1199187001761 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1199187001762 SmpB-tmRNA interface; other site 1199187001763 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1199187001764 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1199187001765 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1199187001766 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1199187001767 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1199187001768 homodimer interface [polypeptide binding]; other site 1199187001769 active site 1199187001770 TDP-binding site; other site 1199187001771 acceptor substrate-binding pocket; other site 1199187001772 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1199187001773 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1199187001774 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1199187001775 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1199187001776 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1199187001777 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1199187001778 putative active site [active] 1199187001779 catalytic site [active] 1199187001780 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1199187001781 putative active site [active] 1199187001782 catalytic site [active] 1199187001783 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187001784 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1199187001785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001786 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1199187001787 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1199187001788 hypothetical protein; Validated; Region: PRK00029 1199187001789 Hemerythrin-like domain; Region: Hr-like; cd12108 1199187001790 Fe binding site [ion binding]; other site 1199187001791 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1199187001792 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187001793 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187001794 active site 1199187001795 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1199187001796 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1199187001797 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1199187001798 camphor resistance protein CrcB; Provisional; Region: PRK14228 1199187001799 camphor resistance protein CrcB; Provisional; Region: PRK14216 1199187001800 phosphoglucomutase; Validated; Region: PRK07564 1199187001801 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1199187001802 active site 1199187001803 substrate binding site [chemical binding]; other site 1199187001804 metal binding site [ion binding]; metal-binding site 1199187001805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187001806 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1199187001807 putative substrate translocation pore; other site 1199187001808 Fic/DOC family; Region: Fic; cl00960 1199187001809 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187001810 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187001811 [2Fe-2S] cluster binding site [ion binding]; other site 1199187001812 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1199187001813 alpha subunit interface [polypeptide binding]; other site 1199187001814 active site 1199187001815 substrate binding site [chemical binding]; other site 1199187001816 Fe binding site [ion binding]; other site 1199187001817 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187001818 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1199187001819 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1199187001820 active site 1199187001821 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1199187001822 MarR family; Region: MarR_2; pfam12802 1199187001823 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1199187001824 phosphate binding motif [ion binding]; other site 1199187001825 beta-alpha-beta structure motif; other site 1199187001826 NAD binding pocket [chemical binding]; other site 1199187001827 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1199187001828 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187001829 catalytic loop [active] 1199187001830 iron binding site [ion binding]; other site 1199187001831 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187001832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187001833 NAD(P) binding site [chemical binding]; other site 1199187001834 active site 1199187001835 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187001836 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187001837 [2Fe-2S] cluster binding site [ion binding]; other site 1199187001838 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1199187001839 alpha subunit interface [polypeptide binding]; other site 1199187001840 active site 1199187001841 substrate binding site [chemical binding]; other site 1199187001842 Fe binding site [ion binding]; other site 1199187001843 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1199187001844 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1199187001845 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1199187001846 substrate binding pocket [chemical binding]; other site 1199187001847 active site 1199187001848 iron coordination sites [ion binding]; other site 1199187001849 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187001850 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187001851 Enolase [Carbohydrate transport and metabolism]; Region: Eno; COG0148 1199187001852 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1199187001853 dimer interface [polypeptide binding]; other site 1199187001854 metal binding site [ion binding]; metal-binding site 1199187001855 substrate binding pocket [chemical binding]; other site 1199187001856 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1199187001857 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1199187001858 Walker A/P-loop; other site 1199187001859 ATP binding site [chemical binding]; other site 1199187001860 Q-loop/lid; other site 1199187001861 ABC transporter signature motif; other site 1199187001862 Walker B; other site 1199187001863 D-loop; other site 1199187001864 H-loop/switch region; other site 1199187001865 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1199187001866 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1199187001867 Walker A/P-loop; other site 1199187001868 ATP binding site [chemical binding]; other site 1199187001869 Q-loop/lid; other site 1199187001870 ABC transporter signature motif; other site 1199187001871 Walker B; other site 1199187001872 D-loop; other site 1199187001873 H-loop/switch region; other site 1199187001874 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1199187001875 Transport protein; Region: actII; TIGR00833 1199187001876 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187001877 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1199187001878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187001879 short chain dehydrogenase; Provisional; Region: PRK07326 1199187001880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187001881 NAD(P) binding site [chemical binding]; other site 1199187001882 active site 1199187001883 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1199187001884 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187001885 putative active site [active] 1199187001886 putative substrate binding site [chemical binding]; other site 1199187001887 ATP binding site [chemical binding]; other site 1199187001888 MspA; Region: MspA; pfam09203 1199187001889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187001890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187001891 active site 1199187001892 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187001893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187001894 substrate binding site [chemical binding]; other site 1199187001895 oxyanion hole (OAH) forming residues; other site 1199187001896 trimer interface [polypeptide binding]; other site 1199187001897 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187001898 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1199187001899 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1199187001900 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1199187001901 nucleotide binding site [chemical binding]; other site 1199187001902 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1199187001903 SBD interface [polypeptide binding]; other site 1199187001904 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1199187001905 Carbon starvation protein CstA; Region: CstA; pfam02554 1199187001906 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1199187001907 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1199187001908 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1199187001909 active site 1199187001910 DNA binding site [nucleotide binding] 1199187001911 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1199187001912 DNA binding site [nucleotide binding] 1199187001913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187001914 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1199187001915 NAD(P) binding site [chemical binding]; other site 1199187001916 active site 1199187001917 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187001918 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187001919 active site 1199187001920 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1199187001921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187001922 DNA-binding site [nucleotide binding]; DNA binding site 1199187001923 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1199187001924 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1199187001925 FCD domain; Region: FCD; pfam07729 1199187001926 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1199187001927 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1199187001928 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1199187001929 2-isopropylmalate synthase; Validated; Region: PRK03739 1199187001930 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187001931 Cytochrome P450; Region: p450; cl12078 1199187001932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001934 short chain dehydrogenase; Provisional; Region: PRK07832 1199187001935 classical (c) SDRs; Region: SDR_c; cd05233 1199187001936 NAD(P) binding site [chemical binding]; other site 1199187001937 active site 1199187001938 DNA polymerase IV; Validated; Region: PRK03352 1199187001939 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1199187001940 active site 1199187001941 DNA binding site [nucleotide binding] 1199187001942 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1199187001943 Predicted flavoprotein [General function prediction only]; Region: COG0431 1199187001944 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1199187001945 catalytic residues [active] 1199187001946 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1199187001947 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1199187001948 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1199187001949 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1199187001950 active site 1199187001951 dimer interface [polypeptide binding]; other site 1199187001952 catalytic residues [active] 1199187001953 effector binding site; other site 1199187001954 R2 peptide binding site; other site 1199187001955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001957 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187001958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187001959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187001960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187001961 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1199187001962 putative hydrophobic ligand binding site [chemical binding]; other site 1199187001963 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1199187001964 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1199187001965 dimer interface [polypeptide binding]; other site 1199187001966 putative radical transfer pathway; other site 1199187001967 diiron center [ion binding]; other site 1199187001968 tyrosyl radical; other site 1199187001969 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1199187001970 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1199187001971 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1199187001972 putative NAD(P) binding site [chemical binding]; other site 1199187001973 putative substrate binding site [chemical binding]; other site 1199187001974 catalytic Zn binding site [ion binding]; other site 1199187001975 structural Zn binding site [ion binding]; other site 1199187001976 dimer interface [polypeptide binding]; other site 1199187001977 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1199187001978 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1199187001979 siderophore binding site; other site 1199187001980 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1199187001981 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1199187001982 D-pathway; other site 1199187001983 Putative ubiquinol binding site [chemical binding]; other site 1199187001984 Low-spin heme (heme b) binding site [chemical binding]; other site 1199187001985 Putative water exit pathway; other site 1199187001986 Binuclear center (heme o3/CuB) [ion binding]; other site 1199187001987 K-pathway; other site 1199187001988 Putative proton exit pathway; other site 1199187001989 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1199187001990 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1199187001991 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1199187001992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187001993 motif II; other site 1199187001994 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1199187001995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187001996 Walker A/P-loop; other site 1199187001997 ATP binding site [chemical binding]; other site 1199187001998 ABC transporter signature motif; other site 1199187001999 Walker B; other site 1199187002000 D-loop; other site 1199187002001 H-loop/switch region; other site 1199187002002 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1199187002003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187002004 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1199187002005 substrate binding site [chemical binding]; other site 1199187002006 oxyanion hole (OAH) forming residues; other site 1199187002007 trimer interface [polypeptide binding]; other site 1199187002008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187002009 S-adenosylmethionine binding site [chemical binding]; other site 1199187002010 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1199187002011 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1199187002012 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1199187002013 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1199187002014 trimer interface [polypeptide binding]; other site 1199187002015 active site 1199187002016 substrate binding site [chemical binding]; other site 1199187002017 CoA binding site [chemical binding]; other site 1199187002018 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1199187002019 DNA photolyase; Region: DNA_photolyase; pfam00875 1199187002020 TspO/MBR family; Region: TspO_MBR; cl01379 1199187002021 TspO/MBR family; Region: TspO_MBR; cl01379 1199187002022 MMPL family; Region: MMPL; pfam03176 1199187002023 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1199187002024 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1199187002025 homotetramer interface [polypeptide binding]; other site 1199187002026 FMN binding site [chemical binding]; other site 1199187002027 homodimer contacts [polypeptide binding]; other site 1199187002028 putative active site [active] 1199187002029 putative substrate binding site [chemical binding]; other site 1199187002030 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1199187002031 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187002032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187002033 Integrase core domain; Region: rve; pfam00665 1199187002034 Integrase core domain; Region: rve_3; pfam13683 1199187002035 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1199187002036 MarR family; Region: MarR_2; pfam12802 1199187002037 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1199187002038 [2Fe-2S] cluster binding site [ion binding]; other site 1199187002039 iron-sulfur cluster [ion binding]; other site 1199187002040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187002041 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1199187002042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1199187002043 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1199187002044 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1199187002045 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1199187002046 active site lid residues [active] 1199187002047 substrate binding pocket [chemical binding]; other site 1199187002048 catalytic residues [active] 1199187002049 substrate-Mg2+ binding site; other site 1199187002050 aspartate-rich region 1; other site 1199187002051 aspartate-rich region 2; other site 1199187002052 phytoene desaturase; Region: crtI_fam; TIGR02734 1199187002053 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1199187002054 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1199187002055 substrate binding pocket [chemical binding]; other site 1199187002056 chain length determination region; other site 1199187002057 substrate-Mg2+ binding site; other site 1199187002058 catalytic residues [active] 1199187002059 aspartate-rich region 1; other site 1199187002060 active site lid residues [active] 1199187002061 aspartate-rich region 2; other site 1199187002062 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187002063 anti sigma factor interaction site; other site 1199187002064 regulatory phosphorylation site [posttranslational modification]; other site 1199187002065 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1199187002066 putative hydrophobic ligand binding site [chemical binding]; other site 1199187002067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187002068 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1199187002069 NAD(P) binding site [chemical binding]; other site 1199187002070 active site 1199187002071 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187002072 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1199187002073 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1199187002074 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1199187002075 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1199187002076 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1199187002077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187002078 S-adenosylmethionine binding site [chemical binding]; other site 1199187002079 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1199187002080 Ligand binding site [chemical binding]; other site 1199187002081 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1199187002082 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1199187002083 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1199187002084 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1199187002085 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1199187002086 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1199187002087 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1199187002088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187002089 catalytic residue [active] 1199187002090 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1199187002091 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1199187002092 Ligand Binding Site [chemical binding]; other site 1199187002093 PknH-like extracellular domain; Region: PknH_C; pfam14032 1199187002094 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1199187002095 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1199187002096 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1199187002097 nucleotide binding pocket [chemical binding]; other site 1199187002098 K-X-D-G motif; other site 1199187002099 catalytic site [active] 1199187002100 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1199187002101 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1199187002102 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1199187002103 Dimer interface [polypeptide binding]; other site 1199187002104 cystathionine gamma-lyase; Validated; Region: PRK07582 1199187002105 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187002106 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187002107 catalytic residue [active] 1199187002108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187002109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187002110 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1199187002111 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1199187002112 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1199187002113 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1199187002114 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1199187002115 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1199187002116 6-phosphofructokinase; Provisional; Region: PRK03202 1199187002117 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1199187002118 active site 1199187002119 ADP/pyrophosphate binding site [chemical binding]; other site 1199187002120 dimerization interface [polypeptide binding]; other site 1199187002121 allosteric effector site; other site 1199187002122 fructose-1,6-bisphosphate binding site; other site 1199187002123 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1199187002124 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1199187002125 P-loop; other site 1199187002126 Magnesium ion binding site [ion binding]; other site 1199187002127 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1199187002128 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1199187002129 GatB domain; Region: GatB_Yqey; smart00845 1199187002130 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1199187002131 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1199187002132 Predicted membrane protein [Function unknown]; Region: COG2259 1199187002133 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1199187002134 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1199187002135 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1199187002136 PYR/PP interface [polypeptide binding]; other site 1199187002137 dimer interface [polypeptide binding]; other site 1199187002138 TPP binding site [chemical binding]; other site 1199187002139 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1199187002140 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1199187002141 TPP-binding site [chemical binding]; other site 1199187002142 dimer interface [polypeptide binding]; other site 1199187002143 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1199187002144 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1199187002145 putative valine binding site [chemical binding]; other site 1199187002146 dimer interface [polypeptide binding]; other site 1199187002147 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1199187002148 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1199187002149 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1199187002150 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1199187002151 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1199187002152 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1199187002153 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1199187002154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187002155 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1199187002156 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1199187002157 ligand binding site [chemical binding]; other site 1199187002158 NAD binding site [chemical binding]; other site 1199187002159 dimerization interface [polypeptide binding]; other site 1199187002160 catalytic site [active] 1199187002161 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1199187002162 putative L-serine binding site [chemical binding]; other site 1199187002163 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1199187002164 tartrate dehydrogenase; Region: TTC; TIGR02089 1199187002165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187002166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1199187002167 putative substrate translocation pore; other site 1199187002168 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1199187002169 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1199187002170 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1199187002171 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1199187002172 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187002173 active site 1199187002174 HIGH motif; other site 1199187002175 nucleotide binding site [chemical binding]; other site 1199187002176 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1199187002177 active site 1199187002178 KMSKS motif; other site 1199187002179 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1199187002180 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1199187002181 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1199187002182 Bacterial transcriptional regulator; Region: IclR; pfam01614 1199187002183 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1199187002184 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1199187002185 substrate binding site [chemical binding]; other site 1199187002186 ligand binding site [chemical binding]; other site 1199187002187 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1199187002188 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1199187002189 substrate binding site [chemical binding]; other site 1199187002190 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1199187002191 IHF - DNA interface [nucleotide binding]; other site 1199187002192 IHF dimer interface [polypeptide binding]; other site 1199187002193 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1199187002194 active site 1199187002195 Ap6A binding site [chemical binding]; other site 1199187002196 nudix motif; other site 1199187002197 metal binding site [ion binding]; metal-binding site 1199187002198 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187002199 catalytic core [active] 1199187002200 polyphosphate kinase; Provisional; Region: PRK05443 1199187002201 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1199187002202 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1199187002203 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1199187002204 putative domain interface [polypeptide binding]; other site 1199187002205 putative active site [active] 1199187002206 catalytic site [active] 1199187002207 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1199187002208 putative domain interface [polypeptide binding]; other site 1199187002209 putative active site [active] 1199187002210 catalytic site [active] 1199187002211 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1199187002212 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1199187002213 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1199187002214 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1199187002215 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1199187002216 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1199187002217 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1199187002218 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1199187002219 thiamine monophosphate kinase; Provisional; Region: PRK05731 1199187002220 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1199187002221 ATP binding site [chemical binding]; other site 1199187002222 dimerization interface [polypeptide binding]; other site 1199187002223 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1199187002224 ligand binding site [chemical binding]; other site 1199187002225 active site 1199187002226 UGI interface [polypeptide binding]; other site 1199187002227 catalytic site [active] 1199187002228 short chain dehydrogenase; Provisional; Region: PRK06180 1199187002229 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1199187002230 NADP binding site [chemical binding]; other site 1199187002231 active site 1199187002232 steroid binding site; other site 1199187002233 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1199187002234 short chain dehydrogenase; Provisional; Region: PRK06197 1199187002235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187002236 NAD(P) binding site [chemical binding]; other site 1199187002237 active site 1199187002238 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187002239 classical (c) SDRs; Region: SDR_c; cd05233 1199187002240 NAD(P) binding site [chemical binding]; other site 1199187002241 active site 1199187002242 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1199187002243 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1199187002244 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1199187002245 DAK2 domain; Region: Dak2; pfam02734 1199187002246 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1199187002247 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1199187002248 ssDNA binding site; other site 1199187002249 generic binding surface II; other site 1199187002250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187002251 ATP binding site [chemical binding]; other site 1199187002252 putative Mg++ binding site [ion binding]; other site 1199187002253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187002254 nucleotide binding region [chemical binding]; other site 1199187002255 ATP-binding site [chemical binding]; other site 1199187002256 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1199187002257 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187002258 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187002259 active site 1199187002260 catalytic tetrad [active] 1199187002261 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187002262 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187002263 substrate binding pocket [chemical binding]; other site 1199187002264 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1199187002265 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1199187002266 catalytic residues [active] 1199187002267 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1199187002268 putative active site [active] 1199187002269 redox center [active] 1199187002270 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1199187002271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1199187002272 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1199187002273 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1199187002274 active site 1199187002275 (T/H)XGH motif; other site 1199187002276 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187002277 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187002278 active site 1199187002279 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1199187002280 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1199187002281 PYR/PP interface [polypeptide binding]; other site 1199187002282 dimer interface [polypeptide binding]; other site 1199187002283 TPP binding site [chemical binding]; other site 1199187002284 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1199187002285 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1199187002286 TPP-binding site [chemical binding]; other site 1199187002287 dimer interface [polypeptide binding]; other site 1199187002288 Predicted permease; Region: DUF318; cl17795 1199187002289 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1199187002290 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1199187002291 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1199187002292 ribonuclease III; Reviewed; Region: rnc; PRK00102 1199187002293 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1199187002294 dimerization interface [polypeptide binding]; other site 1199187002295 active site 1199187002296 metal binding site [ion binding]; metal-binding site 1199187002297 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1199187002298 dsRNA binding site [nucleotide binding]; other site 1199187002299 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1199187002300 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1199187002301 DNA binding site [nucleotide binding] 1199187002302 catalytic residue [active] 1199187002303 H2TH interface [polypeptide binding]; other site 1199187002304 putative catalytic residues [active] 1199187002305 turnover-facilitating residue; other site 1199187002306 intercalation triad [nucleotide binding]; other site 1199187002307 8OG recognition residue [nucleotide binding]; other site 1199187002308 putative reading head residues; other site 1199187002309 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1199187002310 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1199187002311 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1199187002312 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1199187002313 acylphosphatase; Provisional; Region: PRK14422 1199187002314 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1199187002315 AAA domain; Region: AAA_23; pfam13476 1199187002316 Walker A/P-loop; other site 1199187002317 ATP binding site [chemical binding]; other site 1199187002318 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1199187002319 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1199187002320 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1199187002321 ABC transporter signature motif; other site 1199187002322 Walker B; other site 1199187002323 D-loop; other site 1199187002324 H-loop/switch region; other site 1199187002325 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1199187002326 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1199187002327 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1199187002328 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1199187002329 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1199187002330 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1199187002331 PII uridylyl-transferase; Provisional; Region: PRK03381 1199187002332 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1199187002333 metal binding triad; other site 1199187002334 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1199187002335 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1199187002336 Zn2+ binding site [ion binding]; other site 1199187002337 Mg2+ binding site [ion binding]; other site 1199187002338 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1199187002339 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1199187002340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187002341 ATP binding site [chemical binding]; other site 1199187002342 putative Mg++ binding site [ion binding]; other site 1199187002343 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187002344 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1199187002345 signal recognition particle protein; Provisional; Region: PRK10867 1199187002346 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1199187002347 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1199187002348 P loop; other site 1199187002349 GTP binding site [chemical binding]; other site 1199187002350 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1199187002351 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1199187002352 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187002353 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187002354 active site 1199187002355 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1199187002356 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187002357 active site 1199187002358 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187002359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187002360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187002361 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1199187002362 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1199187002363 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1199187002364 SnoaL-like domain; Region: SnoaL_3; pfam13474 1199187002365 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1199187002366 hypothetical protein; Provisional; Region: PRK02821 1199187002367 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1199187002368 G-X-X-G motif; other site 1199187002369 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1199187002370 RimM N-terminal domain; Region: RimM; pfam01782 1199187002371 PRC-barrel domain; Region: PRC; pfam05239 1199187002372 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1199187002373 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1199187002374 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1199187002375 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1199187002376 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1199187002377 Catalytic site [active] 1199187002378 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1199187002379 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1199187002380 RNA/DNA hybrid binding site [nucleotide binding]; other site 1199187002381 active site 1199187002382 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1199187002383 ANTAR domain; Region: ANTAR; pfam03861 1199187002384 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1199187002385 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1199187002386 putative NAD(P) binding site [chemical binding]; other site 1199187002387 active site 1199187002388 putative substrate binding site [chemical binding]; other site 1199187002389 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1199187002390 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1199187002391 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1199187002392 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187002393 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1199187002394 active site 1199187002395 DNA binding site [nucleotide binding] 1199187002396 Int/Topo IB signature motif; other site 1199187002397 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1199187002398 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1199187002399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187002400 Walker A motif; other site 1199187002401 ATP binding site [chemical binding]; other site 1199187002402 Walker B motif; other site 1199187002403 arginine finger; other site 1199187002404 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1199187002405 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1199187002406 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1199187002407 DNA protecting protein DprA; Region: dprA; TIGR00732 1199187002408 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1199187002409 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1199187002410 FAD binding pocket [chemical binding]; other site 1199187002411 FAD binding motif [chemical binding]; other site 1199187002412 phosphate binding motif [ion binding]; other site 1199187002413 NAD binding pocket [chemical binding]; other site 1199187002414 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1199187002415 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1199187002416 putative active site [active] 1199187002417 putative substrate binding site [chemical binding]; other site 1199187002418 putative FMN binding site [chemical binding]; other site 1199187002419 putative catalytic residues [active] 1199187002420 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1199187002421 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187002422 active site 1199187002423 DNA binding site [nucleotide binding] 1199187002424 Int/Topo IB signature motif; other site 1199187002425 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1199187002426 Peptidase family M23; Region: Peptidase_M23; pfam01551 1199187002427 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1199187002428 rRNA interaction site [nucleotide binding]; other site 1199187002429 S8 interaction site; other site 1199187002430 putative laminin-1 binding site; other site 1199187002431 elongation factor Ts; Provisional; Region: tsf; PRK09377 1199187002432 UBA/TS-N domain; Region: UBA; pfam00627 1199187002433 Elongation factor TS; Region: EF_TS; pfam00889 1199187002434 Elongation factor TS; Region: EF_TS; pfam00889 1199187002435 amidase; Provisional; Region: PRK07869 1199187002436 Amidase; Region: Amidase; pfam01425 1199187002437 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1199187002438 MarR family; Region: MarR; pfam01047 1199187002439 ChaB; Region: ChaB; pfam06150 1199187002440 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1199187002441 short chain dehydrogenase; Provisional; Region: PRK06701 1199187002442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187002443 NAD(P) binding site [chemical binding]; other site 1199187002444 active site 1199187002445 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1199187002446 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187002447 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1199187002448 putative acyl-acceptor binding pocket; other site 1199187002449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187002450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187002451 DNA binding site [nucleotide binding] 1199187002452 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1199187002453 putative nucleotide binding site [chemical binding]; other site 1199187002454 uridine monophosphate binding site [chemical binding]; other site 1199187002455 homohexameric interface [polypeptide binding]; other site 1199187002456 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1199187002457 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1199187002458 hinge region; other site 1199187002459 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1199187002460 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1199187002461 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1199187002462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1199187002463 FeS/SAM binding site; other site 1199187002464 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1199187002465 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1199187002466 catalytic residues [active] 1199187002467 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1199187002468 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1199187002469 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1199187002470 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1199187002471 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1199187002472 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1199187002473 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1199187002474 active site 1199187002475 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1199187002476 protein binding site [polypeptide binding]; other site 1199187002477 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1199187002478 putative substrate binding region [chemical binding]; other site 1199187002479 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1199187002480 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1199187002481 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1199187002482 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1199187002483 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1199187002484 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1199187002485 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1199187002486 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1199187002487 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1199187002488 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1199187002489 active site 1199187002490 cobyric acid synthase; Provisional; Region: PRK00784 1199187002491 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1199187002492 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1199187002493 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1199187002494 catalytic triad [active] 1199187002495 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187002496 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1199187002497 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1199187002498 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1199187002499 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1199187002500 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1199187002501 catalytic triad [active] 1199187002502 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1199187002503 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1199187002504 NAD(P) binding site [chemical binding]; other site 1199187002505 catalytic residues [active] 1199187002506 short chain dehydrogenase; Provisional; Region: PRK06057 1199187002507 classical (c) SDRs; Region: SDR_c; cd05233 1199187002508 NAD(P) binding site [chemical binding]; other site 1199187002509 active site 1199187002510 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187002511 PPE family; Region: PPE; pfam00823 1199187002512 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1199187002513 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1199187002514 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1199187002515 mycothione reductase; Reviewed; Region: PRK07846 1199187002516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187002517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187002518 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1199187002519 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1199187002520 malate:quinone oxidoreductase; Validated; Region: PRK05257 1199187002521 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1199187002522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1199187002523 Coenzyme A binding pocket [chemical binding]; other site 1199187002524 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1199187002525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1199187002526 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1199187002527 metal ion-dependent adhesion site (MIDAS); other site 1199187002528 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1199187002529 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1199187002530 Walker A motif; other site 1199187002531 homodimer interface [polypeptide binding]; other site 1199187002532 ATP binding site [chemical binding]; other site 1199187002533 hydroxycobalamin binding site [chemical binding]; other site 1199187002534 Walker B motif; other site 1199187002535 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1199187002536 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1199187002537 catalytic triad [active] 1199187002538 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1199187002539 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1199187002540 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1199187002541 active site 1199187002542 SAM binding site [chemical binding]; other site 1199187002543 homodimer interface [polypeptide binding]; other site 1199187002544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187002545 putative substrate translocation pore; other site 1199187002546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187002547 hypothetical protein; Provisional; Region: PRK01346 1199187002548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1199187002549 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1199187002550 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1199187002551 dimer interface [polypeptide binding]; other site 1199187002552 motif 1; other site 1199187002553 active site 1199187002554 motif 2; other site 1199187002555 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1199187002556 putative deacylase active site [active] 1199187002557 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1199187002558 active site 1199187002559 motif 3; other site 1199187002560 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1199187002561 anticodon binding site; other site 1199187002562 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1199187002563 dinuclear metal binding motif [ion binding]; other site 1199187002564 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1199187002565 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1199187002566 putative oligomer interface [polypeptide binding]; other site 1199187002567 putative RNA binding site [nucleotide binding]; other site 1199187002568 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1199187002569 NusA N-terminal domain; Region: NusA_N; pfam08529 1199187002570 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1199187002571 RNA binding site [nucleotide binding]; other site 1199187002572 homodimer interface [polypeptide binding]; other site 1199187002573 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1199187002574 G-X-X-G motif; other site 1199187002575 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1199187002576 G-X-X-G motif; other site 1199187002577 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1199187002578 putative RNA binding cleft [nucleotide binding]; other site 1199187002579 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1199187002580 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1199187002581 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1199187002582 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1199187002583 G1 box; other site 1199187002584 putative GEF interaction site [polypeptide binding]; other site 1199187002585 GTP/Mg2+ binding site [chemical binding]; other site 1199187002586 Switch I region; other site 1199187002587 G2 box; other site 1199187002588 G3 box; other site 1199187002589 Switch II region; other site 1199187002590 G4 box; other site 1199187002591 G5 box; other site 1199187002592 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1199187002593 Translation-initiation factor 2; Region: IF-2; pfam11987 1199187002594 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1199187002595 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1199187002596 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1199187002597 DHH family; Region: DHH; pfam01368 1199187002598 enoyl-CoA hydratase; Provisional; Region: PRK06190 1199187002599 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187002600 substrate binding site [chemical binding]; other site 1199187002601 oxyanion hole (OAH) forming residues; other site 1199187002602 trimer interface [polypeptide binding]; other site 1199187002603 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1199187002604 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1199187002605 Predicted acyl esterases [General function prediction only]; Region: COG2936 1199187002606 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1199187002607 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1199187002608 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1199187002609 active site 1199187002610 metal binding site [ion binding]; metal-binding site 1199187002611 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1199187002612 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1199187002613 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1199187002614 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1199187002615 RNA binding site [nucleotide binding]; other site 1199187002616 active site 1199187002617 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1199187002618 lipid-transfer protein; Provisional; Region: PRK08256 1199187002619 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187002620 active site 1199187002621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187002622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187002623 active site 1199187002624 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1199187002625 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1199187002626 active site 1199187002627 Riboflavin kinase; Region: Flavokinase; smart00904 1199187002628 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1199187002629 16S/18S rRNA binding site [nucleotide binding]; other site 1199187002630 S13e-L30e interaction site [polypeptide binding]; other site 1199187002631 25S rRNA binding site [nucleotide binding]; other site 1199187002632 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1199187002633 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1199187002634 oligomer interface [polypeptide binding]; other site 1199187002635 RNA binding site [nucleotide binding]; other site 1199187002636 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1199187002637 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1199187002638 RNase E interface [polypeptide binding]; other site 1199187002639 trimer interface [polypeptide binding]; other site 1199187002640 active site 1199187002641 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1199187002642 putative nucleic acid binding region [nucleotide binding]; other site 1199187002643 G-X-X-G motif; other site 1199187002644 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1199187002645 RNA binding site [nucleotide binding]; other site 1199187002646 domain interface; other site 1199187002647 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1199187002648 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1199187002649 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1199187002650 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1199187002651 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1199187002652 FMN binding site [chemical binding]; other site 1199187002653 substrate binding site [chemical binding]; other site 1199187002654 putative catalytic residue [active] 1199187002655 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1199187002656 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1199187002657 hexamer interface [polypeptide binding]; other site 1199187002658 ligand binding site [chemical binding]; other site 1199187002659 putative active site [active] 1199187002660 NAD(P) binding site [chemical binding]; other site 1199187002661 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1199187002662 hydrophobic ligand binding site; other site 1199187002663 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1199187002664 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1199187002665 short chain dehydrogenase; Validated; Region: PRK05855 1199187002666 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187002667 classical (c) SDRs; Region: SDR_c; cd05233 1199187002668 NAD(P) binding site [chemical binding]; other site 1199187002669 active site 1199187002670 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1199187002671 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1199187002672 FMN-binding pocket [chemical binding]; other site 1199187002673 flavin binding motif; other site 1199187002674 phosphate binding motif [ion binding]; other site 1199187002675 beta-alpha-beta structure motif; other site 1199187002676 NAD binding pocket [chemical binding]; other site 1199187002677 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187002678 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1199187002679 catalytic loop [active] 1199187002680 iron binding site [ion binding]; other site 1199187002681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187002682 Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...; Region: Bcl-2_like; cl02575 1199187002683 BH3; other site 1199187002684 BH3-homology region binding site; other site 1199187002685 BH1; other site 1199187002686 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187002687 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187002688 [2Fe-2S] cluster binding site [ion binding]; other site 1199187002689 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187002690 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1199187002691 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187002692 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187002693 active site 1199187002694 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1199187002695 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1199187002696 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1199187002697 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1199187002698 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1199187002699 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1199187002700 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1199187002701 active site 2 [active] 1199187002702 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1199187002703 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187002704 acyl-activating enzyme (AAE) consensus motif; other site 1199187002705 AMP binding site [chemical binding]; other site 1199187002706 active site 1199187002707 CoA binding site [chemical binding]; other site 1199187002708 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1199187002709 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1199187002710 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1199187002711 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1199187002712 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1199187002713 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1199187002714 carboxyltransferase (CT) interaction site; other site 1199187002715 biotinylation site [posttranslational modification]; other site 1199187002716 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1199187002717 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1199187002718 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1199187002719 classical (c) SDRs; Region: SDR_c; cd05233 1199187002720 NAD(P) binding site [chemical binding]; other site 1199187002721 active site 1199187002722 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1199187002723 homodimer interface [polypeptide binding]; other site 1199187002724 active site 1199187002725 TDP-binding site; other site 1199187002726 acceptor substrate-binding pocket; other site 1199187002727 Dienelactone hydrolase family; Region: DLH; pfam01738 1199187002728 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1199187002729 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1199187002730 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1199187002731 dimerization interface [polypeptide binding]; other site 1199187002732 active site 1199187002733 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1199187002734 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1199187002735 folate binding site [chemical binding]; other site 1199187002736 NADP+ binding site [chemical binding]; other site 1199187002737 DivIVA protein; Region: DivIVA; pfam05103 1199187002738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1199187002739 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1199187002740 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1199187002741 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1199187002742 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1199187002743 dimer interface [polypeptide binding]; other site 1199187002744 active site 1199187002745 catalytic residue [active] 1199187002746 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1199187002747 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187002748 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1199187002749 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187002750 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187002751 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1199187002752 classical (c) SDRs; Region: SDR_c; cd05233 1199187002753 NAD(P) binding site [chemical binding]; other site 1199187002754 active site 1199187002755 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1199187002756 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1199187002757 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187002758 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1199187002759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1199187002760 Coenzyme A binding pocket [chemical binding]; other site 1199187002761 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1199187002762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187002763 non-specific DNA binding site [nucleotide binding]; other site 1199187002764 salt bridge; other site 1199187002765 sequence-specific DNA binding site [nucleotide binding]; other site 1199187002766 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1199187002767 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 1199187002768 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1199187002769 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1199187002770 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1199187002771 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1199187002772 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1199187002773 recombinase A; Provisional; Region: recA; PRK09354 1199187002774 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1199187002775 hexamer interface [polypeptide binding]; other site 1199187002776 Walker A motif; other site 1199187002777 ATP binding site [chemical binding]; other site 1199187002778 Walker B motif; other site 1199187002779 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1199187002780 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1199187002781 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1199187002782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1199187002783 FeS/SAM binding site; other site 1199187002784 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1199187002785 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1199187002786 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1199187002787 active site 1199187002788 metal binding site [ion binding]; metal-binding site 1199187002789 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1199187002790 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1199187002791 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1199187002792 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1199187002793 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1199187002794 GTPases [General function prediction only]; Region: HflX; COG2262 1199187002795 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1199187002796 HflX GTPase family; Region: HflX; cd01878 1199187002797 G1 box; other site 1199187002798 GTP/Mg2+ binding site [chemical binding]; other site 1199187002799 Switch I region; other site 1199187002800 G2 box; other site 1199187002801 G3 box; other site 1199187002802 Switch II region; other site 1199187002803 G4 box; other site 1199187002804 G5 box; other site 1199187002805 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1199187002806 LGFP repeat; Region: LGFP; pfam08310 1199187002807 LGFP repeat; Region: LGFP; pfam08310 1199187002808 LGFP repeat; Region: LGFP; pfam08310 1199187002809 LGFP repeat; Region: LGFP; pfam08310 1199187002810 LGFP repeat; Region: LGFP; pfam08310 1199187002811 LGFP repeat; Region: LGFP; pfam08310 1199187002812 LexA repressor; Validated; Region: PRK00215 1199187002813 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1199187002814 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1199187002815 Catalytic site [active] 1199187002816 LysM domain; Region: LysM; pfam01476 1199187002817 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1199187002818 ATP cone domain; Region: ATP-cone; pfam03477 1199187002819 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1199187002820 heme-binding site [chemical binding]; other site 1199187002821 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1199187002822 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187002823 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1199187002824 PAC2 family; Region: PAC2; pfam09754 1199187002825 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1199187002826 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1199187002827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187002828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187002829 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1199187002830 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1199187002831 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1199187002832 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1199187002833 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1199187002834 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1199187002835 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1199187002836 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1199187002837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187002838 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1199187002839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187002840 DNA binding residues [nucleotide binding] 1199187002841 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1199187002842 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1199187002843 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1199187002844 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1199187002845 homotrimer interaction site [polypeptide binding]; other site 1199187002846 putative active site [active] 1199187002847 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1199187002848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187002849 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1199187002850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187002851 DNA binding residues [nucleotide binding] 1199187002852 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1199187002853 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1199187002854 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1199187002855 active site 1199187002856 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1199187002857 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1199187002858 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1199187002859 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1199187002860 trimer interface [polypeptide binding]; other site 1199187002861 active site 1199187002862 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1199187002863 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1199187002864 generic binding surface II; other site 1199187002865 ssDNA binding site; other site 1199187002866 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1199187002867 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1199187002868 TrkA-N domain; Region: TrkA_N; pfam02254 1199187002869 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1199187002870 TrkA-N domain; Region: TrkA_N; pfam02254 1199187002871 TrkA-C domain; Region: TrkA_C; pfam02080 1199187002872 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1199187002873 TRAM domain; Region: TRAM; pfam01938 1199187002874 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1199187002875 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1199187002876 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1199187002877 transmembrane helices; other site 1199187002878 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1199187002879 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1199187002880 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1199187002881 TPP-binding site; other site 1199187002882 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1199187002883 PYR/PP interface [polypeptide binding]; other site 1199187002884 dimer interface [polypeptide binding]; other site 1199187002885 TPP binding site [chemical binding]; other site 1199187002886 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1199187002887 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1199187002888 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1199187002889 catalytic site [active] 1199187002890 putative active site [active] 1199187002891 putative substrate binding site [chemical binding]; other site 1199187002892 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1199187002893 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1199187002894 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187002895 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187002896 substrate binding site [chemical binding]; other site 1199187002897 oxyanion hole (OAH) forming residues; other site 1199187002898 trimer interface [polypeptide binding]; other site 1199187002899 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1199187002900 substrate binding site [chemical binding]; other site 1199187002901 active site 1199187002902 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1199187002903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187002904 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1199187002905 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1199187002906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187002907 S-adenosylmethionine binding site [chemical binding]; other site 1199187002908 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1199187002909 SelR domain; Region: SelR; pfam01641 1199187002910 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1199187002911 TAP-like protein; Region: Abhydrolase_4; pfam08386 1199187002912 hypothetical protein; Provisional; Region: PRK14059 1199187002913 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1199187002914 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1199187002915 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1199187002916 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1199187002917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1199187002918 Coenzyme A binding pocket [chemical binding]; other site 1199187002919 Clp protease ATP binding subunit; Region: clpC; CHL00095 1199187002920 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187002921 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187002922 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1199187002923 Cation efflux family; Region: Cation_efflux; cl00316 1199187002924 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1199187002925 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1199187002926 NAD(P) binding site [chemical binding]; other site 1199187002927 catalytic residues [active] 1199187002928 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1199187002929 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1199187002930 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187002931 classical (c) SDRs; Region: SDR_c; cd05233 1199187002932 NAD(P) binding site [chemical binding]; other site 1199187002933 active site 1199187002934 short chain dehydrogenase; Provisional; Region: PRK12827 1199187002935 classical (c) SDRs; Region: SDR_c; cd05233 1199187002936 NAD(P) binding site [chemical binding]; other site 1199187002937 active site 1199187002938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187002939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187002940 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187002941 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1199187002942 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1199187002943 hypothetical protein; Provisional; Region: PRK06194 1199187002944 classical (c) SDRs; Region: SDR_c; cd05233 1199187002945 NAD(P) binding site [chemical binding]; other site 1199187002946 active site 1199187002947 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1199187002948 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187002949 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187002950 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1199187002951 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187002952 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 1199187002953 AAA domain; Region: AAA_25; pfam13481 1199187002954 Helix-turn-helix domain; Region: HTH_17; pfam12728 1199187002955 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1199187002956 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1199187002957 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1199187002958 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1199187002959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187002960 active site 1199187002961 DNA binding site [nucleotide binding] 1199187002962 Int/Topo IB signature motif; other site 1199187002963 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1199187002964 hydrophobic ligand binding site; other site 1199187002965 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187002966 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187002967 substrate binding site [chemical binding]; other site 1199187002968 oxyanion hole (OAH) forming residues; other site 1199187002969 trimer interface [polypeptide binding]; other site 1199187002970 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1199187002971 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187002972 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1199187002973 acyl-activating enzyme (AAE) consensus motif; other site 1199187002974 acyl-activating enzyme (AAE) consensus motif; other site 1199187002975 putative AMP binding site [chemical binding]; other site 1199187002976 putative active site [active] 1199187002977 putative CoA binding site [chemical binding]; other site 1199187002978 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187002979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187002980 NAD(P) binding site [chemical binding]; other site 1199187002981 active site 1199187002982 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1199187002983 putative heme binding pocket [chemical binding]; other site 1199187002984 Predicted permeases [General function prediction only]; Region: COG0730 1199187002985 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187002986 anti sigma factor interaction site; other site 1199187002987 regulatory phosphorylation site [posttranslational modification]; other site 1199187002988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187002989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187002990 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1199187002991 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1199187002992 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1199187002993 active site 1199187002994 catalytic triad [active] 1199187002995 oxyanion hole [active] 1199187002996 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1199187002997 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1199187002998 Bacterial transcriptional regulator; Region: IclR; pfam01614 1199187002999 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1199187003000 intersubunit interface [polypeptide binding]; other site 1199187003001 active site 1199187003002 Zn2+ binding site [ion binding]; other site 1199187003003 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1199187003004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187003005 NAD(P) binding site [chemical binding]; other site 1199187003006 active site 1199187003007 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1199187003008 inter-subunit interface; other site 1199187003009 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 1199187003010 alpha subunit interaction site [polypeptide binding]; other site 1199187003011 beta subunit interaction site [polypeptide binding]; other site 1199187003012 iron-sulfur cluster [ion binding]; other site 1199187003013 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1199187003014 beta subunit interface [polypeptide binding]; other site 1199187003015 alpha subunit interface [polypeptide binding]; other site 1199187003016 active site 1199187003017 substrate binding site [chemical binding]; other site 1199187003018 Fe binding site [ion binding]; other site 1199187003019 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1199187003020 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1199187003021 iron-sulfur cluster [ion binding]; other site 1199187003022 [2Fe-2S] cluster binding site [ion binding]; other site 1199187003023 Hemerythrin-like domain; Region: Hr-like; cd12108 1199187003024 Fe binding site [ion binding]; other site 1199187003025 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1199187003026 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1199187003027 active site 1199187003028 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1199187003029 heterodimer interface [polypeptide binding]; other site 1199187003030 active site 1199187003031 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1199187003032 tetramer interface [polypeptide binding]; other site 1199187003033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1199187003034 Ferredoxin [Energy production and conversion]; Region: COG1146 1199187003035 4Fe-4S binding domain; Region: Fer4; pfam00037 1199187003036 Helix-turn-helix domain; Region: HTH_20; pfam12840 1199187003037 Predicted transcriptional regulator [Transcription]; Region: COG2345 1199187003038 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1199187003039 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1199187003040 FMN binding site [chemical binding]; other site 1199187003041 substrate binding site [chemical binding]; other site 1199187003042 putative catalytic residue [active] 1199187003043 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1199187003044 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187003045 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187003046 active site 1199187003047 catalytic tetrad [active] 1199187003048 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187003049 CoenzymeA binding site [chemical binding]; other site 1199187003050 subunit interaction site [polypeptide binding]; other site 1199187003051 PHB binding site; other site 1199187003052 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1199187003053 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1199187003054 metal binding site [ion binding]; metal-binding site 1199187003055 putative dimer interface [polypeptide binding]; other site 1199187003056 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1199187003057 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1199187003058 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1199187003059 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1199187003060 active site 1199187003061 dimer interface [polypeptide binding]; other site 1199187003062 motif 1; other site 1199187003063 motif 2; other site 1199187003064 motif 3; other site 1199187003065 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1199187003066 anticodon binding site; other site 1199187003067 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1199187003068 nucleotide binding site/active site [active] 1199187003069 HIT family signature motif; other site 1199187003070 catalytic residue [active] 1199187003071 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1199187003072 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1199187003073 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1199187003074 putative acyl-acceptor binding pocket; other site 1199187003075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187003076 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1199187003077 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1199187003078 nudix motif; other site 1199187003079 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1199187003080 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1199187003081 active site 1199187003082 multimer interface [polypeptide binding]; other site 1199187003083 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1199187003084 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1199187003085 active site 1199187003086 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1199187003087 catalytic triad [active] 1199187003088 dimer interface [polypeptide binding]; other site 1199187003089 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 1199187003090 conserved cys residue [active] 1199187003091 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1199187003092 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1199187003093 catalytic residues [active] 1199187003094 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1199187003095 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1199187003096 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1199187003097 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1199187003098 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1199187003099 catalytic residue [active] 1199187003100 putative FPP diphosphate binding site; other site 1199187003101 putative FPP binding hydrophobic cleft; other site 1199187003102 dimer interface [polypeptide binding]; other site 1199187003103 putative IPP diphosphate binding site; other site 1199187003104 pantothenate kinase; Provisional; Region: PRK05439 1199187003105 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1199187003106 ATP-binding site [chemical binding]; other site 1199187003107 CoA-binding site [chemical binding]; other site 1199187003108 Mg2+-binding site [ion binding]; other site 1199187003109 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1199187003110 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1199187003111 dimer interface [polypeptide binding]; other site 1199187003112 active site 1199187003113 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1199187003114 folate binding site [chemical binding]; other site 1199187003115 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1199187003116 dinuclear metal binding motif [ion binding]; other site 1199187003117 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1199187003118 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1199187003119 putative active site [active] 1199187003120 PhoH-like protein; Region: PhoH; pfam02562 1199187003121 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1199187003122 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1199187003123 NodB motif; other site 1199187003124 active site 1199187003125 catalytic site [active] 1199187003126 metal binding site [ion binding]; metal-binding site 1199187003127 HAMP domain; Region: HAMP; pfam00672 1199187003128 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1199187003129 cyclase homology domain; Region: CHD; cd07302 1199187003130 nucleotidyl binding site; other site 1199187003131 metal binding site [ion binding]; metal-binding site 1199187003132 dimer interface [polypeptide binding]; other site 1199187003133 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1199187003134 Class II fumarases; Region: Fumarase_classII; cd01362 1199187003135 active site 1199187003136 tetramer interface [polypeptide binding]; other site 1199187003137 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1199187003138 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1199187003139 putative active site [active] 1199187003140 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1199187003141 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1199187003142 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1199187003143 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187003144 substrate binding pocket [chemical binding]; other site 1199187003145 catalytic triad [active] 1199187003146 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1199187003147 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1199187003148 putative NAD(P) binding site [chemical binding]; other site 1199187003149 active site 1199187003150 putative substrate binding site [chemical binding]; other site 1199187003151 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1199187003152 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1199187003153 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1199187003154 generic binding surface II; other site 1199187003155 generic binding surface I; other site 1199187003156 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1199187003157 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1199187003158 GTP-binding protein YchF; Reviewed; Region: PRK09601 1199187003159 YchF GTPase; Region: YchF; cd01900 1199187003160 G1 box; other site 1199187003161 GTP/Mg2+ binding site [chemical binding]; other site 1199187003162 Switch I region; other site 1199187003163 G2 box; other site 1199187003164 Switch II region; other site 1199187003165 G3 box; other site 1199187003166 G4 box; other site 1199187003167 G5 box; other site 1199187003168 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1199187003169 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187003170 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1199187003171 active site 1199187003172 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1199187003173 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1199187003174 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187003175 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1199187003176 active site 1199187003177 metal binding site [ion binding]; metal-binding site 1199187003178 NlpC/P60 family; Region: NLPC_P60; cl17555 1199187003179 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1199187003180 cyclase homology domain; Region: CHD; cd07302 1199187003181 nucleotidyl binding site; other site 1199187003182 metal binding site [ion binding]; metal-binding site 1199187003183 dimer interface [polypeptide binding]; other site 1199187003184 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1199187003185 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1199187003186 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1199187003187 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1199187003188 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1199187003189 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187003190 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187003191 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1199187003192 dimer interface [polypeptide binding]; other site 1199187003193 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187003194 FeoC like transcriptional regulator; Region: FeoC; cl17677 1199187003195 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1199187003196 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1199187003197 Predicted membrane protein [Function unknown]; Region: COG2259 1199187003198 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1199187003199 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1199187003200 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1199187003201 THF binding site; other site 1199187003202 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1199187003203 substrate binding site [chemical binding]; other site 1199187003204 THF binding site; other site 1199187003205 zinc-binding site [ion binding]; other site 1199187003206 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1199187003207 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1199187003208 NAD(P) binding site [chemical binding]; other site 1199187003209 putative active site [active] 1199187003210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187003211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187003212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187003213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187003214 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1199187003215 FMN binding site [chemical binding]; other site 1199187003216 dimer interface [polypeptide binding]; other site 1199187003217 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187003218 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187003219 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187003220 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1199187003221 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187003222 active site 1199187003223 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1199187003224 metal ion-dependent adhesion site (MIDAS); other site 1199187003225 MoxR-like ATPases [General function prediction only]; Region: COG0714 1199187003226 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1199187003227 Walker A motif; other site 1199187003228 ATP binding site [chemical binding]; other site 1199187003229 Walker B motif; other site 1199187003230 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1199187003231 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1199187003232 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1199187003233 ligand binding site [chemical binding]; other site 1199187003234 short chain dehydrogenase; Provisional; Region: PRK06179 1199187003235 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1199187003236 NADP binding site [chemical binding]; other site 1199187003237 active site 1199187003238 steroid binding site; other site 1199187003239 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187003240 Cytochrome P450; Region: p450; cl12078 1199187003241 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1199187003242 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187003243 dimer interface [polypeptide binding]; other site 1199187003244 active site 1199187003245 enoyl-CoA hydratase; Provisional; Region: PRK08252 1199187003246 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187003247 substrate binding site [chemical binding]; other site 1199187003248 oxyanion hole (OAH) forming residues; other site 1199187003249 trimer interface [polypeptide binding]; other site 1199187003250 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1199187003251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1199187003252 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1199187003253 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1199187003254 malonyl-CoA binding site [chemical binding]; other site 1199187003255 dimer interface [polypeptide binding]; other site 1199187003256 active site 1199187003257 product binding site; other site 1199187003258 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1199187003259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187003260 NAD(P) binding site [chemical binding]; other site 1199187003261 active site 1199187003262 CAAX protease self-immunity; Region: Abi; pfam02517 1199187003263 enoyl-CoA hydratase; Provisional; Region: PRK06688 1199187003264 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187003265 substrate binding site [chemical binding]; other site 1199187003266 oxyanion hole (OAH) forming residues; other site 1199187003267 trimer interface [polypeptide binding]; other site 1199187003268 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187003269 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187003270 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1199187003271 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1199187003272 NAD binding site [chemical binding]; other site 1199187003273 homodimer interface [polypeptide binding]; other site 1199187003274 homotetramer interface [polypeptide binding]; other site 1199187003275 active site 1199187003276 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1199187003277 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1199187003278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187003279 S-adenosylmethionine binding site [chemical binding]; other site 1199187003280 NAD-dependent deacetylase; Provisional; Region: PRK00481 1199187003281 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1199187003282 NAD+ binding site [chemical binding]; other site 1199187003283 substrate binding site [chemical binding]; other site 1199187003284 Zn binding site [ion binding]; other site 1199187003285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187003286 DNA-binding site [nucleotide binding]; DNA binding site 1199187003287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1199187003288 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1199187003289 uncharacterized HhH-GPD family protein; Region: TIGR03252 1199187003290 minor groove reading motif; other site 1199187003291 helix-hairpin-helix signature motif; other site 1199187003292 mannosyltransferase; Provisional; Region: pimE; PRK13375 1199187003293 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1199187003294 aromatic arch; other site 1199187003295 DCoH dimer interaction site [polypeptide binding]; other site 1199187003296 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1199187003297 DCoH tetramer interaction site [polypeptide binding]; other site 1199187003298 substrate binding site [chemical binding]; other site 1199187003299 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1199187003300 active site 1199187003301 8-oxo-dGMP binding site [chemical binding]; other site 1199187003302 nudix motif; other site 1199187003303 metal binding site [ion binding]; metal-binding site 1199187003304 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1199187003305 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1199187003306 [4Fe-4S] binding site [ion binding]; other site 1199187003307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187003308 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187003309 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187003310 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1199187003311 molybdopterin cofactor binding site; other site 1199187003312 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1199187003313 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1199187003314 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1199187003315 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1199187003316 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1199187003317 G1 box; other site 1199187003318 putative GEF interaction site [polypeptide binding]; other site 1199187003319 GTP/Mg2+ binding site [chemical binding]; other site 1199187003320 Switch I region; other site 1199187003321 G2 box; other site 1199187003322 G3 box; other site 1199187003323 Switch II region; other site 1199187003324 G4 box; other site 1199187003325 G5 box; other site 1199187003326 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1199187003327 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1199187003328 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1199187003329 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1199187003330 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1199187003331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187003332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187003333 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1199187003334 FO synthase; Reviewed; Region: fbiC; PRK09234 1199187003335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1199187003336 FeS/SAM binding site; other site 1199187003337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1199187003338 FeS/SAM binding site; other site 1199187003339 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1199187003340 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1199187003341 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187003342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187003343 Integrase core domain; Region: rve; pfam00665 1199187003344 Integrase core domain; Region: rve_3; pfam13683 1199187003345 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1199187003346 4Fe-4S binding domain; Region: Fer4; pfam00037 1199187003347 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1199187003348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187003349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187003350 homodimer interface [polypeptide binding]; other site 1199187003351 catalytic residue [active] 1199187003352 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1199187003353 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1199187003354 generic binding surface II; other site 1199187003355 ssDNA binding site; other site 1199187003356 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187003357 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1199187003358 active site 1199187003359 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187003360 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1199187003361 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1199187003362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187003363 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1199187003364 Enoylreductase; Region: PKS_ER; smart00829 1199187003365 NAD(P) binding site [chemical binding]; other site 1199187003366 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1199187003367 KR domain; Region: KR; pfam08659 1199187003368 putative NADP binding site [chemical binding]; other site 1199187003369 active site 1199187003370 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187003371 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1199187003372 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187003373 PPE family; Region: PPE; pfam00823 1199187003374 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187003375 PPE family; Region: PPE; pfam00823 1199187003376 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187003377 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1199187003378 ligand-binding site [chemical binding]; other site 1199187003379 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1199187003380 ATP-sulfurylase; Region: ATPS; cd00517 1199187003381 active site 1199187003382 HXXH motif; other site 1199187003383 flexible loop; other site 1199187003384 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1199187003385 acyl-CoA synthetase; Validated; Region: PRK05850 1199187003386 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1199187003387 acyl-activating enzyme (AAE) consensus motif; other site 1199187003388 active site 1199187003389 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187003390 PPE family; Region: PPE; pfam00823 1199187003391 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1199187003392 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1199187003393 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1199187003394 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1199187003395 NAD(P) binding site [chemical binding]; other site 1199187003396 catalytic residues [active] 1199187003397 Proline dehydrogenase; Region: Pro_dh; cl03282 1199187003398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187003399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187003400 lipid-transfer protein; Provisional; Region: PRK07855 1199187003401 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187003402 active site 1199187003403 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1199187003404 putative active site [active] 1199187003405 putative catalytic site [active] 1199187003406 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187003407 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187003408 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1199187003409 active site 1199187003410 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1199187003411 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187003412 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1199187003413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187003414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187003415 active site 1199187003416 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187003417 Cytochrome P450; Region: p450; cl12078 1199187003418 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1199187003419 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1199187003420 NAD binding site [chemical binding]; other site 1199187003421 catalytic residues [active] 1199187003422 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187003423 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187003424 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187003425 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187003426 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187003427 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1199187003428 acyl-CoA synthetase; Validated; Region: PRK07787 1199187003429 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187003430 acyl-activating enzyme (AAE) consensus motif; other site 1199187003431 AMP binding site [chemical binding]; other site 1199187003432 active site 1199187003433 CoA binding site [chemical binding]; other site 1199187003434 metabolite-proton symporter; Region: 2A0106; TIGR00883 1199187003435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187003436 putative substrate translocation pore; other site 1199187003437 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1199187003438 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1199187003439 putative trimer interface [polypeptide binding]; other site 1199187003440 putative CoA binding site [chemical binding]; other site 1199187003441 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187003442 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187003443 PE family; Region: PE; pfam00934 1199187003444 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187003445 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187003446 PPE family; Region: PPE; pfam00823 1199187003447 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187003448 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1199187003449 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1199187003450 metal binding site [ion binding]; metal-binding site 1199187003451 putative dimer interface [polypeptide binding]; other site 1199187003452 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1199187003453 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1199187003454 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1199187003455 acyl-activating enzyme (AAE) consensus motif; other site 1199187003456 putative AMP binding site [chemical binding]; other site 1199187003457 putative active site [active] 1199187003458 putative CoA binding site [chemical binding]; other site 1199187003459 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1199187003460 dihydropteroate synthase; Region: DHPS; TIGR01496 1199187003461 substrate binding pocket [chemical binding]; other site 1199187003462 dimer interface [polypeptide binding]; other site 1199187003463 inhibitor binding site; inhibition site 1199187003464 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1199187003465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1199187003466 active site 1199187003467 DivIVA domain; Region: DivI1A_domain; TIGR03544 1199187003468 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1199187003469 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1199187003470 Transposase domain (DUF772); Region: DUF772; pfam05598 1199187003471 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1199187003472 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1199187003473 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1199187003474 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1199187003475 ligand binding site; other site 1199187003476 oligomer interface; other site 1199187003477 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1199187003478 dimer interface [polypeptide binding]; other site 1199187003479 N-terminal domain interface [polypeptide binding]; other site 1199187003480 sulfate 1 binding site; other site 1199187003481 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1199187003482 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1199187003483 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1199187003484 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1199187003485 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1199187003486 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1199187003487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187003488 Q-loop/lid; other site 1199187003489 ABC transporter signature motif; other site 1199187003490 Walker B; other site 1199187003491 D-loop; other site 1199187003492 H-loop/switch region; other site 1199187003493 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1199187003494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187003495 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1199187003496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187003497 S-adenosylmethionine binding site [chemical binding]; other site 1199187003498 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1199187003499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187003500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187003501 DNA binding residues [nucleotide binding] 1199187003502 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1199187003503 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1199187003504 protein binding site [polypeptide binding]; other site 1199187003505 sec-independent translocase; Provisional; Region: PRK03100 1199187003506 Domain of unknown function DUF59; Region: DUF59; cl00941 1199187003507 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1199187003508 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1199187003509 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1199187003510 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1199187003511 catalytic residue [active] 1199187003512 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1199187003513 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1199187003514 MgtE intracellular N domain; Region: MgtE_N; smart00924 1199187003515 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1199187003516 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1199187003517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1199187003518 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1199187003519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187003520 dimer interface [polypeptide binding]; other site 1199187003521 conserved gate region; other site 1199187003522 putative PBP binding loops; other site 1199187003523 ABC-ATPase subunit interface; other site 1199187003524 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1199187003525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187003526 dimer interface [polypeptide binding]; other site 1199187003527 conserved gate region; other site 1199187003528 ABC-ATPase subunit interface; other site 1199187003529 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1199187003530 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1199187003531 Walker A/P-loop; other site 1199187003532 ATP binding site [chemical binding]; other site 1199187003533 Q-loop/lid; other site 1199187003534 ABC transporter signature motif; other site 1199187003535 Walker B; other site 1199187003536 D-loop; other site 1199187003537 H-loop/switch region; other site 1199187003538 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1199187003539 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1199187003540 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1199187003541 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1199187003542 oligomer interface [polypeptide binding]; other site 1199187003543 metal binding site [ion binding]; metal-binding site 1199187003544 metal binding site [ion binding]; metal-binding site 1199187003545 putative Cl binding site [ion binding]; other site 1199187003546 basic sphincter; other site 1199187003547 hydrophobic gate; other site 1199187003548 periplasmic entrance; other site 1199187003549 malate dehydrogenase; Provisional; Region: PRK05442 1199187003550 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1199187003551 NAD(P) binding site [chemical binding]; other site 1199187003552 dimer interface [polypeptide binding]; other site 1199187003553 malate binding site [chemical binding]; other site 1199187003554 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1199187003555 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1199187003556 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1199187003557 putative NAD(P) binding site [chemical binding]; other site 1199187003558 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1199187003559 short chain dehydrogenase; Provisional; Region: PRK07832 1199187003560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187003561 NAD(P) binding site [chemical binding]; other site 1199187003562 active site 1199187003563 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1199187003564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187003565 NAD(P) binding site [chemical binding]; other site 1199187003566 active site 1199187003567 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1199187003568 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1199187003569 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1199187003570 TPP-binding site [chemical binding]; other site 1199187003571 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1199187003572 dimer interface [polypeptide binding]; other site 1199187003573 PYR/PP interface [polypeptide binding]; other site 1199187003574 TPP binding site [chemical binding]; other site 1199187003575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187003576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1199187003577 putative substrate translocation pore; other site 1199187003578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187003579 putative substrate translocation pore; other site 1199187003580 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1199187003581 RNase_H superfamily; Region: RNase_H_2; pfam13482 1199187003582 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1199187003583 Part of AAA domain; Region: AAA_19; pfam13245 1199187003584 AAA domain; Region: AAA_12; pfam13087 1199187003585 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187003586 SnoaL-like domain; Region: SnoaL_4; pfam13577 1199187003587 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187003588 classical (c) SDRs; Region: SDR_c; cd05233 1199187003589 NAD(P) binding site [chemical binding]; other site 1199187003590 active site 1199187003591 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187003592 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187003593 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187003594 classical (c) SDRs; Region: SDR_c; cd05233 1199187003595 NAD(P) binding site [chemical binding]; other site 1199187003596 active site 1199187003597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187003598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187003599 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187003600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187003601 NAD(P) binding site [chemical binding]; other site 1199187003602 active site 1199187003603 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1199187003604 Cytochrome P450; Region: p450; cl12078 1199187003605 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187003606 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187003607 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1199187003608 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187003609 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1199187003610 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1199187003611 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1199187003612 ATP binding site [chemical binding]; other site 1199187003613 Mg++ binding site [ion binding]; other site 1199187003614 motif III; other site 1199187003615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187003616 nucleotide binding region [chemical binding]; other site 1199187003617 ATP-binding site [chemical binding]; other site 1199187003618 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1199187003619 putative RNA binding site [nucleotide binding]; other site 1199187003620 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1199187003621 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1199187003622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187003623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187003624 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187003625 Cytochrome P450; Region: p450; cl12078 1199187003626 FAD binding domain; Region: FAD_binding_4; pfam01565 1199187003627 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1199187003628 H+ Antiporter protein; Region: 2A0121; TIGR00900 1199187003629 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1199187003630 Fe-S cluster binding site [ion binding]; other site 1199187003631 DNA binding site [nucleotide binding] 1199187003632 active site 1199187003633 hypothetical protein; Validated; Region: PRK05868 1199187003634 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1199187003635 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1199187003636 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187003637 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1199187003638 HIT family signature motif; other site 1199187003639 catalytic residue [active] 1199187003640 amidase; Provisional; Region: PRK12470 1199187003641 Amidase; Region: Amidase; cl11426 1199187003642 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1199187003643 putative active site [active] 1199187003644 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1199187003645 cyclase homology domain; Region: CHD; cd07302 1199187003646 nucleotidyl binding site; other site 1199187003647 metal binding site [ion binding]; metal-binding site 1199187003648 dimer interface [polypeptide binding]; other site 1199187003649 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1199187003650 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1199187003651 DNA binding site [nucleotide binding] 1199187003652 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187003653 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187003654 phosphopeptide binding site; other site 1199187003655 Transposase domain (DUF772); Region: DUF772; pfam05598 1199187003656 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187003657 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1199187003658 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1199187003659 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1199187003660 Walker A/P-loop; other site 1199187003661 ATP binding site [chemical binding]; other site 1199187003662 Q-loop/lid; other site 1199187003663 ABC transporter signature motif; other site 1199187003664 Walker B; other site 1199187003665 D-loop; other site 1199187003666 H-loop/switch region; other site 1199187003667 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1199187003668 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1199187003669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187003670 Walker A/P-loop; other site 1199187003671 ATP binding site [chemical binding]; other site 1199187003672 Q-loop/lid; other site 1199187003673 ABC transporter signature motif; other site 1199187003674 Walker B; other site 1199187003675 D-loop; other site 1199187003676 H-loop/switch region; other site 1199187003677 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1199187003678 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1199187003679 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187003680 catalytic core [active] 1199187003681 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187003682 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187003683 active site 1199187003684 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1199187003685 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1199187003686 active site 1199187003687 metal binding site [ion binding]; metal-binding site 1199187003688 DNA binding site [nucleotide binding] 1199187003689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187003690 Walker A/P-loop; other site 1199187003691 ATP binding site [chemical binding]; other site 1199187003692 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187003693 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1199187003694 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1199187003695 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1199187003696 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1199187003697 Walker A/P-loop; other site 1199187003698 ATP binding site [chemical binding]; other site 1199187003699 Q-loop/lid; other site 1199187003700 ABC transporter signature motif; other site 1199187003701 Walker B; other site 1199187003702 D-loop; other site 1199187003703 H-loop/switch region; other site 1199187003704 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1199187003705 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1199187003706 Walker A/P-loop; other site 1199187003707 ATP binding site [chemical binding]; other site 1199187003708 Q-loop/lid; other site 1199187003709 ABC transporter signature motif; other site 1199187003710 Walker B; other site 1199187003711 D-loop; other site 1199187003712 H-loop/switch region; other site 1199187003713 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1199187003714 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1199187003715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187003716 dimer interface [polypeptide binding]; other site 1199187003717 conserved gate region; other site 1199187003718 putative PBP binding loops; other site 1199187003719 ABC-ATPase subunit interface; other site 1199187003720 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1199187003721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187003722 dimer interface [polypeptide binding]; other site 1199187003723 conserved gate region; other site 1199187003724 putative PBP binding loops; other site 1199187003725 ABC-ATPase subunit interface; other site 1199187003726 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1199187003727 active site clefts [active] 1199187003728 zinc binding site [ion binding]; other site 1199187003729 dimer interface [polypeptide binding]; other site 1199187003730 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187003731 CoenzymeA binding site [chemical binding]; other site 1199187003732 subunit interaction site [polypeptide binding]; other site 1199187003733 PHB binding site; other site 1199187003734 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1199187003735 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1199187003736 Active Sites [active] 1199187003737 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1199187003738 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1199187003739 G1 box; other site 1199187003740 putative GEF interaction site [polypeptide binding]; other site 1199187003741 GTP/Mg2+ binding site [chemical binding]; other site 1199187003742 Switch I region; other site 1199187003743 G2 box; other site 1199187003744 CysD dimerization site [polypeptide binding]; other site 1199187003745 G3 box; other site 1199187003746 Switch II region; other site 1199187003747 G4 box; other site 1199187003748 G5 box; other site 1199187003749 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1199187003750 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1199187003751 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1199187003752 ligand-binding site [chemical binding]; other site 1199187003753 Rrf2 family protein; Region: rrf2_super; TIGR00738 1199187003754 Transcriptional regulator; Region: Rrf2; pfam02082 1199187003755 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 1199187003756 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187003757 metal binding site [ion binding]; metal-binding site 1199187003758 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1199187003759 putative dimer interface [polypeptide binding]; other site 1199187003760 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187003761 ligand binding site [chemical binding]; other site 1199187003762 Zn binding site [ion binding]; other site 1199187003763 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187003764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1199187003765 TrkA-N domain; Region: TrkA_N; pfam02254 1199187003766 Ion channel; Region: Ion_trans_2; pfam07885 1199187003767 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1199187003768 TrkA-N domain; Region: TrkA_N; pfam02254 1199187003769 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1199187003770 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1199187003771 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1199187003772 dimer interface [polypeptide binding]; other site 1199187003773 ADP-ribose binding site [chemical binding]; other site 1199187003774 active site 1199187003775 nudix motif; other site 1199187003776 metal binding site [ion binding]; metal-binding site 1199187003777 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187003778 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1199187003779 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1199187003780 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1199187003781 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1199187003782 active site 1199187003783 HIGH motif; other site 1199187003784 KMSK motif region; other site 1199187003785 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1199187003786 tRNA binding surface [nucleotide binding]; other site 1199187003787 anticodon binding site; other site 1199187003788 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1199187003789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1199187003790 active site 1199187003791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1199187003792 substrate binding site [chemical binding]; other site 1199187003793 catalytic residues [active] 1199187003794 dimer interface [polypeptide binding]; other site 1199187003795 homoserine dehydrogenase; Provisional; Region: PRK06349 1199187003796 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1199187003797 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1199187003798 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1199187003799 threonine synthase; Reviewed; Region: PRK06721 1199187003800 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1199187003801 homodimer interface [polypeptide binding]; other site 1199187003802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187003803 catalytic residue [active] 1199187003804 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1199187003805 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1199187003806 transcription termination factor Rho; Provisional; Region: PRK12608 1199187003807 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1199187003808 RNA binding site [nucleotide binding]; other site 1199187003809 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1199187003810 multimer interface [polypeptide binding]; other site 1199187003811 Walker A motif; other site 1199187003812 ATP binding site [chemical binding]; other site 1199187003813 Walker B motif; other site 1199187003814 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1199187003815 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1199187003816 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1199187003817 RF-1 domain; Region: RF-1; pfam00472 1199187003818 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1199187003819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187003820 S-adenosylmethionine binding site [chemical binding]; other site 1199187003821 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1199187003822 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1199187003823 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1199187003824 Mg++ binding site [ion binding]; other site 1199187003825 putative catalytic motif [active] 1199187003826 substrate binding site [chemical binding]; other site 1199187003827 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1199187003828 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1199187003829 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1199187003830 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1199187003831 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1199187003832 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1199187003833 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1199187003834 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1199187003835 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1199187003836 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1199187003837 beta subunit interaction interface [polypeptide binding]; other site 1199187003838 Walker A motif; other site 1199187003839 ATP binding site [chemical binding]; other site 1199187003840 Walker B motif; other site 1199187003841 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1199187003842 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1199187003843 core domain interface [polypeptide binding]; other site 1199187003844 delta subunit interface [polypeptide binding]; other site 1199187003845 epsilon subunit interface [polypeptide binding]; other site 1199187003846 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1199187003847 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1199187003848 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1199187003849 alpha subunit interaction interface [polypeptide binding]; other site 1199187003850 Walker A motif; other site 1199187003851 ATP binding site [chemical binding]; other site 1199187003852 Walker B motif; other site 1199187003853 inhibitor binding site; inhibition site 1199187003854 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1199187003855 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1199187003856 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1199187003857 gamma subunit interface [polypeptide binding]; other site 1199187003858 epsilon subunit interface [polypeptide binding]; other site 1199187003859 LBP interface [polypeptide binding]; other site 1199187003860 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1199187003861 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1199187003862 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1199187003863 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1199187003864 hinge; other site 1199187003865 active site 1199187003866 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1199187003867 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1199187003868 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1199187003869 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1199187003870 DNA binding site [nucleotide binding] 1199187003871 active site 1199187003872 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187003873 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187003874 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1199187003875 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1199187003876 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1199187003877 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1199187003878 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1199187003879 minor groove reading motif; other site 1199187003880 helix-hairpin-helix signature motif; other site 1199187003881 substrate binding pocket [chemical binding]; other site 1199187003882 active site 1199187003883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1199187003884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1199187003885 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1199187003886 putative dimerization interface [polypeptide binding]; other site 1199187003887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187003888 putative substrate translocation pore; other site 1199187003889 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1199187003890 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1199187003891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187003892 dimerization interface [polypeptide binding]; other site 1199187003893 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1199187003894 cyclase homology domain; Region: CHD; cd07302 1199187003895 nucleotidyl binding site; other site 1199187003896 metal binding site [ion binding]; metal-binding site 1199187003897 dimer interface [polypeptide binding]; other site 1199187003898 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1199187003899 hypothetical protein; Provisional; Region: PRK03298 1199187003900 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1199187003901 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187003902 dimer interface [polypeptide binding]; other site 1199187003903 substrate binding site [chemical binding]; other site 1199187003904 metal binding site [ion binding]; metal-binding site 1199187003905 putative acyltransferase; Provisional; Region: PRK05790 1199187003906 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187003907 dimer interface [polypeptide binding]; other site 1199187003908 active site 1199187003909 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1199187003910 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1199187003911 glycogen branching enzyme; Provisional; Region: PRK05402 1199187003912 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1199187003913 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1199187003914 active site 1199187003915 catalytic site [active] 1199187003916 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1199187003917 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1199187003918 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1199187003919 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1199187003920 active site 1199187003921 homodimer interface [polypeptide binding]; other site 1199187003922 catalytic site [active] 1199187003923 acceptor binding site [chemical binding]; other site 1199187003924 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1199187003925 putative homodimer interface [polypeptide binding]; other site 1199187003926 putative active site pocket [active] 1199187003927 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1199187003928 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1199187003929 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1199187003930 ATP binding site [chemical binding]; other site 1199187003931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187003932 putative Mg++ binding site [ion binding]; other site 1199187003933 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1199187003934 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1199187003935 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1199187003936 active site 1199187003937 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1199187003938 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1199187003939 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1199187003940 putative active site pocket [active] 1199187003941 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 1199187003942 glutamate racemase; Provisional; Region: PRK00865 1199187003943 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1199187003944 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1199187003945 ribonuclease PH; Reviewed; Region: rph; PRK00173 1199187003946 hexamer interface [polypeptide binding]; other site 1199187003947 active site 1199187003948 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1199187003949 active site 1199187003950 dimerization interface [polypeptide binding]; other site 1199187003951 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1199187003952 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1199187003953 Transposase domain (DUF772); Region: DUF772; pfam05598 1199187003954 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1199187003955 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1199187003956 FAD binding pocket [chemical binding]; other site 1199187003957 FAD binding motif [chemical binding]; other site 1199187003958 phosphate binding motif [ion binding]; other site 1199187003959 NAD binding pocket [chemical binding]; other site 1199187003960 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1199187003961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187003962 Walker A/P-loop; other site 1199187003963 ATP binding site [chemical binding]; other site 1199187003964 Q-loop/lid; other site 1199187003965 ABC transporter signature motif; other site 1199187003966 Walker B; other site 1199187003967 D-loop; other site 1199187003968 H-loop/switch region; other site 1199187003969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187003970 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1199187003971 Walker A/P-loop; other site 1199187003972 ATP binding site [chemical binding]; other site 1199187003973 Q-loop/lid; other site 1199187003974 ABC transporter signature motif; other site 1199187003975 Walker B; other site 1199187003976 D-loop; other site 1199187003977 H-loop/switch region; other site 1199187003978 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187003979 Ecdysteroid kinase; Region: EcKinase; cl17738 1199187003980 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1199187003981 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187003982 classical (c) SDRs; Region: SDR_c; cd05233 1199187003983 NAD(P) binding site [chemical binding]; other site 1199187003984 active site 1199187003985 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187003986 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187003987 active site 1199187003988 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187003989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187003990 NAD(P) binding site [chemical binding]; other site 1199187003991 active site 1199187003992 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1199187003993 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187003994 dimer interface [polypeptide binding]; other site 1199187003995 active site 1199187003996 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1199187003997 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187003998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187003999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004000 active site 1199187004001 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1199187004002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187004003 DNA-binding site [nucleotide binding]; DNA binding site 1199187004004 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1199187004005 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1199187004006 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004007 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004008 acyl-activating enzyme (AAE) consensus motif; other site 1199187004009 acyl-activating enzyme (AAE) consensus motif; other site 1199187004010 AMP binding site [chemical binding]; other site 1199187004011 active site 1199187004012 CoA binding site [chemical binding]; other site 1199187004013 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1199187004014 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004015 acyl-activating enzyme (AAE) consensus motif; other site 1199187004016 AMP binding site [chemical binding]; other site 1199187004017 active site 1199187004018 CoA binding site [chemical binding]; other site 1199187004019 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1199187004020 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004021 acyl-activating enzyme (AAE) consensus motif; other site 1199187004022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004023 AMP binding site [chemical binding]; other site 1199187004024 active site 1199187004025 acyl-activating enzyme (AAE) consensus motif; other site 1199187004026 CoA binding site [chemical binding]; other site 1199187004027 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187004028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187004029 substrate binding site [chemical binding]; other site 1199187004030 oxyanion hole (OAH) forming residues; other site 1199187004031 trimer interface [polypeptide binding]; other site 1199187004032 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187004033 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187004034 substrate binding site [chemical binding]; other site 1199187004035 oxyanion hole (OAH) forming residues; other site 1199187004036 trimer interface [polypeptide binding]; other site 1199187004037 enoyl-CoA hydratase; Provisional; Region: PRK06688 1199187004038 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187004039 substrate binding site [chemical binding]; other site 1199187004040 oxyanion hole (OAH) forming residues; other site 1199187004041 trimer interface [polypeptide binding]; other site 1199187004042 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187004043 CoenzymeA binding site [chemical binding]; other site 1199187004044 subunit interaction site [polypeptide binding]; other site 1199187004045 PHB binding site; other site 1199187004046 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187004047 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1199187004048 substrate binding site [chemical binding]; other site 1199187004049 oxyanion hole (OAH) forming residues; other site 1199187004050 trimer interface [polypeptide binding]; other site 1199187004051 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1199187004052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187004053 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1199187004054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187004055 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187004056 NAD(P) binding site [chemical binding]; other site 1199187004057 active site 1199187004058 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1199187004059 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1199187004060 active site 1199187004061 inhibitor site; inhibition site 1199187004062 dimer interface [polypeptide binding]; other site 1199187004063 catalytic residue [active] 1199187004064 enoyl-CoA hydratase; Provisional; Region: PRK06210 1199187004065 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187004066 substrate binding site [chemical binding]; other site 1199187004067 oxyanion hole (OAH) forming residues; other site 1199187004068 trimer interface [polypeptide binding]; other site 1199187004069 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187004070 acyl-CoA synthetase; Validated; Region: PRK07798 1199187004071 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004072 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1199187004073 acyl-activating enzyme (AAE) consensus motif; other site 1199187004074 acyl-activating enzyme (AAE) consensus motif; other site 1199187004075 putative AMP binding site [chemical binding]; other site 1199187004076 putative active site [active] 1199187004077 putative CoA binding site [chemical binding]; other site 1199187004078 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187004079 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187004080 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187004081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187004083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004084 active site 1199187004085 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1199187004086 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187004087 active site 1199187004088 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187004089 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187004090 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187004091 Cytochrome P450; Region: p450; cl12078 1199187004092 classical (c) SDRs; Region: SDR_c; cd05233 1199187004093 NAD(P) binding site [chemical binding]; other site 1199187004094 active site 1199187004095 acyl-CoA synthetase; Validated; Region: PRK07798 1199187004096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004097 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1199187004098 acyl-activating enzyme (AAE) consensus motif; other site 1199187004099 acyl-activating enzyme (AAE) consensus motif; other site 1199187004100 putative AMP binding site [chemical binding]; other site 1199187004101 putative active site [active] 1199187004102 putative CoA binding site [chemical binding]; other site 1199187004103 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187004104 CoenzymeA binding site [chemical binding]; other site 1199187004105 subunit interaction site [polypeptide binding]; other site 1199187004106 PHB binding site; other site 1199187004107 Isochorismatase family; Region: Isochorismatase; pfam00857 1199187004108 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1199187004109 catalytic triad [active] 1199187004110 conserved cis-peptide bond; other site 1199187004111 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187004112 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187004113 [2Fe-2S] cluster binding site [ion binding]; other site 1199187004114 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187004115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187004116 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187004117 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1199187004118 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187004119 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1199187004120 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187004121 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187004122 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1199187004123 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1199187004124 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1199187004125 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187004126 Cytochrome P450; Region: p450; cl12078 1199187004127 short chain dehydrogenase; Provisional; Region: PRK06197 1199187004128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187004129 NAD(P) binding site [chemical binding]; other site 1199187004130 active site 1199187004131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187004132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187004133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187004134 Walker A/P-loop; other site 1199187004135 ATP binding site [chemical binding]; other site 1199187004136 Predicted membrane protein [Function unknown]; Region: COG1511 1199187004137 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1199187004138 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1199187004139 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1199187004140 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1199187004141 NAD binding site [chemical binding]; other site 1199187004142 catalytic Zn binding site [ion binding]; other site 1199187004143 substrate binding site [chemical binding]; other site 1199187004144 structural Zn binding site [ion binding]; other site 1199187004145 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187004146 Cytochrome P450; Region: p450; cl12078 1199187004147 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187004148 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187004149 substrate binding pocket [chemical binding]; other site 1199187004150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187004151 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187004152 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1199187004153 active site 1199187004154 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187004155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004156 active site 1199187004157 PAS fold; Region: PAS_4; pfam08448 1199187004158 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1199187004159 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1199187004160 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1199187004161 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1199187004162 ATP binding site [chemical binding]; other site 1199187004163 Mg2+ binding site [ion binding]; other site 1199187004164 G-X-G motif; other site 1199187004165 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1199187004166 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1199187004167 Moco binding site; other site 1199187004168 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1199187004169 metal coordination site [ion binding]; other site 1199187004170 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187004171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187004172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187004173 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187004174 CoenzymeA binding site [chemical binding]; other site 1199187004175 subunit interaction site [polypeptide binding]; other site 1199187004176 PHB binding site; other site 1199187004177 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187004178 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1199187004179 active site 1199187004180 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187004181 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004182 active site 1199187004183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187004184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004185 active site 1199187004186 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1199187004187 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187004188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004189 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187004190 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187004191 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 1199187004192 classical (c) SDRs; Region: SDR_c; cd05233 1199187004193 NAD(P) binding site [chemical binding]; other site 1199187004194 active site 1199187004195 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1199187004196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187004197 DNA-binding site [nucleotide binding]; DNA binding site 1199187004198 FCD domain; Region: FCD; pfam07729 1199187004199 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187004200 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187004201 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187004202 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187004203 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1199187004204 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1199187004205 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187004206 Cytochrome P450; Region: p450; cl12078 1199187004207 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187004208 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187004209 [2Fe-2S] cluster binding site [ion binding]; other site 1199187004210 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1199187004211 hydrophobic ligand binding site; other site 1199187004212 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1199187004213 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1199187004214 acyl-activating enzyme (AAE) consensus motif; other site 1199187004215 putative AMP binding site [chemical binding]; other site 1199187004216 putative active site [active] 1199187004217 putative CoA binding site [chemical binding]; other site 1199187004218 SnoaL-like domain; Region: SnoaL_4; pfam13577 1199187004219 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1199187004220 active site 1199187004221 catalytic site [active] 1199187004222 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1199187004223 putative active site [active] 1199187004224 putative catalytic site [active] 1199187004225 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1199187004226 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1199187004227 NAD binding site [chemical binding]; other site 1199187004228 catalytic residues [active] 1199187004229 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1199187004230 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187004231 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187004232 [2Fe-2S] cluster binding site [ion binding]; other site 1199187004233 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 1199187004234 putative alpha subunit interface [polypeptide binding]; other site 1199187004235 putative active site [active] 1199187004236 putative substrate binding site [chemical binding]; other site 1199187004237 Fe binding site [ion binding]; other site 1199187004238 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1199187004239 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1199187004240 DNA binding residues [nucleotide binding] 1199187004241 dimer interface [polypeptide binding]; other site 1199187004242 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1199187004243 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1199187004244 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1199187004245 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1199187004246 phosphate binding site [ion binding]; other site 1199187004247 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1199187004248 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1199187004249 putative active site [active] 1199187004250 putative catalytic site [active] 1199187004251 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1199187004252 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1199187004253 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1199187004254 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1199187004255 putative NAD(P) binding site [chemical binding]; other site 1199187004256 active site 1199187004257 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1199187004258 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1199187004259 active site 1199187004260 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1199187004261 hypothetical protein; Provisional; Region: PRK07907 1199187004262 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1199187004263 active site 1199187004264 metal binding site [ion binding]; metal-binding site 1199187004265 dimer interface [polypeptide binding]; other site 1199187004266 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1199187004267 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1199187004268 catalytic triad [active] 1199187004269 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1199187004270 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1199187004271 hypothetical protein; Provisional; Region: PRK01346 1199187004272 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1199187004273 MMPL family; Region: MMPL; pfam03176 1199187004274 MMPL family; Region: MMPL; pfam03176 1199187004275 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1199187004276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1199187004277 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1199187004278 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1199187004279 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1199187004280 catalytic site [active] 1199187004281 putative active site [active] 1199187004282 putative substrate binding site [chemical binding]; other site 1199187004283 dimer interface [polypeptide binding]; other site 1199187004284 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1199187004285 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1199187004286 classical (c) SDRs; Region: SDR_c; cd05233 1199187004287 NAD(P) binding site [chemical binding]; other site 1199187004288 active site 1199187004289 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1199187004290 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187004291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187004292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187004293 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1199187004294 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1199187004295 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1199187004296 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1199187004297 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1199187004298 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1199187004299 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1199187004300 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1199187004301 carboxyltransferase (CT) interaction site; other site 1199187004302 biotinylation site [posttranslational modification]; other site 1199187004303 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187004304 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004305 active site 1199187004306 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1199187004307 putative active site [active] 1199187004308 putative catalytic site [active] 1199187004309 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1199187004310 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1199187004311 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1199187004312 tetramer interface [polypeptide binding]; other site 1199187004313 TPP-binding site [chemical binding]; other site 1199187004314 heterodimer interface [polypeptide binding]; other site 1199187004315 phosphorylation loop region [posttranslational modification] 1199187004316 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1199187004317 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1199187004318 alpha subunit interface [polypeptide binding]; other site 1199187004319 TPP binding site [chemical binding]; other site 1199187004320 heterodimer interface [polypeptide binding]; other site 1199187004321 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1199187004322 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1199187004323 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1199187004324 E3 interaction surface; other site 1199187004325 lipoyl attachment site [posttranslational modification]; other site 1199187004326 e3 binding domain; Region: E3_binding; pfam02817 1199187004327 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1199187004328 enoyl-CoA hydratase; Provisional; Region: PRK05870 1199187004329 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187004330 substrate binding site [chemical binding]; other site 1199187004331 oxyanion hole (OAH) forming residues; other site 1199187004332 trimer interface [polypeptide binding]; other site 1199187004333 Cutinase; Region: Cutinase; pfam01083 1199187004334 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1199187004335 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187004336 DNA-binding interface [nucleotide binding]; DNA binding site 1199187004337 Homeodomain-like domain; Region: HTH_32; pfam13565 1199187004338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187004339 Integrase core domain; Region: rve; pfam00665 1199187004340 Integrase core domain; Region: rve_3; pfam13683 1199187004341 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1199187004342 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187004343 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187004344 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1199187004345 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1199187004346 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1199187004347 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187004348 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1199187004349 putative acyl-acceptor binding pocket; other site 1199187004350 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1199187004351 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1199187004352 putative acyl-acceptor binding pocket; other site 1199187004353 Copper resistance protein D; Region: CopD; pfam05425 1199187004354 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1199187004355 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1199187004356 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1199187004357 dimer interface [polypeptide binding]; other site 1199187004358 ssDNA binding site [nucleotide binding]; other site 1199187004359 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1199187004360 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1199187004361 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1199187004362 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1199187004363 ABC transporter; Region: ABC_tran_2; pfam12848 1199187004364 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1199187004365 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1199187004366 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1199187004367 active site 1199187004368 catalytic site [active] 1199187004369 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1199187004370 apolar tunnel; other site 1199187004371 heme binding site [chemical binding]; other site 1199187004372 dimerization interface [polypeptide binding]; other site 1199187004373 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1199187004374 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187004375 active site 1199187004376 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1199187004377 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1199187004378 Zn binding site [ion binding]; other site 1199187004379 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1199187004380 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1199187004381 catalytic residues [active] 1199187004382 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1199187004383 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1199187004384 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1199187004385 putative DNA binding site [nucleotide binding]; other site 1199187004386 catalytic residue [active] 1199187004387 putative H2TH interface [polypeptide binding]; other site 1199187004388 putative catalytic residues [active] 1199187004389 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1199187004390 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1199187004391 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1199187004392 Beta-lactamase; Region: Beta-lactamase; pfam00144 1199187004393 trigger factor; Provisional; Region: tig; PRK01490 1199187004394 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1199187004395 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1199187004396 Clp protease; Region: CLP_protease; pfam00574 1199187004397 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1199187004398 oligomer interface [polypeptide binding]; other site 1199187004399 active site residues [active] 1199187004400 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1199187004401 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1199187004402 oligomer interface [polypeptide binding]; other site 1199187004403 active site residues [active] 1199187004404 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1199187004405 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1199187004406 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1199187004407 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1199187004408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187004409 Walker A motif; other site 1199187004410 ATP binding site [chemical binding]; other site 1199187004411 Walker B motif; other site 1199187004412 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1199187004413 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1199187004414 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1199187004415 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1199187004416 dimer interface [polypeptide binding]; other site 1199187004417 PYR/PP interface [polypeptide binding]; other site 1199187004418 TPP binding site [chemical binding]; other site 1199187004419 substrate binding site [chemical binding]; other site 1199187004420 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1199187004421 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1199187004422 TPP-binding site [chemical binding]; other site 1199187004423 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1199187004424 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1199187004425 GTP binding site; other site 1199187004426 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1199187004427 MULE transposase domain; Region: MULE; pfam10551 1199187004428 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1199187004429 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1199187004430 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1199187004431 NAD(P) binding pocket [chemical binding]; other site 1199187004432 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1199187004433 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187004434 active site 1199187004435 HIGH motif; other site 1199187004436 nucleotide binding site [chemical binding]; other site 1199187004437 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1199187004438 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1199187004439 active site 1199187004440 KMSKS motif; other site 1199187004441 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1199187004442 tRNA binding surface [nucleotide binding]; other site 1199187004443 anticodon binding site; other site 1199187004444 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1199187004445 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1199187004446 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1199187004447 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1199187004448 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1199187004449 active site 1199187004450 multimer interface [polypeptide binding]; other site 1199187004451 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1199187004452 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1199187004453 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1199187004454 homodimer interface [polypeptide binding]; other site 1199187004455 oligonucleotide binding site [chemical binding]; other site 1199187004456 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1199187004457 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1199187004458 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1199187004459 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1199187004460 GTP1/OBG; Region: GTP1_OBG; pfam01018 1199187004461 Obg GTPase; Region: Obg; cd01898 1199187004462 G1 box; other site 1199187004463 GTP/Mg2+ binding site [chemical binding]; other site 1199187004464 Switch I region; other site 1199187004465 G2 box; other site 1199187004466 G3 box; other site 1199187004467 Switch II region; other site 1199187004468 G4 box; other site 1199187004469 G5 box; other site 1199187004470 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1199187004471 gamma-glutamyl kinase; Provisional; Region: PRK05429 1199187004472 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1199187004473 nucleotide binding site [chemical binding]; other site 1199187004474 homotetrameric interface [polypeptide binding]; other site 1199187004475 putative phosphate binding site [ion binding]; other site 1199187004476 putative allosteric binding site; other site 1199187004477 PUA domain; Region: PUA; pfam01472 1199187004478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187004479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187004480 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187004481 Cytochrome P450; Region: p450; cl12078 1199187004482 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1199187004483 NAD-dependent deacetylase; Provisional; Region: PRK05333 1199187004484 NAD+ binding site [chemical binding]; other site 1199187004485 substrate binding site [chemical binding]; other site 1199187004486 Zn binding site [ion binding]; other site 1199187004487 Isochorismatase family; Region: Isochorismatase; pfam00857 1199187004488 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1199187004489 catalytic triad [active] 1199187004490 conserved cis-peptide bond; other site 1199187004491 NAD synthetase; Reviewed; Region: nadE; PRK02628 1199187004492 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1199187004493 multimer interface [polypeptide binding]; other site 1199187004494 active site 1199187004495 catalytic triad [active] 1199187004496 protein interface 1 [polypeptide binding]; other site 1199187004497 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1199187004498 homodimer interface [polypeptide binding]; other site 1199187004499 NAD binding pocket [chemical binding]; other site 1199187004500 ATP binding pocket [chemical binding]; other site 1199187004501 Mg binding site [ion binding]; other site 1199187004502 active-site loop [active] 1199187004503 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1199187004504 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1199187004505 substrate binding site [chemical binding]; other site 1199187004506 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1199187004507 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1199187004508 substrate binding site [chemical binding]; other site 1199187004509 ligand binding site [chemical binding]; other site 1199187004510 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1199187004511 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1199187004512 tetramer interface [polypeptide binding]; other site 1199187004513 active site 1199187004514 Mg2+/Mn2+ binding site [ion binding]; other site 1199187004515 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1199187004516 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1199187004517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187004518 DNA-binding site [nucleotide binding]; DNA binding site 1199187004519 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1199187004520 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1199187004521 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1199187004522 substrate binding site [chemical binding]; other site 1199187004523 ATP binding site [chemical binding]; other site 1199187004524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187004525 dimerization interface [polypeptide binding]; other site 1199187004526 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1199187004527 cyclase homology domain; Region: CHD; cd07302 1199187004528 nucleotidyl binding site; other site 1199187004529 metal binding site [ion binding]; metal-binding site 1199187004530 dimer interface [polypeptide binding]; other site 1199187004531 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1199187004532 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1199187004533 putative catalytic cysteine [active] 1199187004534 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1199187004535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187004536 Walker A motif; other site 1199187004537 ATP binding site [chemical binding]; other site 1199187004538 Walker B motif; other site 1199187004539 arginine finger; other site 1199187004540 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1199187004541 NifQ; Region: NifQ; pfam04891 1199187004542 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1199187004543 metal ion-dependent adhesion site (MIDAS); other site 1199187004544 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1199187004545 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1199187004546 active site 1199187004547 (T/H)XGH motif; other site 1199187004548 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1199187004549 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187004550 catalytic core [active] 1199187004551 EDD domain protein, DegV family; Region: DegV; TIGR00762 1199187004552 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1199187004553 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1199187004554 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187004555 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187004556 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1199187004557 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1199187004558 acyl-CoA synthetase; Validated; Region: PRK05850 1199187004559 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1199187004560 acyl-activating enzyme (AAE) consensus motif; other site 1199187004561 active site 1199187004562 PE-PPE domain; Region: PE-PPE; pfam08237 1199187004563 Transport protein; Region: actII; TIGR00833 1199187004564 MMPL family; Region: MMPL; pfam03176 1199187004565 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1199187004566 Condensation domain; Region: Condensation; pfam00668 1199187004567 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1199187004568 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187004569 active site 1199187004570 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1199187004571 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187004572 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1199187004573 KR domain; Region: KR; pfam08659 1199187004574 putative NADP binding site [chemical binding]; other site 1199187004575 active site 1199187004576 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187004577 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187004578 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1199187004579 active site 1199187004580 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1199187004581 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187004582 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1199187004583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187004584 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1199187004585 Enoylreductase; Region: PKS_ER; smart00829 1199187004586 NAD(P) binding site [chemical binding]; other site 1199187004587 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1199187004588 KR domain; Region: KR; pfam08659 1199187004589 putative NADP binding site [chemical binding]; other site 1199187004590 active site 1199187004591 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187004592 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1199187004593 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1199187004594 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187004595 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1199187004596 active site 1199187004597 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1199187004598 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1199187004599 FAD binding site [chemical binding]; other site 1199187004600 substrate binding site [chemical binding]; other site 1199187004601 catalytic base [active] 1199187004602 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1199187004603 Helix-hairpin-helix motif; Region: HHH; pfam00633 1199187004604 hypothetical protein; Reviewed; Region: PRK07914 1199187004605 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1199187004606 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1199187004607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1199187004608 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1199187004609 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1199187004610 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1199187004611 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1199187004612 ribonuclease Z; Reviewed; Region: PRK00055 1199187004613 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1199187004614 FOG: CBS domain [General function prediction only]; Region: COG0517 1199187004615 PemK-like protein; Region: PemK; pfam02452 1199187004616 GTP-binding protein LepA; Provisional; Region: PRK05433 1199187004617 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1199187004618 G1 box; other site 1199187004619 putative GEF interaction site [polypeptide binding]; other site 1199187004620 GTP/Mg2+ binding site [chemical binding]; other site 1199187004621 Switch I region; other site 1199187004622 G2 box; other site 1199187004623 G3 box; other site 1199187004624 Switch II region; other site 1199187004625 G4 box; other site 1199187004626 G5 box; other site 1199187004627 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1199187004628 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1199187004629 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1199187004630 PknH-like extracellular domain; Region: PknH_C; pfam14032 1199187004631 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1199187004632 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1199187004633 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1199187004634 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1199187004635 sulfate transport protein; Provisional; Region: cysT; CHL00187 1199187004636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187004637 dimer interface [polypeptide binding]; other site 1199187004638 conserved gate region; other site 1199187004639 putative PBP binding loops; other site 1199187004640 ABC-ATPase subunit interface; other site 1199187004641 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1199187004642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187004643 dimer interface [polypeptide binding]; other site 1199187004644 conserved gate region; other site 1199187004645 putative PBP binding loops; other site 1199187004646 ABC-ATPase subunit interface; other site 1199187004647 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1199187004648 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1199187004649 Walker A/P-loop; other site 1199187004650 ATP binding site [chemical binding]; other site 1199187004651 Q-loop/lid; other site 1199187004652 ABC transporter signature motif; other site 1199187004653 Walker B; other site 1199187004654 D-loop; other site 1199187004655 H-loop/switch region; other site 1199187004656 TOBE domain; Region: TOBE; pfam03459 1199187004657 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1199187004658 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1199187004659 Active Sites [active] 1199187004660 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1199187004661 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1199187004662 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1199187004663 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1199187004664 HemN C-terminal domain; Region: HemN_C; pfam06969 1199187004665 Predicted permease [General function prediction only]; Region: COG3329 1199187004666 salicylate synthase MbtI; Reviewed; Region: PRK07912 1199187004667 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1199187004668 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1199187004669 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1199187004670 homodimer interface [polypeptide binding]; other site 1199187004671 putative substrate binding pocket [chemical binding]; other site 1199187004672 diiron center [ion binding]; other site 1199187004673 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 1199187004674 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1199187004675 DNA binding residues [nucleotide binding] 1199187004676 putative dimer interface [polypeptide binding]; other site 1199187004677 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187004678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187004679 classical (c) SDRs; Region: SDR_c; cd05233 1199187004680 short chain dehydrogenase; Provisional; Region: PRK05650 1199187004681 NAD(P) binding site [chemical binding]; other site 1199187004682 active site 1199187004683 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1199187004684 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1199187004685 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004686 mce related protein; Region: MCE; pfam02470 1199187004687 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004688 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187004689 mce related protein; Region: MCE; pfam02470 1199187004690 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004691 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004692 mce related protein; Region: MCE; pfam02470 1199187004693 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004694 mce related protein; Region: MCE; pfam02470 1199187004695 Exo70 exocyst complex subunit; Region: Exo70; pfam03081 1199187004696 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004697 mce related protein; Region: MCE; pfam02470 1199187004698 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187004699 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1199187004700 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004701 acyl-activating enzyme (AAE) consensus motif; other site 1199187004702 AMP binding site [chemical binding]; other site 1199187004703 active site 1199187004704 CoA binding site [chemical binding]; other site 1199187004705 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187004706 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1199187004707 classical (c) SDRs; Region: SDR_c; cd05233 1199187004708 NAD(P) binding site [chemical binding]; other site 1199187004709 active site 1199187004710 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187004711 Cytochrome P450; Region: p450; cl12078 1199187004712 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1199187004713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187004714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187004715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004716 acyl-activating enzyme (AAE) consensus motif; other site 1199187004717 CoA binding site [chemical binding]; other site 1199187004718 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1199187004719 Condensation domain; Region: Condensation; pfam00668 1199187004720 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187004721 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1199187004722 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1199187004723 acyl-activating enzyme (AAE) consensus motif; other site 1199187004724 AMP binding site [chemical binding]; other site 1199187004725 Thioesterase domain; Region: Thioesterase; pfam00975 1199187004726 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187004727 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1199187004728 active site 1199187004729 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187004730 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1199187004731 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1199187004732 NADP binding site [chemical binding]; other site 1199187004733 active site 1199187004734 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187004735 Condensation domain; Region: Condensation; pfam00668 1199187004736 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187004737 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187004738 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187004739 acyl-activating enzyme (AAE) consensus motif; other site 1199187004740 AMP binding site [chemical binding]; other site 1199187004741 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187004742 Condensation domain; Region: Condensation; pfam00668 1199187004743 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187004744 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187004745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187004746 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187004747 AMP binding site [chemical binding]; other site 1199187004748 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187004749 Condensation domain; Region: Condensation; pfam00668 1199187004750 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187004751 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187004752 acyl-activating enzyme (AAE) consensus motif; other site 1199187004753 AMP binding site [chemical binding]; other site 1199187004754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187004755 MbtH-like protein; Region: MbtH; pfam03621 1199187004756 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1199187004757 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187004758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1199187004759 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187004760 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187004761 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1199187004762 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1199187004763 HTH domain; Region: HTH_11; cl17392 1199187004764 chaperone protein DnaJ; Provisional; Region: PRK14278 1199187004765 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1199187004766 HSP70 interaction site [polypeptide binding]; other site 1199187004767 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1199187004768 Zn binding sites [ion binding]; other site 1199187004769 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1199187004770 dimer interface [polypeptide binding]; other site 1199187004771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1199187004772 RNA methyltransferase, RsmE family; Region: TIGR00046 1199187004773 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1199187004774 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1199187004775 PhoH-like protein; Region: PhoH; pfam02562 1199187004776 metal-binding heat shock protein; Provisional; Region: PRK00016 1199187004777 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187004778 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187004779 putative transposase OrfB; Reviewed; Region: PHA02517 1199187004780 HTH-like domain; Region: HTH_21; pfam13276 1199187004781 Integrase core domain; Region: rve; pfam00665 1199187004782 Integrase core domain; Region: rve_3; cl15866 1199187004783 Transposase; Region: HTH_Tnp_1; cl17663 1199187004784 Restriction endonuclease; Region: Mrr_cat; pfam04471 1199187004785 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1199187004786 MULE transposase domain; Region: MULE; pfam10551 1199187004787 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187004788 active site 1199187004789 Int/Topo IB signature motif; other site 1199187004790 DNA binding site [nucleotide binding] 1199187004791 Domain of unknown function DUF21; Region: DUF21; pfam01595 1199187004792 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1199187004793 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1199187004794 Transporter associated domain; Region: CorC_HlyC; smart01091 1199187004795 GTPase Era; Reviewed; Region: era; PRK00089 1199187004796 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1199187004797 G1 box; other site 1199187004798 GTP/Mg2+ binding site [chemical binding]; other site 1199187004799 Switch I region; other site 1199187004800 G2 box; other site 1199187004801 Switch II region; other site 1199187004802 G3 box; other site 1199187004803 G4 box; other site 1199187004804 G5 box; other site 1199187004805 KH domain; Region: KH_2; pfam07650 1199187004806 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1199187004807 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187004808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187004809 catalytic residue [active] 1199187004810 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1199187004811 amidase; Provisional; Region: PRK06061 1199187004812 Amidase; Region: Amidase; pfam01425 1199187004813 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1199187004814 Recombination protein O N terminal; Region: RecO_N; pfam11967 1199187004815 Recombination protein O C terminal; Region: RecO_C; pfam02565 1199187004816 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1199187004817 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1199187004818 catalytic residue [active] 1199187004819 putative FPP diphosphate binding site; other site 1199187004820 putative FPP binding hydrophobic cleft; other site 1199187004821 dimer interface [polypeptide binding]; other site 1199187004822 putative IPP diphosphate binding site; other site 1199187004823 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1199187004824 metal binding site 2 [ion binding]; metal-binding site 1199187004825 putative DNA binding helix; other site 1199187004826 metal binding site 1 [ion binding]; metal-binding site 1199187004827 dimer interface [polypeptide binding]; other site 1199187004828 structural Zn2+ binding site [ion binding]; other site 1199187004829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1199187004830 dimerization interface [polypeptide binding]; other site 1199187004831 putative DNA binding site [nucleotide binding]; other site 1199187004832 putative Zn2+ binding site [ion binding]; other site 1199187004833 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1199187004834 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1199187004835 motif 1; other site 1199187004836 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1199187004837 active site 1199187004838 motif 2; other site 1199187004839 motif 3; other site 1199187004840 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1199187004841 anticodon binding site; other site 1199187004842 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187004843 PPE family; Region: PPE; pfam00823 1199187004844 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1199187004845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1199187004846 Zn2+ binding site [ion binding]; other site 1199187004847 Mg2+ binding site [ion binding]; other site 1199187004848 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1199187004849 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1199187004850 E-class dimer interface [polypeptide binding]; other site 1199187004851 P-class dimer interface [polypeptide binding]; other site 1199187004852 active site 1199187004853 Cu2+ binding site [ion binding]; other site 1199187004854 Zn2+ binding site [ion binding]; other site 1199187004855 DNA primase; Validated; Region: dnaG; PRK05667 1199187004856 CHC2 zinc finger; Region: zf-CHC2; cl17510 1199187004857 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1199187004858 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1199187004859 active site 1199187004860 metal binding site [ion binding]; metal-binding site 1199187004861 interdomain interaction site; other site 1199187004862 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1199187004863 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1199187004864 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1199187004865 Muconolactone delta-isomerase; Region: MIase; cl01992 1199187004866 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1199187004867 active site 1199187004868 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1199187004869 non-prolyl cis peptide bond; other site 1199187004870 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1199187004871 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1199187004872 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187004873 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187004874 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1199187004875 trimer interface [polypeptide binding]; other site 1199187004876 active site 1199187004877 substrate binding site [chemical binding]; other site 1199187004878 CoA binding site [chemical binding]; other site 1199187004879 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1199187004880 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1199187004881 dimer interface [polypeptide binding]; other site 1199187004882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187004883 catalytic residue [active] 1199187004884 TQXA domain; Region: TQXA_dom; TIGR03934 1199187004885 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1199187004886 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1199187004887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187004888 catalytic residue [active] 1199187004889 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1199187004890 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 1199187004891 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187004892 Permease; Region: Permease; pfam02405 1199187004893 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004894 mce related protein; Region: MCE; pfam02470 1199187004895 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187004896 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004897 mce related protein; Region: MCE; pfam02470 1199187004898 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004899 mce related protein; Region: MCE; pfam02470 1199187004900 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1199187004901 dimer interface [polypeptide binding]; other site 1199187004902 mce related protein; Region: MCE; pfam02470 1199187004903 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004904 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004905 mce related protein; Region: MCE; pfam02470 1199187004906 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187004907 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187004908 mce related protein; Region: MCE; pfam02470 1199187004909 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187004910 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187004911 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1199187004912 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1199187004913 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1199187004914 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1199187004915 [4Fe-4S] binding site [ion binding]; other site 1199187004916 molybdopterin cofactor binding site; other site 1199187004917 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1199187004918 molybdopterin cofactor binding site; other site 1199187004919 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1199187004920 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1199187004921 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1199187004922 FAD binding pocket [chemical binding]; other site 1199187004923 FAD binding motif [chemical binding]; other site 1199187004924 catalytic residues [active] 1199187004925 NAD binding pocket [chemical binding]; other site 1199187004926 phosphate binding motif [ion binding]; other site 1199187004927 beta-alpha-beta structure motif; other site 1199187004928 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1199187004929 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1199187004930 acyl-coenzyme A oxidase; Region: PLN02636 1199187004931 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187004932 active site 1199187004933 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1199187004934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187004935 Walker A/P-loop; other site 1199187004936 ATP binding site [chemical binding]; other site 1199187004937 Q-loop/lid; other site 1199187004938 ABC transporter signature motif; other site 1199187004939 Walker B; other site 1199187004940 D-loop; other site 1199187004941 H-loop/switch region; other site 1199187004942 MarR family; Region: MarR; pfam01047 1199187004943 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1199187004944 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 1199187004945 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1199187004946 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1199187004947 Walker A/P-loop; other site 1199187004948 ATP binding site [chemical binding]; other site 1199187004949 Q-loop/lid; other site 1199187004950 ABC transporter signature motif; other site 1199187004951 Walker B; other site 1199187004952 D-loop; other site 1199187004953 H-loop/switch region; other site 1199187004954 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1199187004955 Walker A/P-loop; other site 1199187004956 ATP binding site [chemical binding]; other site 1199187004957 Q-loop/lid; other site 1199187004958 ABC transporter signature motif; other site 1199187004959 Walker B; other site 1199187004960 D-loop; other site 1199187004961 H-loop/switch region; other site 1199187004962 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1199187004963 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1199187004964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1199187004965 putative DNA binding site [nucleotide binding]; other site 1199187004966 putative Zn2+ binding site [ion binding]; other site 1199187004967 AsnC family; Region: AsnC_trans_reg; pfam01037 1199187004968 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1199187004969 Amidinotransferase; Region: Amidinotransf; pfam02274 1199187004970 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1199187004971 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1199187004972 inhibitor-cofactor binding pocket; inhibition site 1199187004973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187004974 catalytic residue [active] 1199187004975 amino acid transporter; Region: 2A0306; TIGR00909 1199187004976 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1199187004977 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1199187004978 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1199187004979 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1199187004980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1199187004981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187004982 dimer interface [polypeptide binding]; other site 1199187004983 conserved gate region; other site 1199187004984 putative PBP binding loops; other site 1199187004985 ABC-ATPase subunit interface; other site 1199187004986 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1199187004987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1199187004988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187004989 dimer interface [polypeptide binding]; other site 1199187004990 putative PBP binding loops; other site 1199187004991 ABC-ATPase subunit interface; other site 1199187004992 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1199187004993 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1199187004994 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187004995 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1199187004996 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1199187004997 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1199187004998 NAD(P) binding site [chemical binding]; other site 1199187004999 catalytic residues [active] 1199187005000 Repair protein; Region: Repair_PSII; pfam04536 1199187005001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1199187005002 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1199187005003 AAA domain; Region: AAA_33; pfam13671 1199187005004 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1199187005005 active site 1199187005006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187005007 putative substrate translocation pore; other site 1199187005008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187005009 putative substrate translocation pore; other site 1199187005010 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1199187005011 catalytic triad [active] 1199187005012 active site nucleophile [active] 1199187005013 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1199187005014 DNA binding site [nucleotide binding] 1199187005015 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1199187005016 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1199187005017 cyclase homology domain; Region: CHD; cd07302 1199187005018 nucleotidyl binding site; other site 1199187005019 metal binding site [ion binding]; metal-binding site 1199187005020 dimer interface [polypeptide binding]; other site 1199187005021 Predicted ATPase [General function prediction only]; Region: COG3899 1199187005022 AAA ATPase domain; Region: AAA_16; pfam13191 1199187005023 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1199187005024 GAF domain; Region: GAF_3; pfam13492 1199187005025 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1199187005026 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1199187005027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187005028 ATP binding site [chemical binding]; other site 1199187005029 Mg2+ binding site [ion binding]; other site 1199187005030 G-X-G motif; other site 1199187005031 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187005032 regulatory phosphorylation site [posttranslational modification]; other site 1199187005033 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187005034 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187005035 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1199187005036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187005037 S-adenosylmethionine binding site [chemical binding]; other site 1199187005038 CCC1-related family of proteins; Region: CCC1_like; cl00278 1199187005039 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1199187005040 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1199187005041 active site 2 [active] 1199187005042 active site 1 [active] 1199187005043 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1199187005044 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1199187005045 acyl-activating enzyme (AAE) consensus motif; other site 1199187005046 putative AMP binding site [chemical binding]; other site 1199187005047 putative active site [active] 1199187005048 putative CoA binding site [chemical binding]; other site 1199187005049 TIGR03085 family protein; Region: TIGR03085 1199187005050 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1199187005051 heat shock protein 90; Provisional; Region: PRK05218 1199187005052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187005053 ATP binding site [chemical binding]; other site 1199187005054 Mg2+ binding site [ion binding]; other site 1199187005055 G-X-G motif; other site 1199187005056 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187005057 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187005058 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1199187005059 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1199187005060 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1199187005061 MgtE intracellular N domain; Region: MgtE_N; smart00924 1199187005062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1199187005063 PknH-like extracellular domain; Region: PknH_C; pfam14032 1199187005064 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1199187005065 dimer interface [polypeptide binding]; other site 1199187005066 ligand binding site [chemical binding]; other site 1199187005067 Predicted membrane protein [Function unknown]; Region: COG4270 1199187005068 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187005069 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1199187005070 dimer interface [polypeptide binding]; other site 1199187005071 active site 1199187005072 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1199187005073 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1199187005074 active site 1199187005075 haloalkane dehalogenase; Provisional; Region: PRK00870 1199187005076 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1199187005077 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1199187005078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187005079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187005080 homodimer interface [polypeptide binding]; other site 1199187005081 catalytic residue [active] 1199187005082 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187005083 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1199187005084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005086 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187005087 Cytochrome P450; Region: p450; cl12078 1199187005088 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187005089 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187005090 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187005091 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187005092 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1199187005093 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1199187005094 active site residue [active] 1199187005095 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1199187005096 active site residue [active] 1199187005097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187005098 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1199187005099 Predicted ATPase [General function prediction only]; Region: COG4637 1199187005100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187005101 Walker A/P-loop; other site 1199187005102 ATP binding site [chemical binding]; other site 1199187005103 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1199187005104 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1199187005105 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187005106 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187005107 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187005108 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1199187005109 HicB family; Region: HicB; pfam05534 1199187005110 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1199187005111 4Fe-4S binding domain; Region: Fer4; cl02805 1199187005112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1199187005113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1199187005114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1199187005115 dimerization interface [polypeptide binding]; other site 1199187005116 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1199187005117 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1199187005118 Active Sites [active] 1199187005119 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1199187005120 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1199187005121 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1199187005122 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187005123 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187005124 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187005125 Cytochrome P450; Region: p450; cl12078 1199187005126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005128 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1199187005129 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1199187005130 active site 1199187005131 ATP binding site [chemical binding]; other site 1199187005132 substrate binding site [chemical binding]; other site 1199187005133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1199187005134 activation loop (A-loop); other site 1199187005135 activation loop (A-loop); other site 1199187005136 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187005137 Cytochrome P450; Region: p450; cl12078 1199187005138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187005139 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1199187005140 active site 1199187005141 metal binding site [ion binding]; metal-binding site 1199187005142 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1199187005143 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1199187005144 oligomeric interface; other site 1199187005145 putative active site [active] 1199187005146 homodimer interface [polypeptide binding]; other site 1199187005147 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1199187005148 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1199187005149 active site 1199187005150 ATP binding site [chemical binding]; other site 1199187005151 substrate binding site [chemical binding]; other site 1199187005152 activation loop (A-loop); other site 1199187005153 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187005154 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187005155 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187005156 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187005157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005159 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187005160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187005161 active site 1199187005162 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1199187005163 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1199187005164 active site 1199187005165 metal binding site [ion binding]; metal-binding site 1199187005166 Cutinase; Region: Cutinase; pfam01083 1199187005167 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187005168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187005169 Septum formation; Region: Septum_form; pfam13845 1199187005170 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1199187005171 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187005172 Cytochrome P450; Region: p450; cl12078 1199187005173 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187005174 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187005175 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1199187005176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1199187005177 nucleotide binding site [chemical binding]; other site 1199187005178 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 1199187005179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187005180 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1199187005181 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1199187005182 NAD binding site [chemical binding]; other site 1199187005183 catalytic Zn binding site [ion binding]; other site 1199187005184 substrate binding site [chemical binding]; other site 1199187005185 structural Zn binding site [ion binding]; other site 1199187005186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187005187 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1199187005188 S-adenosylmethionine binding site [chemical binding]; other site 1199187005189 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1199187005190 Beta-lactamase; Region: Beta-lactamase; pfam00144 1199187005191 diacylglycerol kinase; Reviewed; Region: PRK11914 1199187005192 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1199187005193 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1199187005194 FAD binding domain; Region: FAD_binding_4; pfam01565 1199187005195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005197 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1199187005198 FAD binding domain; Region: FAD_binding_3; pfam01494 1199187005199 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1199187005200 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1199187005201 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1199187005202 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1199187005203 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1199187005204 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1199187005205 dimer interface [polypeptide binding]; other site 1199187005206 active site 1199187005207 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1199187005208 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1199187005209 dimer interface [polypeptide binding]; other site 1199187005210 active site 1199187005211 acyl carrier protein; Provisional; Region: acpP; PRK00982 1199187005212 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1199187005213 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1199187005214 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1199187005215 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1199187005216 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1199187005217 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1199187005218 dimer interface [polypeptide binding]; other site 1199187005219 TPP-binding site [chemical binding]; other site 1199187005220 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1199187005221 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1199187005222 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1199187005223 dimer interface [polypeptide binding]; other site 1199187005224 catalytic triad [active] 1199187005225 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1199187005226 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1199187005227 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187005228 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1199187005229 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1199187005230 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1199187005231 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1199187005232 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1199187005233 active site 1199187005234 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1199187005235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187005236 motif II; other site 1199187005237 hypothetical protein; Provisional; Region: PRK07908 1199187005238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187005239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187005240 homodimer interface [polypeptide binding]; other site 1199187005241 catalytic residue [active] 1199187005242 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1199187005243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1199187005244 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1199187005245 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1199187005246 5' nucleotidase family; Region: 5_nucleotid; cl17687 1199187005247 Putative zinc ribbon domain; Region: DUF164; pfam02591 1199187005248 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1199187005249 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1199187005250 RNA/DNA hybrid binding site [nucleotide binding]; other site 1199187005251 active site 1199187005252 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187005253 catalytic core [active] 1199187005254 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1199187005255 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187005256 Cytochrome P450; Region: p450; cl12078 1199187005257 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1199187005258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187005259 sequence-specific DNA binding site [nucleotide binding]; other site 1199187005260 salt bridge; other site 1199187005261 Cupin domain; Region: Cupin_2; pfam07883 1199187005262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187005263 S-adenosylmethionine binding site [chemical binding]; other site 1199187005264 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1199187005265 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1199187005266 putative active site; other site 1199187005267 putative metal binding residues [ion binding]; other site 1199187005268 signature motif; other site 1199187005269 putative triphosphate binding site [ion binding]; other site 1199187005270 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1199187005271 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1199187005272 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1199187005273 oligomerization interface [polypeptide binding]; other site 1199187005274 active site 1199187005275 metal binding site [ion binding]; metal-binding site 1199187005276 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1199187005277 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187005278 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1199187005279 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1199187005280 TAP-like protein; Region: Abhydrolase_4; pfam08386 1199187005281 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1199187005282 TAP-like protein; Region: Abhydrolase_4; pfam08386 1199187005283 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1199187005284 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1199187005285 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1199187005286 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1199187005287 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1199187005288 metal binding triad; other site 1199187005289 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1199187005290 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1199187005291 metal binding triad; other site 1199187005292 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1199187005293 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187005294 CoenzymeA binding site [chemical binding]; other site 1199187005295 subunit interaction site [polypeptide binding]; other site 1199187005296 PHB binding site; other site 1199187005297 glutamine synthetase, type I; Region: GlnA; TIGR00653 1199187005298 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1199187005299 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1199187005300 RDD family; Region: RDD; pfam06271 1199187005301 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1199187005302 lipoyl synthase; Provisional; Region: PRK05481 1199187005303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1199187005304 FeS/SAM binding site; other site 1199187005305 lipoate-protein ligase B; Provisional; Region: PRK14345 1199187005306 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1199187005307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187005308 NAD(P) binding site [chemical binding]; other site 1199187005309 active site 1199187005310 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1199187005311 E3 interaction surface; other site 1199187005312 lipoyl attachment site [posttranslational modification]; other site 1199187005313 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1199187005314 E3 interaction surface; other site 1199187005315 lipoyl attachment site [posttranslational modification]; other site 1199187005316 e3 binding domain; Region: E3_binding; pfam02817 1199187005317 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1199187005318 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1199187005319 short chain dehydrogenase; Validated; Region: PRK05855 1199187005320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187005321 classical (c) SDRs; Region: SDR_c; cd05233 1199187005322 NAD(P) binding site [chemical binding]; other site 1199187005323 active site 1199187005324 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1199187005325 hydrophobic ligand binding site; other site 1199187005326 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1199187005327 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1199187005328 interface (dimer of trimers) [polypeptide binding]; other site 1199187005329 Substrate-binding/catalytic site; other site 1199187005330 Zn-binding sites [ion binding]; other site 1199187005331 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187005332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1199187005333 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187005334 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1199187005335 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1199187005336 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1199187005337 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1199187005338 homodimer interface [polypeptide binding]; other site 1199187005339 substrate-cofactor binding pocket; other site 1199187005340 catalytic residue [active] 1199187005341 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1199187005342 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1199187005343 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1199187005344 putative dimer interface [polypeptide binding]; other site 1199187005345 active site pocket [active] 1199187005346 putative cataytic base [active] 1199187005347 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1199187005348 homotrimer interface [polypeptide binding]; other site 1199187005349 Walker A motif; other site 1199187005350 GTP binding site [chemical binding]; other site 1199187005351 Walker B motif; other site 1199187005352 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1199187005353 Glycerate kinase family; Region: Gly_kinase; pfam02595 1199187005354 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1199187005355 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1199187005356 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1199187005357 substrate binding site [chemical binding]; other site 1199187005358 ATP binding site [chemical binding]; other site 1199187005359 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1199187005360 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1199187005361 dimer interface [polypeptide binding]; other site 1199187005362 active site 1199187005363 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1199187005364 Ligand Binding Site [chemical binding]; other site 1199187005365 Molecular Tunnel; other site 1199187005366 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1199187005367 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1199187005368 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1199187005369 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187005370 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1199187005371 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1199187005372 heme bH binding site [chemical binding]; other site 1199187005373 intrachain domain interface; other site 1199187005374 heme bL binding site [chemical binding]; other site 1199187005375 interchain domain interface [polypeptide binding]; other site 1199187005376 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1199187005377 Qo binding site; other site 1199187005378 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1199187005379 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1199187005380 iron-sulfur cluster [ion binding]; other site 1199187005381 [2Fe-2S] cluster binding site [ion binding]; other site 1199187005382 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1199187005383 Cytochrome c; Region: Cytochrom_C; pfam00034 1199187005384 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1199187005385 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1199187005386 Subunit I/III interface [polypeptide binding]; other site 1199187005387 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1199187005388 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1199187005389 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1199187005390 hypothetical protein; Validated; Region: PRK07883 1199187005391 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1199187005392 active site 1199187005393 substrate binding site [chemical binding]; other site 1199187005394 catalytic site [active] 1199187005395 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1199187005396 GIY-YIG motif/motif A; other site 1199187005397 active site 1199187005398 catalytic site [active] 1199187005399 putative DNA binding site [nucleotide binding]; other site 1199187005400 metal binding site [ion binding]; metal-binding site 1199187005401 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1199187005402 NlpC/P60 family; Region: NLPC_P60; pfam00877 1199187005403 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1199187005404 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1199187005405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187005406 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1199187005407 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1199187005408 acyl-activating enzyme (AAE) consensus motif; other site 1199187005409 putative AMP binding site [chemical binding]; other site 1199187005410 putative active site [active] 1199187005411 putative CoA binding site [chemical binding]; other site 1199187005412 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1199187005413 putative hydrophobic ligand binding site [chemical binding]; other site 1199187005414 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1199187005415 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1199187005416 DTAP/Switch II; other site 1199187005417 Switch I; other site 1199187005418 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187005419 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1199187005420 putative acyl-acceptor binding pocket; other site 1199187005421 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1199187005422 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1199187005423 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1199187005424 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1199187005425 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1199187005426 active site 1199187005427 ATP binding site [chemical binding]; other site 1199187005428 substrate binding site [chemical binding]; other site 1199187005429 activation loop (A-loop); other site 1199187005430 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1199187005431 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1199187005432 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1199187005433 substrate binding pocket [chemical binding]; other site 1199187005434 chain length determination region; other site 1199187005435 substrate-Mg2+ binding site; other site 1199187005436 catalytic residues [active] 1199187005437 aspartate-rich region 1; other site 1199187005438 active site lid residues [active] 1199187005439 aspartate-rich region 2; other site 1199187005440 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1199187005441 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1199187005442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1199187005443 MraZ protein; Region: MraZ; pfam02381 1199187005444 MraZ protein; Region: MraZ; pfam02381 1199187005445 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1199187005446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187005447 S-adenosylmethionine binding site [chemical binding]; other site 1199187005448 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1199187005449 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1199187005450 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1199187005451 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1199187005452 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1199187005453 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1199187005454 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1199187005455 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1199187005456 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1199187005457 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1199187005458 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1199187005459 Mg++ binding site [ion binding]; other site 1199187005460 putative catalytic motif [active] 1199187005461 putative substrate binding site [chemical binding]; other site 1199187005462 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1199187005463 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1199187005464 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1199187005465 cell division protein FtsW; Region: ftsW; TIGR02614 1199187005466 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1199187005467 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1199187005468 active site 1199187005469 homodimer interface [polypeptide binding]; other site 1199187005470 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1199187005471 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1199187005472 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1199187005473 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1199187005474 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1199187005475 Cell division protein FtsQ; Region: FtsQ; pfam03799 1199187005476 cell division protein FtsZ; Validated; Region: PRK09330 1199187005477 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1199187005478 nucleotide binding site [chemical binding]; other site 1199187005479 SulA interaction site; other site 1199187005480 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1199187005481 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1199187005482 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1199187005483 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1199187005484 catalytic residue [active] 1199187005485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1199187005486 Predicted integral membrane protein [Function unknown]; Region: COG0762 1199187005487 DivIVA domain; Region: DivI1A_domain; TIGR03544 1199187005488 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1199187005489 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1199187005490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1199187005491 active site 1199187005492 hypothetical protein; Provisional; Region: PRK07906 1199187005493 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1199187005494 putative metal binding site [ion binding]; other site 1199187005495 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1199187005496 substrate binding site [chemical binding]; other site 1199187005497 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187005498 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187005499 active site 1199187005500 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1199187005501 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1199187005502 quinone interaction residues [chemical binding]; other site 1199187005503 active site 1199187005504 catalytic residues [active] 1199187005505 FMN binding site [chemical binding]; other site 1199187005506 substrate binding site [chemical binding]; other site 1199187005507 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187005508 catalytic core [active] 1199187005509 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1199187005510 conserved hypothetical protein; Region: TIGR03843 1199187005511 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1199187005512 active site 1199187005513 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187005514 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1199187005515 active site 1199187005516 HIGH motif; other site 1199187005517 nucleotide binding site [chemical binding]; other site 1199187005518 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187005519 active site 1199187005520 KMSKS motif; other site 1199187005521 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1199187005522 putative tRNA binding surface [nucleotide binding]; other site 1199187005523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187005524 Walker A motif; other site 1199187005525 ATP binding site [chemical binding]; other site 1199187005526 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1199187005527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1199187005528 DNA binding residues [nucleotide binding] 1199187005529 dimerization interface [polypeptide binding]; other site 1199187005530 AAA ATPase domain; Region: AAA_16; pfam13191 1199187005531 AAA domain; Region: AAA_22; pfam13401 1199187005532 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1199187005533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1199187005534 DNA binding residues [nucleotide binding] 1199187005535 dimerization interface [polypeptide binding]; other site 1199187005536 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1199187005537 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1199187005538 PYR/PP interface [polypeptide binding]; other site 1199187005539 dimer interface [polypeptide binding]; other site 1199187005540 TPP binding site [chemical binding]; other site 1199187005541 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1199187005542 TPP-binding site [chemical binding]; other site 1199187005543 MbtH-like protein; Region: MbtH; pfam03621 1199187005544 Condensation domain; Region: Condensation; pfam00668 1199187005545 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187005546 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1199187005547 acyl-activating enzyme (AAE) consensus motif; other site 1199187005548 AMP binding site [chemical binding]; other site 1199187005549 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187005550 Condensation domain; Region: Condensation; pfam00668 1199187005551 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187005552 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187005553 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187005554 acyl-activating enzyme (AAE) consensus motif; other site 1199187005555 AMP binding site [chemical binding]; other site 1199187005556 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187005557 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1199187005558 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1199187005559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187005560 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187005561 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 1199187005562 active site 1199187005563 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1199187005564 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1199187005565 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1199187005566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187005567 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1199187005568 Enoylreductase; Region: PKS_ER; smart00829 1199187005569 NAD(P) binding site [chemical binding]; other site 1199187005570 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1199187005571 KR domain; Region: KR; pfam08659 1199187005572 putative NADP binding site [chemical binding]; other site 1199187005573 active site 1199187005574 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187005575 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187005576 Cytochrome P450; Region: p450; cl12078 1199187005577 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1199187005578 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1199187005579 FAD binding pocket [chemical binding]; other site 1199187005580 FAD binding motif [chemical binding]; other site 1199187005581 phosphate binding motif [ion binding]; other site 1199187005582 NAD binding pocket [chemical binding]; other site 1199187005583 short chain dehydrogenase; Provisional; Region: PRK05872 1199187005584 classical (c) SDRs; Region: SDR_c; cd05233 1199187005585 NAD(P) binding site [chemical binding]; other site 1199187005586 active site 1199187005587 PAC2 family; Region: PAC2; pfam09754 1199187005588 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1199187005589 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1199187005590 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1199187005591 substrate binding pocket [chemical binding]; other site 1199187005592 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1199187005593 B12 binding site [chemical binding]; other site 1199187005594 cobalt ligand [ion binding]; other site 1199187005595 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1199187005596 Mannan-binding protein; Region: MVL; pfam12151 1199187005597 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187005598 mce related protein; Region: MCE; pfam02470 1199187005599 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187005600 mce related protein; Region: MCE; pfam02470 1199187005601 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187005602 mce related protein; Region: MCE; pfam02470 1199187005603 mce related protein; Region: MCE; pfam02470 1199187005604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187005605 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187005606 mce related protein; Region: MCE; pfam02470 1199187005607 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1199187005608 mce related protein; Region: MCE; pfam02470 1199187005609 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187005610 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187005611 Permease; Region: Permease; pfam02405 1199187005612 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187005613 Permease; Region: Permease; pfam02405 1199187005614 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1199187005615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005616 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1199187005617 homodimer interface [polypeptide binding]; other site 1199187005618 putative metal binding site [ion binding]; other site 1199187005619 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1199187005620 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1199187005621 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1199187005622 Predicted membrane protein [Function unknown]; Region: COG3918 1199187005623 mercuric reductase; Validated; Region: PRK06370 1199187005624 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1199187005625 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187005626 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1199187005627 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1199187005628 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1199187005629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187005630 S-adenosylmethionine binding site [chemical binding]; other site 1199187005631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1199187005632 proteasome ATPase; Region: pup_AAA; TIGR03689 1199187005633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187005634 Walker A motif; other site 1199187005635 ATP binding site [chemical binding]; other site 1199187005636 Walker B motif; other site 1199187005637 arginine finger; other site 1199187005638 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1199187005639 Pup-like protein; Region: Pup; pfam05639 1199187005640 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1199187005641 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1199187005642 active site 1199187005643 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1199187005644 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1199187005645 active site 1199187005646 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1199187005647 Predicted transcriptional regulator [Transcription]; Region: COG2378 1199187005648 WYL domain; Region: WYL; pfam13280 1199187005649 Predicted transcriptional regulator [Transcription]; Region: COG2378 1199187005650 WYL domain; Region: WYL; pfam13280 1199187005651 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1199187005652 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1199187005653 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1199187005654 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1199187005655 5'-3' exonuclease; Region: 53EXOc; smart00475 1199187005656 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1199187005657 active site 1199187005658 metal binding site 1 [ion binding]; metal-binding site 1199187005659 putative 5' ssDNA interaction site; other site 1199187005660 metal binding site 3; metal-binding site 1199187005661 metal binding site 2 [ion binding]; metal-binding site 1199187005662 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1199187005663 putative DNA binding site [nucleotide binding]; other site 1199187005664 putative metal binding site [ion binding]; other site 1199187005665 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1199187005666 Helix-turn-helix domain; Region: HTH_38; pfam13936 1199187005667 DNA-binding interface [nucleotide binding]; DNA binding site 1199187005668 Integrase core domain; Region: rve; pfam00665 1199187005669 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1199187005670 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1199187005671 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1199187005672 active site 1199187005673 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1199187005674 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1199187005675 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1199187005676 active site 1199187005677 putative homodimer interface [polypeptide binding]; other site 1199187005678 SAM binding site [chemical binding]; other site 1199187005679 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1199187005680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1199187005681 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1199187005682 active site 1199187005683 SAM binding site [chemical binding]; other site 1199187005684 homodimer interface [polypeptide binding]; other site 1199187005685 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1199187005686 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1199187005687 Putative zinc-finger; Region: zf-HC2; pfam13490 1199187005688 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 1199187005689 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1199187005690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187005691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187005692 DNA binding residues [nucleotide binding] 1199187005693 PPE family; Region: PPE; pfam00823 1199187005694 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187005695 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1199187005696 active site 1199187005697 SAM binding site [chemical binding]; other site 1199187005698 homodimer interface [polypeptide binding]; other site 1199187005699 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1199187005700 active site 1199187005701 SAM binding site [chemical binding]; other site 1199187005702 homodimer interface [polypeptide binding]; other site 1199187005703 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1199187005704 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1199187005705 precorrin-3B synthase; Region: CobG; TIGR02435 1199187005706 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1199187005707 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1199187005708 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1199187005709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187005710 dimer interface [polypeptide binding]; other site 1199187005711 conserved gate region; other site 1199187005712 putative PBP binding loops; other site 1199187005713 ABC-ATPase subunit interface; other site 1199187005714 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1199187005715 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1199187005716 Walker A/P-loop; other site 1199187005717 ATP binding site [chemical binding]; other site 1199187005718 Q-loop/lid; other site 1199187005719 ABC transporter signature motif; other site 1199187005720 Walker B; other site 1199187005721 D-loop; other site 1199187005722 H-loop/switch region; other site 1199187005723 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1199187005724 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1199187005725 substrate binding pocket [chemical binding]; other site 1199187005726 membrane-bound complex binding site; other site 1199187005727 hinge residues; other site 1199187005728 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1199187005729 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187005730 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1199187005731 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1199187005732 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1199187005733 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1199187005734 Dienelactone hydrolase family; Region: DLH; pfam01738 1199187005735 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1199187005736 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1199187005737 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1199187005738 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187005739 active site 1199187005740 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1199187005741 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1199187005742 putative active site [active] 1199187005743 catalytic triad [active] 1199187005744 putative dimer interface [polypeptide binding]; other site 1199187005745 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1199187005746 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1199187005747 Ligand binding site; other site 1199187005748 Putative Catalytic site; other site 1199187005749 DXD motif; other site 1199187005750 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1199187005751 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1199187005752 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187005753 active site 1199187005754 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187005755 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1199187005756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187005757 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1199187005758 Enoylreductase; Region: PKS_ER; smart00829 1199187005759 NAD(P) binding site [chemical binding]; other site 1199187005760 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1199187005761 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1199187005762 putative NADP binding site [chemical binding]; other site 1199187005763 active site 1199187005764 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187005765 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1199187005766 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187005767 active site 1199187005768 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187005769 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1199187005770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187005771 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1199187005772 Enoylreductase; Region: PKS_ER; smart00829 1199187005773 NAD(P) binding site [chemical binding]; other site 1199187005774 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1199187005775 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1199187005776 putative NADP binding site [chemical binding]; other site 1199187005777 active site 1199187005778 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187005779 hypothetical protein; Provisional; Region: PRK05865 1199187005780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187005781 NAD(P) binding site [chemical binding]; other site 1199187005782 active site 1199187005783 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1199187005784 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187005785 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187005786 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1199187005787 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1199187005788 Walker A motif; other site 1199187005789 ATP binding site [chemical binding]; other site 1199187005790 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1199187005791 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1199187005792 metal ion-dependent adhesion site (MIDAS); other site 1199187005793 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187005794 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1199187005795 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187005796 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187005797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005798 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187005799 Cytochrome P450; Region: p450; cl12078 1199187005800 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1199187005801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187005802 substrate binding pocket [chemical binding]; other site 1199187005803 catalytic triad [active] 1199187005804 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187005805 Ecdysteroid kinase; Region: EcKinase; cl17738 1199187005806 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1199187005807 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1199187005808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1199187005809 AAA domain; Region: AAA_33; pfam13671 1199187005810 Predicted membrane protein [Function unknown]; Region: COG2259 1199187005811 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1199187005812 Isochorismatase family; Region: Isochorismatase; pfam00857 1199187005813 catalytic triad [active] 1199187005814 conserved cis-peptide bond; other site 1199187005815 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1199187005816 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187005817 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187005818 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1199187005819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187005820 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1199187005821 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1199187005822 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1199187005823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187005824 dimer interface [polypeptide binding]; other site 1199187005825 conserved gate region; other site 1199187005826 putative PBP binding loops; other site 1199187005827 ABC-ATPase subunit interface; other site 1199187005828 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1199187005829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187005830 dimer interface [polypeptide binding]; other site 1199187005831 conserved gate region; other site 1199187005832 putative PBP binding loops; other site 1199187005833 ABC-ATPase subunit interface; other site 1199187005834 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1199187005835 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1199187005836 Walker A/P-loop; other site 1199187005837 ATP binding site [chemical binding]; other site 1199187005838 Q-loop/lid; other site 1199187005839 ABC transporter signature motif; other site 1199187005840 Walker B; other site 1199187005841 D-loop; other site 1199187005842 H-loop/switch region; other site 1199187005843 TOBE domain; Region: TOBE_2; pfam08402 1199187005844 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1199187005845 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1199187005846 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1199187005847 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1199187005848 Iron permease FTR1 family; Region: FTR1; cl00475 1199187005849 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1199187005850 Imelysin; Region: Peptidase_M75; pfam09375 1199187005851 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1199187005852 OsmC-like protein; Region: OsmC; pfam02566 1199187005853 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187005854 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187005855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187005856 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 1199187005857 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1199187005858 Universal stress protein family; Region: Usp; pfam00582 1199187005859 Ligand Binding Site [chemical binding]; other site 1199187005860 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1199187005861 Ligand Binding Site [chemical binding]; other site 1199187005862 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1199187005863 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187005864 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187005865 active site 1199187005866 catalytic tetrad [active] 1199187005867 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1199187005868 extended (e) SDRs; Region: SDR_e; cd08946 1199187005869 NAD(P) binding site [chemical binding]; other site 1199187005870 active site 1199187005871 substrate binding site [chemical binding]; other site 1199187005872 SnoaL-like domain; Region: SnoaL_4; pfam13577 1199187005873 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1199187005874 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187005875 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187005876 active site 1199187005877 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1199187005878 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1199187005879 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 1199187005880 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1199187005881 dimer interface [polypeptide binding]; other site 1199187005882 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1199187005883 Ligand Binding Site [chemical binding]; other site 1199187005884 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1199187005885 Ligand Binding Site [chemical binding]; other site 1199187005886 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1199187005887 Ligand Binding Site [chemical binding]; other site 1199187005888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1199187005889 PAS domain; Region: PAS_9; pfam13426 1199187005890 putative active site [active] 1199187005891 heme pocket [chemical binding]; other site 1199187005892 PAS domain S-box; Region: sensory_box; TIGR00229 1199187005893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1199187005894 putative active site [active] 1199187005895 heme pocket [chemical binding]; other site 1199187005896 Histidine kinase; Region: HisKA_3; pfam07730 1199187005897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187005898 Mg2+ binding site [ion binding]; other site 1199187005899 G-X-G motif; other site 1199187005900 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1199187005901 homotetramer interface [polypeptide binding]; other site 1199187005902 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187005903 NAD binding site [chemical binding]; other site 1199187005904 homodimer interface [polypeptide binding]; other site 1199187005905 active site 1199187005906 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1199187005907 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187005908 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1199187005909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005910 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187005911 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187005912 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187005913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005915 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1199187005916 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1199187005917 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1199187005918 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1199187005919 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1199187005920 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1199187005921 active site 1199187005922 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1199187005923 catalytic triad [active] 1199187005924 dimer interface [polypeptide binding]; other site 1199187005925 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1199187005926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187005927 motif II; other site 1199187005928 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1199187005929 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187005930 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187005931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005933 WHG domain; Region: WHG; pfam13305 1199187005934 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1199187005935 putative heme binding pocket [chemical binding]; other site 1199187005936 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1199187005937 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1199187005938 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1199187005939 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187005940 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187005941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005943 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1199187005944 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1199187005945 putative NAD(P) binding site [chemical binding]; other site 1199187005946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005948 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1199187005949 LGFP repeat; Region: LGFP; pfam08310 1199187005950 short chain dehydrogenase; Provisional; Region: PRK07825 1199187005951 classical (c) SDRs; Region: SDR_c; cd05233 1199187005952 NAD(P) binding site [chemical binding]; other site 1199187005953 active site 1199187005954 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1199187005955 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187005956 substrate binding site [chemical binding]; other site 1199187005957 oxyanion hole (OAH) forming residues; other site 1199187005958 trimer interface [polypeptide binding]; other site 1199187005959 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1199187005960 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1199187005961 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1199187005962 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187005963 dimer interface [polypeptide binding]; other site 1199187005964 active site 1199187005965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187005966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187005967 active site 1199187005968 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187005969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187005970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187005971 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1199187005972 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1199187005973 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187005974 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1199187005975 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1199187005976 acyl-activating enzyme (AAE) consensus motif; other site 1199187005977 putative AMP binding site [chemical binding]; other site 1199187005978 putative active site [active] 1199187005979 putative CoA binding site [chemical binding]; other site 1199187005980 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1199187005981 short chain dehydrogenase; Provisional; Region: PRK07577 1199187005982 classical (c) SDRs; Region: SDR_c; cd05233 1199187005983 NAD(P) binding site [chemical binding]; other site 1199187005984 active site 1199187005985 Cellulose binding domain; Region: CBM_2; pfam00553 1199187005986 Helix-turn-helix domain; Region: HTH_18; pfam12833 1199187005987 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1199187005988 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187005989 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187005990 polycystin cation channel protein; Region: PCC; TIGR00864 1199187005991 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 1199187005992 biotin carboxylase-like protein; Validated; Region: PRK06524 1199187005993 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1199187005994 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1199187005995 Beta-lactamase; Region: Beta-lactamase; pfam00144 1199187005996 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1199187005997 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1199187005998 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1199187005999 Ligand Binding Site [chemical binding]; other site 1199187006000 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1199187006001 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1199187006002 putative dimer interface [polypeptide binding]; other site 1199187006003 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1199187006004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1199187006005 DNA binding residues [nucleotide binding] 1199187006006 putative dimer interface [polypeptide binding]; other site 1199187006007 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1199187006008 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1199187006009 putative dimer interface [polypeptide binding]; other site 1199187006010 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1199187006011 HSP70 interaction site [polypeptide binding]; other site 1199187006012 Condensation domain; Region: Condensation; pfam00668 1199187006013 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1199187006014 short chain dehydrogenase; Provisional; Region: PRK06500 1199187006015 classical (c) SDRs; Region: SDR_c; cd05233 1199187006016 NAD(P) binding site [chemical binding]; other site 1199187006017 active site 1199187006018 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1199187006019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187006020 S-adenosylmethionine binding site [chemical binding]; other site 1199187006021 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1199187006022 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1199187006023 putative oligomer interface [polypeptide binding]; other site 1199187006024 putative active site [active] 1199187006025 metal binding site [ion binding]; metal-binding site 1199187006026 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1199187006027 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187006028 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187006029 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1199187006030 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1199187006031 hypothetical protein; Provisional; Region: PRK06834 1199187006032 hypothetical protein; Provisional; Region: PRK07236 1199187006033 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1199187006034 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1199187006035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187006036 ATP binding site [chemical binding]; other site 1199187006037 putative Mg++ binding site [ion binding]; other site 1199187006038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187006039 nucleotide binding region [chemical binding]; other site 1199187006040 ATP-binding site [chemical binding]; other site 1199187006041 Helicase associated domain (HA2); Region: HA2; pfam04408 1199187006042 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1199187006043 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1199187006044 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1199187006045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1199187006046 metal binding site [ion binding]; metal-binding site 1199187006047 active site 1199187006048 I-site; other site 1199187006049 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187006050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187006051 substrate binding site [chemical binding]; other site 1199187006052 oxyanion hole (OAH) forming residues; other site 1199187006053 trimer interface [polypeptide binding]; other site 1199187006054 Cutinase; Region: Cutinase; pfam01083 1199187006055 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1199187006056 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1199187006057 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1199187006058 MOSC domain; Region: MOSC; pfam03473 1199187006059 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1199187006060 putative active site [active] 1199187006061 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1199187006062 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1199187006063 homodimer interface [polypeptide binding]; other site 1199187006064 active site 1199187006065 TDP-binding site; other site 1199187006066 acceptor substrate-binding pocket; other site 1199187006067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187006068 S-adenosylmethionine binding site [chemical binding]; other site 1199187006069 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1199187006070 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1199187006071 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1199187006072 iron-sulfur cluster [ion binding]; other site 1199187006073 [2Fe-2S] cluster binding site [ion binding]; other site 1199187006074 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1199187006075 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1199187006076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1199187006077 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1199187006078 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1199187006079 metal binding site 2 [ion binding]; metal-binding site 1199187006080 putative DNA binding helix; other site 1199187006081 metal binding site 1 [ion binding]; metal-binding site 1199187006082 dimer interface [polypeptide binding]; other site 1199187006083 structural Zn2+ binding site [ion binding]; other site 1199187006084 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1199187006085 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1199187006086 dimer interface [polypeptide binding]; other site 1199187006087 active site 1199187006088 heme binding site [chemical binding]; other site 1199187006089 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1199187006090 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1199187006091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187006092 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1199187006093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187006094 S-adenosylmethionine binding site [chemical binding]; other site 1199187006095 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1199187006096 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1199187006097 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1199187006098 Cutinase; Region: Cutinase; pfam01083 1199187006099 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1199187006100 active site 1199187006101 catalytic residues [active] 1199187006102 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1199187006103 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1199187006104 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1199187006105 NAD(P) binding site [chemical binding]; other site 1199187006106 catalytic residues [active] 1199187006107 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1199187006108 extended (e) SDRs; Region: SDR_e; cd08946 1199187006109 NAD(P) binding site [chemical binding]; other site 1199187006110 active site 1199187006111 substrate binding site [chemical binding]; other site 1199187006112 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187006113 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187006114 active site 1199187006115 YacP-like NYN domain; Region: NYN_YacP; cl01491 1199187006116 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1199187006117 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1199187006118 FMN binding site [chemical binding]; other site 1199187006119 substrate binding site [chemical binding]; other site 1199187006120 putative catalytic residue [active] 1199187006121 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1199187006122 dimer interface [polypeptide binding]; other site 1199187006123 catalytic triad [active] 1199187006124 peroxidatic and resolving cysteines [active] 1199187006125 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1199187006126 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1199187006127 conserved cys residue [active] 1199187006128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1199187006129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1199187006130 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1199187006131 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1199187006132 conserved cys residue [active] 1199187006133 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187006134 short chain dehydrogenase; Provisional; Region: PRK05867 1199187006135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187006136 NAD(P) binding site [chemical binding]; other site 1199187006137 active site 1199187006138 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1199187006139 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1199187006140 acyl-activating enzyme (AAE) consensus motif; other site 1199187006141 active site 1199187006142 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1199187006143 putative hydrophobic ligand binding site [chemical binding]; other site 1199187006144 protein interface [polypeptide binding]; other site 1199187006145 gate; other site 1199187006146 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1199187006147 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1199187006148 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1199187006149 tetramer interface [polypeptide binding]; other site 1199187006150 active site 1199187006151 Mg2+/Mn2+ binding site [ion binding]; other site 1199187006152 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1199187006153 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187006154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1199187006155 dimerization interface [polypeptide binding]; other site 1199187006156 putative DNA binding site [nucleotide binding]; other site 1199187006157 putative Zn2+ binding site [ion binding]; other site 1199187006158 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1199187006159 putative hydrophobic ligand binding site [chemical binding]; other site 1199187006160 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1199187006161 putative hydrophobic ligand binding site [chemical binding]; other site 1199187006162 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1199187006163 substrate binding site [chemical binding]; other site 1199187006164 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1199187006165 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1199187006166 Flavoprotein; Region: Flavoprotein; pfam02441 1199187006167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1199187006168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1199187006169 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1199187006170 putative dimerization interface [polypeptide binding]; other site 1199187006171 DoxX-like family; Region: DoxX_2; pfam13564 1199187006172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1199187006173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187006174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187006175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187006176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187006177 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1199187006178 Predicted membrane protein [Function unknown]; Region: COG1950 1199187006179 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187006180 putative sialic acid transporter; Region: 2A0112; TIGR00891 1199187006181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187006182 putative substrate translocation pore; other site 1199187006183 competence damage-inducible protein A; Provisional; Region: PRK00549 1199187006184 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1199187006185 putative MPT binding site; other site 1199187006186 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1199187006187 Domain of unknown function DUF77; Region: DUF77; cl00307 1199187006188 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1199187006189 putative active site [active] 1199187006190 dimerization interface [polypeptide binding]; other site 1199187006191 putative tRNAtyr binding site [nucleotide binding]; other site 1199187006192 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187006193 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187006194 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1199187006195 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1199187006196 NAD(P) binding site [chemical binding]; other site 1199187006197 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187006198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187006199 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187006200 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187006201 active site 1199187006202 Nitronate monooxygenase; Region: NMO; pfam03060 1199187006203 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1199187006204 FMN binding site [chemical binding]; other site 1199187006205 substrate binding site [chemical binding]; other site 1199187006206 putative catalytic residue [active] 1199187006207 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187006208 Cytochrome P450; Region: p450; cl12078 1199187006209 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1199187006210 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1199187006211 putative NAD(P) binding site [chemical binding]; other site 1199187006212 putative substrate binding site [chemical binding]; other site 1199187006213 catalytic Zn binding site [ion binding]; other site 1199187006214 structural Zn binding site [ion binding]; other site 1199187006215 YceI-like domain; Region: YceI; smart00867 1199187006216 Putative esterase; Region: Esterase; pfam00756 1199187006217 chorismate mutase; Provisional; Region: PRK09269 1199187006218 Chorismate mutase type II; Region: CM_2; cl00693 1199187006219 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1199187006220 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1199187006221 catalytic residue [active] 1199187006222 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1199187006223 hydrophobic ligand binding site; other site 1199187006224 short chain dehydrogenase; Provisional; Region: PRK08267 1199187006225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187006226 NAD(P) binding site [chemical binding]; other site 1199187006227 active site 1199187006228 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1199187006229 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187006230 Cytochrome P450; Region: p450; cl12078 1199187006231 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187006232 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187006233 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1199187006234 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1199187006235 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 1199187006236 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1199187006237 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187006238 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187006239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187006240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1199187006241 putative substrate translocation pore; other site 1199187006242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187006243 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1199187006244 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1199187006245 heme binding site [chemical binding]; other site 1199187006246 ferroxidase pore; other site 1199187006247 ferroxidase diiron center [ion binding]; other site 1199187006248 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1199187006249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187006250 substrate binding site [chemical binding]; other site 1199187006251 oxyanion hole (OAH) forming residues; other site 1199187006252 trimer interface [polypeptide binding]; other site 1199187006253 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1199187006254 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1199187006255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1199187006256 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1199187006257 dimerization interface [polypeptide binding]; other site 1199187006258 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1199187006259 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1199187006260 dimer interface [polypeptide binding]; other site 1199187006261 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1199187006262 catalytic triad [active] 1199187006263 peroxidatic and resolving cysteines [active] 1199187006264 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1199187006265 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187006266 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1199187006267 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1199187006268 active site 1199187006269 catalytic site [active] 1199187006270 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1199187006271 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1199187006272 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1199187006273 active site 1199187006274 substrate binding site [chemical binding]; other site 1199187006275 FMN binding site [chemical binding]; other site 1199187006276 putative catalytic residues [active] 1199187006277 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1199187006278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187006279 Walker A motif; other site 1199187006280 ATP binding site [chemical binding]; other site 1199187006281 Walker B motif; other site 1199187006282 arginine finger; other site 1199187006283 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1199187006284 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1199187006285 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1199187006286 helix-hairpin-helix signature motif; other site 1199187006287 Protein of unknown function DUF72; Region: DUF72; pfam01904 1199187006288 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1199187006289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187006290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187006291 hypothetical protein; Provisional; Region: PRK12320 1199187006292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187006293 NAD(P) binding site [chemical binding]; other site 1199187006294 active site 1199187006295 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1199187006296 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187006297 active site 1199187006298 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187006299 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187006300 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187006301 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187006302 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1199187006303 short chain dehydrogenase; Provisional; Region: PRK07825 1199187006304 classical (c) SDRs; Region: SDR_c; cd05233 1199187006305 NAD(P) binding site [chemical binding]; other site 1199187006306 active site 1199187006307 putative phosphoketolase; Provisional; Region: PRK05261 1199187006308 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1199187006309 TPP-binding site; other site 1199187006310 XFP C-terminal domain; Region: XFP_C; pfam09363 1199187006311 CAAX protease self-immunity; Region: Abi; pfam02517 1199187006312 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1199187006313 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1199187006314 putative NAD(P) binding site [chemical binding]; other site 1199187006315 putative substrate binding site [chemical binding]; other site 1199187006316 catalytic Zn binding site [ion binding]; other site 1199187006317 structural Zn binding site [ion binding]; other site 1199187006318 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1199187006319 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1199187006320 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1199187006321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187006322 Walker A/P-loop; other site 1199187006323 ATP binding site [chemical binding]; other site 1199187006324 Q-loop/lid; other site 1199187006325 ABC transporter signature motif; other site 1199187006326 Walker B; other site 1199187006327 D-loop; other site 1199187006328 H-loop/switch region; other site 1199187006329 TOBE domain; Region: TOBE; cl01440 1199187006330 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1199187006331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187006332 putative PBP binding loops; other site 1199187006333 ABC-ATPase subunit interface; other site 1199187006334 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1199187006335 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1199187006336 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1199187006337 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1199187006338 classical (c) SDRs; Region: SDR_c; cd05233 1199187006339 NAD(P) binding site [chemical binding]; other site 1199187006340 active site 1199187006341 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1199187006342 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187006343 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187006344 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1199187006345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187006346 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187006347 CoenzymeA binding site [chemical binding]; other site 1199187006348 subunit interaction site [polypeptide binding]; other site 1199187006349 PHB binding site; other site 1199187006350 Predicted transcriptional regulator [Transcription]; Region: COG3682 1199187006351 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1199187006352 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1199187006353 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1199187006354 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1199187006355 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1199187006356 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1199187006357 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1199187006358 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1199187006359 active site 1199187006360 acyl carrier protein; Validated; Region: PRK05883 1199187006361 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1199187006362 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187006363 acyl-activating enzyme (AAE) consensus motif; other site 1199187006364 AMP binding site [chemical binding]; other site 1199187006365 active site 1199187006366 CoA binding site [chemical binding]; other site 1199187006367 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187006368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187006369 active site 1199187006370 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1199187006371 Domain of unknown function DUF21; Region: DUF21; pfam01595 1199187006372 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1199187006373 Transporter associated domain; Region: CorC_HlyC; smart01091 1199187006374 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1199187006375 Domain of unknown function DUF21; Region: DUF21; pfam01595 1199187006376 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1199187006377 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1199187006378 active site 1199187006379 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1199187006380 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1199187006381 metal ion-dependent adhesion site (MIDAS); other site 1199187006382 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1199187006383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187006384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187006385 glycine dehydrogenase; Provisional; Region: PRK05367 1199187006386 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1199187006387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187006388 tetramer interface [polypeptide binding]; other site 1199187006389 catalytic residue [active] 1199187006390 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1199187006391 tetramer interface [polypeptide binding]; other site 1199187006392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187006393 catalytic residue [active] 1199187006394 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1199187006395 DNA binding residues [nucleotide binding] 1199187006396 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1199187006397 putative dimer interface [polypeptide binding]; other site 1199187006398 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1199187006399 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1199187006400 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1199187006401 DNA binding residues [nucleotide binding] 1199187006402 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187006403 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187006404 phosphopeptide binding site; other site 1199187006405 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1199187006406 lipoyl attachment site [posttranslational modification]; other site 1199187006407 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1199187006408 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1199187006409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1199187006410 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1199187006411 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1199187006412 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1199187006413 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1199187006414 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1199187006415 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1199187006416 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1199187006417 hypothetical protein; Validated; Region: PRK07121 1199187006418 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1199187006419 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1199187006420 metal binding site [ion binding]; metal-binding site 1199187006421 substrate binding site [chemical binding]; other site 1199187006422 dimer interface [polypeptide binding]; other site 1199187006423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187006424 Domain of unknown function (DUF385); Region: DUF385; cl04387 1199187006425 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1199187006426 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1199187006427 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1199187006428 MgtC family; Region: MgtC; pfam02308 1199187006429 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187006430 PPE family; Region: PPE; pfam00823 1199187006431 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187006432 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187006433 PPE family; Region: PPE; pfam00823 1199187006434 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187006435 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187006436 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187006437 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187006438 PPE family; Region: PPE; pfam00823 1199187006439 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187006440 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187006441 PPE family; Region: PPE; pfam00823 1199187006442 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187006443 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187006444 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187006445 PPE family; Region: PPE; pfam00823 1199187006446 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187006447 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187006448 PPE family; Region: PPE; pfam00823 1199187006449 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187006450 PE family; Region: PE; pfam00934 1199187006451 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1199187006452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1199187006453 TPR motif; other site 1199187006454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187006455 Walker A motif; other site 1199187006456 ATP binding site [chemical binding]; other site 1199187006457 Walker B motif; other site 1199187006458 arginine finger; other site 1199187006459 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1199187006460 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1199187006461 catalytic residues [active] 1199187006462 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1199187006463 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1199187006464 active site 1199187006465 catalytic residues [active] 1199187006466 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1199187006467 EspG family; Region: ESX-1_EspG; pfam14011 1199187006468 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1199187006469 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1199187006470 PE family; Region: PE; pfam00934 1199187006471 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187006472 PPE family; Region: PPE; pfam00823 1199187006473 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187006474 PPE family; Region: PPE; pfam00823 1199187006475 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187006476 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1199187006477 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187006478 Cytochrome P450; Region: p450; cl12078 1199187006479 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1199187006480 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187006481 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1199187006482 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187006483 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1199187006484 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1199187006485 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1199187006486 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187006487 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1199187006488 SnoaL-like domain; Region: SnoaL_4; pfam13577 1199187006489 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1199187006490 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1199187006491 Moco binding site; other site 1199187006492 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1199187006493 metal coordination site [ion binding]; other site 1199187006494 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1199187006495 hydrophobic ligand binding site; other site 1199187006496 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1199187006497 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1199187006498 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187006499 classical (c) SDRs; Region: SDR_c; cd05233 1199187006500 NAD(P) binding site [chemical binding]; other site 1199187006501 active site 1199187006502 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1199187006503 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1199187006504 tetramer interface [polypeptide binding]; other site 1199187006505 TPP-binding site [chemical binding]; other site 1199187006506 heterodimer interface [polypeptide binding]; other site 1199187006507 phosphorylation loop region [posttranslational modification] 1199187006508 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1199187006509 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1199187006510 alpha subunit interface [polypeptide binding]; other site 1199187006511 TPP binding site [chemical binding]; other site 1199187006512 heterodimer interface [polypeptide binding]; other site 1199187006513 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1199187006514 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1199187006515 E3 interaction surface; other site 1199187006516 lipoyl attachment site [posttranslational modification]; other site 1199187006517 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187006518 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187006519 substrate binding site [chemical binding]; other site 1199187006520 oxyanion hole (OAH) forming residues; other site 1199187006521 trimer interface [polypeptide binding]; other site 1199187006522 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187006523 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187006524 [2Fe-2S] cluster binding site [ion binding]; other site 1199187006525 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1199187006526 putative alpha subunit interface [polypeptide binding]; other site 1199187006527 putative active site [active] 1199187006528 putative substrate binding site [chemical binding]; other site 1199187006529 Fe binding site [ion binding]; other site 1199187006530 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1199187006531 enoyl-CoA hydratase; Provisional; Region: PRK06190 1199187006532 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187006533 substrate binding site [chemical binding]; other site 1199187006534 oxyanion hole (OAH) forming residues; other site 1199187006535 trimer interface [polypeptide binding]; other site 1199187006536 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1199187006537 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1199187006538 ATP binding site [chemical binding]; other site 1199187006539 Mg++ binding site [ion binding]; other site 1199187006540 motif III; other site 1199187006541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187006542 nucleotide binding region [chemical binding]; other site 1199187006543 ATP-binding site [chemical binding]; other site 1199187006544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187006545 S-adenosylmethionine binding site [chemical binding]; other site 1199187006546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187006547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187006548 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1199187006549 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187006550 active site 1199187006551 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187006552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187006553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187006554 Cutinase; Region: Cutinase; pfam01083 1199187006555 classical (c) SDRs; Region: SDR_c; cd05233 1199187006556 NAD(P) binding site [chemical binding]; other site 1199187006557 active site 1199187006558 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1199187006559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187006560 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1199187006561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187006562 DNA binding residues [nucleotide binding] 1199187006563 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1199187006564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187006565 Cytochrome P450; Region: p450; cl12078 1199187006566 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187006567 short chain dehydrogenase; Provisional; Region: PRK05854 1199187006568 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1199187006569 putative NAD(P) binding site [chemical binding]; other site 1199187006570 active site 1199187006571 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1199187006572 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1199187006573 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1199187006574 active site 1199187006575 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1199187006576 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1199187006577 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1199187006578 active site 1199187006579 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187006580 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187006581 active site 1199187006582 acyl-CoA synthetase; Provisional; Region: PRK13388 1199187006583 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187006584 acyl-activating enzyme (AAE) consensus motif; other site 1199187006585 AMP binding site [chemical binding]; other site 1199187006586 active site 1199187006587 CoA binding site [chemical binding]; other site 1199187006588 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187006589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187006590 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1199187006591 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187006592 thiolase; Provisional; Region: PRK06158 1199187006593 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187006594 active site 1199187006595 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1199187006596 putative active site [active] 1199187006597 putative catalytic site [active] 1199187006598 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1199187006599 active site 1199187006600 catalytic site [active] 1199187006601 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187006602 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187006603 active site 1199187006604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187006605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187006606 active site 1199187006607 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187006608 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187006609 phosphopeptide binding site; other site 1199187006610 YppG-like protein; Region: YppG; pfam14179 1199187006611 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187006612 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187006613 phosphopeptide binding site; other site 1199187006614 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1199187006615 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1199187006616 Walker A/P-loop; other site 1199187006617 ATP binding site [chemical binding]; other site 1199187006618 Q-loop/lid; other site 1199187006619 ABC transporter signature motif; other site 1199187006620 Walker B; other site 1199187006621 D-loop; other site 1199187006622 H-loop/switch region; other site 1199187006623 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1199187006624 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1199187006625 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187006626 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187006627 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1199187006628 classical (c) SDRs; Region: SDR_c; cd05233 1199187006629 NAD(P) binding site [chemical binding]; other site 1199187006630 active site 1199187006631 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1199187006632 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187006633 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187006634 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187006635 classical (c) SDRs; Region: SDR_c; cd05233 1199187006636 NAD(P) binding site [chemical binding]; other site 1199187006637 active site 1199187006638 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187006639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187006640 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1199187006641 classical (c) SDRs; Region: SDR_c; cd05233 1199187006642 NAD(P) binding site [chemical binding]; other site 1199187006643 active site 1199187006644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187006645 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187006646 active site 1199187006647 hypothetical protein; Validated; Region: PRK07121 1199187006648 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1199187006649 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1199187006650 Bacterial transcriptional regulator; Region: IclR; pfam01614 1199187006651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187006652 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187006653 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1199187006654 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 1199187006655 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1199187006656 NAD(P) binding site [chemical binding]; other site 1199187006657 homodimer interface [polypeptide binding]; other site 1199187006658 active site 1199187006659 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187006660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187006661 SnoaL-like domain; Region: SnoaL_4; pfam13577 1199187006662 hypothetical protein; Provisional; Region: PRK06194 1199187006663 classical (c) SDRs; Region: SDR_c; cd05233 1199187006664 NAD(P) binding site [chemical binding]; other site 1199187006665 active site 1199187006666 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187006667 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1199187006668 classical (c) SDRs; Region: SDR_c; cd05233 1199187006669 NAD(P) binding site [chemical binding]; other site 1199187006670 active site 1199187006671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187006672 short chain dehydrogenase; Provisional; Region: PRK08303 1199187006673 NAD(P) binding site [chemical binding]; other site 1199187006674 active site 1199187006675 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187006676 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1199187006677 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1199187006678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187006679 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1199187006680 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187006681 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187006682 active site 1199187006683 Predicted transcriptional regulators [Transcription]; Region: COG1695 1199187006684 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1199187006685 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1199187006686 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187006687 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1199187006688 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1199187006689 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1199187006690 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1199187006691 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1199187006692 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1199187006693 hypothetical protein; Provisional; Region: PRK14059 1199187006694 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1199187006695 benzoate transport; Region: 2A0115; TIGR00895 1199187006696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187006697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187006698 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1199187006699 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1199187006700 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1199187006701 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1199187006702 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1199187006703 active site 1199187006704 dimer interface [polypeptide binding]; other site 1199187006705 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1199187006706 Ligand Binding Site [chemical binding]; other site 1199187006707 Molecular Tunnel; other site 1199187006708 Condensation domain; Region: Condensation; pfam00668 1199187006709 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187006710 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1199187006711 acyl-activating enzyme (AAE) consensus motif; other site 1199187006712 AMP binding site [chemical binding]; other site 1199187006713 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187006714 Condensation domain; Region: Condensation; pfam00668 1199187006715 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1199187006716 Condensation domain; Region: Condensation; pfam00668 1199187006717 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187006718 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187006719 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1199187006720 acyl-activating enzyme (AAE) consensus motif; other site 1199187006721 AMP binding site [chemical binding]; other site 1199187006722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187006723 S-adenosylmethionine binding site [chemical binding]; other site 1199187006724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187006725 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187006726 Condensation domain; Region: Condensation; pfam00668 1199187006727 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187006728 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187006729 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187006730 acyl-activating enzyme (AAE) consensus motif; other site 1199187006731 AMP binding site [chemical binding]; other site 1199187006732 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187006733 Condensation domain; Region: Condensation; pfam00668 1199187006734 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187006735 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187006736 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187006737 acyl-activating enzyme (AAE) consensus motif; other site 1199187006738 AMP binding site [chemical binding]; other site 1199187006739 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187006740 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1199187006741 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187006742 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187006743 acyl-activating enzyme (AAE) consensus motif; other site 1199187006744 AMP binding site [chemical binding]; other site 1199187006745 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187006746 MbtH-like protein; Region: MbtH; pfam03621 1199187006747 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1199187006748 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1199187006749 GTP-binding protein Der; Reviewed; Region: PRK03003 1199187006750 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1199187006751 G1 box; other site 1199187006752 GTP/Mg2+ binding site [chemical binding]; other site 1199187006753 Switch I region; other site 1199187006754 G2 box; other site 1199187006755 Switch II region; other site 1199187006756 G3 box; other site 1199187006757 G4 box; other site 1199187006758 G5 box; other site 1199187006759 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1199187006760 G1 box; other site 1199187006761 GTP/Mg2+ binding site [chemical binding]; other site 1199187006762 Switch I region; other site 1199187006763 G2 box; other site 1199187006764 G3 box; other site 1199187006765 Switch II region; other site 1199187006766 G4 box; other site 1199187006767 G5 box; other site 1199187006768 cytidylate kinase; Provisional; Region: cmk; PRK00023 1199187006769 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1199187006770 CMP-binding site; other site 1199187006771 The sites determining sugar specificity; other site 1199187006772 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1199187006773 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1199187006774 RNA binding surface [nucleotide binding]; other site 1199187006775 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1199187006776 active site 1199187006777 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1199187006778 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1199187006779 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1199187006780 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1199187006781 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1199187006782 Magnesium ion binding site [ion binding]; other site 1199187006783 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1199187006784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1199187006785 S-adenosylmethionine binding site [chemical binding]; other site 1199187006786 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1199187006787 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187006788 active site 1199187006789 DNA binding site [nucleotide binding] 1199187006790 Int/Topo IB signature motif; other site 1199187006791 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1199187006792 dimer interface [polypeptide binding]; other site 1199187006793 ADP-ribose binding site [chemical binding]; other site 1199187006794 active site 1199187006795 nudix motif; other site 1199187006796 metal binding site [ion binding]; metal-binding site 1199187006797 CTP synthetase; Validated; Region: pyrG; PRK05380 1199187006798 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1199187006799 Catalytic site [active] 1199187006800 active site 1199187006801 UTP binding site [chemical binding]; other site 1199187006802 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1199187006803 active site 1199187006804 putative oxyanion hole; other site 1199187006805 catalytic triad [active] 1199187006806 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1199187006807 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1199187006808 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1199187006809 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1199187006810 DNA repair protein RecN; Region: recN; TIGR00634 1199187006811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187006812 Walker A/P-loop; other site 1199187006813 ATP binding site [chemical binding]; other site 1199187006814 Q-loop/lid; other site 1199187006815 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1199187006816 ABC transporter signature motif; other site 1199187006817 Walker B; other site 1199187006818 D-loop; other site 1199187006819 H-loop/switch region; other site 1199187006820 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1199187006821 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1199187006822 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1199187006823 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1199187006824 RNA binding surface [nucleotide binding]; other site 1199187006825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187006826 S-adenosylmethionine binding site [chemical binding]; other site 1199187006827 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1199187006828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187006829 active site 1199187006830 motif I; other site 1199187006831 motif II; other site 1199187006832 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1199187006833 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187006834 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1199187006835 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1199187006836 active site 1199187006837 HIGH motif; other site 1199187006838 dimer interface [polypeptide binding]; other site 1199187006839 KMSKS motif; other site 1199187006840 S4 RNA-binding domain; Region: S4; smart00363 1199187006841 RNA binding surface [nucleotide binding]; other site 1199187006842 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1199187006843 active site 1199187006844 DNA binding site [nucleotide binding] 1199187006845 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1199187006846 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1199187006847 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1199187006848 Walker A/P-loop; other site 1199187006849 ATP binding site [chemical binding]; other site 1199187006850 Q-loop/lid; other site 1199187006851 ABC transporter signature motif; other site 1199187006852 Walker B; other site 1199187006853 D-loop; other site 1199187006854 H-loop/switch region; other site 1199187006855 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1199187006856 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1199187006857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187006858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187006859 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1199187006860 acyl-CoA synthetase; Validated; Region: PRK07868 1199187006861 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187006862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187006863 active site 1199187006864 CoA binding site [chemical binding]; other site 1199187006865 AMP binding site [chemical binding]; other site 1199187006866 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1199187006867 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1199187006868 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1199187006869 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1199187006870 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1199187006871 short chain dehydrogenase; Provisional; Region: PRK07109 1199187006872 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1199187006873 putative NAD(P) binding site [chemical binding]; other site 1199187006874 active site 1199187006875 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 1199187006876 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1199187006877 putative active site pocket [active] 1199187006878 putative metal binding site [ion binding]; other site 1199187006879 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187006880 classical (c) SDRs; Region: SDR_c; cd05233 1199187006881 NAD(P) binding site [chemical binding]; other site 1199187006882 active site 1199187006883 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187006884 classical (c) SDRs; Region: SDR_c; cd05233 1199187006885 NAD(P) binding site [chemical binding]; other site 1199187006886 active site 1199187006887 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1199187006888 classical (c) SDRs; Region: SDR_c; cd05233 1199187006889 NAD(P) binding site [chemical binding]; other site 1199187006890 active site 1199187006891 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1199187006892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1199187006893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1199187006894 dimerization interface [polypeptide binding]; other site 1199187006895 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1199187006896 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1199187006897 ABC transporter; Region: ABC_tran_2; pfam12848 1199187006898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187006899 Walker A/P-loop; other site 1199187006900 ATP binding site [chemical binding]; other site 1199187006901 Q-loop/lid; other site 1199187006902 ABC transporter signature motif; other site 1199187006903 Walker B; other site 1199187006904 D-loop; other site 1199187006905 H-loop/switch region; other site 1199187006906 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187006907 Cytochrome P450; Region: p450; cl12078 1199187006908 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1199187006909 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1199187006910 malonyl-CoA binding site [chemical binding]; other site 1199187006911 dimer interface [polypeptide binding]; other site 1199187006912 active site 1199187006913 product binding site; other site 1199187006914 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187006915 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1199187006916 active site 1199187006917 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1199187006918 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187006919 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187006920 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187006921 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 1199187006922 active site 1199187006923 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1199187006924 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187006925 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1199187006926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187006927 Enoylreductase; Region: PKS_ER; smart00829 1199187006928 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1199187006929 NAD(P) binding site [chemical binding]; other site 1199187006930 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1199187006931 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1199187006932 putative NADP binding site [chemical binding]; other site 1199187006933 active site 1199187006934 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187006935 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1199187006936 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1199187006937 malonyl-CoA binding site [chemical binding]; other site 1199187006938 dimer interface [polypeptide binding]; other site 1199187006939 active site 1199187006940 product binding site; other site 1199187006941 argininosuccinate lyase; Provisional; Region: PRK00855 1199187006942 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1199187006943 active sites [active] 1199187006944 tetramer interface [polypeptide binding]; other site 1199187006945 argininosuccinate synthase; Provisional; Region: PRK13820 1199187006946 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1199187006947 ANP binding site [chemical binding]; other site 1199187006948 Substrate Binding Site II [chemical binding]; other site 1199187006949 Substrate Binding Site I [chemical binding]; other site 1199187006950 Arginine repressor [Transcription]; Region: ArgR; COG1438 1199187006951 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1199187006952 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1199187006953 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1199187006954 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1199187006955 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1199187006956 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1199187006957 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1199187006958 inhibitor-cofactor binding pocket; inhibition site 1199187006959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187006960 catalytic residue [active] 1199187006961 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1199187006962 feedback inhibition sensing region; other site 1199187006963 homohexameric interface [polypeptide binding]; other site 1199187006964 nucleotide binding site [chemical binding]; other site 1199187006965 N-acetyl-L-glutamate binding site [chemical binding]; other site 1199187006966 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1199187006967 heterotetramer interface [polypeptide binding]; other site 1199187006968 active site pocket [active] 1199187006969 cleavage site 1199187006970 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1199187006971 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1199187006972 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1199187006973 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1199187006974 putative tRNA-binding site [nucleotide binding]; other site 1199187006975 B3/4 domain; Region: B3_4; pfam03483 1199187006976 tRNA synthetase B5 domain; Region: B5; smart00874 1199187006977 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1199187006978 dimer interface [polypeptide binding]; other site 1199187006979 motif 1; other site 1199187006980 motif 3; other site 1199187006981 motif 2; other site 1199187006982 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1199187006983 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1199187006984 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1199187006985 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1199187006986 dimer interface [polypeptide binding]; other site 1199187006987 motif 1; other site 1199187006988 active site 1199187006989 motif 2; other site 1199187006990 motif 3; other site 1199187006991 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1199187006992 cyclase homology domain; Region: CHD; cd07302 1199187006993 nucleotidyl binding site; other site 1199187006994 metal binding site [ion binding]; metal-binding site 1199187006995 dimer interface [polypeptide binding]; other site 1199187006996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1199187006997 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1199187006998 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1199187006999 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1199187007000 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1199187007001 23S rRNA binding site [nucleotide binding]; other site 1199187007002 L21 binding site [polypeptide binding]; other site 1199187007003 L13 binding site [polypeptide binding]; other site 1199187007004 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1199187007005 translation initiation factor IF-3; Region: infC; TIGR00168 1199187007006 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1199187007007 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1199187007008 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1199187007009 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1199187007010 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1199187007011 dimer interface [polypeptide binding]; other site 1199187007012 putative anticodon binding site; other site 1199187007013 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1199187007014 motif 1; other site 1199187007015 dimer interface [polypeptide binding]; other site 1199187007016 active site 1199187007017 motif 2; other site 1199187007018 motif 3; other site 1199187007019 Predicted esterase [General function prediction only]; Region: COG0627 1199187007020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187007021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187007022 hypothetical protein; Provisional; Region: PRK07877 1199187007023 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1199187007024 ATP binding site [chemical binding]; other site 1199187007025 substrate interface [chemical binding]; other site 1199187007026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187007027 S-adenosylmethionine binding site [chemical binding]; other site 1199187007028 Cytochrome P450; Region: p450; cl12078 1199187007029 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187007030 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1199187007031 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1199187007032 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1199187007033 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1199187007034 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1199187007035 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1199187007036 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1199187007037 Ligand Binding Site [chemical binding]; other site 1199187007038 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1199187007039 MgtC family; Region: MgtC; pfam02308 1199187007040 excinuclease ABC subunit B; Provisional; Region: PRK05298 1199187007041 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187007042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187007043 nucleotide binding region [chemical binding]; other site 1199187007044 ATP-binding site [chemical binding]; other site 1199187007045 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1199187007046 UvrB/uvrC motif; Region: UVR; pfam02151 1199187007047 Protein kinase domain; Region: Pkinase; pfam00069 1199187007048 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1199187007049 active site 1199187007050 ATP binding site [chemical binding]; other site 1199187007051 substrate binding site [chemical binding]; other site 1199187007052 activation loop (A-loop); other site 1199187007053 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187007054 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187007055 phosphopeptide binding site; other site 1199187007056 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187007057 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187007058 phosphopeptide binding site; other site 1199187007059 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1199187007060 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1199187007061 Walker A/P-loop; other site 1199187007062 ATP binding site [chemical binding]; other site 1199187007063 Q-loop/lid; other site 1199187007064 ABC transporter signature motif; other site 1199187007065 Walker B; other site 1199187007066 D-loop; other site 1199187007067 H-loop/switch region; other site 1199187007068 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1199187007069 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1199187007070 Protein of unknown function (DUF402); Region: DUF402; cl00979 1199187007071 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1199187007072 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1199187007073 active site 1199187007074 DNA binding site [nucleotide binding] 1199187007075 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1199187007076 DNA binding site [nucleotide binding] 1199187007077 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1199187007078 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 1199187007079 DNA binding site [nucleotide binding] 1199187007080 catalytic residue [active] 1199187007081 H2TH interface [polypeptide binding]; other site 1199187007082 putative catalytic residues [active] 1199187007083 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1199187007084 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1199187007085 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1199187007086 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1199187007087 CoA-binding site [chemical binding]; other site 1199187007088 ATP-binding [chemical binding]; other site 1199187007089 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1199187007090 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1199187007091 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1199187007092 RNA binding site [nucleotide binding]; other site 1199187007093 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1199187007094 RNA binding site [nucleotide binding]; other site 1199187007095 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1199187007096 RNA binding site [nucleotide binding]; other site 1199187007097 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1199187007098 RNA binding site [nucleotide binding]; other site 1199187007099 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1199187007100 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1199187007101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187007102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187007103 5'-3' exonuclease; Region: 53EXOc; smart00475 1199187007104 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1199187007105 active site 1199187007106 metal binding site 1 [ion binding]; metal-binding site 1199187007107 putative 5' ssDNA interaction site; other site 1199187007108 metal binding site 3; metal-binding site 1199187007109 metal binding site 2 [ion binding]; metal-binding site 1199187007110 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1199187007111 putative DNA binding site [nucleotide binding]; other site 1199187007112 putative metal binding site [ion binding]; other site 1199187007113 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1199187007114 DNA polymerase I; Provisional; Region: PRK05755 1199187007115 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1199187007116 active site 1199187007117 DNA binding site [nucleotide binding] 1199187007118 catalytic site [active] 1199187007119 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1199187007120 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1199187007121 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187007122 lipid-transfer protein; Provisional; Region: PRK06059 1199187007123 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187007124 active site 1199187007125 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1199187007126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187007127 active site 1199187007128 phosphorylation site [posttranslational modification] 1199187007129 intermolecular recognition site; other site 1199187007130 dimerization interface [polypeptide binding]; other site 1199187007131 ANTAR domain; Region: ANTAR; pfam03861 1199187007132 Heme NO binding associated; Region: HNOBA; pfam07701 1199187007133 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1199187007134 cyclase homology domain; Region: CHD; cd07302 1199187007135 nucleotidyl binding site; other site 1199187007136 metal binding site [ion binding]; metal-binding site 1199187007137 dimer interface [polypeptide binding]; other site 1199187007138 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1199187007139 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1199187007140 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1199187007141 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1199187007142 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1199187007143 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1199187007144 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1199187007145 Walker A/P-loop; other site 1199187007146 ATP binding site [chemical binding]; other site 1199187007147 Q-loop/lid; other site 1199187007148 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1199187007149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187007150 Walker A/P-loop; other site 1199187007151 ATP binding site [chemical binding]; other site 1199187007152 Q-loop/lid; other site 1199187007153 ABC transporter signature motif; other site 1199187007154 Walker B; other site 1199187007155 D-loop; other site 1199187007156 H-loop/switch region; other site 1199187007157 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1199187007158 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1199187007159 active site 1199187007160 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1199187007161 catalytic triad [active] 1199187007162 dimer interface [polypeptide binding]; other site 1199187007163 pyruvate kinase; Provisional; Region: PRK06247 1199187007164 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1199187007165 domain interfaces; other site 1199187007166 active site 1199187007167 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1199187007168 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1199187007169 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1199187007170 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1199187007171 substrate binding site [chemical binding]; other site 1199187007172 active site 1199187007173 catalytic residues [active] 1199187007174 heterodimer interface [polypeptide binding]; other site 1199187007175 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1199187007176 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1199187007177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187007178 catalytic residue [active] 1199187007179 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1199187007180 active site 1199187007181 ribulose/triose binding site [chemical binding]; other site 1199187007182 phosphate binding site [ion binding]; other site 1199187007183 substrate (anthranilate) binding pocket [chemical binding]; other site 1199187007184 product (indole) binding pocket [chemical binding]; other site 1199187007185 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1199187007186 anthranilate synthase component I; Provisional; Region: PRK13571 1199187007187 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1199187007188 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1199187007189 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1199187007190 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1199187007191 catalytic triad [active] 1199187007192 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1199187007193 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1199187007194 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1199187007195 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1199187007196 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1199187007197 substrate binding site [chemical binding]; other site 1199187007198 glutamase interaction surface [polypeptide binding]; other site 1199187007199 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1199187007200 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1199187007201 active site 1199187007202 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1199187007203 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1199187007204 catalytic residues [active] 1199187007205 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1199187007206 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1199187007207 putative active site [active] 1199187007208 oxyanion strand; other site 1199187007209 catalytic triad [active] 1199187007210 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1199187007211 putative active site pocket [active] 1199187007212 4-fold oligomerization interface [polypeptide binding]; other site 1199187007213 metal binding residues [ion binding]; metal-binding site 1199187007214 3-fold/trimer interface [polypeptide binding]; other site 1199187007215 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1199187007216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187007217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187007218 homodimer interface [polypeptide binding]; other site 1199187007219 catalytic residue [active] 1199187007220 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1199187007221 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1199187007222 NAD binding site [chemical binding]; other site 1199187007223 dimerization interface [polypeptide binding]; other site 1199187007224 product binding site; other site 1199187007225 substrate binding site [chemical binding]; other site 1199187007226 zinc binding site [ion binding]; other site 1199187007227 catalytic residues [active] 1199187007228 Domain of unknown function (DUF385); Region: DUF385; cl04387 1199187007229 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1199187007230 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1199187007231 dimerization interface [polypeptide binding]; other site 1199187007232 active site 1199187007233 L-aspartate oxidase; Provisional; Region: PRK07804 1199187007234 L-aspartate oxidase; Provisional; Region: PRK06175 1199187007235 quinolinate synthetase; Provisional; Region: PRK09375 1199187007236 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1199187007237 nudix motif; other site 1199187007238 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1199187007239 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187007240 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187007241 Secretory lipase; Region: LIP; pfam03583 1199187007242 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1199187007243 biotin synthase; Validated; Region: PRK06256 1199187007244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1199187007245 FeS/SAM binding site; other site 1199187007246 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1199187007247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187007248 dimerization interface [polypeptide binding]; other site 1199187007249 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1199187007250 cyclase homology domain; Region: CHD; cd07302 1199187007251 nucleotidyl binding site; other site 1199187007252 metal binding site [ion binding]; metal-binding site 1199187007253 dimer interface [polypeptide binding]; other site 1199187007254 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1199187007255 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1199187007256 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1199187007257 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1199187007258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187007259 catalytic residue [active] 1199187007260 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1199187007261 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1199187007262 inhibitor-cofactor binding pocket; inhibition site 1199187007263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187007264 catalytic residue [active] 1199187007265 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1199187007266 NlpC/P60 family; Region: NLPC_P60; pfam00877 1199187007267 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187007268 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1199187007269 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1199187007270 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1199187007271 active site 1199187007272 catalytic site [active] 1199187007273 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1199187007274 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1199187007275 active site 1199187007276 catalytic site [active] 1199187007277 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1199187007278 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1199187007279 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1199187007280 catalytic site [active] 1199187007281 active site 1199187007282 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1199187007283 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1199187007284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187007285 DNA-binding site [nucleotide binding]; DNA binding site 1199187007286 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187007287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187007288 catalytic residue [active] 1199187007289 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1199187007290 threonine dehydratase; Validated; Region: PRK08639 1199187007291 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1199187007292 tetramer interface [polypeptide binding]; other site 1199187007293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187007294 catalytic residue [active] 1199187007295 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1199187007296 putative Ile/Val binding site [chemical binding]; other site 1199187007297 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1199187007298 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1199187007299 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1199187007300 putative acyl-acceptor binding pocket; other site 1199187007301 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1199187007302 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1199187007303 acyl-activating enzyme (AAE) consensus motif; other site 1199187007304 putative AMP binding site [chemical binding]; other site 1199187007305 putative active site [active] 1199187007306 putative CoA binding site [chemical binding]; other site 1199187007307 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1199187007308 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1199187007309 DNA binding residues [nucleotide binding] 1199187007310 putative dimer interface [polypeptide binding]; other site 1199187007311 putative metal binding residues [ion binding]; other site 1199187007312 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1199187007313 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1199187007314 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1199187007315 active site 1199187007316 PHP Thumb interface [polypeptide binding]; other site 1199187007317 metal binding site [ion binding]; metal-binding site 1199187007318 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1199187007319 generic binding surface II; other site 1199187007320 generic binding surface I; other site 1199187007321 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1199187007322 hydrophobic ligand binding site; other site 1199187007323 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1199187007324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187007325 NAD(P) binding site [chemical binding]; other site 1199187007326 active site 1199187007327 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1199187007328 apolar tunnel; other site 1199187007329 heme binding site [chemical binding]; other site 1199187007330 dimerization interface [polypeptide binding]; other site 1199187007331 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1199187007332 S-adenosylmethionine binding site [chemical binding]; other site 1199187007333 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1199187007334 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1199187007335 active site 1199187007336 lipoprotein signal peptidase; Provisional; Region: PRK14764 1199187007337 lipoprotein signal peptidase; Provisional; Region: PRK14787 1199187007338 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1199187007339 active site 1199187007340 homodimer interface [polypeptide binding]; other site 1199187007341 homotetramer interface [polypeptide binding]; other site 1199187007342 DNA polymerase IV; Provisional; Region: PRK03348 1199187007343 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1199187007344 active site 1199187007345 DNA binding site [nucleotide binding] 1199187007346 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1199187007347 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1199187007348 putative active site [active] 1199187007349 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1199187007350 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1199187007351 HIGH motif; other site 1199187007352 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1199187007353 active site 1199187007354 KMSKS motif; other site 1199187007355 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1199187007356 tRNA binding surface [nucleotide binding]; other site 1199187007357 anticodon binding site; other site 1199187007358 Nitronate monooxygenase; Region: NMO; pfam03060 1199187007359 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1199187007360 FMN binding site [chemical binding]; other site 1199187007361 substrate binding site [chemical binding]; other site 1199187007362 putative catalytic residue [active] 1199187007363 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187007364 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187007365 Condensation domain; Region: Condensation; pfam00668 1199187007366 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187007367 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1199187007368 acyl-activating enzyme (AAE) consensus motif; other site 1199187007369 AMP binding site [chemical binding]; other site 1199187007370 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187007371 Condensation domain; Region: Condensation; pfam00668 1199187007372 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1199187007373 Condensation domain; Region: Condensation; pfam00668 1199187007374 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187007375 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187007376 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1199187007377 acyl-activating enzyme (AAE) consensus motif; other site 1199187007378 AMP binding site [chemical binding]; other site 1199187007379 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187007380 Condensation domain; Region: Condensation; pfam00668 1199187007381 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1199187007382 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1199187007383 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1199187007384 acyl-activating enzyme (AAE) consensus motif; other site 1199187007385 AMP binding site [chemical binding]; other site 1199187007386 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1199187007387 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1199187007388 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1199187007389 putative NAD(P) binding site [chemical binding]; other site 1199187007390 active site 1199187007391 putative substrate binding site [chemical binding]; other site 1199187007392 MbtH-like protein; Region: MbtH; pfam03621 1199187007393 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187007394 Transport protein; Region: actII; TIGR00833 1199187007395 Transport protein; Region: actII; TIGR00833 1199187007396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187007397 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1199187007398 Walker A/P-loop; other site 1199187007399 ATP binding site [chemical binding]; other site 1199187007400 Q-loop/lid; other site 1199187007401 ABC transporter signature motif; other site 1199187007402 Walker B; other site 1199187007403 D-loop; other site 1199187007404 H-loop/switch region; other site 1199187007405 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1199187007406 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1199187007407 daunorubicin resistance protein C; Region: drrC; TIGR01248 1199187007408 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187007409 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1199187007410 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1199187007411 metal-binding site 1199187007412 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1199187007413 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1199187007414 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1199187007415 NADP binding site [chemical binding]; other site 1199187007416 active site 1199187007417 putative substrate binding site [chemical binding]; other site 1199187007418 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1199187007419 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1199187007420 NADP-binding site; other site 1199187007421 homotetramer interface [polypeptide binding]; other site 1199187007422 substrate binding site [chemical binding]; other site 1199187007423 homodimer interface [polypeptide binding]; other site 1199187007424 active site 1199187007425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1199187007426 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1199187007427 Beta-lactamase; Region: Beta-lactamase; pfam00144 1199187007428 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1199187007429 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1199187007430 Walker A; other site 1199187007431 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1199187007432 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1199187007433 active site 1199187007434 substrate binding site [chemical binding]; other site 1199187007435 coenzyme B12 binding site [chemical binding]; other site 1199187007436 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1199187007437 B12 binding site [chemical binding]; other site 1199187007438 cobalt ligand [ion binding]; other site 1199187007439 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1199187007440 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1199187007441 heterodimer interface [polypeptide binding]; other site 1199187007442 substrate interaction site [chemical binding]; other site 1199187007443 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1199187007444 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1199187007445 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1199187007446 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1199187007447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187007448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187007449 dimerization interface [polypeptide binding]; other site 1199187007450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187007451 dimer interface [polypeptide binding]; other site 1199187007452 phosphorylation site [posttranslational modification] 1199187007453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187007454 Mg2+ binding site [ion binding]; other site 1199187007455 G-X-G motif; other site 1199187007456 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187007457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187007458 active site 1199187007459 phosphorylation site [posttranslational modification] 1199187007460 intermolecular recognition site; other site 1199187007461 dimerization interface [polypeptide binding]; other site 1199187007462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187007463 DNA binding site [nucleotide binding] 1199187007464 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1199187007465 PknH-like extracellular domain; Region: PknH_C; pfam14032 1199187007466 DoxX-like family; Region: DoxX_2; pfam13564 1199187007467 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1199187007468 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1199187007469 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1199187007470 ferrochelatase; Reviewed; Region: hemH; PRK00035 1199187007471 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1199187007472 C-terminal domain interface [polypeptide binding]; other site 1199187007473 active site 1199187007474 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1199187007475 active site 1199187007476 N-terminal domain interface [polypeptide binding]; other site 1199187007477 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1199187007478 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1199187007479 NAD binding site [chemical binding]; other site 1199187007480 homotetramer interface [polypeptide binding]; other site 1199187007481 homodimer interface [polypeptide binding]; other site 1199187007482 substrate binding site [chemical binding]; other site 1199187007483 active site 1199187007484 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1199187007485 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1199187007486 NAD(P) binding site [chemical binding]; other site 1199187007487 homotetramer interface [polypeptide binding]; other site 1199187007488 homodimer interface [polypeptide binding]; other site 1199187007489 active site 1199187007490 hypothetical protein; Provisional; Region: PRK13685 1199187007491 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1199187007492 metal ion-dependent adhesion site (MIDAS); other site 1199187007493 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1199187007494 Protein of unknown function DUF58; Region: DUF58; pfam01882 1199187007495 MoxR-like ATPases [General function prediction only]; Region: COG0714 1199187007496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187007497 Walker A motif; other site 1199187007498 ATP binding site [chemical binding]; other site 1199187007499 Walker B motif; other site 1199187007500 arginine finger; other site 1199187007501 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1199187007502 NlpC/P60 family; Region: NLPC_P60; pfam00877 1199187007503 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1199187007504 NlpC/P60 family; Region: NLPC_P60; pfam00877 1199187007505 aconitate hydratase; Validated; Region: PRK09277 1199187007506 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1199187007507 substrate binding site [chemical binding]; other site 1199187007508 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1199187007509 ligand binding site [chemical binding]; other site 1199187007510 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1199187007511 substrate binding site [chemical binding]; other site 1199187007512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187007513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187007514 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1199187007515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187007516 Walker A/P-loop; other site 1199187007517 ATP binding site [chemical binding]; other site 1199187007518 Q-loop/lid; other site 1199187007519 ABC transporter signature motif; other site 1199187007520 Walker B; other site 1199187007521 D-loop; other site 1199187007522 H-loop/switch region; other site 1199187007523 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1199187007524 enoyl-CoA hydratase; Provisional; Region: PRK05864 1199187007525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187007526 substrate binding site [chemical binding]; other site 1199187007527 oxyanion hole (OAH) forming residues; other site 1199187007528 trimer interface [polypeptide binding]; other site 1199187007529 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1199187007530 catalytic residues [active] 1199187007531 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1199187007532 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1199187007533 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187007534 active site 1199187007535 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1199187007536 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1199187007537 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1199187007538 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1199187007539 trimerization site [polypeptide binding]; other site 1199187007540 active site 1199187007541 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1199187007542 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1199187007543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187007544 catalytic residue [active] 1199187007545 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1199187007546 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1199187007547 Walker A/P-loop; other site 1199187007548 ATP binding site [chemical binding]; other site 1199187007549 Q-loop/lid; other site 1199187007550 ABC transporter signature motif; other site 1199187007551 Walker B; other site 1199187007552 D-loop; other site 1199187007553 H-loop/switch region; other site 1199187007554 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1199187007555 FeS assembly protein SufD; Region: sufD; TIGR01981 1199187007556 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1199187007557 FeS assembly protein SufB; Region: sufB; TIGR01980 1199187007558 Predicted transcriptional regulator [Transcription]; Region: COG2345 1199187007559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1199187007560 putative DNA binding site [nucleotide binding]; other site 1199187007561 putative Zn2+ binding site [ion binding]; other site 1199187007562 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1199187007563 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1199187007564 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1199187007565 Walker A/P-loop; other site 1199187007566 ATP binding site [chemical binding]; other site 1199187007567 Q-loop/lid; other site 1199187007568 ABC transporter signature motif; other site 1199187007569 Walker B; other site 1199187007570 D-loop; other site 1199187007571 H-loop/switch region; other site 1199187007572 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1199187007573 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1199187007574 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1199187007575 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1199187007576 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1199187007577 NADP binding site [chemical binding]; other site 1199187007578 dimer interface [polypeptide binding]; other site 1199187007579 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1199187007580 UbiA prenyltransferase family; Region: UbiA; pfam01040 1199187007581 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1199187007582 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1199187007583 TPP-binding site [chemical binding]; other site 1199187007584 dimer interface [polypeptide binding]; other site 1199187007585 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1199187007586 PYR/PP interface [polypeptide binding]; other site 1199187007587 dimer interface [polypeptide binding]; other site 1199187007588 TPP binding site [chemical binding]; other site 1199187007589 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1199187007590 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1199187007591 putative active site [active] 1199187007592 transaldolase; Provisional; Region: PRK03903 1199187007593 catalytic residue [active] 1199187007594 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1199187007595 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1199187007596 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1199187007597 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1199187007598 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1199187007599 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1199187007600 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1199187007601 putative active site [active] 1199187007602 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1199187007603 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1199187007604 putative active site [active] 1199187007605 Zn binding site [ion binding]; other site 1199187007606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187007607 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187007608 active site 1199187007609 catalytic tetrad [active] 1199187007610 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1199187007611 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1199187007612 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1199187007613 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1199187007614 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187007615 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1199187007616 Preprotein translocase SecG subunit; Region: SecG; cl09123 1199187007617 triosephosphate isomerase; Provisional; Region: PRK14567 1199187007618 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1199187007619 substrate binding site [chemical binding]; other site 1199187007620 dimer interface [polypeptide binding]; other site 1199187007621 catalytic triad [active] 1199187007622 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1199187007623 Phosphoglycerate kinase; Region: PGK; pfam00162 1199187007624 substrate binding site [chemical binding]; other site 1199187007625 hinge regions; other site 1199187007626 ADP binding site [chemical binding]; other site 1199187007627 catalytic site [active] 1199187007628 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1199187007629 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1199187007630 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1199187007631 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1199187007632 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187007633 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1199187007634 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187007635 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1199187007636 putative acyl-acceptor binding pocket; other site 1199187007637 acyl-CoA synthetase; Provisional; Region: PRK13382 1199187007638 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1199187007639 acyl-activating enzyme (AAE) consensus motif; other site 1199187007640 putative AMP binding site [chemical binding]; other site 1199187007641 putative active site [active] 1199187007642 putative CoA binding site [chemical binding]; other site 1199187007643 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187007644 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187007645 substrate binding pocket [chemical binding]; other site 1199187007646 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187007647 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1199187007648 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187007649 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187007650 PPE family; Region: PPE; pfam00823 1199187007651 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187007652 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187007653 PPE family; Region: PPE; pfam00823 1199187007654 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187007655 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187007656 PPE family; Region: PPE; pfam00823 1199187007657 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187007658 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1199187007659 MULE transposase domain; Region: MULE; pfam10551 1199187007660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1199187007661 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1199187007662 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1199187007663 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1199187007664 phosphate binding site [ion binding]; other site 1199187007665 putative substrate binding pocket [chemical binding]; other site 1199187007666 dimer interface [polypeptide binding]; other site 1199187007667 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1199187007668 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1199187007669 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1199187007670 GIY-YIG motif/motif A; other site 1199187007671 active site 1199187007672 catalytic site [active] 1199187007673 putative DNA binding site [nucleotide binding]; other site 1199187007674 metal binding site [ion binding]; metal-binding site 1199187007675 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1199187007676 Helix-hairpin-helix motif; Region: HHH; pfam00633 1199187007677 helix-hairpin-helix signature motif; other site 1199187007678 Cupin superfamily protein; Region: Cupin_4; pfam08007 1199187007679 Cupin-like domain; Region: Cupin_8; pfam13621 1199187007680 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187007681 PPE family; Region: PPE; pfam00823 1199187007682 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1199187007683 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1199187007684 homopentamer interface [polypeptide binding]; other site 1199187007685 active site 1199187007686 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1199187007687 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1199187007688 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1199187007689 dimerization interface [polypeptide binding]; other site 1199187007690 active site 1199187007691 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1199187007692 Lumazine binding domain; Region: Lum_binding; pfam00677 1199187007693 Lumazine binding domain; Region: Lum_binding; pfam00677 1199187007694 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1199187007695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187007696 putative substrate translocation pore; other site 1199187007697 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1199187007698 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1199187007699 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1199187007700 catalytic motif [active] 1199187007701 Zn binding site [ion binding]; other site 1199187007702 RibD C-terminal domain; Region: RibD_C; pfam01872 1199187007703 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1199187007704 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1199187007705 substrate binding site [chemical binding]; other site 1199187007706 hexamer interface [polypeptide binding]; other site 1199187007707 metal binding site [ion binding]; metal-binding site 1199187007708 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1199187007709 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1199187007710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187007711 S-adenosylmethionine binding site [chemical binding]; other site 1199187007712 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1199187007713 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1199187007714 putative active site [active] 1199187007715 substrate binding site [chemical binding]; other site 1199187007716 putative cosubstrate binding site; other site 1199187007717 catalytic site [active] 1199187007718 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1199187007719 substrate binding site [chemical binding]; other site 1199187007720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187007721 S-adenosylmethionine binding site [chemical binding]; other site 1199187007722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1199187007723 MarR family; Region: MarR; pfam01047 1199187007724 primosome assembly protein PriA; Provisional; Region: PRK14873 1199187007725 Predicted membrane protein [Function unknown]; Region: COG3714 1199187007726 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187007727 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187007728 substrate binding pocket [chemical binding]; other site 1199187007729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187007730 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187007731 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1199187007732 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1199187007733 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1199187007734 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1199187007735 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1199187007736 Flavoprotein; Region: Flavoprotein; pfam02441 1199187007737 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1199187007738 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1199187007739 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1199187007740 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1199187007741 catalytic site [active] 1199187007742 G-X2-G-X-G-K; other site 1199187007743 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1199187007744 DNA binding residues [nucleotide binding] 1199187007745 TOBE domain; Region: TOBE; cl01440 1199187007746 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1199187007747 active site 1199187007748 dimer interface [polypeptide binding]; other site 1199187007749 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1199187007750 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1199187007751 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1199187007752 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1199187007753 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1199187007754 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1199187007755 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1199187007756 IMP binding site; other site 1199187007757 dimer interface [polypeptide binding]; other site 1199187007758 interdomain contacts; other site 1199187007759 partial ornithine binding site; other site 1199187007760 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1199187007761 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1199187007762 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1199187007763 catalytic site [active] 1199187007764 subunit interface [polypeptide binding]; other site 1199187007765 dihydroorotase; Validated; Region: pyrC; PRK09357 1199187007766 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187007767 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1199187007768 active site 1199187007769 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1199187007770 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1199187007771 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1199187007772 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1199187007773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1199187007774 active site 1199187007775 Beta-lactamase; Region: Beta-lactamase; pfam00144 1199187007776 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1199187007777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1199187007778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1199187007779 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1199187007780 L-aspartate oxidase; Provisional; Region: PRK06175 1199187007781 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1199187007782 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1199187007783 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1199187007784 Walker A/P-loop; other site 1199187007785 ATP binding site [chemical binding]; other site 1199187007786 Q-loop/lid; other site 1199187007787 ABC transporter signature motif; other site 1199187007788 Walker B; other site 1199187007789 D-loop; other site 1199187007790 H-loop/switch region; other site 1199187007791 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1199187007792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187007793 dimer interface [polypeptide binding]; other site 1199187007794 conserved gate region; other site 1199187007795 putative PBP binding loops; other site 1199187007796 ABC-ATPase subunit interface; other site 1199187007797 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1199187007798 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1199187007799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187007800 DNA-binding site [nucleotide binding]; DNA binding site 1199187007801 UTRA domain; Region: UTRA; pfam07702 1199187007802 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1199187007803 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1199187007804 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1199187007805 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1199187007806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187007807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187007808 active site 1199187007809 phosphorylation site [posttranslational modification] 1199187007810 intermolecular recognition site; other site 1199187007811 dimerization interface [polypeptide binding]; other site 1199187007812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187007813 DNA binding site [nucleotide binding] 1199187007814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187007815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187007816 dimerization interface [polypeptide binding]; other site 1199187007817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187007818 dimer interface [polypeptide binding]; other site 1199187007819 phosphorylation site [posttranslational modification] 1199187007820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187007821 ATP binding site [chemical binding]; other site 1199187007822 Mg2+ binding site [ion binding]; other site 1199187007823 G-X-G motif; other site 1199187007824 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1199187007825 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187007826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187007827 catalytic residue [active] 1199187007828 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1199187007829 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1199187007830 putative RNA binding site [nucleotide binding]; other site 1199187007831 elongation factor P; Validated; Region: PRK00529 1199187007832 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1199187007833 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1199187007834 RNA binding site [nucleotide binding]; other site 1199187007835 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1199187007836 RNA binding site [nucleotide binding]; other site 1199187007837 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1199187007838 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1199187007839 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1199187007840 active site 1199187007841 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1199187007842 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1199187007843 trimer interface [polypeptide binding]; other site 1199187007844 active site 1199187007845 dimer interface [polypeptide binding]; other site 1199187007846 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1199187007847 active site 1199187007848 dimer interface [polypeptide binding]; other site 1199187007849 metal binding site [ion binding]; metal-binding site 1199187007850 shikimate kinase; Reviewed; Region: aroK; PRK00131 1199187007851 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1199187007852 ADP binding site [chemical binding]; other site 1199187007853 magnesium binding site [ion binding]; other site 1199187007854 putative shikimate binding site; other site 1199187007855 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1199187007856 chorismate synthase; Validated; Region: PRK05382 1199187007857 Tetramer interface [polypeptide binding]; other site 1199187007858 active site 1199187007859 FMN-binding site [chemical binding]; other site 1199187007860 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1199187007861 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1199187007862 Walker A/P-loop; other site 1199187007863 ATP binding site [chemical binding]; other site 1199187007864 Q-loop/lid; other site 1199187007865 ABC transporter signature motif; other site 1199187007866 Walker B; other site 1199187007867 D-loop; other site 1199187007868 H-loop/switch region; other site 1199187007869 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1199187007870 Walker A/P-loop; other site 1199187007871 ATP binding site [chemical binding]; other site 1199187007872 Q-loop/lid; other site 1199187007873 ABC transporter signature motif; other site 1199187007874 Walker B; other site 1199187007875 D-loop; other site 1199187007876 H-loop/switch region; other site 1199187007877 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1199187007878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187007879 dimer interface [polypeptide binding]; other site 1199187007880 conserved gate region; other site 1199187007881 putative PBP binding loops; other site 1199187007882 ABC-ATPase subunit interface; other site 1199187007883 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1199187007884 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1199187007885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187007886 active site 1199187007887 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187007888 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1199187007889 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1199187007890 active site 1199187007891 non-prolyl cis peptide bond; other site 1199187007892 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1199187007893 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1199187007894 active site 1199187007895 dimer interface [polypeptide binding]; other site 1199187007896 non-prolyl cis peptide bond; other site 1199187007897 insertion regions; other site 1199187007898 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1199187007899 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1199187007900 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1199187007901 NAD(P) binding site [chemical binding]; other site 1199187007902 shikimate binding site; other site 1199187007903 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1199187007904 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1199187007905 dimerization interface [polypeptide binding]; other site 1199187007906 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1199187007907 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1199187007908 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1199187007909 motif 1; other site 1199187007910 active site 1199187007911 motif 2; other site 1199187007912 motif 3; other site 1199187007913 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1199187007914 DHHA1 domain; Region: DHHA1; pfam02272 1199187007915 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1199187007916 recombination factor protein RarA; Reviewed; Region: PRK13342 1199187007917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187007918 Walker A motif; other site 1199187007919 ATP binding site [chemical binding]; other site 1199187007920 Walker B motif; other site 1199187007921 arginine finger; other site 1199187007922 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1199187007923 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1199187007924 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1199187007925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1199187007926 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1199187007927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1199187007928 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1199187007929 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1199187007930 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1199187007931 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1199187007932 Protein of unknown function (DUF419); Region: DUF419; cl15265 1199187007933 Predicted membrane protein [Function unknown]; Region: COG4129 1199187007934 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1199187007935 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1199187007936 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1199187007937 dimer interface [polypeptide binding]; other site 1199187007938 anticodon binding site; other site 1199187007939 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1199187007940 homodimer interface [polypeptide binding]; other site 1199187007941 motif 1; other site 1199187007942 active site 1199187007943 motif 2; other site 1199187007944 GAD domain; Region: GAD; pfam02938 1199187007945 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1199187007946 active site 1199187007947 motif 3; other site 1199187007948 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1199187007949 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1199187007950 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1199187007951 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1199187007952 putative hydrophobic ligand binding site [chemical binding]; other site 1199187007953 protein interface [polypeptide binding]; other site 1199187007954 gate; other site 1199187007955 Predicted metalloprotease [General function prediction only]; Region: COG2321 1199187007956 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1199187007957 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1199187007958 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1199187007959 inhibitor site; inhibition site 1199187007960 active site 1199187007961 dimer interface [polypeptide binding]; other site 1199187007962 catalytic residue [active] 1199187007963 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1199187007964 intersubunit interface [polypeptide binding]; other site 1199187007965 active site 1199187007966 Zn2+ binding site [ion binding]; other site 1199187007967 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1199187007968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187007969 non-specific DNA binding site [nucleotide binding]; other site 1199187007970 salt bridge; other site 1199187007971 sequence-specific DNA binding site [nucleotide binding]; other site 1199187007972 Cupin domain; Region: Cupin_2; pfam07883 1199187007973 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1199187007974 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1199187007975 active site 1199187007976 metal binding site [ion binding]; metal-binding site 1199187007977 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1199187007978 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1199187007979 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187007980 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187007981 active site 1199187007982 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1199187007983 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1199187007984 dimer interface [polypeptide binding]; other site 1199187007985 motif 1; other site 1199187007986 active site 1199187007987 motif 2; other site 1199187007988 motif 3; other site 1199187007989 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1199187007990 anticodon binding site; other site 1199187007991 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1199187007992 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1199187007993 active site 1199187007994 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1199187007995 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1199187007996 active site 1199187007997 ATP binding site [chemical binding]; other site 1199187007998 substrate binding site [chemical binding]; other site 1199187007999 activation loop (A-loop); other site 1199187008000 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1199187008001 active site 1199187008002 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 1199187008003 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187008004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187008005 Integrase core domain; Region: rve; pfam00665 1199187008006 Integrase core domain; Region: rve_3; pfam13683 1199187008007 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1199187008008 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1199187008009 Zn2+ binding site [ion binding]; other site 1199187008010 Mg2+ binding site [ion binding]; other site 1199187008011 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1199187008012 synthetase active site [active] 1199187008013 NTP binding site [chemical binding]; other site 1199187008014 metal binding site [ion binding]; metal-binding site 1199187008015 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1199187008016 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1199187008017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1199187008018 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1199187008019 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1199187008020 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1199187008021 Protein export membrane protein; Region: SecD_SecF; pfam02355 1199187008022 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1199187008023 Protein export membrane protein; Region: SecD_SecF; cl14618 1199187008024 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1199187008025 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1199187008026 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1199187008027 inhibitor-cofactor binding pocket; inhibition site 1199187008028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187008029 catalytic residue [active] 1199187008030 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1199187008031 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187008032 acyl-activating enzyme (AAE) consensus motif; other site 1199187008033 AMP binding site [chemical binding]; other site 1199187008034 active site 1199187008035 CoA binding site [chemical binding]; other site 1199187008036 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187008037 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1199187008038 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1199187008039 putative NAD(P) binding site [chemical binding]; other site 1199187008040 active site 1199187008041 putative substrate binding site [chemical binding]; other site 1199187008042 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1199187008043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187008044 Walker A motif; other site 1199187008045 ATP binding site [chemical binding]; other site 1199187008046 Walker B motif; other site 1199187008047 arginine finger; other site 1199187008048 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1199187008049 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1199187008050 RuvA N terminal domain; Region: RuvA_N; pfam01330 1199187008051 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1199187008052 active site 1199187008053 putative DNA-binding cleft [nucleotide binding]; other site 1199187008054 dimer interface [polypeptide binding]; other site 1199187008055 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1199187008056 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1199187008057 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1199187008058 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187008059 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187008060 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1199187008061 spermidine synthase; Provisional; Region: PRK03612 1199187008062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187008063 hypothetical protein; Validated; Region: PRK00110 1199187008064 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1199187008065 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1199187008066 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1199187008067 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1199187008068 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1199187008069 cystathionine gamma-synthase; Provisional; Region: PRK07811 1199187008070 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1199187008071 homodimer interface [polypeptide binding]; other site 1199187008072 substrate-cofactor binding pocket; other site 1199187008073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187008074 catalytic residue [active] 1199187008075 RDD family; Region: RDD; pfam06271 1199187008076 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1199187008077 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1199187008078 dimer interface [polypeptide binding]; other site 1199187008079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187008080 catalytic residue [active] 1199187008081 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1199187008082 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1199187008083 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1199187008084 substrate binding pocket [chemical binding]; other site 1199187008085 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1199187008086 active site 1199187008087 catalytic triad [active] 1199187008088 oxyanion hole [active] 1199187008089 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1199187008090 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1199187008091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187008092 substrate binding site [chemical binding]; other site 1199187008093 oxyanion hole (OAH) forming residues; other site 1199187008094 trimer interface [polypeptide binding]; other site 1199187008095 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1199187008096 enoyl-CoA hydratase; Provisional; Region: PRK05862 1199187008097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187008098 substrate binding site [chemical binding]; other site 1199187008099 oxyanion hole (OAH) forming residues; other site 1199187008100 trimer interface [polypeptide binding]; other site 1199187008101 Predicted membrane protein [Function unknown]; Region: COG4425 1199187008102 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1199187008103 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1199187008104 active site residue [active] 1199187008105 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1199187008106 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1199187008107 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1199187008108 active site 1199187008109 nucleophile elbow; other site 1199187008110 Patatin-like phospholipase; Region: Patatin; pfam01734 1199187008111 nucleophile elbow; other site 1199187008112 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1199187008113 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1199187008114 putative active site [active] 1199187008115 putative dimer interface [polypeptide binding]; other site 1199187008116 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1199187008117 putative hydrophobic ligand binding site [chemical binding]; other site 1199187008118 protein interface [polypeptide binding]; other site 1199187008119 gate; other site 1199187008120 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1199187008121 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1199187008122 dimer interface [polypeptide binding]; other site 1199187008123 acyl-activating enzyme (AAE) consensus motif; other site 1199187008124 putative active site [active] 1199187008125 AMP binding site [chemical binding]; other site 1199187008126 putative CoA binding site [chemical binding]; other site 1199187008127 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1199187008128 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1199187008129 Domain of unknown function (DUF427); Region: DUF427; cl00998 1199187008130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1199187008131 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1199187008132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187008133 S-adenosylmethionine binding site [chemical binding]; other site 1199187008134 PE family; Region: PE; pfam00934 1199187008135 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187008136 PPE family; Region: PPE; pfam00823 1199187008137 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1199187008138 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1199187008139 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187008140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187008141 active site 1199187008142 phosphorylation site [posttranslational modification] 1199187008143 intermolecular recognition site; other site 1199187008144 dimerization interface [polypeptide binding]; other site 1199187008145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187008146 DNA binding site [nucleotide binding] 1199187008147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187008148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187008149 dimer interface [polypeptide binding]; other site 1199187008150 phosphorylation site [posttranslational modification] 1199187008151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187008152 ATP binding site [chemical binding]; other site 1199187008153 Mg2+ binding site [ion binding]; other site 1199187008154 G-X-G motif; other site 1199187008155 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1199187008156 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1199187008157 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1199187008158 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1199187008159 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1199187008160 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1199187008161 Ligand Binding Site [chemical binding]; other site 1199187008162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187008163 dimer interface [polypeptide binding]; other site 1199187008164 phosphorylation site [posttranslational modification] 1199187008165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187008166 ATP binding site [chemical binding]; other site 1199187008167 Mg2+ binding site [ion binding]; other site 1199187008168 G-X-G motif; other site 1199187008169 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1199187008170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187008171 active site 1199187008172 phosphorylation site [posttranslational modification] 1199187008173 intermolecular recognition site; other site 1199187008174 dimerization interface [polypeptide binding]; other site 1199187008175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187008176 DNA binding site [nucleotide binding] 1199187008177 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1199187008178 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1199187008179 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1199187008180 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1199187008181 Septum formation initiator; Region: DivIC; pfam04977 1199187008182 enolase; Provisional; Region: eno; PRK00077 1199187008183 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1199187008184 dimer interface [polypeptide binding]; other site 1199187008185 metal binding site [ion binding]; metal-binding site 1199187008186 substrate binding pocket [chemical binding]; other site 1199187008187 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1199187008188 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1199187008189 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1199187008190 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1199187008191 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1199187008192 homodimer interface [polypeptide binding]; other site 1199187008193 metal binding site [ion binding]; metal-binding site 1199187008194 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1199187008195 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1199187008196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187008197 ATP binding site [chemical binding]; other site 1199187008198 putative Mg++ binding site [ion binding]; other site 1199187008199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187008200 nucleotide binding region [chemical binding]; other site 1199187008201 ATP-binding site [chemical binding]; other site 1199187008202 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1199187008203 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1199187008204 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1199187008205 active site 1199187008206 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1199187008207 substrate binding site [chemical binding]; other site 1199187008208 catalytic residues [active] 1199187008209 dimer interface [polypeptide binding]; other site 1199187008210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008212 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1199187008213 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1199187008214 Substrate binding site; other site 1199187008215 Mg++ binding site; other site 1199187008216 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1199187008217 active site 1199187008218 substrate binding site [chemical binding]; other site 1199187008219 CoA binding site [chemical binding]; other site 1199187008220 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1199187008221 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1199187008222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1199187008223 active site 1199187008224 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1199187008225 ArsC family; Region: ArsC; pfam03960 1199187008226 catalytic residues [active] 1199187008227 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1199187008228 short chain dehydrogenase; Provisional; Region: PRK06197 1199187008229 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1199187008230 putative NAD(P) binding site [chemical binding]; other site 1199187008231 active site 1199187008232 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1199187008233 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1199187008234 5S rRNA interface [nucleotide binding]; other site 1199187008235 CTC domain interface [polypeptide binding]; other site 1199187008236 L16 interface [polypeptide binding]; other site 1199187008237 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1199187008238 putative active site [active] 1199187008239 catalytic residue [active] 1199187008240 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1199187008241 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1199187008242 acyl-activating enzyme (AAE) consensus motif; other site 1199187008243 active site 1199187008244 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1199187008245 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1199187008246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187008247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1199187008248 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1199187008249 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1199187008250 G5 domain; Region: G5; pfam07501 1199187008251 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1199187008252 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1199187008253 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1199187008254 active site 1199187008255 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1199187008256 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1199187008257 active site 1199187008258 HIGH motif; other site 1199187008259 KMSKS motif; other site 1199187008260 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1199187008261 tRNA binding surface [nucleotide binding]; other site 1199187008262 anticodon binding site; other site 1199187008263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1199187008264 PAS domain; Region: PAS_9; pfam13426 1199187008265 putative active site [active] 1199187008266 heme pocket [chemical binding]; other site 1199187008267 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1199187008268 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1199187008269 putative active site [active] 1199187008270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008274 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187008275 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187008276 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187008277 PPE family; Region: PPE; pfam00823 1199187008278 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1199187008279 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1199187008280 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1199187008281 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1199187008282 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1199187008283 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1199187008284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1199187008285 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187008286 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1199187008287 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1199187008288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187008289 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1199187008290 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1199187008291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1199187008292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1199187008293 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1199187008294 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1199187008295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187008296 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1199187008297 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187008298 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187008299 catalytic tetrad [active] 1199187008300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187008301 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1199187008302 Chain length determinant protein; Region: Wzz; pfam02706 1199187008303 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1199187008304 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1199187008305 GAF domain; Region: GAF; cl17456 1199187008306 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1199187008307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1199187008308 metal binding site [ion binding]; metal-binding site 1199187008309 active site 1199187008310 I-site; other site 1199187008311 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1199187008312 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1199187008313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187008314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187008315 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1199187008316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187008317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187008318 DNA binding residues [nucleotide binding] 1199187008319 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187008320 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1199187008321 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1199187008322 Predicted methyltransferases [General function prediction only]; Region: COG0313 1199187008323 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1199187008324 putative SAM binding site [chemical binding]; other site 1199187008325 putative homodimer interface [polypeptide binding]; other site 1199187008326 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1199187008327 arginine deiminase; Provisional; Region: PRK01388 1199187008328 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1199187008329 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1199187008330 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1199187008331 ligand binding site [chemical binding]; other site 1199187008332 flexible hinge region; other site 1199187008333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1199187008334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1199187008335 Coenzyme A binding pocket [chemical binding]; other site 1199187008336 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1199187008337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187008338 active site 1199187008339 motif I; other site 1199187008340 motif II; other site 1199187008341 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1199187008342 active site 1199187008343 dimer interface [polypeptide binding]; other site 1199187008344 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1199187008345 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1199187008346 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1199187008347 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1199187008348 metal binding site [ion binding]; metal-binding site 1199187008349 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187008350 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187008351 [2Fe-2S] cluster binding site [ion binding]; other site 1199187008352 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 1199187008353 putative alpha subunit interface [polypeptide binding]; other site 1199187008354 putative active site [active] 1199187008355 putative substrate binding site [chemical binding]; other site 1199187008356 Fe binding site [ion binding]; other site 1199187008357 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1199187008358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008359 DNA-binding interface [nucleotide binding]; DNA binding site 1199187008360 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187008361 CoenzymeA binding site [chemical binding]; other site 1199187008362 subunit interaction site [polypeptide binding]; other site 1199187008363 PHB binding site; other site 1199187008364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008366 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1199187008367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1199187008368 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1199187008369 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1199187008370 dimer interface [polypeptide binding]; other site 1199187008371 putative functional site; other site 1199187008372 putative MPT binding site; other site 1199187008373 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1199187008374 active site 1199187008375 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1199187008376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1199187008377 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1199187008378 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1199187008379 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1199187008380 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1199187008381 MPT binding site; other site 1199187008382 trimer interface [polypeptide binding]; other site 1199187008383 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1199187008384 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1199187008385 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1199187008386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187008387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187008388 dimerization interface [polypeptide binding]; other site 1199187008389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187008390 dimer interface [polypeptide binding]; other site 1199187008391 phosphorylation site [posttranslational modification] 1199187008392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187008393 ATP binding site [chemical binding]; other site 1199187008394 Mg2+ binding site [ion binding]; other site 1199187008395 G-X-G motif; other site 1199187008396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187008397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187008398 active site 1199187008399 phosphorylation site [posttranslational modification] 1199187008400 intermolecular recognition site; other site 1199187008401 dimerization interface [polypeptide binding]; other site 1199187008402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187008403 DNA binding site [nucleotide binding] 1199187008404 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1199187008405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008406 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187008407 active site 1199187008408 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1199187008409 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1199187008410 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1199187008411 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1199187008412 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1199187008413 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1199187008414 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1199187008415 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1199187008416 carboxyltransferase (CT) interaction site; other site 1199187008417 biotinylation site [posttranslational modification]; other site 1199187008418 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008419 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1199187008420 active site 1199187008421 enoyl-CoA hydratase; Provisional; Region: PRK07827 1199187008422 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187008423 substrate binding site [chemical binding]; other site 1199187008424 oxyanion hole (OAH) forming residues; other site 1199187008425 trimer interface [polypeptide binding]; other site 1199187008426 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1199187008427 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187008428 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187008429 active site 1199187008430 catalytic tetrad [active] 1199187008431 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1199187008432 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1199187008433 metal ion-dependent adhesion site (MIDAS); other site 1199187008434 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1199187008435 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1199187008436 LGFP repeat; Region: LGFP; pfam08310 1199187008437 LGFP repeat; Region: LGFP; pfam08310 1199187008438 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1199187008439 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1199187008440 purine monophosphate binding site [chemical binding]; other site 1199187008441 dimer interface [polypeptide binding]; other site 1199187008442 putative catalytic residues [active] 1199187008443 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1199187008444 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1199187008445 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1199187008446 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1199187008447 active site 1199187008448 cosubstrate binding site; other site 1199187008449 substrate binding site [chemical binding]; other site 1199187008450 catalytic site [active] 1199187008451 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1199187008452 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187008453 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1199187008454 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187008455 active site 1199187008456 Omptin family; Region: Omptin; cl01886 1199187008457 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1199187008458 CoA binding domain; Region: CoA_binding; smart00881 1199187008459 CoA-ligase; Region: Ligase_CoA; pfam00549 1199187008460 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1199187008461 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1199187008462 CoA-ligase; Region: Ligase_CoA; pfam00549 1199187008463 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1199187008464 Peptidase family M23; Region: Peptidase_M23; pfam01551 1199187008465 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1199187008466 Part of AAA domain; Region: AAA_19; pfam13245 1199187008467 Family description; Region: UvrD_C_2; pfam13538 1199187008468 hypothetical protein; Provisional; Region: PRK07857 1199187008469 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1199187008470 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1199187008471 active site 1199187008472 dimer interface [polypeptide binding]; other site 1199187008473 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1199187008474 dimer interface [polypeptide binding]; other site 1199187008475 active site 1199187008476 short chain dehydrogenase; Provisional; Region: PRK08251 1199187008477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187008478 NAD(P) binding site [chemical binding]; other site 1199187008479 active site 1199187008480 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1199187008481 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1199187008482 putative DNA binding site [nucleotide binding]; other site 1199187008483 catalytic residue [active] 1199187008484 putative H2TH interface [polypeptide binding]; other site 1199187008485 putative catalytic residues [active] 1199187008486 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1199187008487 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1199187008488 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1199187008489 active site 1199187008490 SAM binding site [chemical binding]; other site 1199187008491 homodimer interface [polypeptide binding]; other site 1199187008492 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1199187008493 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187008494 anti sigma factor interaction site; other site 1199187008495 regulatory phosphorylation site [posttranslational modification]; other site 1199187008496 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187008497 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187008498 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187008499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187008500 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187008501 substrate binding site [chemical binding]; other site 1199187008502 oxyanion hole (OAH) forming residues; other site 1199187008503 trimer interface [polypeptide binding]; other site 1199187008504 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187008505 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187008506 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1199187008507 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1199187008508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187008509 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1199187008510 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1199187008511 nucleotide binding site [chemical binding]; other site 1199187008512 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1199187008513 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1199187008514 active site 1199187008515 DNA binding site [nucleotide binding] 1199187008516 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1199187008517 DNA binding site [nucleotide binding] 1199187008518 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1199187008519 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1199187008520 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1199187008521 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1199187008522 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1199187008523 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1199187008524 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1199187008525 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1199187008526 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1199187008527 putative substrate binding site [chemical binding]; other site 1199187008528 putative ATP binding site [chemical binding]; other site 1199187008529 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1199187008530 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1199187008531 putative DNA binding site [nucleotide binding]; other site 1199187008532 putative homodimer interface [polypeptide binding]; other site 1199187008533 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1199187008534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187008535 dimer interface [polypeptide binding]; other site 1199187008536 conserved gate region; other site 1199187008537 putative PBP binding loops; other site 1199187008538 ABC-ATPase subunit interface; other site 1199187008539 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1199187008540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187008541 dimer interface [polypeptide binding]; other site 1199187008542 conserved gate region; other site 1199187008543 putative PBP binding loops; other site 1199187008544 ABC-ATPase subunit interface; other site 1199187008545 PBP superfamily domain; Region: PBP_like_2; cl17296 1199187008546 short chain dehydrogenase; Provisional; Region: PRK07814 1199187008547 classical (c) SDRs; Region: SDR_c; cd05233 1199187008548 NAD(P) binding site [chemical binding]; other site 1199187008549 active site 1199187008550 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187008551 manganese transport protein MntH; Reviewed; Region: PRK00701 1199187008552 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1199187008553 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1199187008554 putative active site pocket [active] 1199187008555 dimerization interface [polypeptide binding]; other site 1199187008556 putative catalytic residue [active] 1199187008557 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1199187008558 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1199187008559 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187008560 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1199187008561 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187008562 active site 1199187008563 DNA binding site [nucleotide binding] 1199187008564 Int/Topo IB signature motif; other site 1199187008565 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1199187008566 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1199187008567 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1199187008568 putative active site [active] 1199187008569 putative metal binding site [ion binding]; other site 1199187008570 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1199187008571 KaiC; Region: KaiC; pfam06745 1199187008572 Walker A motif; other site 1199187008573 ATP binding site [chemical binding]; other site 1199187008574 Walker B motif; other site 1199187008575 Helix-turn-helix domain; Region: HTH_28; pfam13518 1199187008576 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187008577 Homeodomain-like domain; Region: HTH_32; pfam13565 1199187008578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187008579 Integrase core domain; Region: rve; pfam00665 1199187008580 Integrase core domain; Region: rve_3; pfam13683 1199187008581 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1199187008582 MULE transposase domain; Region: MULE; pfam10551 1199187008583 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1199187008584 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1199187008585 hydrophobic ligand binding site; other site 1199187008586 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1199187008587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1199187008588 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1199187008589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187008590 motif II; other site 1199187008591 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1199187008592 Beta-lactamase; Region: Beta-lactamase; pfam00144 1199187008593 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1199187008594 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1199187008595 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1199187008596 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187008597 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187008598 substrate binding site [chemical binding]; other site 1199187008599 oxyanion hole (OAH) forming residues; other site 1199187008600 trimer interface [polypeptide binding]; other site 1199187008601 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1199187008602 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1199187008603 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1199187008604 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1199187008605 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1199187008606 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1199187008607 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1199187008608 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1199187008609 putative ADP-binding pocket [chemical binding]; other site 1199187008610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187008611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187008612 active site 1199187008613 phosphorylation site [posttranslational modification] 1199187008614 intermolecular recognition site; other site 1199187008615 dimerization interface [polypeptide binding]; other site 1199187008616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187008617 DNA binding site [nucleotide binding] 1199187008618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187008619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187008620 dimer interface [polypeptide binding]; other site 1199187008621 phosphorylation site [posttranslational modification] 1199187008622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187008623 ATP binding site [chemical binding]; other site 1199187008624 Mg2+ binding site [ion binding]; other site 1199187008625 G-X-G motif; other site 1199187008626 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187008627 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187008628 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1199187008629 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1199187008630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187008631 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1199187008632 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1199187008633 dimer interface [polypeptide binding]; other site 1199187008634 active site 1199187008635 citrylCoA binding site [chemical binding]; other site 1199187008636 NADH binding [chemical binding]; other site 1199187008637 cationic pore residues; other site 1199187008638 oxalacetate/citrate binding site [chemical binding]; other site 1199187008639 coenzyme A binding site [chemical binding]; other site 1199187008640 catalytic triad [active] 1199187008641 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1199187008642 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1199187008643 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1199187008644 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1199187008645 dimer interface [polypeptide binding]; other site 1199187008646 Citrate synthase; Region: Citrate_synt; pfam00285 1199187008647 active site 1199187008648 citrylCoA binding site [chemical binding]; other site 1199187008649 oxalacetate/citrate binding site [chemical binding]; other site 1199187008650 coenzyme A binding site [chemical binding]; other site 1199187008651 catalytic triad [active] 1199187008652 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1199187008653 putative dimer interface [polypeptide binding]; other site 1199187008654 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187008655 Ferredoxin [Energy production and conversion]; Region: COG1146 1199187008656 4Fe-4S binding domain; Region: Fer4; pfam00037 1199187008657 ferredoxin-NADP+ reductase; Region: PLN02852 1199187008658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187008659 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1199187008660 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187008661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187008662 catalytic residue [active] 1199187008663 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1199187008664 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1199187008665 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1199187008666 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1199187008667 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1199187008668 MarR family; Region: MarR; pfam01047 1199187008669 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1199187008670 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1199187008671 hydrophobic ligand binding site; other site 1199187008672 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1199187008673 H+ Antiporter protein; Region: 2A0121; TIGR00900 1199187008674 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1199187008675 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1199187008676 putative active site [active] 1199187008677 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1199187008678 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1199187008679 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1199187008680 putative dimer interface [polypeptide binding]; other site 1199187008681 N-terminal domain interface [polypeptide binding]; other site 1199187008682 putative substrate binding pocket (H-site) [chemical binding]; other site 1199187008683 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187008684 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008685 active site 1199187008686 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1199187008687 DNA-binding site [nucleotide binding]; DNA binding site 1199187008688 RNA-binding motif; other site 1199187008689 hypothetical protein; Provisional; Region: PRK11770 1199187008690 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1199187008691 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1199187008692 Ubiquitin-like proteins; Region: UBQ; cl00155 1199187008693 charged pocket; other site 1199187008694 hydrophobic patch; other site 1199187008695 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1199187008696 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1199187008697 MoaE homodimer interface [polypeptide binding]; other site 1199187008698 MoaD interaction [polypeptide binding]; other site 1199187008699 active site residues [active] 1199187008700 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1199187008701 MPT binding site; other site 1199187008702 trimer interface [polypeptide binding]; other site 1199187008703 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1199187008704 trimer interface [polypeptide binding]; other site 1199187008705 dimer interface [polypeptide binding]; other site 1199187008706 putative active site [active] 1199187008707 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1199187008708 WYL domain; Region: WYL; pfam13280 1199187008709 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1199187008710 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1199187008711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187008712 ATP binding site [chemical binding]; other site 1199187008713 putative Mg++ binding site [ion binding]; other site 1199187008714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187008715 nucleotide binding region [chemical binding]; other site 1199187008716 ATP-binding site [chemical binding]; other site 1199187008717 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1199187008718 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187008719 active site 1199187008720 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1199187008721 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187008722 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1199187008723 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187008724 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1199187008725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008727 hypothetical protein; Provisional; Region: PRK07588 1199187008728 hypothetical protein; Provisional; Region: PRK07236 1199187008729 hypothetical protein; Provisional; Region: PRK07236 1199187008730 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1199187008731 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1199187008732 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1199187008733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187008734 S-adenosylmethionine binding site [chemical binding]; other site 1199187008735 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1199187008736 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187008737 substrate binding site [chemical binding]; other site 1199187008738 oxyanion hole (OAH) forming residues; other site 1199187008739 trimer interface [polypeptide binding]; other site 1199187008740 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1199187008741 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1199187008742 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1199187008743 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187008744 dimer interface [polypeptide binding]; other site 1199187008745 active site 1199187008746 aminotransferase; Validated; Region: PRK07777 1199187008747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187008748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187008749 homodimer interface [polypeptide binding]; other site 1199187008750 catalytic residue [active] 1199187008751 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1199187008752 putative hydrophobic ligand binding site [chemical binding]; other site 1199187008753 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1199187008754 putative hydrophobic ligand binding site [chemical binding]; other site 1199187008755 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187008756 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187008757 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1199187008758 putative hydrophobic ligand binding site [chemical binding]; other site 1199187008759 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1199187008760 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1199187008761 dimer interface [polypeptide binding]; other site 1199187008762 PYR/PP interface [polypeptide binding]; other site 1199187008763 TPP binding site [chemical binding]; other site 1199187008764 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1199187008765 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1199187008766 TPP-binding site [chemical binding]; other site 1199187008767 dimer interface [polypeptide binding]; other site 1199187008768 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1199187008769 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1199187008770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187008771 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1199187008772 acyl-activating enzyme (AAE) consensus motif; other site 1199187008773 acyl-activating enzyme (AAE) consensus motif; other site 1199187008774 putative AMP binding site [chemical binding]; other site 1199187008775 putative active site [active] 1199187008776 putative CoA binding site [chemical binding]; other site 1199187008777 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187008778 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1199187008779 enoyl-CoA hydratase; Provisional; Region: PRK06688 1199187008780 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187008781 substrate binding site [chemical binding]; other site 1199187008782 oxyanion hole (OAH) forming residues; other site 1199187008783 trimer interface [polypeptide binding]; other site 1199187008784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008786 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187008787 Cytochrome P450; Region: p450; cl12078 1199187008788 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 1199187008789 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1199187008790 Subunit I/III interface [polypeptide binding]; other site 1199187008791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008793 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187008794 mce related protein; Region: MCE; pfam02470 1199187008795 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187008796 mce related protein; Region: MCE; pfam02470 1199187008797 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187008798 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187008799 mce related protein; Region: MCE; pfam02470 1199187008800 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187008801 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187008802 mce related protein; Region: MCE; pfam02470 1199187008803 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1199187008804 mce related protein; Region: MCE; pfam02470 1199187008805 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187008806 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187008807 Permease; Region: Permease; pfam02405 1199187008808 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187008809 Permease; Region: Permease; pfam02405 1199187008810 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187008811 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187008812 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1199187008813 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1199187008814 NAD binding site [chemical binding]; other site 1199187008815 catalytic residues [active] 1199187008816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187008817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187008818 NAD(P) binding site [chemical binding]; other site 1199187008819 active site 1199187008820 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1199187008821 Cytochrome P450; Region: p450; cl12078 1199187008822 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187008823 Predicted esterase [General function prediction only]; Region: COG0627 1199187008824 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008825 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187008826 active site 1199187008827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008828 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187008829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187008830 active site 1199187008831 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1199187008832 FMN binding site [chemical binding]; other site 1199187008833 dimer interface [polypeptide binding]; other site 1199187008834 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1199187008835 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1199187008836 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1199187008837 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187008838 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187008839 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1199187008840 iron-sulfur cluster [ion binding]; other site 1199187008841 [2Fe-2S] cluster binding site [ion binding]; other site 1199187008842 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187008843 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1199187008844 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1199187008845 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187008846 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1199187008847 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187008848 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1199187008849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187008850 NAD(P) binding site [chemical binding]; other site 1199187008851 active site 1199187008852 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1199187008853 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187008854 lipid-transfer protein; Provisional; Region: PRK07855 1199187008855 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187008856 active site 1199187008857 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187008858 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1199187008859 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1199187008860 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187008861 Cytochrome P450; Region: p450; cl12078 1199187008862 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1199187008863 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1199187008864 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1199187008865 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1199187008866 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187008867 Cytochrome P450; Region: p450; cl12078 1199187008868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008869 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1199187008870 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187008871 dimer interface [polypeptide binding]; other site 1199187008872 active site 1199187008873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187008875 active site 1199187008876 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187008877 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187008878 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187008879 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187008880 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187008881 [2Fe-2S] cluster binding site [ion binding]; other site 1199187008882 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1199187008883 alpha subunit interface [polypeptide binding]; other site 1199187008884 active site 1199187008885 substrate binding site [chemical binding]; other site 1199187008886 Fe binding site [ion binding]; other site 1199187008887 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1199187008888 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187008889 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1199187008890 active site 1199187008891 SnoaL-like domain; Region: SnoaL_4; pfam13577 1199187008892 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187008893 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008894 active site 1199187008895 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008896 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187008897 active site 1199187008898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008899 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187008900 active site 1199187008901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008903 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187008904 classical (c) SDRs; Region: SDR_c; cd05233 1199187008905 NAD(P) binding site [chemical binding]; other site 1199187008906 active site 1199187008907 short chain dehydrogenase; Provisional; Region: PRK05876 1199187008908 classical (c) SDRs; Region: SDR_c; cd05233 1199187008909 NAD(P) binding site [chemical binding]; other site 1199187008910 active site 1199187008911 classical (c) SDRs; Region: SDR_c; cd05233 1199187008912 NAD(P) binding site [chemical binding]; other site 1199187008913 active site 1199187008914 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187008915 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187008916 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187008917 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187008918 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1199187008919 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1199187008920 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1199187008921 active site 1199187008922 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1199187008923 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1199187008924 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1199187008925 active site 1199187008926 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187008927 Cytochrome P450; Region: p450; cl12078 1199187008928 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187008929 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1199187008930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187008931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187008932 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1199187008933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187008934 NAD(P) binding site [chemical binding]; other site 1199187008935 active site 1199187008936 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1199187008937 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1199187008938 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1199187008939 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1199187008940 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1199187008941 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187008942 TAP-like protein; Region: Abhydrolase_4; pfam08386 1199187008943 Putative cyclase; Region: Cyclase; pfam04199 1199187008944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187008945 NAD(P) binding site [chemical binding]; other site 1199187008946 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 1199187008947 active site 1199187008948 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1199187008949 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1199187008950 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 1199187008951 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1199187008952 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1199187008953 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1199187008954 putative active site [active] 1199187008955 Fe(II) binding site [ion binding]; other site 1199187008956 putative dimer interface [polypeptide binding]; other site 1199187008957 putative tetramer interface [polypeptide binding]; other site 1199187008958 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1199187008959 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1199187008960 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187008961 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187008962 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1199187008963 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1199187008964 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1199187008965 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1199187008966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1199187008967 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1199187008968 ATP binding site [chemical binding]; other site 1199187008969 Mg2+ binding site [ion binding]; other site 1199187008970 G-X-G motif; other site 1199187008971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1199187008972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187008973 active site 1199187008974 phosphorylation site [posttranslational modification] 1199187008975 intermolecular recognition site; other site 1199187008976 dimerization interface [polypeptide binding]; other site 1199187008977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1199187008978 DNA binding residues [nucleotide binding] 1199187008979 dimerization interface [polypeptide binding]; other site 1199187008980 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1199187008981 TPP-binding site [chemical binding]; other site 1199187008982 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1199187008983 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1199187008984 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1199187008985 G4 box; other site 1199187008986 G5 box; other site 1199187008987 putative acyltransferase; Provisional; Region: PRK05790 1199187008988 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187008989 dimer interface [polypeptide binding]; other site 1199187008990 active site 1199187008991 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1199187008992 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1199187008993 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187008994 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187008995 substrate binding site [chemical binding]; other site 1199187008996 oxyanion hole (OAH) forming residues; other site 1199187008997 trimer interface [polypeptide binding]; other site 1199187008998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187008999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009000 active site 1199187009001 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009003 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1199187009004 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187009005 acyl-activating enzyme (AAE) consensus motif; other site 1199187009006 AMP binding site [chemical binding]; other site 1199187009007 active site 1199187009008 CoA binding site [chemical binding]; other site 1199187009009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187009010 catalytic loop [active] 1199187009011 iron binding site [ion binding]; other site 1199187009012 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187009013 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187009014 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187009015 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1199187009016 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187009017 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1199187009018 B12 binding site [chemical binding]; other site 1199187009019 cobalt ligand [ion binding]; other site 1199187009020 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1199187009021 short chain dehydrogenase; Provisional; Region: PRK08278 1199187009022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187009023 NAD(P) binding site [chemical binding]; other site 1199187009024 active site 1199187009025 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1199187009026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187009027 S-adenosylmethionine binding site [chemical binding]; other site 1199187009028 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1199187009029 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1199187009030 DNA-binding site [nucleotide binding]; DNA binding site 1199187009031 RNA-binding motif; other site 1199187009032 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187009033 Cytochrome P450; Region: p450; cl12078 1199187009034 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1199187009035 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1199187009036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187009037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187009038 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187009039 classical (c) SDRs; Region: SDR_c; cd05233 1199187009040 NAD(P) binding site [chemical binding]; other site 1199187009041 active site 1199187009042 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1199187009043 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187009044 DNA-binding interface [nucleotide binding]; DNA binding site 1199187009045 Homeodomain-like domain; Region: HTH_32; pfam13565 1199187009046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187009047 Integrase core domain; Region: rve; pfam00665 1199187009048 Integrase core domain; Region: rve_3; pfam13683 1199187009049 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1199187009050 nucleoside/Zn binding site; other site 1199187009051 dimer interface [polypeptide binding]; other site 1199187009052 catalytic motif [active] 1199187009053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1199187009054 dimerization interface [polypeptide binding]; other site 1199187009055 putative DNA binding site [nucleotide binding]; other site 1199187009056 putative Zn2+ binding site [ion binding]; other site 1199187009057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1199187009058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187009059 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1199187009060 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1199187009061 homodimer interface [polypeptide binding]; other site 1199187009062 putative substrate binding pocket [chemical binding]; other site 1199187009063 diiron center [ion binding]; other site 1199187009064 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1199187009065 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1199187009066 FMN binding site [chemical binding]; other site 1199187009067 active site 1199187009068 catalytic residues [active] 1199187009069 substrate binding site [chemical binding]; other site 1199187009070 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1199187009071 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1199187009072 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1199187009073 PhoU domain; Region: PhoU; pfam01895 1199187009074 PhoU domain; Region: PhoU; pfam01895 1199187009075 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1199187009076 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1199187009077 Walker A/P-loop; other site 1199187009078 ATP binding site [chemical binding]; other site 1199187009079 Q-loop/lid; other site 1199187009080 ABC transporter signature motif; other site 1199187009081 Walker B; other site 1199187009082 D-loop; other site 1199187009083 H-loop/switch region; other site 1199187009084 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1199187009085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187009086 dimer interface [polypeptide binding]; other site 1199187009087 conserved gate region; other site 1199187009088 putative PBP binding loops; other site 1199187009089 ABC-ATPase subunit interface; other site 1199187009090 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1199187009091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187009092 dimer interface [polypeptide binding]; other site 1199187009093 conserved gate region; other site 1199187009094 putative PBP binding loops; other site 1199187009095 ABC-ATPase subunit interface; other site 1199187009096 PBP superfamily domain; Region: PBP_like_2; cl17296 1199187009097 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1199187009098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1199187009099 Coenzyme A binding pocket [chemical binding]; other site 1199187009100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187009101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187009102 DNA binding site [nucleotide binding] 1199187009103 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1199187009104 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1199187009105 catalytic residues [active] 1199187009106 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1199187009107 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1199187009108 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1199187009109 active site residue [active] 1199187009110 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1199187009111 active site residue [active] 1199187009112 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1199187009113 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1199187009114 heme-binding site [chemical binding]; other site 1199187009115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1199187009116 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1199187009117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187009118 catalytic residue [active] 1199187009119 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1199187009120 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1199187009121 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1199187009122 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1199187009123 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1199187009124 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1199187009125 dimerization interface [polypeptide binding]; other site 1199187009126 putative ATP binding site [chemical binding]; other site 1199187009127 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1199187009128 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1199187009129 active site 1199187009130 tetramer interface [polypeptide binding]; other site 1199187009131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1199187009132 active site 1199187009133 CAAX protease self-immunity; Region: Abi; pfam02517 1199187009134 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1199187009135 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1199187009136 dimerization interface [polypeptide binding]; other site 1199187009137 ATP binding site [chemical binding]; other site 1199187009138 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1199187009139 dimerization interface [polypeptide binding]; other site 1199187009140 ATP binding site [chemical binding]; other site 1199187009141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1199187009142 active site 1199187009143 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187009144 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1199187009145 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1199187009146 active site 1199187009147 metal binding site [ion binding]; metal-binding site 1199187009148 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1199187009149 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 1199187009150 Cupin domain; Region: Cupin_2; cl17218 1199187009151 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1199187009152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187009153 DNA-binding site [nucleotide binding]; DNA binding site 1199187009154 UTRA domain; Region: UTRA; pfam07702 1199187009155 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1199187009156 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1199187009157 putative active site [active] 1199187009158 catalytic triad [active] 1199187009159 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1199187009160 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1199187009161 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1199187009162 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1199187009163 FAD binding domain; Region: FAD_binding_2; pfam00890 1199187009164 Predicted deacetylase [General function prediction only]; Region: COG3233 1199187009165 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1199187009166 putative active site [active] 1199187009167 putative Zn binding site [ion binding]; other site 1199187009168 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1199187009169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187009170 putative substrate translocation pore; other site 1199187009171 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1199187009172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187009173 putative substrate translocation pore; other site 1199187009174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187009175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187009176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187009177 WHG domain; Region: WHG; pfam13305 1199187009178 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1199187009179 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187009180 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1199187009181 ATP binding site [chemical binding]; other site 1199187009182 active site 1199187009183 substrate binding site [chemical binding]; other site 1199187009184 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187009185 Cytochrome P450; Region: p450; cl12078 1199187009186 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1199187009187 adenylosuccinate lyase; Region: purB; TIGR00928 1199187009188 tetramer interface [polypeptide binding]; other site 1199187009189 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1199187009190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1199187009191 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1199187009192 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1199187009193 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1199187009194 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1199187009195 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1199187009196 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1199187009197 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1199187009198 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1199187009199 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1199187009200 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1199187009201 short chain dehydrogenase; Provisional; Region: PRK07774 1199187009202 classical (c) SDRs; Region: SDR_c; cd05233 1199187009203 NAD(P) binding site [chemical binding]; other site 1199187009204 active site 1199187009205 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1199187009206 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1199187009207 NAD binding site [chemical binding]; other site 1199187009208 catalytic residues [active] 1199187009209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187009210 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187009211 Cytochrome P450; Region: p450; cl12078 1199187009212 short chain dehydrogenase; Provisional; Region: PRK07775 1199187009213 classical (c) SDRs; Region: SDR_c; cd05233 1199187009214 NAD(P) binding site [chemical binding]; other site 1199187009215 active site 1199187009216 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187009217 Cytochrome P450; Region: p450; cl12078 1199187009218 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1199187009219 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1199187009220 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1199187009221 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1199187009222 NAD binding site [chemical binding]; other site 1199187009223 catalytic Zn binding site [ion binding]; other site 1199187009224 substrate binding site [chemical binding]; other site 1199187009225 structural Zn binding site [ion binding]; other site 1199187009226 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1199187009227 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1199187009228 nucleotide binding site/active site [active] 1199187009229 HIT family signature motif; other site 1199187009230 catalytic residue [active] 1199187009231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187009232 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187009233 dimerization interface [polypeptide binding]; other site 1199187009234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187009235 dimer interface [polypeptide binding]; other site 1199187009236 phosphorylation site [posttranslational modification] 1199187009237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187009238 ATP binding site [chemical binding]; other site 1199187009239 Mg2+ binding site [ion binding]; other site 1199187009240 G-X-G motif; other site 1199187009241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187009242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187009243 active site 1199187009244 phosphorylation site [posttranslational modification] 1199187009245 intermolecular recognition site; other site 1199187009246 dimerization interface [polypeptide binding]; other site 1199187009247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187009248 DNA binding site [nucleotide binding] 1199187009249 Helix-turn-helix domain; Region: HTH_28; pfam13518 1199187009250 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187009251 Homeodomain-like domain; Region: HTH_32; pfam13565 1199187009252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187009253 Integrase core domain; Region: rve; pfam00665 1199187009254 Integrase core domain; Region: rve_3; pfam13683 1199187009255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1199187009256 binding surface 1199187009257 TPR motif; other site 1199187009258 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187009259 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1199187009260 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1199187009261 catalytic residue [active] 1199187009262 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1199187009263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187009264 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1199187009265 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1199187009266 Amidase; Region: Amidase; pfam01425 1199187009267 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1199187009268 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1199187009269 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187009270 classical (c) SDRs; Region: SDR_c; cd05233 1199187009271 NAD(P) binding site [chemical binding]; other site 1199187009272 active site 1199187009273 short chain dehydrogenase; Provisional; Region: PRK05875 1199187009274 classical (c) SDRs; Region: SDR_c; cd05233 1199187009275 NAD(P) binding site [chemical binding]; other site 1199187009276 active site 1199187009277 enoyl-CoA hydratase; Provisional; Region: PRK08290 1199187009278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187009279 substrate binding site [chemical binding]; other site 1199187009280 oxyanion hole (OAH) forming residues; other site 1199187009281 trimer interface [polypeptide binding]; other site 1199187009282 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1199187009283 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1199187009284 AAA domain; Region: AAA_23; pfam13476 1199187009285 Walker A/P-loop; other site 1199187009286 ATP binding site [chemical binding]; other site 1199187009287 ABC transporter; Region: ABC_tran; pfam00005 1199187009288 Q-loop/lid; other site 1199187009289 ABC transporter signature motif; other site 1199187009290 Walker B; other site 1199187009291 D-loop; other site 1199187009292 H-loop/switch region; other site 1199187009293 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1199187009294 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1199187009295 active site 1199187009296 homotetramer interface [polypeptide binding]; other site 1199187009297 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187009298 mce related protein; Region: MCE; pfam02470 1199187009299 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187009300 mce related protein; Region: MCE; pfam02470 1199187009301 mce related protein; Region: MCE; pfam02470 1199187009302 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187009303 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187009304 mce related protein; Region: MCE; pfam02470 1199187009305 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1199187009306 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187009307 mce related protein; Region: MCE; pfam02470 1199187009308 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187009309 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187009310 mce related protein; Region: MCE; pfam02470 1199187009311 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187009312 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187009313 Permease; Region: Permease; pfam02405 1199187009314 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187009315 Permease; Region: Permease; pfam02405 1199187009316 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1199187009317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187009318 NAD(P) binding site [chemical binding]; other site 1199187009319 active site 1199187009320 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1199187009321 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1199187009322 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009323 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1199187009324 FAD binding site [chemical binding]; other site 1199187009325 substrate binding site [chemical binding]; other site 1199187009326 catalytic base [active] 1199187009327 acyl-CoA synthetase; Validated; Region: PRK07867 1199187009328 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1199187009329 acyl-activating enzyme (AAE) consensus motif; other site 1199187009330 putative AMP binding site [chemical binding]; other site 1199187009331 putative active site [active] 1199187009332 putative CoA binding site [chemical binding]; other site 1199187009333 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1199187009334 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1199187009335 acyl-CoA synthetase; Validated; Region: PRK07798 1199187009336 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187009337 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1199187009338 acyl-activating enzyme (AAE) consensus motif; other site 1199187009339 acyl-activating enzyme (AAE) consensus motif; other site 1199187009340 putative AMP binding site [chemical binding]; other site 1199187009341 putative active site [active] 1199187009342 putative CoA binding site [chemical binding]; other site 1199187009343 enoyl-CoA hydratase; Provisional; Region: PRK07799 1199187009344 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187009345 substrate binding site [chemical binding]; other site 1199187009346 oxyanion hole (OAH) forming residues; other site 1199187009347 trimer interface [polypeptide binding]; other site 1199187009348 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1199187009349 putative active site [active] 1199187009350 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187009351 Cytochrome P450; Region: p450; cl12078 1199187009352 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1199187009353 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187009354 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1199187009355 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1199187009356 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187009357 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1199187009358 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187009359 lipid-transfer protein; Provisional; Region: PRK07937 1199187009360 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187009361 active site 1199187009362 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1199187009363 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187009364 active site 1199187009365 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1199187009366 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1199187009367 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1199187009368 trimer interface [polypeptide binding]; other site 1199187009369 putative metal binding site [ion binding]; other site 1199187009370 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187009371 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1199187009372 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1199187009373 short chain dehydrogenase; Provisional; Region: PRK07890 1199187009374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187009375 NAD(P) binding site [chemical binding]; other site 1199187009376 active site 1199187009377 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1199187009378 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1199187009379 active site 1199187009380 catalytic residues [active] 1199187009381 metal binding site [ion binding]; metal-binding site 1199187009382 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1199187009383 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1199187009384 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1199187009385 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1199187009386 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1199187009387 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1199187009388 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1199187009389 enoyl-CoA hydratase; Region: PLN02864 1199187009390 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1199187009391 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1199187009392 dimer interaction site [polypeptide binding]; other site 1199187009393 substrate-binding tunnel; other site 1199187009394 active site 1199187009395 catalytic site [active] 1199187009396 substrate binding site [chemical binding]; other site 1199187009397 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1199187009398 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1199187009399 putative active site [active] 1199187009400 lipid-transfer protein; Provisional; Region: PRK07855 1199187009401 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187009402 active site 1199187009403 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1199187009404 putative active site [active] 1199187009405 putative catalytic site [active] 1199187009406 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1199187009407 active site 1199187009408 catalytic site [active] 1199187009409 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1199187009410 active site 2 [active] 1199187009411 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1199187009412 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187009413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009415 active site 1199187009416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009417 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187009418 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009419 active site 1199187009420 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187009421 Cytochrome P450; Region: p450; cl12078 1199187009422 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1199187009423 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187009424 dimer interface [polypeptide binding]; other site 1199187009425 active site 1199187009426 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1199187009427 short chain dehydrogenase; Provisional; Region: PRK07791 1199187009428 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1199187009429 homodimer interface [polypeptide binding]; other site 1199187009430 NAD binding site [chemical binding]; other site 1199187009431 active site 1199187009432 short chain dehydrogenase; Provisional; Region: PRK07856 1199187009433 classical (c) SDRs; Region: SDR_c; cd05233 1199187009434 NAD(P) binding site [chemical binding]; other site 1199187009435 active site 1199187009436 enoyl-CoA hydratase; Provisional; Region: PRK06495 1199187009437 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187009438 substrate binding site [chemical binding]; other site 1199187009439 oxyanion hole (OAH) forming residues; other site 1199187009440 trimer interface [polypeptide binding]; other site 1199187009441 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1199187009442 Coenzyme A transferase; Region: CoA_trans; cl17247 1199187009443 Nitronate monooxygenase; Region: NMO; pfam03060 1199187009444 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1199187009445 FMN binding site [chemical binding]; other site 1199187009446 substrate binding site [chemical binding]; other site 1199187009447 putative catalytic residue [active] 1199187009448 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1199187009449 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1199187009450 dimer interface [polypeptide binding]; other site 1199187009451 active site 1199187009452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187009453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187009454 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1199187009455 short chain dehydrogenase; Provisional; Region: PRK07831 1199187009456 classical (c) SDRs; Region: SDR_c; cd05233 1199187009457 NAD(P) binding site [chemical binding]; other site 1199187009458 active site 1199187009459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009461 active site 1199187009462 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187009463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187009464 acyl-activating enzyme (AAE) consensus motif; other site 1199187009465 acyl-activating enzyme (AAE) consensus motif; other site 1199187009466 active site 1199187009467 AMP binding site [chemical binding]; other site 1199187009468 CoA binding site [chemical binding]; other site 1199187009469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009470 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009471 active site 1199187009472 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187009473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009475 active site 1199187009476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009477 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187009478 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009479 aspartate aminotransferase; Provisional; Region: PRK05764 1199187009480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187009481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187009482 homodimer interface [polypeptide binding]; other site 1199187009483 catalytic residue [active] 1199187009484 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1199187009485 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1199187009486 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1199187009487 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1199187009488 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1199187009489 active site 1199187009490 Fe binding site [ion binding]; other site 1199187009491 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1199187009492 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009493 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1199187009494 Flavin binding site [chemical binding]; other site 1199187009495 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1199187009496 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1199187009497 FAD binding pocket [chemical binding]; other site 1199187009498 FAD binding motif [chemical binding]; other site 1199187009499 phosphate binding motif [ion binding]; other site 1199187009500 beta-alpha-beta structure motif; other site 1199187009501 NAD(p) ribose binding residues [chemical binding]; other site 1199187009502 NAD binding pocket [chemical binding]; other site 1199187009503 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1199187009504 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1199187009505 catalytic loop [active] 1199187009506 iron binding site [ion binding]; other site 1199187009507 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1199187009508 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1199187009509 putative NAD(P) binding site [chemical binding]; other site 1199187009510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187009511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009512 active site 1199187009513 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187009514 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187009515 active site 1199187009516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187009517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187009518 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1199187009519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1199187009520 DNA binding site [nucleotide binding] 1199187009521 domain linker motif; other site 1199187009522 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1199187009523 putative dimerization interface [polypeptide binding]; other site 1199187009524 putative ligand binding site [chemical binding]; other site 1199187009525 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1199187009526 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1199187009527 intersubunit interface [polypeptide binding]; other site 1199187009528 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1199187009529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187009530 Walker A/P-loop; other site 1199187009531 ATP binding site [chemical binding]; other site 1199187009532 Q-loop/lid; other site 1199187009533 ABC transporter signature motif; other site 1199187009534 Walker B; other site 1199187009535 D-loop; other site 1199187009536 H-loop/switch region; other site 1199187009537 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1199187009538 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1199187009539 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1199187009540 putative active site [active] 1199187009541 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1199187009542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1199187009543 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1199187009544 transmembrane helices; other site 1199187009545 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1199187009546 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1199187009547 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1199187009548 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1199187009549 active site 1199187009550 catalytic site [active] 1199187009551 metal binding site [ion binding]; metal-binding site 1199187009552 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1199187009553 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1199187009554 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1199187009555 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1199187009556 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187009557 active site 1199187009558 HIGH motif; other site 1199187009559 nucleotide binding site [chemical binding]; other site 1199187009560 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1199187009561 KMSKS motif; other site 1199187009562 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1199187009563 tRNA binding surface [nucleotide binding]; other site 1199187009564 anticodon binding site; other site 1199187009565 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1199187009566 homotrimer interaction site [polypeptide binding]; other site 1199187009567 zinc binding site [ion binding]; other site 1199187009568 CDP-binding sites; other site 1199187009569 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1199187009570 substrate binding site; other site 1199187009571 dimer interface; other site 1199187009572 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1199187009573 DNA repair protein RadA; Provisional; Region: PRK11823 1199187009574 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1199187009575 Walker A motif; other site 1199187009576 ATP binding site [chemical binding]; other site 1199187009577 Walker B motif; other site 1199187009578 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1199187009579 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1199187009580 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1199187009581 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1199187009582 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1199187009583 active site clefts [active] 1199187009584 zinc binding site [ion binding]; other site 1199187009585 dimer interface [polypeptide binding]; other site 1199187009586 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1199187009587 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1199187009588 minor groove reading motif; other site 1199187009589 helix-hairpin-helix signature motif; other site 1199187009590 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1199187009591 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187009592 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1199187009593 catalytic site [active] 1199187009594 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1199187009595 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1199187009596 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1199187009597 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1199187009598 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1199187009599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187009600 catalytic core [active] 1199187009601 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1199187009602 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1199187009603 Clp amino terminal domain; Region: Clp_N; pfam02861 1199187009604 Clp amino terminal domain; Region: Clp_N; pfam02861 1199187009605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187009606 Walker A motif; other site 1199187009607 ATP binding site [chemical binding]; other site 1199187009608 Walker B motif; other site 1199187009609 arginine finger; other site 1199187009610 UvrB/uvrC motif; Region: UVR; pfam02151 1199187009611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187009612 Walker A motif; other site 1199187009613 ATP binding site [chemical binding]; other site 1199187009614 Walker B motif; other site 1199187009615 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1199187009616 Lsr2; Region: Lsr2; pfam11774 1199187009617 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1199187009618 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1199187009619 dimer interface [polypeptide binding]; other site 1199187009620 putative anticodon binding site; other site 1199187009621 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1199187009622 motif 1; other site 1199187009623 dimer interface [polypeptide binding]; other site 1199187009624 active site 1199187009625 motif 2; other site 1199187009626 motif 3; other site 1199187009627 pantothenate kinase; Reviewed; Region: PRK13318 1199187009628 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1199187009629 tetramerization interface [polypeptide binding]; other site 1199187009630 active site 1199187009631 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1199187009632 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1199187009633 active site 1199187009634 ATP-binding site [chemical binding]; other site 1199187009635 pantoate-binding site; other site 1199187009636 HXXH motif; other site 1199187009637 Rossmann-like domain; Region: Rossmann-like; pfam10727 1199187009638 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1199187009639 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1199187009640 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1199187009641 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1199187009642 catalytic center binding site [active] 1199187009643 ATP binding site [chemical binding]; other site 1199187009644 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1199187009645 homooctamer interface [polypeptide binding]; other site 1199187009646 active site 1199187009647 dihydropteroate synthase; Region: DHPS; TIGR01496 1199187009648 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1199187009649 substrate binding pocket [chemical binding]; other site 1199187009650 dimer interface [polypeptide binding]; other site 1199187009651 inhibitor binding site; inhibition site 1199187009652 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1199187009653 homodecamer interface [polypeptide binding]; other site 1199187009654 GTP cyclohydrolase I; Provisional; Region: PLN03044 1199187009655 active site 1199187009656 putative catalytic site residues [active] 1199187009657 zinc binding site [ion binding]; other site 1199187009658 GTP-CH-I/GFRP interaction surface; other site 1199187009659 FtsH Extracellular; Region: FtsH_ext; pfam06480 1199187009660 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1199187009661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187009662 Walker A motif; other site 1199187009663 ATP binding site [chemical binding]; other site 1199187009664 Walker B motif; other site 1199187009665 arginine finger; other site 1199187009666 Peptidase family M41; Region: Peptidase_M41; pfam01434 1199187009667 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1199187009668 dimer interface [polypeptide binding]; other site 1199187009669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187009670 metal binding site [ion binding]; metal-binding site 1199187009671 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187009672 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187009673 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187009674 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1199187009675 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1199187009676 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1199187009677 putative NAD(P) binding site [chemical binding]; other site 1199187009678 catalytic Zn binding site [ion binding]; other site 1199187009679 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187009680 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187009681 active site 1199187009682 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187009683 PPE family; Region: PPE; pfam00823 1199187009684 PE family; Region: PE; pfam00934 1199187009685 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1199187009686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1199187009687 active site 1199187009688 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1199187009689 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1199187009690 Ligand Binding Site [chemical binding]; other site 1199187009691 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1199187009692 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1199187009693 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1199187009694 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1199187009695 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1199187009696 dimer interface [polypeptide binding]; other site 1199187009697 substrate binding site [chemical binding]; other site 1199187009698 metal binding sites [ion binding]; metal-binding site 1199187009699 Protein of unknown function (DUF475); Region: DUF475; pfam04332 1199187009700 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1199187009701 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1199187009702 Ligand binding site; other site 1199187009703 Putative Catalytic site; other site 1199187009704 DXD motif; other site 1199187009705 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1199187009706 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1199187009707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187009708 NAD(P) binding site [chemical binding]; other site 1199187009709 active site 1199187009710 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1199187009711 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1199187009712 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1199187009713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187009714 dimerization interface [polypeptide binding]; other site 1199187009715 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1199187009716 cyclase homology domain; Region: CHD; cd07302 1199187009717 nucleotidyl binding site; other site 1199187009718 metal binding site [ion binding]; metal-binding site 1199187009719 dimer interface [polypeptide binding]; other site 1199187009720 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1199187009721 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1199187009722 active site 1199187009723 interdomain interaction site; other site 1199187009724 putative metal-binding site [ion binding]; other site 1199187009725 nucleotide binding site [chemical binding]; other site 1199187009726 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1199187009727 domain I; other site 1199187009728 phosphate binding site [ion binding]; other site 1199187009729 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1199187009730 domain II; other site 1199187009731 domain III; other site 1199187009732 nucleotide binding site [chemical binding]; other site 1199187009733 DNA binding groove [nucleotide binding] 1199187009734 catalytic site [active] 1199187009735 domain IV; other site 1199187009736 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1199187009737 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1199187009738 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1199187009739 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1199187009740 DNA-binding site [nucleotide binding]; DNA binding site 1199187009741 RNA-binding motif; other site 1199187009742 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1199187009743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1199187009744 ATP binding site [chemical binding]; other site 1199187009745 putative Mg++ binding site [ion binding]; other site 1199187009746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1199187009747 nucleotide binding region [chemical binding]; other site 1199187009748 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1199187009749 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1199187009750 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1199187009751 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1199187009752 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1199187009753 hexamer interface [polypeptide binding]; other site 1199187009754 Walker B motif; other site 1199187009755 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1199187009756 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1199187009757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187009758 motif II; other site 1199187009759 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1199187009760 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1199187009761 Walker A/P-loop; other site 1199187009762 ATP binding site [chemical binding]; other site 1199187009763 Q-loop/lid; other site 1199187009764 ABC transporter signature motif; other site 1199187009765 Walker B; other site 1199187009766 D-loop; other site 1199187009767 H-loop/switch region; other site 1199187009768 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1199187009769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1199187009770 Walker A/P-loop; other site 1199187009771 ATP binding site [chemical binding]; other site 1199187009772 Q-loop/lid; other site 1199187009773 ABC transporter signature motif; other site 1199187009774 Walker B; other site 1199187009775 D-loop; other site 1199187009776 H-loop/switch region; other site 1199187009777 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1199187009778 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1199187009779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187009780 dimer interface [polypeptide binding]; other site 1199187009781 conserved gate region; other site 1199187009782 putative PBP binding loops; other site 1199187009783 ABC-ATPase subunit interface; other site 1199187009784 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1199187009785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187009786 dimer interface [polypeptide binding]; other site 1199187009787 conserved gate region; other site 1199187009788 ABC-ATPase subunit interface; other site 1199187009789 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1199187009790 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1199187009791 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1199187009792 acetyl-CoA synthetase; Provisional; Region: PRK00174 1199187009793 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1199187009794 active site 1199187009795 CoA binding site [chemical binding]; other site 1199187009796 acyl-activating enzyme (AAE) consensus motif; other site 1199187009797 AMP binding site [chemical binding]; other site 1199187009798 acetate binding site [chemical binding]; other site 1199187009799 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1199187009800 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1199187009801 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187009802 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1199187009803 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1199187009804 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1199187009805 putative active site [active] 1199187009806 putative CoA binding site [chemical binding]; other site 1199187009807 nudix motif; other site 1199187009808 metal binding site [ion binding]; metal-binding site 1199187009809 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1199187009810 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1199187009811 catalytic residues [active] 1199187009812 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1199187009813 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1199187009814 minor groove reading motif; other site 1199187009815 helix-hairpin-helix signature motif; other site 1199187009816 substrate binding pocket [chemical binding]; other site 1199187009817 active site 1199187009818 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1199187009819 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1199187009820 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1199187009821 ligand binding site [chemical binding]; other site 1199187009822 flexible hinge region; other site 1199187009823 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1199187009824 putative switch regulator; other site 1199187009825 non-specific DNA interactions [nucleotide binding]; other site 1199187009826 DNA binding site [nucleotide binding] 1199187009827 sequence specific DNA binding site [nucleotide binding]; other site 1199187009828 putative cAMP binding site [chemical binding]; other site 1199187009829 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187009830 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1199187009831 homotrimer interaction site [polypeptide binding]; other site 1199187009832 putative active site [active] 1199187009833 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1199187009834 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1199187009835 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1199187009836 P loop; other site 1199187009837 Nucleotide binding site [chemical binding]; other site 1199187009838 DTAP/Switch II; other site 1199187009839 Switch I; other site 1199187009840 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1199187009841 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1199187009842 DTAP/Switch II; other site 1199187009843 Switch I; other site 1199187009844 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1199187009845 Transcription factor WhiB; Region: Whib; pfam02467 1199187009846 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1199187009847 Transglycosylase; Region: Transgly; pfam00912 1199187009848 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1199187009849 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1199187009850 phosphodiesterase YaeI; Provisional; Region: PRK11340 1199187009851 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1199187009852 putative active site [active] 1199187009853 putative metal binding site [ion binding]; other site 1199187009854 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1199187009855 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1199187009856 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187009857 catalytic residue [active] 1199187009858 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1199187009859 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1199187009860 GAF domain; Region: GAF; pfam01590 1199187009861 ANTAR domain; Region: ANTAR; pfam03861 1199187009862 Restriction endonuclease; Region: Mrr_cat; pfam04471 1199187009863 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1199187009864 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1199187009865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187009866 motif II; other site 1199187009867 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187009868 anti sigma factor interaction site; other site 1199187009869 regulatory phosphorylation site [posttranslational modification]; other site 1199187009870 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1199187009871 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1199187009872 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1199187009873 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1199187009874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187009875 ATP binding site [chemical binding]; other site 1199187009876 G-X-G motif; other site 1199187009877 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1199187009878 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1199187009879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1199187009880 PAS domain; Region: PAS_9; pfam13426 1199187009881 putative active site [active] 1199187009882 heme pocket [chemical binding]; other site 1199187009883 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1199187009884 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1199187009885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1199187009886 putative methyltransferase; Provisional; Region: PRK14967 1199187009887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187009888 S-adenosylmethionine binding site [chemical binding]; other site 1199187009889 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1199187009890 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1199187009891 proposed catalytic triad [active] 1199187009892 conserved cys residue [active] 1199187009893 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1199187009894 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187009895 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1199187009896 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187009897 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187009898 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187009899 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1199187009900 molybdopterin cofactor binding site; other site 1199187009901 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1199187009902 selenophosphate synthetase; Provisional; Region: PRK00943 1199187009903 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1199187009904 dimerization interface [polypeptide binding]; other site 1199187009905 putative ATP binding site [chemical binding]; other site 1199187009906 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1199187009907 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187009908 selenocysteine synthase; Provisional; Region: PRK04311 1199187009909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187009910 catalytic residue [active] 1199187009911 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1199187009912 G1 box; other site 1199187009913 putative GEF interaction site [polypeptide binding]; other site 1199187009914 GTP/Mg2+ binding site [chemical binding]; other site 1199187009915 Switch I region; other site 1199187009916 G2 box; other site 1199187009917 G3 box; other site 1199187009918 Switch II region; other site 1199187009919 G4 box; other site 1199187009920 G5 box; other site 1199187009921 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1199187009922 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1199187009923 Yqey-like protein; Region: YqeY; pfam09424 1199187009924 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 1199187009925 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1199187009926 MoxR-like ATPases [General function prediction only]; Region: COG0714 1199187009927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1199187009928 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1199187009929 Protein of unknown function DUF58; Region: DUF58; pfam01882 1199187009930 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1199187009931 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1199187009932 Predicted transcriptional regulators [Transcription]; Region: COG1695 1199187009933 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1199187009934 glycerol kinase; Provisional; Region: glpK; PRK00047 1199187009935 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1199187009936 nucleotide binding site [chemical binding]; other site 1199187009937 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1199187009938 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1199187009939 NAD binding site [chemical binding]; other site 1199187009940 dimerization interface [polypeptide binding]; other site 1199187009941 ligand binding site [chemical binding]; other site 1199187009942 catalytic site [active] 1199187009943 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1199187009944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187009945 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187009946 classical (c) SDRs; Region: SDR_c; cd05233 1199187009947 NAD(P) binding site [chemical binding]; other site 1199187009948 active site 1199187009949 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187009950 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1199187009951 short chain dehydrogenase; Provisional; Region: PRK07856 1199187009952 classical (c) SDRs; Region: SDR_c; cd05233 1199187009953 NAD(P) binding site [chemical binding]; other site 1199187009954 active site 1199187009955 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187009956 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1199187009957 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 1199187009958 nudix motif; other site 1199187009959 haloalkane dehalogenase; Provisional; Region: PRK00870 1199187009960 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187009961 Cytochrome P450; Region: p450; cl12078 1199187009962 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1199187009963 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1199187009964 active site 1199187009965 DNA binding site [nucleotide binding] 1199187009966 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1199187009967 DNA binding site [nucleotide binding] 1199187009968 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1199187009969 nucleotide binding site [chemical binding]; other site 1199187009970 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1199187009971 Transposase domain (DUF772); Region: DUF772; pfam05598 1199187009972 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187009973 Cytochrome P450; Region: p450; cl12078 1199187009974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187009975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187009976 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1199187009977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187009978 NAD(P) binding site [chemical binding]; other site 1199187009979 active site 1199187009980 Cutinase; Region: Cutinase; pfam01083 1199187009981 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1199187009982 CHAT domain; Region: CHAT; cl17868 1199187009983 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1199187009984 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1199187009985 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187009986 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187009987 catalytic residue [active] 1199187009988 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1199187009989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187009990 Walker A motif; other site 1199187009991 ATP binding site [chemical binding]; other site 1199187009992 Walker B motif; other site 1199187009993 arginine finger; other site 1199187009994 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1199187009995 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1199187009996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187009997 S-adenosylmethionine binding site [chemical binding]; other site 1199187009998 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1199187009999 FAD binding domain; Region: FAD_binding_4; pfam01565 1199187010000 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1199187010001 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1199187010002 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1199187010003 active site 1199187010004 metal binding site [ion binding]; metal-binding site 1199187010005 hypothetical protein; Validated; Region: PRK00153 1199187010006 recombination protein RecR; Reviewed; Region: recR; PRK00076 1199187010007 RecR protein; Region: RecR; pfam02132 1199187010008 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1199187010009 putative active site [active] 1199187010010 putative metal-binding site [ion binding]; other site 1199187010011 tetramer interface [polypeptide binding]; other site 1199187010012 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1199187010013 catalytic triad [active] 1199187010014 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1199187010015 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1199187010016 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1199187010017 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1199187010018 active site 1199187010019 catalytic site [active] 1199187010020 substrate binding site [chemical binding]; other site 1199187010021 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1199187010022 Dimer interface [polypeptide binding]; other site 1199187010023 BRCT sequence motif; other site 1199187010024 2-isopropylmalate synthase; Validated; Region: PRK03739 1199187010025 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1199187010026 active site 1199187010027 catalytic residues [active] 1199187010028 metal binding site [ion binding]; metal-binding site 1199187010029 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1199187010030 aspartate kinase; Reviewed; Region: PRK06635 1199187010031 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1199187010032 putative nucleotide binding site [chemical binding]; other site 1199187010033 putative catalytic residues [active] 1199187010034 putative Mg ion binding site [ion binding]; other site 1199187010035 putative aspartate binding site [chemical binding]; other site 1199187010036 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1199187010037 putative allosteric regulatory site; other site 1199187010038 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1199187010039 putative allosteric regulatory residue; other site 1199187010040 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1199187010041 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1199187010042 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1199187010043 PknH-like extracellular domain; Region: PknH_C; pfam14032 1199187010044 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 1199187010045 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1199187010046 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1199187010047 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1199187010048 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1199187010049 putative active site [active] 1199187010050 putative dimer interface [polypeptide binding]; other site 1199187010051 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1199187010052 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1199187010053 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187010054 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1199187010055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187010056 catalytic residue [active] 1199187010057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187010058 S-adenosylmethionine binding site [chemical binding]; other site 1199187010059 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1199187010060 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1199187010061 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1199187010062 substrate binding site [chemical binding]; other site 1199187010063 dimer interface [polypeptide binding]; other site 1199187010064 ATP binding site [chemical binding]; other site 1199187010065 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1199187010066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187010067 non-specific DNA binding site [nucleotide binding]; other site 1199187010068 salt bridge; other site 1199187010069 sequence-specific DNA binding site [nucleotide binding]; other site 1199187010070 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1199187010071 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1199187010072 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1199187010073 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1199187010074 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1199187010075 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1199187010076 tetramer interface [polypeptide binding]; other site 1199187010077 active site 1199187010078 Mg2+/Mn2+ binding site [ion binding]; other site 1199187010079 citrate synthase; Provisional; Region: PRK14033 1199187010080 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1199187010081 dimer interface [polypeptide binding]; other site 1199187010082 active site 1199187010083 citrylCoA binding site [chemical binding]; other site 1199187010084 oxalacetate/citrate binding site [chemical binding]; other site 1199187010085 coenzyme A binding site [chemical binding]; other site 1199187010086 catalytic triad [active] 1199187010087 pyruvate carboxylase; Reviewed; Region: PRK12999 1199187010088 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1199187010089 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1199187010090 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1199187010091 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1199187010092 active site 1199187010093 catalytic residues [active] 1199187010094 metal binding site [ion binding]; metal-binding site 1199187010095 homodimer binding site [polypeptide binding]; other site 1199187010096 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1199187010097 carboxyltransferase (CT) interaction site; other site 1199187010098 biotinylation site [posttranslational modification]; other site 1199187010099 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1199187010100 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187010101 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187010102 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187010103 active site 1199187010104 metal binding site [ion binding]; metal-binding site 1199187010105 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1199187010106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187010107 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1199187010108 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1199187010109 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1199187010110 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1199187010111 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1199187010112 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1199187010113 nucleoside/Zn binding site; other site 1199187010114 dimer interface [polypeptide binding]; other site 1199187010115 catalytic motif [active] 1199187010116 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1199187010117 prephenate dehydrogenase; Validated; Region: PRK06545 1199187010118 prephenate dehydrogenase; Validated; Region: PRK08507 1199187010119 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1199187010120 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1199187010121 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1199187010122 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1199187010123 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1199187010124 putative active site [active] 1199187010125 putative substrate binding site [chemical binding]; other site 1199187010126 ATP binding site [chemical binding]; other site 1199187010127 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187010128 catalytic core [active] 1199187010129 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 1199187010130 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187010131 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1199187010132 putative active site [active] 1199187010133 putative substrate binding site [chemical binding]; other site 1199187010134 ATP binding site [chemical binding]; other site 1199187010135 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1199187010136 classical (c) SDRs; Region: SDR_c; cd05233 1199187010137 NAD(P) binding site [chemical binding]; other site 1199187010138 active site 1199187010139 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187010140 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187010141 active site 1199187010142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187010143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010144 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1199187010145 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1199187010146 NAD(P) binding site [chemical binding]; other site 1199187010147 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1199187010148 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187010149 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1199187010150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187010151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187010152 dimerization interface [polypeptide binding]; other site 1199187010153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187010154 dimer interface [polypeptide binding]; other site 1199187010155 phosphorylation site [posttranslational modification] 1199187010156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187010157 ATP binding site [chemical binding]; other site 1199187010158 Mg2+ binding site [ion binding]; other site 1199187010159 G-X-G motif; other site 1199187010160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187010161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187010162 active site 1199187010163 phosphorylation site [posttranslational modification] 1199187010164 intermolecular recognition site; other site 1199187010165 dimerization interface [polypeptide binding]; other site 1199187010166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187010167 DNA binding site [nucleotide binding] 1199187010168 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187010169 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187010170 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187010171 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1199187010172 putative active site [active] 1199187010173 putative substrate binding site [chemical binding]; other site 1199187010174 ATP binding site [chemical binding]; other site 1199187010175 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1199187010176 Winged helix-turn helix; Region: HTH_29; pfam13551 1199187010177 DNA-binding interface [nucleotide binding]; DNA binding site 1199187010178 Homeodomain-like domain; Region: HTH_32; pfam13565 1199187010179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1199187010180 Integrase core domain; Region: rve; pfam00665 1199187010181 Integrase core domain; Region: rve_3; pfam13683 1199187010182 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1199187010183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187010184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187010185 homodimer interface [polypeptide binding]; other site 1199187010186 catalytic residue [active] 1199187010187 GXWXG protein; Region: GXWXG; pfam14231 1199187010188 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1199187010189 TIGR03086 family protein; Region: TIGR03086 1199187010190 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1199187010191 enoyl-CoA hydratase; Provisional; Region: PRK06142 1199187010192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187010193 substrate binding site [chemical binding]; other site 1199187010194 oxyanion hole (OAH) forming residues; other site 1199187010195 trimer interface [polypeptide binding]; other site 1199187010196 Beta-lactamase; Region: Beta-lactamase; pfam00144 1199187010197 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1199187010198 peptide chain release factor 1, archaeal and eukaryotic forms; Region: aRF1/eRF1; TIGR03676 1199187010199 eRF1 domain 3; Region: eRF1_3; pfam03465 1199187010200 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1199187010201 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1199187010202 NAD(P) binding site [chemical binding]; other site 1199187010203 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1199187010204 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1199187010205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1199187010206 catalytic residue [active] 1199187010207 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1199187010208 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1199187010209 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1199187010210 Walker A/P-loop; other site 1199187010211 ATP binding site [chemical binding]; other site 1199187010212 Q-loop/lid; other site 1199187010213 ABC transporter signature motif; other site 1199187010214 Walker B; other site 1199187010215 D-loop; other site 1199187010216 H-loop/switch region; other site 1199187010217 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1199187010218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1199187010219 active site 1199187010220 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1199187010221 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1199187010222 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1199187010223 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1199187010224 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1199187010225 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1199187010226 Predicted membrane protein [Function unknown]; Region: COG2246 1199187010227 GtrA-like protein; Region: GtrA; pfam04138 1199187010228 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1199187010229 FAD binding domain; Region: FAD_binding_4; pfam01565 1199187010230 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1199187010231 short chain dehydrogenase; Provisional; Region: PRK07904 1199187010232 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1199187010233 NAD(P) binding site [chemical binding]; other site 1199187010234 active site 1199187010235 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1199187010236 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1199187010237 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1199187010238 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1199187010239 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1199187010240 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1199187010241 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1199187010242 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1199187010243 DNA binding site [nucleotide binding] 1199187010244 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187010245 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187010246 phosphopeptide binding site; other site 1199187010247 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1199187010248 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1199187010249 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187010250 NSP11; Region: NSP11; pfam06471 1199187010251 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1199187010252 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1199187010253 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1199187010254 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1199187010255 AsnC family; Region: AsnC_trans_reg; pfam01037 1199187010256 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187010257 active site 1199187010258 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187010259 Helix-turn-helix domain; Region: HTH_18; pfam12833 1199187010260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1199187010261 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187010262 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187010263 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1199187010264 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1199187010265 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1199187010266 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187010267 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187010268 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1199187010269 active site 1199187010270 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1199187010271 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187010272 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187010273 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1199187010274 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1199187010275 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1199187010276 acyl-activating enzyme (AAE) consensus motif; other site 1199187010277 active site 1199187010278 Cutinase; Region: Cutinase; pfam01083 1199187010279 Putative esterase; Region: Esterase; pfam00756 1199187010280 Putative esterase; Region: Esterase; pfam00756 1199187010281 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1199187010282 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1199187010283 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1199187010284 active site 1199187010285 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1199187010286 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1199187010287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187010288 UDP-galactopyranose mutase; Region: GLF; pfam03275 1199187010289 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1199187010290 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1199187010291 amidase catalytic site [active] 1199187010292 Zn binding residues [ion binding]; other site 1199187010293 substrate binding site [chemical binding]; other site 1199187010294 LGFP repeat; Region: LGFP; pfam08310 1199187010295 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1199187010296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187010297 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187010298 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1199187010299 putative acyl-acceptor binding pocket; other site 1199187010300 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1199187010301 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187010302 putative acyl-acceptor binding pocket; other site 1199187010303 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187010304 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1199187010305 putative acyl-acceptor binding pocket; other site 1199187010306 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1199187010307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1199187010308 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1199187010309 iron-sulfur cluster [ion binding]; other site 1199187010310 [2Fe-2S] cluster binding site [ion binding]; other site 1199187010311 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1199187010312 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187010313 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1199187010314 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1199187010315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010316 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1199187010317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187010318 S-adenosylmethionine binding site [chemical binding]; other site 1199187010319 Cupin domain; Region: Cupin_2; cl17218 1199187010320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1199187010321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1199187010322 seryl-tRNA synthetase; Provisional; Region: PRK05431 1199187010323 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1199187010324 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1199187010325 dimer interface [polypeptide binding]; other site 1199187010326 active site 1199187010327 motif 1; other site 1199187010328 motif 2; other site 1199187010329 motif 3; other site 1199187010330 Septum formation; Region: Septum_form; pfam13845 1199187010331 Septum formation; Region: Septum_form; pfam13845 1199187010332 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1199187010333 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1199187010334 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187010335 catalytic core [active] 1199187010336 prephenate dehydratase; Provisional; Region: PRK11898 1199187010337 Prephenate dehydratase; Region: PDT; pfam00800 1199187010338 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1199187010339 putative L-Phe binding site [chemical binding]; other site 1199187010340 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1199187010341 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1199187010342 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1199187010343 putative active site [active] 1199187010344 catalytic site [active] 1199187010345 putative metal binding site [ion binding]; other site 1199187010346 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1199187010347 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1199187010348 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1199187010349 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1199187010350 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1199187010351 CopC domain; Region: CopC; pfam04234 1199187010352 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1199187010353 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187010354 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187010355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187010356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010357 DNA polymerase IV; Validated; Region: PRK03858 1199187010358 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1199187010359 active site 1199187010360 DNA binding site [nucleotide binding] 1199187010361 hypothetical protein; Provisional; Region: PRK07945 1199187010362 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1199187010363 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1199187010364 active site 1199187010365 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1199187010366 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187010367 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1199187010368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187010369 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1199187010370 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1199187010371 active site 1199187010372 dimer interface [polypeptide binding]; other site 1199187010373 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1199187010374 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1199187010375 active site 1199187010376 FMN binding site [chemical binding]; other site 1199187010377 substrate binding site [chemical binding]; other site 1199187010378 3Fe-4S cluster binding site [ion binding]; other site 1199187010379 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1199187010380 domain interface; other site 1199187010381 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1199187010382 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1199187010383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187010384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187010385 DNA binding residues [nucleotide binding] 1199187010386 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1199187010387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187010388 NAD(P) binding site [chemical binding]; other site 1199187010389 active site 1199187010390 Domain of unknown function (DUF385); Region: DUF385; cl04387 1199187010391 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1199187010392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187010393 Walker A motif; other site 1199187010394 ATP binding site [chemical binding]; other site 1199187010395 Walker B motif; other site 1199187010396 arginine finger; other site 1199187010397 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1199187010398 catalytic residues [active] 1199187010399 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1199187010400 active site 1199187010401 catalytic residues [active] 1199187010402 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1199187010403 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1199187010404 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1199187010405 EspG family; Region: ESX-1_EspG; pfam14011 1199187010406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1199187010407 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1199187010408 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187010409 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187010410 PPE family; Region: PPE; pfam00823 1199187010411 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1199187010412 putative dimer interface [polypeptide binding]; other site 1199187010413 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187010414 ligand binding site [chemical binding]; other site 1199187010415 Zn binding site [ion binding]; other site 1199187010416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187010417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010418 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187010419 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187010420 substrate binding site [chemical binding]; other site 1199187010421 oxyanion hole (OAH) forming residues; other site 1199187010422 trimer interface [polypeptide binding]; other site 1199187010423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1199187010424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187010425 dimer interface [polypeptide binding]; other site 1199187010426 phosphorylation site [posttranslational modification] 1199187010427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187010428 ATP binding site [chemical binding]; other site 1199187010429 Mg2+ binding site [ion binding]; other site 1199187010430 G-X-G motif; other site 1199187010431 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187010432 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187010433 active site 1199187010434 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1199187010435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187010436 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1199187010437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187010438 dimer interface [polypeptide binding]; other site 1199187010439 conserved gate region; other site 1199187010440 putative PBP binding loops; other site 1199187010441 ABC-ATPase subunit interface; other site 1199187010442 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1199187010443 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1199187010444 substrate binding pocket [chemical binding]; other site 1199187010445 membrane-bound complex binding site; other site 1199187010446 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1199187010447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187010448 Walker A/P-loop; other site 1199187010449 ATP binding site [chemical binding]; other site 1199187010450 Q-loop/lid; other site 1199187010451 ABC transporter signature motif; other site 1199187010452 Walker B; other site 1199187010453 D-loop; other site 1199187010454 H-loop/switch region; other site 1199187010455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187010456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1199187010457 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1199187010458 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187010459 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187010460 Predicted transcriptional regulators [Transcription]; Region: COG1695 1199187010461 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1199187010462 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1199187010463 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1199187010464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1199187010465 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187010466 active site 1199187010467 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1199187010468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187010469 S-adenosylmethionine binding site [chemical binding]; other site 1199187010470 Hemerythrin-like domain; Region: Hr-like; cd12108 1199187010471 proline/glycine betaine transporter; Provisional; Region: PRK10642 1199187010472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187010473 putative substrate translocation pore; other site 1199187010474 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1199187010475 PhoU domain; Region: PhoU; pfam01895 1199187010476 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1199187010477 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1199187010478 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1199187010479 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1199187010480 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1199187010481 putative ligand binding site [chemical binding]; other site 1199187010482 NAD binding site [chemical binding]; other site 1199187010483 catalytic site [active] 1199187010484 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187010485 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1199187010486 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1199187010487 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1199187010488 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1199187010489 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1199187010490 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1199187010491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187010492 S-adenosylmethionine binding site [chemical binding]; other site 1199187010493 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 1199187010494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187010495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187010497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010498 Mannan-binding protein; Region: MVL; pfam12151 1199187010499 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1199187010500 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187010501 mce related protein; Region: MCE; pfam02470 1199187010502 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1199187010503 mce related protein; Region: MCE; pfam02470 1199187010504 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187010505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187010506 mce related protein; Region: MCE; pfam02470 1199187010507 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187010508 mce related protein; Region: MCE; pfam02470 1199187010509 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1199187010510 mce related protein; Region: MCE; pfam02470 1199187010511 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1199187010512 mce related protein; Region: MCE; pfam02470 1199187010513 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187010514 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1199187010515 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187010516 active site 1199187010517 DNA binding site [nucleotide binding] 1199187010518 Int/Topo IB signature motif; other site 1199187010519 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1199187010520 active site 1199187010521 Int/Topo IB signature motif; other site 1199187010522 catalytic residues [active] 1199187010523 DNA binding site [nucleotide binding] 1199187010524 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1199187010525 MULE transposase domain; Region: MULE; pfam10551 1199187010526 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1199187010527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010528 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1199187010529 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1199187010530 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1199187010531 Permease; Region: Permease; pfam02405 1199187010532 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1199187010533 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1199187010534 conserved hypothetical protein; Region: TIGR02246 1199187010535 SnoaL-like domain; Region: SnoaL_3; pfam13474 1199187010536 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1199187010537 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1199187010538 EamA-like transporter family; Region: EamA; pfam00892 1199187010539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1199187010540 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1199187010541 dimerization interface [polypeptide binding]; other site 1199187010542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187010543 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187010544 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187010545 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1199187010546 active site 1199187010547 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1199187010548 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1199187010549 ligand binding site [chemical binding]; other site 1199187010550 flexible hinge region; other site 1199187010551 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1199187010552 putative switch regulator; other site 1199187010553 non-specific DNA interactions [nucleotide binding]; other site 1199187010554 DNA binding site [nucleotide binding] 1199187010555 sequence specific DNA binding site [nucleotide binding]; other site 1199187010556 putative cAMP binding site [chemical binding]; other site 1199187010557 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1199187010558 FAD binding domain; Region: FAD_binding_4; pfam01565 1199187010559 Berberine and berberine like; Region: BBE; pfam08031 1199187010560 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187010561 classical (c) SDRs; Region: SDR_c; cd05233 1199187010562 NAD(P) binding site [chemical binding]; other site 1199187010563 active site 1199187010564 Transport protein; Region: actII; TIGR00833 1199187010565 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187010566 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1199187010567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010568 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1199187010569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187010570 S-adenosylmethionine binding site [chemical binding]; other site 1199187010571 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187010572 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1199187010573 putative acyl-acceptor binding pocket; other site 1199187010574 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1199187010575 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1199187010576 Walker A motif; other site 1199187010577 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1199187010578 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1199187010579 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1199187010580 ATP binding site [chemical binding]; other site 1199187010581 Walker B motif; other site 1199187010582 DNA binding loops [nucleotide binding] 1199187010583 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1199187010584 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1199187010585 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1199187010586 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1199187010587 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1199187010588 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1199187010589 dimer interface [polypeptide binding]; other site 1199187010590 ssDNA binding site [nucleotide binding]; other site 1199187010591 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1199187010592 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1199187010593 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1199187010594 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1199187010595 conserved cys residue [active] 1199187010596 Predicted integral membrane protein [Function unknown]; Region: COG5650 1199187010597 Transglycosylase; Region: Transgly; pfam00912 1199187010598 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1199187010599 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1199187010600 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1199187010601 Predicted transcriptional regulators [Transcription]; Region: COG1695 1199187010602 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1199187010603 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1199187010604 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1199187010605 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187010606 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187010607 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1199187010608 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1199187010609 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187010610 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1199187010611 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1199187010612 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187010613 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1199187010614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187010615 DNA-binding site [nucleotide binding]; DNA binding site 1199187010616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1199187010617 substrate binding pocket [chemical binding]; other site 1199187010618 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1199187010619 membrane-bound complex binding site; other site 1199187010620 hinge residues; other site 1199187010621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1199187010622 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1199187010623 dimer interface [polypeptide binding]; other site 1199187010624 conserved gate region; other site 1199187010625 putative PBP binding loops; other site 1199187010626 ABC-ATPase subunit interface; other site 1199187010627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1199187010628 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1199187010629 Walker A/P-loop; other site 1199187010630 ATP binding site [chemical binding]; other site 1199187010631 Q-loop/lid; other site 1199187010632 ABC transporter signature motif; other site 1199187010633 Walker B; other site 1199187010634 D-loop; other site 1199187010635 H-loop/switch region; other site 1199187010636 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1199187010637 MarR family; Region: MarR; pfam01047 1199187010638 short chain dehydrogenase; Provisional; Region: PRK08219 1199187010639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187010640 NAD(P) binding site [chemical binding]; other site 1199187010641 active site 1199187010642 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1199187010643 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187010644 active site 1199187010645 HIGH motif; other site 1199187010646 nucleotide binding site [chemical binding]; other site 1199187010647 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1199187010648 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187010649 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1199187010650 active site 1199187010651 KMSKS motif; other site 1199187010652 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1199187010653 tRNA binding surface [nucleotide binding]; other site 1199187010654 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1199187010655 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1199187010656 hypothetical protein; Validated; Region: PRK00228 1199187010657 H+ Antiporter protein; Region: 2A0121; TIGR00900 1199187010658 TIGR03084 family protein; Region: TIGR03084 1199187010659 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1199187010660 Wyosine base formation; Region: Wyosine_form; pfam08608 1199187010661 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1199187010662 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1199187010663 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1199187010664 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1199187010665 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1199187010666 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1199187010667 NlpC/P60 family; Region: NLPC_P60; pfam00877 1199187010668 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1199187010669 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187010670 non-specific DNA binding site [nucleotide binding]; other site 1199187010671 salt bridge; other site 1199187010672 sequence-specific DNA binding site [nucleotide binding]; other site 1199187010673 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187010674 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187010675 Transcription factor WhiB; Region: Whib; pfam02467 1199187010676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187010677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187010678 active site 1199187010679 Pirin-related protein [General function prediction only]; Region: COG1741 1199187010680 Pirin; Region: Pirin; pfam02678 1199187010681 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1199187010682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1199187010683 Coenzyme A binding pocket [chemical binding]; other site 1199187010684 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187010685 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187010686 active site 1199187010687 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1199187010688 MULE transposase domain; Region: MULE; pfam10551 1199187010689 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1199187010690 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1199187010691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187010692 acyl-activating enzyme (AAE) consensus motif; other site 1199187010693 AMP binding site [chemical binding]; other site 1199187010694 active site 1199187010695 CoA binding site [chemical binding]; other site 1199187010696 acyl carrier protein; Validated; Region: PRK05883 1199187010697 DinB superfamily; Region: DinB_2; pfam12867 1199187010698 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1199187010699 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187010700 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187010701 phosphopeptide binding site; other site 1199187010702 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1199187010703 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1199187010704 phosphopeptide binding site; other site 1199187010705 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1199187010706 active site 1199187010707 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1199187010708 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1199187010709 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1199187010710 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1199187010711 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1199187010712 active site 1199187010713 ATP binding site [chemical binding]; other site 1199187010714 substrate binding site [chemical binding]; other site 1199187010715 activation loop (A-loop); other site 1199187010716 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1199187010717 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1199187010718 active site 1199187010719 ATP binding site [chemical binding]; other site 1199187010720 substrate binding site [chemical binding]; other site 1199187010721 activation loop (A-loop); other site 1199187010722 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1199187010723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1199187010724 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1199187010725 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1199187010726 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1199187010727 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1199187010728 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1199187010729 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1199187010730 glutamine binding [chemical binding]; other site 1199187010731 catalytic triad [active] 1199187010732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1199187010733 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1199187010734 putative septation inhibitor protein; Reviewed; Region: PRK00159 1199187010735 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1199187010736 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1199187010737 active site 1199187010738 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1199187010739 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187010740 Cytochrome P450; Region: p450; cl12078 1199187010741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187010742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010743 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1199187010744 MULE transposase domain; Region: MULE; pfam10551 1199187010745 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1199187010746 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1199187010747 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1199187010748 homodimer interface [polypeptide binding]; other site 1199187010749 active site 1199187010750 TDP-binding site; other site 1199187010751 acceptor substrate-binding pocket; other site 1199187010752 peptide synthase; Provisional; Region: PRK12316 1199187010753 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1199187010754 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1199187010755 active site 1199187010756 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1199187010757 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1199187010758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187010759 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1199187010760 Enoylreductase; Region: PKS_ER; smart00829 1199187010761 NAD(P) binding site [chemical binding]; other site 1199187010762 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1199187010763 KR domain; Region: KR; pfam08659 1199187010764 putative NADP binding site [chemical binding]; other site 1199187010765 active site 1199187010766 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1199187010767 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187010768 PPE family; Region: PPE; pfam00823 1199187010769 Predicted permease; Region: DUF318; cl17795 1199187010770 TIGR03943 family protein; Region: TIGR03943 1199187010771 30S ribosomal protein S18; Provisional; Region: PRK13401 1199187010772 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1199187010773 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1199187010774 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1199187010775 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1199187010776 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1199187010777 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1199187010778 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1199187010779 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1199187010780 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1199187010781 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1199187010782 metal binding site 2 [ion binding]; metal-binding site 1199187010783 putative DNA binding helix; other site 1199187010784 metal binding site 1 [ion binding]; metal-binding site 1199187010785 dimer interface [polypeptide binding]; other site 1199187010786 structural Zn2+ binding site [ion binding]; other site 1199187010787 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1199187010788 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1199187010789 ABC-ATPase subunit interface; other site 1199187010790 dimer interface [polypeptide binding]; other site 1199187010791 putative PBP binding regions; other site 1199187010792 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1199187010793 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1199187010794 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1199187010795 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1199187010796 intersubunit interface [polypeptide binding]; other site 1199187010797 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1199187010798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187010799 Walker A motif; other site 1199187010800 ATP binding site [chemical binding]; other site 1199187010801 Walker B motif; other site 1199187010802 arginine finger; other site 1199187010803 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1199187010804 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1199187010805 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187010806 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1199187010807 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187010808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187010809 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187010810 PPE family; Region: PPE; pfam00823 1199187010811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1199187010812 EspG family; Region: ESX-1_EspG; pfam14011 1199187010813 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1199187010814 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1199187010815 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1199187010816 catalytic residues [active] 1199187010817 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1199187010818 catalytic residues [active] 1199187010819 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1199187010820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187010821 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1199187010822 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1199187010823 Sulfatase; Region: Sulfatase; pfam00884 1199187010824 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1199187010825 putative FMN binding site [chemical binding]; other site 1199187010826 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1199187010827 active site 1199187010828 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1199187010829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1199187010830 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1199187010831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187010832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187010833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1199187010834 nucleotide binding site [chemical binding]; other site 1199187010835 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1199187010836 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1199187010837 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1199187010838 NAD(P) binding site [chemical binding]; other site 1199187010839 substrate binding site [chemical binding]; other site 1199187010840 dimer interface [polypeptide binding]; other site 1199187010841 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1199187010842 active site 1199187010843 catalytic residues [active] 1199187010844 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1199187010845 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1199187010846 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1199187010847 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1199187010848 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1199187010849 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1199187010850 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187010851 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1199187010852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1199187010853 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1199187010854 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187010855 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1199187010856 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187010857 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1199187010858 DNA binding site [nucleotide binding] 1199187010859 active site 1199187010860 Int/Topo IB signature motif; other site 1199187010861 Protein of unknown function (DUF422); Region: DUF422; cl00991 1199187010862 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187010863 Cytochrome P450; Region: p450; cl12078 1199187010864 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1199187010865 trimer interface [polypeptide binding]; other site 1199187010866 active site 1199187010867 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1199187010868 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1199187010869 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1199187010870 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1199187010871 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1199187010872 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1199187010873 SnoaL-like domain; Region: SnoaL_2; pfam12680 1199187010874 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1199187010875 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1199187010876 substrate binding site; other site 1199187010877 tetramer interface; other site 1199187010878 YibE/F-like protein; Region: YibE_F; pfam07907 1199187010879 aminotransferase AlaT; Validated; Region: PRK09265 1199187010880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187010881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187010882 homodimer interface [polypeptide binding]; other site 1199187010883 catalytic residue [active] 1199187010884 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1199187010885 4Fe-4S binding domain; Region: Fer4; pfam00037 1199187010886 Cysteine-rich domain; Region: CCG; pfam02754 1199187010887 Cysteine-rich domain; Region: CCG; pfam02754 1199187010888 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1199187010889 nucleotide binding site [chemical binding]; other site 1199187010890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187010891 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1199187010892 putative substrate translocation pore; other site 1199187010893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1199187010894 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1199187010895 RES domain; Region: RES; smart00953 1199187010896 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1199187010897 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1199187010898 nucleotide binding site [chemical binding]; other site 1199187010899 NEF interaction site [polypeptide binding]; other site 1199187010900 SBD interface [polypeptide binding]; other site 1199187010901 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1199187010902 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1199187010903 dimer interface [polypeptide binding]; other site 1199187010904 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1199187010905 chaperone protein DnaJ; Provisional; Region: PRK14279 1199187010906 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1199187010907 HSP70 interaction site [polypeptide binding]; other site 1199187010908 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1199187010909 Zn binding sites [ion binding]; other site 1199187010910 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1199187010911 dimer interface [polypeptide binding]; other site 1199187010912 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1199187010913 DNA binding residues [nucleotide binding] 1199187010914 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1199187010915 putative dimer interface [polypeptide binding]; other site 1199187010916 Predicted ATPase [General function prediction only]; Region: COG3899 1199187010917 AAA ATPase domain; Region: AAA_16; pfam13191 1199187010918 GAF domain; Region: GAF_3; pfam13492 1199187010919 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1199187010920 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1199187010921 cyclase homology domain; Region: CHD; cd07302 1199187010922 nucleotidyl binding site; other site 1199187010923 metal binding site [ion binding]; metal-binding site 1199187010924 dimer interface [polypeptide binding]; other site 1199187010925 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1199187010926 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1199187010927 substrate binding pocket [chemical binding]; other site 1199187010928 chain length determination region; other site 1199187010929 substrate-Mg2+ binding site; other site 1199187010930 catalytic residues [active] 1199187010931 aspartate-rich region 1; other site 1199187010932 active site lid residues [active] 1199187010933 aspartate-rich region 2; other site 1199187010934 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1199187010935 SCP-2 sterol transfer family; Region: SCP2; cl01225 1199187010936 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1199187010937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1199187010938 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1199187010939 active site 1199187010940 catalytic residues [active] 1199187010941 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1199187010942 heme-binding site [chemical binding]; other site 1199187010943 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1199187010944 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1199187010945 FAD binding pocket [chemical binding]; other site 1199187010946 FAD binding motif [chemical binding]; other site 1199187010947 phosphate binding motif [ion binding]; other site 1199187010948 beta-alpha-beta structure motif; other site 1199187010949 NAD binding pocket [chemical binding]; other site 1199187010950 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1199187010951 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1199187010952 Clp amino terminal domain; Region: Clp_N; pfam02861 1199187010953 Clp amino terminal domain; Region: Clp_N; pfam02861 1199187010954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187010955 Walker A motif; other site 1199187010956 ATP binding site [chemical binding]; other site 1199187010957 Walker B motif; other site 1199187010958 arginine finger; other site 1199187010959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187010960 Walker A motif; other site 1199187010961 ATP binding site [chemical binding]; other site 1199187010962 Walker B motif; other site 1199187010963 arginine finger; other site 1199187010964 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1199187010965 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1199187010966 Helix-turn-helix domain; Region: HTH_38; pfam13936 1199187010967 DNA-binding interface [nucleotide binding]; DNA binding site 1199187010968 Integrase core domain; Region: rve; pfam00665 1199187010969 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1199187010970 classical (c) SDRs; Region: SDR_c; cd05233 1199187010971 NAD(P) binding site [chemical binding]; other site 1199187010972 active site 1199187010973 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1199187010974 active site 1199187010975 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1199187010976 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1199187010977 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1199187010978 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1199187010979 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1199187010980 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1199187010981 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1199187010982 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1199187010983 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1199187010984 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1199187010985 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1199187010986 Peptidase family M50; Region: Peptidase_M50; pfam02163 1199187010987 active site 1199187010988 putative substrate binding region [chemical binding]; other site 1199187010989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187010990 catalytic core [active] 1199187010991 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1199187010992 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1199187010993 GDP-binding site [chemical binding]; other site 1199187010994 ACT binding site; other site 1199187010995 IMP binding site; other site 1199187010996 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1199187010997 CoenzymeA binding site [chemical binding]; other site 1199187010998 subunit interaction site [polypeptide binding]; other site 1199187010999 PHB binding site; other site 1199187011000 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1199187011001 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1199187011002 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1199187011003 active site residue [active] 1199187011004 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1199187011005 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1199187011006 homodimer interface [polypeptide binding]; other site 1199187011007 substrate-cofactor binding pocket; other site 1199187011008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187011009 catalytic residue [active] 1199187011010 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1199187011011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187011012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187011013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187011014 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187011015 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187011016 active site 1199187011017 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187011018 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187011019 active site 1199187011020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187011021 NAD(P) binding site [chemical binding]; other site 1199187011022 active site 1199187011023 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1199187011024 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1199187011025 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187011026 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1199187011027 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1199187011028 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1199187011029 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187011030 phosphate acetyltransferase; Reviewed; Region: PRK05632 1199187011031 DRTGG domain; Region: DRTGG; pfam07085 1199187011032 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1199187011033 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1199187011034 propionate/acetate kinase; Provisional; Region: PRK12379 1199187011035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1199187011036 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1199187011037 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187011038 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1199187011039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187011040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187011041 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1199187011042 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1199187011043 active site 1199187011044 ATP binding site [chemical binding]; other site 1199187011045 substrate binding site [chemical binding]; other site 1199187011046 activation loop (A-loop); other site 1199187011047 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1199187011048 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1199187011049 substrate binding pocket [chemical binding]; other site 1199187011050 membrane-bound complex binding site; other site 1199187011051 hinge residues; other site 1199187011052 NUDIX domain; Region: NUDIX; pfam00293 1199187011053 nudix motif; other site 1199187011054 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1199187011055 active site 1199187011056 thiamine phosphate binding site [chemical binding]; other site 1199187011057 pyrophosphate binding site [ion binding]; other site 1199187011058 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1199187011059 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1199187011060 thiS-thiF/thiG interaction site; other site 1199187011061 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1199187011062 ThiS interaction site; other site 1199187011063 putative active site [active] 1199187011064 tetramer interface [polypeptide binding]; other site 1199187011065 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1199187011066 active site 1199187011067 catalytic triad [active] 1199187011068 oxyanion hole [active] 1199187011069 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1199187011070 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1199187011071 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1199187011072 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1199187011073 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1199187011074 PA/protease or protease-like domain interface [polypeptide binding]; other site 1199187011075 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1199187011076 active site 1199187011077 metal binding site [ion binding]; metal-binding site 1199187011078 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1199187011079 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1199187011080 PA/protease or protease-like domain interface [polypeptide binding]; other site 1199187011081 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1199187011082 Peptidase family M28; Region: Peptidase_M28; pfam04389 1199187011083 active site 1199187011084 metal binding site [ion binding]; metal-binding site 1199187011085 Predicted metalloprotease [General function prediction only]; Region: COG2321 1199187011086 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1199187011087 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1199187011088 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187011089 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1199187011090 MarR family; Region: MarR; pfam01047 1199187011091 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1199187011092 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1199187011093 dimer interface [polypeptide binding]; other site 1199187011094 substrate binding site [chemical binding]; other site 1199187011095 ATP binding site [chemical binding]; other site 1199187011096 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1199187011097 ThiC-associated domain; Region: ThiC-associated; pfam13667 1199187011098 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1199187011099 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1199187011100 putative catalytic site [active] 1199187011101 putative phosphate binding site [ion binding]; other site 1199187011102 active site 1199187011103 metal binding site A [ion binding]; metal-binding site 1199187011104 DNA binding site [nucleotide binding] 1199187011105 putative AP binding site [nucleotide binding]; other site 1199187011106 putative metal binding site B [ion binding]; other site 1199187011107 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1199187011108 active site 1199187011109 catalytic residues [active] 1199187011110 metal binding site [ion binding]; metal-binding site 1199187011111 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1199187011112 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1199187011113 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1199187011114 E-class dimer interface [polypeptide binding]; other site 1199187011115 P-class dimer interface [polypeptide binding]; other site 1199187011116 active site 1199187011117 Cu2+ binding site [ion binding]; other site 1199187011118 Zn2+ binding site [ion binding]; other site 1199187011119 carboxylate-amine ligase; Provisional; Region: PRK13517 1199187011120 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1199187011121 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1199187011122 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187011123 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187011124 enoyl-CoA hydratase; Provisional; Region: PRK08260 1199187011125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187011126 substrate binding site [chemical binding]; other site 1199187011127 oxyanion hole (OAH) forming residues; other site 1199187011128 trimer interface [polypeptide binding]; other site 1199187011129 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1199187011130 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1199187011131 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1199187011132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187011133 Walker A motif; other site 1199187011134 ATP binding site [chemical binding]; other site 1199187011135 Walker B motif; other site 1199187011136 arginine finger; other site 1199187011137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1199187011138 Walker A motif; other site 1199187011139 ATP binding site [chemical binding]; other site 1199187011140 Walker B motif; other site 1199187011141 arginine finger; other site 1199187011142 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1199187011143 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1199187011144 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1199187011145 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1199187011146 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1199187011147 dimer interface [polypeptide binding]; other site 1199187011148 putative functional site; other site 1199187011149 putative MPT binding site; other site 1199187011150 short chain dehydrogenase; Provisional; Region: PRK06197 1199187011151 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1199187011152 putative NAD(P) binding site [chemical binding]; other site 1199187011153 active site 1199187011154 Cupin domain; Region: Cupin_2; pfam07883 1199187011155 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1199187011156 active site 1199187011157 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1199187011158 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1199187011159 ring oligomerisation interface [polypeptide binding]; other site 1199187011160 ATP/Mg binding site [chemical binding]; other site 1199187011161 stacking interactions; other site 1199187011162 hinge regions; other site 1199187011163 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1199187011164 putative active site [active] 1199187011165 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1199187011166 PPE family; Region: PPE; pfam00823 1199187011167 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1199187011168 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1199187011169 active site 1199187011170 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187011171 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1199187011172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187011173 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1199187011174 DinB superfamily; Region: DinB_2; pfam12867 1199187011175 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1199187011176 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1199187011177 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1199187011178 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1199187011179 catalytic residues [active] 1199187011180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187011181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187011182 Tetrahydromethanopterin S-methyltransferase subunit B; Region: MtrB; cl01678 1199187011183 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1199187011184 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1199187011185 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1199187011186 enoyl-CoA hydratase; Provisional; Region: PRK12478 1199187011187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187011188 substrate binding site [chemical binding]; other site 1199187011189 oxyanion hole (OAH) forming residues; other site 1199187011190 trimer interface [polypeptide binding]; other site 1199187011191 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1199187011192 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187011193 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1199187011194 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1199187011195 NAD(P) binding site [chemical binding]; other site 1199187011196 catalytic residues [active] 1199187011197 Protein of unknown function (DUF779); Region: DUF779; cl01432 1199187011198 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1199187011199 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1199187011200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187011201 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1199187011202 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1199187011203 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1199187011204 Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...; Region: Calpain_III; cl00165 1199187011205 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1199187011206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187011207 non-specific DNA binding site [nucleotide binding]; other site 1199187011208 salt bridge; other site 1199187011209 sequence-specific DNA binding site [nucleotide binding]; other site 1199187011210 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1199187011211 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1199187011212 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1199187011213 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1199187011214 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1199187011215 active site 1199187011216 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1199187011217 active site 2 [active] 1199187011218 isocitrate lyase; Provisional; Region: PRK15063 1199187011219 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1199187011220 tetramer interface [polypeptide binding]; other site 1199187011221 active site 1199187011222 Mg2+/Mn2+ binding site [ion binding]; other site 1199187011223 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1199187011224 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1199187011225 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1199187011226 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1199187011227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187011228 S-adenosylmethionine binding site [chemical binding]; other site 1199187011229 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1199187011230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187011231 S-adenosylmethionine binding site [chemical binding]; other site 1199187011232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187011233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187011234 Predicted membrane protein [Function unknown]; Region: COG2733 1199187011235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187011236 non-specific DNA binding site [nucleotide binding]; other site 1199187011237 salt bridge; other site 1199187011238 sequence-specific DNA binding site [nucleotide binding]; other site 1199187011239 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1199187011240 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1199187011241 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 1199187011242 catalytic residue [active] 1199187011243 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1199187011244 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1199187011245 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1199187011246 putative active site [active] 1199187011247 catalytic triad [active] 1199187011248 putative dimer interface [polypeptide binding]; other site 1199187011249 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1199187011250 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1199187011251 FAD binding domain; Region: FAD_binding_4; pfam01565 1199187011252 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1199187011253 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1199187011254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1199187011255 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1199187011256 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1199187011257 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1199187011258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1199187011259 NAD(P) binding site [chemical binding]; other site 1199187011260 active site 1199187011261 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1199187011262 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1199187011263 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1199187011264 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1199187011265 putative ADP-binding pocket [chemical binding]; other site 1199187011266 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1199187011267 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187011268 catalytic core [active] 1199187011269 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187011270 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1199187011271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1199187011272 dimer interface [polypeptide binding]; other site 1199187011273 phosphorylation site [posttranslational modification] 1199187011274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1199187011275 ATP binding site [chemical binding]; other site 1199187011276 Mg2+ binding site [ion binding]; other site 1199187011277 G-X-G motif; other site 1199187011278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1199187011279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187011280 active site 1199187011281 phosphorylation site [posttranslational modification] 1199187011282 intermolecular recognition site; other site 1199187011283 dimerization interface [polypeptide binding]; other site 1199187011284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1199187011285 DNA binding site [nucleotide binding] 1199187011286 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1199187011287 nudix motif; other site 1199187011288 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1199187011289 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1199187011290 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1199187011291 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1199187011292 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1199187011293 DNA interaction; other site 1199187011294 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1199187011295 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1199187011296 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1199187011297 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1199187011298 DNA binding domain, excisionase family; Region: excise; TIGR01764 1199187011299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1199187011300 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1199187011301 putative NAD(P) binding site [chemical binding]; other site 1199187011302 active site 1199187011303 putative substrate binding site [chemical binding]; other site 1199187011304 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1199187011305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1199187011306 putative acyl-acceptor binding pocket; other site 1199187011307 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1199187011308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1199187011309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187011310 S-adenosylmethionine binding site [chemical binding]; other site 1199187011311 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1199187011312 active site 1199187011313 catalytic site [active] 1199187011314 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1199187011315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1199187011316 motif II; other site 1199187011317 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1199187011318 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1199187011319 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1199187011320 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1199187011321 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1199187011322 tRNA; other site 1199187011323 putative tRNA binding site [nucleotide binding]; other site 1199187011324 putative NADP binding site [chemical binding]; other site 1199187011325 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1199187011326 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1199187011327 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1199187011328 domain interfaces; other site 1199187011329 active site 1199187011330 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1199187011331 active site 1199187011332 homodimer interface [polypeptide binding]; other site 1199187011333 SAM binding site [chemical binding]; other site 1199187011334 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1199187011335 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1199187011336 active site 1199187011337 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1199187011338 dimer interface [polypeptide binding]; other site 1199187011339 active site 1199187011340 Schiff base residues; other site 1199187011341 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187011342 anti sigma factor interaction site; other site 1199187011343 regulatory phosphorylation site [posttranslational modification]; other site 1199187011344 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187011345 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1199187011346 active site 1199187011347 catalytic triad [active] 1199187011348 oxyanion hole [active] 1199187011349 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187011350 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1199187011351 S-formylglutathione hydrolase; Region: PLN02442 1199187011352 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1199187011353 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1199187011354 active site 1199187011355 dimer interface [polypeptide binding]; other site 1199187011356 non-prolyl cis peptide bond; other site 1199187011357 insertion regions; other site 1199187011358 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1199187011359 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1199187011360 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1199187011361 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1199187011362 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1199187011363 putative active site pocket [active] 1199187011364 metal binding site [ion binding]; metal-binding site 1199187011365 Domain of unknown function (DUF385); Region: DUF385; cl04387 1199187011366 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1199187011367 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1199187011368 inhibitor-cofactor binding pocket; inhibition site 1199187011369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187011370 catalytic residue [active] 1199187011371 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1199187011372 catalytic core [active] 1199187011373 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1199187011374 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1199187011375 catalytic residues [active] 1199187011376 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1199187011377 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1199187011378 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1199187011379 ResB-like family; Region: ResB; pfam05140 1199187011380 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1199187011381 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1199187011382 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1199187011383 P-loop; other site 1199187011384 Magnesium ion binding site [ion binding]; other site 1199187011385 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1199187011386 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1199187011387 dimer interface [polypeptide binding]; other site 1199187011388 active site 1199187011389 CoA binding pocket [chemical binding]; other site 1199187011390 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1199187011391 UbiA prenyltransferase family; Region: UbiA; pfam01040 1199187011392 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1199187011393 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1199187011394 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1199187011395 Ligand binding site; other site 1199187011396 Putative Catalytic site; other site 1199187011397 DXD motif; other site 1199187011398 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1199187011399 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1199187011400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187011401 acyl-activating enzyme (AAE) consensus motif; other site 1199187011402 AMP binding site [chemical binding]; other site 1199187011403 active site 1199187011404 CoA binding site [chemical binding]; other site 1199187011405 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1199187011406 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1199187011407 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1199187011408 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1199187011409 active site 1199187011410 short chain dehydrogenase; Provisional; Region: PRK05866 1199187011411 classical (c) SDRs; Region: SDR_c; cd05233 1199187011412 NAD(P) binding site [chemical binding]; other site 1199187011413 active site 1199187011414 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187011415 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1199187011416 substrate binding site [chemical binding]; other site 1199187011417 oxyanion hole (OAH) forming residues; other site 1199187011418 trimer interface [polypeptide binding]; other site 1199187011419 Domain of unknown function (DUF385); Region: DUF385; cl04387 1199187011420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187011421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187011422 active site 1199187011423 catalytic tetrad [active] 1199187011424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187011425 acyl-CoA synthetase; Validated; Region: PRK06188 1199187011426 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187011427 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1199187011428 acyl-activating enzyme (AAE) consensus motif; other site 1199187011429 acyl-activating enzyme (AAE) consensus motif; other site 1199187011430 putative AMP binding site [chemical binding]; other site 1199187011431 putative active site [active] 1199187011432 putative CoA binding site [chemical binding]; other site 1199187011433 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1199187011434 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1199187011435 active site 1199187011436 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1199187011437 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1199187011438 active site 1199187011439 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1199187011440 TAP-like protein; Region: Abhydrolase_4; pfam08386 1199187011441 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1199187011442 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1199187011443 dimer interface [polypeptide binding]; other site 1199187011444 tetramer interface [polypeptide binding]; other site 1199187011445 PYR/PP interface [polypeptide binding]; other site 1199187011446 TPP binding site [chemical binding]; other site 1199187011447 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1199187011448 TPP-binding site; other site 1199187011449 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1199187011450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1199187011451 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1199187011452 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1199187011453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187011454 S-adenosylmethionine binding site [chemical binding]; other site 1199187011455 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1199187011456 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1199187011457 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1199187011458 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1199187011459 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1199187011460 substrate binding pocket [chemical binding]; other site 1199187011461 chain length determination region; other site 1199187011462 substrate-Mg2+ binding site; other site 1199187011463 catalytic residues [active] 1199187011464 aspartate-rich region 1; other site 1199187011465 active site lid residues [active] 1199187011466 aspartate-rich region 2; other site 1199187011467 heat shock protein HtpX; Provisional; Region: PRK03072 1199187011468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1199187011469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187011470 salt bridge; other site 1199187011471 non-specific DNA binding site [nucleotide binding]; other site 1199187011472 sequence-specific DNA binding site [nucleotide binding]; other site 1199187011473 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1199187011474 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1199187011475 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1199187011476 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1199187011477 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1199187011478 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1199187011479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187011480 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 1199187011481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1199187011482 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1199187011483 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187011484 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187011485 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1199187011486 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1199187011487 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187011488 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187011489 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1199187011490 Cytochrome P450; Region: p450; cl12078 1199187011491 NYN domain; Region: NYN; pfam01936 1199187011492 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1199187011493 putative metal binding site [ion binding]; other site 1199187011494 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 1199187011495 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187011496 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187011497 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1199187011498 putative hydrolase; Provisional; Region: PRK11460 1199187011499 Predicted membrane protein [Function unknown]; Region: COG1289 1199187011500 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1199187011501 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1199187011502 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1199187011503 dimer interface [polypeptide binding]; other site 1199187011504 active site 1199187011505 galactokinase; Provisional; Region: PRK00555 1199187011506 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1199187011507 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1199187011508 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1199187011509 PAS fold; Region: PAS_3; pfam08447 1199187011510 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1199187011511 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1199187011512 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1199187011513 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1199187011514 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1199187011515 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187011516 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187011517 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1199187011518 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1199187011519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1199187011520 DNA-binding site [nucleotide binding]; DNA binding site 1199187011521 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187011522 Permease; Region: Permease; pfam02405 1199187011523 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1199187011524 Permease; Region: Permease; pfam02405 1199187011525 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187011526 mce related protein; Region: MCE; pfam02470 1199187011527 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1199187011528 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1199187011529 mce related protein; Region: MCE; pfam02470 1199187011530 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187011531 mce related protein; Region: MCE; pfam02470 1199187011532 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187011533 mce related protein; Region: MCE; pfam02470 1199187011534 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187011535 mce related protein; Region: MCE; pfam02470 1199187011536 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1199187011537 mce related protein; Region: MCE; pfam02470 1199187011538 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1199187011539 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1199187011540 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1199187011541 AAA domain; Region: AAA_30; pfam13604 1199187011542 Family description; Region: UvrD_C_2; pfam13538 1199187011543 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1199187011544 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1199187011545 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1199187011546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187011547 S-adenosylmethionine binding site [chemical binding]; other site 1199187011548 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1199187011549 FMN binding site [chemical binding]; other site 1199187011550 dimer interface [polypeptide binding]; other site 1199187011551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187011552 S-adenosylmethionine binding site [chemical binding]; other site 1199187011553 cyanate hydratase; Validated; Region: PRK02866 1199187011554 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1199187011555 oligomer interface [polypeptide binding]; other site 1199187011556 active site 1199187011557 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1199187011558 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1199187011559 active site 1199187011560 nucleophile elbow; other site 1199187011561 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1199187011562 [4Fe-4S] binding site [ion binding]; other site 1199187011563 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1199187011564 molybdopterin cofactor binding site; other site 1199187011565 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1199187011566 molybdopterin cofactor binding site; other site 1199187011567 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187011568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187011569 substrate binding site [chemical binding]; other site 1199187011570 oxyanion hole (OAH) forming residues; other site 1199187011571 trimer interface [polypeptide binding]; other site 1199187011572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1199187011573 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1199187011574 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1199187011575 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1199187011576 active site 1199187011577 catalytic site [active] 1199187011578 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1199187011579 active site 1199187011580 catalytic site [active] 1199187011581 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1199187011582 active site 1199187011583 catalytic site [active] 1199187011584 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1199187011585 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1199187011586 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1199187011587 putative homodimer interface [polypeptide binding]; other site 1199187011588 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1199187011589 heterodimer interface [polypeptide binding]; other site 1199187011590 homodimer interface [polypeptide binding]; other site 1199187011591 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1199187011592 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1199187011593 23S rRNA interface [nucleotide binding]; other site 1199187011594 L7/L12 interface [polypeptide binding]; other site 1199187011595 putative thiostrepton binding site; other site 1199187011596 L25 interface [polypeptide binding]; other site 1199187011597 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1199187011598 mRNA/rRNA interface [nucleotide binding]; other site 1199187011599 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1199187011600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187011601 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1199187011602 DNA binding residues [nucleotide binding] 1199187011603 YCII-related domain; Region: YCII; cl00999 1199187011604 YCII-related domain; Region: YCII; cl00999 1199187011605 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1199187011606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187011607 S-adenosylmethionine binding site [chemical binding]; other site 1199187011608 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1199187011609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1199187011610 S-adenosylmethionine binding site [chemical binding]; other site 1199187011611 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1199187011612 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1199187011613 TAP-like protein; Region: Abhydrolase_4; pfam08386 1199187011614 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1199187011615 ABC1 family; Region: ABC1; pfam03109 1199187011616 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1199187011617 active site 1199187011618 ATP binding site [chemical binding]; other site 1199187011619 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1199187011620 DinB superfamily; Region: DinB_2; pfam12867 1199187011621 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1199187011622 active site 1199187011623 catalytic site [active] 1199187011624 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1199187011625 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1199187011626 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1199187011627 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1199187011628 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1199187011629 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1199187011630 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1199187011631 23S rRNA interface [nucleotide binding]; other site 1199187011632 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1199187011633 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1199187011634 core dimer interface [polypeptide binding]; other site 1199187011635 peripheral dimer interface [polypeptide binding]; other site 1199187011636 L10 interface [polypeptide binding]; other site 1199187011637 L11 interface [polypeptide binding]; other site 1199187011638 putative EF-Tu interaction site [polypeptide binding]; other site 1199187011639 putative EF-G interaction site [polypeptide binding]; other site 1199187011640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187011641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187011642 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1199187011643 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1199187011644 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1199187011645 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1199187011646 Walker A/P-loop; other site 1199187011647 ATP binding site [chemical binding]; other site 1199187011648 Q-loop/lid; other site 1199187011649 ABC transporter signature motif; other site 1199187011650 Walker B; other site 1199187011651 D-loop; other site 1199187011652 H-loop/switch region; other site 1199187011653 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1199187011654 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1199187011655 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1199187011656 RPB10 interaction site [polypeptide binding]; other site 1199187011657 RPB1 interaction site [polypeptide binding]; other site 1199187011658 RPB11 interaction site [polypeptide binding]; other site 1199187011659 RPB3 interaction site [polypeptide binding]; other site 1199187011660 RPB12 interaction site [polypeptide binding]; other site 1199187011661 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1199187011662 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1199187011663 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1199187011664 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1199187011665 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1199187011666 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1199187011667 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1199187011668 G-loop; other site 1199187011669 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1199187011670 DNA binding site [nucleotide binding] 1199187011671 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1199187011672 endonuclease IV; Provisional; Region: PRK01060 1199187011673 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1199187011674 AP (apurinic/apyrimidinic) site pocket; other site 1199187011675 DNA interaction; other site 1199187011676 Metal-binding active site; metal-binding site 1199187011677 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1199187011678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187011679 active site 1199187011680 enoyl-CoA hydratase; Provisional; Region: PRK12478 1199187011681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187011682 substrate binding site [chemical binding]; other site 1199187011683 oxyanion hole (OAH) forming residues; other site 1199187011684 trimer interface [polypeptide binding]; other site 1199187011685 PaaX-like protein; Region: PaaX; pfam07848 1199187011686 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1199187011687 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1199187011688 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1199187011689 substrate binding site [chemical binding]; other site 1199187011690 oxyanion hole (OAH) forming residues; other site 1199187011691 trimer interface [polypeptide binding]; other site 1199187011692 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1199187011693 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1199187011694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187011695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187011696 WHG domain; Region: WHG; pfam13305 1199187011697 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1199187011698 S17 interaction site [polypeptide binding]; other site 1199187011699 S8 interaction site; other site 1199187011700 16S rRNA interaction site [nucleotide binding]; other site 1199187011701 streptomycin interaction site [chemical binding]; other site 1199187011702 23S rRNA interaction site [nucleotide binding]; other site 1199187011703 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1199187011704 30S ribosomal protein S7; Validated; Region: PRK05302 1199187011705 elongation factor G; Reviewed; Region: PRK00007 1199187011706 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1199187011707 G1 box; other site 1199187011708 putative GEF interaction site [polypeptide binding]; other site 1199187011709 GTP/Mg2+ binding site [chemical binding]; other site 1199187011710 Switch I region; other site 1199187011711 G2 box; other site 1199187011712 G3 box; other site 1199187011713 Switch II region; other site 1199187011714 G4 box; other site 1199187011715 G5 box; other site 1199187011716 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1199187011717 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1199187011718 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1199187011719 elongation factor Tu; Reviewed; Region: PRK00049 1199187011720 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1199187011721 G1 box; other site 1199187011722 GEF interaction site [polypeptide binding]; other site 1199187011723 GTP/Mg2+ binding site [chemical binding]; other site 1199187011724 Switch I region; other site 1199187011725 G2 box; other site 1199187011726 G3 box; other site 1199187011727 Switch II region; other site 1199187011728 G4 box; other site 1199187011729 G5 box; other site 1199187011730 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1199187011731 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1199187011732 Antibiotic Binding Site [chemical binding]; other site 1199187011733 PE family; Region: PE; pfam00934 1199187011734 Short C-terminal domain; Region: SHOCT; pfam09851 1199187011735 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187011736 classical (c) SDRs; Region: SDR_c; cd05233 1199187011737 NAD(P) binding site [chemical binding]; other site 1199187011738 active site 1199187011739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1199187011740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187011741 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1199187011742 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1199187011743 active site 1199187011744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1199187011745 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1199187011746 active site 1199187011747 catalytic tetrad [active] 1199187011748 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1199187011749 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1199187011750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187011751 mycofactocin precursor; Region: mycofactocin; TIGR03969 1199187011752 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1199187011753 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1199187011754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1199187011755 FeS/SAM binding site; other site 1199187011756 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1199187011757 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1199187011758 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1199187011759 phosphate binding site [ion binding]; other site 1199187011760 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1199187011761 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1199187011762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1199187011763 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1199187011764 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1199187011765 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1199187011766 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1199187011767 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1199187011768 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1199187011769 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1199187011770 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1199187011771 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1199187011772 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1199187011773 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1199187011774 putative translocon binding site; other site 1199187011775 protein-rRNA interface [nucleotide binding]; other site 1199187011776 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1199187011777 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1199187011778 G-X-X-G motif; other site 1199187011779 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1199187011780 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1199187011781 23S rRNA interface [nucleotide binding]; other site 1199187011782 5S rRNA interface [nucleotide binding]; other site 1199187011783 putative antibiotic binding site [chemical binding]; other site 1199187011784 L25 interface [polypeptide binding]; other site 1199187011785 L27 interface [polypeptide binding]; other site 1199187011786 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1199187011787 putative translocon interaction site; other site 1199187011788 signal recognition particle (SRP54) interaction site; other site 1199187011789 L23 interface [polypeptide binding]; other site 1199187011790 trigger factor interaction site; other site 1199187011791 23S rRNA interface [nucleotide binding]; other site 1199187011792 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1199187011793 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1199187011794 Sulfatase; Region: Sulfatase; pfam00884 1199187011795 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1199187011796 PBP superfamily domain; Region: PBP_like_2; cl17296 1199187011797 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1199187011798 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1199187011799 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1199187011800 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1199187011801 active site 1199187011802 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1199187011803 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1199187011804 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1199187011805 RNA binding site [nucleotide binding]; other site 1199187011806 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1199187011807 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1199187011808 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1199187011809 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1199187011810 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1199187011811 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1199187011812 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1199187011813 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1199187011814 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1199187011815 5S rRNA interface [nucleotide binding]; other site 1199187011816 L27 interface [polypeptide binding]; other site 1199187011817 23S rRNA interface [nucleotide binding]; other site 1199187011818 L5 interface [polypeptide binding]; other site 1199187011819 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1199187011820 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1199187011821 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1199187011822 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1199187011823 23S rRNA binding site [nucleotide binding]; other site 1199187011824 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1199187011825 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187011826 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1199187011827 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1199187011828 tandem repeat interface [polypeptide binding]; other site 1199187011829 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1199187011830 oligomer interface [polypeptide binding]; other site 1199187011831 active site residues [active] 1199187011832 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1199187011833 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1199187011834 tandem repeat interface [polypeptide binding]; other site 1199187011835 oligomer interface [polypeptide binding]; other site 1199187011836 active site residues [active] 1199187011837 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187011838 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187011839 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187011840 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187011841 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187011842 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187011843 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1199187011844 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1199187011845 NAD(P) binding site [chemical binding]; other site 1199187011846 L-fuculose-phosphate aldolase; Validated; Region: PRK05874 1199187011847 intersubunit interface [polypeptide binding]; other site 1199187011848 active site 1199187011849 Zn2+ binding site [ion binding]; other site 1199187011850 glyoxylate reductase; Reviewed; Region: PRK13243 1199187011851 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1199187011852 NAD binding site [chemical binding]; other site 1199187011853 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1199187011854 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1199187011855 nucleotide binding site [chemical binding]; other site 1199187011856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1199187011857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1199187011858 Coenzyme A binding pocket [chemical binding]; other site 1199187011859 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1199187011860 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1199187011861 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1199187011862 SecY translocase; Region: SecY; pfam00344 1199187011863 adenylate kinase; Reviewed; Region: adk; PRK00279 1199187011864 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1199187011865 AMP-binding site [chemical binding]; other site 1199187011866 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1199187011867 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1199187011868 active site 1199187011869 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1199187011870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187011871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187011872 DNA binding residues [nucleotide binding] 1199187011873 Putative zinc-finger; Region: zf-HC2; pfam13490 1199187011874 hypothetical protein; Provisional; Region: PRK07236 1199187011875 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1199187011876 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1199187011877 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1199187011878 FtsX-like permease family; Region: FtsX; pfam02687 1199187011879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1199187011880 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1199187011881 Walker A/P-loop; other site 1199187011882 ATP binding site [chemical binding]; other site 1199187011883 Q-loop/lid; other site 1199187011884 ABC transporter signature motif; other site 1199187011885 Walker B; other site 1199187011886 D-loop; other site 1199187011887 H-loop/switch region; other site 1199187011888 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1199187011889 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1199187011890 PYR/PP interface [polypeptide binding]; other site 1199187011891 dimer interface [polypeptide binding]; other site 1199187011892 TPP binding site [chemical binding]; other site 1199187011893 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1199187011894 TPP-binding site [chemical binding]; other site 1199187011895 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1199187011896 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1199187011897 active site 1199187011898 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1199187011899 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1199187011900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187011901 homodimer interface [polypeptide binding]; other site 1199187011902 catalytic residue [active] 1199187011903 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1199187011904 MarR family; Region: MarR; pfam01047 1199187011905 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1199187011906 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1199187011907 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187011908 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1199187011909 substrate binding pocket [chemical binding]; other site 1199187011910 FAD binding site [chemical binding]; other site 1199187011911 catalytic base [active] 1199187011912 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1199187011913 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1199187011914 tetrameric interface [polypeptide binding]; other site 1199187011915 NAD binding site [chemical binding]; other site 1199187011916 catalytic residues [active] 1199187011917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1199187011918 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1199187011919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187011920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187011921 DNA binding residues [nucleotide binding] 1199187011922 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1199187011923 iron-sulfur cluster [ion binding]; other site 1199187011924 [2Fe-2S] cluster binding site [ion binding]; other site 1199187011925 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1199187011926 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1199187011927 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1199187011928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1199187011929 active site 1199187011930 metal binding site [ion binding]; metal-binding site 1199187011931 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187011932 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187011933 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1199187011934 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1199187011935 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1199187011936 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1199187011937 NAD binding site [chemical binding]; other site 1199187011938 substrate binding site [chemical binding]; other site 1199187011939 homodimer interface [polypeptide binding]; other site 1199187011940 active site 1199187011941 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1199187011942 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1199187011943 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1199187011944 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1199187011945 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1199187011946 rRNA binding site [nucleotide binding]; other site 1199187011947 predicted 30S ribosome binding site; other site 1199187011948 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1199187011949 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1199187011950 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1199187011951 30S ribosomal protein S11; Validated; Region: PRK05309 1199187011952 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1199187011953 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1199187011954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1199187011955 RNA binding surface [nucleotide binding]; other site 1199187011956 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1199187011957 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1199187011958 alphaNTD homodimer interface [polypeptide binding]; other site 1199187011959 alphaNTD - beta interaction site [polypeptide binding]; other site 1199187011960 alphaNTD - beta' interaction site [polypeptide binding]; other site 1199187011961 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1199187011962 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1199187011963 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1199187011964 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1199187011965 active site 1199187011966 dimerization interface 3.5A [polypeptide binding]; other site 1199187011967 Cutinase; Region: Cutinase; pfam01083 1199187011968 Cutinase; Region: Cutinase; pfam01083 1199187011969 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1199187011970 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1199187011971 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1199187011972 active site 1199187011973 catalytic residues [active] 1199187011974 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 1199187011975 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1199187011976 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187011977 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1199187011978 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187011979 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187011980 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1199187011981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1199187011982 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1199187011983 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1199187011984 23S rRNA interface [nucleotide binding]; other site 1199187011985 L3 interface [polypeptide binding]; other site 1199187011986 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1199187011987 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1199187011988 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1199187011989 active site 1199187011990 substrate binding site [chemical binding]; other site 1199187011991 metal binding site [ion binding]; metal-binding site 1199187011992 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1199187011993 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1199187011994 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1199187011995 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1199187011996 glutaminase active site [active] 1199187011997 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1199187011998 dimer interface [polypeptide binding]; other site 1199187011999 active site 1199187012000 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1199187012001 dimer interface [polypeptide binding]; other site 1199187012002 active site 1199187012003 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1199187012004 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1199187012005 putative substrate binding site [chemical binding]; other site 1199187012006 putative ATP binding site [chemical binding]; other site 1199187012007 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1199187012008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1199187012009 catalytic residue [active] 1199187012010 alanine racemase; Reviewed; Region: alr; PRK00053 1199187012011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1199187012012 active site 1199187012013 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1199187012014 dimer interface [polypeptide binding]; other site 1199187012015 substrate binding site [chemical binding]; other site 1199187012016 catalytic residues [active] 1199187012017 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1199187012018 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1199187012019 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1199187012020 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1199187012021 Glycoprotease family; Region: Peptidase_M22; pfam00814 1199187012022 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1199187012023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1199187012024 Coenzyme A binding pocket [chemical binding]; other site 1199187012025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1199187012026 UGMP family protein; Validated; Region: PRK09604 1199187012027 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1199187012028 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1199187012029 oligomerisation interface [polypeptide binding]; other site 1199187012030 mobile loop; other site 1199187012031 roof hairpin; other site 1199187012032 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1199187012033 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1199187012034 ring oligomerisation interface [polypeptide binding]; other site 1199187012035 ATP/Mg binding site [chemical binding]; other site 1199187012036 stacking interactions; other site 1199187012037 hinge regions; other site 1199187012038 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1199187012039 dimerization interface [polypeptide binding]; other site 1199187012040 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1199187012041 cyclase homology domain; Region: CHD; cd07302 1199187012042 nucleotidyl binding site; other site 1199187012043 metal binding site [ion binding]; metal-binding site 1199187012044 dimer interface [polypeptide binding]; other site 1199187012045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1199187012046 non-specific DNA binding site [nucleotide binding]; other site 1199187012047 salt bridge; other site 1199187012048 sequence-specific DNA binding site [nucleotide binding]; other site 1199187012049 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1199187012050 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1199187012051 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1199187012052 hypothetical protein; Provisional; Region: PRK06185 1199187012053 hypothetical protein; Provisional; Region: PRK07236 1199187012054 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1199187012055 E-class dimer interface [polypeptide binding]; other site 1199187012056 P-class dimer interface [polypeptide binding]; other site 1199187012057 active site 1199187012058 Cu2+ binding site [ion binding]; other site 1199187012059 Zn2+ binding site [ion binding]; other site 1199187012060 Transcription factor WhiB; Region: Whib; pfam02467 1199187012061 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1199187012062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187012063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1199187012064 DNA binding residues [nucleotide binding] 1199187012065 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1199187012066 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1199187012067 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1199187012068 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1199187012069 phosphate binding site [ion binding]; other site 1199187012070 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1199187012071 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1199187012072 phosphate binding site [ion binding]; other site 1199187012073 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1199187012074 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1199187012075 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1199187012076 classical (c) SDRs; Region: SDR_c; cd05233 1199187012077 NAD(P) binding site [chemical binding]; other site 1199187012078 active site 1199187012079 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1199187012080 metal-binding site [ion binding] 1199187012081 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1199187012082 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1199187012083 metal-binding site [ion binding] 1199187012084 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1199187012085 Predicted esterase [General function prediction only]; Region: COG0627 1199187012086 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1199187012087 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1199187012088 NodB motif; other site 1199187012089 active site 1199187012090 catalytic site [active] 1199187012091 metal binding site [ion binding]; metal-binding site 1199187012092 MarR family; Region: MarR_2; pfam12802 1199187012093 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1199187012094 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1199187012095 Secretory lipase; Region: LIP; pfam03583 1199187012096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1199187012097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187012098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187012099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1199187012100 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1199187012101 classical (c) SDRs; Region: SDR_c; cd05233 1199187012102 NAD(P) binding site [chemical binding]; other site 1199187012103 active site 1199187012104 acyl-CoA synthetase; Provisional; Region: PRK13388 1199187012105 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1199187012106 acyl-activating enzyme (AAE) consensus motif; other site 1199187012107 AMP binding site [chemical binding]; other site 1199187012108 active site 1199187012109 CoA binding site [chemical binding]; other site 1199187012110 Predicted transcriptional regulators [Transcription]; Region: COG1695 1199187012111 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1199187012112 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1199187012113 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187012114 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1199187012115 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187012116 active site 1199187012117 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187012118 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187012119 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1199187012120 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1199187012121 Amidohydrolase; Region: Amidohydro_2; pfam04909 1199187012122 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1199187012123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1199187012124 DNA binding site [nucleotide binding] 1199187012125 domain linker motif; other site 1199187012126 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1199187012127 dimerization interface [polypeptide binding]; other site 1199187012128 ligand binding site [chemical binding]; other site 1199187012129 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1199187012130 DUF35 OB-fold domain; Region: DUF35; pfam01796 1199187012131 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1199187012132 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1199187012133 active site 1199187012134 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187012135 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1199187012136 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187012137 active site 1199187012138 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1199187012139 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1199187012140 active site 1199187012141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187012142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187012143 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1199187012144 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1199187012145 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1199187012146 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 1199187012147 putative active site [active] 1199187012148 catalytic residue [active] 1199187012149 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1199187012150 anti sigma factor interaction site; other site 1199187012151 regulatory phosphorylation site [posttranslational modification]; other site 1199187012152 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1199187012153 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187012154 putative active site [active] 1199187012155 ATP binding site [chemical binding]; other site 1199187012156 putative substrate binding site [chemical binding]; other site 1199187012157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1199187012158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1199187012159 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1199187012160 Ecdysteroid kinase; Region: EcKinase; cl17738 1199187012161 Phosphotransferase enzyme family; Region: APH; pfam01636 1199187012162 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 1199187012163 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1199187012164 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187012165 active site 1199187012166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1199187012167 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1199187012168 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1199187012169 [2Fe-2S] cluster binding site [ion binding]; other site 1199187012170 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1199187012171 putative alpha subunit interface [polypeptide binding]; other site 1199187012172 putative active site [active] 1199187012173 putative substrate binding site [chemical binding]; other site 1199187012174 Fe binding site [ion binding]; other site 1199187012175 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1199187012176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1199187012177 active site 1199187012178 phosphorylation site [posttranslational modification] 1199187012179 intermolecular recognition site; other site 1199187012180 dimerization interface [polypeptide binding]; other site 1199187012181 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1199187012182 DNA binding residues [nucleotide binding] 1199187012183 dimerization interface [polypeptide binding]; other site 1199187012184 Histidine kinase; Region: HisKA_3; pfam07730 1199187012185 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1199187012186 Transport protein; Region: actII; TIGR00833 1199187012187 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1199187012188 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187012189 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1199187012190 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187012191 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1199187012192 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1199187012193 catalytic residue [active] 1199187012194 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1199187012195 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1199187012196 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1199187012197 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1199187012198 active site 1199187012199 NTP binding site [chemical binding]; other site 1199187012200 metal binding triad [ion binding]; metal-binding site 1199187012201 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1199187012202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1199187012203 Zn2+ binding site [ion binding]; other site 1199187012204 Mg2+ binding site [ion binding]; other site 1199187012205 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1199187012206 Flagellar FliJ protein; Region: FliJ; pfam02050 1199187012207 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1199187012208 active site 1199187012209 Ap6A binding site [chemical binding]; other site 1199187012210 nudix motif; other site 1199187012211 metal binding site [ion binding]; metal-binding site 1199187012212 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1199187012213 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1199187012214 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1199187012215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1199187012216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1199187012217 DNA binding residues [nucleotide binding] 1199187012218 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1199187012219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1199187012220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1199187012221 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1199187012222 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1199187012223 catalytic residues [active] 1199187012224 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1199187012225 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1199187012226 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1199187012227 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1199187012228 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1199187012229 active site 1199187012230 metal binding site [ion binding]; metal-binding site 1199187012231 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1199187012232 ParB-like nuclease domain; Region: ParBc; pfam02195 1199187012233 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1199187012234 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1199187012235 P-loop; other site 1199187012236 Magnesium ion binding site [ion binding]; other site 1199187012237 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1199187012238 Magnesium ion binding site [ion binding]; other site 1199187012239 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1199187012240 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1199187012241 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1199187012242 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1199187012243 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1199187012244 G-X-X-G motif; other site 1199187012245 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1199187012246 RxxxH motif; other site 1199187012247 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1199187012248 hypothetical protein; Validated; Region: PRK00041 1199187012249 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1199187012250 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399